EP2285818A4 - BELOXEPINE, ITS ENANTIOMERS AND ANALOGUE FOR PAIN TREATMENT - Google Patents
BELOXEPINE, ITS ENANTIOMERS AND ANALOGUE FOR PAIN TREATMENTInfo
- Publication number
- EP2285818A4 EP2285818A4 EP09712730A EP09712730A EP2285818A4 EP 2285818 A4 EP2285818 A4 EP 2285818A4 EP 09712730 A EP09712730 A EP 09712730A EP 09712730 A EP09712730 A EP 09712730A EP 2285818 A4 EP2285818 A4 EP 2285818A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- beloxepin
- enantiomers
- analogs
- pain
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Pregnancy & Childbirth (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2991608P | 2008-02-19 | 2008-02-19 | |
US2991308P | 2008-02-19 | 2008-02-19 | |
US2991508P | 2008-02-19 | 2008-02-19 | |
US5092108P | 2008-05-06 | 2008-05-06 | |
PCT/US2009/034461 WO2009105507A2 (en) | 2008-02-19 | 2009-02-19 | Beloxepin, its enantiomers, and analogs thereof for the treatment of pain |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2285818A2 EP2285818A2 (en) | 2011-02-23 |
EP2285818A4 true EP2285818A4 (en) | 2011-08-17 |
Family
ID=40986169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP09712730A Withdrawn EP2285818A4 (en) | 2008-02-19 | 2009-02-19 | BELOXEPINE, ITS ENANTIOMERS AND ANALOGUE FOR PAIN TREATMENT |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP2285818A4 (pt) |
JP (1) | JP2011512414A (pt) |
KR (1) | KR20100137473A (pt) |
CN (1) | CN102007139A (pt) |
AU (1) | AU2009215541A1 (pt) |
BR (1) | BRPI0908098A2 (pt) |
CA (1) | CA2715192A1 (pt) |
IL (1) | IL207668A0 (pt) |
MX (1) | MX2010009110A (pt) |
NZ (2) | NZ587896A (pt) |
WO (1) | WO2009105507A2 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090233959A1 (en) | 2008-02-19 | 2009-09-17 | Adolor Corporation | Beloxepin and analogs for the treatment of pain |
EP3261640B1 (en) | 2015-02-25 | 2022-04-06 | The Regents of The University of California | 5ht agonists for treating epilepsy disorders |
CN106243096B (zh) * | 2016-07-29 | 2019-11-29 | 上海璃道医药科技有限公司 | 三环类药物的新用途 |
US10966938B2 (en) | 2019-01-04 | 2021-04-06 | Jonand4, Llc | Composition and method for preventing or treating hangover symptoms |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE62754B1 (en) | 1988-08-26 | 1995-02-22 | Akzo Nv | Tetracyclic antidepressants |
US5663178A (en) | 1995-02-06 | 1997-09-02 | Eli Lilly And Company | Tetrahydro-beta carbolines |
TW440563B (en) * | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
US5952331A (en) | 1996-05-23 | 1999-09-14 | Syntex (Usa) Inc. | Aryl pyrimidine derivatives |
GB0004003D0 (en) * | 2000-02-22 | 2000-04-12 | Knoll Ag | Therapeutic agents |
GB0019950D0 (en) | 2000-08-12 | 2000-09-27 | Smithkline Beecham Plc | Compounds |
EA200500783A1 (ru) * | 2002-12-11 | 2005-12-29 | ФАРМАЦИЯ ЭНД АПДЖОН КОМПАНИ ЭлЭлСи | Комбинация для лечения синдрома дефицита внимания с гиперактивностью |
BRPI0415683A (pt) * | 2003-11-03 | 2006-12-19 | Warner Lambert Co | inibidores da reabsorção de norepinefrina para o tratamento de distúrbios do sistema nervoso central |
CA2588595A1 (en) * | 2004-12-13 | 2006-06-22 | Arena Pharmaceuticals, Inc. | N-biaryl and n-arylheteroaryl piperazine derivatives as modulators of the 5ht2c receptor useful for the treatment of disorders related thereto |
US7915249B2 (en) * | 2005-01-27 | 2011-03-29 | Janssen Pharmaceutical Nv | Heterocyclic tetracyclic tetrahydrofuran derivatives as 5HT2 inhibitors in the treatment of CNS disorders |
WO2006105117A2 (en) * | 2005-03-28 | 2006-10-05 | Dynogen Pharmaceuticals, Inc. | Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors |
CN101277941A (zh) * | 2005-09-29 | 2008-10-01 | 惠氏公司 | 用于治疗由单胺再摄取改善的病状的苯并噻二唑基苯基烷基胺衍生物 |
EP2015765A4 (en) * | 2006-03-28 | 2011-11-23 | Neopro Labs Llc | METHODS AND COMPOSITIONS FOR TREATING CONDITIONS |
GB0608655D0 (en) * | 2006-05-03 | 2006-06-14 | Merck Sharp & Dohme | Therapeutic Treatment |
US20070281924A1 (en) * | 2006-05-31 | 2007-12-06 | Gaeta Federico C | MIF inhibitors for treating neuropathic pain and associated syndromes |
-
2009
- 2009-02-19 KR KR1020107021010A patent/KR20100137473A/ko not_active Application Discontinuation
- 2009-02-19 CA CA2715192A patent/CA2715192A1/en not_active Abandoned
- 2009-02-19 NZ NZ587896A patent/NZ587896A/en not_active IP Right Cessation
- 2009-02-19 WO PCT/US2009/034461 patent/WO2009105507A2/en active Application Filing
- 2009-02-19 MX MX2010009110A patent/MX2010009110A/es not_active Application Discontinuation
- 2009-02-19 CN CN2009801138213A patent/CN102007139A/zh active Pending
- 2009-02-19 EP EP09712730A patent/EP2285818A4/en not_active Withdrawn
- 2009-02-19 BR BRPI0908098-8A patent/BRPI0908098A2/pt not_active IP Right Cessation
- 2009-02-19 AU AU2009215541A patent/AU2009215541A1/en not_active Abandoned
- 2009-02-19 NZ NZ594937A patent/NZ594937A/xx not_active Application Discontinuation
- 2009-02-19 JP JP2010547737A patent/JP2011512414A/ja not_active Withdrawn
-
2010
- 2010-08-18 IL IL207668A patent/IL207668A0/en unknown
Non-Patent Citations (1)
Title |
---|
RUIGT G S F ET AL: "Antidepressant characteristics of Org 3770, Org 4428 and Org 9768 on rat sleep", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, vol. 183, no. 4, 4 July 1990 (1990-07-04), pages 1467 - 1468, XP023838768, ISSN: 0014-2999, [retrieved on 19900704], DOI: 10.1016/0014-2999(90)94611-Z * |
Also Published As
Publication number | Publication date |
---|---|
MX2010009110A (es) | 2010-11-30 |
JP2011512414A (ja) | 2011-04-21 |
WO2009105507A3 (en) | 2010-01-14 |
NZ594937A (en) | 2013-03-28 |
EP2285818A2 (en) | 2011-02-23 |
AU2009215541A1 (en) | 2009-08-27 |
KR20100137473A (ko) | 2010-12-30 |
WO2009105507A2 (en) | 2009-08-27 |
BRPI0908098A2 (pt) | 2015-08-18 |
IL207668A0 (en) | 2010-12-30 |
CA2715192A1 (en) | 2009-08-27 |
NZ587896A (en) | 2011-09-30 |
CN102007139A (zh) | 2011-04-06 |
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Legal Events
Date | Code | Title | Description |
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Extension state: AL BA RS |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20110715 |
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Ipc: C07H 17/08 20060101AFI20110711BHEP |
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