EP2164362A1 - Brosse à dents à longues soies effilées et courtes soies non effilées - Google Patents

Brosse à dents à longues soies effilées et courtes soies non effilées

Info

Publication number
EP2164362A1
EP2164362A1 EP08774385A EP08774385A EP2164362A1 EP 2164362 A1 EP2164362 A1 EP 2164362A1 EP 08774385 A EP08774385 A EP 08774385A EP 08774385 A EP08774385 A EP 08774385A EP 2164362 A1 EP2164362 A1 EP 2164362A1
Authority
EP
European Patent Office
Prior art keywords
bristles
bristle
longer
tufts
shorter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08774385A
Other languages
German (de)
English (en)
Inventor
Hans Kraemer
John Binet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Consumer Healthcare GmbH and Co KG
Original Assignee
GlaxoSmithKline Consumer Healthcare GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0712646A external-priority patent/GB0712646D0/en
Priority claimed from GB0712642A external-priority patent/GB0712642D0/en
Application filed by GlaxoSmithKline Consumer Healthcare GmbH and Co KG filed Critical GlaxoSmithKline Consumer Healthcare GmbH and Co KG
Publication of EP2164362A1 publication Critical patent/EP2164362A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A46BRUSHWARE
    • A46BBRUSHES
    • A46B9/00Arrangements of the bristles in the brush body
    • A46B9/02Position or arrangement of bristles in relation to surface of the brush body, e.g. inclined, in rows, in groups
    • A46B9/04Arranged like in or for toothbrushes
    • AHUMAN NECESSITIES
    • A46BRUSHWARE
    • A46BBRUSHES
    • A46B9/00Arrangements of the bristles in the brush body
    • A46B9/02Position or arrangement of bristles in relation to surface of the brush body, e.g. inclined, in rows, in groups
    • A46B9/028Bristle profile, the end of the bristle defining a surface other than a single plane or deviating from a simple geometric form, e.g. cylinder, sphere or cone
    • AHUMAN NECESSITIES
    • A46BRUSHWARE
    • A46DMANUFACTURE OF BRUSHES
    • A46D1/00Bristles; Selection of materials for bristles
    • AHUMAN NECESSITIES
    • A46BRUSHWARE
    • A46DMANUFACTURE OF BRUSHES
    • A46D1/00Bristles; Selection of materials for bristles
    • A46D1/02Bristles details
    • A46D1/0276Bristles having pointed ends
    • AHUMAN NECESSITIES
    • A46BRUSHWARE
    • A46BBRUSHES
    • A46B15/00Other brushes; Brushes with additional arrangements
    • A46B15/0055Brushes combined with other articles normally separate from the brushing process, e.g. combs, razors, mirrors
    • A46B15/0069Brushes fitted with a interdental devices, e.g. toothpick
    • A46B15/0071Toothbrushes with flossing arrangements
    • AHUMAN NECESSITIES
    • A46BRUSHWARE
    • A46BBRUSHES
    • A46B2200/00Brushes characterized by their functions, uses or applications
    • A46B2200/10For human or animal care
    • A46B2200/1066Toothbrush for cleaning the teeth or dentures

Definitions

  • Toothbrushes are well known articles generally comprising a head for insertion in the user's mouth and a grip handle to be held during use, with often a neck region in between.
  • the toothbrush head normally has a surface, termed herein the "bristle surface” from which bristles extend from a lower end closest to the bristle surface to an upper end distant from the bristle surface.
  • Toothbrush bristles are also well known articles, generally comprising a filament of a stiff but flexible material, disposed in tufts of plural filaments extending from the bristle surface.
  • the polyamide Nylon is very frequently used as a toothbrush bristle material.
  • the bristle filaments have the same cross- section along their entire length from their lower to their upper end, it is also known to use tapered bristles which decrease in their cross section toward their upper end. Tapered bristles, being thinner at their upper end, have different bending and flexibility characteristics to non-tapered filaments. In particular tapered bristles are known for efficacy in reaching into the spaces between the teeth, the so called "interproximal" spaces.
  • each tuft comprises plural bristle filaments made of polybutylene terephthalate in the form of shorter filaments of uniform cross section and longer filaments which taper toward their upper end. It is also known from other disclosures to combine long and short bristle filaments in a tuft e.g. US-A-3, 103,679, WO-A-96/16571 and DE-A-35 28 596.
  • a toothbrush head having a bristle surface from which tufts comprising plural bristles extend in a bristle direction, each tuft comprising shorter bristles having a cross section which does not taper from their lower end toward their upper end and longer bristles which taper from their lower end toward their upper end, the taper of the longer bristles commencing above the upper ends of the shorter bristles, and wherein the length of the longer bristles above the upper ends of the shorter bristles is from 4 mm up to 7mm.
  • a toothbrush head with the length of the longer, tapered bristles, bristles above the upper ends of the shorter bristles being from 4 mm up to 7mm facilitates manufacture of the toothbrush head by mechanical abrasion of the upper ends of the longer bristles, particularly in the case when the bristle filaments are made of the preferred polyamide, e.g. Nylon, particularly the material TynexTM.
  • the bristle filaments are made of the preferred polyamide, e.g. Nylon, particularly the material TynexTM.
  • the length of the longer bristles above the upper ends of the shorter bristles is from >4 mm up to 7mm.
  • the length to which the shorter bristles extend from the bristle surface is 9 +/- lmm and length to which the shorter bristles extend from the bristle surface is 13 +/- lmm.
  • the filaments may be circular in cross section, typically 0.1 - 0.25 mm, e.g. 0.15 - 0.20 mm, at maximum. This is a typical standard dimension for toothbrush bristle filaments.
  • the longer bristles may taper over the entirety of their length above the upper end of the shorter bristles.
  • a toothbrush head having a bristle surface from which tufts comprising plural bristles extend in a bristle direction, each tuft comprising shorter bristles having a cross section which does not taper from their lower end toward their upper end and longer bristles which taper from their lower end toward their upper end, the taper of the longer bristles commencing above the upper ends of the shorter bristles, and wherein each said tuft is set in a tuft socket having a minimum dimension across the longitudinal direction of the bristle filaments in the range 1.7 - 2.4 mm.
  • toothbrush tuft sockets in this dimension range, typically being circular and having its diameter in this range, is advantageous for the combination of shorter and longer bristles in the tufts. This is believed to be because such a dimension enables a packing density which enables the shorter bristles to support the longer bristles for an advantageous tooth-cleaning effect, longer filaments being more flexible than shorter filaments for the same applied force. In particular this is found to be the case with the tufts of the toothbrush head of the first aspect of this invention.
  • toothbrush tuft sockets have a standard depth of 3.4 - 3.8 mm.
  • a tuft socket depth of 3.6 mm has been found suitable for the tufts of the toothbrush head of the first aspect of this invention.
  • a toothbrush head having a bristle surface from which tufts comprising plural bristles extend in a bristle direction, each tuft comprising shorter bristles having a cross section which does not taper from their lower end toward their upper end and longer bristles which taper from their lower end toward their upper end, the taper of the longer bristles commencing above the upper ends of the shorter bristles, each tuft containing 2 - 12 longer filaments extending from the bristle surface.
  • this range of numbers of bristle filaments in the tufts can be advantageous in providing an acceptable mouth feel and in getting the longer bristles in between the teeth. Too few longer bristle filaments may not feel comfortable to the user, too many and it may not be easy to get a larger number of the longer filaments between the teeth.
  • 5 - 7 longer filaments preferably 26 - 28 shorter filaments and 5 - 7 longer filaments is a suitable number for an optimized effect.
  • a toothbrush head having a bristle surface from which tufts comprising plural bristles extend in a bristle direction, each tuft comprising shorter bristles having a cross section which does not taper from their lower end toward their upper end and longer bristles which taper from their lower end toward their upper end, the taper of the longer bristles commencing above the upper ends of the shorter bristles, and wherein the length of the longer bristles above the upper ends of the shorter bristles is from 4 mm up to 7mm, and wherein each tuft contains 2 - 12 longer filaments extending from the bristle surface.
  • a toothbrush head having a bristle surface from which tufts comprising plural bristles extend in a bristle direction, each tuft comprising shorter bristles having a cross section which does not taper from their lower end toward their upper end and longer bristles which taper from their lower end toward their upper end, the taper of the longer bristles commencing above the upper ends of the shorter bristles, and wherein the length of the longer bristles above the upper ends of the shorter bristles is from 4 mm up to 7 mm, wherein each said tuft is set in a tuft socket having a minimum dimension in the range 1.7 - 2.4 mm, and wherein each tuft contains 20 - 30 shorter bristle filaments and 2 - 12 longer filaments extending from the bristle surface.
  • the shorter and longer bristle filaments may be disposed in various ways.
  • the longer tufts may be disposed randomly among the shorter bristle filaments.
  • the longer bristles may be disposed about the central upper-lower axis of the tuft, e.g. as a central region comprising predominantly or entirely of the longer bristles.
  • the said tufts may be disposed on the bristle surface in a pattern which is otherwise generally conventional.
  • the said tuft comprising shorter bristles having a cross section which does not taper from their lower end toward their upper end and longer bristles which taper from their lower end toward their upper end, the taper of the longer bristles commencing above the upper ends of the shorter bristles may be disposed on the bristle surface in a pattern comprising an inner cluster of said tufts flanked on each longitudinal side by tufts comprised only of said shorter bristle filaments. Further, in such a pattern the inner cluster of said tufts may be surrounded on all sides by tufts comprised only of said shorter bristle filaments.
  • bristle tufts of known types e.g. of commonplace types made of known materials such as Nylon e.g. TynexTM.
  • tooth- or gum- hygiene elements extending from the bristle surface, e.g. known types of elastomeric elements.
  • a sixth aspect of this invention provides a further relative configuration of tapering and non-tapering bristle filaments.
  • a toothbrush head having a bristle surface from which tufts comprising plural bristles extend in a bristle direction, the tufts being disposed in a pattern on the bristle surface comprising a relatively inner cluster of plural tufts each of which contains relatively longer bristles which taper from their lower end toward their upper end, and plural relatively outer tufts of relatively shorter bristles .
  • Tufts in the relatively inner cluster may consist entirely of the relatively longer bristles which taper.
  • the plural relatively outer tufts may be disposed as outer perimeter tufts along two or more outer sides of the pattern of tufts.
  • the plural relatively outer tufts may be disposed as the outer tufts along two widthways opposite sides of the tuft pattern.
  • the outer tufts may be disposed as a ring of perimeter tufts around all sides of the relatively inner tufts.
  • the "tip end" the upper ends of the outer tufts may lie in a surface, e.g. a plane, that increase in its distance from the bristle surface with longitudinal distance away from the handle.
  • a cluster of the outer tufts e.g. a polygon of the outer tufts with their upper ends in such a surface.
  • the plural relatively outer tufts may comprise bristles which are of uniform no-tapering cross section along their lower-upper length.
  • the plural relatively outer tufts may consist entirely of tufts which consist of bristles which are of uniform cross section along their lower-upper length.
  • the difference in the length between the relatively longer bristles and the relatively shorter bristles to which they respectively extend fro the bristle face may be 2 - 7 mm, typically 2-4 mm. Typically the shorter outer tufts may be 9-11 mm long. All of the bristle filaments on the toothbrush head of this fifth aspect of the invention may be made of polyamide, e.g. Nylon, particularly the material TynexTM.
  • the handle and other parts of a toothbrush provided with the head of this invention may be otherwise conventional, and may be made of conventional materials such as the known polypropylene materials used for toothbrushes.
  • the toothbrush head may be provided integrally attached to a toothbrush handle e.g. by an intermediate integral neck, or may be replaceably attachable to the toothbrush handle.
  • the toothbrush head of this invention may be provided either for a manual or a powered toothbrush.
  • the toothbrush head of this invention may be made by a process in which the shorter bristles and longer bristles in a non-tapered state are inserted into tuft socket holes in the tooth brush head with the upper ends of the longer bristles extending above the upper ends of the shorter bristles, and the upper ends of the longer bristles are mechanically abraded into a tapered shape. Machines able to do such mechanical abrasion are known in the toothbrush manufacturing art.
  • bristle filaments may be purchased in an already tapered form. There are two main types of such commercially available tapering bristles.
  • Double ended bristle filaments are tapered at both ends and are normally mounted in a toothbrush bristle surface by folding them in the middle into a "U” shape and setting the folded middle region of the "U” shape in a socket hole in the bristle surface using a conventional "anchor".
  • the tapering and non-tapering bristle filaments may comprise such double- ended filaments, conventionally folded in a "U” shape with the bend of the "U” inserted into the socket hole and retained therein by a conventional metal anchor. In such a construction each length of "U” shaped filament provides two bristles extending from the bristle surface.
  • Single ended bristle filaments are tapered at only one end and are normally mounted in a toothbrush bristle surface by folding them close to the non-tapered end into a "J" shape and setting the folded end region of the "J" shape in a socket hole in the bristle surface using a conventional "anchor".
  • the bristle tufts of the toothbrush head of this invention may be mounted in the bristle surface using the known “anchorless” or “inmould” process in which the parts of the bristles to be set in the head are enclosed within an injection mould and the plastics material of the head in injected into the mould to embed the bristle filaments in the head.
  • the tapering tufts may be mounted in the toothbrush head of this invention in these conventional ways.
  • such single ended filaments are preferred as providing a preferred bristle density in the longer tufts.
  • Fig. 1 a perspective view of a toothbrush head of this invention.
  • Fig. 2 a sectional view of part of a toothbrush head of this invention.
  • Fig. 3 a cross sectional view through a bristle tuft of the head of Fig. 2 cut at the line A-A of Fig. 2 looking in the direction of the arrow.
  • Fig. 4 a side view of another toothbrush head of this invention.
  • Fig. 5 a side view of another toothbrush head of this invention.
  • Fig. 6 a plan view of the bristle face of the toothbrush head of Fig. 5.
  • a toothbrush head 10 overall is shown, having a bristle surface 11 from which tufts 12 (generally) comprising plural bristle filaments extend in a bristle direction 'B' generally perpendicular to the bristle surface.
  • the bristle filaments are made of the Nylon material TynexTM.
  • the lower end of each of the tufts 12 is adjacent to the bristle surface; the opposite upper end is distant from the bristle surface.
  • Each tuft 12 comprises shorter bristles 13 having a cross section which does not taper from their lower end toward their upper end and longer bristles 14 which taper from their lower end toward their upper end.
  • the longer bristles 14 taper in a generally conical shape toward their upper end, the taper of the longer bristles 14 commencing above the upper ends of the shorter bristles 13.
  • the length "d" indicated in Fig. 2 by which the length of the longer bristles 14 extends above the upper ends of the shorter bristles 13 is ca. 6mm.
  • the length to which the shorter bristles 13 extend from the bristle surface is ca. 9 mm and the length to which the longer bristles 14 extend from the bristle surface is ca. 13 mm.
  • the shorter bristle filaments 13, and the longer bristle filaments 14 over their length below the upper ends of the shorter bristles are circular in cross section, 0.15 - 0.20 mm diameter, a typical standard dimension for toothbrush bristle filaments.
  • Each of the tufts 12 is mounted in a respective tuft socket 15 having a minimum dimension perpendicular to the length direction of the bristles in the range 1.7 - 2.4 mm.
  • the total depth of the socket holes 15 is 3.6 mm, being cylindrical to a depth of 3.3mm and shallow conical below that. This is a standard depth and profile.
  • Each tuft 12 comprises double ended bristle filaments folded over into a "U" shape, with the fold of the "U” inserted into the tuft socket 15 and is fixed in place in the socket hole 15 by a metal “anchor” 16 as conventionally used in toothbrush construction. In this construction each bristle filament folded into such a "U” shape consequently provides two bristle filaments 13, 14 extending from the bristle surface 11.
  • Each of the tufts 12 contain 20 - 30 shorter bristle filaments and 2 - 12 longer filaments extending from the bristle surface 11.
  • the longer bristles 14 are disposed about the central upper-lower axis of the tuft 12, e.g. randomly disposed or as shown in Fig. 3 disposed in a central area predominantly of longer bristles 14 surrounded by an outer sheath of the shorter bristles 13.
  • the toothbrush head 10 of this invention is integrally formed with a neck 17 by which it is integrally connected to a grip handle (not shown). Between the neck 17 and the head 10 is a flexible link 18 of known construction comprising a thinned region of the neck 17 surrounded by an elastomer sphere.
  • TM toothbrush herein “toothbrush A”
  • toothbrush “B” both of medium texture bristles
  • All test toothbrushes were provided by GlaxoSmithKline Consumer Healthcare GmbH & Co. KG, Buehl, Germany.
  • the tooth brushing technique involved independent evaluations of each toothbrush in a vertical and horizontal brushing motion, tooth shapes simulating anterior and posterior teeth and a brushing weight of 250 g.
  • the brushing apparatus was set to brush 15 seconds at two strokes per second with a 50-mm stroke.
  • the maximum width of the artificial plaque removed (Interproximal Access Efficacy, IAE) was recorded in cm using vernier calipers.
  • the same examiner performed all evaluations.
  • the analysis of variance (ANOVA) was performed on the mean scores for each of the toothbrush products. Significant differences between the toothbrushes were identified using two-sample t-tests.
  • a primary method used in the laboratory assesses the ability of toothbrush bristles to penetrate between simulated teeth and remove artificial plaque, i.e. interproximal access efficacy (IAE), during the tooth brushing procedure. Both vertical and horizontal brushing motions are evaluated on simulated anterior and posterior tooth shapes. The results are then combined to determine overall efficacy of the toothbrush products evaluated. Overall efficacy in the IAE assay has been correlated with clinical plaque removal. The purpose of this study was to evaluate the test toothbrush and toothbrush A and B for efficacy in the IAE procedure.
  • IAE interproximal access efficacy
  • Interproximal access efficacy on anterior or posterior shaped teeth with horizontal brushing is shown in Table 1 below.
  • the mean IAE is significantly (p ⁇ 0.001) higher for the Test Toothbrush than for toothbrushes A or B.
  • the Test toothbrush was significantly superior (p ⁇ 0.001) to toothbrushes A and B.
  • the Test toothbrush is predicted to be more effective for clinical interproximal plaque removal than toothbrushes A and B.
  • the Gingival Margin Cleaning method utilizes wet plaque-covered pressure-sensitive paper placed over simulated posterior teeth, to compare toothbrush products for their ability to remove artificial plaque at the junction of simulated gingival tissues.
  • the second method utilizes an artificial plaque-covered pressure-sensitive substrate to evaluate the ability of toothbrush bristles to penetrate below simulated gingival tissues around posterior tooth shapes and to remove artificial plaque under wet brushing conditions. The maximum depth of the plaque deposit removed is defined as subgingival access efficacy (SAE).
  • the products tested in this assay were the Test toothbrush, and toothbrushes A and B as identified above. Six products from each group were tested four times in each individual assay for a total of 24 evaluations.
  • the laboratory equipment was fabricated to the design of Nygaard-Ostby, Edvardsen and Spydevold.
  • Simulated gingivae were prepared from self-curing dental acrylic. The marginal anatomy was developed using dental textbook guidelines. The space between the acrylic gingivae and the tooth shapes was 0.2mm.
  • the brushing technique was a horizontal brushing motion, simulated posterior teeth and an applied brushing weight of 500 g. Gingival Margin Cleaning.
  • the tooth brushing technique involved independent evaluations of each toothbrush in a horizontal brushing motion, tooth shapes simulating posterior teeth and a brushing weight of 50Og.
  • the toothbrush to be tested was aligned with the papillae of the gingival margin and the brushing apparatus was set to brush for 60 seconds at two strokes per second with a 15mm stroke.
  • the gingival margin For cleaning at the gingival margin (GMC), the length of the artificial plaque deposit removed was recorded at the junction of the simulated gingivae and pressure-sensitive paper. Readings were measured in mm with 3x magnification by one investigator. The data were analyzed using t-tests for statistical significance between the three groups, assuming unequal variances. Subgingival Access.
  • Each toothbrush to be tested was aligned with the papillae of the gingival margin, and the brushing apparatus was set to brush for 30 seconds at two strokes per second with a 15 mm stroke length.
  • the maximum depth of the plaque deposit removed (SAE) was recorded on an artificial plaque-covered substrate placed under the simulated gingivae and around the posterior-shaped teeth. Readings were measured in millimeter units with 3x magnification by one investigator. Descriptive statistics (mean and standard deviation) were calculated for the toothbrushes tested. A comparison of mean SAE was conducted using two-sample t-tests assuming unequal variances. Results
  • Test toothbrush was found to be statistically superior (p ⁇ 0.001) compared to Toothbrushes A and B in GMC and SAE as shown in Tables 4 and 5 below.
  • Table 4
  • FIG. 4 another toothbrush head 20 overall is shown, having a bristle surface 21 from which tufts 22 (generally) extend in a bristle direction "B".
  • the head 20 is integrally extended longitudinally as a neck region 23 linking the head to a grip handle 24.
  • the head 20, neck 23 and handle 24 are made of a plastics material with a rubbery grip pad 25.
  • the toothbrush shown in Figs 4, 5 and 6 is a manual toothbrush.
  • the tufts 22 are disposed in a pattern comprising a relatively inner cluster of plural tufts 26 each of which contains relatively longer bristles which taper from their lower end toward their upper end, and plural relatively outer tufts of relatively shorter bristles 27.
  • the tufts 26 consist entirely of relatively longer bristles which taper.
  • the plural relatively outer tufts 27 are disposed as an outer perimeter ring of tufts around all sides of the relatively inner tufts 26.
  • the plural relatively outer tufts 27 consist entirely of tufts which consist of bristles which are of uniform cross section along their lower-upper length.
  • the shorter outer tufts 27 are ca. 10 mm long, and the longer inner tufts 26 are ca. 13mm long.
  • the bristle filaments of the tufts 26, 27 are made of the polyamide material Nylon, typically that sold under the name TynexTM, and are typically 0.1 - 0.25 mm in diameter.
  • the longer tapered bristle filaments 26 are single ended tapered filaments.
  • Fig. 5 shows a toothbrush head in which at the end of the tuft pattern furthest from the toothbrush handle 24, being the "tip end” the upper ends of the outer tufts 28 lie in a plane, that increases in its distance from the bristle surface 21 with longitudinal distance away from the handle 24. These tufts 28 are disposed in a polygon of the outer tufts 28.

Landscapes

  • Physics & Mathematics (AREA)
  • Geometry (AREA)
  • Brushes (AREA)

Abstract

L'invention concerne des têtes de brosse à dents dont les touffes de soie sont composées de soies effilées plus longues et de soies non effilées plus courtes. Dans des modes de réalisation respectifs, les têtes de brosse à dents comprennent des touffes composées à la fois de soies effilées et de soies non effilées ainsi qu'un anneau externe de touffes de soies non effilées situé autour d'une région interne de touffes de soies effilées plus longues.
EP08774385A 2007-06-28 2008-06-26 Brosse à dents à longues soies effilées et courtes soies non effilées Withdrawn EP2164362A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0712646A GB0712646D0 (en) 2007-06-28 2007-06-28 Toothbrush
GB0712642A GB0712642D0 (en) 2007-06-28 2007-06-28 Toothbrush
PCT/EP2008/058213 WO2009000903A1 (fr) 2007-06-28 2008-06-26 Brosse à dents à longues soies effilées et courtes soies non effilées

Publications (1)

Publication Number Publication Date
EP2164362A1 true EP2164362A1 (fr) 2010-03-24

Family

ID=39760875

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08774385A Withdrawn EP2164362A1 (fr) 2007-06-28 2008-06-26 Brosse à dents à longues soies effilées et courtes soies non effilées

Country Status (13)

Country Link
US (2) US20100180392A1 (fr)
EP (1) EP2164362A1 (fr)
JP (1) JP5378370B2 (fr)
KR (1) KR20100042267A (fr)
CN (1) CN101686752A (fr)
AR (1) AR067350A1 (fr)
AU (1) AU2008267192A1 (fr)
BR (1) BRPI0813967A2 (fr)
CA (1) CA2690711A1 (fr)
CO (1) CO6280598A2 (fr)
MX (1) MX2009013951A (fr)
TW (1) TW200936077A (fr)
WO (1) WO2009000903A1 (fr)

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BRPI0813967A2 (pt) 2015-01-06
JP5378370B2 (ja) 2013-12-25
CO6280598A2 (es) 2011-05-20
CA2690711A1 (fr) 2008-12-31
US20090013489A1 (en) 2009-01-15
MX2009013951A (es) 2010-03-10
JP2010531181A (ja) 2010-09-24
KR20100042267A (ko) 2010-04-23
TW200936077A (en) 2009-09-01
WO2009000903A1 (fr) 2008-12-31
US20100180392A1 (en) 2010-07-22
CN101686752A (zh) 2010-03-31
AR067350A1 (es) 2009-10-07

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