EP2139883A4 - Hiv-1-proteasehemmer - Google Patents
Hiv-1-proteasehemmerInfo
- Publication number
- EP2139883A4 EP2139883A4 EP08744245A EP08744245A EP2139883A4 EP 2139883 A4 EP2139883 A4 EP 2139883A4 EP 08744245 A EP08744245 A EP 08744245A EP 08744245 A EP08744245 A EP 08744245A EP 2139883 A4 EP2139883 A4 EP 2139883A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- hiv
- protease inhibitors
- protease
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91989607P | 2007-03-23 | 2007-03-23 | |
US91981907P | 2007-03-23 | 2007-03-23 | |
US94182907P | 2007-06-04 | 2007-06-04 | |
US94178607P | 2007-06-04 | 2007-06-04 | |
PCT/US2008/058004 WO2008118849A2 (en) | 2007-03-23 | 2008-03-24 | Hiv-1 protease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2139883A2 EP2139883A2 (de) | 2010-01-06 |
EP2139883A4 true EP2139883A4 (de) | 2011-06-22 |
Family
ID=39789249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP08744245A Withdrawn EP2139883A4 (de) | 2007-03-23 | 2008-03-24 | Hiv-1-proteasehemmer |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP2139883A4 (de) |
CN (1) | CN101702908A (de) |
CA (1) | CA2681718A1 (de) |
WO (1) | WO2008118849A2 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010135424A1 (en) * | 2009-05-19 | 2010-11-25 | Glaxosmithkline Llc | Chemical compounds |
WO2011061590A1 (en) | 2009-11-17 | 2011-05-26 | Hetero Research Foundation | Novel carboxamide derivatives as hiv inhibitors |
LT3597646T (lt) | 2016-08-19 | 2023-09-25 | Gilead Sciences, Inc. | Terapiniai junginiai, naudotini živ viruso infekcijos profilaktikai ir terapiniam gydymui |
JOP20180009A1 (ar) | 2017-02-06 | 2019-01-30 | Gilead Sciences Inc | مركبات مثبط فيروس hiv |
AR112412A1 (es) | 2017-08-17 | 2019-10-23 | Gilead Sciences Inc | Formas de sal de colina de un inhibidor de la cápside del vih |
TWI687415B (zh) | 2017-08-17 | 2020-03-11 | 美商基利科學股份有限公司 | Hiv蛋白質膜抑制劑之固體形式 |
CN108220482A (zh) * | 2018-02-11 | 2018-06-29 | 广西医科大学 | 艾滋病治疗药物NRTIs耐药突变位点G73S的引物及其应用 |
US10836746B2 (en) | 2018-02-15 | 2020-11-17 | Gilead Sciences, Inc. | Therapeutic compounds |
KR20230141905A (ko) | 2018-07-16 | 2023-10-10 | 길리애드 사이언시즈, 인코포레이티드 | Hiv의 치료를 위한 캡시드 억제제 |
TWI766172B (zh) | 2018-07-30 | 2022-06-01 | 美商基利科學股份有限公司 | 抗hiv化合物 |
EP3938371A4 (de) * | 2019-01-15 | 2023-01-18 | Purdue Research Foundation | Hiv-1-proteasehemmer und verwendungen davon |
TW202208362A (zh) | 2020-06-25 | 2022-03-01 | 美商基利科學股份有限公司 | 用於治療hiv之蛋白殼抑制劑 |
US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
AU2022399845A1 (en) | 2021-12-03 | 2024-05-23 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
TW202412779A (zh) | 2021-12-03 | 2024-04-01 | 美商基利科學股份有限公司 | 用於hiv病毒感染之治療性化合物 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6319946B1 (en) * | 1999-02-12 | 2001-11-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of aspartyl protease |
WO2003097616A1 (en) * | 2002-05-17 | 2003-11-27 | Tibotec Pharmaceuticals Ltd | Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors |
US20040122000A1 (en) * | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
US20050209301A1 (en) * | 2004-03-11 | 2005-09-22 | Sequoia Pharmaceuticals | Resistance-repellent retroviral protease inhibitors |
WO2006104646A1 (en) * | 2005-03-11 | 2006-10-05 | Smithkline Beecham Corporation | Hiv protease inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5877334A (en) * | 1996-07-23 | 1999-03-02 | Abbott Laboratories | Intermediates useful in solid phase synthesis method |
AU4828199A (en) * | 1998-06-23 | 2000-01-10 | Board Of Trustees Of The University Of Illinois, The | Multi-drug resistant retroviral protease inhibitors and associated methods |
TWI286476B (en) * | 2001-12-12 | 2007-09-11 | Tibotec Pharm Ltd | Combination of cytochrome P450 dependent protease inhibitors |
ATE367394T1 (de) * | 2002-04-26 | 2007-08-15 | Gilead Sciences Inc | Anreicherung in der zelle an phosphonat analoga von hiv protease inhibitor verbindungen und die verbindungen selbst |
-
2008
- 2008-03-24 WO PCT/US2008/058004 patent/WO2008118849A2/en active Application Filing
- 2008-03-24 CA CA002681718A patent/CA2681718A1/en not_active Abandoned
- 2008-03-24 CN CN200880016701A patent/CN101702908A/zh active Pending
- 2008-03-24 EP EP08744245A patent/EP2139883A4/de not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040122000A1 (en) * | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
US6319946B1 (en) * | 1999-02-12 | 2001-11-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of aspartyl protease |
WO2003097616A1 (en) * | 2002-05-17 | 2003-11-27 | Tibotec Pharmaceuticals Ltd | Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors |
US20050209301A1 (en) * | 2004-03-11 | 2005-09-22 | Sequoia Pharmaceuticals | Resistance-repellent retroviral protease inhibitors |
WO2006104646A1 (en) * | 2005-03-11 | 2006-10-05 | Smithkline Beecham Corporation | Hiv protease inhibitors |
Non-Patent Citations (6)
Title |
---|
DOMINIQUE L N G SURLERAUX ET AL: "Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 48, no. 6, 24 March 2005 (2005-03-24), pages 1813 - 1822, XP002621636, ISSN: 0022-2623, [retrieved on 20041005], DOI: 10.1021/JM049560P * |
GHOSH A K ET AL: "Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-[(hydroxyethyl)amino]sulfonamide isostere", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 8, no. 6, 1 January 1998 (1998-01-01), pages 687 - 690, XP002156428, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(98)00098-5 * |
GHOSH A K ET AL: "STRUCTURE-BASED DESIGN OF NON-PEPTIDE HIV PROTEASE INHIBITORS", FARMACO, SOCIETA CHIMICA ITALIANA, PAVIA, IT, vol. 50, no. 1/02, 1 January 2001 (2001-01-01), pages 29 - 32, XP001057865, ISSN: 0014-827X, DOI: 10.1016/S0014-827X(01)01025-4 * |
MILLER J F ET AL: "Novel arylsulfonamides possessing sub-picomolar HIV protease activities and potent anti-HIV activity against wild-type and drug-resistant viral strains", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 14, no. 4, 23 February 2000 (2000-02-23), pages 959 - 963, XP002984326, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2003.12.008 * |
MILLER J F ET AL: "Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 15, no. 15, 1 August 2005 (2005-08-01), pages 3496 - 3500, XP004969879, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2005.05.129 * |
SURLERAUX D L N G ET AL: "Design of HIV-1 Protease Inhibitors Active on Multidrug-Resistant Virus", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 48, no. 6, 1 January 2005 (2005-01-01), pages 1965 - 1973, XP002414592, ISSN: 0022-2623, DOI: 10.1021/JM049454N * |
Also Published As
Publication number | Publication date |
---|---|
WO2008118849A2 (en) | 2008-10-02 |
CA2681718A1 (en) | 2008-10-02 |
CN101702908A (zh) | 2010-05-05 |
WO2008118849A3 (en) | 2008-12-18 |
EP2139883A2 (de) | 2010-01-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
LTC2178888I2 (lt) | Proteazomos inhibitoriai | |
EP2139883A4 (de) | Hiv-1-proteasehemmer | |
BRPI0807547A2 (pt) | Inibidores de aspartil protease hetercíclicos | |
HK1148739A1 (en) | Hcv protease inhibitors hcv | |
EP2307345A4 (de) | Nichtpeptidinhibitoren der hiv-1-protease | |
ZA201107636B (en) | Protease inhibitors | |
EP2435037A4 (de) | Hiv-proteasehemmer | |
EP2064177A4 (de) | Proteasehemmer | |
EP2134336A4 (de) | Von benzofuran stammende hiv-protease-hemmer | |
EP2313426A4 (de) | Neuartige proteasehemmer | |
EP2358692A4 (de) | Cysteinproteasehemmer | |
ZA201102179B (en) | Protease inhibitors | |
HK1140480A1 (en) | Cysteine protease inhibitors | |
GB0817425D0 (en) | Protease inhibitors | |
GB0705212D0 (en) | Protease inhibitors | |
GB0700369D0 (en) | Protease inhibitors | |
GB0712544D0 (en) | Protease inhibitors | |
GB0705213D0 (en) | Protease inhibitors | |
GB0700378D0 (en) | Protease inhibitors | |
GB0712543D0 (en) | Protease inhibitors | |
GB0712176D0 (en) | Protease inhibitors | |
IL175280A0 (en) | Retroviral protease inhibitors | |
GB0712540D0 (en) | Cysteine protease inhibitors | |
GB0703043D0 (en) | Cysteine protease inhibitors | |
GB0712541D0 (en) | Cysteine protease inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20091019 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: ALI, AKBAR Inventor name: KING, NANCY Inventor name: ANJUM, SAIMA, GHAFOOR Inventor name: NALAM, MADHAVI, NAGA, LAXMI Inventor name: TIDOR, BRUCE Inventor name: SCHIFFER, CELIA, A. Inventor name: NALIVAIKA, ELLEN Inventor name: KAIRYS, VISVALDAS Inventor name: CHELLAPPAN, SRIPRIYA Inventor name: CAO, HONG Inventor name: FERNANDES, MIGUEL, X. Inventor name: RANA, TARIQ, M. Inventor name: GILSON, MICHAEL Inventor name: PRABU, MOSES Inventor name: GARUDAMMAGARI SAI, KIRAN KUMAR, REDDY Inventor name: ALTMAN, MICHAEL, D. |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: NALIVAIKA, ELLEN Inventor name: CHELLAPPAN, SRIPRIYA Inventor name: SCHIFFER, CELIA, A. Inventor name: ANJUM, SAIMA, GHAFOOR Inventor name: CAO, HONG Inventor name: TIDOR, BRUCE Inventor name: KING, NANCY Inventor name: FERNANDES, MIGUEL, X. Inventor name: GARUDAMMAGARI SAI, KIRAN KUMAR, REDDY Inventor name: ALTMAN, MICHAEL, D. Inventor name: PRABU, MOSES Inventor name: ALI, AKBAR Inventor name: GILSON, MICHAEL Inventor name: NALAM, MADHAVI, NAGA, LAXMI Inventor name: RANA, TARIQ, M. Inventor name: KAIRYS, VISVALDAS |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: MASSACHUSETTS INSTITUTE OF TECHNOLOGY Owner name: UNIVERSITY OF MARYLAND, COLLEGE PARK Owner name: UNIVERSITY OF MASSACHUSETTS |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20110523 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20111001 |