EP2228070A3 - Modulation d'apoptose de cellules de la granulosa - Google Patents

Modulation d'apoptose de cellules de la granulosa Download PDF

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Publication number
EP2228070A3
EP2228070A3 EP20100004342 EP10004342A EP2228070A3 EP 2228070 A3 EP2228070 A3 EP 2228070A3 EP 20100004342 EP20100004342 EP 20100004342 EP 10004342 A EP10004342 A EP 10004342A EP 2228070 A3 EP2228070 A3 EP 2228070A3
Authority
EP
European Patent Office
Prior art keywords
modulation
cell apoptosis
granulosa cell
oocyte
gdf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP20100004342
Other languages
German (de)
English (en)
Other versions
EP2228070B1 (fr
EP2228070A2 (fr
Inventor
Robert Bruce Gilchrist
Jeremy Thompson
Tamer Hussein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adelaide Research and Innovation Pty Ltd
Original Assignee
Adelaide Research and Innovation Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2005903782A external-priority patent/AU2005903782A0/en
Application filed by Adelaide Research and Innovation Pty Ltd filed Critical Adelaide Research and Innovation Pty Ltd
Publication of EP2228070A2 publication Critical patent/EP2228070A2/fr
Publication of EP2228070A3 publication Critical patent/EP2228070A3/fr
Application granted granted Critical
Publication of EP2228070B1 publication Critical patent/EP2228070B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0609—Oocytes, oogonia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0604—Whole embryos; Culture medium therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/19—Growth and differentiation factors [GDF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/04—Coculture with; Conditioned medium produced by germ cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP10004342.1A 2005-07-18 2006-07-18 Modulation d'apoptose de cellules de la granulosa Not-in-force EP2228070B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2005903782A AU2005903782A0 (en) 2005-07-18 Modulation of granulosa cell apoptosis
EP06760864A EP1909820A4 (fr) 2005-07-18 2006-07-18 Modulation de l'apoptose des cellules de la granulosa

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP06760864.6 Division 2006-07-18
EP06760864A Division EP1909820A4 (fr) 2005-07-18 2006-07-18 Modulation de l'apoptose des cellules de la granulosa

Publications (3)

Publication Number Publication Date
EP2228070A2 EP2228070A2 (fr) 2010-09-15
EP2228070A3 true EP2228070A3 (fr) 2010-12-29
EP2228070B1 EP2228070B1 (fr) 2016-09-07

Family

ID=37668339

Family Applications (2)

Application Number Title Priority Date Filing Date
EP06760864A Withdrawn EP1909820A4 (fr) 2005-07-18 2006-07-18 Modulation de l'apoptose des cellules de la granulosa
EP10004342.1A Not-in-force EP2228070B1 (fr) 2005-07-18 2006-07-18 Modulation d'apoptose de cellules de la granulosa

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP06760864A Withdrawn EP1909820A4 (fr) 2005-07-18 2006-07-18 Modulation de l'apoptose des cellules de la granulosa

Country Status (8)

Country Link
US (2) US8530235B2 (fr)
EP (2) EP1909820A4 (fr)
JP (2) JP2009501533A (fr)
KR (1) KR101502110B1 (fr)
CN (1) CN101272804A (fr)
CA (1) CA2615006A1 (fr)
DK (1) DK2228070T3 (fr)
WO (1) WO2007009166A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014018404A1 (fr) * 2012-07-21 2014-01-30 Baylor College Of Medicine Hétérodimères gdf9/bmp15 pour augmenter la fertilité
US20160237402A1 (en) * 2013-10-07 2016-08-18 Northeastern University Methods and Compositions for Ex Vivo Generation of Developmentally Competent Eggs from Germ Line Cells Using Autologous Cell Systems
EP3122366A4 (fr) 2014-03-27 2017-11-15 Jonathan Lee Tilly Procédés de croissance et de maturation de follicules ovariens
WO2018141015A1 (fr) * 2017-02-01 2018-08-09 Newsouth Innovations Pty Limited Facteurs de croissance sécrétés par les gamètes
JP7340866B2 (ja) 2018-05-09 2023-09-08 モナッシュ ユニバーシティ 妊孕性を高めるための薬剤及び方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032222A1 (fr) * 1998-12-01 2000-06-08 Akzo Nobel N.V. Amelioration de la folliculogenese

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994015966A1 (fr) * 1993-01-12 1994-07-21 Johns Hopkins University School Of Medicine Facteur-9 de croissance et de differentiation
US6030617A (en) * 1993-01-12 2000-02-29 The Johns Hopkins University School Of Medicine Use of growth differentiation factor-9 (GDF-9) to inhibit oocyte maturation
WO1999050672A1 (fr) * 1998-04-01 1999-10-07 Baylor College Of Medicine Analyse pour facteur 9 de differenciation de croissance
NZ502796A (en) * 2000-06-15 2003-02-28 Agres Ltd Nucleotide and amino acid sequences of oocyte factors related to GDF-9B or GDF-9
FR2812004B1 (fr) * 2000-07-24 2002-12-27 Ccd Lab Milieux de culture pour fecondation in vitro, ou pour la culture de follicules, cellules germinales males ou embryons
WO2005097978A1 (fr) * 2004-04-06 2005-10-20 Adelaide Research & Innovation Pty Ltd Modulation de la proliferation et de la differenciationdes cellules de la granulosa
CA2589898A1 (fr) * 2004-12-02 2006-06-08 Agresearch Limited Modulation de l'ovulation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032222A1 (fr) * 1998-12-01 2000-06-08 Akzo Nobel N.V. Amelioration de la folliculogenese

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BRAW-TAL R: "The initiation of follicle growth:the oocyte or the somatic cells?", MOLECULAR AND CELLULAR ENDOCRINOLOGY, ELSEVIER IRELAND LTD, IE LNKD- DOI:10.1016/S0303-7207(01)00699-2, vol. 187, no. 1-2, 1 January 2002 (2002-01-01), pages 11 - 18, XP003007518, ISSN: 0303-7207 *
GILCHRIST R B ET AL: "Oocyte-somatic cell interactions during follicle development in mammals", ANIMAL REPRODUCTION SCIENCE, vol. 82-83, 1 January 2004 (2004-01-01), ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, pages 431 - 446, XP003007519, ISSN: 0378-4320, DOI: 10.1016/J.ANIREPROSCI.2004.05.017 *
HAYASHI MASARU ET AL: "Recombinant Growth Differentiation Factor-9 (GDF-9) enhances growth and differentiation of cultured early ovarian follicles", ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 140, no. 3, 1 March 1999 (1999-03-01), pages 1236 - 1244, XP002133258, ISSN: 0013-7227 *
ISOBE N ET AL: "Cumulus cells suppress meiotic progression in pig oocytes cultured in vitro", THERIOGENOLOGY, vol. 45, no. 8, 1996, pages 1479 - 1489, XP002534034, ISSN: 0093-691X *
KOBAYASHI K ET AL: "Influence of epidermal growth factor and transforming growth factor-[alpha] on in vitro maturation of cumulus cell-enclosed bovine oocytes in a defined medium", JOURNAL OF REPRODUCTION AND FERTILITY, JOURNALS OF REPRODUCTION AND FERTILITY LTD, GB, vol. 100, no. 2, 1 January 1994 (1994-01-01), pages 439 - 446, XP009139816, ISSN: 0022-4251 *
LUCIANO ALBERTO M ET AL: "Developmental capability of denuded bovine oocyte in a co-culture system with intact cumulus-oocyte complexes: role of cumulus cells, cyclic adenosine 3 ',5 '-monophosphate, and glutathione", MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 71, no. 3, April 2005 (2005-04-01), pages 389 - 397, XP002534033, ISSN: 1040-452X *
MCNATTY K P ET AL: "Bone morphogenic protein 15 and growth differentiation factor 9 co-operate to regulate granulosa cell function in ruminants", REPRODUCTION, BIOSCIENTIFICA LTD, GB, vol. 129, no. 4, 1 April 2005 (2005-04-01), pages 481 - 487, XP003007516, ISSN: 1470-1626, DOI: 10.1530/REP.1.00517 *
SAKAKIBARA HIDEO ET AL: "Effect of growth factors in the medium for oocyte maturation and embryo culture on the development of in vitro matured and fertilized bovine oocytes", JAPANESE JOURNAL OF EMBROYO TRANSFER, 1 January 1999 (1999-01-01) - 1 January 1999 (1999-01-01), Japan, pages - 74, XP002604697, ISSN: 1341-2965, Retrieved from the Internet <URL:http://sciencelinks.jp/j-east/article/200003/000020000399A0690111.php> [retrieved on 20101012] *
SENBON S ET AL: "INTERACTIONS BETWEEN THE OOCYTE AND SURROUNDING SOMATIC CELLS IN FOLLICULAR DEVELOPMENT: LESSONS FROM IN VITRO CULTURE", JOURNAL OF REPRODUCTION AND DEVELOPMENT, FUCHU, JP, vol. 49, no. 4, 1 August 2003 (2003-08-01), pages 259 - 269, XP002589120, ISSN: 0916-8818, DOI: 10.1262/JRD.49.259 *
SU Y-Q ET AL: "Synergistic roles of BMP15 and GDF9 in the development and function of the oocyte-cumulus cell complex in mice: genetic evidence for an oocyte-granulosa cell regulatory loop", DEVELOPMENTAL BIOLOGY, vol. 276, no. 1, 1 December 2004 (2004-12-01), ACADEMIC PRESS, NEW YORK, NY, US, pages 64 - 73, XP004630528, ISSN: 0012-1606, DOI: 10.1016/J.YDBIO.2004.08.020 *
YAN C ET AL: "SYNERGISTIC ROLES OF BONE MORPHOGENETIC PROTEIN 15 AND GROWTH DIFFERENTIATION FACTOR 9 IN OVARIAN FUNCTION", MOLECULAR ENDOCRINOLOGY, THE ENDOCRINE SOCIETY, US, vol. 15, no. 6, 1 June 2001 (2001-06-01), pages 854 - 866, XP001057927, ISSN: 0888-8809, DOI: 10.1210/ME.15.6.854 *

Also Published As

Publication number Publication date
EP2228070B1 (fr) 2016-09-07
US20080274963A1 (en) 2008-11-06
KR101502110B1 (ko) 2015-03-12
KR20080043783A (ko) 2008-05-19
CA2615006A1 (fr) 2007-01-25
JP2013215207A (ja) 2013-10-24
US20140073052A1 (en) 2014-03-13
JP2009501533A (ja) 2009-01-22
EP1909820A1 (fr) 2008-04-16
CN101272804A (zh) 2008-09-24
JP5841973B2 (ja) 2016-01-13
DK2228070T3 (da) 2017-01-02
US8530235B2 (en) 2013-09-10
WO2007009166A1 (fr) 2007-01-25
EP1909820A4 (fr) 2009-08-12
EP2228070A2 (fr) 2010-09-15

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