EP2236199A2 - Processus et installation pour le dosage et mélange automatique et stérile d'infusions - Google Patents

Processus et installation pour le dosage et mélange automatique et stérile d'infusions Download PDF

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Publication number
EP2236199A2
EP2236199A2 EP10158580A EP10158580A EP2236199A2 EP 2236199 A2 EP2236199 A2 EP 2236199A2 EP 10158580 A EP10158580 A EP 10158580A EP 10158580 A EP10158580 A EP 10158580A EP 2236199 A2 EP2236199 A2 EP 2236199A2
Authority
EP
European Patent Office
Prior art keywords
mixing
syringe
robot
gripper
mixing chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP10158580A
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German (de)
English (en)
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EP2236199B1 (fr
EP2236199A3 (fr
Inventor
Ludger Fischer
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Individual
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Individual
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Publication of EP2236199A3 publication Critical patent/EP2236199A3/fr
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/85—Mixing plants with mixing receptacles or mixing tools that can be indexed into different working positions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/002—Compounding apparatus specially for enteral or parenteral nutritive solutions

Definitions

  • the present invention relates to a method as well as a device for the automated sterile dosing and mixing of infusions according to individually prepared recipes. So far, the attending physician defined by his diagnosis, a certain composition or mixture and dosage of an infusion for a particular patient. After this individual recipe, the infusion is then prepared under sterile conditions. Until now, this work had to be done by hand, because no automation seemed possible, because it is about the provision of individual and thus constantly changing recipes. In principle, errors due to human error are possible, and the traceability of the infusions produced in this way is not completely guaranteed. Due to the manual preparation of the infusions, because of the applicable guidelines and regulations, many very expensive active ingredients are disposed of, for example because a bottle that has once been opened may not necessarily be reused. In addition, there is a risk for the staff, because in case of puncture injuries, contamination with antibodies can not be ruled out.
  • doses are determined by the doctors, which unfortunately do not allow the complete exhaustion of drug units. For example, if a drug or drug in a pack size of 150mg offered and prescribed by the doctor in a dosage of 330mg, the third pack only started and 120mg are thrown away or disposed of. Further use is only possible under very specific circumstances. However, if one could work completely sterile and reliably avoid backmixing, then broken portions of the active ingredient could continue to be used. Achieving this is one of the objects of the present automated method and apparatus for its implementation.
  • Dosing and mixing in the clinic would facilitate a patient-oriented, individualized dosage.
  • the communication steps for the delivery of infusions are to be reduced and the manufacture in the clinic should increase the safety and extend the shelf life of the infusions. It should also be ensured traceability of all handling steps.
  • the dosages should be achieved by accurate weighing as a method of measurement, which can be checked again by weighing after completion of the dosage.
  • a device for the automated dosing and mixing of active substances for the preparation of patient-suitable infusions for installation in a class B or C clean room, comprising a computer with robot control software, a storage space for educts with a shelf tablet, a clean room class A mixing room with constant ventilation, and therein a shelf tray and a mixing vessel scale and a disposal container, and a storage space for the finished products, with containers carried by a carousel, the mixing room enclosing a robot with a gripper and with a suction syringe which gripper computer controlled certain vials from the storage room in the mixing room are holbar, as well as which suction syringe computer controlled educts from the parked in the mixing chamber vials and ejected into a mixing vessel on the mixing vessel scale in the mixing chamber, and with which suction syringe except em mixtures from the mixing vessel and sucked into the receptacle for the finished product can be
  • FIG. 1 the entire facility is shown. It forms a complete workplace for mixing and providing application-capable infusions.
  • this facility includes a storage room 1 for reactants 2 to be mixed, that is to say for the pure active ingredients or medicaments, as they are to be administered to the patient in certain concentrations and dosages by means of infusions.
  • the vials 3 or also called vials, which contain the educts 2, are in a shelf tray 4 with, for example, as shown here 7 x 3 holes for placing the educt vial 3.
  • each vial 3 at a well-defined location in the shelf 4 stored.
  • the vials 3 are first sorted by hand in the shelf trays 4 on the table 9 left of the device and afterwards the shelf trays 4 are put into the storage room 1.
  • a scanner 12 on which the individual educt vial 3 can be identified by their barcodes. With a cooling circuit, this cools the bottom of the storage room 1 as well as the adjoining mixing chamber 10, so that it can be maintained at a temperature of about 6 ° ⁇ 2 ° C.
  • the educt vial 3 are within the shelf tray 4 on this cooled floor, so that the reactants 2 are cooled.
  • a mixing chamber 10 connects. This is designed as a class A cleanroom and is therefore constantly flowed through by filtered air.
  • the mixing chamber 10 includes a robot that functions similarly to a bridge crane.
  • the side walls of the mixing chamber are 10 as you can see provided with recesses 25 through which air always flows through from the mixing chamber 1, but never in the opposite direction.
  • a gripper 15 and a syringe 16 reciprocates, and the whole rail 11 also runs along the side rails 14 in the direction of the viewer backwards and forwards.
  • the side rails 14 are partially visible on the outer side walls of the storage room 1 and the discharge space 13.
  • the gripper 15 and the syringe 16 can move back and forth on the rail 11 1, and the entire rail 11 can move forwards and backwards, and furthermore the gripper 15 and the syringe 16 can be attached to the rail 11 by means of a mechanical, electric, pneumatic or hydraulic drive up and drive down.
  • a shelf tray 4 which is empty at the moment.
  • a mixing vessel scale 17 is arranged, and disposed between the shelf tray 4 and the mixing vessel 17, slightly offset to the rear, one recognizes a disposal hole 18 in the bottom of the mixing chamber 10. Through this disposal hole 18 spent vials can be disposed of and then fall into a the disposal hole 18 attached waste container 26.
  • a syringe magazine 22 is housed at the right side wall of the mixing chamber 10.
  • a carousel 19 is arranged, with a shaft 23 as a rotation axis and attached turntables 31,32, which are provided at its edge with incisions so that infusion bottles 20 between these turntables 31,32 are suspended.
  • This carousel 19 is rotatable by motor and the motor is controlled by the computer 6, as well as the entire robot with its gripper 15 and its syringe 16 is controllable in its movements.
  • a scanner 21 Inside the dispensing compartment 13 there is also a scanner 21 which can read the bar codes on the infusion bags 20 as they pass it.
  • FIG. 2 is the storage room 1 seen from the front.
  • Cross rail 11 which is mounted laterally on the side rail 14 and can drive along the same as a whole to the front and rear, that is perpendicular to the drawing sheet level.
  • the electric motor 30 is on the floor of the storage room 1 are three shelf trays 4 side by side.
  • the bottom of the storage room 1 is cooled by means of the cooling circuit already described, so that the active ingredients in the vial 3 are durable.
  • the shelf tray on the right contains mixing vessels 24.
  • FIG. 3 is the mixing chamber 10 seen from the front.
  • the robot gripper 15 can take the vial in the underlying shelf trays 4 or they can place targeted in these shelf trays 4.
  • the robot syringe 16 can be seen, which can enter through the septums in the individual vials in the shelf trays 4.
  • Both elements that is, the robot gripper 15 as well as the robot syringe 16 can move together along the rail 11 back and forth and drive together with the rail 11 forward or backward.
  • the gripper 15 and the syringe 16 can move up and down the rail 11, so they can move in all three spatial directions.
  • the syringe 16 is connected to the robot so that it can be lowered to the bottom of a vial 3 with a certain adjustable contact pressure is.
  • This can be solved so that the electric motor moves the syringe by means of a threaded spindle downwards and then suddenly after impingement of the syringe tip on the bottom of the bottle, the torque on the electric motor of the linear drive increases sharply, which correlates with the absorption current of the electric motor. On the recording current, which can be interrupted when reaching a certain size, therefore, can adjust the torque and thus the contact pressure.
  • Another solution may be that the syringe 16 hangs on the robot via a compression spring.
  • an expansion strip may be attached, which leads to a stationary part above the robot and is fixed there.
  • the syringe is then driven by motor, electric, pneumatic or hydraulic down.
  • motor, electric, pneumatic or hydraulic down When its tip hits the bottom of a vial, further downward movement of the robot is accomplished by compressing the compression spring and at the same time the stretchstrip is stretched. Depending on the strain, it gives off an altered electrical signal, which then gives a measure of the pressure applied.
  • FIG. 4 one sees the carousel 19 for a total of 10 infusion bottles 20.
  • the shaft 23 of the carousel 19, which is mounted above and below in the output space is sealed by Simmeringen and stored in closed ball bearings. It can be easily removed.
  • This carousel 19, which includes two externally provided with cuts turntables 31,32 is hung after the placement of these 10 infusion bottles 20 in the interior of the output space 13, where it is rotatable by motor.
  • the dispensing space 13 is equipped with a scanner 21 which can read the patient-specific barcodes on the infusion bottles 20 and the locations of the individual infusion bottles 20 in the carousel 19 are numbered.
  • the carousel 19 is rotated past the scanner 21 with the infusion bottles 20 and can be stopped in any desired position, with a ⁇ 1 mm accuracy over the X and Y coordinates, so that a well-defined infusion bottle 20 will ultimately be pierced by the syringe because the system includes a position detection.
  • FIG. 5 is a shelf tray 4 shown in a section. These shelf trays preferably consist of a plurality of spaced apart stacked Plexiglas plates.
  • the adjustment holes 27 are of stepped diameters so that, as shown, vials 3 of different diameters can be received without wobble.
  • These are active substance vials 3 from 10m1 to 25ml content for highly active substances such as Avastin or Herceptin from Roche or similar substances from other companies.
  • the excipients are present in larger vials 3 of 50ml content.
  • the FIG. 5 is a shelf tray 4 shown in a section. These shelf trays preferably consist of a plurality of spaced apart stacked Plexiglas plates.
  • the adjustment holes 27 are of stepped diameters so that, as shown, vials 3 of different diameters can be received without wobble.
  • These are active substance vials 3 from 10m1 to 25ml content for highly active substances such as Avastin or Herceptin from Roche or similar substances from other companies.
  • FIG. 6 shows on the left a shelf tray 4 for drug vial 3 seen from above, each with 3 x 7 holes 27 and right next to a shelf tray for excipients vial with 2 x 5 larger holes 28 for receiving larger vials 3.
  • Die FIG. 7 finally shows a shelf tray 4 for the mixing chamber 10, which has 3 x 5 holes 27 for stock solutions, ie for drug vial 3, and a larger hole 28 for a carrier solution bottle (NaCl).
  • the entire facility as in FIG. 1 is shown in a class B or C clean room, while the mixing vessel space 3 itself forms a class A clean room.
  • the mixing vessel space 3 must have a supply and exhaust air connection, which are connected to an external fan with Hepafilter so that it is constantly flowed through by a defined flow of air.
  • All three rooms 1, 10 and 13 are made of smooth flat surfaces, making them easy to clean, and they can be closed with doors or covers.
  • the doors are electronically interrogated, whether they are open or closed, but must not be locked and lockable.
  • the entire device is operated and controlled via an associated external PC 6 with monitor 8 and keyboard 7 or optionally via a touch screen and the monitor 8 of the device displays its status, for example, which recipe is being mixed.
  • the operator typically a medical-technical assistant or assistant MTA prepares the placement of the storage room 1, which happens on the preparation table 9.
  • the prescriptions come in the form of electronic data, which are read into the computer.
  • the computer calculates afterwards, which Edukte are necessary, and afterwards, like the shelf tray with which educt vial 3 is to be equipped wisely.
  • the vials 3 are provided, prior to insertion into the shelf tray 4, with a bar code which, for example, is glued to the bottom of the vial 3 at the bottom.
  • Some products already have a barcode attached by the manufacturer. In the goods receiving the own barcodes are retrofitted with such products. The most space in this case is the bottom of the bottle.
  • the barcodes are attached to the cylindrical part of the vial. Then the bar code scanner must be sideways and the bottle gripper must make a rotary motion to interrogate the entire cylinder cylinder.
  • the vials are simply held over the upwardly facing scanner, similar to the system used by a purse, and are uniquely identified. This marking on the bottom of the bottle is the superior system as it is technically easier to implement and ensures traceability. It is only more elaborate in the receipt of goods.
  • the software of the computer indicates the MTA when loading the input products by a position specification, where exactly the vial 3 in the shelf tray 4 must be used.
  • the vials 3 are later scanned by the mixing machine with the barcode scanner before use, so that misuse by the MTA is detected immediately prior to mixing. This individualized detection of each vial 3 is the first time a clear traceability is given. This ultimately makes it possible to implement a traceable information chain from the goods receipt to the patient, and this applies to each individual vial 3.
  • the shelf trays 4 are coded with lugs and guide pins and therefore can not be arbitrarily, but only in the correct direction and position in the storage room 1 are inserted.
  • the sealing seals of the vials 3 are removed. It refers to Metal caps that are removed so that afterwards only the septums close the vials 3.
  • a shelf tray 4 When a shelf tray 4 is fully stocked by the MTA, it is inserted into the storage room 1 and hence the starting materials are cooled by the bottom of the storage room 1 and kept at a temperature of about 6 ° ⁇ 2 ° C.
  • the dosing and mixing process starts for a recipe read into the computer and is then carried out completely automatically.
  • the gripper 15 first gets an auxiliary bottle from the storage room 1 and places it after passing the scanner 12 and according to their identification in the larger hole 28 in the shelf tray 4 in the mixing chamber 1. Thereafter, the gripper 15 moves back into the storage room 1 and over the shelf tray 4 and knows in which position (xy coordinate) the required drug vial 3 with the desired starting material 2 inserted.
  • the gripper 15 grips this vial 3 and holds it in front of the scanner 12 in the storage room 1. It rotates it around the axis if the barcode is placed laterally so that it can be safely read by the scanner 12, or if the barcode is on the bottom of the bottle The gripper 15 holds the bottle 3 over the scanner 12. After correctly identifying the bottle 3, the gripper 15 brings it into the mixing chamber 10 and places it there at a position calculated in the shelf tray 4 by the computer 6. Afterwards we fetched the second, third, fourth, etc. vials 3 in the same way from the storage room 1 and, after proper identification, deposited them in the mixing chamber 10. The robot also fetches a mixing vessel 24 in the storage room 1 and places it on the mixing balance 17. Once the necessary vials 3 with their educts 2 and the excipient bottle and the mixing vessel 24 are placed in the mixing chamber 10, the dosage and mixing can begin.
  • the robot gets a new syringe 16 from the syringe magazine 22 in the mixing chamber 10. Then he leads the syringe 16 into the excipient bottle.
  • the tip of the syringe 16 pierces the septum and descends to the bottom of the bottle until the syringe tip applies a certain adjustable force to the bottom of the bottle.
  • the piston in the syringe is controlled by the computer computer controlled a precisely defined measure reduced and the syringe 16 therefore sucks excipient of a very specific volume from the bottle.
  • the syringe 16 is then moved over the mixing vessel 24 on the balance 17 and the piston is moved forward to the stop in the syringe 16, which thereby emits its contents in the mixing vessel 24. In this case, the weight increase of the mixing vessel 24 is measured and recorded.
  • the robot drives the syringe 16 into the first drug vial 3.
  • the tip of the syringe 16 pierces the septum and is driven down to the bottom of the bottle until the syringe tip applies a certain adjustable force to the bottom of the bottle.
  • the piston in the syringe 16 is controlled by the computer controlled a precisely defined Mass reduced and the syringe 16 therefore sucks active substance of a very specific volume from the vial 3.
  • the syringe is then moved over the mixing vessel 24 and the piston is to the front to stop drove in the syringe, which thereby emits their contents in the mixing vessel 24. This process is repeated until the desired amount of active ingredient in the mixing vessel 24 is. Then it is repeated with the next active substance, etc., until all the active ingredients in the desired dose are in the mixing vessel 24 and mix there.
  • the infusion bottle 20 previously rotated to the exceptional position is pierced with the syringe tip, and the plunger in the syringe 16 is moved forward, so that the syringe contents are dispensed into the infusion bottle 20.
  • the robot with the syringe 16 moves back into the mixing chamber 10 and drops it over the disposal hole 18 into the disposal container 26.
  • the gripper 15 then collects the empty active substance bottles 3 together and leaves them fall over the disposal hole 18.
  • the excipient bottle and the mixing vessel 24 are disposed of.
  • the shelf tray 3 is re-stocked in the storage room 1, whereby opened drug vials 3 can be used on, as well as a broken auxiliary bottle also.
  • a new mixing vessel 24 is placed on the mixing balance 17 each time.
  • a new dosing and mixing passage begins and the next infusion bottle 20 is filled until all the infusion bottles 20 of the carousel 19 are filled.
  • a signal is emitted to allow the MTA to recognize that it can now remove the infusion bottles 20 from the dispensing compartment 13 and populate them with new empty infusion bottles 20.
  • Each infusion bottle 20 contains the infusion mixture defined according to its barcode, which is tailored to a very individual patient. The entire dosage and mixture is documented by the recorded in the computer 6 steps of the mixing process and detectable at any time.
  • the dosage and mixture is safer, faster and more economical. In addition, any danger to personnel caused by stabs and contamination is excluded.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP10158580A 2009-04-01 2010-03-31 Processus et installation pour le dosage et mélange automatique et stérile d'infusions Not-in-force EP2236199B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH00537/09A CH700740A2 (de) 2009-04-01 2009-04-01 Verfahren und Einrichtung zum automatisierten sterilen Dosieren und Mischen von Infusionen.

Publications (3)

Publication Number Publication Date
EP2236199A2 true EP2236199A2 (fr) 2010-10-06
EP2236199A3 EP2236199A3 (fr) 2010-10-20
EP2236199B1 EP2236199B1 (fr) 2012-05-30

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EP10158580A Not-in-force EP2236199B1 (fr) 2009-04-01 2010-03-31 Processus et installation pour le dosage et mélange automatique et stérile d'infusions

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EP (1) EP2236199B1 (fr)
CH (1) CH700740A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104602665A (zh) * 2012-10-25 2015-05-06 株式会社汤山制作所 混注装置
WO2019217864A1 (fr) * 2018-05-11 2019-11-14 Bristol-Myers Squibb Company Dispositif d'administration de médicament combinatoire
WO2021058616A1 (fr) * 2019-09-27 2021-04-01 Bausch + Ströbel Maschinenfabrik Ilshofen GmbH + Co. KG Dispositif de production, notamment pour l'industrie pharmaceutique
CN115487716A (zh) * 2022-11-22 2022-12-20 莱州市文昌路畜牧兽医站 一种兽医用配药装置

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017005835B4 (de) * 2017-06-20 2020-04-02 Diehl Metering Gmbh Vorrichtung zur mobilen Bestimmung einer Eigenschaft einer flüssigen, festen oder gasförmigen Probe

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5431201A (en) * 1993-12-03 1995-07-11 Technology 2000 Incororated Robotic admixture system
DK1363736T3 (da) * 2000-12-18 2011-06-27 Protedyne Corp Ekstrudering af gelmateriale til gelelektroforese
EP1291658A1 (fr) * 2001-09-07 2003-03-12 The Automation Partnership (Cambridge) Limited Tête pipettage pour robot
US7783383B2 (en) * 2004-12-22 2010-08-24 Intelligent Hospital Systems Ltd. Automated pharmacy admixture system (APAS)
AU2006346753A1 (en) * 2006-07-26 2008-01-31 Health Robotics S.R.L. Machine for the preparation of pharmaceutical products
US20080169044A1 (en) * 2006-10-20 2008-07-17 Forhealth Technologies, Inc. Automated drug preparation apparatus including syringe loading, preparation and filling
FR2932085B1 (fr) * 2008-06-06 2012-08-10 Pharmed Sam Station de travail automatisee pour la preparation securisee d'un produit final a usage medical ou pharmaceutique

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104602665A (zh) * 2012-10-25 2015-05-06 株式会社汤山制作所 混注装置
CN104602665B (zh) * 2012-10-25 2018-09-18 株式会社汤山制作所 混注装置
WO2019217864A1 (fr) * 2018-05-11 2019-11-14 Bristol-Myers Squibb Company Dispositif d'administration de médicament combinatoire
US11497685B2 (en) 2018-05-11 2022-11-15 Bristol-Myers Squibb Company Combinatorial drug delivery device
US11801199B2 (en) 2018-05-11 2023-10-31 Bristol-Myers Squibb Company Combinatorial drug delivery device
EP4344695A3 (fr) * 2018-05-11 2024-06-05 Bristol-Myers Squibb Company Dispositif d'administration de médicament combinatoire
WO2021058616A1 (fr) * 2019-09-27 2021-04-01 Bausch + Ströbel Maschinenfabrik Ilshofen GmbH + Co. KG Dispositif de production, notamment pour l'industrie pharmaceutique
CN113939581A (zh) * 2019-09-27 2022-01-14 鲍施+施特勒贝尔机械伊尔斯霍芬有限两合公司 生产装置、尤其用于制药行业的生产装置
US20220339804A1 (en) * 2019-09-27 2022-10-27 Bausch + Ströbel Maschinenfabrik Ilshofen GmbH + Co. KG Production device, in particular for the pharmaceutical industry
CN115487716A (zh) * 2022-11-22 2022-12-20 莱州市文昌路畜牧兽医站 一种兽医用配药装置
CN115487716B (zh) * 2022-11-22 2023-03-10 莱州市文昌路畜牧兽医站 一种兽医用配药装置

Also Published As

Publication number Publication date
CH700740A2 (de) 2010-10-15
EP2236199B1 (fr) 2012-05-30
EP2236199A3 (fr) 2010-10-20

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