EP2170064A4 - 6,5-pyrrolopiperidine tachykinin receptor antagonists - Google Patents
6,5-pyrrolopiperidine tachykinin receptor antagonistsInfo
- Publication number
- EP2170064A4 EP2170064A4 EP08771300A EP08771300A EP2170064A4 EP 2170064 A4 EP2170064 A4 EP 2170064A4 EP 08771300 A EP08771300 A EP 08771300A EP 08771300 A EP08771300 A EP 08771300A EP 2170064 A4 EP2170064 A4 EP 2170064A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- pyrrolopiperidine
- receptor antagonists
- tachykinin receptor
- tachykinin
- antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93686407P | 2007-06-22 | 2007-06-22 | |
PCT/US2008/067270 WO2009002770A1 (en) | 2007-06-22 | 2008-06-18 | 6.5-pyrrolopiperidine tachykinin receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2170064A1 EP2170064A1 (en) | 2010-04-07 |
EP2170064A4 true EP2170064A4 (en) | 2010-08-04 |
Family
ID=40185984
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP08771300A Withdrawn EP2170064A4 (en) | 2007-06-22 | 2008-06-18 | 6,5-pyrrolopiperidine tachykinin receptor antagonists |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2170064A4 (ja) |
JP (1) | JP2010530874A (ja) |
AU (1) | AU2008268667A1 (ja) |
CA (1) | CA2690737A1 (ja) |
WO (1) | WO2009002770A1 (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101074202B1 (ko) * | 2007-01-18 | 2011-10-14 | 에스케이종합화학 주식회사 | 에틸렌 사량체화 촉매계 및 이를 이용한 1-옥텐의 제조방법 |
PT2501234T (pt) | 2009-11-20 | 2017-12-13 | Tonix Pharma Holdings Ltd | Métodos e composições para o tratamento de sintomas associados com distúrbios de stress pós-traumático utilizando ciclobenzaprina |
US20110319389A1 (en) | 2010-06-24 | 2011-12-29 | Tonix Pharmaceuticals, Inc. | Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine |
US11998516B2 (en) | 2011-03-07 | 2024-06-04 | Tonix Pharma Holdings Limited | Methods and compositions for treating depression using cyclobenzaprine |
WO2013004766A1 (en) | 2011-07-04 | 2013-01-10 | Ferrari Giulio | Nk-1 receptor antagonists for treating corneal neovascularisation |
CN104245702B (zh) | 2012-02-22 | 2016-09-14 | 利奥制药有限公司 | 新型神经激肽1受体拮抗剂化合物 |
AR092211A1 (es) * | 2012-09-24 | 2015-04-08 | Merck Patent Ges Mit Beschränkter Haftung | Derivados de hidropirrolopirrol |
BR112015022095B1 (pt) | 2013-03-15 | 2021-12-07 | Tonix Pharmaceuticals, Inc | Composição farmacêutica, métodos de fabricação, composição eutética e uso de composições |
WO2015024203A1 (en) | 2013-08-20 | 2015-02-26 | Leo Pharma A/S | Novel neurokinin 1 receptor antagonist compounds ii |
CN105579456A (zh) * | 2013-08-20 | 2016-05-11 | 利奥制药有限公司 | 新型神经激肽1受体拮抗剂化合物ii |
CN107072968B (zh) | 2014-09-18 | 2021-01-12 | 通尼克斯制药控股有限公司 | 环苯扎林盐酸盐的低共熔混合物配制剂 |
CN111447971A (zh) | 2017-12-11 | 2020-07-24 | 通尼克斯制药控股有限公司 | 用于痴呆和神经变性病况中的激越、精神病和认知衰退的环苯扎林治疗 |
CA3091944A1 (en) | 2018-02-26 | 2019-08-29 | Ospedale San Raffaele S.R.L. | Nk-1 antagonists for use in the treatment of ocular pain |
US20230134843A1 (en) | 2020-03-11 | 2023-05-04 | Ospedale San Raffaele S.R.L. | Treatment of stem cell deficiency |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004110996A1 (en) * | 2003-06-19 | 2004-12-23 | Pfizer Products Inc. | Nk1 antagonist |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0203020D0 (en) * | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
EP1827420A4 (en) * | 2004-12-14 | 2009-03-04 | Merck & Co Inc | OCTAHYDROPYRANO [3,4-c] pyrrole tachykinin receptor Antagonist |
-
2008
- 2008-06-18 WO PCT/US2008/067270 patent/WO2009002770A1/en active Application Filing
- 2008-06-18 CA CA2690737A patent/CA2690737A1/en not_active Abandoned
- 2008-06-18 EP EP08771300A patent/EP2170064A4/en not_active Withdrawn
- 2008-06-18 JP JP2010513364A patent/JP2010530874A/ja not_active Withdrawn
- 2008-06-18 AU AU2008268667A patent/AU2008268667A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004110996A1 (en) * | 2003-06-19 | 2004-12-23 | Pfizer Products Inc. | Nk1 antagonist |
Non-Patent Citations (1)
Title |
---|
See also references of WO2009002770A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP2170064A1 (en) | 2010-04-07 |
JP2010530874A (ja) | 2010-09-16 |
WO2009002770A1 (en) | 2008-12-31 |
CA2690737A1 (en) | 2008-12-31 |
AU2008268667A1 (en) | 2008-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20100122 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA MK RS |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20100707 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 25/24 20060101ALI20100701BHEP Ipc: A61P 25/22 20060101ALI20100701BHEP Ipc: A61P 25/06 20060101ALI20100701BHEP Ipc: A61P 13/00 20060101ALI20100701BHEP Ipc: A61K 31/437 20060101ALI20100701BHEP Ipc: C07D 471/04 20060101AFI20100701BHEP |
|
DAX | Request for extension of the european patent (deleted) | ||
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20110207 |