EP2285217A4 - Composés utilisables pour l'amélioration de l'apprentissage et de la mémoire - Google Patents

Composés utilisables pour l'amélioration de l'apprentissage et de la mémoire

Info

Publication number
EP2285217A4
EP2285217A4 EP09747284A EP09747284A EP2285217A4 EP 2285217 A4 EP2285217 A4 EP 2285217A4 EP 09747284 A EP09747284 A EP 09747284A EP 09747284 A EP09747284 A EP 09747284A EP 2285217 A4 EP2285217 A4 EP 2285217A4
Authority
EP
European Patent Office
Prior art keywords
compounds
memory
improving learning
learning
improving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09747284A
Other languages
German (de)
English (en)
Other versions
EP2285217A1 (fr
Inventor
Karoly Nikolich
Laszlo Nadasdi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amnestix Inc
Original Assignee
Amnestix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amnestix Inc filed Critical Amnestix Inc
Publication of EP2285217A1 publication Critical patent/EP2285217A1/fr
Publication of EP2285217A4 publication Critical patent/EP2285217A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP09747284A 2008-05-12 2009-05-11 Composés utilisables pour l'amélioration de l'apprentissage et de la mémoire Withdrawn EP2285217A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5260008P 2008-05-12 2008-05-12
PCT/US2009/043467 WO2009140200A1 (fr) 2008-05-12 2009-05-11 Composés utilisables pour l'amélioration de l'apprentissage et de la mémoire

Publications (2)

Publication Number Publication Date
EP2285217A1 EP2285217A1 (fr) 2011-02-23
EP2285217A4 true EP2285217A4 (fr) 2011-06-08

Family

ID=41319017

Family Applications (2)

Application Number Title Priority Date Filing Date
EP09747284A Withdrawn EP2285217A4 (fr) 2008-05-12 2009-05-11 Composés utilisables pour l'amélioration de l'apprentissage et de la mémoire
EP09763136A Withdrawn EP2296472A4 (fr) 2008-05-12 2009-05-11 Composés pour inhiber les rho kinases et pour améliorer l'apprentissage et la mémoire

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP09763136A Withdrawn EP2296472A4 (fr) 2008-05-12 2009-05-11 Composés pour inhiber les rho kinases et pour améliorer l'apprentissage et la mémoire

Country Status (10)

Country Link
US (3) US20110294789A1 (fr)
EP (2) EP2285217A4 (fr)
JP (2) JP2011519972A (fr)
KR (2) KR20110011669A (fr)
CN (2) CN102088853A (fr)
AU (2) AU2009246568A1 (fr)
BR (2) BRPI0912337A2 (fr)
CA (2) CA2725416A1 (fr)
MX (2) MX2010012103A (fr)
WO (2) WO2009140200A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0912337A2 (pt) * 2008-05-12 2019-09-24 Amnestix Inc composto método para melhorar memória em paciente, e, método para tratar condições
US8703736B2 (en) * 2011-04-04 2014-04-22 The Translational Genomics Research Institute Therapeutic target for pancreatic cancer cells
AU2013207972B2 (en) * 2012-01-10 2017-06-15 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
US9278950B2 (en) 2013-01-14 2016-03-08 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
AR094664A1 (es) 2013-01-15 2015-08-19 Incyte Corp Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim
BR112015021524A2 (pt) * 2013-03-04 2017-07-18 Advanced Medical Res Institute Of Canada derivados de sulfonil quinolina e usos dos mesmos
US9556197B2 (en) 2013-08-23 2017-01-31 Incyte Corporation Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
US9617214B2 (en) 2013-11-08 2017-04-11 The Translational Genomics Research Institute Compounds for cognitive enhancement and methods of use thereof
CN105085478B (zh) * 2014-04-28 2019-04-12 南京明德新药研发股份有限公司 异喹啉磺胺衍生物及其药物组合物和制药用途
WO2016010897A1 (fr) 2014-07-14 2016-01-21 Incyte Corporation Composés carboxamide hétéroaromatiques bicycliques utiles en tant qu'inhibiteurs de kinases pim
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016196244A1 (fr) 2015-05-29 2016-12-08 Incyte Corporation Composés de pyridineamine utiles en tant qu'inhibiteurs de kinase pim
AR105967A1 (es) 2015-09-09 2017-11-29 Incyte Corp Sales de un inhibidor de pim quinasa
US9920032B2 (en) 2015-10-02 2018-03-20 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
NZ742476A (en) 2015-12-17 2022-09-30 Merck Patent Gmbh Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders
RU2758686C2 (ru) 2016-08-08 2021-11-01 Мерк Патент Гмбх Антагонисты tlr7/8 и их применение
WO2019015608A1 (fr) * 2017-07-19 2019-01-24 南京明德新药研发股份有限公司 Dérivé d'isoquinoléinylsulfonyle et son utilisation
WO2019113487A1 (fr) 2017-12-08 2019-06-13 Incyte Corporation Polythérapie à faible dose pour le traitement de néoplasmes myéloprolifératifs
EP3868408A4 (fr) 2018-10-15 2022-07-06 National University Corporation Tokai National Higher Education and Research System Antipsychotique et utilisation associée
JP2023509970A (ja) 2020-01-09 2023-03-10 ウールジー・ファーマシューティカルズ・インコーポレイテッド 皮質性認知症に関連する徘徊を治療する方法
CA3169944A1 (fr) * 2020-03-25 2021-09-30 Thomas Macallister Methodes d'utilisation d'inhibiteurs de la kinase associee a rho pour traiter la demence fronto-temporale
JP2023518707A (ja) 2020-03-25 2023-05-08 ウールジー・ファーマシューティカルズ・インコーポレイテッド タンパク質症に関連する徘徊を治療する方法
CN115996728A (zh) * 2020-04-23 2023-04-21 乌尔塞制药公司 利用Rho激酶抑制剂治疗阿尔茨海默病的方法
MX2022015800A (es) * 2020-06-15 2023-01-24 Woolsey Pharmaceuticals Inc Metodos de uso de inhibidores de la quinasa rho para tratar demencia vascular.
MX2022016336A (es) * 2020-06-25 2023-01-24 Woolsey Pharmaceuticals Inc Metodos de tratamiento de trastornos del neurodesarrollo.
EP4181925A1 (fr) * 2020-07-14 2023-05-24 Woolsey Pharmaceuticals, Inc. Méthodes de traitement de protéinopathies
US11311553B1 (en) 2020-10-22 2022-04-26 Woolsey Pharmaceuticals, Inc. Methods of treating 4-repeat tauopathies

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004106325A1 (fr) * 2003-05-29 2004-12-09 Schering Aktiengesellschaft Promedicaments de 1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine
WO2008019395A2 (fr) * 2006-08-10 2008-02-14 Translational Genomics Research Institute Composés pour améliorer l'apprentissage et la mémoire

Family Cites Families (12)

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US4456757A (en) * 1981-03-20 1984-06-26 Asahi Kasei Kogyo Kabushiki Kaisha Isoquinolinesulfonyl derivatives and process for the preparation thereof
US4678783B1 (en) * 1983-11-04 1995-04-04 Asahi Chemical Ind Substituted isoquinolinesulfonyl compounds
CN100389828C (zh) * 1996-08-12 2008-05-28 三菱制药株式会社 含Rho激酶抑制剂的药物制剂
AU4990599A (en) * 1998-07-14 2000-02-07 Brigham And Women's Hospital Upregulation of type iii endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization
US7115607B2 (en) * 2001-07-25 2006-10-03 Amgen Inc. Substituted piperazinyl amides and methods of use
AU2003228348A1 (en) * 2002-03-20 2003-10-08 John T. Fassett Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors
ES2361924T3 (es) * 2002-12-20 2011-06-24 X-Ceptor Therapeutics, Inc. Derivados de isoquinolinona y su uso como agentes terapéuticos.
US20080096238A1 (en) * 2004-03-30 2008-04-24 Alcon, Inc. High throughput assay for human rho kinase activity with enhanced signal-to-noise ratio
WO2005117896A1 (fr) * 2004-06-03 2005-12-15 Schering Aktiengesellschaft Formulations contenant du fasudil, une matrice et une enveloppe
BRPI0614974A2 (pt) * 2005-08-30 2010-12-14 Asahi Kasei Pharma Corp composto, medicamento, inibidor da fosforilaÇço da cadeia leve regulatària da miosina, inibidor da via rho/rho quinase, e, mÉtodo para tratamento terapÊutico e/ou profilÁtico de glaucoma
KR20080063806A (ko) * 2005-10-06 2008-07-07 쉐링 코포레이션 단백질 키나제 억제제로서의 피라졸로피리미딘
BRPI0912337A2 (pt) * 2008-05-12 2019-09-24 Amnestix Inc composto método para melhorar memória em paciente, e, método para tratar condições

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004106325A1 (fr) * 2003-05-29 2004-12-09 Schering Aktiengesellschaft Promedicaments de 1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine
WO2008019395A2 (fr) * 2006-08-10 2008-02-14 Translational Genomics Research Institute Composés pour améliorer l'apprentissage et la mémoire

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2009140200A1 *

Also Published As

Publication number Publication date
KR20110011669A (ko) 2011-02-08
US20100160297A1 (en) 2010-06-24
MX2010012103A (es) 2011-04-04
US20110237600A1 (en) 2011-09-29
EP2296472A4 (fr) 2011-06-08
JP2011519972A (ja) 2011-07-14
CN102316737A (zh) 2012-01-11
WO2009151845A1 (fr) 2009-12-17
CN102088853A (zh) 2011-06-08
MX2010012104A (es) 2011-04-05
AU2009257926A1 (en) 2009-12-17
JP2011519973A (ja) 2011-07-14
WO2009140200A1 (fr) 2009-11-19
WO2009151845A9 (fr) 2010-01-28
EP2285217A1 (fr) 2011-02-23
KR20110014183A (ko) 2011-02-10
EP2296472A1 (fr) 2011-03-23
US20110294789A1 (en) 2011-12-01
AU2009246568A1 (en) 2009-11-19
CA2723472A1 (fr) 2009-12-17
BRPI0912386A2 (pt) 2016-07-26
BRPI0912337A2 (pt) 2019-09-24
CA2725416A1 (fr) 2009-11-19

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