EP2108391B1 - Méthode et dispositif pour surveiller l'adduction de liquide de substitution pendant un traitement extracorporel du sang - Google Patents
Méthode et dispositif pour surveiller l'adduction de liquide de substitution pendant un traitement extracorporel du sang Download PDFInfo
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- EP2108391B1 EP2108391B1 EP09009766A EP09009766A EP2108391B1 EP 2108391 B1 EP2108391 B1 EP 2108391B1 EP 09009766 A EP09009766 A EP 09009766A EP 09009766 A EP09009766 A EP 09009766A EP 2108391 B1 EP2108391 B1 EP 2108391B1
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- Prior art keywords
- filter
- dialyser
- pump
- blood
- pressure signal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02141—Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7225—Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7253—Details of waveform analysis characterised by using transforms
- A61B5/7257—Details of waveform analysis characterised by using transforms using Fourier transforms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
- A61M1/3431—Substitution fluid path upstream of the filter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
- A61M1/3431—Substitution fluid path upstream of the filter
- A61M1/3434—Substitution fluid path upstream of the filter with pre-dilution and post-dilution
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
- A61M1/3437—Substitution fluid path downstream of the filter, e.g. post-dilution with filtrate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3455—Substitution fluids
- A61M1/3465—Substitution fluids using dialysate as substitution fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
- A61M1/361—Physical characteristics of the blood, e.g. haematocrit, urea before treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
- A61M1/3612—Physical characteristics of the blood, e.g. haematocrit, urea after treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3639—Blood pressure control, pressure transducers specially adapted therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
- A61M1/3655—Arterio-venous shunts or fistulae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
- A61M1/3656—Monitoring patency or flow at connection sites; Detecting disconnections
- A61M1/3658—Indicating the amount of purified blood recirculating in the fistula or shunt
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3355—Controlling downstream pump pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/70—General characteristics of the apparatus with testing or calibration facilities
- A61M2205/702—General characteristics of the apparatus with testing or calibration facilities automatically during use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/30—Blood pressure
Definitions
- the invention relates to a method for monitoring the supply of substitution fluid for an extracorporeal blood treatment device with an extracorporeal blood circuit, which includes a first chamber of a dialyzer or filter subdivided by a membrane into the first chamber and a second chamber, and a fluid system, which includes the second chamber of the dialyzer or filter. Moreover, the invention relates to such a device for extracorporeal blood treatment with a device for detecting the supply of substitution fluid upstream or downstream of the dialyzer or filter.
- hemodialysis In the case of chronic renal failure, various procedures for extracorporeal blood treatment and cleansing are used to remove urinary-excreted substances and to remove fluids.
- the patient's blood In hemodialysis, the patient's blood is purified outside the body in a dialyzer.
- the dialyzer has a blood chamber and a dialysis fluid chamber which are separated by a semipermeable membrane. During the treatment, the patient's blood flows through the blood chamber.
- the dialysis fluid chamber is continuously flowed through by fresh dialysis fluid.
- hemodialysis While in hemodialysis (HD) of the transport of small molecular substances through the membrane is essentially determined by the concentration differences (diffusion) between the dialysis fluid and the blood, in hemofiltration (HF) in the plasma water dissolved substances, especially higher molecular weight substances by a high liquid flow (convection) through the membrane of the dialyzer effectively away. In hemofiltration, the dialyzer acts as a filter. A combination of both methods is hemodiafiltration (HDF).
- HDF hemodiafiltration
- a portion of the serum withdrawn through the membrane is replaced by a sterile substitution fluid, which is supplied either upstream of the dialyzer or downstream of the dialyzer to the extracorporeal blood circuit.
- the supply, the substitution fluid upstream of the dialyzer is also referred to as predilution and the supply downstream of the dialyzer as postdilution.
- Devices for hemo (dia) filtration are known in which the dialysis fluid is prepared online from fresh water and concentrations and the substitution fluid is prepared online from the dialysis fluid.
- the substitution fluid is supplied to the extracorporeal blood circuit from the fluid system of the machine via a substitution fluid line.
- the substitution fluid line leads to a junction at the arterial blood line upstream of the dialyzer or filter, while in postdilution the substitution fluid line leads to a junction at the venous blood line downstream of the dialyzer.
- the substitution fluid line generally has a connector with which it can be connected either to the venous or arterial blood line. To interrupt the hydration is at the. Substitutionsfishkeitsön a clamp or the like.
- Such hemo (dia) filtration device is for example from the EP-A-0 189 561 known.
- the monitoring of blood treatment requires knowledge as to whether the substitution fluid upstream or downstream of the dialyzer or filter is being delivered to the extracorporeal blood circuit.
- pre- and post-dilution plays a role in the conductivity-based online clearance measurement (OCM), because the conductivity of the dialysis fluid downstream of the dialyzer depends on whether pre- or post-dilution occurs.
- OCM conductivity-based online clearance measurement
- the EP-A-1 348 458 A1 describes a method and apparatus for monitoring the delivery of substitution fluid to an extracorporeal blood treatment device.
- the transit time of the pressure waves of a substituate pump arranged in the substitution liquid line is measured.
- the supply of substitution liquid upstream or downstream of the dialyzer or filter is detected on the basis of the transit time measurement.
- the known method requires the use of a pressure wave generating Substituatpumpe.
- the DE 101 15 991 C1 describes a device for detecting stenoses in a tubing system.
- the document proposes to infer a stenosis (bottleneck) in the tubing system with a change in the frequency spectrum of an oscillating pressure signal propagating in the tubing system.
- the principle of operation of the known device is based on the fact that the cause of the change in the dynamic behavior of the hose line system is the compliance of the line system, ie the elastic yielding under pressure.
- the invention is based on the object to provide a method that allows the detection of pre- and post-dilution with high reliability.
- the invention is based on a measurement of the pressure in the liquid system downstream of the dialyzer or filter.
- the invention requires the use of a pressure wave generating Substituatpumpe.
- the supply of substitution liquid upstream or downstream of the dialyzer or filter is detected on the basis of the comparison of the circulating blood circulating pressure signal due to the substituate pump with a characteristic reference signal.
- the method and the device according to the invention are based on the fact that the frequency spectrum of the oscillating pressure signal is dependent on whether the pressure signal does not propagate via the dialyzer during predilution via the dialyzer or during postdilution. Also, the amplitude of the pressure pulses changes depending on pre- or post-dilution.
- the oscillating pressure signal of the substituate pump propagated in the extracorporeal blood circulation is superimposed by further pressure signals which are due, for example, to the blood pump arranged upstream of the dialyzer or filter or devices arranged in the fluid system, for example the concentrate pump, ultrafiltration pump or balancing chambers counting. Therefore, the pressure signal to be fed back to the substituate pump is obtained from the pressure signal measured in the blood circulation.
- the dialyzer or filter can also be separated from the fluid system.
- a preferred embodiment which allows detection of the supply of substitution fluid with particularly high reliability, provides as a characteristic reference signal the signal of the blood circulation pump arranged in the extracorporeal blood circulation upstream of the dialyzer or filter, which also generates oscillating pressure signals.
- This embodiment is based on the assumption that, in the case of predilution, oscillation of the pressure signals from the blood pump and the substituate pump, which propagate via the dialyzer and the tube system, differ only insignificantly from one another.
- the oscillation of the pressure signals from the substituate pump and the blood pump differ significantly, since the pressure signals of the Substituent pump does not propagate through the dialyzer. This is not only a relative, but also an absolute differentiator between pre- and post-dilution.
- a Fourier analysis of the pressure signal measured downstream of the dialyzer or filter is preferably carried out.
- the amplitudes of at least two harmonics are preferably determined from the pressure signals of the substituate pump and blood pump.
- At least one quotient of at least one higher-order harmonic and at least one lower-order harmonic of the substituate pump determines at least one first weighting factor and at least one ratio of at least one higher-order harmonic and at least one lower-order harmonic of the blood pump determines at least a second weighting factor.
- Post-dilution is then concluded when the difference between the first.
- Weighting factor and the second weighting factor is greater than a predetermined limit, while a predilution is concluded when the difference between the first weighting factor and the second weighting factor is less than the predetermined limit.
- the device for detecting the supply of substitution fluid of the extracorporeal blood treatment device has a measuring unit for measuring the pressure in the bloodstream downstream of the dialyzer or filter and an evaluation unit, which in turn means for obtaining the comprising oscillating pressure signal due to the substituate pump, means for comparing the oscillating pressure signal with a characteristic reference signal and means for detecting pre- or postdilution based on the comparison of the oscillating pressure signal of the substituate pump with the characteristic reference signal.
- pre- or post-dilution can be made at the beginning of the dialysis treatment alone with the evaluation of the pressure signal of the substituate pump, but preferably in conjunction with the pressure signal of the blood pump.
- the method according to the invention and the device according to the invention are advantageously used in the determination of the dialysis dose by means of so-called online clearance monitoring (OCM) and in the case of a substituate specification as a function of the blood flow.
- OCM online clearance monitoring
- the method and apparatus also provide decision guidance in all relevant dialysis related parameters when a distinction between postdilutive and predilutive substitution is necessary.
- the method and the device can also be used in the determination of the blood flow, the determination of the shunt or fistula recirculation, in the monitoring of the relative blood volume or hematocrit, the determination of the filling volumes of the dialyzer or filter and the detection of the venous needle type.
- the venous pressure sensor may be used to measure the pressure in the Blood circulation downstream of the dialyzer or filter are used.
- the equipment cost is relatively low.
- FIG. 1 shows a simplified schematic representation of the essential components of a hemo (dia) filtration device together with a means for detecting the supply of substitution fluid in the extracorporeal blood circulation upstream or downstream of the dialyzer or filter. Whenever a dialyzer is mentioned below, it also means a filter.
- the hemo (dia) filtration device has a dialyzer 1, which is separated by a semipermeable membrane 2 into a first chamber 3 through which blood flows and a second chamber 4 through which the dialysis fluid flows.
- the first chamber 3 is connected in an extracorporeal blood circuit 5A, while the second chamber 4 is connected in the fluid system 5B of the hemo (dia) filtration device.
- the extracorporeal blood circuit 5A comprises an arterial blood line 6 leading to the inlet 3a of the blood chamber 3 and a venous blood line 7 leaving the outlet 3b of the blood chamber 3 of the dialyzer 1.
- an arterial drip chamber 8 and in the venous blood line 7 a venous drip chamber 9 are connected in the arterial blood line 6.
- the blood of the patient is conveyed through the blood chamber of the dialyzer by means of an arterial blood pump 10, in particular roller pump, which is arranged on the arterial blood line 6.
- the fluid system 5B includes a dialysis fluid supply line 11 leading to the inlet 4a of the dialysis fluid chamber 4, and a dialysis fluid discharge line 12 departing from the outlet 4b of the dialysis fluid chamber 4 of the dialyzer 1.
- About the Dialysier crampkeitszu slaughtertechnisch 11 flows fresh dialysis fluid from a Dialysis fluid not shown in the dialysis fluid, while the used dialysis fluid is discharged from the dialysis fluid through the dialysis fluid 12 to a drain, not shown.
- the balancing device generally provided in the hemo (dia) filtration devices for balancing fresh versus used dialysis fluid is not shown for the sake of clarity. Also, additional facilities for cleaning and flushing the system are not shown.
- the dialysis fluid supply line 11 comprises a first portion 11a leading to the inlet 13a of a first chamber 13 of a sterile filter 16 divided by a membrane 14 into the first chamber and a second chamber 15, and a second portion 11b extending from the outlet 13b of FIG first chamber 13 of the filter 16 and leads to the inlet 4a of the dialysis fluid chamber 4.
- substitution fluid line 17 can be supplied from the liquid system 5B as substitution liquid via a substitution fluid line 17 to the extracorporeal blood circuit 5A.
- the liquid line 17 has two line sections 17a, 17b, 17c, 17d at both ends.
- the line section 17a is connected to the first outlet 15a of the sterile filter 16, while a connector 18a, 18b is connected to the line sections 17c and 17d.
- the substitution fluid line 17 can be connected to a connecting line 19 leading to the arterial drip chamber 8 or a connecting line 20 leading to the venous drip chamber 9.
- the connection lines 19, 20 have for this purpose corresponding connection pieces 19a, 20a.
- hose clamps 17e, 17f On the hose line sections 17c, 17d sit hose clamps 17e, 17f, with which optionally a fluid connection can only be made to the arterial or venous drip chamber 8, 9. But it is also possible that the substitution liquid line 17 connected to two connecting lines 19, 20 and both hose clamps 17e, 17f are open.
- a shut-off device 21 for example a hose clamp is provided, which is preferably actuated electromagnetically.
- the substitution fluid is conveyed by means of an occlusion pump, in particular roller pump 22, into which the substitution fluid line 17 is inserted.
- roller pumps are state of the art. They have a plurality of rollers 22a, 22b, with which the cross section of the hose line for conveying the liquid can be reduced. This creates pressure waves that can propagate in both directions via the substitution fluid line.
- a pressure wave generating occlusion pump is not required as a substituate pump in the first embodiment of the blood treatment apparatus of the present invention. Rather, a substituate pump which does not generate pressure waves can also be used to promote the substitution fluid. This is an advantage of this embodiment.
- an electromagnetically actuated shut-off device 25, 26 is provided in the dialysis fluid supply line 11 upstream and in the diatizing fluid discharge line 12 downstream of the dialyzer 1.
- the blood pump 10, the substituate pump 22 and the shut-off elements 21, 25 and 26 are connected via control lines 10 ', 22', 21 ', 25' and 26 'to a central control and regulation unit 27, of which the individual components taking into account predetermined treatment parameters are controlled.
- the obturator 21 is closed, wherein dialyzing fluid flows through the dialysis fluid chamber 4 of the dialyzer.
- the obturator 21 is opened, so that sterile sterile filter 16 Dialysis fluid as substitution fluid either in the arterial drip chamber 8 (predilution) or venous drip chamber 9 (postdilution) flows.
- the obturator 25 is closed upstream of the dialyzer.
- the device for detecting pre- and post-dilution has a control unit which is part of the central control unit 27 of the blood treatment device.
- the detection device has a measuring unit 28 for measuring the pressure in the extracorporeal blood circulation downstream of the dialyzer 3 and an evaluation unit 29.
- As a measuring unit attached to the drip chamber 9 pressure sensor 28 is provided which generates a dependent of the venous pressure electrical pressure signal.
- the pressure signal of the pressure sensor 28 is supplied via a data line 30 of the evaluation unit 29, which in turn communicates with the control unit 27 via a data line 31.
- the evaluation unit 29 has a low-pass filter 29a for filtering the pressure signal of the pressure sensor 28 and a comparator 29b, with which the pressure signal is compared with a predetermined upper and lower limit.
- the control unit 27 of the detection device preferably switches off the already running substituate pump 22 at the beginning of the blood treatment for the initiation of the measurement. After a predetermined time interval has elapsed, the control unit 27 switches on the substituate pump 22 again. While the substituate pump is turned off, the pressure sensor 28 measures the venous pressure.
- the venous pressure signal of the sensor 28 filtered with the low-pass filter 29a is compared in the comparator 29b of the evaluation unit 29 with an upper and lower limit value in order to increase or decrease the pressure after the substituate pump has been switched off Turning on the Substituatpumpe a pressure drop or after switching off the Substituatpumpe a pressure drop and after switching on the substituate pump to detect a pressure increase:
- FIG. 2A shows the principal temporal course of venous pressure in postdilution and FIG. 2B the time course of the pressure at Predilution. It can be clearly seen that in postdilution the pressure initially increases and then falls off. At Predilution, the pressure initially drops, then increases. On the basis of these two characteristic courses, the evaluation unit recognizes whether there is postdilution or predilution. The result can be visually and / or acoustically displayed on a display unit, not shown.
- FIGS. 3A and 3B show the venous pressure as a function of time in the event that the predetermined time interval in which the Substituatpumpe is turned off, is relatively long. If a shorter time interval is given, the maxima or minima are closer together.
- the already activated substituate pump is switched off for a predetermined time interval. In principle, however, it is also possible to turn on the substituent pump initially switched off for a predetermined time interval.
- the in the FIGS. 2A and 2B The characteristic course of the pressure signal shown is due to the changed viscosity of the blood in pre- or post-dilution.
- postdilution the viscosity of the blood due to the supply of substitution liquid in the venous blood line 7 downstream of the drip chambers 9 is reduced.
- the substituate pump 22 When the substituate pump 22 is stopped, the viscosity of the blood in this portion of the venous blood line increases. Consequently, an increased pressure drop occurs at the venous needle. As a result, the venous pressure increases.
- the substituate pump is turned on again, the viscosity of the blood in the venous blood line 7 downstream of the drip chamber 9 decreases, so that the venous pressure drops.
- a positive pressure pulse occurs Sign and after start of the pump a pressure pulse with a negative sign.
- the pulse width depends on the ratio of the blood volume between the dialysis fluid chamber 3 of the dialyzer 1 and the drip chamber 9 and the blood flow.
- the order of the signs of the pressure pulse reverses. There is a pressure drop when the pump stops and a pressure increase after the pump starts ( FIG. 2B ).
- FIGS. 3A and 3B show mean venous pressure [mmHg] as a function of time during in vitro HDF dialysis treatment with blood flow set to 250 ml / min, substitution rate for pre- and postdilution to 70 ml / min and ultrafiltration rate to 0 ml / hr is.
- the predetermined upper and lower limits are to be set such that they are below or above the maxima or minima.
- the upper and lower limits should be above or below the pressure fluctuations superimposed on the pressure signal.
- a repetition of the pressure pulse train which can be detected in the venous blood line 7 with the venous pressure sensor 28, in the arterial blood line 6, which can be detected with an arterial pressure sensor, indicates a recirculation.
- a measure of the recirculation is the ratio between the integral of the pressure signal of the arterial pressure sensor in a predetermined time interval in which the repetitive negative or positive pressure pulse is and the integral of the pressure signal of the venous pressure sensor 28 in a predetermined time interval in which the negative or positive pressure pulse is.
- the time difference ( ⁇ t) between the start and end of the pressure pulse increase or pressure pulse reduction can be related to the filling volume (V PD ) of the tube segment between the inlet 3a of the dialysis fluid chamber 3 of the dialyzer 1 and the junction of the substitution fluid line 17 , 20 are closed at the drip chamber 9.
- the filling volume (V PD ) of the tube segment between the inlet 3a of the dialysis fluid chamber 3 and the venous needle can be closed if, during the HDF predilution, the predetermined time interval between the stop of the substituate pump 22 and the beginning of the pressure drop or the time interval is multiplied by switching on the substituate pump and the beginning of the pressure increase with the blood delivery rate (Q b ).
- the predetermined time interval between the stop of the substituate pump 22 and the beginning of the pressure drop or the time interval is multiplied by switching on the substituate pump and the beginning of the pressure increase with the blood delivery rate (Q b ).
- the time difference between the stop of the substituate pump and the beginning of the pressure pulse rise or the time difference between the start of the substituate pump and the beginning of the pressure pulse drop is monitored.
- the amplitude of the pressure rise or fall gives information about the type of needle. If the type of needle is known, the hematocrit can be closed accordingly.
- the change in hematocrit during the dialysis treatment can be monitored by the change in the amplitude of the pressure pulses.
- FIG. 4 shows the alternative embodiment of the blood treatment device according to the invention in a simplified schematic representation.
- the blood treatment device differs from FIG. 4 not from the blood treatment device of FIG. 1 , Therefore, the corresponding components are also denoted by the same reference numerals.
- the detection device also has a venous pressure sensor 28 for measuring the pressure in the venous blood line 7.
- the evaluation unit 50 receives the venous pressure signal of the pressure sensor 28 via the data line 30.
- the evaluation unit 50 has a device for Fourier analysis 50a, which performs a Fourier analysis of the venous pressure signal.
- the method for detecting pre- or post-dilution requires that the substituate pump 22 and the blood pump 10 are pressure wave generating pumps, for example occlusion pumps, in particular roller pumps. Since the frequency of the pressure waves generated by the blood pump 10 is much greater than the frequency of the pressure waves of the substituate pump due to the much higher speed of the blood pump compared to the substituate pump, the pressure waves of the blood pump can be distinguished from those of the substituate pump.
- the pressure waves of the substituate pump 22 next to the tube section of the substitution fluid line 17, 19, 20 pass through the tube section of the arterial blood line 6 between drip chamber 8 and Input 3a of the dialysis fluid chamber 3, the dialysis fluid chamber and the venous blood line 7, before they reach the pressure sensor 28.
- the pressure waves do not pass through the dialysis fluid chamber and the associated blood line sections.
- the effect of the dialysis fluid chamber 3 and the associated blood line sections can be described by a transfer function. If the dialyzer and the associated line sections are in the transmission path of the pressure waves, the dynamics of the pressure pulses and their frequency spectrum changes, in particular, higher frequencies are attenuated more.
- the pressure signal measured by the pressure sensor 28 contains both the pressure signal of the blood pump 10 and the substituate pump 22.
- the means for Fourier transformation 50a of the evaluation unit 50 decomposes the pressure signal measured by the pressure sensor 28 of the blood pump 10 and the substituate pump 22 in the on the Blood pump or Substituatpumpe attributed signal components.
- FIGS. 5A and 5B show the frequency spectrum of the venous pressure signal determined by Fourier transformation in the case of post- or predilution.
- the measured values shown in the figures were determined in a laboratory experiment in which the blood flow was set to 300 ml / min, the substituate flow to 80 ml / min and the ultrafiltration rate to 100 ml / h.
- the coefficients of the first harmonic and the higher order harmonics can be seen, which are due to the blood pump 10 and the substituate pump 22.
- the evaluation unit 50 calculates the quotient between a higher-order harmonic, for example the second or third harmonic and the coefficient of the harmonic first order, ie the normalized coefficients of the spectral decomposition.
- the normalized coefficient of the substituate pump represents a first weighting factor
- the normalized coefficient of the blood pump represents a second weighting factor.
- the evaluation unit 50 has a further unit 50b. If the evaluation factor of the substituate pump is significantly above the evaluation factor of the blood pump, a post-dilution is concluded ( Fig. 5A ). If the evaluation factor of the substituate pump is only above or near the substituate pump or if both evaluation factors are even the same, a predilution is concluded ( Fig. 5B ). The detection of pre- or post-dilution on the basis of the comparison of the weighting factors takes place in a device 50c.
- the means 50c for detecting pre- or post-dilution has means for forming the difference between the two weighting factors.
- the difference is compared with a predetermined threshold, which is set in such a way that a distinction can be made between pre- or post-dilution.
- Post-dilution occurs when the difference between the first and second weighting factors is greater than the predetermined threshold
- predilution occurs when the difference between the first and second weighting factors is less than the predetermined threshold.
- the result can be displayed in an optical and / or acoustic display unit, not shown.
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Claims (12)
- Procédé de surveillance de l'apport en liquide de substitution pour un appareil de traitement extracorporel du sang avec un circuit sanguin extracorporel qui comprend un premier compartiment d'un dialyseur ou d'un filtre subdivisé par une membrane en ledit premier compartiment et en un deuxième compartiment, et un système de liquide qui comprend ledit deuxième compartiment du dialyseur ou du filtre, le liquide de substitution étant alimenté en amont ou en aval du dialyseur ou du filtre par une pompe à substitut générant des ondes de pression,
caractérisé en ce que, pour la détection de l'apport en liquide de substitution, la pression du circuit sanguin extracorporel est mesurée en aval du dialyseur ou du filtre,
en ce que le signal de pression à retourner à la pompe à substitut est obtenu à partir du signal de pression oscillant et se propageant dans le circuit sanguin, mesuré en aval du dialyseur ou du filtre,
un apport en liquide de substitution en amont ou en aval du dialyseur ou du filtre étant détecté sur la base de la comparaison du signal oscillant de pression de la pompe à substitut avec un signal de référence caractéristique. - Procédé selon la revendication 1, caractérisé en ce que le sang du circuit sanguin extracorporel est refoulé par une pompe à sang générant des ondes de pression et disposée en amont du dialyseur ou du filtre, et en ce que le signal de pression à retourner à la pompe à substitut est obtenu à partir du signal de pression oscillant et se propageant dans le circuit sanguin, mesuré en aval du dialyseur ou du filtre, un apport en liquide de substitution en amont ou en aval du dialyseur ou du filtre étant détecté sur la base de la comparaison des signaux de pression oscillants de la pompe à sang et de la pompe à substitut.
- Procédé selon la revendication 2, caractérisé en ce qu'une analyse de Fourier du signal de pression mesuré en aval du dialyseur ou du filtre est effectuée pour obtenir les signaux de pression oscillants de la pompe à sang et de la pompe à substitut.
- Procédé selon la revendication 3, caractérisé en ce que l'amplitude d'au moins deux composantes harmoniques de la pompe à substitut est déterminée à partir du signal de pression de la pompe à substitut, et l'amplitude d'au moins deux composantes harmoniques de la pompe à sang à partir du signal de pression de la pompe à sang,
en ce qu'au moins un premier facteur d'évaluation est déterminé à partir d'au moins un quotient d'au moins une composante harmonique d'ordre supérieur et d'au moins une composante harmonique d'ordre inférieur de la pompe à substitut, et en ce qu'au moins un deuxième facteur d'évaluation est déterminé à partir d'au moins un quotient d'au moins une composante harmonique d'ordre supérieur et d'au moins une composante harmonique d'ordre inférieur de la pompe à sang, et
en ce que le ou les premiers, et le ou les deuxièmes facteurs d'évaluation sont comparés entre eux. - Procédé selon la revendication 4, caractérisé en ce qu'il est conclu à un apport en liquide de substitution en aval du dialyseur ou du filtre si la différence entre le premier facteur d'évaluation et le deuxième facteur d'évaluation est supérieure à une valeur limite définie.
- Procédé selon la revendication 4, caractérisé en ce qu'il est conclu à un apport en liquide de substitution en amont du dialyseur ou du filtre si la différence entre le premier facteur d'évaluation et le deuxième facteur d'évaluation est inférieure à une valeur limite définie.
- Appareil de traitement extracorporel du sang, avec un circuit sanguin extracorporel (5A) qui comprend un premier compartiment (3) d'un dialyseur (1) ou d'un filtre subdivisé par une membrane (2) en ledit premier compartiment et en un deuxième compartiment (4), et un système de liquide (5B) qui comprend ledit deuxième compartiment du dialyseur ou du filtre, une conduite de liquide de substitution (17, 19, 20) où est disposée une pompe à substitut (22) générant des ondes de pression débouchant dans le circuit sanguin extracorporel (5A) en amont ou en aval du dialyseur (1) ou du filtre, et* un dispositif de détection de l'apport en liquide de substitution en amont ou en aval du dialyseur (1) ou du filtre,caractérisé en ce que le dispositif de détection de l'apport en liquide de substitution comprend :■ une unité de mesure (28) pour mesurer la pression du circuit sanguin extracorporel (5A) en aval du dialyseur (1) ou du filtre, et■ une unité d'analyse (50), comprenant :■ des moyens (50a) pour l'obtention du signal de pression oscillant sur la pompe à substitut (22) à partir du signal de pression oscillant et se propageant dans le circuit sanguin, mesuré en aval du dialyseur (1) ou du filtre,■ des moyens (50b) pour la comparaison du signal de pression oscillant de la pompe à substitut (22) avec un signal de référence caractéristique, et■ des moyens (50c) pour la détection de l'apport en liquide de substitution en amont ou en aval du dialyseur (1) ou du filtre, sur la base de la comparaison du signal de pression oscillant de la pompe à substitut (22) avec le signal de référence caractéristique.
- Appareil selon la revendication 7, caractérisé en ce qu'une pompe à sang (10) générant des ondes de pression est disposée dans le circuit sanguin (5A) en amont du dialyseur (1) ou du filtre pour refouler le sang, et en ce que l'unité d'analyse (50) comprend en outre :des moyens (50a) pour l'obtention du signal de pression oscillant sur la pompe à sang (10) à partir du signal de pression oscillant et se propageant dans le circuit sanguin, mesuré en aval du dialyseur (1) ou du filtre,les moyens (50c) pour la détection de l'apport en liquide de substitution en amont ou en aval du dialyseur (1) ou du filtre étant réalisés de telle manière que l'apport du liquide de substitution est détecté en amont ou en aval du dialyseur ou du filtre sur la base de la comparaison du signal de pression oscillant de la pompe à substitut (22) avec le signal de pression de la pompe à sang (10).
- Appareil selon la revendication 8, caractérisé en ce que les moyens pour l'obtention des signaux de pression oscillants de la pompe à substitut (22) et de la pompe à sang (10) comprennent un dispositif d'analyse de Fourier (50a) du signal de pression mesuré en aval du dialyseur (1) ou du filtre.
- Appareil selon la revendication 9, caractérisé en ce que le dispositif d'analyse de Fourier (50a) est réalisé
de telle manière que l'amplitude d'au moins deux composantes harmoniques de la pompe à substitut est déterminée à partir du signal de pression oscillant de la pompe à substitut (22), et l'amplitude d'au moins deux composantes harmoniques de la pompe à sang est déterminée à partir du signal de pression oscillant de la pompe à sang (10), au moins un premier facteur d'évaluation étant déterminé à partir d'au moins un quotient d'au moins une composante harmonique d'ordre supérieur et d'au moins une composante harmonique d'ordre inférieur de, la pompe à substitut (22), et au moins un deuxième facteur d'évaluation étant déterminé à partir d'au moins un quotient d'au moins une composante harmonique d'ordre supérieur et d'au moins une composante harmonique d'ordre inférieur de la pompe à sang (10), et
en ce que les moyens (50b) pour la comparaison du signal de pression oscillant sont réalisés de telle manière que le ou les premiers, et le ou les deuxièmes facteurs d'évaluation sont comparés entre eux. - Appareil selon la revendication 10, caractérisé en ce que les moyens (50c) pour la détection de l'apport en liquide de substitution sont réalisés de telle manière qu'il est conclu à un apport en liquide de substitution en aval du dialyseur (1) ou du filtre si la différence entre le premier facteur d'évaluation et le deuxième facteur d'évaluation est supérieure à une valeur limite définie.
- Appareil selon la revendication 10, caractérisé en ce que les moyens (50c) pour la détection de l'apport en liquide de substitution sont réalisés de telle manière qu'il est conclu à un apport en liquide de substitution en amont du dialyseur (1) ou du filtre si la différence entre le premier facteur d'évaluation et le deuxième facteur d'évaluation est inférieure à une valeur limite définie.
Priority Applications (2)
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PL09009766T PL2108391T3 (pl) | 2004-05-11 | 2005-04-28 | Sposób i urządzenie do nadzorowania doprowadzania płynu substytucyjnego podczas pozaustrojowej obróbki krwi |
EP10007776.7A EP2238996B1 (fr) | 2004-05-11 | 2005-04-28 | Méthode et dispositif pour surveiller l'adduction de liquide de substitution pendant un traitement extracorporel du sang |
Applications Claiming Priority (3)
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DE102004023080A DE102004023080B4 (de) | 2004-05-11 | 2004-05-11 | Verfahren und Vorrichtung zur Überwachung der Zufuhr von Substitutionsflüssigkeit während einer extrakorporalen Blutbehandlung |
EP05009278A EP1595560B1 (fr) | 2004-05-11 | 2005-04-28 | Méthode et dispositif pour surveiller l'adduction de liquide de substitution pendant un traitement extracorporel du sang |
US11/128,088 US8747663B2 (en) | 2004-05-11 | 2005-05-11 | Process and device for monitoring the supply of substitution fluid during an extracorporeal treatment of blood |
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EP05009278A Division EP1595560B1 (fr) | 2004-05-11 | 2005-04-28 | Méthode et dispositif pour surveiller l'adduction de liquide de substitution pendant un traitement extracorporel du sang |
EP05009278.2 Division | 2005-04-28 |
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EP10007776.7A Division EP2238996B1 (fr) | 2004-05-11 | 2005-04-28 | Méthode et dispositif pour surveiller l'adduction de liquide de substitution pendant un traitement extracorporel du sang |
EP10007776.7 Division-Into | 2010-07-27 |
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EP2108391A2 EP2108391A2 (fr) | 2009-10-14 |
EP2108391A3 EP2108391A3 (fr) | 2010-03-17 |
EP2108391B1 true EP2108391B1 (fr) | 2011-04-27 |
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EP10007776.7A Active EP2238996B1 (fr) | 2004-05-11 | 2005-04-28 | Méthode et dispositif pour surveiller l'adduction de liquide de substitution pendant un traitement extracorporel du sang |
EP09009766A Not-in-force EP2108391B1 (fr) | 2004-05-11 | 2005-04-28 | Méthode et dispositif pour surveiller l'adduction de liquide de substitution pendant un traitement extracorporel du sang |
EP05009278A Active EP1595560B1 (fr) | 2004-05-11 | 2005-04-28 | Méthode et dispositif pour surveiller l'adduction de liquide de substitution pendant un traitement extracorporel du sang |
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EP10007776.7A Active EP2238996B1 (fr) | 2004-05-11 | 2005-04-28 | Méthode et dispositif pour surveiller l'adduction de liquide de substitution pendant un traitement extracorporel du sang |
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EP05009278A Active EP1595560B1 (fr) | 2004-05-11 | 2005-04-28 | Méthode et dispositif pour surveiller l'adduction de liquide de substitution pendant un traitement extracorporel du sang |
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EP (3) | EP2238996B1 (fr) |
JP (1) | JP4593354B2 (fr) |
AT (1) | ATE444089T1 (fr) |
DE (2) | DE102004023080B4 (fr) |
ES (1) | ES2332412T3 (fr) |
PL (2) | PL1595560T3 (fr) |
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DE102014103492A1 (de) | 2014-03-14 | 2015-09-17 | Fresenius Medical Care Deutschland Gmbh | Flüssigkeitskassette mit kipptoleranter Zentrierverrastung sowie Blutbehandlungsvorrichtung |
DE102014103507A1 (de) | 2014-03-14 | 2015-09-17 | Fresenius Medical Care Deutschland Gmbh | Medizinische Funktionsvorrichtung mit einem Ventilsitz für ein remanentes Rückschlagventil |
JP6488712B2 (ja) * | 2015-01-15 | 2019-03-27 | ニプロ株式会社 | 透析システム、方法、およびプログラム |
DE102015016854A1 (de) * | 2015-12-23 | 2017-06-29 | Fresenius Medical Care Deutschland Gmbh | Dialysegerät mit Mitteln zur Erkennung einer Shunt-Rezirkulation |
DE102016010434B4 (de) * | 2016-08-27 | 2024-07-04 | Fresenius Medical Care Deutschland Gmbh | Blutbehandlungsvorrichtung |
DE102016119259A1 (de) * | 2016-10-10 | 2018-04-12 | B. Braun Avitum Ag | Vorrichtung und Verfahren zur Rezirkulationsmessung |
DE102017210134A1 (de) * | 2016-12-15 | 2018-06-21 | Fresenius Medical Care Deutschland Gmbh | System zur extrakorporalen Blutbehandlung, Behandlungsvorrichtung, Kit und Verfahren zum Betreiben eines Systems zur extrakorporalen Blutbehandlung |
JP6900756B2 (ja) * | 2017-04-13 | 2021-07-07 | 株式会社ジェイ・エム・エス | 血液透析装置における血液回路への補充液ラインの接続状態の判定方法及び判定装置 |
JP7061509B2 (ja) * | 2018-04-26 | 2022-04-28 | 日機装株式会社 | 血液浄化装置 |
GB2579673A (en) * | 2018-12-12 | 2020-07-01 | Haemair Ltd | Cell washing apparatus |
US11974835B2 (en) | 2019-05-31 | 2024-05-07 | iTrend Medical Research Limited | System and method for measuring pressure waves in dialysis lines |
DE102019131140A1 (de) * | 2019-11-19 | 2021-05-20 | B.Braun Avitum Ag | Blutleitungssystem für eine extrakorporale Blutbehandlungsmaschine, und extrakorporale Blutbehandlungsmaschine |
EP4180067B1 (fr) * | 2021-11-10 | 2024-01-03 | Kai-Uwe Ritter | Appareil de traitement sanguin extracorporel |
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Publication number | Priority date | Publication date | Assignee | Title |
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DE3444671A1 (de) | 1984-12-07 | 1986-06-12 | Fresenius AG, 6380 Bad Homburg | Haemodiafiltrationsgeraet |
DE4024434A1 (de) * | 1990-08-01 | 1992-02-13 | Fresenius Ag | Vorrichtung zur ultrafiltrationskontrolle bzw. ultrafiltrationsregelung bei blutreinigungsverfahren |
AU2568800A (en) * | 1999-03-02 | 2000-09-21 | Infomed S.A. | Tubing for extracorporal purification of the blood and use thereof |
DE19917197C1 (de) * | 1999-04-16 | 2000-07-27 | Fresenius Medical Care De Gmbh | Verfahren und Vorrichtung zur Ermittlung des Blutflusses in einem Gefäßzugang |
BR0207303A (pt) * | 2001-02-07 | 2004-06-15 | Nephros Inc | Método e aparelho para um módulo de fornecimento de hemodiafiltração |
DE10115991C1 (de) * | 2001-03-30 | 2002-04-18 | Fresenius Medical Care De Gmbh | Verfahren und Vorrichtung zum Erkennen von Stenosen in einem Schlauchleitungssystem |
DE10159620C1 (de) * | 2001-12-05 | 2003-08-14 | Fresenius Medical Care De Gmbh | Verfahren und Einrichtung zur Überwachung der Zufuhr von Substitutionsflüssigkeit während einer extrakorporalen Blutbehandlung |
DE10213179C1 (de) * | 2002-03-25 | 2003-08-07 | Fresenius Medical Care De Gmbh | Verfahren und Vorrichtung zur Überwachung der Zufuhr von Substitutionsflüssigkeit während einer extrakorporalen Blutbehandlung |
DE10355042B3 (de) * | 2003-11-25 | 2005-06-23 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Vorrichtung zum Erkennen von Störungen des Blutflusses in einem extrakorporalen Blutkreislauf |
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- 2005-04-28 PL PL09009766T patent/PL2108391T3/pl unknown
- 2005-04-28 EP EP10007776.7A patent/EP2238996B1/fr active Active
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- 2005-04-28 EP EP09009766A patent/EP2108391B1/fr not_active Not-in-force
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PL2108391T3 (pl) | 2011-09-30 |
US9750864B2 (en) | 2017-09-05 |
ES2332412T3 (es) | 2010-02-04 |
EP2108391A2 (fr) | 2009-10-14 |
JP4593354B2 (ja) | 2010-12-08 |
EP2238996B1 (fr) | 2019-02-20 |
US20060254982A1 (en) | 2006-11-16 |
DE102004023080A1 (de) | 2005-12-08 |
JP2005324024A (ja) | 2005-11-24 |
PL1595560T3 (pl) | 2010-01-29 |
DE102004023080B4 (de) | 2009-01-15 |
EP2108391A3 (fr) | 2010-03-17 |
DE502005008219D1 (de) | 2009-11-12 |
US8747663B2 (en) | 2014-06-10 |
US20160263304A1 (en) | 2016-09-15 |
US20140246373A1 (en) | 2014-09-04 |
EP1595560B1 (fr) | 2009-09-30 |
EP1595560A1 (fr) | 2005-11-16 |
EP2238996A1 (fr) | 2010-10-13 |
US9364598B2 (en) | 2016-06-14 |
ATE444089T1 (de) | 2009-10-15 |
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