EP2104423A1 - Method for the improved utilization of the production potential of transgenic plants - Google Patents

Abstract

The invention relates to a method for better utilizing the production potential of transgenic plants by using 3-aryl-pyrrolidine-2,4-dione derivatives.

Description

 Method for improved utilization of the production potential of transgenic plants

The invention relates to a method for improving the utilization of the production potential of transgenic plants.

The proportion of transgenic crops in agriculture has increased significantly in recent years, although regional differences are still discernible. For example, the proportion of transgenic maize in the United States has doubled from 26% to 52% since 2001, whereas transgenic maize in Germany has hardly played a practical role so far. However, in other European countries, such as Spain, the proportion of transgenic maize is already around 12%.

Transgenic plants are mainly used to use the production potential of the respective plant variety as low as possible with the use of production resources as low as possible. The aim of the genetic modification of the plants is primarily to produce a resistance in the plants against certain pests or harmful organisms or else herbicides and against abiotic stress (for example drought, heat or elevated salt contents). Likewise, a plant may be genetically modified to produce certain quality or product characteristics, such as e.g. To increase the content of selected vitamins or oils, or to improve certain fiber properties.

A herbicide resistance or tolerance can be achieved for example by the incorporation of genes into the crop for the expression of enzymes for detoxification of certain herbicides, which thus can grow as freely as possible, even in the presence of these herbicides for controlling weeds and grass weeds. Examples include cotton varieties or corn varieties that tolerate the herbicidal active ingredient Gyphosate (Roundup®), (Roundup Ready®, Monsanto) or the herbicides glufosinate or oxynil.

More recently, crops that contain two or more genetic alterations ("stacked transgenic plants") have been developed, for example Monsanto has developed multi-transgenic maize varieties that target the European corn borer {Ostήnia nubilalis) and the Also known are corn or cotton crops that are resistant to both the Western corn rootworm and the cotton bollworm, as well as the herbicide Roundup®. It has now been found that the use of the production potential of transgenic crops can be further improved if the plants are treated with one or more 3-arylpyrrolidine-2,4-dione derivative (s). In this context, the term "treatment" includes all measures which lead to contact between these active substances and at least one plant part. "Plant parts" are to be understood as meaning all aboveground and underground parts and organs of the plants, such as shoot, leaf, flower and root. By way of example, leaves, needles, stems, stems, flowers, fruiting bodies, fruits and seeds, as well as roots, tubers and rhizomes are listed. The plant parts also include crops and vegetative and generative propagation material, such as cuttings, tubers, rhizomes, offshoots and seeds.

3-Arylpyrrolidine-2,4-dione derivatives and their herbicidal or insecticidal activities are well known in the art. For example, EP-A-355 599 and EP-A-415 211 disclose bicyclic 3-aryl-pyrrolidine-2,4-dione derivatives. From EP-A-377 893 and EP-A-442 077 substituted monocyclic 3-aryl-pyrrolidine-2,4-dione derivatives are known. Also known are polycyclic 3-arylpyrrolidine-2,4-dione derivatives (EP-A-442 073) and tetramic acid derivatives from EP-A-456 063, EP-A-521 334, EP-A-596 298, EP-A -613,884, WO 95/01 997, WO 95/26 954, WO 95/20 572, EP-A-0 668 267, WO 96/25 395, WO 96/35 664, WO 97/01 535, WO 97/02 243, WO 97/36 868, WO 97/43 275, WO 98/05 638, WO 98/06 721, WO 98/25 928, WO 99/16748, WO 99/24 437, WO 99/43 649, WO 99/48869, WO 99/55 673, WO 01/09 092, WO 91/17972, WO 01/23 354, WO 01/74 770, WO 03/013 249, WO 2004/007 448, WO 2004 024 688, WO 04/065 366, WO 04/080 962, WO 04/111 042, WO 05/044 791, WO 05/044 796, WO 05/048 710, WO 05/049 596, WO 05/066 125, WO 05/092 897, WO 06/000 355, WO 06/029799, WO 06/056281 and WO 06/056282.

From these documents, methods for the preparation, use and effect of 3-arylpyrrolidine-2,4-dione derivatives (3-APD) are readily known to those skilled in the art. Therefore, they are referred to the invention in terms of active ingredients and their preparation and use in full reference.

The 3 -APD usable according to the invention have the general formula (I) as follows:

in which

X is halogen, alkyl, alkoxy, haloalkyl, haloalkoxy or cyano,

W, Y and Z independently of one another represent hydrogen, halogen, alkyl, alkoxy, haloalkyl, haloalkoxy or cyano,

A is hydrogen, in each case optionally halogen-substituted alkyl, alkoxyalkyl, saturated, optionally substituted cycloalkyl in which optionally at least one ring atom is replaced by a heteroatom,

B is hydrogen or alkyl,

A and B, together with the carbon atom to which they are attached, represent a saturated or unsaturated unsubstituted or substituted cycle, optionally containing at least one heteroatom,

D is hydrogen or an optionally substituted radical from the group consisting of alkyl, alkenyl, alkoxyalkyl, saturated cycloalkyl, in which optionally one or more ring members are replaced by heteroatoms,

A and D together with the atoms to which they are bonded represent a saturated or unsaturated and optionally at least one heteroatom-containing, unsubstituted or substituted in the A, D-part cycle,

G is hydrogen (a) or one of the groups

o _L R ⁴

^ R ¹ (b), ' ^R2 CO. / ^SO ^ ^R3 (d). ^~ J ^ _(e) ,

E (f) or> - N / ' ^R6 _{(g) ι} L ^R

stands,

wherein

E is a metal ion or an ammonium ion,

L is oxygen or sulfur, -A-

M is oxygen or sulfur,

RI is in each case optionally halogen-substituted alkyl, alkenyl, alkoxyalkyl, alkylthioalkyl, polyalkoxyalkyl or optionally halogen, alkyl or alkoxy-substituted cycloalkyl which may be interrupted by at least one heteroatom, in each case optionally substituted phenyl, phenylalkyl, hetaryl, phenoxyalkyl or hetaryloxyalkyl stands,

R.2 is in each case optionally halogen-substituted alkyl, alkenyl, alkoxyalkyl, polyalkoxyalkyl or in each case optionally substituted cycloalkyl, phenyl or benzyl,

R 3 represents optionally halogen-substituted alkyl or optionally substituted phenyl,

R ^ and R ^ independently of one another are each optionally halogen-substituted alkyl, alkoxy, alkylamino, dialkylamino, alkylthio, alkenylthio, cycloalkylthio or in each case optionally substituted phenyl, benzyl, phenoxy or phenylthio and

RÖ and R ^ independently of one another represent hydrogen, in each case optionally halogen-substituted alkyl, cycloalkyl, alkenyl, alkoxy, alkoxyalkyl, optionally substituted phenyl, optionally substituted benzyl or together with the N-atom to which they are attached, optionally are interrupted by oxygen or sulfur optionally substituted ring.

In a preferred embodiment of the invention, at least one insecticidally active 3-APD derivative is used to treat transgenic crops. The term "insecticidally active" or "insecticide" for the purposes of the invention includes insecticidal, acaricidal, molluscicidal, nematicidal, ovicidal effects, as well as a repellent, behavior modifier or sterilizing effect on pests.

Preferred insecticidal active compounds are compounds of the formula (I) in which

W is preferably hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, chlorine, bromine or fluorine,

X is preferably C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkyl, fluorine, chlorine or bromine, Y and Z independently of one another preferably represent hydrogen, C 1 -C 4 -alkyl, halogen, C 1 -C 4 -alkoxy or C 1 -C 4 -haloalkyl,

A is preferably hydrogen or in each case optionally halogen-substituted C ₁ -C ₆ -alkyl or C ₃ -C 9 -cycloalkyl,

B is preferably hydrogen, methyl or ethyl,

A, B and the carbon atom to which they are attached preferably represent saturated C3-C ₆ - cycloalkyl in which optionally one ring member is replaced by oxygen or sulfur and which is optionally monosubstituted or disubstituted by Ci-Gj-alkyl, trifluoromethyl or C C ₄ -alkoxy is substituted,

D is preferably hydrogen, in each case optionally fluorine- or chlorine-substituted C ₁ -C ₆ -alkyl, C ₃ -C ₄ -alkenyl or C ₃ -C ₆ -cycloalkyl,

A and D together preferably represent in each case optionally methyl-substituted C ₃ -C ₄ -alkanediyl, in which optionally a methylene group is replaced by sulfur,

G is preferably hydrogen (a) or one of the groups

o _L R ⁴

R ^ ¹ (b), Λ _U - ^RZ Co. / ^SC ^ ^{R 3 OD,} -γ ^ _(e),

R ⁶

E © or \ ^- N '\ ^ ₇ 7 (g) in particular stands for (a), (b), (c) or (g)

in which

E is a metal ion or an ammonium ion,

L stands for oxygen or sulfur and

M is oxygen or sulfur,

R ¹ preferably represents in each case optionally halogen-substituted Ci-Cio-alkyl, C ₂ -C ₀ - alkenyl, _{Ci-C4-alkoxy-Ci-C4-alkyl, Ci-C4-alkylthio-Ci-C 4} alkyl or C ₃ -C ₆ -cycloalkyl optionally substituted by fluorine, chlorine, C ₁ -C ₄ -alkyl or C ₁ -C ₂ -alkoxy, optionally substituted by fluorine, chlorine, bromine, cyano, nitro, C ₁ -C ₄ -alkyl, C _{r is} C ₄ -alkoxy, Trifluoromethyl or trifluoromethoxy-substituted phenyl, in each case optionally substituted by chlorine or methyl-substituted pyridyl or thienyl,

R ² preferably represents in each case optionally substituted by fluorine or chlorine, Ci-Cio-alkyl, C ₂ -C _O alkenyl, Ci-C ₄ -alkoxy-C ₂ -C ₄ alkyl, optionally substituted by methyl or methoxy-substituted C ₅ - C ₆ -cycloalkyl or is in each case optionally substituted by fluorine, chlorine, bromine, cyano, nitro, C 1 -C ₄ -alkyl, C 1 -C ₄ -alkoxy, trifluoromethyl or trifluoromethoxy-substituted phenyl or benzyl,

R ³ preferably represents optionally fluorine-substituted C 1 -C ₄ -alkyl or each optionally substituted by fluorine, chlorine, bromine, C 1 -C ₄ -alkyl, C 1 -C ₄ -alkoxy, trifluoromethyl, trifluoromethoxy, cyano or nitro-substituted phenyl .

R ⁴ preferably represents in each case optionally substituted by fluorine or chlorine, C _r C ₄ alkyl, Ci-C ₄ alkoxy, Ci-C ₄ alkylamino, _{Ci-C4-alkylthio,} or represents in each case optionally substituted by fluorine, chlorine, bromine, nitro , cyano, Ci-C ₄ alkoxy, trifluoromethoxy, Ci-C ₄ alkylthio, _Q-C4 haloalkylthio, Ci-C ₄ -alkyl or trifluoromethyl-substituted phenyl, phenoxy or phenylthio,

R ^{5 is} preferably C 1 -C ₄ -alkoxy or C 1 -C ₄ -thioalkyl,

R ⁶ preferably represents C _r C ₆ alkyl, C ₃ -C ₆ cycloalkyl, C, -C ₆ alkoxy, C ₃ -C ₆ alkenyl, QC ₄ - alkoxy-C _r C ₄ -alkyl,

R ⁷ preferably represents QC ₆ alkyl, C ₃ -C ₆ alkenyl or C _r C ₄ alkoxy-C _r C ₄ alkyl,

R ⁶ and R ⁷ together preferably represent an optionally substituted by methyl or ethyl C ₃ -C ₆ -alkylene in which optionally a carbon atom is replaced by oxygen or sulfur.

Particular preference is given to compounds of the formula (I) in which

W particularly preferably represents hydrogen, methyl, ethyl, chlorine, bromine or methoxy,

X particularly preferably represents chlorine, bromine, methyl, ethyl, propyl, i-propyl, methoxy, ethoxy or trifluoromethyl,

Y and Z more preferably independently of one another represent hydrogen, fluorine, chlorine, bromine, methyl, ethyl, propyl, isopropyl, trifluoromethyl or methoxy, A particularly preferably represents methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, cyclopropyl, cyclopentyl or cyclohexyl,

B particularly preferably represents hydrogen, methyl or ethyl,

A, B and the carbon atom to which they are attached are particularly preferably saturated Cβ-cycloalkyl, in which optionally a ring member is replaced by oxygen and which is optionally monosubstituted by methyl, ethyl, methoxy, ethoxy, propoxy or butoxy,

D is particularly preferably hydrogen, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, allyl, cyclopropyl, cyclopentyl or cyclohexyl,

A and D together are particularly preferred for optionally methyl-substituted C ₃ -C ₄ -alkanediyl,

G is particularly preferably hydrogen (a) or one of the groups

^<9) ,

in which

M is oxygen or sulfur,

R ¹ particularly preferably represents C ₁ -C ₆ -alkyl, C ₂ -C ₄ -alkenyl, methoxymethyl, ethoxymethyl, ethylthiomethyl, cyclopropyl, cyclopentyl or cyclohexyl,

optionally substituted by fluorine, chlorine, bromine, cyano, nitro, methyl, ethyl, methoxy, trifluoromethyl or trifluoromethoxy phenyl,

is in each case optionally substituted by chlorine or methyl substituted pyridyl or thienyl,

R ² particularly preferably represents C ₁ -C ₆ -alkyl, C ₂ -C ₄ -alkenyl, methoxyethyl, ethoxyethyl or represents phenyl or benzyl, R ⁶ and R ⁷ independently of one another particularly preferably represent methyl, ethyl or together represent a C ₅ -alkylene radical in which the C ₃ -methylene group is replaced by oxygen.

Particular preference is given to compounds of the formula (I) in which

W very particularly preferably represents hydrogen or methyl,

X very particularly preferably represents chlorine, bromine or methyl,

Y and Z very particularly preferably independently of one another represent hydrogen, chlorine, bromine or methyl,

A, B and the carbon atom to which they are attached are very particularly preferably saturated C ₆ -cycloalkyl, in which optionally a ring member is replaced by oxygen and which is optionally monosubstituted by methyl, trifluoromethyl, methoxy, ethoxy, propoxy or butoxy .

G is very particularly preferably hydrogen (a) or one of the groups

^{(9) l} '

in which

M is oxygen or sulfur,

R ¹ very particularly preferably for Cj-Cg-alkyl, C ₂ -C ₄ - alkenyl, methoxymethyl, ethoxymethyl, ethylthiomethyl, cyclopropyl, cyclopentyl, cyclohexyl or

optionally substituted by fluorine, chlorine, bromine, methyl, methoxy, trifluoromethyl, trifluoromethoxy, cyano or nitro phenyl,

is in each case optionally substituted by chlorine or methyl substituted pyridyl or thienyl,

R ² very particularly preferably represents C ₁ -C ₈ -alkyl, C ₂ -C ₄ -alkenyl, methoxyethyl, ethoxyethyl, phenyl or benzyl, R ⁶ and R ⁷ independently of one another very particularly preferably represent methyl, ethyl or together represent a Cs-alkylene radical in which the C ₃ -methylene group is replaced by oxygen.

Depending on the nature of the substitution, the compounds of the formula (I) can also be present as optical isomers or mixtures of isomers in different compositions.

Particular preference is given to compounds of the abovementioned formula (I) in which the radicals have the following meaning:

in the form of their cis / trans isomer mixtures or their pure cis isomers.

Highlighted are the cis isomers of the formula (1-3) and (1-4)

(1-3) (1-4)

The compounds of formula (I) are - as mentioned above - known in the art; as well as their preparation (see in particular WO 97/01 535, WO 97/36 868, WO 98/05 638, WO 04/007 448).

Preference is given to mixtures of two or more, preferably two or three, particularly preferably two, of the insecticidally active compounds.

According to the method proposed according to the invention, transgenic plants, in particular crops, are treated with 3-APD derivatives in order to increase agricultural productivity. In the context of the invention, transgenic plants are plants which code at least one gene or gene fragment which they have not taken over by fertilization. This gene or gene fragment may be derived or derived ("foreign gene") from another plant of the same species, from plants of different species, but also from organisms from the animal kingdom or microorganisms (including viruses) and / or may already be natural The use of synthetic genes is also possible according to the invention and is also subsumed here under the term "foreign gene". It is also possible that a transgenic plant encodes two or more foreign genes of different origin. The "foreign gene" in the sense of the invention is furthermore characterized in that it comprises a nucleic acid sequence which exerts a specific biological or chemical function or activity in the transgenic plant .These genes generally encode biocatalysts, such as, for example, enzymes or ribozymes. or include regulatory sequences such as promoters or terminators for influencing the expression of endogenous proteins, but may also encode regulatory proteins such as repressors or inducers, and the foreign gene may also serve the targeted localization of a gene product of the transgenic plant, for example Also inhibitors such as antisense RNA can be encoded by the foreign gene.

Various methods for the production of transgenic plants as well as methods for targeted mutagenesis, gene transformation and cloning are readily known to those skilled in the art, for example from: Willmitzer, 1993, Transgenic plants, In: Biotechnology, A Multivolume Comprehensive Treatise, Rehm et al. (eds.), Vol. 2, 627-659, VCH Weinheim, Germany; McCormick et al., 1986, Plant Cell Reports 5: 81-84; EP-A 0221044; EP-A-0131624, or Sambrook et al., 1989, "Molecular Cloning: A Laboratory Manual", 3rd Ed., Col. Spring Harbor Laboratory Press, ColD Spring Harbor, NY; Winnacker, 1996, "Genes and Clones", 2nd ed., VCH Weinheim or Christou, 1996, Trends in Plant Science 1: 423-431. Examples of transit or signal peptides or time or site specific promoters are e.g. in Braun et al., 1992, EMBO J. 11: 3219-3227; Wolter et al., 1988, Proc. Natl. Acad. Be. USA 85: 846-850; Sonnewald et al., 1991, Plant J. 1: 95-106.

An example of a complex genetic manipulation of a crop is the so-called GURT technology ("Genetic Use Restriction Technologies"), which is used for technical control of the propagation of the respective transgenic plant species, usually two or three foreign genes are cloned into the crop which, in a complex interplay following the delivery of an external stimulus, trigger a cascade that results in the death of the otherwise developing embryo, for example, the external stimulus (eg, an agent or another chemical or abiotic stimulus) may interact with a repressor thus no longer suppress expression of a recombinase so that the recombinase can cleave an inhibitor and thus allow the expression of a toxin causing the embryo to die off Examples of this type of transgenic plants are disclosed in US 5,723,765 or US 5,808,034. Accordingly, those skilled in the art are familiar with methods for generating transgenic plants which have altered properties due to the integration of regulatory foreign genes and the optionally mediated overexpression, suppression or inhibition of endogenous genes or gene sequences or the existence or expression of foreign genes or their fragments.

As already stated above, the method according to the invention makes it possible to improve the utilization of the production potential of transgenic plants. On the one hand, this may possibly be attributable to the fact that the amount of Aurwand of the active substance which can be used according to the invention can be reduced; for example, by reducing the dose used or by reducing the number of applications. On the other hand, if necessary, the yield of crops can be increased quantitatively and / or qualitatively. This is especially true in a transgenic resistance to biotic or abiotic stress. For example, if insecticidal 3-APD is used, the dosage of the insecticide may u. be limited to a sub-lethal dose without significantly attenuating the desired effect of the active ingredient on the pests.

These synergistic effects can vary depending on the plant species or plant cultivars, their location and growth conditions (soils, climate, vegetation period, diet) and can be diverse. Thus, for example, reduced application rates and / or extensions of the spectrum of action and / or an increase in the effect of the substances and agents usable in the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering power facilitated harvest, acceleration of ripeness, higher crop yields, higher quality and / or higher nutritional value of the harvested products, higher shelf life and / or machinability of the harvested products, which exceed the actual expected effects.

These advantages are attributable to a synergistic effect achieved according to the invention between the usable 3 -APD and the respective mode of action of the genetic modification of the transgenic plant. With this due to the synergism reduction of the means of production with simultaneous increase in yield or quality considerable economic and environmental benefits are associated.

A list of examples of transgenic plants known to the person skilled in the art, with reference in each case to the structure in question in the plant or in the plant expressed by the genetic modification, is compiled in Table 1. This is the affected one Structure or the expressed principle in each case assigned a specific feature expression in the sense of a tolerance to a certain stress factor. A similar list (Table 3) also provides, in somewhat different order, examples of modes of action, induced tolerances and potential crops. Further examples of transgenic plants which are suitable for the treatment according to the invention are compiled in Tables 4 and 5 and 6.

In an advantageous embodiment, the 3-APD are used for the treatment of transgenic plants containing at least one gene or gene fragment for coding a Bt toxin. A Bt toxin is a protein originally derived or derived from the soil bacterium, Bacillus thuringiensis, which belongs to either the group of crystal toxins (Cry) or cytolytic toxins (Cyt). They are originally formed in the bacterium as protoxins and are only in an alkaline environment - for example, in the digestive tract of certain feeding insects - metabolized to its active form. There, the then active toxin binds to certain hydrocarbon structures on cell surfaces and causes pore formation, which can destroy the osmotic potential of the cell and thus cause cell lysis. The death of insects is the result. Above all, Bt toxins are effective against certain pest species of the order Lipidoptera (butterflies), Homoptera, Diptera (fly) and Coleoptera (beetles) in all their stages of development; from the Eilarve to her juvenile to her adult forms.

It has long been known to clone gene sequences encoding Bt toxins, parts thereof, or Bt toxin-derived proteins or peptides into agricultural crops using genetic engineering techniques, and thus to generate transgenic plants with endogenous resistance to Bt toxin-susceptible pests. The transgenic plants encoding at least one Bt toxin or proteins derived therefrom are defined as "Bt plants" for the purposes of the invention.

The "first generation" of such Bt plants usually contained only the genes that allowed the formation of a specific toxin and thus made it resistant only to a group of pests, examples of a commercially available maize strain containing the gene for the formation of CrylAb Toxins is "YieldGard®" from Monsanto, which is resistant to the European corn borer. The resistance against other pest pathogens of the family of Lepidoptera, however, is generated in the Bt cotton variety (Bollgard®) by cloning the genes to form the CrylAc toxin. Still other transgenic crop plants express genes for the production of Bt toxins with action against pathogens from the order of coleopterans. When Examples include the Bt potato variety "NewLeaf®" (Monsanto), which can form the Cry3A toxin and is thus resistant to the Colorado beetle ("Colorado Potatoe Beeile"), or the transgenic maize variety "YieldGard®" (Monsanto), which form the Cry 3BbI toxin and thus protected against various species of corn rootworm.

In a "second generation" the multi-transgenic plants already described above were generated which contain or express at least two foreign genes.

According to the invention, preference is given to transgenic plants with Bt toxins from the group of the Cry family (see, for example, Crickmore et al., 1998, Microbiol. Mol. Biol. Rev. 62: 807-812), which are particularly effective against Lepidoptera, Coleoptera or Diptera. Examples of genes encoding the proteins are:

crylAal, crylAa2, crylAa3, crylAa4, crylAa5, crylAaβ, crylAa7, crylAaδ, crylAa9, crylAalO, crylAal 1crylAbl, crylAb2, crylAb3, crylAb4, crylAb5, crylAbό, crylAb7, crylAbδ, crylAb9, crylAblO, crylAbl l, crylAbl2, crylAbl3, crylAbH , crylAcl, crylAc2, crylAc3, crylAc4, crylAc5, crylAcβ, crylAc7, crylAcδ, crylAc9, crylAclO, crylAcl1, crylAcl2, crylAcl3, crylAdl, crylAd2, crylAel, crylAfl, crylAgl, crylBal, crylBa2, crylBbl, crylBcl, crylBdl, crylBel, crylCal, crylCa2, crylCa3, crylCa4, crylCa5, crylCaO, crylCa7, crylCbl, crylCb2, crylDal, crylDa2, crylDbl, crylEal, crylEa2, crylEa3, crylEa4, crylEa5, crylEaO, crylEbl, crylFal, crylFa2, crylFbl, crylFb2, crylFb3, crylFb4, crylGal, crylGa2, crylGbl, crylGb2, crylHal, crylHbl, cryllal, crylla2, crylla3, crylla4, crylla5, cryllaό, cryllbl, cryllcl, crylldl, cryllel, cryll-like, crylJal, crylJbl, crylJcl, crylKal, cryl- like, cry2Aal, cry2Aa2, cry2Aa3, cry2Aa4, cry2Aa5, cry2Aa6, cry2Aa7, cry2Aa8, cry2Aa9, cry2Abl, cry2Ab2, cry2Ab3, c ry2Acl, cry2Ac2, cry2Ala, cry3Aa4, cry3Aa5, cry3Aa3, cry3Aa4, cry3Aa5, cry3Aa6, cry3Aa7, cry3Bal, cry3Ba2, cry3Bbl, cry3Bb2, cry3Bb3, cry3Cal, cry4Aal, cry4Aa2, cry4Bal, cry4Ba2, cry4Ba3, cry4Ba4, cry5Aal, cry5Abl, cry5Acl, cry5Bal, cryöAal, cryόBal, cry7Aal, cry7Abl, cry7Ab2, cry8Aal, cryδBal, cryδCal, cry9Aal, cry9Aa2, cry9Bal, cry9Cal, cry9Dal, cry9Da2, cry9Eal, cry9 like, crylOAal, crylOAa2, cryllAal, cryllAa2, cryllBal, cryllBbl, cryl2Aal, cryl3Aal , cryl4Aal, cryl5Aal, crylAal, cryl7Aal, cryl8Aal, crylδBal, crylδCal, cryl9Aal, cryl9Bal, cry20Aal, cry21Aal, cry21Aa2, cry22Aal, cry23Aal, cry24Aal, cry25Aal, cry26Aal, cry27Aal, cry28Aal, cry28Aa2, cry29Aal, cry30Aal, cry31Aal, cytal, cytAAa2 , cytlAa3, cytlAa4, cytlAbl, cytLBal, cyt2Aal, cyt2Bal, cyt2Ba2, cyt2Ba3, cyt2Ba4, cyt2Ba5, cyt2Ba6, cyt2Ba7, cyt2Ba8, cyt2Bbl. Particularly preferred are the genes or gene segments of the subfamilies cryl, cry2, cry3, cry5 and cry9, particularly preferred are crylAb, crylAc, cry3A, cry3B and cry9C.

It is furthermore preferred to use plants which, in addition to the genes for one or more Bt toxins, may also contain genes for expression of, for example, a protease or peptidase inhibitor (as in WO-A 95/35031), herbicidal resistance (eg Glufosinate or glyphosate by expression of the pat or bar gene) or to the formation of nematode, fungal or viral resistances (eg by expression of a glucanase, chitinase) contain or express. However, they may also be genetically modified in their metabolic properties so as to exhibit a qualitative and / or quantitative modification of ingredients (e.g., by modifications of energy, carbohydrate, fatty acid, or nitrogen metabolism or affecting metabolite fluxes) (see above).

A list of examples of principles of action which can be introduced into a crop by genetic modification and which are suitable for the treatment according to the invention, alone or in combination, is shown in Table 2. This table contains under the indication "AP" (active principle) the respective active principle and the associated pest to be controlled.

In a particularly preferred variant, the process according to the invention is used for the treatment of transgenic vegetable, maize, soybean, cotton, tobacco, rice, potato and sugar beet varieties. These are preferably Bt plants.

The vegetables or varieties are, for example, the following crops:

o Potatoes: preferably starch potatoes, sweet potatoes and ware potatoes;

o root vegetables: preferably carrots, turnips (turnips, turnips, turnips, turnips, Teltower turnips), salsify, Jerusalem artichoke, root parsley, parsnip, radish and horseradish;

o Tubers: preferably kohlrabi, beetroot, celeriac, radishes and radishes;

o onion vegetables: preferably leek, leek and onions (poplar and seedling);

cabbage: preferably cabbage (white cabbage, red cabbage, kale, savoy cabbage), cauliflower, sprouts, broccoli, kale, marrow cabbage, sea cabbage and Brussels sprouts; o Fruit vegetables: preferably tomatoes (field, shrub, meat, greenhouse, cocktail, industrial and fresh market tomatoes), melons, eggplant, aubergines, peppers (vegetable and spice paprika, Spanish pepper), hot peppers, pumpkin, Zucchini and cucumbers (field, greenhouse, snake and cucumbers);

Vegetable legumes: preferably wild beans (as sword beans, pea beans, flageolet beans, wax beans, dry beans with green and yellow-hulled varieties), runner beans (as sword beans, pea beans, flageolet beans, green beans with green, blue and yellow-hulled varieties), broad beans (broad beans, Broad beans, varieties with white and black spotted flowers), peas (chick peas, chickpeas, peas, raspberries, sugar peas, pea peas, varieties with light and dark green fresh grain) and lentils;

o Leaf and stalk vegetables: preferably Chinese cabbage, lettuce, pickle salad, corn salad, iceberg lettuce, romaine lettuce, le weree salad, endives, radicchio, lollo rosso salad, rocket salad, chicory, spinach, Swiss chard and parsley;

o Other vegetables: preferably asparagus, rhubarb, chives, artichokes, mints, sunflowers, tubers, dill, garden cress, mustard, poppy, peanut, sesame and salad chicory.

Bt vegetables, including exemplary methods for their production, are described in detail, for example, in Barton et al., 1987, Plant Physiol. 85: 1103-1109; Vaeck et al., 1987, Nature 328: 33-37; Fischhoff et al., 1987, Bio / Technology 5: 807-813. Bt vegetable plants are already known as commercially available variants such as the potato variety NewLeaf ^® (Monsanto) beyond. Likewise, US 6,072,105 describes the production of Bt vegetables.

Likewise, Bt cotton is already known in principle, for example from US Pat. No. 5,322,938 or from Prietro-Samsonόr et al., J. Ind. Microbiol. & Biotechn. 1997, 19, 202, and H. Agaisse and D. Lereclus, J. Bacteriol. 1996, 177, 6027. Bt cotton is already commercially available in various variations, for example under the name NuCOTN® (Deltapine (USA)). In the context of the present invention, the Bt cotton NuCOTN33® and NuCOTN33B® is particularly preferred.

The use and production of Bt maize has also been known for a long time, for example from Ishida, Y., Saito, H., Ohta, S., Hiei, Y., Komari, T., and Kumashiro, T. (1996). High efficiency transformation of maize (Zea mayz L.) mediated by Agrobacterium tumefaciens. Nature Biotechnology 4: 745-750. EP-B-0485506 also describes the production of Bt maize plants. Bt maize is also commercially available in various variations, for example under the following names (company / companies in brackets): KnockOut® (Novartis Seeds), NaturGard® (Mycogen Seeds), Yieldgard® (Novartis Seeds, Monsanto, Cargill, Golden Harvest , Pioneer, DeKalb and others), Bt-Xtra® (DeKalb) and StarLink® (Aventis CropScience, Garst et al.). For the purposes of the present invention, the following maize varieties are particularly preferred: KnockOut®, NaturGard®, Yieldgard®, Bt-Xtra® and StarLink®.

Also for soybean Roundup®Ready varieties or varieties are available with a resistance to the herbicide Liberty Link® and treatable according to the invention. In rice, a variety of lines of the so-called "Golden Rice" are available, which are equally characterized by having an increased content of provitamin A by a transgenic modification.Also here are examples of plants that are after the invention Process with the described advantages can be treated.

The method according to the invention is suitable for controlling a multiplicity of harmful organisms which occur in particular in vegetables, maize or cotton, in particular insects and arachnids, very particularly preferably insects. The mentioned pests include:

o from the order of isopods: for example Armadillidium spp., Oniscus spp., Porcellio spp.

o from the order of Diplopoda: for example Blaniulus spp ..

o from the order of Chilopoda for example Geophilus spp., Scutigera spp.

o from the order of the Symphyla: for example Scutigerella spp.

o from the order of Thysanura: for example, Lepisma spp.

o from the order of Collembola: for example Onychiurus spp.

o from the order of Orthoptera: for example Blattella spp., Periplaneta spp., Leucophaea spp., Acheta spp., Gryllotalpa spp., Locusta migratoria migratorioides, Melanoplus spp., Schistocerca spp.

o from the order of Dermaptera: for example Forficula spp. o from the order of Isoptera: for example Reticulitermes spp., Reticulitermes spp., Coptotermes spp.

o from the order of Thysanoptera: for example Frankliniella spp., Kakothrips spp., Hercinothrips spp., Scirtothrips spp., Taeniothrips spp., Thrips spp.

o from the order of Heteroptera: for example Eurygaster spp., Stephanitis spp., Lygus spp., Aelia spp., Eurydema spp., Dysdercus spp., Piesma spp.

o from the order of Homoptera: for example Aleurodes spp., Bemisia spp., Trialeurodes spp., Brevicoryne spp., Cryptomyzus spp., Aphis spp., Eriosoma spp., Hyalopterus spp., Phylloxera spp., Pemphigus spp., Macrosiphum spp., Myzus spp., Phorodon spp., Rhopalosiphum spp., Empoasca spp., Euscelis spp., Eulecanium spp., Saissetia spp., Aonidiella spp., Aspidiotus spp., Nephotettix spp., Laodelphax spp., Nilaparvata spp. , Sogatella spp., Pseudococcus spp., Psylla spp., Aphrophora spp., Aeneolamia spp., Aphidina ssp.,

from the order of Lepidoptera: for example, Pectinophora spp., Bupalus spp., Cheimatobia spp., Cnephasia spp., Hydraecia spp., Lithocolletis spp., Hyponomeuta spp., Plutella spp., Plutella xylostella, Malacosoma spp., Euproctis spp. , Lymantria spp., Bucculatrix spp., Phytometra spp., Scrobipalpa spp., Phthorimaea spp., Gnorimoschema spp., Autographa spp., Evergestis spp., Lacanobia spp., Cydia spp., Pseudociaphila spp., Phyllocnistis spp., Agrotis ^'spp., Euxoa spp., Feltia spp., Earias spp., Heliothis spp., Helicoverpa spp., Bombyx spp., Laphygma spp., Mamestra spp., Panolis spp., Prodenia spp., Spodoptera spp., Trichoplusia spp , Caφocapsa spp., Pieris spp., Chilo spp., Ostrinia spp., Pyrausta spp., Ephestia spp., Galleria spp., Cacoecia spp., Capua spp., Choristoneura spp., Clysia spp., Hofmannophila spp. Homona spp., Tineola spp., Tinea spp., Tortrix spp.

o from the order Coleoptera: for example Anobium spp., Rhizopertha spp., Bruchidius spp., Acanthoscelides spp., Hylotrupes spp., Aclypea spp., Agelastica spp., Leptinotarsa spp., Psylliodes spp., Chaetocnema spp., Cassida Spp., Bothynoderes spp., Clivina spp., Ceutorhynchus spp., Phyllotreta spp., Apion spp., Sitona spp., Bruchus spp., Phaedon spp., Diabrotica spp., Psylloides spp., Epilachna spp., Atomaria spp. , Oryzaephilus spp., Anthonomus spp., Sitophilus spp., Otiorhynchus spp., Cosmopolites spp., Ceuthorrynchus spp., Hypera spp., Dermestes spp., Trogoderma spp., Anthrenus spp., Attagenus spp., Lyctus spp., Meligethes Spp., Ptinus spp., Niptus spp., Gibbium spp., Tribolium spp., Tenebrio spp., Agriotes spp., Conoderus spp., Melolontha spp., Amphimallon spp., Costelytra spp. o from the order Hymenoptera: for example Diprion spp., Hoplocampa spp., Lasius spp., Monomorium spp., Vespa spp.

from the order of Diptera: for example Drosophila spp., Chrysomyxa spp., Hypoderma spp., Tannia spp., Bibio spp., Oscinella spp., Phorbia spp., Pegomyia spp., Ceratitis spp., Dacus spp., Tipula spp ..

o from the class of the Arachnida: for example Scorpio maurus, Latrodectus mactans.

o from the order of Acarina: for example Acarus spp., Bryobia spp., Panonychus spp., Tetranychus spp., Eotetranychus spp., Oligonychus spp., Eutetranychus spp., Eriophyes spp., Phyllocoptruta spp., Tarsonemus spp., Rhipicephalus spp., Rhipicephalus spp., Ixodes spp., Amblyomma spp.

o from the helminth class: for example Meloidogyne spp., Heterodera spp., Globodera spp., Radopholus spp., Pratylenchus spp., Tylenchulus spp., Tylenchorhynchus spp., Rotylenchus spp., Heliocotylenchus spp., Belonoaimus spp., Longidorus Spp., Trichodorus spp., Xiphinema spp., Ditylenchus spp., Aphelenchoides spp., Anguina spp.

o from the class of Gastropoda: for example, Deroceras spp., Arion spp., Lymnaea spp., Galba spp., Succinea spp.

o from the order of Thysanoptera,

o Hemiptera order: for example, species of suborder Sternorrhyncha

Preferably, the inventive method for controlling Agriotes spp., Melolontha spp., Aphis spp., Cnephasia spp., Ostrinia spp., Agrotis spp., Hydraecia spp., Tipula spp., Myzus spp., Bemisia spp., Trialeurodes Spp., Oscinella spp., Tetranychus spp., Lygus spp., Leptinotarsa spp., Psylliodes spp., Phytometra spp., Deroceras spp., Psylla spp., Blaniulus spp., Onychiurus spp., Piesma spp., Atomaria spp. , Aclypea spp., Chaetocnema spp., Cassida spp., Bothynoderes spp., Clivina spp., Scrobipalpa spp., Phthorimaea spp., Gnorimoschema spp., Mamestra spp., Autographa spp., Arion spp., Gryllotalpa spp., Eurydema Spp., Meligethes spp., Ceutorhynchus spp., Phyllotreta spp., Plutella xylostella, Evergestis spp., Lacanobia spp., Pieris spp., Forficula spp., Hypera spp., Apion spp., Otiorhynchus spp., Sitona spp. Acanthoscelides spp., Kakothrips spp., Bruchus spp., Cydia spp., Pseudociaphila spp., Heliothis spp., Helicoverpa spp., Prodenia spp., Spodoptera spp., Chilo spp Diabrotica spp., Aphindina ssp., Frankliniella spp., Kakothrips spp., Hercinothrips spp., Scirtothrips spp., Taeniothrips spp., Thrips spp., Scorpio maurus, Latrodectus mactans.

The active compounds which can be used according to the invention are particularly suitable for controlling insects from the suborder of the plant lice (Sternorrhyncha), in particular for controlling the bladder lice, the root lice, the leaf flea, the Napfschildläuse, the Lupus louse, the Röhrenschildläuse or the lice and lice. This use is described in detail in WO 2006/077071 and is hereby referred to for disclosure purposes.

In particular, the method according to the invention for the treatment of Bt vegetables, Bt maize, Bt cotton, Bt soya, Bt tobacco as well as Bt rice, Bt sugar beets or Bt potatoes is suitable for controlling aphids (Aphidina), whites Flies (Trialeurodes), Thrips (Thysanoptera), Spider mites (Arachnida), Shags or Lice (Coccoidae or Pseudococcoidae).

The active compounds which can be used according to the invention can be employed in customary formulations, such as solutions, emulsions, wettable powders, water- and oil-based suspensions, powders, dusts, pastes, soluble powders, soluble granules, scattering granules, suspension-emulsion concentrates, active substance-impregnated natural products, active ingredient Impregnated synthetic materials, fertilizers and Feinstverkapselungen in polymeric materials.

These formulations are prepared in a known manner, e.g. by mixing the active compounds with extenders, ie liquid solvents and / or solid carriers, if appropriate using surface-active agents, ie emulsifiers and / or dispersants and / or foam-forming agents. The preparation of the formulations is carried out either in suitable systems or before or during use.

Injectable powders are preparations which are uniformly dispersible in water and which, in addition to the active substance except a diluent or inert substance, also contain wetting agents, e.g. polyoxethylated alkylphenols, polyoxethylated fatty alcohols, alkyl or alkylphenol sulfonates and dispersants, e.g. sodium lignosulfonate, 2,2'-dinaphthylmethane-6,6'-disulfonic acid sodium.

Dusts are obtained by grinding the active substance with finely divided solids, for example talc, natural clays such as kaolin, bentonite, pyrophillite or diatomaceous earth. Granules can either be prepared by spraying the active ingredient onto adsorptive, granulated inert material or by applying active substance concentrates by means of Adhesives, for example polyvinyl alcohol, polyacrylic acid sodium or mineral oils, on the surface of carriers such as sand, kaolinites or granulated inert material. It is also possible to granulate suitable active ingredients in the manner customary for the production of fertilizer granules, if desired in admixture with fertilizers.

Excipients which can be used are those which are suitable for imparting special properties to the composition itself and / or preparations derived therefrom (for example spray liquor, seed dressing), such as certain technical properties and / or specific biological properties. Typical auxiliaries are: extenders, solvents and carriers.

As extender, e.g. Water, polar and non-polar organic chemical liquids e.g. from the classes of aromatic and non-aromatic hydrocarbons (such as paraffins, alkylbenzenes, alkylnaphthalenes, chlorobenzenes), alcohols and polyols (which may also be substituted, etherified and / or esterified), ketones (such as acetone, cyclohexanone), Esters (including fats and oils) and (poly) ethers, simple and substituted amines, amides, lactams (such as N-alkylpyrrolidones) and lactones, sulfones and sulfoxides (such as dimethyl sulfoxide).

In the case of using water as an extender, e.g. also organic solvents can be used as auxiliary solvent. Suitable liquid solvents are essentially: aromatics, such as xylene, toluene, or alkylnaphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons, such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons, such as cyclohexane or paraffins, e.g. Petroleum fractions, mineral and vegetable oils, alcohols such as butanol or glycol and their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethyl sulfoxide, and water.

Suitable solid carriers are, for example:

For example, ammonium salts and ground natural minerals, such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth and synthetic minerals, such as finely divided silica, alumina and silicates, as solid carriers for granules in question: eg broken and fractionated natural rocks such Calcite, marble, pumice, sepiolite, dolomite and synthetic granules of inorganic and organic flours and granules of organic material such as paper, sawdust, coconut shells, corn cobs and tobacco stalks; as emulsifying and / or foam-producing agents come into question: eg nonionic and anionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, for example alkylaryl polyglycol ethers, alkylsulfonates, alkyl sulfates, arylsulfonates and protein hydrolysates; suitable dispersants are nonionic and / or ionic substances, for example from the classes of alcohol POE and / or POP ethers, acid and / or POPPOE esters, alkylaryl and / or POP POE ethers, fatty and / or POP-POE adducts, POE and / or POP polyol derivatives, POE and / or POP sorbitan or sugar adducts, alkyl or aryl sulfates, sulfonates and phosphates or the corresponding PO ether adducts. Further suitable oligo- or polymers, for example starting from vinylic monomers, from acrylic acid, from EO and / or PO alone or in combination with, for example, (poly) alcohols or (poly) amines. Furthermore, find use lignin and its sulfonic acid derivatives, simple and modified celluloses, aromatic and / or aliphatic sulfonic acids and their adducts with formaldehyde.

Adhesives such as carboxymethylcellulose, natural and synthetic powdery, granular or latex-type polymers such as gum arabic, polyvinyl alcohol, polyvinyl acetate, and natural phospholipids such as cephalins and lecithins and synthetic phospholipids may be used in the formulations.

Dyes such as inorganic pigments, e.g. Iron oxide, titanium oxide, ferrocyan blue and organic dyes such as alizarin, azo and metal phthalocyanine dyes and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

Other additives may be fragrances, mineral or vegetable optionally modified oils, waxes and nutrients (also trace nutrients), such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

Stabilizers such as cold stabilizers, preservatives, antioxidants, light stabilizers or other chemical and / or physical stability-improving agents may also be present.

These individual formulation types are known in principle and described, for example, in: Winnacker-Kuchler, 1986, "Chemische Technologie", Volume 7, 4th ed., C. Hauser Verlag, Munich; van Falkenberg, 1972-73, "Pesticides Foπnulations", 2nd Ed., Marcel Dekker N.Y .; Martens, 1979, "Spray Drying Handbook", 3rd ed., G. Goodwin Ltd. London.

One of ordinary skill in the art can select suitable formulation aids (see, for example, Watkins, "Handbook of Insecticidal Dust Diluents and Carriers ", 2nd Ed., Darland Books, Caldwell NJ, v. Olphen," Introduction to Clay Colloid Chemistry ", 2nd Ed., J. Wiley & Sons, NY; Marsden," Solvents Guide ", 2nd Ed., Interscience, McCutcheon's, " Detergents and Emulsifiers Annual &quot;, MC Publ. Corp., Ridgewood, NJ; Sisley and Wood, " Encyclopedia of Surface Active Agents &quot;, Chem. Publ. Co. Inc., NY 1964; Schonfeldt, " Surfactant Äthylenoxidaddukte ", Wiss. Verlagsgesell., Stuttgart 1967; Winnacker-Küchler," Chemical Technology ", Volume 7, 4th ed., C. Hanser Verlag Munich 1986.

In a preferred embodiment, the plants or plant parts are treated according to the invention with an oil-based suspension concentrate. An advantageous suspension concentrate is known from WO 2005/084435 (EP 1 725 104 A2). It consists of at least one agrochemically active substance solid at room temperature, at least one "closed" penetrating agent, at least one vegetable oil or mineral oil, at least one nonionic surfactant and / or at least one anionic surfactant and optionally one or more additives from the groups of emulsifying agents Foam-inhibiting agents, preservatives, antioxidants, dyes and / or inert fillers Preferred embodiments of the suspension concentrate are described in WO 2005/084435. Corresponding suspension concentrates on a vegetable oil basis are expressly described in EP 1 725 105 A2 for the present invention 3-APD, both of which are fully incorporated by reference for purposes of the disclosure.

In a further preferred embodiment, the plants or the plant part are treated with agents containing ammonium or phosphonium salts and optionally penetration promoters according to the invention. An advantageous agent is known from DE-05059469. It consists of at least one active substance from the class of 3-APD and at least one ammonium or phosphonium salt, if appropriate, penetration promoters. Preferred embodiments are described in DE-05059469. This document is incorporated by reference for purposes of disclosure.

The formulations generally contain between 0.01 and 98% by weight of active ingredient, preferably between 0.5 and 90%. In wettable powders, the active ingredient concentration is for example about 10 to 90 wt .-%, the remainder to 100 wt .-% consists of conventional formulation components. For emulsifiable concentrates, the active ingredient concentration may be about 5 to 80% by weight. Dust-form formulations usually contain 5 to 20% by weight of active ingredient, sprayable solutions about 2 to 20% by weight. For granules depends on the Part of active ingredient content depends on whether the active compound is liquid or solid and which granulation aids, fillers, etc. are used.

With the external conditions such as temperature, humidity and the like. can also vary the required application rate. It can vary within wide limits, e.g. between 0.1 g / ha and 5.0 kg / ha or more of active substance. Preferably, however, it is between 0.1 g / ha and 1, 0 kg / ha. Due to the synergistic effects between Bt vegetables and insecticide, application rates of 0.1 to 500 g / ha are particularly preferred.

For compounds of the formula (I), application rates of 10 to 500 g / ha are preferred, 10 to 200 g / ha being particularly preferred.

The active compounds according to the invention can be present in their commercially available formulations and in the use forms prepared from these formulations in mixtures with other active ingredients, such as insecticides, attractants, sterilants, acaricides, nematicides, fungicides, growth-regulating substances or herbicides.

Particularly favorable mixing partners are e.g. the following:

fungicides:

Inhibitors of nucleic acid synthesis

Benalaxyl, benalaxyl-M, bupirimate, chiralaxyl, clozylacon, dimethirimol, ethirimol, furalaxyl, hymexazole, metalaxyl, metalaxyl-M, ofurace, oxadixyl, oxolinic acid

Inhibitors of mitosis and cell division

Benomyl, Carbendazim, Diethofencarb, Fuberidazole, Pencycuron, Thiabendazole, Thiophanate-methyl, Zoxamide

Inhibitors of the respiratory chain complex I

Difiumetorim

Respiratory chain complex II inhibitors

Boscalid, Carboxin, Fenfuram, Flutolanil, Furametpyr, Mepronil, Oxycarboxin, Penthiopyrad, Thifluzamide

Inhibitors of the respiratory chain complex HI Azoxystrobin, Cyazofamide, Dimoxystrobin, Enestrobin, Famoxadone, Fenamidon, Fluoxastrobin, Kresoximmethyl, Metominostrobin, Orysastrobin, Pyraclostrobin, Picoxystrobin, Trifloxystrobin

decoupler

Dinocap, fluazinam

Inhibitors of ATP production

Fentin acetate, fentin chloride, fentin hydroxide, silthiofam

Inhibitors of amino acid and protein biosynthesis

Andoprim, blasticidin-S, cyprodinil, kasugamycin, kasugamycin hydrochloride hydrate, mepanipyrim, pyrimethanil

Inhibitors of signal transduction

Fenpiclonil, fludioxonil, quinoxyfen

Inhibitors of fat and membrane synthesis

Chlozolinate, iprodione, procymidone, vinclozolin

Ampropylfos, Potassium Ampropylfos, Edifenphos, Iprobenfos (IBP), Isoprothiolane, Pyrazophos

Tolclofos-methyl, biphenyl

Iodocarb, Propamocarb, Propamocarb hydrochloride

Inhibitors of ergosterol biosynthesis

fenhexamid,

Azaconazole, bitertanol, bromuconazole, cyproconazole, diclobutrazole, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, furconazole, furconazole-cis, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, paclobutrazole, penconazole, Propiconazole, prothioconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, Triticonazole, uniconazole, voriconazole, imazalil, imazalil sulfate, oxpoconazole, fenarimol, flurprimidol, nuarimol, pyrifenox, triforin, pefurazoate, prochloraz, triflumizole, viniconazole,

Aldimoφh, dodemorph, dodemorph acetate, fenpropimoφh, tridemorph, fenpropidin, spiroxamine,

Naftifine, pyributicarb, terbinafine

Inhibitors of cell wall synthesis

Benthiavalicarb, Bialaphos, Dimethomorph, Flumoφh, Iprovalicarb, Polyoxins, Polyoxorim, Validamycin A

Inhibitors of melanin biosynthesis

Capropamide, diclocymet, fenoxanil, phtalid, pyroquilone, tricyclazole

induction of resistance

Acibenzolar-S-methyl, probenazole, tiadinil

Multisite

Captafol, captan, chlorothalonil, copper salts such as: copper hydroxide, copper naphthenate, copper oxychloride, copper sulfate, copper oxide, oxine-copper and bordeaux mixture, dichlofluanid, dithianon, dodin, dodine free base, ferbam, folpet, fluorofolpet, guazatine, guazatin acetate, aminoactadine, aminoacidinalbesilate, nininoctadin triacetate, mancopper, mancozeb, maneb, metiram, metiram zinc, propineb, sulfur and sulfur preparations containing calcium polysulphide, thiram, tolylfluanid, zineb, ziram

Unknown mechanism

Amibromdole, benthiazole, bethoxazine, capsimycin, carvone, quinomethionate, chloropicrin, cufraneb, cyflufenamid, cymoxanil, dazomet, debacarb, diclomezine, dichlorophen, dicloran, difenzoquat, difenzoquat methylsulphate, diphenylamine, ethaboxam, ferimzone, flumetover, flusulfamide, fluopicolide, fluoroimide, hexachlorobenzene , 8-hydroxyquinoline sulfate, immamycin, methasulphocarb, metrafenone, methyl isothiocyanate, mildiomycin, natamycin, nickel dimethyldithiocarbamate, nitrothal-isopropyl, octhilinone, oxamocarb, oxyfenthiine, Pentachlorophenol and salts, 2-phenylphenol and salts, piperaline, propanosine sodium, proquinazide, pyrrolnitrin, quintozene, tecloftalam, tecnazene, triazoxide, trichlamide, zarilamide and 2,3,5,6-tetrachloro-4- (methylsulfonyl) -pyridine, N- (4-chloro-2-nitrophenyl) -N-ethyl-4-methyl-benzenesulfonamide, 2-amino-4-methyl-N-phenyl-5-thiazolecarboxamide, 2-chloro-N- (2,3-dihydro - 1, 1, 3-trimethyl-1H-inden-4-yl) -3-pyridinecarboxamide, 3- [5- (4-chlorophenyl) -2,3-dimethylisoxazolidin-3-yl] pyridine, cis-1 (4-chloro-phenyl) -2- (1H-l, 2,4-triazol-1-yl) -cycloheptanol, 2,4-dihydro-5-methoxy-2-methyl-4 - [[[[l- [3 - (trifluoromethyl) phenyl] ethylidene] amino] oxy] methyl] phenyl] -3H-l, 2,3-triazol-3-one (185336-79-2), methyl 1- (2 ₅ 3-dihydro-2,2-dimethyl-1H-inden-1-yl) -1H-imidazole-5-carboxylate, 3,4,5-trichloro-2,6-pyridinedicarbonitrile, methyl 2- [[[cyclopropyl [( 4-methoxyphenyl) imino] methyl] thio] methyl] -. Alpha.

(methoxymethylene) - benzoacetate, 4-chloro-alpha-propynyloxy-N- [2- [3-methoxy-4- (2-propynyloxy) phenyl] ethyl] -benzacetamide, (2S) -N- [2- [4- [[3- (4-chlorophenyl) -2-propynyl] oxy] -3-methoxyphenyl] ethyl] -3-methyl-2 - [(methylsulfonyl) amino] butanamide, 5-chloro-7- (4-methylpiperidine) 1-yl) -6- (2,4,6-trifluorophenyl) [l, 2,4] triazolo [l, 5-a] pyrimidine, 5-chloro-6- (2,4,6-trifluorophenyl) -N - [(1R) -1,2,2-trimethylpropyl] -

[l, 2,4] triazolo [l, 5-a] pyrimidin-7-amine, 5-chloro-N - [(lR) -l, 2-dimethylpropyl] -6- (2,4,6-trifluorophenyl) [1,2,4] triazolo [1,5-a] pyrimidin-7-amine, N- [1- (5-bromo-3-chloropyridin-2-yl) ethyl] -2,4-dichloronicotinamide, N- (5-bromo-3-chloropyridin-2-yl) methyl-2,4-dichloro-nicotinamide, 2-butoxy-6-iodo-3-propyl-benzopyranon-4-one, N - {(Z) - [( cyclopropylmethoxy) imino] [6- (difluoromethoxy) -2,3-difluoro-phenyl] methyl} -2-benzoacetamide, N- (3-ethylS, 3S-trimethylcyclohexy) -S -formylamino-hydroxybenzamide , 2 - [[[[l-

[3 (1-fluoro-2-phenylethyl) oxy] phenyl] ethylidene] amino] oxy] methyl] -alpha

(methoxyimino) -N-methyl-alpha-E-benzoacetamide, N- {2- [3-chloro-5-

(trifluoromethyl) pyridin-2-yl] ethyl} -2- (trifluoromethyl) benzamide, N- (3 ', 4'-dichloro-5-fluorobiphenyl-2-yl) -3- (difluoro-methyl) -1-methyl-1H pyrazole-4-carboxamide, N- (6-

Methoxy-3-pyridinyl) -cyclopropane carboxamide, 1 - [(4-methoxyphenoxy) methyl] -2,2-dimethylpropyl-1H-imidazole-1-carboxylic acid, O- [1 - [(4-methoxyphenoxy) methyl] - 2,2-dimethylpropyl] -1H-imidazole-1-carbothioic acid, 2- (2 - {[6- (3-chloro-2-methylphenoxy) -5-fluoropyrimidin-4-yl] oxy} phenyl) -2- (methoxyinτino) -N-methylacetaniid bactericides:

Bronopol, dichlorophen, nitrapyrin, nickel-dimethyldithiocarbamate, kasugamycin, octhilinone, furancarboxylic acid, oxytetracycline, probenazole, streptomycin, tecloftalam, copper sulfate and other copper preparations.

Insecticides / acaricides / nematicides:

Acetylcholinesterase (AChE) inhibitors

Carbamates, for example alanycarb, aldicarb, aldoxycarb, allyxycarb, aminocarb, bendodi carb, benfuracarb, bufencarb, butacarb, butocarboxime, butoxycarboxim, carbarnyl, carbofuran, carbosulfan, cloethocarb, dimetilane, ethiofencarb, fenobutarb, fenothiocarb, formetanates, Furathiocarb, isoprocarb, metam-sodium, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, promecarb, propoxur, thiodicarb, thiofanox, trimethacarb, XMC, xylylcarb, triazamates

Organophosphates, for example acephates, azamethiphos, azinphos (-methyl, -ethyl), bromophosethyl, bromfenvinfos (-methyl), butathiofos, cadusafos, carbophenothione, chloroethoxyfos, chlorfenvinphos, chlormephos, chloφyrifos (-methyl / -ethyl), coumaphos, Cyanofenphos, cyanophos, chlorfenvinphos, demeton-S-methyl, demeton-S-methylsulphone, dialifos, diazinon, dichlofenthione,

Dichlorvos / DDVP, dicrotophos, dimethoates, dimethylvinphos, dioxabenzofos, disulfonot, EPN, ethion, ethoprophos, etrimfos, famphur, fenamiphos, fenitrothion, fensulfothion, fenthion, flupyrazofos, fonofos, formothion, fosmethilane, fosthiazate, heptenophos, iodofenofen, ipprobenfos, Isazofos, Isofenphos, Isopropyl O-Salicylates, Isoxathione, Malatbione, Mecarbam, Methacrifos, Methamidophos, Methidathione, Mevinphos, Monocrotophos, Naled, Omethoate, Oxydemeton-methyl, Parathion (-methyl / -ethyl), Phenthoate, Phorate, Phosalone, Phosmet, Phosphamidone, phosphocarb, phoxim, pirimiphos (-methyl / -ethyl), profenofos, propaphos, propetamphos, prothiofos, prothoates, pyraclofos, pyridaphenthion, pyridathion, quinalphos, sebufos, sulfotep, sulprofos, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometone, triazophos , Triclorfone, vamidothione

Sodium Channel Modulators / Voltage-Dependent Sodium Channel Blockers Pyrethroids, for example, acrinathrin, allethrin (d-cis-trans, d-trans), beta-cyfluthrin, biferthrin, bioallethrin, bioallethrin-S-cyclopentyl isomer, bioethanomethrin, biopermethrin, bioresmethrin, chlovaporthrin, cis-cyclopenthrin , Cis-resmethrin, cis-permethrin, clocthrin, cycloprothrin, cyfluthrin, cyhalothrin, cyclopenthrin (alpha, beta, theta, zeta), cyphenothrin, deltamethrin, empenthrin (IR isomer), esfenvalerate, etofenprox, fenfluthrin , Fenpropathrin, fenpyrithrine, fenvalerate, flubrocythrinates, flucythrinates, flufenprox, flumethrin, fluvalinate, fubfenprox, gamma-cyhalothrin, imiprothrine, kadethrin, lambda-cyhalothrin, metofluthrin, permethrin (cis-, trans-), phenothrin (lR-trans isomer ), Prallethrin, profuthrin, protrifenbute, pyresmethrin, resmethrin, RU 15525, silafluofen, tau-fluvalinate, tefluthrin, terallethrin, tetramethrin (-1R-isomer), tralomethrin, transfluthrin, ZXI 8901, pyrethrins (pyrethrum)

DDT

Oxadiazines, for example Indoxacarb

Semicarbazone, for example metaflumizone (BAS3201)

Acetylcholine receptor agonists / antagonists

Chloronicotinyls, for example acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram,

Nithiazines, thiacloprid, thiamethoxam

Nicotine, Bensultap, Cartap

Acetylcholine receptor modulators

Spinosyn, for example spinosad

GABA-driven chloride channel antagonists Organochlorines, for example camphechlor, chlordane, endosulfan, gamma-HCH, HCH, heptachlor, lindane, methoxychlor

Fiproles, for example, acetoprole, ethiprole, fipronil, pyrafluprole, pyriprole, vaniliprole

Chloride channel activators

Mectins, for example Abamectin, Emamectin, Emamectin benzoate, Iveπnectin,

Lepimectin, milbemycin

Juvenile hormone mimetics, for example, diofenolan, epofenonans, fenoxycarb, hydroprene, kinoprene,

Methoprene, pyriproxifen, triprene

Ecdysone agonists / disruptors

Diacylhydrazines, for example chromafenozide, Halofenozide, Methoxyfenozide, Tebufenozide

Inhibitors of chitin biosynthesis

Benzoylureas, for example bistrifluron, chlorofluazuron, diflubenzuron, fluazuron, flucuroxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluron, teflubenzuron, triflumuron

buprofezin

cyromazine

Inhibitors of oxidative phosphorylation, ATP disruptors

diafenthiuron

Organotin compounds, for example azocyclotin, cyhexatin, fenbutatin oxides

Decoupling of oxidative phosphorylation by interruption of the H proton gradient Pyrroles, for example Chlorfenapyr

Dinitrophenols, for example binapacyrl, dinobutone, dinocap, DNOC, meptyldinocap

Side-I electron transport inhibitors

METI's, for example fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad

hydramethylnon

dicofol

Side-EI electron transport inhibitors

Rotenone

Side-HI electron transport inhibitors

Acequinocyl, Fluacrypyrim

Microbial disruptors of the insect membrane

Bacillus thuringiensis strains

Inhibitors of fat synthesis

tetronic acids,

for example spirodiclofen, spiromesifen,

tetramic,

for example cis-3- (2,5-dimethylphenyl) -4-hydroxy-8-methoxy-1-azaspiro [4.5] dec-3-en-2-one

carboxamides

for example flonicamide Octopaminergic agonists,

for example Amitraz

Inhibitors of magnesium-stimulated ATPase,

propargite

Nereistoxin Analog,

for example, thiocyclam hydrogen oxalate, thiosultap-sodium

Agonists of the ryanodine receptor,

benzoic acid dicarboxamides,

for example, Flubendiamid

anthranilamides,

for example, rynaxypyr (3-bromo-N- {4-chloro-2-methyl-6-

[(methylamino) carbonyl] phenyl} -1- (3-chloropyridin-2-yl) -1H-pyrazole-5-carboxamide)

Biologics, hormones or pheromones

Azadirachtin, bacillus spec, beauveria spec, codlemone, metarrhicon spec, paecilomyces spec, thuringiensin, verticillium spec.

Active substances with unknown or non-specific mechanisms of action

Fumigants, for example aluminum phosphides, methyl bromides, sulfuryl fluorides

Food inhibitors, for example Cryolite, Flonicamid, Pymetrozine

Mite growth inhibitors, for example clofentezine, etoxazole, hexythiazox

Amidoflumet, benclothiazole, benzoximate, bifenazate, bromopropylate, buprofezine, quinomethionate, chlordimeform, chlorobenzilate, chloropicrin, CIo- thiazoben, cycloprene, cyflumetofen, dicyclanil, fenoxacrim, fentrifanil, flumbenimine, flufenerim, flutenzine, gossyplasty, hydramethylnone, japonilurane, metoxadiazone, petroleum, piperonyl butoxide, potassium oleate, pyrilyl, sufluramid, tetradifon, tetrasul, triarathene, verbutin

A mixture with other known active ingredients, such as herbicides, fertilizers, growth regulators, safeners, semiochemicals, or with agents for improving the plant properties is possible.

The active ingredient content of the use forms prepared from the commercially available formulations may range from 0.00000001 to 95% by weight, preferably between 0.00001 and 1% by weight of active ingredient.

Table 1: Plant: maize

Affected structure or expressed principle Characteristic of the plant / tolerance

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

Triazole pyrimidines, pyrimidyloxybenzoates,

phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acid,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isooxazoles such as isoxaflutole or isoxachlorotol,

Trione like mesotrione or sulcotrione

Phospbinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3,5-dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protoporphyrinogen oxidase (PROTOX) diphenyl ether, cyclic imide,

Phenylpyrazole, pyridine derivative,

Phenopylate, oxadiazole, etc.

Cytochrome P450 e.g. P450 SUl Xenobiotics and herbicides like

sulfonylurea

Dimboa biosynthesis (BxI gene) Helminthosporium turcicum,

Rhopalosiphum maydis, Diplodia maydis, Ostrinia nubilalis, Lepidoptera sp.

CMiπ (small basic peptide building block plant pathogens, for example Fusarium, Alternaria, from corn kernel) Sclerotina

Com-SAFP (Zeamatin) plant pathogens, e.g. Fusarium,

Altemaria, Sclerotina, Rhizoctonia,

Chaetomium, Phycomycen

HmI gene Cochliobulus Affected structure or expressed principle Characteristic of the plant / tolerance

Chitinases Plant pathogens

Glucanases Plant pathogens

Envelope proteins viruses such as the corn dwarfing virus

(MDMV)

Toxins of Bacillus thuringiensis, VTP 3, Lepidoptera, Coleoptera, Diptera,

Bacillus cereus toxin, photorabdus and nematodes, e.g. Ostrinia nubilalis,

Toxins of Xenorhabdus Heliothis zea, armyworms e.g.

Spodoptera frugiperda, corn rootworm,

Sesamia sp., Aprotis ipsilon, Asian corn borer, weevil

3- Hydroxysteroid oxidase Lepidoptera, Coleoptera, Diptera, Nematodes, e.g. Ostrinia nubilalis, Heliothis zea,

Armyworms e.g. Spodoptera frugiperda,

Western corn rootworm, Sesamia sp., Aprotis ipsilon,

Asian corn borer, weevil

Peroxidase Lepidoptera, Coleoptera, Diptera, Nematodes, e.g. Ostrinia nubilalis, Heliothis zea,

Armyworms e.g. Spodoptera frugiperda,

Western corn rootworm, Sesamia sp., Aprotis ipsilon,

Asian corn borer, weevil

Aminopeptidase inhibitors e.g. Leucine Lepidoptera, Coleoptera, Diptera,

Aminopeptidase Inhibitors (LAPI) Nematodes, e.g. Ostrinia nubilalis,

Heliothis zea, armyworms e.g. Spodoptera frugiperda, corn rootworm, Sesamia sp.,

Aprotis ipsilon, Asian corn borer,

weevil

Lime synthase corn rootworm

Lectin Lepidoptera, Coleoptera, Diptera, Nematodes, e.g. Ostrinia nubilalis, Heliothis zea,

Armyworms e.g. Spodoptera frugiperda,

Western corn rootworm, Sesamia sp., Aprotis ipsilon,

Asian corn borer, weevil

Protease inhibitors eg cystatin, patatin, weevil, corn rootworm Affected structure or expressed principle Characteristic of the plant / tolerance

Virgiferin, CPTI Ribosome Inactivating Protein Lepidoptera, Coleoptera, Diptera, Nematodes, e.g. Ostrinia nubilalis, Heliotbis zea, armyworms e.g. Spodoptera frugiperda,

Western corn rootworm, Sesamia sp., Aprotis ipsilon,

Asian corn tosser, weevil

5C9 maize polypeptide Lepidoptera, Coleoptera, Diptera, Nematodes, e.g. Ostrinia nubilalis, Heliotbis zea, armyworms e.g. Spodoptera frugiperda,

Western corn rootworm, Sesamia sp., Aprotis ipsilon,

Asian corn tosser, weevil

HMG-CoA reductase Lepidoptera, Coleoptera, Diptera, Nematodes, e.g. Ostrinia nubilalis, Heliothis zea, armyworms e.g. Spodoptera frugiperda,

Western corn rootworm, Sesamia sp., Aprotis ipsilon,

Asian corn tosser, weevil

Plant: wheat

Affected structure / expressed protein characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

Triazole pyrimidines, pyrimidyloxybenzoates,

phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlorotol, triones such as mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis Affected structure / expressed protein characteristic of the plant / tolerance to

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3,5-dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protoporphyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides, phenylpyrazoles,

Pyridine derivatives, phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL Xenobiotics and herbicides such as

SulfonylhamstoffVerbindungen

Antifungal polypeptide AIyAFP Plant pathogens, e.g. Septoria and Fusarium

Glucose oxidase plant pathogens, e.g. Fusarium, Septoria

Pyrrolidine Synthesis Genes Plant pathogens, e.g. Fusarium, Septoria

Serine / threonine kinases Plant pathogens, e.g. Fusarium, Septoria and other diseases

Polypeptide having the activity, an over-plant pathogen, e.g. Fusarium, Septoria and sensitivity reactions trigger other diseases

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Chitinases Plant pathogens

Glucanases Plant pathogens

Double stranded ribonuclease viruses such as BYDV and MSMV

Envelope proteins viruses such as BYDV and MSMV

Toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, Coleoptera, Diptera,

Bacillus cereus toxins, photorabdus and nematodes

Toxins of Xenorhabdus

3-hydroxysteroid oxidase Lepidoptera, Coleoptera, Diptera,

nematodes

Peroxidase Lepidoptera, Coleoptera, Diptera,

nematodes

Aminopeptidase inhibitors, e.g. Leucine Lepidoptera, Coleoptera, Diptera,

Aminopeptidase inhibitor nematodes

Lectin Lepidoptera, Coleoptera, Diptera, Affected structure / expressed protein characteristic of the plant / tolerance to

Nematodes, aphids

Protease inhibitors, e.g. Cystatin, Patatin, Lepidoptera, Coleoptera, Diptera,

Virgiferin, CPTI nematodes, aphids

Ribosome inactivating protein Lepidoptera, Coleoptera, Diptera,

Nematodes, aphids

HMG-CoA reductase Lepidoptera, Coleoptera, Diptera,

Nematodes, e.g. Ostrinia nubilalis,

Heliothis zea, armyworms e.g. Spodoptera frugiperda, corn rootworm, Sesamia sp.,

Aprotis ipsilon, Asian corn borer,

weevil

Plant: barley

Affected structure / expressed protein characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlorotol, triones such as mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3, 5-Dihalo-4-hydroxybenzonitrile as

Bromoxynil and Loxinyl

5-enolpyravyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate Affected structure / expressed protein characteristic of the plant / tolerance to

Protoporphyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides,

Phenylpyrazoles, pyridine derivatives,

Phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL Xenobiotics and herbicides such as

sulfonylurea

Antifungal polypeptide AIyAFP Plant pathogens, e.g. Septoria and Fusarium

Glucose oxidase plant pathogens, e.g. Fusarium, Septoria

Pyrrolidine Synthesis Genes Plant pathogens, e.g. Fusarium, Septoria

Serine / threonine kinases Plant pathogens, e.g. Fusarium, Septoria and other diseases

Polypeptide having the activity, a plant pathogen, e.g. Fusarium, Septoria and

Hypersensitivity reaction trigger other diseases

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Chitinases Plant pathogens

Glucanases Plant pathogens

Double stranded ribonuclease viruses such as BYDV and MSMV

Envelope proteins viruses such as BYDV and MSMV

Toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, Coleoptera, Diptera,

Bacillus cereus toxins, Photorabdus xmd nematodes

Toxins of Xenorhabdus

3-hydroxysteroid oxidase Lepidoptera, Coleoptera, Diptera,

nematodes

Peroxidase Lepidoptera, Coleoptera, Diptera,

nematodes

Aminopeptidase inhibitors, e.g. Leucine Lepidoptera, Coleoptera, Diptera,

Aminopeptidase inhibitor nematodes

Lectin Lepidoptera, Coleoptera, Diptera,

Nematodes, aphids

Protease inhibitors, e.g. Cystatin, Patatin, Lepidoptera, Coleoptera, Diptera,

Virgiferin, CPTI nematodes, aphids

Ribosome inactivating protein Lepidoptera, Coleoptera, Diptera,

Nematodes, aphids

HMG-CoA reductase Lepidoptera, Coleoptera, Diptera, Affected structure / expressed protein characteristic of the plant / tolerance to

Nematodes, aphids

Plant: rice

Affected structure / expressed principle Characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylliamide compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlortol, Trione like

Mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3,5-dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protoporphyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides,

Phenylpyrazoles, pyridine derivatives,

Phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL Xenobiotics and herbicides such as

sulfonylurea

Antifungal polypeptide AIyAFP plant pathogens

Glucose oxidase plant pathogens

Pyrrolnitrin Synthesis Genes Plant pathogens

Serine / Threonine Kinases Plant Pathogens

Phenylalanine ammonia lyase (PAL) Plant pathogens, eg bacterial Affected structure / expressed principle Characteristic of the plant / tolerance to

Leaf mildew and inducible rice tan

Phytoalexins plant pathogens, e.g. bacterial

Leaf mildew and rice tan

B-1,3-glucanase (antisense) plant pathogens, e.g. bacterial

Leaf mildew and rice tan

Receptor kinase Plant pathogens, e.g. bacterial

Leaf mildew and rice tan

Polypeptide with effect, a plant pathogen

Cause hypersensitivity reaction

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Chitinases Plant pathogens, e.g. bacterial

Leaf mildew and rice tan

Glucanases Plant pathogens

Double stranded ribonuclease viruses such as BYDV and MSMV

Envelope proteins viruses such as BYDV and MSMV

Toxins of Bacillus thuringiensis, VTP 3, Lepidoptera, e.g. Stem Drill, Coleoptera,

Bacillus cereus toxins, photorabdus and e.g. Weevils like Lissorhoptrus oryzophilus,

Toxins of Xenorhabdus Diptera, rice cicadas, e.g. braunrückige

planthopper

3-hydroxysteroid oxidase Lepidoptera, e.g. Stem drills, Coleoptera, e.g. Weevils like Lissorhoptrus oryzophilus,

Diptera, rice cicadas, e.g. braunrückige

planthopper

Peroxidase Lepidoptera, e.g. Stem drills, Coleoptera, e.g. Weevils like Lissorhoptrus oryzophilus,

Diptera, rice cicadas, e.g. braunrückige

planthopper

Aminopeptidase inhibitors, e.g. Leucine Lepidoptera, e.g. Stem Drill, Coleoptera,

Aminopeptidase inhibitor e.g. Weevils such as Lissorhoptrus oryzophilus, Diptera, rice cicadas, e.g. brown-backed rice leafhopper

Lectin Lepidoptera, eg, borer, Coleoptera, Affected structure / expressed principle Characteristic of the plant / tolerance to eg weevils such as Lissorhoptrus oryzophilus, Diptera, rice cicadas, eg brown-backed rice leafhopper

Protease inhibitors, Lepidoptera, e.g. Stem drills, Coleoptera, e.g. Weevils like Lissorhoptrus oryzophilus,

Diptera, rice cicadas e.g. braunrückige

planthopper

Ribosome inactivating protein Lepidoptera, e.g. Stem drills, Coleoptera, e.g. Weevils such as Lissorhoptrus oryzophilus, Diptera, rice cicadas, e.g. brown-backed rice leafhopper

HMG-CoA reductase Lepidoptera, e.g. Stem drills, Coleoptera, e.g. Weevils such as Lissorhoptrus oryzophilus, Diptera, rice cicadas e.g. brown-backed rice leafhopper

Plant: soybean

Affected structure / expressed principle Characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlortol, Trione like

Mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown Affected structure / expressed principle Characteristic of the plant / tolerance to

Nitrilase 3,5-dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protopoφhyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides,

Phenylpyrazoles, pyridine derivatives,

Phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL or selection of xenobiotics and herbicides such as

sulfonylurea

Antifungal polypeptide AIyAFP Bacterial and fungal pathogens such as

Fusarium, sclerotinia, white stalk

Oxalate Oxidase Bacterial and fungal pathogens such as

Fusarium, sclerotinia, white stalk

Glucose Oxidase Bacterial and fungal pathogens such as

Fusarium, sclerotinia, white stalk

Pyrrolnitrin Synthesis Genes Bacterial and fungal pathogens such as

Fusarium, sclerotinia, white stalk

Serine / Threonine Kinases Bacterial and fungal pathogens such as

Fusarium, sclerotinia, white stalk

Phenylalanine Ammonia Lyase (PAL) Bacterial and fungal pathogens such as

Fusarium, sclerotinia, white stalk

Phytoalexins plant pathogens, e.g. bacterial leaf mildew and rice tan

B-1, 3-glucanase (antisense) plant pathogens, e.g. bacterial leaf mildew and rice tan

Receptor kinase Bacterial and fungal pathogens such as

Fusarium, sclerotinia, white stalk

Polypeptide having the effect of being an over-plant pathogen

Sensitivity reaction to trigger

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Chitinases Bacterial and fungal pathogens such as

Fusarium, sclerotinia, white stalk

Glucanases Bacterial and fungal pathogens such as Affected structure / expressed principle Characteristic of the plant / tolerance to

Fusarium, sclerotinia, white stalk

Double stranded ribonuclease viruses such as BPMV and SbMV

Envelope proteins viruses such as BYDV and MSMV

Toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, Coleoptera, aphids

Bacillus cereus toxins, Photorabdus and

Toxins of Xenorhabdus

3- Hydroxysteroid oxidase Lepidoptera, Coleoptera, aphids

Peroxidase Lepidoptera, Coleoptera, aphids

Aminopeptidase inhibitors, e.g. Leucine lepidoptera, coleoptera, aphids

Aminopeptidase inhibitor

Lectin Lepidoptera, Coleoptera, Aphids

Protease inhibitors, e.g. Virgif erin Lepidoptera, Coleoptera, aphids

Ribosome inactivating protein Lepidoptera, Coleoptera, aphids

HMG-CoA reductase Lepidoptera, Coleoptera, aphids

Barnase nematodes, e.g. Root nodule nematodes and

cyst nematode

Slip-trigger factor for cyst nematode cyst nematodes

Principles for preventing nematodes, e.g. Root-knot nematodes and ingestion of cyst nematodes

Plant: potato

Affected structure / expressed protein characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlortol, Trione like

Mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos Affected structure / expressed protein characteristic of the plant / tolerance to

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3,5-dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protoporphyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides,

Phenylpyrazoles, pyridine derivatives,

Phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL or selection of xenobiotics and herbicides such as

sulfonylurea

Polyphenol oxidase or polyphenol oxidase black spot

(Antisense)

Metallothionein Bacterial and fungal pathogens such as

Phytophthora

Ribonuclease Phytophthora, Verticillium, Rhizoctonia

Antifungal polypeptide AIyAFP Bacterial and fungal pathogens such as

Phytophthora

Oxalate Oxidase Bacterial and fungal pathogens such as

Phytophthora, Verticillium, Rhizoctonia

Glucose Oxidase Bacterial and fungal pathogens such as

Phytophthora, Verticillium, Rhizoctonia

Pyrrolnitrin Synthesis Genes Bacterial and fungal pathogens such as

Phytophthora, Verticillium, Rhizoctonia

Serine / Threonine Kinases Bacterial and fungal pathogens such as

Phytophthora, Verticillium, Rhizoctonia

Cecropin B bacteria such as Corynebacterium sepedonicum, Erwinia carotovora

Phenylalanine Ammonia Lyase (PAL) Bacterial and fungal pathogens such as

Phytophthora, Verticillium, Rhizoctonia

Phytoalexins Bacterial and fungal pathogens such as

Phytophthora, Verticillium, Rhizoctonia Affected structure / expressed protein characteristic of the plant / tolerance to

B-l, 3-glucanase (antisense) Bacterial and fungal pathogens such as

Phytophthora, Verticillium, Rhizoctonia

Receptor kinase Bacterial and fungal pathogens such as

Phytophthora, Verticillium, Rhizoctonia

Polypeptide with the effect of causing an over bacterial and fungal pathogens such as sensitivity reaction Phytophtora, Verticillium, Rhizoctonia

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Chitinases Bacterial and fungal pathogens such as

Phytophthora, Verticillium, Rhizoctonia

Barnase Bacterial and fungal pathogens such as

Phytophthora, Verticillium, Rhizoctonia

Gene 49 for controlling resistance to bacterial and fungal pathogens such as

Diseases Phytophthora, Verticillium, Rhizoctonia

Trans-aldolase (antisense) black-triangle

Glucanases Bacterial and fungal pathogens such as

Phytophthora, Verticillium, Rhizoctonia

Double-stranded ribonuclease viruses such as PLRV, PVY and TRV

Envelope proteins viruses such as PLRV, PVY and TRV

17 kDa or 60 kDa protein viruses such as PLRV, PVY and TRV

Inclusion proteins of the nucleus e.g. a or b viruses such as PLRV, PVY and TRV

Pseudoubiquitin viruses such as PLRV, PVY and TRV

Replicase viruses such as PLRV, PVY and TRV

Toxins of Bacillus thuringiensis, VIP 3, Coleoptera, e.g. Colorado beetle, aphids

Bacillus cereus toxins, Photorabdus and

Toxins of Xenorhabdus

3-hydroxysteroid oxidase Coleoptera, e.g. Colorado beetle, aphids

Peroxidase Coleoptera, e.g. Colorado beetle, aphids

Aminopeptidase inhibitors, e.g. Leucine Coleoptera, e.g. Colorado beetle, aphids

Aminopeptidase inhibitor

Stilbene synthase Coleoptera, e.g. Colorado beetle, aphids

Lectins Coleoptera, e.g. Colorado beetle, aphids

Protease inhibitors, e.g. Cystatin, Patatin Coleoptera, e.g. Colorado beetle, aphids

Ribosome inactivating protein Coleoptera, e.g. Colorado beetle, aphids

HMG-CoA-Reductase Coleoptera, eg Colorado beetle, aphids Affected structure / expressed protein characteristic of the plant / tolerance to

Slip-trigger factor for cyst nematode cyst nematodes

Barnase nematodes, e.g. Root knot nematodes and

cyst nematode

Principles for preventing nematodes, e.g. Root-knot nematodes and ingestion of cyst nematodes

Plant: tomato

Affected structure / expressed principle Characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlortol, Trione like

Mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3,5-dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protoporphyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides,

Phenylpyrazoles, pyridine derivatives,

Phenopylate, oxadiazoles, etc.

Cytochrome P450 eg P450 SUL or selection of xenobiotics and herbicides such as Affected structure / expressed principle Characteristic of the plant / tolerance to

sulfonylurea

Polyphenol oxidase or polyphenol oxidase black spot

(Antisense)

Metallothionein Bacterial and fungal pathogens such as

Phytophthora

Ribonuclease Phytophthora, Verticillium, Rhizoctonia

Antifungal polypeptide AIyAFP Bacterial and fungal pathogens such as bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

Oxalate oxidase Bacterial and fungal pathogens such as bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

Glucose oxidase Bacterial and fungal pathogens such as the bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

Pyrrolnitrin Synthesis Genes Bacterial and fungal pathogens such as bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

Serine / Threonine Kinases Bacterial and fungal pathogens such as bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

Cecropin B Bacterial and fungal pathogens such as bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

Phenylalanine ammonia lyase (PAL) Bacterial and fungal pathogens such as bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

Cf genes, eg Cf 9 Cf5 Cf4 Cf2 velvet spot disease Affected structure / expressed principle Characteristic of the plant / tolerance to

Osmotin blight disease

Alpha hordothionin bacteria

Bacterial and fungal pathogens such as bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

Polygalacturonase inhibitors Bacterial and fungal pathogens such as bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

Test Control Bacterial and fungal pathogens such as bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

12 Fusarium resistance site Fusarium

Phytoalexins Bacterial and fungal pathogens such as bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

B-l, 3-glucanase (antisense) Bacterial and fungal pathogens such as the bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

Receptor kinase Bacterial and fungal pathogens such as bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

Polypeptide with the effect of inducing an over bacterial and fungal pathogen such as sensitivity reaction the bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Chitinases Bacterial and fungal pathogens such as bacterial spot disease, Fusarium, Affected structure / expressed principle Characteristic of the plant / tolerance to

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

Bamase Bacterial and fungal pathogens such as the bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

Glucanases Bacterial and fungal pathogens such as bacterial spot disease, Fusarium,

Soft rot, powdery mildew, late blight,

Velvet spot disease etc.

Double stranded ribonuclease viruses such as PLRV, PVY and ToMoV

Envelope proteins viruses such as PLRV, PVY and ToMoV

17 kDa or 60 kDa protein viruses such as PLRV, PVY and ToMoV

Inclusion proteins of the nucleus e.g. a or b viruses such as PLRV, PVY and ToMoV or

Nucleoprotein TRV

Pseudoubiquitin viruses such as PLRV, PVY and ToMoV

Replicase viruses such as PLRV, PVY and ToMoV

Toxins of Bacillus thuringiensis, VIP3, Lepidoptera e.g. Heliothis, white fly

Bacillus cereus toxins, photorabdus and aphids

Toxins of Xenorhabdus

3-hydroxysteroid oxidase Lepidoptera e.g. Heliothis, white fly,

aphids

Peroxidase Lepidoptera e.g. Heliothis, white fly,

aphids

Aminopeptidase inhibitors, e.g. Leucine Lepidoptera e.g. Heliothis, white fly,

Aminopeptidase inhibitor aphids

Lectin Lepidoptera e.g. Heliothis, white fly,

aphids

Protease inhibitors, e.g. Cystatin, patatin Lepidoptera e.g. Heliothis, white fly,

aphids

Ribosome inactivating protein Lepidoptera e.g. Heliothis, white fly,

aphids

Stilbene synthase Lepidoptera eg Heliothis, white fly, Affected structure / expressed principle Characteristic of the plant / tolerance to

aphids

HMG-CoA reductase Lepidoptera e.g. Heliothis, white fly,

aphids

Slip-trigger factor for cyst nematode cyst nematodes

Barnase nematodes, e.g. Root knot nematodes and

cyst nematode

Principles for the prevention of nematodes, e.g. Root knot nematodes and

Food intake cyst nematodes

Plant: paprika

Affected structure / expressed protein characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlortol, Trione like

Mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3,5-dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protoporphyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides, Affected structure / expressed protein characteristic of the plant / tolerance to

Phenylpyrazoles, pyridine derivatives,

Phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL or selection of xenobiotics and herbicides such as

sulfonylurea

Polyphenol oxidase or polyphenol oxidase Bacterial and fungal pathogens

(Antisense)

Metallothionein Bacterial and fungal pathogens

Ribonuclease Bacterial and fungal pathogens

Antifungal polypeptide AIyAFP Bacterial and fungal pathogens

Oxalate Oxidase Bacterial and fungal pathogens

Glucose oxidase Bacterial and fungal pathogens

Pyrrolnitrin Synthesis Genes Bacterial and fungal pathogens

Serine / threonine kinases Bacterial and fungal pathogens

Cecropin B Bacterial and fungal pathogens, rot,

Velvet spot disease, etc

Phenylalanine Ammonia Lyase (PAL) Bacterial and fungal pathogens

Cf genes, e.g. Cf 9 Ct5 Cf4 Cf2 Bacterial and fungal pathogens

Osmotin Bacterial and fungal pathogens

Alpha Hordothionin Bacterial and fungal pathogens

System in Bacterial and Fungal Pathogens

Polygalacturonase inhibitors Bacterial and fungal pathogens

Prf control gene Bacterial and fungal pathogens

12 Fusarium resistance site Fusarium

Phytoalexins Bacterial and fungal pathogens

B-l, 3-glucanase (antisense) Bacterial and fungal pathogens

Receptor kinase Bacterial and fungal pathogens

Polypeptide with the effect of triggering an over bacterial and fungal pathogen sensitivity reaction

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Chitinases Bacterial and fungal pathogens

Barnase Bacterial and fungal pathogens

Glucanases Bacterial and fungal pathogens

Double-stranded ribonuclease viruses such as CMV, TEV

Envelope proteins viruses such as CMV, TEV Affected structure / expressed protein characteristic of the plant / tolerance to

17 kDa or 60 kDa protein viruses such as CMV, TEV

Inclusion proteins of the nucleus e.g. a or b viruses such as CMV, TEV or

nucleoprotein

Pseudoubiquitin viruses such as CMV, TEV

Replicase viruses such as CMV, TEV

Bacillus thuringiensis toxins, VTP 3, Lepidoptera, white fly, aphids

Bacillus cereus toxins, Photorabdus and

Toxins of Xenorhabdus

3- Hydroxysteroid oxidase Lepidoptera, white fly, aphids

Peroxidase Lepidoptera, white fly, aphids

Aminopeptidase inhibitors, e.g. Leucin lepidoptera, white fly, aphids

Aminopeptidase inhibitor

Lectin Lepidoptera, white fly, aphids

Protease inhibitors, e.g. Cystatin, Patatin Lepidoptera, white fly, aphids

Ribosome inactivating protein Lepidoptera, white fly, aphids

Stilbene synthase Lepidoptera, white fly, aphids

HMG-CoA reductase Lepidoptera, white fly, aphids

Slip-trigger factor for cyst nematode cyst nematodes

Barnase nematodes, e.g. Root knot nematodes and

cyst nematode

Principles for preventing nematodes, e.g. Root-knot nematodes and ingestion of cyst nematodes

Plant: wine

Affected structure / expressed principle Characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlortol, Trione like Affected structure / expressed principle Characteristic of the plant / tolerance to

Mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3, 5 -dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protoporphyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides,

Phenylpyrazoles, pyridine derivatives,

Phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL or selection of xenobiotics and herbicides such as

sulfonylurea

Polyphenol oxidase or polyphenol oxidase Bacterial and fungal pathogens such as

(Antisense) Botrytis and powdery mildew

Metallothionein Bacterial and fungal pathogens such as

Botrytis and powdery mildew

Ribonuclease Bacterial and fungal pathogens like

Botrytis and powdery mildew

Fungal Fighting Polypeptide AIyAFP Bacterial and fungal pathogens such as

Botrytis and powdery mildew

Oxalate Oxidase Bacterial and fungal pathogens such as

Botrytis and powdery mildew

Glucose oxidase Bacterial and fungal pathogens like

Botrytis and powdery mildew

Pyrrolnitrin Synthesis Genes Bacterial and fungal pathogens such as

Botrytis and powdery mildew

Serine / Threonine Kinases Bacterial and fungal pathogens such as

Botrytis and powdery mildew

Cecropin B Bacterial and fungal pathogens like Affected structure / expressed principle Characteristic of the plant / tolerance to

Botrytis and powdery mildew

Phenylalanine Ammonia Lyase (PAL) Bacterial and fungal pathogens such as

Botrytis and powdery mildew

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 Bacterial and fungal pathogens such as

Botrytis and powdery mildew

Osmotin Bacterial and fungal pathogens like

Botrytis and powdery mildew

Alpha Hordothionin Bacterial and fungal pathogens like

Botrytis and powdery mildew

System in Bacterial and Fungal Pathogens

Botrytis and powdery mildew

Polygalacturonase Inhibitors Bacterial and fungal pathogens such as

Botrytis and powdery mildew

Prf control gene Bacterial and fungal pathogens like

Botrytis and powdery mildew

Phytoalexins Bacterial and fungal pathogens such as

Botrytis and powdery mildew

B-l, 3-glucanase (antisense) Bacterial and fungal pathogens such as

Botrytis and powdery mildew

Receptor kinase Bacterial and fungal pathogens such as

Botrytis and powdery mildew

Polypeptide with the effect of causing overbacterial and fungal pathogens such as botrytis and sensitivity reaction to cause powdery mildew

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Chitinases Bacterial and fungal pathogens like

Botrytis and powdery mildew

Barnase Bacterial and fungal pathogens like

Botrytis and powdery mildew

Glucanases Bacterial and fungal pathogens such as botrytis and powdery mildew

Double-stranded ribonuclease viruses

Envelope proteins viruses

17kDa or 60 kDa protein viruses Affected structure / expressed principle Characteristic of the plant / tolerance to

Inclusion proteins of the nucleus e.g. a or b viruses or

nucleoprotein

Pseudoubiquitin viruses

Replicase viruses

Toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids

Bacillus cereus toxins, Photorabdus and

Toxins of Xenorhabdus

3- Hydroxysteroid oxidase Lepidoptera, aphids

Peroxidase Lepidoptera, aphids

Aminopeptidase inhibitors, e.g. Leucine lepidoptera, aphids

Aminopeptidase inhibitor

Lectin Lepidoptera, aphids

Protease inhibitors, e.g. Cystatin, Patatin Lepidoptera, aphids

Ribosome inactivating protein Lepidoptera, aphids

Stilbene synthase Lepidoptera, aphids, diseases

HMG-CoA reductase Lepidoptera, aphids

Slip-trigger factor for cyst nematode cyst nematodes

Barnase nematodes, e.g. Root knot nematodes and

Cyst nematodes or common diseases

CBI root-knot nematodes

Principles for preventing nematodes, e.g. Root-knot nematode uptake or root-cyst nematode

Plant: oilseed rape

Affected structure / expressed protein characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlortol, Trione like Affected structure / expressed protein characteristic of the plant / tolerance to

Mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3,5-dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protoporphyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides,

Phenylpyrazoles, pyridine derivatives,

Phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL or selection of xenobiotics and herbicides such as

sulfonylurea

Polyphenol oxidase or polyphenol Bacterial and fungal pathogens such as

Oxidase (antisense) Cylindrosporium, Phoma, Sclerotinia

Metallothionein Bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

Ribonuclease Bacterial and fungal pathogens like

Cylindrosporium, Phoma, Sclerotinia

Fungal Fighting Polypeptide AIyAFP Bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

Oxalate Oxidase Bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

Glucose oxidase Bacterial and fungal pathogens like

Cylindrosporium, Phoma, Sclerotinia

Pyrrolnitrin Synthesis Genes Bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

S erin / threonine kinases Bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

Cecropin B Bacterial and fungal pathogens like Affected structure / expressed protein characteristic of the plant / tolerance to

Cylindrosporium, Phoma, Sclerotinia

Phenylalanine Ammonia Lyase (PAL) Bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

Cf genes, e.g. Cf 9 Cf5 Cf4 CG Bacterial and fungal pathogens like

Cylindrosporium, Phoma, Sclerotinia

Osmotin Bacterial and fungal pathogens like

Cylindrosporium, Phoma, Sclerotinia

Alpha Hordothionin Bacterial and fungal pathogens like

Cylindrosporium, Phoma, Sclerotinia

System in Bacterial and Fungal Pathogens

Cylindrosporium, Phoma, Sclerotinia

Polygalacturonase Inhibitors Bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

Prf control gene Bacterial and fungal pathogens like

Cylindrosporium, Phoma, Sclerotinia

Phytoalexins Bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

B-l, 3-glucanase (antisense) Bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

Receptor kinase Bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

Polypeptide with the effect of inducing an over-bacterial and fungal pathogens such as sensitivity reaction Cylindrosporium, Phoma, Sclerotinia

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Chitinases Bacterial and fungal pathogens like

Cylindrosporium, Phoma, Sclerotinia

Barnase Bacterial and fungal pathogens like

Cylindrosporium, Phoma, Sclerotinia,

nematodes

Glucanases Bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

Double-stranded ribonuclease viruses

Envelope proteins viruses

17kDa or 60 kDa protein viruses Affected structure / expressed protein characteristic of the plant / tolerance to

Inclusion proteins of the nucleus e.g. a or b viruses or

nucleoprotein

Pseudoubiquitin viruses

Replicase viruses

Toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids

Bacillus cereus toxins, Photorabdus and

Toxins of Xenorhabdus

3- Hydroxysteroid oxidase Lepidoptera, aphids

Peroxidase Lepidoptera, aphids

Aminopeptidase inhibitors, e.g. Leucine lepidoptera, aphids

Aπünopeptidase inhibitor

Lectin Lepidoptera, aphids

Protease inhibitors, e.g. Cystatin, patatin, lepidoptera, aphids

CPTI

Ribosome inactivating protein Lepidoptera, aphids

Stilbene synthase Lepidoptera, aphids, diseases

HMG-CoA reductase Lepidoptera, aphids

Slip-trigger factor for cyst nematode cyst nematodes

Barnase nematodes, e.g. Root knot nematodes and

cyst nematode

CBI root-knot nematodes

Principles for the prevention of food nematodes, e.g. Root knot nematodes and took root cyst nematodes induced at nematode feeding sites

Plant: Brassica vegetables (cabbage, sprouts etc ..)

Affected structure / expressed protein characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione Affected structure / expressed protein characteristic of the plant / tolerance to

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlortol, Trione like

Mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3,5-dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protopoφhyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides,

Phenylpyrazoles, pyridine derivatives,

Phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL or selection of xenobiotics and herbicides such as

Sulfonylhamstoffverbindungen

Polyphenol oxidase or polyphenol oxidase Bacterial and fungal pathogens

(Antisense)

Metallothionein Bacterial and fungal pathogens

Ribonuclease Bacterial and fungal pathogens

Antifungal polypeptide AIyAFP Bacterial and fungal pathogens

Oxalate Oxidase Bacterial and fungal pathogens

Glucose oxidase Bacterial and fungal pathogens

Pyrrolnitrin Synthesis Genes Bacterial and fungal pathogens

Serine / threonine kinases Bacterial and fungal pathogens

Cecropin B Bacterial and fungal pathogens

Phenylalanine Ammonia Lyase (PAL) Bacterial and fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 Bacterial and fungal pathogens

Osmotin Bacterial and fungal pathogens

Alpha Hordothionin Bacterial and fungal pathogens

System in Bacterial and Fungal Pathogens Affected structure / expressed protein characteristic of the plant / tolerance to

Polygalacturonase inhibitors Bacterial and fungal pathogens

Prf control gene Bacterial and fungal pathogens

Phytoalexins Bacterial and fungal pathogens

B-l, 3-glucanase (antisense) Bacterial and fungal pathogens

Receptor kinase Bacterial and fungal pathogens

Polypeptide with the effect of triggering an over bacterial and fungal pathogen sensitivity reaction

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Chitinases Bacterial and fungal pathogens

Barnase Bacterial and fungal pathogens

Glucanases Bacterial and fungal pathogens

Double-stranded ribonuclease viruses

Envelope proteins viruses

17kDa or 60 kDa protein viruses

Inclusion proteins of the nucleus e.g. a or b viruses or

nucleoprotein

Pseudoubiquitin viruses

Replicase viruses

Toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids

Bacillus cereus toxins, Photorabdus and

Toxins of Xenorhabdus

3- Hydroxysteroid oxidase Lepidoptera, aphids

Peroxidase Lepidoptera, aphids

Aminopeptidase inhibitors, e.g. Leucine lepidoptera, aphids

Aminopeptidase inhibitor

Lectin Lepidoptera, aphids

Protease inhibitors, e.g. Cystatin, patatin, lepidoptera, aphids

CPTI

Ribosome inactivating protein Lepidoptera, aphids

Stilbene synthase Lepidoptera, aphids, diseases

HMG-CoA reductase Lepidoptera, aphids

Slip-trigger factor for cyst nematode cyst nematodes

Barnase nematodes, eg root knot nematodes and Affected structure / expressed protein characteristic of the plant / tolerance to

cyst nematode

CBI root-knot nematodes

Principles for preventing nematodes, e.g. Root-knot nematodes and ingestions that are induced at nematode-feeding sites root-cyst nematodes Cyst nematodes

Plants: pome fruit e.g. Apples, pears

Affected structure / expressed protein characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlortol, Trione like

Mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3,5-dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protoporphyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides,

Phenylpyrazoles, pyridine derivatives,

Phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL or selection of xenobiotics and herbicides such as

sulfonylurea Affected structure / expressed protein characteristic of the plant / tolerance to

Polyphenol oxidase or polyphenol oxidase Bacterial and fungal pathogens such as

(Antisense) Camp scab on apples or fire blight

Metallothionein Bacterial and fungal pathogens such as

Camp scab on apples or fire blight

Ribonuclease Bacterial and fungal pathogens like

Camp scab on apples or fire blight

Fungal Fighting Polypeptide AIyAFP Bacterial and fungal pathogens such as

Camp scab on apples or fire blight

Oxalate Oxidase Bacterial and fungal pathogens such as

Camp scab on apples or fire blight

Glucose oxidase Bacterial and fungal pathogens like

Camp scab on apples or fire blight

Pyrrolnitrin Synthesis Genes Bacterial and fungal pathogens such as

Camp scab on apples or fire blight

Serine / Threonine Kinases Bacterial and fungal pathogens such as

Camp scab on apples or fire blight

Cecropin B Bacterial and fungal pathogens like

Camp scab on apples or fire blight

Phenylalanine Ammonia Lyase (PAL) Bacterial and fungal pathogens such as

Camp scab on apples or fire blight

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 Bacterial and fungal pathogens such as

Camp scab on apples or fire blight

Osmotin Bacterial and fungal pathogens like

Camp scab on apples or fire blight

Alpha Hordothionin Bacterial and fungal pathogens like

Camp scab on apples or fire blight

System in Bacterial and Fungal Pathogens

Camp scab on apples or fire blight

Polygalacturonase Inhibitors Bacterial and fungal pathogens such as

Camp scab on apples or fire blight

Prf control gene Bacterial and fungal pathogens like

Camp scab on apples or fire blight

Phytoalexins Bacterial and fungal pathogens such as

Camp scab on apples or fire blight

Bl, 3-glucanase (antisense) Bacterial and fungal pathogens such as Affected structure / expressed protein characteristic of the plant / tolerance to

Camp scab on apples or fire blight

Receptor kinase Bacterial and fungal pathogens such as

Camp scab on apples or fire blight

Polypeptide with the effect of causing an over bacterial and fungal pathogens such as storage sensitivity reaction scab on apples or fire blight

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) Pathogenic lytic-acting protein Bacterial and fungal pathogens such as

Camp scab on apples or fire blight

Lysozyme Bacterial and fungal pathogens such as

Camp scab on apples or fire blight

Chitinases Bacterial and fungal pathogens like

Camp scab on apples or fire blight

Barnase Bacterial and fungal pathogens like

Camp scab on apples or fire blight

Glucanases Bacterial and fungal pathogens such as

Camp scab on apples or fire blight

Double-stranded ribonuclease viruses

Envelope proteins viruses

17kDa or 60 kDa protein viruses

Inclusion proteins of the nucleus e.g. a or b viruses or

nucleoprotein

Pseudoubiquitin viruses

Replicase viruses

Toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids, mites

Bacillus cereus toxins, Photorabdus and

Toxins of Xenorhabdus

3- Hydroxysteroid oxidase Lepidoptera, aphids, mites

Peroxidase Lepidoptera, aphids, mites

Aminopeptidase inhibitors, e.g. Leucine lepidoptera, aphids, mites

Aminopeptidase inhibitor

Lectin Lepidoptera, aphids, mites

Protease inhibitors, e.g. Cystatin, patatin, lepidoptera, aphids, mites

CPTI Affected structure / expressed protein characteristic of the plant / tolerance to

Ribosome inactivating protein Lepidoptera, aphids, mites

Stilbene synthase Lepidoptera, aphids, diseases, mites

HMG-CoA reductase Lepidoptera, aphids, mites

Slip-trigger factor for cyst nematode cyst nematodes

Barnase nematodes, e.g. Root knot nematodes and

cyst nematode

CBI root-knot nematodes

Principles for preventing nematodes, e.g. Root-knot nematodes and ingestions induced at nematode feeding sites root-cyst nematodes

Plant: melon

Affected structure / expressed protein characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlortol, Trione like

Mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3,5-dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protopoφhyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides, Affected structure / expressed protein characteristic of the plant / tolerance to

Phenylpyrazoles, pyridine derivatives,

Phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL or selection of xenobiotics and herbicides such as

Sulfonylharnstoffverbüidungen

Polyphenol oxidase or polyphenol oxidase Bacterial or fungal pathogens such as

(Antisense) Phytophthora

Metallothionein Bacterial or fungal pathogens such as

Phytophthora

Ribonuclease Bacterial or fungal pathogens such as

Phytophthora

Antifungal polypeptide AIyAFP Bacterial or fungal pathogens such as

Phytophthora

Oxalate Oxidase Bacterial or fungal pathogens such as

Phytophthora

Glucose oxidase Bacterial or fungal pathogens like

Phytophthora

Pyrrolnitrin Synthesis Genes Bacterial or fungal pathogens such as

Phytophthora

Serine / Tbxeonin Kinases Bacterial or fungal pathogens such as

Phytophthora

Cecropin B Bacterial or fungal pathogens like

Phytophthora

Phenylalanine Ammonia Lyase (PAL) Bacterial or fungal pathogens such as

Phytophthora

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 Bacterial or fungal pathogens such as

Phytophthora

Osmotin Bacterial or fungal pathogens like

Phytophthora

Alpha Hordothionin Bacterial or fungal pathogens like

Phytophthora

System in Bacterial or fungal pathogens like

Phytophthora

Polygalacturonase inhibitors Bacterial or fungal pathogens such as

Phytophthora

Prf control gene Bacterial or fungal pathogens such as Affected structure / expressed protein characteristic of the plant / tolerance to

Phytophthora

Phytoalexins Bacterial or fungal pathogens like

Phytophthora

B-l, 3-glucanase (antisense) Bacterial or fungal pathogens such as

Phytophthora

Receptor kinase Bacterial or fungal pathogens such as

Phytophthora

Polypeptide with the effect of causing an over bacterial or fungal pathogens such as sensitivity to Phytophthora

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Lytic-acting protein Bacterial or fungal pathogens like

Phytophthora

Lysozyme Bacterial or fungal pathogens like

Phytophthora

Chitinases Bacterial or fungal pathogens like

Phytophthora

Barnase Bacterial or fungal pathogens like

Phytophthora

Glucanases Bacterial or fungal pathogens such as

Phytophthora

Double-stranded ribonuclease viruses such as CMV, PRSV, WMV2, SMV,

ZYMV

Envelope proteins viruses such as CMV, PRSV, WMV2, SMV,

ZYMV

17kDa or 60 kDa protein viruses like CMV, PRSV, WMV2, SMV,

ZYMV

Inclusion proteins of the nucleus e.g. a or b viruses like CMV, PRSV, WMV2, SMV, or

Nucleoprotein ZYMV

Pseudoubiquitin viruses such as CMV, PRSV, WMV2, SMV,

ZYMV

Replicase viruses like CMV, PRSV, WMV2, SMV,

ZYMV

Toxins of Bacillus thuringiensis, VDP 3, Lepidoptera, aphids, mites Affected structure / expressed protein characteristic of the plant / tolerance to

Bacillus cereus toxins, Photorabdus and

Toxins of Xenorhabdus

3- Hydroxysteroid oxidase Lepidoptera, aphids, mites, white fly

Peroxidase Lepidoptera, aphids, mites, white fly

Aminopeptidase inhibitors, e.g. Leucine lepidoptera, aphids, mites, white fly

Aminopeptidase inhibitor

Lectin Lepidoptera, aphids, mites, white fly

Protease inhibitors, e.g. Cystatin, patatin, lepidoptera, aphids, mites, white fly

CPTI, Virgiferin

Ribosome inactivating protein Lepidoptera, aphids, mites, white fly

Stilbene synthase Lepidoptera, aphids, mites, white fly

HMG-CoA reductase Lepidoptera, aphids, mites, white fly

Slip-trigger factor for cyst nematode cyst nematodes

Barnase nematodes, e.g. Root knot nematodes and

cyst nematode

CBI root-knot nematodes

Principles for preventing nematodes, e.g. Root-knot nematodes and ingestions induced at nematode feeding sites root-cyst nematodes

Plant: banana

Affected structure / expressed protein characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlortol, Trione like

Mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content Affected structure / expressed protein characteristic of the plant / tolerance to

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3,5-dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protoporphyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides,

Phenylpyrazoles, pyridine derivatives,

Phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL or selection of xenobiotics and herbicides such as

sulfonylurea

Polyphenol oxidase or polyphenol oxidase Bacterial or fungal pathogens

(Antisense)

Metallothionein Bacterial or fungal pathogens

Ribonuclease Bacterial or fungal pathogens

Antifungal polypeptide AIyAFP Bacterial or fungal pathogens

Oxalate Oxidase Bacterial or fungal pathogens

Glucose oxidase Bacterial or fungal pathogens

Pyrrolnitrin Synthesis Genes Bacterial or fungal pathogens

Serine / threonine kinases Bacterial or fungal pathogens

Cecropin B Bacterial or fungal pathogens

Phenylalanine Ammonia Lyase (PAL) Bacterial or fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 Bacterial or fungal pathogens

Osmotin Bacterial or fungal pathogens

Alpha Hordothionin Bacterial or fungal pathogens

System in Bacterial or Fungal Pathogens

Polygalacturonase inhibitors Bacterial or fungal pathogens

Prf control gene Bacterial or fungal pathogens

Phytoalexins Bacterial or fungal pathogens

B-l, 3-glucanase (antisense) Bacterial or fungal pathogens

Receptor kinase Bacterial or fungal pathogens Affected structure / expressed protein characteristic of the plant / tolerance to

Polypeptide with the effect of triggering an Uber- bacterial or fungal pathogen sensitivity reaction

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Lyric Protein Bacterial or fungal pathogens

Lysozyme Bacterial or fungal pathogens

Chitinases Bacterial or fungal pathogens

Barnase Bacterial or fungal pathogens

Glucanases Bacterial or fungal pathogens

Double stranded ribonuclease viruses such as the Banana Bunchy Top Virus

(BBTV)

Envelope proteins viruses such as the Banana Bunchy Top Virus

(BBTV)

17kDa or 60kDa protein viruses like the Banana Bunchy Top Virus

(BBTV)

Inclusion proteins of the nucleus e.g. a or b viruses like the Banana Bunchy Top virus or

Nucleoprotein (BBTV)

Pseudoubiquitin viruses like the Banana Bunchy Top Virus

(BBTV)

Replicase viruses like the Banana Bunchy Top Virus

(BBTV)

Toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids, mites, nematodes

Bacillus cereus toxins, Photorabdus and

Toxins of Xenorhabdus

3- Hydroxysteroid oxidase Lepidoptera, aphids, mites, nematodes

Peroxidase Lepidoptera, aphids, mites, nematodes

Aminopeptidase inhibitors, e.g. Leucine lepidoptera, aphids, mites, nematodes

Aminopeptidase inhibitor

Lectin Lepidoptera, aphids, mites, nematodes

Protease inhibitors, e.g. Cystatin, patatin, lepidoptera, aphids, mites, nematodes

CPTI, Virgiferin

Ribosome inactivating protein Lepidoptera, aphids, mites, nematodes

Stilbene synthase Lepidoptera, aphids, mites, nematodes

HMG-CoA reductase Lepidoptera, aphids, mites, nematodes Affected structure / expressed protein characteristic of the plant / tolerance to

Slip-trigger factor for cyst nematode cyst nematodes

Barnase nematodes, e.g. Root knot nematodes and

cyst nematode

CBI root-knot nematodes

Principles for preventing nematodes, e.g. Root-knot nematodes and ingestions induced at nematode feeding sites root-cyst nematodes

Plant: cotton

Affected structure / expressed protein characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlortol, Trione like

Mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3,5-dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protopoφhyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides,

Phenylpyrazoles, pyridine derivatives, Phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL or selection of xenobiotics and herbicides such as sulfonylurea compounds

Polyphenol oxidase or polyphenol oxidase Bacterial or fungal pathogens

(Antisense)

Metallothionein Bacterial or fungal pathogens

Ribonuclease Bacterial or fungal pathogens

Anti-fungal polypeptide AIyAFP Bacterial or fungal pathogens

Oxalate oxidase Bacterial or fungal pathogens

Glucose oxidase Bacterial or fungal pathogens

Pyrrolnitrin Synthesis Genes Bacterial or fungal pathogens

Serine / threonine kinases Bacterial or fungal pathogens

Cecropin B Bacterial or fungal pathogens

Phenylalanine Ammonia Lyase (PAL) Bacterial or fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 Bacterial or fungal pathogens

Osmotin Bacterial or fungal pathogens

Alpha Hordothionin Bacterial or fungal pathogens

System in Bacterial or Fungal Pathogens

Polygalacturonase inhibitors Bacterial or fungal pathogens

Prf control gene Bacterial or fungal pathogens

Phytoalexins Bacterial or fungal pathogens

B-l, 3-glucanase (antisense) Bacterial or fungal pathogens

Receptor kinase Bacterial or fungal pathogens

Polypeptide with the effect of triggering an over-bacterial or fungal • pathogen sensitivity reaction

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Lytic-acting protein Bacterial or fungal pathogens

Lysozyme Bacterial or fungal pathogens

Chitinases Bacterial or fungal pathogens

Barnase Bacterial or fungal pathogens

Glucanases Bacterial or fungal pathogens

Double stranded ribonuclease viruses such as the wound tumor virus (WTV)

Envelope proteins viruses such as wound tumor virus (WTV)

17kDa or 60 kDa protein viruses such as wound tumor virus (WTV)

Inclusion proteins of the nucleus eg a or b viruses like the wound tumor virus (WTV) or

nucleoprotein

Pseudoubiquitin viruses such as wound tumor virus (WTV)

Replicase viruses like wound tumor virus (WTV)

Toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids, mites, nematodes,

Bacillus cereus toxins, photorabdus and white fly

Toxins of Xenorhabdus

3- Hydroxysteroid oxidase Lepidoptera, aphids, mites, nematodes, white fly

Peroxidase Lepidoptera, aphids, mites, nematodes, white fly

Aminopeptidase inhibitors, e.g. Leucine lepidoptera, aphids, mites, nematodes,

Aminopeptidase inhibitor white fly

Lectin Lepidoptera, aphids, mites, nematodes, white fly

Protease inhibitors, e.g. Cystatin, patatin, lepidoptera, aphids, mites, nematodes, CPTI, virgiferin white fly ribosome-inactivating protein Lepidoptera, aphids, mites, nematodes, white fly

Stilbene synthase Lepidoptera, aphids, mites, nematodes, white fly HMG-CoA reductase Lepidoptera, aphids, mites, nematodes, white fly

Slip triggering factor for cyst nematodes Cyst nematodes Barnase Nematodes, e.g. Root knot nematodes and

cyst nematode

CBI root-knot nematodes

Principles for preventing nematodes, e.g. Root-knot nematodes and ingestions induced at nematode feeding sites root-cyst nematodes

Plant: sugarcane

Affected characteristic / expressed protein characteristic of the plant / tolerance Affected characteristic / expressed protein characteristic of the plant / tolerance

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlortol, Trione like

Mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3,5-dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protoporphyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides,

Phenylpyrazoles, pyridine derivatives,

Phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL or selection of xenobiotics and herbicides such as

sulfonylurea

Polyphenol oxidase or polyphenol oxidase Bacterial or fungal pathogens

(Antisense)

Metallothionein Bacterial or fungal pathogens

Ribonuclease Bacterial or fungal pathogens

Antifungal polypeptide AIyAFP Bacterial or fungal pathogens

Oxalate Oxidase Bacterial or fungal pathogens

Glucose oxidase Bacterial or fungal pathogens

Pyrrolnitrin Synthesis Genes Bacterial or fungal pathogens

Serine / threonine kinases Bacterial or fungal pathogens

Cecropin B Bacterial or fungal pathogens Affected characteristic / expressed protein characteristic of the plant / tolerance

Phenylalanine Ammonia Lyase (PAL) Bacterial or fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 Bacterial or fungal pathogens

Osmotin Bacterial or fungal pathogens

Alpha Hordothionin Bacterial or fungal pathogens

System in Bacterial or Fungal Pathogens

Polygalacturonase inhibitors Bacterial or fungal pathogens

Prf control gene Bacterial or fungal pathogens

Phytoalexins Bacterial or fungal pathogens

B-l, 3-glucanase (antisense) Bacterial or fungal pathogens

Receptor kinase Bacterial or fungal pathogens

Polypeptide with the effect of triggering an over-bacterial or fungal pathogen sensitivity reaction

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Lytic-acting protein Bacterial or fungal pathogens

Lysozyme Bacterial or fungal pathogens, e.g.

Clavibacter

Chitinases Bacterial or fungal pathogens

Barnase Bacterial or fungal pathogens

Glucanases Bacterial or fungal pathogens

Double-stranded ribonuclease viruses such as SCMV, SrMV

Envelope proteins viruses such as SCMV, SrMV

17kDa or 60 kDa protein viruses such as SCMV, SrMV

Inclusion proteins of the nucleus e.g. a or b viruses like SCMV, SrMV or

nucleoprotein

Pseudoubiquitin viruses such as SCMV, SrMV

Replicase viruses like SCMV, SrMV

Toxins of Bacillus thuringiensis, VTP 3, Lepidoptera, aphids, mites, nematodes,

Bacillus cereus toxins, photorabdus and white fly, beetles such as e.g. the Mexican

Xenorhabdus rice borer toxins

3- Hydroxysteroid oxidase Lepidoptera, aphids, mites, nematodes, white fly, beetles e.g. the Mexican

rice borers

Peroxidase Lepidoptera, aphids, mites, nematodes, Affected characteristic / Exprüniertes protein characteristic of the plant / tolerance to white fly, beetles such as the Mexican

rice borers

Aminopeptidase inhibitors, e.g. Leucine lepidoptera, aphids, mites, nematodes,

Aminopeptidase inhibitor white fly, beetle e.g. the Mexican

rice borers

Lectin Lepidoptera, aphids, mites, nematodes, white fly, beetles e.g. the Mexican

rice borers

Protease inhibitors, e.g. Cystatin, patatin, lepidoptera, aphids, mites, nematodes,

CPTI, Virgiferin white fly, beetles such as e.g. the Mexican

rice borers

Ribosome inactivating protein Lepidoptera, aphids, mites, nematodes, white fly, beetles such as e.g. the Mexican

rice borers

Stilbene synthase Lepidoptera, aphids, mites, nematodes, white fly, beetles e.g. the Mexican

rice borers

HMG-CoA reductase Lepidoptera, aphids, mites, nematodes, white fly, beetles e.g. the Mexican

rice borers

Slip-trigger factor for cyst nematode cyst nematodes

Barnase nematodes, e.g. Root knot nematodes and

cyst nematode

CBI root-knot nematodes

Principles for preventing nematodes, e.g. Root-knot nematodes and ingestions induced at nematode feeding sites root-cyst nematodes

Plant: sunflower

Affected structure / expressed protein characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides Affected structure / expressed protein characteristic of the plant / tolerance to

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlortol, Trione like

Mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinotbxicin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of EVIP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3, 5-Dihalo-4-hydroxybenzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protoporphyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides,

Phenylpyrazoles, pyridine derivatives,

Phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL or selection of xenobiotics and herbicides such as

sulfonylurea

Polyphenol oxidase or polyphenol oxidase Bacterial or fungal pathogens

(Antisense)

Metallothionein Bacterial or fungal pathogens

Ribonuclease Bacterial or fungal pathogens

Antifungal polypeptide AIyAFP Bacterial or fungal pathogens

Oxalate Oxidase Bacterial or fungal pathogens, e.g.

Sclerotinia

Glucose oxidase Bacterial or fungal pathogens

Pyrrolnitrin Synthesis Genes Bacterial or fungal pathogens

Serine / threonine kinases Bacterial or fungal pathogens

Cecropin B Bacterial or fungal pathogens

Phenylalanine Ammonia Lyase (PAL) Bacterial or fungal pathogens

Cf genes, eg Cf 9 CfS Cf4 Cf2 Bacterial or fungal pathogens Affected structure / expressed protein characteristic of the plant / tolerance to

Osmotin Bacterial or fungal pathogens

Alpha Hordothionin Bacterial or fungal pathogens

System in Bacterial or Fungal Pathogens

Polygalacturonase inhibitors Bacterial or fungal pathogens

Prf control gene Bacterial or fungal pathogens

Phytoalexins Bacterial or fungal pathogens

B-l, 3-glucanase (antisense) Bacterial or fungal pathogens

Receptor kinase Bacterial or fungal pathogens

Polypeptide with the effect of triggering an over bacterial or fungal pathogen sensitivity reaction

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Lytic-acting protein Bacterial or fungal pathogens

Lysozyme Bacterial or fungal pathogens

Chitinases Bacterial or fungal pathogens

Barnase Bacterial or fungal pathogens

Glucanases Bacterial or fungal pathogens

Double-stranded ribonuclease viruses such as CMV, TMV

Envelope proteins viruses such as CMV, TMV

17 kDa or 60 kDa protein viruses such as CMV, TMV

Inclusion proteins of the nucleus e.g. a or b viruses like CMV, TMV or

nucleoprotein

Pseudoubiquitin viruses such as CMV, TMV

Replicase viruses like CMV, TMV

Toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids, mites, nematodes,

Bacillus cereus toxins, photorabdus and white fly, beetle

Toxins of Xenorhabdus

3- Hydroxysteroid oxidase Lepidoptera, aphids, mites, nematodes, white fly, beetle

Peroxidase Lepidoptera, aphids, mites, nematodes, white fly, beetle

Aminopeptidase inhibitors, e.g. Leucine lepidoptera, aphids, mites, nematodes,

Aminopeptidase inhibitor white fly, beetle

Lectin Lepidoptera, aphids, mites, nematodes, Affected structure / expressed protein Characteristic of the plant / tolerance to white fly, beetle

Protease inhibitors, e.g. Cystatin, patatin, lepidoptera, aphids, mites, nematodes,

CPTI, Virgiferin white fly, beetle

Ribosome inactivating protein Lepidoptera, aphids, mites, nematodes, white fly, beetle

Stilbene synthase Lepidoptera, aphids, mites, nematodes, white fly, beetle

HMG-CoA reductase Lepidoptera, aphids, mites, nematodes, white fly, beetle

Slip-trigger factor for cyst nematode cyst nematodes

Barnase nematodes, e.g. Root knot nematodes and

cyst nematode

CBI root-knot nematodes

Principles for the prevention of dietary nematodes, eg, root-knot nematodes and ingestions induced at nematode feeding sites, root-cyst nematodes

Plants: sugar beet, turnips

Affected structure / expressed protein characteristic of the plant / tolerance to

Acetolactate synthase (ALS) sulfonylurea compounds, imidazolinones

triazolopyrimidines,

Pyrimidyloxybenzoates, phthalides

Acetyl-CoA-carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids,

cyclohexanedione

Hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as isoxaflutole or

Isoxachlortol, Trione like

Mesotrione or sulcotrione

Phosphinothricin acetyltransferase phosphinothricin

O-methyltransferase Modified lignin content

Glutamine synthetase glufosinate, bialaphos

Adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis

Adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Anthranilate synthase inhibitors of tryptophan synthesis and of

cleardown

Nitrilase 3,5-dihalo-4-hydroxy-benzonitrile as

Bromoxynil and Loxinyl

5-enolpyruvyl-3-phosphoshikimate glyphosate or sulfosate

Synthase (EPSPS)

Glyphosate oxidoreductase glyphosate or sulfosate

Protoporphyrinogen oxidase (PROTOX) diphenyl ether, cyclic imides,

Phenylpyrazoles, pyridine derivatives,

Phenopylate, oxadiazoles, etc.

Cytochrome P450 e.g. P450 SUL or selection of xenobiotics and herbicides such as

sulfonylurea

Polyphenol oxidase or polyphenol oxidase Bacterial or fungal pathogens

(Antisense)

Metallothionein Bacterial or fungal pathogens

Ribonuclease Bacterial or fungal pathogens

Antifungal polypeptide AIyAFP Bacterial or fungal pathogens

Oxalate Oxidase Bacterial or fungal pathogens, e.g.

Sclerotinia

Glucose oxidase Bacterial or fungal pathogens Affected structure / expressed protein characteristic of the plant / tolerance to

Pyrrolnitrin Synthesis Genes Bacterial or fungal pathogens

Serine / threonine kinases Bacterial or fungal pathogens

Cecropin B Bacterial or fungal pathogens

Affected structure / expressed principle Characteristic of the plant / tolerance

Phenylalanine Ammonia Lyase (PAL) Bacterial or fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 Bacterial or fungal pathogens

Osmotin Bacterial or fungal pathogens

Alpha Hordothionin Bacterial or fungal pathogens

System in bacterial or fungal pathogens

Polygalacturonase inhibitors Bacterial or fungal pathogens

Prf control gene Bacterial or fungal pathogens

Phytoalexins Bacterial or fungal pathogens

B-l, 3-glucanase (antisense) Bacterial or fungal pathogens

AX + WIN proteins Bacterial and fungal pathogens such as

Cercospora beticola

Receptor kinase Bacterial or fungal pathogens

Polypeptide with the effect of triggering an over-bacterial or fungal pathogen sensitivity reaction

Genes of the systemic acquired viral, bacterial fungal and nematode

Resistance (SAR) pathogens

Lytic-acting protein Bacterial or fungal pathogens

Lysozyme Bacterial or fungal pathogens

Chitinases Bacterial or fungal pathogens

Barnase Bacterial or fungal pathogens

Glucanases Bacterial or fungal pathogens

Double stranded ribonuclease viruses such as BNYW

Envelope proteins viruses such as BNYW

17 kDa or 60 kDa protein viruses such as BNYW

Inclusion proteins of the nucleus e.g. a or b viruses such as BNYW or

nucleoprotein

Pseudoubiquitin viruses such as BNYW

Replicase viruses such as BNYW

Toxins of Bacillus thuringiensis, ^" VTP 3, Lepidoptera, aphids, mites, nematodes,

Bacillus cereus toxins, photorabdus and white fly, beetles, root flies Affected structure / expressed protein characteristic of the plant / tolerance to

Toxins of Xenorhabdus

3- Hydroxysteroid oxidase Lepidoptera, aphids, mites, nematodes, white fly, beetle, root fly

Peroxidase Lepidoptera, aphids, mites, nematodes, white fly, beetle, root fly

Aminopeptidase inhibitors, e.g. Leucine lepidoptera, aphids, mites, nematodes,

Aminopeptidase inhibitor white fly, beetle, root fly

Lectin Lepidoptera, aphids, mites, nematodes, white fly, beetle, root fly

Protease inhibitors, e.g. Cystatin, patatin, lepidoptera, aphids, mites, nematodes,

CPTI, Virgiferin white fly, beetle, root fly

Ribosome inactivating protein Lepidoptera, aphids, mites, nematodes, white fly, beetle, root fly

Stilbene synthase Lepidoptera, aphids, mites, nematodes, white fly, beetle, root fly

HMG-CoA reductase Lepidoptera, aphids, mites, nematodes, white fly, beetle, root fly

Slip-trigger factor for cyst nematode cyst nematodes

Barnase nematodes, e.g. Root knot nematodes and

cyst nematode

Resistance site for cyst nematodes of cyst nematodes

beets

CBI root-knot nematodes

Principles for the prevention of dietary nematodes, eg root-knot nematodes and ingestions, the food intakes induced by root-cyst nematodes Table 2

The following abbreviations were used in the table:

Active principle of the transgenic plant: AP

Photorhabdus luminescens: PL

Xenorhabdus nematophilus: XN

Proteinase inhibitors: Plnh.

Plant lectins PLec.

Agglutinines: Aggl.

3-hydroxysteroid:

HO

Cholesterol oxidase: CO

Chitinase: CH

Glucanase: GL

Stilbene synthase SS

AP control of

CrylA (a) Adoxophyes spp.

CrylA (a) Agrotis spp.

CrylA (a) Alabama argiliaceae

CrylA (a) Anticarsia gemmatalis

CrylA (a) Chilo spp.

CrylA (a) Clysia ambiguella

CrylA (a) Crocidolomia binotalis

CrylA (a) Cydia spp.

CrylA (a) Diparopsis castanea

CrylA (a) Earias spp.

CrylA (a) Ephestia spp.

CrylA (a) Heliothis spp. ,

CrylA (a) Heliula undalis

CrylA (a) Keiferia lycopersicella

CrylA (a) Leucoptera scitella

CrylA (a) Lithocollethis spp.

CrylA (a) Lobesia botrana

CrylA (a) Ostrinia nubilalis

CrylA (a) Pandemis spp. AP control of

CrylA (a) Pectinophora gossyp

CrylA (a) Phyllocnistis citrella

CrylA (a) Pieris spp.

CrylA (a) Plutella xylostella

CrylA (a) Sciophophaga spp.

CrylA (a) Sesamia spp.

CrylA (a) Sparganothis spp.

CrylA (a) Spodoptera spp.

CrylA (a) Tortrix spp.

CrylA (a) Trichoplusia ni

CrylA (a) Agriotes spp.

CrylA (a) Anthonomus grandis

CrylA (a) Curculio spp.

CrylA (a) Diabrotica balteata

CrylA (a) Leptinotarsa spp.

CrylA (a) Lissorhoptrus spp.

CrylA (a) Otiorhynchus spp.

CrylA (a) Aleurothrixus spp.

CrylA (a) Aleyrodes spp.

CrylA (a) Aonidiella spp.

CrylA (a) Aphididea spp.

CrylA (a) Aphis spp.

CrylA (a) Bemisia tabaci

CrylA (a) Empoasca spp.

CrylA (a) Mycus spp.

CrylA (a) Nephotettix spp.

CrylA (a) Nilaparvata spp.

CrylA (a) Pseudococcus spp.

CrylA (a) Psylla spp.

CrylA (a) Quadraspidiotus spp

CrylA (a) Schizaphis spp.

CrylA (a) Trialeurodes spp.

CrylA (a) Lyriomyza spp.

CrylA (a) Oscinella spp. AP control of

CrylA (a) Phorbia spp.

CrylA (a) Frankliniella spp.

CrylA (a) Thrips spp.

CrylA (a) Scirtothrips aurantii

CrylA (a) Aceria spp.

CrylA (a) Aculus spp.

CiylA (a) Brevipaipus spp.

CrylA (a) Panonychus spp.

CiylA (a) Phyllocoptruta spp.

CrylA (a) Tetranychus spp.

CiylA (a) Heterodera spp.

CrylA (a) Meloidogyne spp.

CrylA (b) Adoxophyes spp

CiylA (b) Agrotis spp

CrylA (b) Alabama argillaceae

CrylA (b) Anticarsia gemmatalis

CrylA (b) Chilo spp.

CrylA (b) Ciysia ambiguella

CrylA (b) Crocidolomia binotaiis

QylA (b) Cydia spp.

CrylA (b) Diparopsis castanea

CrylA (b) Earias spp.

CrylA (b) Ephestia spp.

CrylA (b) Heliothis spp.

CrylA (b) Hellula and alis

CrylA (b) Keiferia lycopersicella

CrylA (b) Leucoptera scitella

CrylA (b) Lithocollethis spp.

CrylA (b) Lobesia botrana

CrylA (b) Ostrinia nubilalis

CrylA (b) Pandemis spp.

CrylA (b) Pectinophora gossyp.

CrylA (b) Phyllocnistis citrella

CrylA (b) Pieris spp. AP control of

CrylA (b) Plutelia xyiostella

CrylA (b) Scirpophaga spp.

CrylA (b) Sesamia spp.

CrylA (b) Sparganothis spp.

CrylA (b) Spodoptera spp.

CrylA (b) Tortrix spp.

CrylA (b) Trichoplusia ni

CrylA (b) Agriotes spp.

CrylA (b) Anthonomus grandis

CrylA (b) Curculio spp.

CrylA (b) Diabrotica balteata

CrylA (b) Leptinotarsa spp.

CrylAφ) Lissorhoptrus spp.

CrylA (b) Otiorhynchus spp.

CrylA (b) Aleurothrixus spp.

CrylA (b) Aleyrodes spp.

CrylA (b) Aonidiella spp.

CrylA (b) Aphididae spp.

CrylA (b) Aphis spp.

CrylA (b) Bemisia tabaci

CrylA (b) Empoasca spp.

CrylA (b) Mycus spp.

CrylA (b) Nephotettix spp.

CrylA (b) Nilaparvata spp.

CiylA (b) Pseudococcus spp.

CrylA (b) Psylla spp.

CrylA (b) Quadraspidiotus spp

CrylA (b) Schizaphis spp.

CrylA (b) Trialeurodes spp.

CrylA (b) Lyriomyza spp.

CrylA (b) Oscinella spp.

CrylA (b) Phorbia spp.

CrylA (b) Frankliniella spp.

CrylA (b) Thrips spp. AP control of

CrylA (b) Scirtothrips aurantii

CrylA (b) Aceria spp.

CrylA (b) Aculus spp.

CrylA (b) Brevipalpus spp.

CrylA (b) Panonychus spp.

CrylA (b) Phyllocoptruta spp.

CrylA (b) Tetranychus spp.

CrylA (b) Heterodera spp.

CrylA (b) Meloidogyne spp.

CrylA (c) Adoxophyes spp.

CrylA (c) Agrotis spp.

CrylA (c) Alabama argillaceae

CrylA (c) Anticarsia gemmatalis

CrylA (c) Chilo spp.

CrylA (c) Ciysia ambiguella

CrylA (c) Crocidolomia binotalis

CrylA (c) Cydia spp.

CrylA (c) Diparopsis castanea

CrylA (c) Earias spp.

CrylA (c) Ephestia spp.

CrylA (c) Heliotbis spp.

CrylA (c) Hellula and alis

CrylA (c) Keiferia lycopersicella

CrylA (c) Leucoptera scitella

CrylA (c) Lithocollethis spp.

CrylA (c) Lobesia botrana

CrylA (c) Ostrinia nubilalis

CrylA (c) Pandemis spp.

CrylA (c) Pectinophora gossypielia.

CrylA (c) Phyllocnistis citrella

CrylA (c) Pieris spp.

CrylA (c) Plutella xyiostella

CrylA (c) Scirpophaga spp.

CrylA (c) Sesamia spp. AP control of

CrylA (c) Sparganothis spp.

CrylA (c) Spodoptera spp.

CrylA (c) Tortrix spp.

CrylA (c) Trichoplusia ni

CrylA (c) Agriotes spp.

CrylA (c) Anthonomus grandis

CrylA (c) Curculio spp.

CrylA (c) Diabrotica baiteata

CrylA (c) Leptinotarsa spp.

CrylA (c) Lissorhoptrus spp.

CrylA (c) Otiorhynchus spp.

CrylA (c) Aleurothrixus spp.

CrylA (c) Aleyrodes spp.

CrylA (c) Aonidiella spp.

CrylA (c) Aphididae spp.

CrylA (c) Aphis spp.

CrylA (c) Bemisia tabaci

CrylA (c) Empoasca spp.

CrylA (c) Mycus spp.

CrylA (c) Nephotettix spp.

CrylA (c) Nilaparvata spp.

CrylA (c) Pseudococcus spp.

CrylA (c) Psylla spp.

CrylA (c) Quadraspidiotus spp.

CrylA (c) Schizaphis spp.

CrylA (c) Trialeurodes spp.

CrylA (c) Lyriomyza spp.

CrylA (c) Oscinelia spp.

CrylA (c) Phorbia spp.

CrylA (c) Frankiiniella spp.

CrylA (c) Thrips spp.

CrylA (c) Scirtothrips aurantii

CrylA (c) Aceria spp.

CrylA (c) Aculus spp. AP control of

: rylA (c) Brevipalpus spp. CrylA (c) Panonychus spp. CrylA (c) Phyllocoptruta spp. CrylA (c) Tetranychus spp. CrylA (c) Heterodera spp. CrylA (c) Meloidogyne spp. CryllA Adoxophyes spp. CryllA Agrotis spp. CryllA Alabama argillaceae CryllA Anticarsia gemmatalis CryllA Chilo spp. CryllA Clysia ambiguella CryllA Crocidolomia binotalis CryllA Cydia spp. CryllA Diparopsis castanea CryllA Earias spp. CryllA Ephestia spp. CryllA Heliothis spp. CryllA Hellula undalis CryllA Keiferia lycopersicella CryllA Leucoptera scitella CryllA Lithocoliethis spp. CryllA Lobesia botrana CryllA Ostrinia nubilalis CryllA Pandemis spp. CryllA pectinophora gossyp. CryllA Phyllocnistis citrella CryllA Pieris spp. CryllA Plutella xylostella CryllA Sciophophaga spp. CryllA Sesamia spp. CryllA Sparganothis spp. CryllA Spodoptera spp. CryllA Tortrix spp. AP control of IryllA Trichoplusia ni CryllA Agriotes spp. iryllA Anthonomus grandis! ryllA Curculio spp. CryllA Diabrotica balteata CryllA Leptinotarsa spp. CryllA Lissorhoptrus spp. CryllA Otiorhynchus spp. CryllA Aleurothrixus spp. CryllA Aleyrodes spp. CryllA Aonidiella spp. CryllA Aphididae spp. CryllA Aphis spp. CryllA Bemisia tabaci CryllA Empoasca spp. CryllA Mycus spp. CryllA Nephotettix spp. CryllA Nilaparvata spp. CryllA Pseudococcus spp. CryllA Psyila spp. CryllA Quadraspidiotus spp. CryllA Schizaphis spp. CryllA Trialeurodes spp. CryllA Lyriomyza spp. CryllA Oscinella spp. CryllA Phorbia spp. CryllA Frankliniella spp. CryllA Thrips spp. CryllA Scirtothrips aurantii CryllA Aceria spp. CryllA Acutus spp. CryllA Brevipalpus spp. CryllA Panonychus spp. CryllA Phyllocoptruta spp. AP control of RyllA Tetranychus spp. RyllA Heterodera spp. CryllA Meloidogyne spp. CrylllA Adoxophyes spp. CrylllA Agrotis spp. CrylllA Alabama argiiiaceae CrylllA Anticarsia gemmataiis CrylllA Chilo spp. CrylllA Ciysia ambiguelia CrylllA Crocodolomia binotalis CrylllA Cydia spp. CrylllA Diparopsis castanea CrylllA Earias spp. CrylllA Ephestia spp. CrylllA Heliothis spp. CrylllA Hellula and ally CrylllA Keiferia lycopersicella CrylllA Leucoptera scitella CrylllA Lithocollethis spp. CrylllA Lobesia botrana CrylllA Ostrinia nubilalis CrylllA Pandemis spp. CrylllA Pectinophora gossyp. CrylllA Phyllocnistis citrella CrylllA Pieris spp. CrylllA Plutella xylostella CrylllA Scirpophaga spp. CrylllA Sesamia spp. CrylllA Sparganothis spp. CrylllA Spodoptera spp. CrylllA Tortrix spp. CrylllA Trichoplusia ni CrylllA Agriotes spp. CrylllA Anthonomus grandis AP control of

CrylllA Curculio spp. CrylllA Diabrotica balteata CrylllA Leptinotarsa spp. CrylllA Lissorhoptrus spp. CrylllA Otiorhynchus spp. CrylllA aleurothrixus spp. CrylllA Aleyrodes spp. CrylllA Aonidiella spp. CrylllA Aphididae spp. CrylllA Aphis spp. CrylllA Bemisia tabaci CrylllA Empoasca spp. CrylllA Mycus spp. CrylllA Nephotettix spp. CrylllA Nilaparvata spp. CrylllA Pseudococcus spp. CrylllA Psylla spp. CrylllA quadraspidiotus spp. CrylllA Schizaphis spp. CrylllA Trialeurodes spp. CrylllA Lyriomyza spp. CrylllA Oscinella spp. CrylllA Phorbia spp. CrylllA Frankliniella spp. CrylllA Thrips spp. CrylllA Scirtothrips aurantii CrylllA Aceria spp. CrylllA Aculus spp. CrylllA Brevipalpus spp. CrylllA Panonychus spp. CrylllA Phyllocoptruta spp. CrylllA Tetranychus spp. CrylllA Heterodera spp. CrylllA Meloidogyne spp. AP control of

CrylllB2 Adoxophyes spp.

CrylllB2 Agrotis spp.

CrylllB2 Alabama argiilaceae

CrylllB2 Anticarsia gemmatalis

CrylllB2 Chilo spp.

CrylllB2 Clysia ambiguella

CrylllB2 Crocidolomia binotaiis

CrylllB2 Cydia spp.

CrylllB2 Diparopsis castanea

CrylllB2 Earias spp.

CrylllB2 Ephestia spp.

CrylllB2 Heliothis spp.

CrylllB2 Hellula undalis

CrylllB2 Keiferia lycopersicella

CrylllB2 Leucoptera sectelia

CrylllB2 Lithocollethis spp.

CrylllB2 Lobesia botrana

CrylllB2 Ostrinia nubilalis

CrylllB2 Pandemis spp.

Crylim2 Pectinophora gossyp.

CrylIIB2 Phyllocnistis citrella

CrylllB2 Pieris spp.

CrylllB2 Plutella xylostella

CrylllB2 Scirpophaga spp.

CrylllB2 Sesamia spp.

CrylllB2 Sparganothis spp.

CrylllB2 Spodoptera spp.

CrylllB2 Tortrix spp.

CrylllB2 Trichoplusia ni

CrylllB2 Agriotes spp.

CrylllB2 Anthonomus grandis

CrylllB2 Curculio spp.

CrylllB2 Diabrotica balteata

CrylllB2 Leptinotarsa spp. AP control of

: rylllB2 Lissorhoptrus spp. CrylllB2 Otiorhynchus spp. CrylllB2 Aleurothrixus spp. CrylllB2 Aleyrodes spp. CrylllB2 Aonidiella spp. CrylllB2 Aphididae spp. CrylllB2 Aphis spp. CrylllB2 Bemisia tabaci CrylllB2 Empoasca spp. CrylIIB2 Mycus spp. CrylllB2 Nephotettix spp. CrylllB2 Nilaparvata spp. CrylllB2 Pseudococcus spp. CrylllB2 Psylla spp. CrylllB2 Quadraspidiotus spp. CrylllB2 Schizaphis spp. CrylllB2 Trialeurodes spp. CrylllB2 Lyriornyza spp. CrylllB2 Oscinella spp. CrylllB2 Phorbia spp. CrylllB2 Frankliniella spp. CrylllB2 Thrips spp. CrylllB2 Scirtothrips aurantii CrylllB2 Aceria spp. CrylllB2 Acutus spp. CrylllB2 Brevipalpus spp. CrylllB2 Panonychus spp. CrylllB2 Phyllocoptruta spp. CrylllB2 Tetranychus spp. CrylllB2 Heterodera spp. CrylllB2 Meloidogyne spp. CytA Adoxophyes spp. CytA Agrotis spp. CytA alabama argiilaceae AP control of

CytA Anticarsia gemmatalis

CytA Chilo spp.

CytA Clysia ambiguella

CytA Crocidolomia binotaiis

CytA Cydia spp.

CytA Diparopsis castanea

CytA Earias spp.

CytA Ephestia spp.

CytA Heliothis spp.

CytA hellula and alis

CytA Keiferia lycopersicella

CytA Leucoptera scitelia

CytA Lithocollethis spp.

CytA Lobesia botrana

CytA Ostrinia nubilalis

CytA Pandemis spp.

CytA pectinophora gossyp.

CytA Phyllocnistis citrella

CytA Pieris spp.

CytA Plutella xylostella

CytA Sciophophaga spp.

CytA sesamia spp.

CytA Sparganothis spp.

CytA Spodoptera spp.

CytA Tortrix spp.

CytA Trichoplusia ni

CytA Agriotes spp.

CytA Anthonomus grandis

CytA Curculio spp.

CytA Diabrotica balteata

CytA Leptinotarsa spp.

CytA Lissorhoptrus spp.

CytA Otiorhynchus spp.

CytA Aleurothrixus spp. AP control of

CytA Aleyrodes spp.

CytA Aonidielia spp.

CytA Aphididae spp.

CytA Aphis spp.

CytA Bemisia tabaci

CytA Empoasca spp.

CytA Mycus spp.

CytA Nephotettix spp.

CytA Nilaparvata spp.

CytA Pseudococcus spp.

CytA Psylla spp.

CytA Quadraspidiotus spp.

CytA Schizaphis spp.

CytA Trialeurodes spp.

CytA Lyriomyza spp.

CytA Oscinella spp.

CytA Phorbia spp.

CytA Frankliniella spp.

CytA Thrips spp.

CytA Scirtothrips aurantii

CytA Aceria spp.

CytA acutus spp.

CytA Brevipalpus spp.

CytA Panonychus spp.

CytA Phyllocoptruta spp.

CytA Tetranychus spp.

CytA Heterodera spp.

CytA Meloidogyne spp.

VIP3 Adoxophyes spp.

VIP3 Agrotis spp.

VIP3 Alabama argillaceae

VIP3 Anticarsia geramatalis

VIP3 Chilo spp.

VIP3 Clysia ambiguella AP control of

VIP3 Crocidolomia binotalis

VIP3 Cydia spp.

VIP3 Diparopsis castanea

VEP3 Earias spp.

VIP3 Ephestia spp.

VIP3 Heliothis spp.

VIP3 Hellula undalis

VIP3 Keiferia lycopersicella

VIP3 Leucoptera scitella

VIP3 Lithocollethis spp.

VIP3 Lobesia botrana

VIP3 Ostrinia nubilalis

VIP3 Pandemis spp.

VIP3 Pectinophora gossyp.

VIP3 Phyllocnistis citrella

V1P3 Pieris spp.

VIP3 Piutella xylostella

VIP3 Sciophophaga spp.

VIP3 Sesamia spp.

Vff3 Sparganothis spp.

VIP3 Spodoptera spp.

VIP3 Tortrix spp.

VIP3 Trichoplusia ni

VIP3 Agriotes spp.

VIP3 Anthonomus grandis

VIP3 Curculio spp.

VIP3 Diabrotica balteata

VIP3 Leptinotarsa spp.

VDP3 Lissorhoptrus spp.

VEP3 Otiorhynchus spp.

VIP3 Aleurothrixus spp.

V1P3 Aleyrodes spp.

VIP3 Aonidiella spp. AP control of

VIP3 Aphididae spp.

VIP3 Aphis spp.

VIP3 Bemisia tabaci

VIP3 Empoasca spp.

VIP3 Mycus spp.

VIP3 Nephotettix spp.

VIP3 Niiaparvata spp.

VIP3 Pseudococcus spp.

VIP3 Psylla spp.

VEP3 Quadraspidiotus spp.

VIP3 Schizaphis spp.

VIP3 Trialeurodes spp.

VIP3 Lyriomyza spp.

VIP3 Oscinella spp.

VIP3 Phorbia spp.

VIP3 Frankliniella spp.

VIP3 Thrips spp.

VIP3 Scirtothrips aurantii

VTP3 Aceria spp.

VIP3 Acutus spp.

VIP3 Brevipalpus spp.

VIP3 Panonychus spp.

VIP3 Phyllocoptruta spp.

VIP3 Tetranychus spp.

VIP3 Heterodera spp.

VIP3 Meloidogyne spp.

GL Adoxophyes spp.

GL Agrotis spp.

GL Alabama argillaceae

GL Anticarsia gemmatalis

GL Chilo spp.

GL Clysia ambiguella

GL Croidolomia binotaiis

GL Cydia spp. AP control of

GL Diparopsis castanea

GL Earias spp.

GL Ephestia spp.

GL Heliothis spp.

GL Hellula undalis

GL Keiferia lycopersicella

GL Leucoptera scitella

GL Lithocollethis spp.

GL Lobesia botrana

GL Ostrinia nubilalis

GL Pandemis spp.

GL Pectinophora gossyp.

GL Phyliocnistis citrella

GL Pieris spp.

GL Plutella xylostella

GL Scirpophaga spp.

GL Sesamia spp.

GL Sparganothis spp.

GL Spodoptera spp.

GL Tortrix spp.

GL Trichoplusia ni

GL Agriotes spp.

GL Anthonomus grandis

GL Curculio spp.

GL Diabrotica balteata

GL Leptinotarsa spp.

GL Lissorhoptrus spp.

GL Otiorhynchus spp.

GL Aleurothrixus spp.

GL Aleyrodes spp.

GL Aonidiella spp.

GL Aphididae spp.

GL Apbis spp.

GL Bemisia tabaci AP control of

GL Empoasca spp.

GL Mycus spp.

GL Nephotettix spp.

GL Nilaparvata spp.

GL Pseudococcus spp.

GL Psylia spp.

GL Quadraspidiotus spp.

GL Schizaphis spp.

GL Trialeurodes spp.

GL Lyriomyza spp.

GL Oscinella spp.

GL Phorbia spp.

GL Frankliniella spp.

GL Thrips spp.

GL Scirtothrips aurantii

GL Aceria spp.

GL Aculus spp.

GL Brevipalpus spp.

GL Panonychus spp.

GL Phyliocoptruta spp.

GL Tetranychus spp.

GL Heterodera spp.

GL Meioidogyne spp.

PL Adoxophyispp.

PL Agrotis spp.

PL Alabama argillaceae

PL Anticarsia gemmatalis

PL Cbilo spp.

PL Clysia ambiguella

PL Crocidolomia binotalis

PL Cydia spp.

PL Diparopsis castanea

PL Earias spp.

PL Ephestia spp. AP control of

PL Heliothis spp.

PL Hellula undaiis

PL Keiferia lycopersicella

PL Leucoptera scitella

PL Lithocollethis spp.

PL Lobesia botrana

PL Ostrinia nubilalis

PL Pandemis spp.

PL Pectinophora gossyp.

PL Phyllocnistis citrella

PL Pieris spp.

PL Plutella xylostella

PL Scirpophaga spp.

PL Sesamia spp.

PL Sparganothis spp.

PL Spodoptera spp.

PL Tortrix spp.

PL Trichoplusia ni

PL Agriotes spp.

PL Anthonomus grandis

PL Curculio spp.

PL Diabrotica balteata

PL Leptinotarsa spp.

PL Lissorhoptrus spp.

PL Otiorhynchus spp.

PL Aleurothrixus spp.

PL Aleyrodes spp.

PL Aonidiella spp.

PL Aphididae spp.

PL Aphis spp.

PL Bemisia tabaci

PL Empoasca spp.

PL Mycus spp.

PL Nephotettix spp. AP control of

PL Nilaparvata spp.

PL Pseudococcus spp.

PL Psylla spp.

PL Quadraspidiotus spp.

PL Schizaphis spp.

PL Trialeurodes spp.

PL Lyriomyza spp.

PL Oscinella spp.

PL Phorbia spp.

PL Franklinieila spp.

PL Thrips spp.

PL Scirtothrips auranii

PL Aceria spp.

PL Aculus spp.

PL Brevipalpus spp.

PL Panonychus spp.

PL Phyllocoptruta spp.

PL Tetranychus spp.

PL Heterodera spp.

PL Meloidogyne spp.

XN Adoxophyes spp.

XN Agrotis spp.

XN Alabama argiliaceae

XN Anticarsia gemmatalis

XN Chilo spp.

XN Clysia ambiguella

XN Crocidolomia binotalis

XN Cydia spp.

XN Diparopsis castanea

XN Earias spp.

XN Ephestia spp.

XN Heliothis spp.

XN Helluia undaiis

XN Keiferia lycopersicella AP control of

XN Leucoptera scitella

XN Lithocollethis spp.

XN Lobesia botrana

XN Ostrinia nubilalis

XN Pandemis spp.

XN Pectinophora gossyp

XN Phyllocnistis citrella

XN Pieris spp.

XN Plutella xylostella

XN Scirpophaga spp.

XN Sesamia spp.

XN Sparganothis spp.

XN Spodoptera spp.

XN Tortrix spp.

XN Trichoplusia ni

XN Agriotes spp.

XN Anthonomus grandis

XN Curculio spp.

XN Diabrotica balteata

XN Leptinotarsa spp.

XN Lissorhoptrus spp.

XN Otiorhynchus spp.

XN Aleurothrixus spp.

XN Aleyrodes spp.

XN Aonidiella spp.

XN Aphididae spp.

XN Aphis spp.

XN bemisia tabaci

XN Empoasca spp.

XN Mycus spp.

XN Nephotettix spp.

XN Nilaparvata spp.

XN Pseudococcus spp.

XN Psylla spp. AP control of

XN Quadraspidiotus spp.

XN Schizaphis spp.

XN Trialeurodes spp.

XN Lyriomyza spp.

XN Oscinella spp.

XN Phorbia spp.

XN Frankliniella spp.

XN Thrips spp.

XN Scirtothrips aurantii

XN Aceria spp.

XN Aculus spp.

XN Brevipalpus spp.

XN Panonychus spp.

XN Phyllocoptruta spp.

XN Tetranychus spp.

XN Heterodera spp.

XN Meloidogyne spp.

Plnh. Adoxophyes spp.

Plnh. Agrotis spp.

Plnh. Alabama argiliaceae

Plnh. Anticarsia gemmatalis

Plnh. Chilo spp.

Plnh. Clysia ambiguella

Plnh. Crocidolomia binotalis

Plnh. Cydia spp.

Plnh. Diparopsis castanea

Plnh. Earias spp.

Plnh. Ephestia spp.

Plnh. Heliothis spp.

Plnh. Heliuia undalis

Plnh. Keiferia lycopersicella

Plnh. Leucoptera scitella

Plnh. Lithocollethis spp. AP control of

Plnh. Lobesia botrana

Plnh. Ostrinia nubilalis

Plnh. Pandemis spp.

Plnh. Pectinophora gossyp.

Plnh. Phyllocnistis citrelia

Plnh. Pieris spp.

Plnh. Plutella xylostella

Plnh. Scirpophaga spp.

Plnh. Sesame spp.

Plnh. Sparganothis spp.

Plnh. Spodoptera spp.

Plnh. Tortrix spp.

Plnh. Trichoplusia ni

Plnh. Agriotes spp.

Plnh. Anthonomus grandis

Plnh. Curculio spp.

Plnh. Diabrotica balteata

Plnh. Leptinotarsa spp.

Plnh. Lissorhoptrus spp.

Plnh. Otiorhynchus spp.

Phih. Aleurothrixus spp.

Plnh. Aleyrodes spp.

Plnh. Aonidiella spp.

Plnh. Aphididae spp.

Plnh. Aphis spp.

Plnh. Bemisia tabaci

Plnh. Empoasca spp.

Plnh. Mycus spp.

Plnh. Nephotettix spp.

Plnh. Nilaparvata spp.

Plnh. Pseudococcus spp.

Plnh. Psylla spp.

Plnh. Quadraspidiotus spp.

Plnh. Schizaphis spp. AP control of

Plnh. Trialeurodes spp.

Plnh. Lyriomyza spp.

Plnh. Oscinella spp.

Plnh. Phorbia spp.

Phih. Frankliniella spp.

Plnh. Thrips spp.

Plnh. Scirtothrips aurantii

Plnh. Aceria spp.

Plnh. Acutus spp.

Plnh. Brevipalpus spp.

Plnh. Panonychus spp.

Plnh. Phyllocoptruta spp.

Plnh. Tetranychus spp.

Plnh. Heterodera spp.

Plnh. Meloidogyne spp.

Plec. Adoxophyes spp.

Plec. Agrotis spp.

Plec. Alabama argillaceae

Plec. Anticarsia gemmatalis

Plec. Chilo spp.

Plec. Clysia ambiguella

Plec. Crocidolomia binotalis

Plec. Cydia spp.

Plec. Diparopsis castanea

Plec. Earias spp.

Plec. Ephestia spp.

Plec. Heliothis spp.

Plec. Hellula and alis

Plec. Keiferia lycopersicella

Plec. Leucoptera scitella

Plec. Lithocollethis spp.

Plec. Lobesia botrana

Plec. Ostrinia nubilalis

Plec. Pandemis spp. AP control of

Plec. Pectinophora gossyp.

Plec. Phyllocnistis citrella

Plec. Pieris spp.

Plec. Plutella xylostella

Plec. Scirpophaga spp.

Plec. Sesame spp.

Plec. Sparganothis spp.

Plec. Spodoptera spp.

Plec. Tortrix spp.

Plec. Trichoplusia ni

Plec. Agriotes spp.

Plec. Anthonomus grandis

Plec. Curculio spp.

Plec. Diabrotica balteata

Plec. Leptinotarsa spp.

Plec. Lissorhoptrus spp.

Plec. Otiorhynchus spp.

Plec. Aleurothrixus spp.

Plec. Aleyrodes spp.

Plec. Aonidiella spp.

Plec. Aphididae spp.

Plec. Aphis spp.

Plec. Bemisia tabaci

Plec. Empoasca spp.

Plec. Mycus spp.

Plec. Nephotettix spp.

Plec. Nilaparvata spp.

Plec. Pseudococcus spp.

Plec. Psylia spp.

Plec. Quadraspidiotus spp

Plec. Schizaphis spp.

Plec. Trialeurodes spp.

Plec. Lyriomyza spp.

Plec. Oscinella spp. AP control of

Plec. Phorbia spp.

Plec. Frankliniella spp.

Plec. Thrips spp.

Plec. Scirtothnps aurantii

Plec. Aceria spp.

Plec. Aculus spp.

Plec. Brevipalpus spp.

Plec. Panonychus spp.

Plec. Phyllocoptruta spp.

Plec. Tetranychus spp.

Plec. Heterodera spp.

Plec. Meloidogyne spp.

Aggl. Adoxophyes spp.

Aggl. Agrotis spp.

Aggl. Alabama argillaceae

Aggl. Anticarsia gemmatalis

Aggl. Chilo spp.

Aggl. Clysia ambiguella

Aggl. Crocidolomia binotalis

Aggl. Cydia spp.

Aggl. Diparopsis castanea

Aggl. Earias spp.

Aggl. Ephestia spp.

Aggl. Heliothis spp.

Aggl. Hellula and alis

Aggl. Keiferia lycopersicella

Aggl. Leucoptera scitella

Aggl. Lithocollethis spp.

Aggl. Lobesia botrana

Aggl. Ostrinia nubilalis AP control of

Aggl. Pandemis spp.

Aggl. Pectinophora gossyp.

Aggl. Phyllocnistis citrella

Aggl. Pieris spp.

Aggl. Plutia xylostella

Aggl. Scirpophaga spp.

Aggl. Sesame spp.

Aggl. Sparganothis spp.

Aggl. Spodoptera spp.

Aggl. Tortrix spp.

Aggl. Trichoplusia ni

Aggl. Agriotes spp.

Aggl. Anthonomus grandis

Aggl. Curculio spp.

Aggl. Diabrotica balteata

Aggl. Leptinotarsa spp.

Aggl. Lissorhoptrus spp.

Aggl. Otiorhynchus spp.

Aggl. Aleurothrixus spp.

Aggl. Aleyrodes spp.

Aggl. Aonidiella spp.

Aggl. Aphididae spp.

Aggl. Aphis spp.

Aggl. Bemisia tabaci

Aggl. Empoasca spp.

Aggl. Mycus spp.

Aggl. Nephotettix spp.

Aggl. Nilaparvata spp.

Aggl. Pseudococcus spp.

Aggl. Psylla spp.

Aggl. Quadraspidiotus spp

Aggl. Schizaphis spp.

Aggl. Trialeurodes spp. AP control of

Aggl. Lyriomyza spp.

Aggl. Oscinella spp.

Aggl. Phorbia spp.

Aggl. Frankliniella spp.

Aggl. Thrips spp.

Aggl. Scirtothrips auranti

Aggl. Aceria spp.

Aggl. Aculus spp.

Aggl. Brevipalpus spp.

Aggl. Panonychus spp.

Aggl. Phyllocoptruta spp

Aggl. Tetranychus spp.

Aggl. Heterodera spp.

Aggl. Meloidogyne spp.

CO Adoxophyes spp.

CO Agrotis spp.

CO Alabama argiliaceae

CO anticarsia gemmatalis

CO Chilo spp.

CO Ciysia ambiguella

CO Crocidolomia binotalis

CO Cydia spp.

CO Diparopsis castanea

CO Earias spp.

CO Ephestia spp.

CO Heliothis spp.

CO hellula and alis

CO Keiferia lycopersicella

CO Leucoptera scitella

CO Lithocollethis spp.

CO Lobesia botrana

CO Ostrinia nubilalis

CO Pandemis spp.

CO Pectinophora gossyp. AP control of

CO Phyllocnistis citrella

CO Pieris spp.

CO Plutella xylostella

CO Scirpophaga spp.

CO Sesamia spp.

CO Sparganothis spp.

CO Spodoptera spp.

CO Tortrix spp.

CO Trichoplusia ni

CO Agriotes spp.

CO Anthonomus grandis

CO Curculio spp.

CO Diabrotica balteata

CO Leptinotarsa spp.

CO Lissorhoptrus spp.

CO Otiorhynchus spp.

CO Aleurothrixus spp.

CO Aleyrodes spp.

CO Aonidielia spp.

CO Aphididae spp.

CO Aphis spp.

CO Bemisia tabaci

CO Empoasca spp.

CO mycus spp.

CO Nephotettix spp.

CO Nilaparvata spp.

CO Pseudococcus spp.

CO Psylla spp.

CO Quadraspidiotus spp

CO Schizaphis spp.

CO Trialeurodes spp.

CO Lyriomyza spp.

CO Oscinella spp.

CO Phorbia spp. AP control of

CO Frankliniella spp.

CO Thrips spp.

CO Scirtothrips aurantii

CO Aceria spp.

CO Acutus spp.

CO Brevipalpus spp.

CO Panonychus spp.

CO Phyllocoptruta spp.

CO Tetranychus spp.

CO Heterodera spp.

CO Meloidogyne spp.

CH Adoxophyes spp.

CH Agrotis spp.

CH Alabama argillaceae

CH Anticarsia gemmatalis

CH Chilo spp.

CH Clysia ambiguella

CH Crocidolomia binotalis

CH Cydia spp.

CH Diparopsis castanea

CH Earias spp.

CH Ephestia spp.

CH Heliothis spp.

CH Hellula and Alis

CH Keiferia lycopersicella

CH Leucoptera scitella

CH Lithocollethis spp.

CH Lobesia botrana

CH Ostrinia nubilalis

CH Pandemis spp.

CH Pectinophora gossyp.

CH Phyllocnistis citrella

CH Pieris spp. AP control of

CH Plutella xylostella

CH Scirpophaga spp.

CH Sesamia spp.

CH Sparganothis spp.

CH Spodoptera spp.

CH Tortrix spp.

CH Trichoplusia ni

CH Agriotes spp.

CH Anthonomus grandis

CH Curculio spp.

CH Diabrotica balteata

CH Leptinotarsa spp.

CH Lissorhoptrus spp.

CH Otiorhynohus spp.

CH Aleurothrixus spp.

CH Aleyrodes spp.

CH Aonidiella spp.

CH Aphididae spp.

CH Apbis spp.

CH Bemisia tabaci

CH Empoasca spp.

CH Mycus spp.

CH Nephotettix spp.

CH Nilaparvata spp.

CH Pseudococcus spp.

CH Psylla spp.

CH Quadraspidiotus spp

CH Schizaphis spp.

CH Trialeurodes spp.

CH Lyriomyza spp.

CH Oscinella spp.

CH Phorbia spp.

CH Frankliniella spp. AP control of

CH Thrips spp.

CH Scirtothrips aurantii

CH Aceria spp.

CH Aculus spp.

CH Brevipalpus spp.

CH Panonychus spp.

CH Phyllocoptruta spp.

CH Tetranychus spp.

CH Heterodera spp.

CH Meloidogyne spp.

SS Adoxophyes spp.

SS Agrotis spp.

SS Alabama argillaceae

SS Anticarsia gemmatalis

SS Chilo spp.

SS Clysia ambiguella

SS Crocidolomia binotalis

SS Cydia spp.

SS Diparopsis castanea

SS Earias spp.

SS Ephestia spp.

SS Heliothis spp.

SS Hellula undalis

SS Keiferia lycopersicella

SS Leucoptera scitella

SS Lithocollethis spp.

SS Lobesia botrana

SS Ostrinia nubilalis

SS Pandemis spp.

SS Pectinophora gossyp.

SS Phyllocnistis citrella

SS Pieris spp.

SS Plutella xylostella

SS Scirpophaga spp. AP control of

SS Sesamia spp.

SS Sparganothis spp.

SS Spodoptera spp.

SS Tortrix spp.

SS Trichopiusia ni

SS Agriotes spp.

SS Anthonomus grandis

SS Curculio spp.

SS Diabrotica balteata

SS Leptinotarsa spp.

SS Lissorhoptrus spp.

SS Otiorhynchus spp.

SS Aleurothrixus spp.

SS Aleyrodes spp.

SS Aonidielia spp.

SS Aphididae spp.

SS Aphis spp.

SS Bemisia tabaci

SS Empoasca spp.

SS Mycus spp.

SS Nephotettix spp.

SS Nilaparvata spp.

SS Pseudococcus spp.

SS Psylla spp.

SS Quadraspidiotus spp

SS Schizaphis spp.

SS Trialeurodes spp.

SS Lyriomyza spp.

SS Oscinella spp.

SS Phorbia spp.

SS Frankliniella spp.

SS Thrips spp.

SS Scirtothrips aurantii

SS Aceria spp. AP control of

SS Aculus spp.

SS Brevipalpus spp.

SS Panonychus spp.

SS Phyllocoptruta spp.

SS Tetranychus spp.

SS Heterodera spp.

SS Meloidogyne spp.

HO Adoxophyes spp.

HO Agrotis spp.

HO Alabama argillaceae

HO Anticarsia gemmatalis

HO Chilo spp.

HO Clysia ambiguella

HO Crocidolomia binotalis

HO Cydia spp.

HO Diparopsis castanea

HO Earias spp.

HO Ephestia spp.

HO Heliothis spp.

HO hellula and alis

HO Keiferia lycopersicella

HO Leucoptera scitella

HO Lithocollethis spp.

HO Lobesia botrana

HO Ostrinia nubilalis

HO Pandemis spp.

HO Pectinophora gossypiella

HO Phyllocnistis citrella

HO Pieris spp.

HO Plutella xylostella

HO Scirpophaga spp.

HO Sesamia spp.

HO Sparganothis spp.

HO Spodoptera spp. AP control of

HO Tortrix spp.

HO Trichoplusia ni

HO Agriotes spp.

HO Anthonomus grandis

HO Curculio spp.

HO Diabrotica balteata

HO Leptinotarsa spp.

HO Lissorhoptrus spp.

HO Otiorhynchus spp.

HO Aleurothrixus spp.

HO Aleyrodes spp.

HO Aonidiella spp.

HO Aphididae spp.

HO Aphis spp.

HO Bemisia tabaci

HO Empoasca spp.

HO Mycus spp.

HO Nephotettix spp.

HO Nilaparvata spp.

HO Pseudococcus spp.

HO Psylla spp.

HO Quadraspidiotus spp

HO Schizaphis spp.

HO Trialeurodes spp.

HO Lyriomyza spp.

HO Oscinella spp.

HO Phorbia spp.

HO Frankliniella spp.

HO Thrips spp.

HO Scirtothrips aurantii

HO Aceria spp.

HO acutus spp.

HO Brevipalpus spp.

HO Panonychus spp. AP control of

HO Phyllocoptruta spp

HO Tetranychus spp.

HO Heterodera spp.

HO Meloidogyne spp.

Table 3: Abbreviations:

Acetyl-CoA carboxylase: ACCase Acetolactate synthase: ALS hydroxyphenylpyruvate dioxygenase: HPPD inhibition of protein synthesis: IPS hormone imitation: HO glutamine synthetase: GS protoporphyrinogen oxidase: PROTOX 5-enolpymvyl-3-phosphoshikirnate synthase: EPSPS

Principle tolerance to plant

ACCase +++ Stone fruit

ACCase -H- + citrus

HPPD Isoxaflutole, Isoxachlotol, Sulcotrione, Cotton Mesotrione

HPPD isoxaflutole, isoxachlotol, sulcotrione, rice mesotrione

HPPD Isoxaflutole, Isoxachlotol, Sulcotrione, Brassica Mesotrione

HPPD isoxaflutole, isoxachlotol, sulcotrione, potatoes mesotrione

HPPD isoxaflutole, isoxachlotol, sulcotrione, tomato mesotrione

HPPD Isoxaflutole, Isoxachlotol, Sulcotrione, Pumpkin Mesotrione

HPPD isoxaflutole, isoxachlotol, sulcotrione, soybean mesotrione

HPPD Isoxaflutole, Isoxachlotol, Sulcotrione, Corn Mesotrione

HPPD Isoxaflutole, Isoxachlotol, Sulcotrione, Wheat Mesotrione

HPPD isoxaflutole, isoxacholotol, sulcotrione, pome fruit mesotrione

HPPD isoxaflutole, isoxachlotol, sulcotrione, stone fruit mesotrione

HPPD isoxaflutole, isoxachlotol, sulcotrione, citrus mesotrione

Nitrilase Bromoxynil, Loxynil Cotton

Nitrilase Bromoxynil, Loxynil Rice

Nitrilase Bromoxynil, Loxynil Brassica

Nitrilase Bromoxynil, Loxynil potatoes

Nitrilase Bromoxynil, Loxynil Tomatoes

Nitrilase Bromoxynil, Loxynil ^• Pumpkin

Nitrilase Bromoxynil, Loxynil Soybeans

*** Included are sulfonylurea compounds, imidazolinones, triazolopyrimidines, dimethoxypyrimidines and N-acylsulfonamides:

Sulfonylurea compounds such as chlorsulfuron, chlorimuron, Ethamethsulfuron, metsulfuron, primisulfuron, prosulfuron, triasulfuron, cinosulfuron, Trifusulfuron, oxasulfuron, bensulfuron, Tribenuron, ACC 322140, Fluzasulfuron, ethoxysulfuron, Fluzasdulfuron, nicosulfuron, rimsulfuron, thifensulfuron, pyrazosulfuron, Clopyrasulfuron, NC 330, Azimsulfuron, Imazosulfuron, sulfosulfuron, amidosulfuron, flupyrsulfuron, CGA 362622

Imidazolinones such as imazamethabenz, imazaquin, imazamethypyr, imazethapyr, imazapyr and imazamox;

Triazole pyrimidines such as DE 511, flumetsulam and chloransulam;

Dimethoxypyrimidines such as pyrithiobac, pyriminobac, bispyribac and pyribenzoxime.

Tolerant to Diclofop-methyl, Fluazifop-P-butyl, Haloxyfop-P-methyl, Haloxyfop-P-ethyl, Quizalafop-P-ethyl, Clodinafop-propargyl, Fenoxaprop-ethyl, Tepraloxydim, Alloxydim, Sethoxydim, Cycloxydim, Cloproxydim, Tralkoxydim, Butoxydim, caloxydim, clefoxydim, clethodim.

&&& chloroacetanilides such as alachlor, acetochlor, dimethenamid

/// Protox Inhibitors: For example, diphenyl ethers such as acifluorfen, aclonifen, bifenox, chloronitrofen, ethoxyfen, fluoroglycofen, fomesafen, lactofen, oxyfluorfen; Imides such as azafenidine, carfentrazone-ethyl, cinidone-ethyl, flumiclorac-pentyl, flumioxazine, fluthiacetemethyl, oxadiargyl, oxadiazone, pentoxazones, sulentrazone, imides and other compounds such as flumipropyne, flupropacil, nipyraclofen and thidiazimine; as well as Fluazola and Pyraflufen-ethyl.

Table 4

List of Examples of Transgenic Plants with Modified Properties:

K>

00

K>

O

OJ

K)

uy

4- K)

AMO 1-1005, L. (Potato) GmbH in antisense orientation relative to the AM02-1012, promoter, flanked by the gbss promoter from AM02-1017, Solanum tuberosum and the polyadenylation AM99-1089 and sequence from Agrobacterium tumefaciens AM99-2003 nostaline synthase gene has been inserted into potato variety Seresta (lines AM02-1003, AMO1-1005, AM02-1012) and Kuras (line AM02-1017) thus reducing the amount of amylose in the starch fraction. Adenosine (acetohydroxyacid synthase) from Arabidopsis thaliana flanked by the nos gene promoter and the octopine synthase polyadenylation sequence from Agrobacterium tumefaciens serves as selectable marker gene conferring tolerance to Imazamox. b) AM99-1089 serves as a reference line. The amount of amylose in the starch fraction is reduced by the amount of amylose in the starch fraction. In addition the neomycin phosphotransferase gene (nptll) connected to the Agrobacterium tumefaciens nopaline synthase promoter and g7 polyadenylation sequence from Agrobacterium tumefaciens has been inserted as selectable marker gene conferring resistance to

4

J-.

QO

*O

O

Table 1. Summary of the genetic elements inserted in MON 89034

Bl-Left Border *: 239 bp DNA region from the B? Left Border region remaining after integration Pp2-e35S: Modified promoter and leader for cauliflower mosaic virus (CaMV) 35S RNA containing the duplicated enhancer region

L3-Cab: 5 'untranslated leader of the wheat chlorophyll a / b binding protein I4-Ractl: intron from the rice actin gene CS5-crylA.105: coding sequence for the Bacillus thuringiensis CrylA.105 protein T6-Hspl7: 3' transcript termination sequence for wheat heat shock protein 17.3, which ends transcription and direct polyadenylation P-FMV: Figwort mosaic virus 35S promoter I-Hsp70: First intron from the maize heat shock protein 70 gene

TS7-SSU-CTP: DNA region containing the targeting sequence for the transit peptide region of maize ribulose 1,5-bisphosphate carboxylase small subunit and the first intron CS-cry2Ab2: coding sequence for a cry2Ab2 protein from Bacillus thuringiensis. This coding

"Jx

Table 6

K *

Examples:

The invention is further illustrated by the following examples, without thereby limiting.

example 1

Single potted transgenic cotton plants with lepidopteran resistance and herbicide resistance (line DP444 BG / RR) are treated in 2 replications against bollworm (Heliothis armigera) larvae. The application is carried out by spray application with the respective active ingredient in the desired application rate.

After the desired time the kill is determined in%. 100% means that all caterpillars have been killed; 0% means that no caterpillars have been killed.

It is a clear improvement in the control of pests in comparison to the not according to the invention treated control plants to recognize.

Example 2

Pots of 5 transgenic maize plants each with Lepidoptera resistance and a herbicide resistance (line SGIII 890 Hx X SGIl 847) are treated in 2 replications against the armyworm (Spodoptera frugiperdά). The application is carried out by spray application with the j eweiligen active ingredient in the desired application rate.

After the desired time the kill is determined in%. 100% means that all caterpillars have been killed; 0% means that no caterpillars have been killed.

It is a clear improvement in the control of pests in comparison to the not according to the invention treated control plants to recognize.

Example 3

Pots containing 5 transgenic maize plants each with a herbicide resistance (line FRI 064LL X FR2108) are treated in 2 replications against the armyworm (Spodoptera frugiperdά). The application is carried out by spray application with the respective active ingredient in the desired application rate.

After the desired time the kill is determined in%. 100% means that all caterpillars have been killed; 0% means that no caterpillars have been killed.

It is a clear improvement in the control of pests in comparison to the not according to the invention treated control plants to recognize.

Examples 4 to 6

The invention will be further illustrated by the following examples without thereby limiting them. The spirotetramat mentioned in the tables is compound 1-4.

The erfϊndungsgemäße effect, i. The synergistic effect between the transgenic property of the plant and the active ingredient treatment can be demonstrated by the method of S. R. Colby, Weeds 1_5 (1967), 20-22. This is based on the following calculation basis and assumption ("Colby formula"):

If

X means the degree of killing, expressed in% of the untreated and non-transgenically modified control, when the active substance A is used at a rate of m g / ha or in a concentration of m ppm,

Y is the degree of killing, expressed as% of the untreated and non-transgenic modified control, using a transgenic plant and

E the degree of killing, expressed in% of untreated and non-transgenic modified

Control, when using the active substance A and the use of a transgenically modified plant, wherein the application rate of m and n is g / ha or in a concentration of m and n ppm,

then

XYE = X ₊ Y- - ΪÖÖ ^~ .

If the actual kill rate (ie, observed effect) is greater than calculated, then the combination of drug treatment and transgenic modified plant is over-additive in its killing, ie, there is a synergistic effect between the drug treatment and the use of a transgenic plant. In this case, therefore, the actually observed kill rate must be greater than the value for the degree of kill (E) calculated from the above formula. In the following Examples 4 to 6, the observed kill rate is greater than the calculated kill rate. Thus, the synergistic effect according to the invention is present. According to the method of the invention, a kill of harmful organisms of at least 20%, preferably at least 30%, in particular at least 50%, is observable four days after the treatment compared to the control. Mortalities of at least 80 or 90% can be achieved four days after treatment. One day after the treatment, the killing of harmful organisms can be at least 20% or 30%.

Example 4

Individually potted transgenic cotton plants with a lepidopteran resistance and herbicide resistance (line DP444 BG / RR) populated with a mixed population of cotton aphid (Aphis gossypii) are spray-applied with the appropriate active substance.

After the desired time the kill in% is determined by counting the animals. 100% means that all aphids have been killed; 0% means that no aphids have been killed.

It is a clear improvement in the control of pests in comparison to the not according to the invention treated control plants to recognize.

* observed according to the invention = found effect

** calculated = calculated effect according to the "Colby formula" Example 5

Pots of 5 transgenic maize plants each with coleopteran, lepidopteran and / or herbicide resistance (lines LH332RR X LH324BT, HC33CRW x LH287BTCRW, HCL201CRW2RR x LH324 and FR1064LL x FR 2108, respectively) are treated in 2 replications against the armyworm (Spodoptera frugiperda) , The application is carried out by spray application with the respective active ingredient in the desired application rate.

After the desired time, the kill in% is determined by paying the animals. 100% means that all caterpillars have been killed; 0% means that no caterpillars have been killed.

It is a clear improvement in the control of pests in comparison to the not according to the invention treated control plants to recognize.

* observed according to the invention = found effect

** calculated = calculated effect according to the "Colby formula"

* observed according to the invention = found effect

** calculated = calculated effect according to the "Colby formula"

Example 6

Pots of 5 transgenic maize plants each with coleopteran, lepidopteran and / or herbicide resistance (lines HC33CRW x LH287BTCRW or TR 47 x TR 7322 BT) are treated in 2 replications against larvae of the carrion owl (Spodoptera exigua). The application is carried out by spray application with the respective active ingredient in the desired application rate.

After the desired time the kill in% is determined by counting the animals. 100% means that all caterpillars have been killed; 0% means that no caterpillars have been killed.

It is a clear improvement in the control of pests in comparison to the not according to the invention treated control plants to recognize.

* observed according to the invention = found effect

** calculated = calculated effect according to the "Colby formula"

Claims

claims

A method for improving the utilization of the production potential of a transgenic plant, characterized in that the plant is treated with an effective amount of at least one 3-aryl-pyrrolidine-2,4-dione derivative.

2. The method according to claim 1, characterized by a 3-aryl-pyrrolidine-2,4-dione derivative of the formula I.

3. The method according to claim 1 or 2, characterized by a 3-aryl-pyrrolidine-2,4-dione derivative of the formula 1-1 to 1-13.

4. The method according to claim 3, characterized by substantially pure cis isomers of the compounds 1-3 and / or 1-4.

5. The method according to any one of claims 1 to 4, characterized in that the plant has at least one genetically modified structure or a tolerance according to Table 1.

6. The method according to any one of claims 1 to 4, characterized in that it is a plant with at least one modified mode of action according to Table 3.

7. The method according to any one of claims 1 to 4, characterized in that it is a transgenic plant according to one of Tables 4 to 6.

8. The method according to any one of claims 1 to 4, characterized in that the plant contains at least one genetic modification according to Table 2.

9. The method according to any one of claims 1 to 4, characterized in that the transgenic plant contains at least one gene or a gene fragment coding for a Bt toxin.

10. The method according to claim 1 or 2, characterized in that it is in the transgenic plant to a vegetable, corn, soybean, cotton, tobacco, rice,

Sugar beet or potato plant.

11. The method according to any one of the above claims, characterized in that the 3-arylpyrrolidine-2,4-dione derivative for the control of aphids (Aphidina), white flies (Trialeurodes), thrips (Thysanoptera), spider mites (Arachnida), leprosy or mealybugs (Coccoidae or Pseudococcoidae) are used.

12. The method according to any one of the above claims, characterized in that application rates of the 3-aryl-pyrrolidine-2,4-dione derivative between 0.1 g / ha and 5.0 kg / ha, preferably 0.1 to 500 g / ha, more preferably 50 to 500 g / ha, especially preferred

50 to 200 g / ha are used.

13. The method according to any one of the preceding claims, characterized in that the application form of the 3-aryl-pyrrolidine-2,4-dione derivative is present in a mixture with at least one mixing partner.

14. The method according to any one of the preceding claims, characterized in that with the treatment of the plant with the 3-aryl-pyrrolidine-2,4-dione derivative, a kill of harmful organisms of at least 20% compared to the control is achieved.

15. Plant parts, in particular seed or propagation material, transgenic plants, characterized in that they are obtainable by a method according to one of claims 1 to 13.

16. Plant parts, in particular seed or propagation material, transgenic plants, characterized in that they have been treated by a method according to any one of claims 1 to 13.