EP2187992A2 - Procédé permettant de contrôler et/ou de surveiller le fonctionnement correct d'un dispositif d'addition - Google Patents

Procédé permettant de contrôler et/ou de surveiller le fonctionnement correct d'un dispositif d'addition

Info

Publication number
EP2187992A2
EP2187992A2 EP08801719A EP08801719A EP2187992A2 EP 2187992 A2 EP2187992 A2 EP 2187992A2 EP 08801719 A EP08801719 A EP 08801719A EP 08801719 A EP08801719 A EP 08801719A EP 2187992 A2 EP2187992 A2 EP 2187992A2
Authority
EP
European Patent Office
Prior art keywords
characteristic
extracorporeal circuit
adding device
medical device
waveform
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08801719A
Other languages
German (de)
English (en)
Other versions
EP2187992B1 (fr
Inventor
Pascal Kopperschmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Medical Care Deutschland GmbH
Original Assignee
Fresenius Medical Care Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Medical Care Deutschland GmbH filed Critical Fresenius Medical Care Deutschland GmbH
Publication of EP2187992A2 publication Critical patent/EP2187992A2/fr
Application granted granted Critical
Publication of EP2187992B1 publication Critical patent/EP2187992B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3672—Means preventing coagulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/16854—Monitoring, detecting, signalling or eliminating infusion flow anomalies by monitoring line pressure
    • A61M5/16859—Evaluation of pressure response, e.g. to an applied pulse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3639—Blood pressure control, pressure transducers specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/14—Detection of the presence or absence of a tube, a connector or a container in an apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow

Definitions

  • the present invention relates to a method for checking and / or monitoring the correct function of a delivery device of a medical device, wherein the medical device has an extracorporeal circuit, with which the adding device is connected in such a way that means by means of the adding device inserted into the extracorporeal circuit is.
  • the medical device may be a dialysis machine, in which - as in other extracorporeal procedures - the blood is an anticoagulant such. B. heparin or citrate must be added.
  • the medical device has an adding device, usually in the form of a syringe pump, which contains the agent to be added.
  • the delivery device is connected to the extracorporeal circulation, i. H. with an extracorporeal tube set, connected.
  • a syringe with the agent is first inserted into the syringe pump and connected to the extracorporeal circuit.
  • a plunger is provided, which the syringe Stempe! into the syringe.
  • the bumps! For this purpose is moved accordingly via a spindle and a spindle drive.
  • the monitoring of the dose administered by such an adding device takes place z. B. during dialysis treatment on the measurement of the plunger displacement, z. B. by the sampling by means of a resistive track. In this way, the distance traveled by the delivery tappet and thus the amount added can be calculated.
  • the correct addition is checked only on the side of the syringe pump, while it is not ensured whether the amount of anticoagulant to be infused actually arrives in the extracorporeal circulation. Although it is initially checked in known devices at the beginning of treatment, if the syringe pump is connected correctly. However, during the duration of the treatment, disconnection or other malfunction would not be automatically detectable.
  • the object of the present invention is therefore to provide an improved method for checking and / or monitoring the correct function of an adding device.
  • this method should make it possible to be able to directly check the correct function of the adding device even during operation.
  • this object is achieved by a method according to claim 1.
  • a characteristic waveform in the extracorporeal circuit is detected, wherein the adding device detects the characteristic signal History generated.
  • Vorteühaft tone a waveform in the extracorporeal blood circulation is measured and evaluated for checking and / or monitoring the correct function of the adding device.
  • a characteristic waveform is detected when the adding device works correctly and generates it, so that a direct check and / or monitoring is possible. By checking whether a characteristic signal is actually present, it is possible to directly monitor whether the adding device works correctly.
  • the adding device is not correctly coupled or if there are other problems which prevent the correct addition of liquid from the adding device into the extracorporeal circuit, then no characteristic signal curve is generated therein, so that the malfunction of the adding device can be reliably detected.
  • the indirect review eg B. be used by the plunger movement of a syringe pump, but the correct function can be measured directly.
  • the characteristic signal profile can also be generated and detected during the ongoing operation of the medical device, so that continuous monitoring becomes possible via the method according to the invention.
  • the characteristic signal curve is a characteristic pressure curve.
  • the adding device generates the characteristic pressure curve in the extracorporeal circuit, which can then be detected in order to check and / or monitor the correct function of the adding device.
  • the characteristic signal curve is detected in the electrical parameters, in particular in the drive current, of a pump arranged in the extracorporeal circuit which pumps fluid through the extracorporeal circuit. Also in these electrical parameters, a characteristic signal which is generated by means of the adding device can be detected. In this case, a characteristic pressure curve generated by the adding device would no longer be measured directly, but indirectly as a characteristic Waveform detected in the electrical parameters of the arranged in the extracorporeal circuit pump.
  • the characteristic signal characteristic according to the invention exhibits a repeated alternating rise and fall of the signal, in particular a plurality of successive pulse-shaped signals.
  • the checking and / or monitoring of the correct function of the adding device can be ensured safely and reliably.
  • the characteristic signal curve has an oscillating profile.
  • an oscillating waveform By such an oscillating waveform, the characteristic signal can be easily and reliably detected.
  • Such an oscillating signal course in particular an oscillating pressure curve, can be generated particularly easily by the adding device, and is particularly easy to detect, even if the area in which the adding device introduces means into the extracorporeal circuit is not completed but open , eg during operation of the medical device.
  • the characteristic, advantageously oscillating waveform with correct function of the adding device is advantageously based on the fact that the delivery rate of the adding device varies over time. So z. B. conceivable that the addition is clocked, which can lead to corresponding pressure fluctuations in the extracorporeal circuit. In particular, when only very small amounts of liquid to be infused, a clocked addition is usually not sufficient to produce a measurable oscillating waveform, for example in the form of an oscillating pressure curve over which the correct function of the adding device could be reliably detected.
  • the characteristic waveform is generated by a corresponding, in particular multiple, in particular oscillating operation of the adding device, through which the extracorporeal blood circuit alternating liquid is added and withdrawn. This allows a clear characteristic signal to be generated, which can be reliably detected.
  • the volumes moved during the in particular multiple, in particular oscillating actuation of the adding device are less than one milliliter. This can ensure that the concentration fluctuations of the added agent are kept small. Nevertheless, this oscillating pressure fluctuations can be generated, which can be clearly recognized in the pressure signal.
  • a continuous movement of the adding device, via which the agent is added into the extracorporeal circuit is superimposed on a corresponding characteristic, in particular oscillating, movement for generating the characteristic, in particular characteristic signal course.
  • a characteristic signal course is detected in the extracorporeal blood circulation, this means that the adding device is correctly coupled to the extracorporeal circuit and functions, so that the liquid added by the continuous movement of the adding device actually arrives in the extracorporeal circuit. If, on the other hand, no characteristic signal profile is detected, this means that no liquid is added.
  • the signal curve for checking or monitoring the correct function of the adding device is also measured over several pulses, in particular over several periods of the oscillation.
  • the oscillation is carried out according to the invention with a constant over at least a period of time period.
  • the characteristic, in particular oscillating waveform is thereby inventively detected in the signal of a pressure sensor.
  • a characteristic pressure profile can be detected directly and easily in order to check and / or monitor the correct function of the adding device.
  • the characteristic, in particular oscillating, waveform can also be detected in the electrical parameters, in particular in the drive current, of a pump arranged in the extracorporeal circuit, which pumps fluid through the extracorporeal circuit. Even so, a characteristic signal course can be detected reliably, wherein optionally a pressure sensor can be dispensed with.
  • a pressure sensor can be dispensed with.
  • this z. B be operated with a higher or lower current. This change in the current consumption can be detected, and evaluated in connection with the supply of the characteristic signal waveform. In the event of a fault (infusion line not connected correctly or syringe inserted incorrectly) then no characteristic signal curve is detected accordingly.
  • the characteristic, in particular oscillating waveform is detected by means of a signal analysis, in particular a frequency analysis.
  • a frequency analysis can be z. B. via known methods such. B. carried out a Fourier transform.
  • the actuation of the adding device as a whole leads to an addition of the agent into the extracorporeal circulation.
  • the determination of the added amount of the agent in the time average of the movement of the adding device can then continue to be done as in the prior art via a transmitter on the adding device, via whose measured values, the added amount is determined indirectly.
  • the fact that this amount actually arrived in the extracorporeal circuit is, on the other hand, According to the recognized over the characteristic waveform, such as an oscillating pressure curve.
  • the monitoring according to the invention of the correct function of the adding device takes place continuously during the addition of the agent into the extracorporeal circulation.
  • Such permanent monitoring is provided by the characteristic and, in particular, oscillating waveform, e.g. an oscillating pressure curve, which can also be generated and detected during the ongoing operation of the medical device possible.
  • the checking and / or monitoring of the adding device takes place while fluid flows through the extracorporeal circuit, in particular while fluid is pumped through it by means of a pump arranged in the extracorporeal circuit.
  • the checking and / or monitoring of the adding device takes place during the ongoing operation of the medical device.
  • the safety in the therapy can be significantly increased, since now for the first time a direct monitoring during operation is possible.
  • the operation of the medical device is interrupted and / or a warning signal is generated when a malfunction of the feeder is detected. This ensures that the errors z. B. be corrected immediately in the coupling of the adding device.
  • the added agent is advantageously an anticoagulant, a medicament or another agent to be infused, which is added to the extracorporeal circulation.
  • the anticoagulant is heparin.
  • the adding device according to the invention is a syringe pump with a syringe inserted therein.
  • a syringe pump is particularly well suited for the addition.
  • the characteristic, in particular oscillating waveform is generated.
  • the method sequences according to the invention are controlled by means of a control device of the medical device.
  • these procedures are advantageously generated automatically by the control device.
  • the present invention furthermore comprises a medical device, preferably a dialysis machine, suitable for receiving an extracorporeal circuit, with an adding device which can be connected to the extracorporeal circuit such that a means can be introduced into the extracorporeal circuit by means of the adding device.
  • this medical device has a control device which activates the adding device in such a way that it generates a characteristic signal curve in the extracorporeal circuit, wherein the characteristic signal curve is detected.
  • Vorteühaft clip evaluates the control of a waveform, in particular a waveform in the extracorporeal circuit. By means of this evaluation of the signal curve, a characteristic signal profile, as generated by the controller advantageously via the control of the adding device, can be detected in order to check and / or monitor the correct function of the adding device.
  • control of the medical device according to the invention is designed so that it carries out one of the above-described inventive method.
  • the controller advantageously carries out one of these methods automatically.
  • the adding device of the medical device is a syringe pump, into which a syringe can be inserted, so that the plunger of the syringe can be moved via a plunger.
  • the control generates a characteristic, in particular oscillating movement of the plunger. If the syringe is correctly inserted and connected, this movement of the plunger generates a corresponding, characteristic, in particular oscillating movement of the syringe plunger, which in turn produces a characteristic signal curve, in particular an oscillating pressure curve in the extracorporeal circuit.
  • the correct function of the syringe pump can be monitored, which in turn is done automatically via the controller.
  • the movement of the plunger is measured.
  • This movement of the plunger then calculates the amount infused, as known in the art.
  • the syringe pump for this purpose a corresponding transmitter, z. B. a resistance on.
  • the medical device has a pressure sensor for measuring the pressure curve in the extracorporeal circuit.
  • this pressure sensor may be an already provided in the medical device pressure sensor, for. B. to the arterial pressure measuring unit.
  • the medical device has a pump for transporting fluid in the extracorporeal blood circulation.
  • the adding device is connectable to the arterial line of a blood tubing set for an extracorporeal blood treatment procedure.
  • the arterial pressure measuring unit is usually provided, so that only the control of the medical device must be adjusted accordingly for carrying out the method according to the invention, but otherwise no structural changes must be made.
  • the medical device according to the invention is a medical device for dialysis, hemodialysis, hemofiltration, hemodiafiltration, for adsorptive blood purification, in the transfusion method or in the autotransfusion method.
  • the monitoring and / or verification of the correct function of the delivery device according to the invention can significantly increase the safety of the treatment.
  • the present invention therefore encompasses the use of a medical device according to the invention in dialysis, hemodialysis, hemofiltration, hemodiafiltration, for absorptive blood purification, in the transfusion method or in the autotransfusion method.
  • the present invention further comprises an adding device, in particular a syringe pump for adding a medical fluid into a line, in particular into an extracorporeal circuit or an infusion tube.
  • this adding device has a control which controls the adding device in such a way that it has a characteristic signal curve in FIG the line is generated, wherein means are provided for detecting the characteristic waveform.
  • the inventive adding device with the corresponding control for monitoring and / or checking the correct function of the adding device can thus also be used independently of the medical device according to the invention with great advantage.
  • the adding device can also be used to monitor an infusion.
  • the adding device or the control of the adding device is designed so that it carries out one of the methods described above.
  • Figure 1 an embodiment of an adding device according to the invention
  • FIG. 2 shows a diagram of a pressure curve during an embodiment of the method according to the invention.
  • FIG. 1 shows an exemplary embodiment of an adding device according to the invention, in this case a syringe pump.
  • a syringe 1 is inserted into a holder 5, so that the syringe plunger 2 of the syringe 1 can be moved via the plunger 4.
  • the syringe plunger 2 is thereby connected to the plunger 4, that the syringe plunger can be both pressed into the syringe and pulled out of the syringe.
  • the plunger 4 itself is moved back and forth via a spindle 3, which is driven by a spindle drive 6.
  • a resistive track not shown, is provided, so that on the measurement of the delivery shocks! traveled way the volume delivery via the syringe 1 can be determined.
  • the adding device according to the invention is part of a medical device according to the invention, in particular a dialysis machine.
  • an extracorporeal circuit is used, in particular in the form of a blood tubing set.
  • the syringe 1 is then connected when inserting via a line 7 to the extracorporeal circuit, z. B. with the arterial line of the blood tubing set.
  • anticoagulant such as b. Heparin or citrate, which is applied to the syringe 1, are continuously added to the blood flowing through the extracorporeal circuit.
  • the control of the medical device according to the invention is designed so that initially the correct coupling of the syringe to the extracorporeal circuit is initially checked before the start of the treatment. This can already be done by the method according to the invention, but at the beginning of the treatment, alternative process options are known.
  • the method according to the invention is now carried out automatically in the medical device according to the invention via the controller.
  • the continuous movement of the plunger 4 for continuous infusion is superimposed on a characteristic, movement, which is oscillating in the embodiment.
  • this oscillating movement of the plunger With correct functioning of all components, this oscillating movement of the plunger generates an oscillating pressure curve in the extracorporeal circuit.
  • the amplitude of the pressure oscillation depends on the system compliance and on the size of the plunger movement.
  • the volumes moved during the oscillation are less than one milliliter and thus lead to only minimal fluctuations in the concentration of the added agent in the extracorporeal circulation, but nevertheless lead to well measurable and recognizable pressure fluctuations.
  • a pressure sensor z. B. measured in the arterial line, the pressure in the extracorporeal circuit and evaluated accordingly.
  • the identification of the oscillation in the pressure curve is feasible at a known period with conventional signal analysis.
  • a frequency analysis z. B. be used via a Fourier transform.
  • FIG. 2 shows such a pressure curve in the mean arterial pressure.
  • the adding device initially operates correctly in the left-hand area of the diagram, so that an oscillation in the course of the pressure can be recognized. This is detected via signal analysis and allows the medical device controller to monitor the correct operation of the adding device. However, as in the right section of the diagram, if there is an error in the function of the adding device, the pressure profile is not superimposed with an oscillation. Such a signal would result in a wrong inserted syringe 1, in which the plunger 4 would not move the syringe die 2. Likewise, there would be no oscillating signal in the pressure curve, if no correct coupling between the syringe 1 and the extracorporeal circuit vorläge.
  • the control of the medical device according to the invention now recognizes that there is no oscillation in the pressure signal. If such a lack of oscillation is detected even though the adding device is operated, a malfunction is judged. The controller then activates a warning function, e.g. B. via an optical or acoustic signal. Thus it can be prevented that there is too little addition of infusion agents due to a malfunction of the adding device. In a further embodiment or in special cases, the control unit can also stop the medical device automatically.
  • a warning function e.g. B. via an optical or acoustic signal.
  • the first time it is possible for the first time to check the correct function of the adding device during the operation of the medical device, ie during the actual treatment.
  • the pressure fluctuations in the pressure curve caused by the oscillating movements of the plunger even if fluid flows through the extracorporeal circuit, especially even when blood is pumped by a blood pump through the extracorporeal circuit.
  • the pressure sensor via which the pressure curve in the extracorporeal blood circulation is measured, for this purpose arranged on the same side of a blood pump as the adding device.
  • the addition device and pressure sensor are arranged one behind the other on the suction side of a pump in the extracorporeal circuit.
  • the electrical parameters of the blood pump such as their power consumption, current or voltage, which are influenced by the oscillating pressure pulses, can also be used for detection and evaluation.
  • the continuous monitoring of the infusion delivery rate consists on the one hand of ensuring the correct function of the adding device, in particular the correct coupling between syringe 1 and plunger 4 and the correct coupling of the syringe 1 to the extracorporeal circuit by the present invention.
  • the monitoring also includes a measurement of the amount of infusion administered within a certain time. This is realized via the sampling of the plunger displacement with its resistance track as in the prior art.

Abstract

La présente invention concerne un procédé permettant de contrôler et/ou de surveiller le fonctionnement correct d'un dispositif d'addition d'un appareil médical. L'appareil médical comprend un circuit de circulation extracorporelle auquel le dispositif d'addition est raccordé de manière qu'un agent puisse être introduit dans le circuit de circulation extracorporelle au moyen du dispositif d'addition. L'allure de la pression dans le circuit de circulation extracorporelle est mesurée et analysée afin de contrôler et/ou de surveiller le fonctionnement correct du dispositif d'addition. Selon l'invention, le dispositif d'addition génère une allure de pression oscillante à cette fin.
EP08801719.9A 2007-09-18 2008-08-26 Procédé permettant de contrôler et/ou de surveiller le fonctionnement correct d'un dispositif d'addition Active EP2187992B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007044413A DE102007044413A1 (de) 2007-09-18 2007-09-18 Verfahren zur Überprüfung und/oder Überwachung der korrekten Funktion einer Zugabevorrichtung
PCT/EP2008/006990 WO2009036866A2 (fr) 2007-09-18 2008-08-26 Procédé permettant de contrôler et/ou de surveiller le fonctionnement correct d'un dispositif d'addition

Publications (2)

Publication Number Publication Date
EP2187992A2 true EP2187992A2 (fr) 2010-05-26
EP2187992B1 EP2187992B1 (fr) 2018-08-01

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Application Number Title Priority Date Filing Date
EP08801719.9A Active EP2187992B1 (fr) 2007-09-18 2008-08-26 Procédé permettant de contrôler et/ou de surveiller le fonctionnement correct d'un dispositif d'addition

Country Status (6)

Country Link
US (1) US8715215B2 (fr)
EP (1) EP2187992B1 (fr)
JP (1) JP5557742B2 (fr)
CN (1) CN101835504B (fr)
DE (1) DE102007044413A1 (fr)
WO (1) WO2009036866A2 (fr)

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Also Published As

Publication number Publication date
CN101835504A (zh) 2010-09-15
WO2009036866A3 (fr) 2009-07-16
US20100204633A1 (en) 2010-08-12
JP5557742B2 (ja) 2014-07-23
WO2009036866A2 (fr) 2009-03-26
DE102007044413A1 (de) 2009-03-19
JP2010538779A (ja) 2010-12-16
CN101835504B (zh) 2014-08-06
US8715215B2 (en) 2014-05-06
EP2187992B1 (fr) 2018-08-01

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