EP2114572A1 - Packaging tube for a pre-determined volume of a biological substance to be stored at a low temperature and system including same - Google Patents

Packaging tube for a pre-determined volume of a biological substance to be stored at a low temperature and system including same

Info

Publication number
EP2114572A1
EP2114572A1 EP08761859A EP08761859A EP2114572A1 EP 2114572 A1 EP2114572 A1 EP 2114572A1 EP 08761859 A EP08761859 A EP 08761859A EP 08761859 A EP08761859 A EP 08761859A EP 2114572 A1 EP2114572 A1 EP 2114572A1
Authority
EP
European Patent Office
Prior art keywords
tube
tube according
annular
receiving portion
biological substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08761859A
Other languages
German (de)
French (fr)
Other versions
EP2114572B1 (en
Inventor
Francis Lesieur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cryo Bio System SAS
Original Assignee
Cryo Bio System SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cryo Bio System SAS filed Critical Cryo Bio System SAS
Publication of EP2114572A1 publication Critical patent/EP2114572A1/en
Application granted granted Critical
Publication of EP2114572B1 publication Critical patent/EP2114572B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above

Definitions

  • Tube for conditioning a predetermined volume of biological substance to be kept at low temperature and system comprising same
  • the present invention relates to the packaging of biological substances to be kept at low temperature.
  • Biological substance conditioning tubes are already known to be stored at freezing temperatures (between -20 ° C. and -40 ° C.) or even at cryogenic temperatures (between -180 ° C. and -196 ° C.) such that for example, capillary tubes also called "flakes" intended to receive small volumes of biological substances.
  • the flakes initially open at both ends, are sealed at these ends by thermal welding after filling.
  • relatively rigid plastics material such as polycarbonate or polypropylene
  • Such a tube is in particular known from French Patent 2,865,190 which describes such a tube provided with a threaded portion and whose plug is of the screw type.
  • the aim of the invention is to improve the performance of such a tube, in particular with regard to safety against contaminations.
  • said predetermined volume, said tube comprising a receiving portion of said volume, characterized in that said tube also comprises an annular end portion adapted to be more easily squeezed by clamping said receiving portion and to take a flattened position where two lips are in contact with each other, said annular end portion being adapted to be secured to said lips one to the another to form a hermetic seal of said tube.
  • the plugs known in the state of the art are likely to have a sealing defect (potential source of contamination) in the face of the significant stresses they undergo due to the pressure difference between inside and outside of the tube generated by the cooling.
  • packaging tube according to the invention is thus shaped to effectively achieve hermetic sealing, although it has larger dimensions than those of flakes.
  • said annular portion has on at least part of its length a thickness smaller than the thickness of said receiving portion; the thickness of said annular portion decreases regularly in the direction from said receiving portion to said opening for introducing said volume; and or
  • said sealing is a thermal weld
  • sealing is a seal that can be activated by UV. Sealing by welding, by permanent bonding, or by any other means requiring cutting to access the contents of the tube thus ensures in a simple way the inviolability of the contents of the tube.
  • said tube also comprises at least one localized sampling zone that is more easily perforable than its environment
  • said receiving portion has, on the opposite side to said annular end portion, a housing for receiving an identification element of said substance; said housing is occupied by a resin adapted to retain said identification element;
  • said receiving portion comprises an identification sleeve of said biological substance
  • said sleeve has at least one viewing window of the inside of said tube;
  • said tube is made of plastics molded by two-material injection.
  • the invention also aims, in a second aspect, at a system for conditioning a predetermined volume of biological substance to be conserved at low temperature, characterized in that it comprises at least one tube as set out above and a jaw welding device. adapted to cause said annular portion to assume said flattened position and to weld said lips together to form said hermetic seal.
  • FIG. 1 is an elevational view of a packaging tube according to the invention
  • FIG. 2 is a sectional view of this tube taken along the line M-II of Figure 1;
  • FIG. 3 is an elevational sectional view of this tube taken along the line MI-III of FIG. 1;
  • - Figures 4 and 5 are two views similar to Figure 3 but taken in two transverse planes and after being fixed to the bottom of the tube RFID chip and after this tube has been sealed.
  • Figures 6 and 7 are two views similar to Figures 1 and 3 but for a second embodiment of the tube;
  • Figures 8 and 9 are two views similar to Figure 3 respectively showing a third and a fourth embodiment of the tube;
  • FIG. 10 is an elevational view of a welding device in which is arranged a plate provided with a row of tubes according to the invention; and FIG. 11 is an elevational view of this row of tubes and this plate after two tubes of this plate have been welded.
  • the conditioning tube 1 illustrated in FIGS. 1 to 3 comprises a receiving portion 2 of a biological substance and an annular end portion 3. Such a tube is intended to receive samples of large volume or relatively large size such as for example tissue samples.
  • the receiving portion 2 has a tubular portion 9 and a sleeve 4 partially covering the tubular portion 9.
  • the portions 3 and 9 are made of Surlyn ® low density polyethylene and the sleeve 4 of SEBS Santoprene ® .
  • Portions 3 and 9 with the sleeve 4 are made of plastics molded by two-material injection.
  • the tube 1 has an opening 8 at the edge of the annular portion 3 while it is closed near the opposite end by a transverse bottom wall 5.
  • This wall 5 is slightly set back from the end opposite the opening 8, so that this recessed wall delimits with the rest of the receiving portion 2, on the side of the portion 3, a receiving housing 6 of the biological substance and, on the other side, a housing 7, which as will be seen below is adapted to receive an identification element of the biological substance.
  • the annular end portion 3 is a tubular portion of smaller thickness than that of the receiving portion 2 so that the tube has at the junction of the portion 2 and the portion 3, a shoulder surface 12.
  • the sleeve 4 is embedded in the portion 9 so that the receiving portion 2 (the sleeve 4 and the portion 9) has a constant thickness (in the portions of the portion 9 covered or not by the sleeve 4) greater than that of the annular portion 3.
  • This sleeve has two rings 13 and 14 connected to one another by two strips 15 and 16 so that this sleeve has two windows 17 and 18 for viewing the contents of the tube 1.
  • the tube 1 has a height of 48 mm, for an internal diameter of 9.8 mm.
  • the sleeve 4 has a thickness of 0.3 mm.
  • the receiving portion 2 has a wall thickness equal to 1.0 mm (1 mm Surlyn ® for the portion 9 in the areas not covered by the sleeve and 0.7 mm Surlyn ® for the portion 9 which s' adds 0.3 mm of Santoprene ® for the sleeve 4 in the areas of the portion 9 covered by the sleeve) while the annular end portion 3 has a wall of thickness equal to 0.6 mm.
  • the dimensions of the tube 1 are chosen according to market standards so that this tube is in particular adapted to be placed in the conventional boxes for storing screw-type packaging tubes.
  • Two other conventional height values for these tubes are 70 and 92 mm.
  • the housing 7 of the tube 1 is designed to receive an identification element 21 (shown only in FIGS. 4 and 5) of the biological substance such as an RFID chip or else a mono or two-dimensional bar code (also called Datamatrix).
  • the identification element 21 is held in position in this housing by a transparent resin 22 cast in this housing to freeze the position of this identification element. It is also possible to stick a label (not shown) provided with a flexible chip on this tube.
  • the conditioning tube 1 is associated with a welding machine 24 illustrated in FIGS. 10 and 11.
  • This machine comprises a frame 25, a mobile welding module 26, and a movable plate 27.
  • the module 26 comprises two jaws 28 movable and adapted to perform reciprocating movements coordinated with the transverse displacement of the plate 27 carrying the filled tubes 1 so as to crush by pinching the annular portion 3 of each of the tubes 1.
  • the module 26 is adjustable along the frame 25 by means of the wheels 29.
  • the tubes previously filled with biological substance (using a pipette for example), are arranged in a row on the plate 27 and this plate is disposed in the welding machine 24 on a mechanism (not shown) adapted to translate the tray in the direction of alignment of the tubes.
  • the plate is then moved so that the first tube of the row is disposed between the heating jaws 28.
  • the welding machine 24 is then controlled to cause the heating jaws 28 to move so that they come closer to one another. another in the direction of the portion 3 of the tube 1 so as to crush by pressing this annular portion 3 of the tube so that the portion thus crushed takes a flattened position forming two lips 30 brought into contact with one another.
  • the crushing of the annular portion 3 causes a deformation of this portion under the weld zone and possibly a slight deformation (not shown) of the receiving portion 2 (although the wall of this portion is thicker and therefore less easily deformable ).
  • the crushing of the portion 3 causes a slight reflux of material so that the weld 31 extends slightly beyond the initial contour of the portion 3 ( Figure 4).
  • the wall of the portion 3 being of small thickness this reflux is limited, this reduced thickness also ensuring a rapid warming and uniform welding lips.
  • Such a weld would be particularly difficult to form on unconformed tubes such as the tubes according to the invention and the thickness of the walls in the weld zone is too large, such walls when they come together forming at the ends of the beads relatively difficult to crush against each other and thus adversely affect the quality of the weld especially in terms of sealing.
  • These tubes can then be stored for example in a conventional storage box.
  • the welds 31 being arranged offset relative to each other so that two neighboring tubes are not hindered by their respective weld.
  • the operator cuts the tube in a zone of the annular portion 3 located under the weld 31, for example using a hot wire, a laser or some other accessory (sterile scissors, a scalpel, or a tube cutter for example) in order to separate the portion of the tube having the weld 31 of the rest of the tube and thus have access to the biological substance.
  • a hot wire a laser or some other accessory (sterile scissors, a scalpel, or a tube cutter for example) in order to separate the portion of the tube having the weld 31 of the rest of the tube and thus have access to the biological substance.
  • the cutting of the annular portion 3 is facilitated by the fact that the latter has a reduced thickness which makes it not only more easily deformable and weldable, but also easier to cut than the rest of the tube.
  • the tube 101 is similar to the tube 1 except that it has no sleeve 4 and that it has in the receiving portion 102, at the edge of the annular portion 103, a sampling zone 119 of the same thickness as the annular portion 103 and which is thus made more easily perforable than its immediate environment (here portion 102).
  • This zone thus makes it possible to easily take the liquid by the tip of a syringe introduced into the tube through this zone.
  • FIG. 1 Another embodiment of the tube is shown in FIG. 1
  • the same references have been used but the number 200 has been added.
  • the receiving portion 202 and the annular portion 203 are no longer distinct, the shoulder 12 having disappeared, the thickness of the tube decreasing regularly in the direction from the bottom wall 205 towards the opening 208.
  • the end portion 203 thus has a relatively small average thickness so that this portion is made more easily deformable, weldable and cuttable than the rest of the tube.
  • FIG. 1 Another embodiment of the tube is shown in FIG. 1
  • the annular end portion 303 has at the junction with the receiving portion 302, a groove 310 for locally reducing the thickness of this portion, the surface 311 of the portion 303 located at the bottom of this portion. groove constituting a sampling zone or a weakening zone that is even more easily perforable and cut-off than the rest of the annular portion 303.
  • such a groove is formed in the annular portion 103 or 203 .
  • the annular portion 103 or 303 has a thickness that decreases regularly in the direction from the receiving portion 102 or 302 to the introduction opening 108 or 308.
  • the weld formed in the annular end portion has a particular pattern adapted to identify which type of machine has made it possible to produce this weld so as to reinforce the inviolability character. of the tube.
  • the bottom of the receiving portion is tapered to facilitate the recovery of the liquid.
  • the sealing of the lips of the tube is obtained not with the aid of a thermal welding but by activation of an adhesive (sensitive to UV for example).
  • an adhesive sensitive to UV for example

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Packging For Living Organisms, Food Or Medicinal Products That Are Sensitive To Environmental Conditiond (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Lining Or Joining Of Plastics Or The Like (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)

Abstract

The invention relates to a packaging tube for a pre-determined volume of a biological substance to be stored at a low temperature and to a system including same. The inventive packaging tube comprises a portion (2) for receiving the volume and an annular end portion (3) designed to be more easily crushed by pinching than the receiving portion (2) and to adopt a flattened position in which two lips (30) are in contact with one another. In addition, the annular end portion (3) is designed such that the lips (30) are secured to one another in order to form a seal (31) on the tube. The system includes at least one such tube and a jaw welding device designed to move the annular portion (3) into the flattened position and to weld the lips (30) to one another in order to form the seal (31).

Description

Tube de conditionnement d'un volume prédéterminé de substance biologique à conserver à basse température et système le comportant Tube for conditioning a predetermined volume of biological substance to be kept at low temperature and system comprising same
La présente invention concerne le conditionnement des substances biologiques à conserver à basse température.The present invention relates to the packaging of biological substances to be kept at low temperature.
On connaît déjà des tubes de conditionnement de substances biologiques à conserver à des températures de congélation (entre -200C et - 400C) ou bien encore à des températures cryogéniques (entre -1800C et - 1960C) tels que par exemple des tubes capillaires également appelés « paillettes » destinés à recevoir de faibles volumes de substances biologiques. Les paillettes, initialement ouvertes aux deux extrémités, sont scellées à ces extrémités par soudure thermique après remplissage.Biological substance conditioning tubes are already known to be stored at freezing temperatures (between -20 ° C. and -40 ° C.) or even at cryogenic temperatures (between -180 ° C. and -196 ° C.) such that for example, capillary tubes also called "flakes" intended to receive small volumes of biological substances. The flakes, initially open at both ends, are sealed at these ends by thermal welding after filling.
On connaît également, lorsque l'on ne peut pas utiliser de paillettes, par exemple pour des volumes de substances biologiques plus importants ou pour des échantillons tissulaires de plus grandes dimensions que le diamètre interne d'une paillette, des tubes de diamètre interne au moins égal à 6 mm, en matière plastique relativement rigide (telle que du polycarbonate ou du polypropylène), fermés à une extrémité et ouverts à l'extrémité opposée, et présentant une portion de réception de la substance biologique ainsi qu'une portion d'extrémité adaptée à coopérer avec un bouchon.It is also known, when it is not possible to use flakes, for example for larger volumes of biological substances or for tissue samples of larger dimensions than the internal diameter of a flake, tubes of at least internal diameter equal to 6 mm, of relatively rigid plastics material (such as polycarbonate or polypropylene), closed at one end and open at the opposite end, and having a receiving portion of the biological substance and an end portion adapted to cooperate with a plug.
Un tel tube est en particulier connu par le brevet français 2 865 190 qui décrit un tel tube muni d'une portion filetée et dont le bouchon est du type à vis. L'invention vise à améliorer les performances d'un tel tube notamment en matière de sécurité contre les contaminations.Such a tube is in particular known from French Patent 2,865,190 which describes such a tube provided with a threaded portion and whose plug is of the screw type. The aim of the invention is to improve the performance of such a tube, in particular with regard to safety against contaminations.
Elle propose à cet effet, un tube de conditionnement d'un volume prédéterminé de substance biologique à conserver à basse température, de diamètre interne au moins égal à 6 mm, fermé à une extrémité et présentant une ouverture à l'extrémité opposée pour y introduire ledit volume prédéterminé, ledit tube comportant une portion de réception dudit volume, caractérisé en ce que ledit tube comporte également une portion annulaire d'extrémité adaptée à être plus facilement écrasée par pincement que ladite portion de réception et à prendre une position aplatie où deux lèvres sont en contact l'une de l'autre, ladite portion annulaire d'extrémité étant adaptée à ce que soient assujetties lesdites lèvres l'une à l'autre pour former un scellement hermétique dudit tube. La présence d'une portion annulaire d'extrémité plus facilement déformable prévue pour le scellement par écrasement de cette portion, par exemple par soudure, permet d'obtenir dans de bonnes conditions une fermeture parfaitement hermétique du tube tout en conservant pour la portion de réception de ce tube une tenue mécanique satisfaisante. Le caractère parfaitement hermétique de la fermeture que permet d'obtenir le tube selon l'invention offre ainsi une sécurité totale notamment dans le cas du stockage à températures cryogéniques.It proposes for this purpose, a conditioning tube of a predetermined volume of biological substance to be kept at low temperature, of internal diameter at least equal to 6 mm, closed at one end and having an opening at the opposite end to introduce it. said predetermined volume, said tube comprising a receiving portion of said volume, characterized in that said tube also comprises an annular end portion adapted to be more easily squeezed by clamping said receiving portion and to take a flattened position where two lips are in contact with each other, said annular end portion being adapted to be secured to said lips one to the another to form a hermetic seal of said tube. The presence of a more easily deformable annular end portion intended for the crimping of this portion, for example by welding, makes it possible to obtain, under good conditions, a perfectly hermetic closure of the tube while retaining for the receiving portion of this tube a satisfactory mechanical behavior. The perfectly hermetic nature of the closure that allows to obtain the tube according to the invention thus offers total security especially in the case of storage at cryogenic temperatures.
On notera à cet égard que les bouchons connus dans l'état de la technique sont susceptibles de présenter un défaut d'étanchéité (potentielle source de contaminations) face aux contraintes importantes qu'ils subissent du fait de la différence de pression entre intérieur et extérieur du tube générée par le refroidissement.It should be noted in this regard that the plugs known in the state of the art are likely to have a sealing defect (potential source of contamination) in the face of the significant stresses they undergo due to the pressure difference between inside and outside of the tube generated by the cooling.
On remarquera que le tube de conditionnement selon l'invention est ainsi conformé pour réaliser efficacement un scellement hermétique et ce bien qu'il présente des dimensions plus importantes que celles des paillettes.It will be noted that the packaging tube according to the invention is thus shaped to effectively achieve hermetic sealing, although it has larger dimensions than those of flakes.
Selon des caractéristiques préférées, pour des raisons de simplicité d'utilisation, de commodité et d'économie de mise en œuvre :According to preferred features, for reasons of simplicity of use, convenience and economy of implementation:
- ladite portion annulaire présente sur au moins une partie de sa longueur une épaisseur plus faible que l'épaisseur de ladite portion de réception ; - l'épaisseur de ladite portion annulaire décroît régulièrement dans la direction qui va de ladite portion de réception à ladite ouverture d'introduction dudit volume ; et/ousaid annular portion has on at least part of its length a thickness smaller than the thickness of said receiving portion; the thickness of said annular portion decreases regularly in the direction from said receiving portion to said opening for introducing said volume; and or
- dans ladite portion annulaire est ménagée une gorge annulaire. Selon encore d'autres caractéristiques préférées, pour les mêmes raisons qu'exposées ci-dessus :- In said annular portion is formed an annular groove. According to still other preferred features, for the same reasons as explained above:
- ledit scellement est une soudure thermique ; ousaid sealing is a thermal weld; or
- ledit scellement est un scellement par colle activable par UV. Le scellement par soudure, par collage permanent, ou par tout autre moyen nécessitant une découpe pour accéder au contenu du tube garantit ainsi de façon simple l'inviolabilité du contenu du tube.said sealing is a seal that can be activated by UV. Sealing by welding, by permanent bonding, or by any other means requiring cutting to access the contents of the tube thus ensures in a simple way the inviolability of the contents of the tube.
Selon encore d'autres caractéristiques préférées : - ledit tube comporte également au moins une zone localisée de prélèvement plus facilement perforable que son environnement ;According to still other preferred features: said tube also comprises at least one localized sampling zone that is more easily perforable than its environment;
- ladite portion de réception présente, du coté opposé à ladite portion annulaire d'extrémité, un logement d'accueil d'un élément d'identification de ladite substance ; - ledit logement est occupé par une résine adaptée à retenir ledit élément d'identification ;said receiving portion has, on the opposite side to said annular end portion, a housing for receiving an identification element of said substance; said housing is occupied by a resin adapted to retain said identification element;
- ladite portion de réception comporte un manchon d'identification de ladite substance biologique ;said receiving portion comprises an identification sleeve of said biological substance;
- ledit manchon présente au moins une fenêtre de visualisation de l'intérieur dudit tube ; et/ousaid sleeve has at least one viewing window of the inside of said tube; and or
- ledit tube est en matières plastiques moulées par injection bimatière.said tube is made of plastics molded by two-material injection.
L'invention vise également sous un deuxième aspect un système pour conditionner un volume prédéterminé de substance biologique à conserver à basse température, caractérisé en ce qu'il comporte au moins un tube tel qu'exposé ci-dessus et un dispositif de soudure à mâchoires adapté à faire prendre à ladite portion annulaire ladite position aplatie et à souder lesdites lèvres l'une à l'autre pour former ledit scellement hermétique.The invention also aims, in a second aspect, at a system for conditioning a predetermined volume of biological substance to be conserved at low temperature, characterized in that it comprises at least one tube as set out above and a jaw welding device. adapted to cause said annular portion to assume said flattened position and to weld said lips together to form said hermetic seal.
L'exposé de l'invention sera maintenant poursuivi par la description détaillée d'un exemple de réalisation, donnée ci-après à titre illustratif et non limitatif, en référence aux dessins annexés. Sur ceux-ci :The presentation of the invention will now be continued by the detailed description of an exemplary embodiment, given below by way of illustration and not limitation, with reference to the accompanying drawings. On these:
- la figure 1 est une vue en élévation d'un tube de conditionnement conforme à l'invention ;- Figure 1 is an elevational view of a packaging tube according to the invention;
- la figure 2 est une vue en plan-coupe de ce tube prise selon la ligne M-Il de la figure 1 ;- Figure 2 is a sectional view of this tube taken along the line M-II of Figure 1;
- la figure 3 est une vue en élévation-coupe de ce tube prise selon la ligne MI-III de la figure 1 ; - les figures 4 et 5 sont deux vues similaires à la figure 3 mais prises selon deux plans transversaux et après qu'ait été fixé au fond du tube une puce RFID et après que ce tube ait été scellé hermétiquement.FIG. 3 is an elevational sectional view of this tube taken along the line MI-III of FIG. 1; - Figures 4 and 5 are two views similar to Figure 3 but taken in two transverse planes and after being fixed to the bottom of the tube RFID chip and after this tube has been sealed.
- les figures 6 et 7 sont deux vues similaires aux figures 1 et 3 mais pour un deuxième mode de réalisation du tube ;- Figures 6 and 7 are two views similar to Figures 1 and 3 but for a second embodiment of the tube;
- les figures 8 et 9 sont deux vues similaires à la figure 3 illustrant respectivement un troisième et un quatrième mode de réalisation du tube ;- Figures 8 and 9 are two views similar to Figure 3 respectively showing a third and a fourth embodiment of the tube;
- la figure 10 est une vue en élévation d'un dispositif de soudure dans lequel est disposé un plateau muni d'une rangée de tubes selon l'invention ; et - la figure 11 est une vue en élévation de cette rangée de tubes et de ce plateau après que deux tubes de ce plateau aient été soudés.- Figure 10 is an elevational view of a welding device in which is arranged a plate provided with a row of tubes according to the invention; and FIG. 11 is an elevational view of this row of tubes and this plate after two tubes of this plate have been welded.
Le tube de conditionnement 1 illustré sur les figures 1 à 3 comporte une portion de réception 2 d'une substance biologique et une portion annulaire d'extrémité 3. Un tel tube est destiné à recevoir des échantillons de volume important ou de taille relativement importante tels que par exemple des échantillons tissulaires.The conditioning tube 1 illustrated in FIGS. 1 to 3 comprises a receiving portion 2 of a biological substance and an annular end portion 3. Such a tube is intended to receive samples of large volume or relatively large size such as for example tissue samples.
La portion de réception 2 présente une portion tubulaire 9 et un manchon 4 recouvrant partiellement la portion tubulaire 9. Les portions 3 et 9 sont en polyéthylène basse densité Surlyn® et le manchon 4 en SEBS Santoprène®.The receiving portion 2 has a tubular portion 9 and a sleeve 4 partially covering the tubular portion 9. The portions 3 and 9 are made of Surlyn ® low density polyethylene and the sleeve 4 of SEBS Santoprene ® .
Les portions 3 et 9 avec le manchon 4 sont en matières plastiques moulées par injection bimatière.Portions 3 and 9 with the sleeve 4 are made of plastics molded by two-material injection.
Le tube 1 est présente une ouverture 8 au bord de la portion annulaire 3 tandis qu'il est obturé au voisinage de l'extrémité opposée par une paroi de fond transversale 5.The tube 1 has an opening 8 at the edge of the annular portion 3 while it is closed near the opposite end by a transverse bottom wall 5.
Cette paroi 5 est légèrement en retrait de l'extrémité opposée à l'ouverture 8, de sorte que cette paroi en renfoncement délimite avec le reste de la portion de réception 2, du côté de la portion 3, un logement de réception 6 de la substance biologique et, de l'autre côté, un logement 7, qui comme on le verra ci-après est adapté à recevoir un élément d'identification de la substance biologique. La portion annulaire d'extrémité 3 est une portion tubulaire de plus faible épaisseur que celle de la portion de réception 2 de sorte que le tube présente à la jonction de la portion 2 et de la portion 3, une surface en épaulement 12. Le manchon 4 est incrusté dans la portion 9 de sorte que la portion de réception 2 (le manchon 4 et la portion 9) présente une épaisseur constante (dans les zones de la portion 9 couvertes ou non par le manchon 4) plus grande que celle de la portion annulaire 3.This wall 5 is slightly set back from the end opposite the opening 8, so that this recessed wall delimits with the rest of the receiving portion 2, on the side of the portion 3, a receiving housing 6 of the biological substance and, on the other side, a housing 7, which as will be seen below is adapted to receive an identification element of the biological substance. The annular end portion 3 is a tubular portion of smaller thickness than that of the receiving portion 2 so that the tube has at the junction of the portion 2 and the portion 3, a shoulder surface 12. The sleeve 4 is embedded in the portion 9 so that the receiving portion 2 (the sleeve 4 and the portion 9) has a constant thickness (in the portions of the portion 9 covered or not by the sleeve 4) greater than that of the annular portion 3.
Ce manchon présente deux bagues 13 et 14 reliées l'une à l'autre par deux bandeaux 15 et 16 de sorte que ce manchon présente deux fenêtres 17 et 18 de visualisation du contenu du tube 1.This sleeve has two rings 13 and 14 connected to one another by two strips 15 and 16 so that this sleeve has two windows 17 and 18 for viewing the contents of the tube 1.
Dans l'exemple illustré, le tube 1 présente une hauteur de 48 mm, pour un diamètre intérieur de 9,8 mm.In the example illustrated, the tube 1 has a height of 48 mm, for an internal diameter of 9.8 mm.
Le manchon 4 présente une épaisseur de 0,3 mm. La portion de réception 2 présente une paroi d'épaisseur égale à 1,0 mm (1 mm de Surlyn® pour la portion 9 dans les zones non recouvertes par le manchon et 0,7 mm de Surlyn® pour la portion 9 auquel s'ajoute 0,3 mm de Santoprène® pour le manchon 4 dans les zones de la portion 9 recouvertes par le manchon) tandis que la portion annulaire d'extrémité 3 présente une paroi d'épaisseur égale à 0,6 mm.The sleeve 4 has a thickness of 0.3 mm. The receiving portion 2 has a wall thickness equal to 1.0 mm (1 mm Surlyn ® for the portion 9 in the areas not covered by the sleeve and 0.7 mm Surlyn ® for the portion 9 which s' adds 0.3 mm of Santoprene ® for the sleeve 4 in the areas of the portion 9 covered by the sleeve) while the annular end portion 3 has a wall of thickness equal to 0.6 mm.
Les dimensions du tube 1 sont choisies conformément aux standards du marché de sorte que ce tube est en particulier adapté à être disposé dans les boîtes conventionnelles de stockage des tubes de conditionnement à vis.The dimensions of the tube 1 are chosen according to market standards so that this tube is in particular adapted to be placed in the conventional boxes for storing screw-type packaging tubes.
Deux autres valeurs classiques de hauteur pour ces tubes sont 70 et 92 mm.Two other conventional height values for these tubes are 70 and 92 mm.
Le logement 7 du tube 1 est conçu pour recevoir un élément d'identification 21 (représenté uniquement sur les figures 4 et 5) de la substance biologique tel qu'une puce RFID ou bien encore un code barre mono ou bi-dimensionnel (également appelé Datamatrix). L'élément d'identification 21 est maintenu en position dans ce logement par une résine transparente 22 coulée dans ce logement pour figer la position de cet élément d'identification. II est également possible de coller une étiquette (non représentée) munie d'une puce flexible sur ce tube.The housing 7 of the tube 1 is designed to receive an identification element 21 (shown only in FIGS. 4 and 5) of the biological substance such as an RFID chip or else a mono or two-dimensional bar code (also called Datamatrix). The identification element 21 is held in position in this housing by a transparent resin 22 cast in this housing to freeze the position of this identification element. It is also possible to stick a label (not shown) provided with a flexible chip on this tube.
Dans le cas où il est nécessaire de maintenir la stérilité de l'intérieur du tube avant remplissage, celui-ci est livré dans une boîte à tubes stérilisée par rayonnement ou bien encore dans un sachet unitaire pelable.In the case where it is necessary to maintain the sterility of the inside of the tube before filling, it is delivered in a radiation sterilized tube box or even in a peelable unit bag.
Le tube de conditionnement 1 est associé à une machine à souder 24 illustrée sur les figures 10 et 11.The conditioning tube 1 is associated with a welding machine 24 illustrated in FIGS. 10 and 11.
Cette machine comporte un bâti 25, un module de soudure mobile 26, et un plateau mobile 27. Le module 26 comporte deux mâchoires 28 mobiles et adaptées à réaliser des mouvements de va-et-vient coordonnés avec le déplacement transversal du plateau 27 transportant les tubes remplis 1 de façon à venir écraser par pincement la portion annulaire 3 de chacun des tubes 1.This machine comprises a frame 25, a mobile welding module 26, and a movable plate 27. The module 26 comprises two jaws 28 movable and adapted to perform reciprocating movements coordinated with the transverse displacement of the plate 27 carrying the filled tubes 1 so as to crush by pinching the annular portion 3 of each of the tubes 1.
En fonction de la hauteur des tubes, le module 26 est ajustable le long du bâti 25 à l'aide des molettes 29.Depending on the height of the tubes, the module 26 is adjustable along the frame 25 by means of the wheels 29.
On va maintenant décrire comment est scellé hermétiquement un tube de conditionnement à l'aide des figures 4, 5, 10 et 11.We will now describe how is hermetically sealed a conditioning tube with the help of Figures 4, 5, 10 and 11.
Les tubes, préalablement remplis de substance biologique (à l'aide d'une pipette par exemple), sont disposés en rangée sur le plateau 27 et ce plateau est disposé dans la machine à souder 24 sur un mécanisme (non représenté) adapté à translater le plateau selon la direction d'alignement des tubes.The tubes, previously filled with biological substance (using a pipette for example), are arranged in a row on the plate 27 and this plate is disposed in the welding machine 24 on a mechanism (not shown) adapted to translate the tray in the direction of alignment of the tubes.
Le plateau est alors déplacé pour que le premier tube de la rangée soit disposé entre les mâchoires chauffantes 28. La machine à souder 24 est alors commandée pour entraîner le déplacement des mâchoires chauffantes 28 de sorte qu'elles se rapprochent l'une de l'autre en direction de la portion 3 du tube 1 de façon à venir écraser par pincement cette portion annulaire 3 du tube pour que la portion ainsi écrasée prenne une position aplatie en formant deux lèvres 30 mises en contact l'une de l'autre.The plate is then moved so that the first tube of the row is disposed between the heating jaws 28. The welding machine 24 is then controlled to cause the heating jaws 28 to move so that they come closer to one another. another in the direction of the portion 3 of the tube 1 so as to crush by pressing this annular portion 3 of the tube so that the portion thus crushed takes a flattened position forming two lips 30 brought into contact with one another.
Simultanément à l'écrasement, la chaleur transmise par les mâchoires chauffantes au Surlyn® de la portion 3 entraîne la formation d'une soudure hermétique 31 entre les deux lèvres 30 comme illustré sur les figures 4 et 5.Simultaneously with the crushing, the heat transmitted by the heating jaws to the Surlyn ® of the portion 3 causes the formation of a hermetic seal 31 between the two lips 30 as illustrated in Figures 4 and 5.
L'écrasement de la portion annulaire 3 entraîne une déformation de cette portion sous la zone de soudure et éventuellement une légère déformation (non illustrée) de la portion de réception 2 (bien que la paroi de cette portion soit plus épaisse et donc moins facilement déformable).The crushing of the annular portion 3 causes a deformation of this portion under the weld zone and possibly a slight deformation (not shown) of the receiving portion 2 (although the wall of this portion is thicker and therefore less easily deformable ).
L'écrasement de la portion 3 entraîne un léger reflux de matière de sorte que la soudure 31 s'étend légèrement au-delà du contour initial de la portion 3 (figure 4). La paroi de la portion 3 étant de faible épaisseur ce reflux est limité, cette épaisseur réduite assurant également une mise en température rapide et homogène des lèvres à souder.The crushing of the portion 3 causes a slight reflux of material so that the weld 31 extends slightly beyond the initial contour of the portion 3 (Figure 4). The wall of the portion 3 being of small thickness this reflux is limited, this reduced thickness also ensuring a rapid warming and uniform welding lips.
Une telle soudure serait particulièrement délicate à former sur des tubes non conformés comme les tubes selon l'invention et dont l'épaisseur des parois dans la zone de soudure est trop importante, de telles parois lorsqu'elles se rapprochent formant alors aux extrémités des bourrelets relativement difficiles à écraser l'un contre l'autre risquant de nuire ainsi à la qualité de la soudure notamment sur le plan de l'étanchéité.Such a weld would be particularly difficult to form on unconformed tubes such as the tubes according to the invention and the thickness of the walls in the weld zone is too large, such walls when they come together forming at the ends of the beads relatively difficult to crush against each other and thus adversely affect the quality of the weld especially in terms of sealing.
Après retour des mâchoires 28 dans leur position initiale, la machine 24 est alors commandée pour entraîner le déplacement du plateau de sorte que le tube suivant soit disposé à son tour entre les mâchoires 28 (figure 11).After return of the jaws 28 to their initial position, the machine 24 is then controlled to cause the displacement of the plate so that the next tube is disposed in turn between the jaws 28 (Figure 11).
Ces opérations se poursuivent ainsi jusqu'à ce que le dernier tube de la rangée du plateau 27 soit soudé.These operations continue thus until the last tube of the row of the plate 27 is welded.
Ces tubes peuvent ensuite être stockés par exemple dans une boîte de stockage conventionnelle. Les soudures 31 étant disposées décalées les unes par rapport aux autres de façon à ce que deux tubes voisins ne soient pas gênés par leur soudure respective.These tubes can then be stored for example in a conventional storage box. The welds 31 being arranged offset relative to each other so that two neighboring tubes are not hindered by their respective weld.
Pour accéder à la substance biologique, l'opérateur coupe le tube dans une zone de la portion annulaire 3 située sous la soudure 31, par exemple à l'aide d'un fil chaud, d'un laser ou d'un autre accessoire (des ciseaux stériles, un scalpel, ou encore un coupe-tube par exemple) afin de désolidariser la portion du tube présentant la soudure 31 du reste du tube et ainsi avoir accès à la substance biologique.To access the biological substance, the operator cuts the tube in a zone of the annular portion 3 located under the weld 31, for example using a hot wire, a laser or some other accessory ( sterile scissors, a scalpel, or a tube cutter for example) in order to separate the portion of the tube having the weld 31 of the rest of the tube and thus have access to the biological substance.
La découpe de la portion annulaire 3 est facilitée par le fait que celle- ci présente une épaisseur réduite qui la rend non seulement plus facilement déformable et soudable, mais également plus facilement découpable que le reste du tube.The cutting of the annular portion 3 is facilitated by the fact that the latter has a reduced thickness which makes it not only more easily deformable and weldable, but also easier to cut than the rest of the tube.
Un autre mode de réalisation du tube est représenté sur les figures 6 et 7.Another embodiment of the tube is shown in FIGS. 6 and 7.
D'une manière générale, on a employé pour les éléments similaires les mêmes références mais additionnées du nombre 100.In general, the same references have been used for similar elements but the number 100 has been added.
Le tube 101 est semblable au tube 1 si ce n'est qu'il est dépourvu de manchon 4 et qu'il présente dans la portion de réception 102, au bord de la portion annulaire 103, une zone de prélèvement 119 de même épaisseur que la portion annulaire 103 et qui est ainsi rendue plus facilement perforable que son environnement immédiat (ici la portion 102).The tube 101 is similar to the tube 1 except that it has no sleeve 4 and that it has in the receiving portion 102, at the edge of the annular portion 103, a sampling zone 119 of the same thickness as the annular portion 103 and which is thus made more easily perforable than its immediate environment (here portion 102).
Cette zone permet ainsi de prélever facilement le liquide par la pointe d'une seringue introduite dans le tube par cette zone.This zone thus makes it possible to easily take the liquid by the tip of a syringe introduced into the tube through this zone.
Il n'est alors plus nécessaire de sectionner la portion scellée du tube pour avoir accès à la substance biologique. On remarquera d'ailleurs à ce titre qu'il est également possible, dans le mode de réalisation précédent, de prélever le liquide par l'intermédiaire de la pointe d'une seringue en perçant au travers de la portion annulaire 3 qui n'est pas soudée, cependant dans le présent mode de réalisation, cette zone de prélèvement est visuellement bien identifiée et est ménagée au niveau de la portion de réception 2.It is then no longer necessary to sever the sealed portion of the tube to gain access to the biological substance. It will also be noted in this respect that it is also possible, in the preceding embodiment, to take the liquid through the tip of a syringe by piercing through the annular portion 3 which is not not welded, however in the present embodiment, this sampling zone is visually well identified and is formed at the receiving portion 2.
Dans une variante non illustrée du tube 101 , il est prévu deux ou davantage que deux zones de prélèvement 119.In a non-illustrated variant of the tube 101, there are two or more than two sampling zones 119.
Un autre mode de réalisation du tube est représenté en figure 8.Another embodiment of the tube is shown in FIG.
D'une manière générale, on a employé pour les éléments similaires au mode de réalisation des figures 1 à 5, les mêmes références mais additionnées du nombre 200. Dans ce mode de réalisation, la portion de réception 202 et la portion annulaire 203 ne sont plus distinctes, l'épaulement 12 ayant disparu, l'épaisseur du tube décroissant régulièrement dans la direction qui va de la paroi de fond 205 vers l'ouverture 208. La portion d'extrémité 203 présente ainsi une épaisseur moyenne relativement faible de sorte que cette portion est rendue plus facilement déformable, soudable et découpable que le reste du tube.In a general manner, for the elements similar to the embodiment of FIGS. 1 to 5, the same references have been used but the number 200 has been added. In this embodiment, the receiving portion 202 and the annular portion 203 are no longer distinct, the shoulder 12 having disappeared, the thickness of the tube decreasing regularly in the direction from the bottom wall 205 towards the opening 208. The end portion 203 thus has a relatively small average thickness so that this portion is made more easily deformable, weldable and cuttable than the rest of the tube.
Un autre mode de réalisation du tube est représenté en figure 9.Another embodiment of the tube is shown in FIG.
D'une manière générale, on a employé pour les éléments similaires au mode de réalisation des figures 1 à 5, les mêmes références mais additionnées du nombre 300.In a general manner, for the elements similar to the embodiment of FIGS. 1 to 5, the same references have been used but the number 300 has been added.
Dans ce mode de réalisation, la portion annulaire d'extrémité 303 présente à la jonction avec la portion de réception 302, une gorge 310 destinée à réduire localement l'épaisseur de cette portion, la surface 311 de la portion 303 située au fond de cette gorge constituant une zone de prélèvement ou une zone d'affaiblissement encore plus facilement perforable et découpable que le reste de la portion annulaire 303. Dans une variante non illustrée des tubes 101 et 201 , une telle gorge est ménagée dans la portion annulaire 103 ou 203.In this embodiment, the annular end portion 303 has at the junction with the receiving portion 302, a groove 310 for locally reducing the thickness of this portion, the surface 311 of the portion 303 located at the bottom of this portion. groove constituting a sampling zone or a weakening zone that is even more easily perforable and cut-off than the rest of the annular portion 303. In a variant (not shown) of the tubes 101 and 201, such a groove is formed in the annular portion 103 or 203 .
Dans une variante non illustrée des tubes 101 et 301 , la portion annulaire 103 ou 303 présente un épaisseur qui décroît régulièrement dans la direction qui va de la portion de réception 102 ou 302 vers l'ouverture d'introduction 108 ou 308.In a non-illustrated variant of the tubes 101 and 301, the annular portion 103 or 303 has a thickness that decreases regularly in the direction from the receiving portion 102 or 302 to the introduction opening 108 or 308.
Dans une variante non représentée des tubes 101, 201 ou 301, la soudure formée dans la portion d'extrémité annulaire, présente un motif particulier adapté à identifier quel type de machine a permis de réaliser cette soudure de façon à renforcer le caractère d'inviolabilité du tube.In a not shown variant of the tubes 101, 201 or 301, the weld formed in the annular end portion has a particular pattern adapted to identify which type of machine has made it possible to produce this weld so as to reinforce the inviolability character. of the tube.
Dans une autre variante non représentée le fond de la portion de réception est conique afin de faciliter la récupération du liquide.In another variant not shown the bottom of the receiving portion is tapered to facilitate the recovery of the liquid.
Dans une autre variante encore le scellement des lèvres du tube est obtenu non pas à l'aide d'une soudure thermique mais par activation d'une colle (sensible aux UV par exemple). De nombreuses autres variantes sont possibles en fonction des circonstances, et l'on rappelle à cet égard que l'invention ne se limite pas aux exemples décrits et représentés. In another variant, the sealing of the lips of the tube is obtained not with the aid of a thermal welding but by activation of an adhesive (sensitive to UV for example). Many other variants are possible depending on the circumstances, and it is recalled in this regard that the invention is not limited to the examples described and shown.

Claims

REVENDICATIONS
1. Tube de conditionnement d'un volume prédéterminé de substance biologique à conserver à basse température, de diamètre interne au moins égal à 6 mm, fermé à une extrémité et présentant une ouverture (8 ; 108 ; 208 ; 308) à l'extrémité opposée pour y introduire ledit volume prédéterminé, ledit tube comportant une portion de réception (2 ; 102 ; 202 ; 302) dudit volume, caractérisé en ce que ledit tube comporte également une portion annulaire d'extrémité (3 ; 103 ; 203 ; 303) adaptée à être plus facilement écrasée par pincement que ladite portion de réception (2 ; 102 ; 202 ; 302) et à prendre une position aplatie où deux lèvres (30) sont en contact l'une de l'autre, ladite portion annulaire d'extrémité (3 ; 103 ; 203 ; 303) étant adaptée à ce que soient assujetties lesdites lèvres (30) l'une à l'autre pour former un scellement hermétique (31) dudit tube. 1. A conditioning tube of a predetermined volume of biological substance to be stored at a low temperature, having an internal diameter of at least 6 mm, closed at one end and having an opening (8; 108; 208; 308) at the end. opposed to introduce said predetermined volume, said tube comprising a receiving portion (2; 102; 202; 302) of said volume, characterized in that said tube also comprises an annular end portion (3; 103; 203; 303); adapted to be more easily crushed by clamping than said receiving portion (2; 102; 202; 302) and to take a flattened position where two lips (30) are in contact with each other, said annular portion of end (3; 103; 203; 303) being adapted so that said lips (30) are secured to one another to form a hermetic seal (31) of said tube.
2. Tube selon la revendication 1 , caractérisé en ce que ladite portion annulaire (3 ; 103 ; 203 ; 303) présente sur au moins une partie de sa longueur une épaisseur plus faible que l'épaisseur de ladite portion de réception (2 ; 102 ; 202 ; 302).2. Tube according to claim 1, characterized in that said annular portion (3; 103; 203; 303) has on at least a part of its length a thickness smaller than the thickness of said receiving portion (2; 202; 302).
3. Tube selon la revendication 2, caractérisé en ce que en ce que l'épaisseur de ladite portion annulaire (203) décroît régulièrement dans la direction qui va de ladite portion de réception (202) à ladite ouverture d'introduction (208) dudit volume.3. Tube according to claim 2, characterized in that the thickness of said annular portion (203) decreases regularly in the direction from said receiving portion (202) to said insertion opening (208) of said volume.
4. Tube selon l'une quelconque des revendications 1 à 3, caractérisé en ce qu'est ménagée dans ladite portion annulaire (303) une gorge annulaire (310).4. Tube according to any one of claims 1 to 3, characterized in that is formed in said annular portion (303) an annular groove (310).
5. Tube selon l'une quelconque des revendications 1 à 4, caractérisé en ce que ledit scellement est une soudure thermique (31).5. Tube according to any one of claims 1 to 4, characterized in that said seal is a heat seal (31).
6. Tube selon l'une quelconque des revendications 1 à 4, caractérisé en ce que ledit scellement est un scellement par colle activable par UV. 6. Tube according to any one of claims 1 to 4, characterized in that said seal is a UV activatable adhesive seal.
7. Tube selon l'une quelconque des revendications 1 à 6, caractérisé en ce que ledit tube comporte également au moins une zone localisée de prélèvement (119 ; 311) plus facilement perforable que son environnement. 7. Tube according to any one of claims 1 to 6, characterized in that said tube also comprises at least one localized sampling zone (119; 311) more easily perforable than its environment.
8. Tube selon l'une quelconque des revendications 1 à 7, caractérisé en ce que ladite portion de réception (2 ; 102 ; 202 ; 302) présente, du coté opposé à ladite portion annulaire d'extrémité (3 ; 103 ; 203 ; 303), un logement d'accueil (7 ; 107 ; 207 ; 307) d'un élément d'identification (21) de ladite substance. 8. Tube according to any one of claims 1 to 7, characterized in that said receiving portion (2; 102; 202; 302) has, on the opposite side to said annular end portion (3; 103; 203; 303), a receiving housing (7; 107; 207; 307) of an identification element (21) of said substance.
9. Tube selon la revendication 8, caractérisé en ce que ledit logement9. Tube according to claim 8, characterized in that said housing
(7 ; 107 ; 207 ; 307) est occupé par une résine (22) adaptée à retenir ledit élément d'identification (21).(7; 107; 207; 307) is occupied by a resin (22) adapted to retain said identification element (21).
10. Tube selon l'une quelconque des revendications 1 à 9, caractérisé en ce que ladite portion de réception (2) comporte un manchon d'identification (4) de ladite substance biologique.10. Tube according to any one of claims 1 to 9, characterized in that said receiving portion (2) comprises an identification sleeve (4) of said biological substance.
11. Tube selon l'une quelconque des revendications 1 à 10, caractérisé en ce que ledit manchon (4) présente au moins une fenêtre (17, 18) de visualisation de l'intérieur dudit tube.11. Tube according to any one of claims 1 to 10, characterized in that said sleeve (4) has at least one window (17, 18) for viewing the interior of said tube.
12. Tube selon l'une quelconque des revendications 10 ou 11 , caractérisé en ce qu'il est en matières plastiques moulées par injection bimatière.12. Tube according to any one of claims 10 or 11, characterized in that it is made of plastics molded by bimaterial injection.
13. Système pour conditionner un volume prédéterminé de substance biologique à conserver à basse température, caractérisé en ce qu'il comporte au moins un tube selon l'une quelconque des revendications 1 à 12 et un dispositif de soudure (24) à mâchoires (28) adapté à faire prendre à ladite portion annulaire (3 ; 103 ; 203 ; 303) ladite position aplatie et à souder lesdites lèvres (30) l'une à l'autre pour former ledit scellement hermétique (31). 13. System for conditioning a predetermined volume of biological substance to be stored at low temperature, characterized in that it comprises at least one tube according to any one of claims 1 to 12 and a welding device (24) with jaws (28). ) adapted to cause said annular portion (3; 103; 203; 303) to assume said flattened position and to weld said lips (30) to one another to form said hermetic seal (31).
EP08761859.1A 2007-02-19 2008-02-08 Packaging tube for a pre-determined volume of a biological substance to be stored at a low temperature and system including same Active EP2114572B1 (en)

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FR0753346A FR2912727B1 (en) 2007-02-19 2007-02-19 PACKAGING TUBE OF A PREDETERMINED VOLUME OF BIOLOGICAL SUBSTANCE TO BE PRESERVED AT LOW TEMPERATURE AND SYSTEM COMPRISING SAME
PCT/FR2008/000158 WO2008116977A1 (en) 2007-02-19 2008-02-08 Packaging tube for a pre-determined volume of a biological substance to be stored at a low temperature and system including same

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Also Published As

Publication number Publication date
FR2912727B1 (en) 2013-07-19
MX2009008814A (en) 2009-12-14
RU2009135002A (en) 2011-03-27
WO2008116977A1 (en) 2008-10-02
FR2912727A1 (en) 2008-08-22
WO2008116977A8 (en) 2009-09-17
DK2114572T3 (en) 2021-03-01
US20100107560A1 (en) 2010-05-06
CN101678357A (en) 2010-03-24
US8266872B2 (en) 2012-09-18
CN101678357B (en) 2012-07-04
EP2114572B1 (en) 2020-12-09
RU2457032C2 (en) 2012-07-27

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