EP2136638A4 - Modifizierte freisetzungsformulierungen von (6r)-4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazoldiamin und verwendungsverfahren - Google Patents

Modifizierte freisetzungsformulierungen von (6r)-4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazoldiamin und verwendungsverfahren

Info

Publication number
EP2136638A4
EP2136638A4 EP08743922A EP08743922A EP2136638A4 EP 2136638 A4 EP2136638 A4 EP 2136638A4 EP 08743922 A EP08743922 A EP 08743922A EP 08743922 A EP08743922 A EP 08743922A EP 2136638 A4 EP2136638 A4 EP 2136638A4
Authority
EP
European Patent Office
Prior art keywords
benzothiazole
tetrahydro
diamine
propyl
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08743922A
Other languages
English (en)
French (fr)
Other versions
EP2136638A1 (de
Inventor
Michael E Bozik
Valentin Gribkoff
Thomas Petzinger Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Knopp Neurosciences Inc
Original Assignee
Knopp Neurosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/957,157 external-priority patent/US8518926B2/en
Application filed by Knopp Neurosciences Inc filed Critical Knopp Neurosciences Inc
Publication of EP2136638A1 publication Critical patent/EP2136638A1/de
Publication of EP2136638A4 publication Critical patent/EP2136638A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
EP08743922A 2007-03-14 2008-03-14 Modifizierte freisetzungsformulierungen von (6r)-4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazoldiamin und verwendungsverfahren Withdrawn EP2136638A4 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US89483507P 2007-03-14 2007-03-14
US89482907P 2007-03-14 2007-03-14
US89479907P 2007-03-14 2007-03-14
US89481407P 2007-03-14 2007-03-14
US97904907P 2007-10-10 2007-10-10
US11/957,157 US8518926B2 (en) 2006-04-10 2007-12-14 Compositions and methods of using (R)-pramipexole
PCT/US2008/057059 WO2008113003A1 (en) 2007-03-14 2008-03-14 Modified release formulations of (6r)-4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazole-diamine and methods of using the same

Publications (2)

Publication Number Publication Date
EP2136638A1 EP2136638A1 (de) 2009-12-30
EP2136638A4 true EP2136638A4 (de) 2010-05-12

Family

ID=39760090

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08743922A Withdrawn EP2136638A4 (de) 2007-03-14 2008-03-14 Modifizierte freisetzungsformulierungen von (6r)-4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazoldiamin und verwendungsverfahren

Country Status (6)

Country Link
EP (1) EP2136638A4 (de)
JP (1) JP2010521493A (de)
CN (1) CN101677564A (de)
AU (1) AU2008224869A1 (de)
CA (1) CA2680800A1 (de)
WO (1) WO2008113003A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
PL2026803T3 (pl) 2006-05-16 2012-05-31 Knopp Neurosciences Inc Kompozycje R(+) i S(-) pramipeksolu i sposoby ich zastosowania
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
CA2681110A1 (en) 2007-03-14 2008-09-18 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
CA2734491A1 (en) 2008-08-19 2010-02-25 Knopp Neurosciences, Inc. Compositions and methods of using (r)-pramipexole
WO2010115267A1 (en) * 2009-04-09 2010-10-14 Purdue Pharma Once-daily oral ir/cr pramipexole formulation
EP2442655A4 (de) * 2009-06-19 2013-04-03 Knopp Neurosciences Inc Zusammensetzungen und verfahren zur behandlung von amyotropher lateralsklerose (als)
DK2493296T3 (en) 2009-10-30 2019-04-15 Retrotope Inc REMOVAL OF OXIDATIVE STRESS STATES WITH PUFA DERIVATIVES
EP2701695B1 (de) 2011-04-26 2019-04-03 Retrotope, Inc. Neurodegenerative erkrankungen und muskelerkrankungen mit polyungesättigten fettsäuren
EP3730135A1 (de) 2011-04-26 2020-10-28 Retrotope, Inc. Erkrankungen aufgrund gestörter energieverarbeitung und mitochondrienmangel
WO2012148930A2 (en) 2011-04-26 2012-11-01 Retrotope, Inc. Oxidative retinal diseases
ES2859753T3 (es) 2011-04-26 2021-10-04 Retrotope Inc Trastornos que implican la oxidación de PUFA
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
WO2013096870A1 (en) * 2011-12-22 2013-06-27 Knopp Neurosciences Inc Compositions and methods for treating amyotrophic lateral sclerosis
US20140045801A1 (en) * 2012-08-09 2014-02-13 Mylan Inc. Pramipexole transdermal delivery for severe headaches
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
WO2015006708A1 (en) 2013-07-12 2015-01-15 Knopp Biosciences Llc Treating elevated levels of eosinophils and/or basophils
US9642840B2 (en) 2013-08-13 2017-05-09 Knopp Biosciences, Llc Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders
AU2014306597B2 (en) 2013-08-13 2018-05-17 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
EP3858843A1 (de) 2015-11-23 2021-08-04 Retrotope, Inc. Ortsspezifische isotopische markierung von 1,4-dien-systemen
KR20200002899A (ko) 2017-04-10 2020-01-08 체이스 테라퓨틱스 코포레이션 시누클레인병변을 치료하기 위한 nk1-길항제 배합물 및 방법
US11779910B2 (en) 2020-02-21 2023-10-10 Biojiva Llc Processes for isotopic modification of polyunsaturated fatty acids and derivatives thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005011687A1 (de) * 2003-07-23 2005-02-10 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches system mit dem wirkstoff pramipexol
WO2006015943A2 (en) * 2004-08-13 2006-02-16 Boehringer Ingelheim International Gmbh Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
WO2007137071A2 (en) * 2006-05-16 2007-11-29 Knopp Neurosciences, Inc. Compositions of r(+) and s(-) pramipexole and methods of using the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060281797A1 (en) * 2001-12-11 2006-12-14 University Of Virginia Patent Foundation Neurorestoration with R(+) Pramipexole
CN1617720A (zh) * 2001-12-11 2005-05-18 弗吉尼亚大学专利基金会 普拉克索用于治疗肌萎缩性侧索硬化的用途
CA2619217A1 (en) * 2005-08-15 2007-02-22 University Of Virginia Patent Foundation Neurorestoration with r(+) pramipexole

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005011687A1 (de) * 2003-07-23 2005-02-10 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches system mit dem wirkstoff pramipexol
WO2006015943A2 (en) * 2004-08-13 2006-02-16 Boehringer Ingelheim International Gmbh Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
WO2007137071A2 (en) * 2006-05-16 2007-11-29 Knopp Neurosciences, Inc. Compositions of r(+) and s(-) pramipexole and methods of using the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2008113003A1 *

Also Published As

Publication number Publication date
EP2136638A1 (de) 2009-12-30
CA2680800A1 (en) 2008-09-18
AU2008224869A1 (en) 2008-09-18
JP2010521493A (ja) 2010-06-24
CN101677564A (zh) 2010-03-24
WO2008113003A1 (en) 2008-09-18

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