EP2097293A2 - System and method for whole-body cryotherapy - Google Patents
System and method for whole-body cryotherapyInfo
- Publication number
- EP2097293A2 EP2097293A2 EP07858745A EP07858745A EP2097293A2 EP 2097293 A2 EP2097293 A2 EP 2097293A2 EP 07858745 A EP07858745 A EP 07858745A EP 07858745 A EP07858745 A EP 07858745A EP 2097293 A2 EP2097293 A2 EP 2097293A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- treatment chamber
- prechamber
- temperature
- self
- supporting structure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B60—VEHICLES IN GENERAL
- B60P—VEHICLES ADAPTED FOR LOAD TRANSPORTATION OR TO TRANSPORT, TO CARRY, OR TO COMPRISE SPECIAL LOADS OR OBJECTS
- B60P3/00—Vehicles adapted to transport, to carry or to comprise special loads or objects
- B60P3/20—Refrigerated goods vehicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D11/00—Washing devices or gaseous curative baths specially adapted to veterinary purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/0053—Cabins, rooms, chairs or units for treatment with a hot or cold circulating fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B60—VEHICLES IN GENERAL
- B60P—VEHICLES ADAPTED FOR LOAD TRANSPORTATION OR TO TRANSPORT, TO CARRY, OR TO COMPRISE SPECIAL LOADS OR OBJECTS
- B60P3/00—Vehicles adapted to transport, to carry or to comprise special loads or objects
- B60P3/14—Vehicles adapted to transport, to carry or to comprise special loads or objects the object being a workshop for servicing, for maintenance, or for carrying workmen during work
Definitions
- the present invention relates to a system, as well as its method of setting up, for whole body cryotherapy applicable to human or animal subjects, this system comprises a treatment chamber and refrigerating means able to bring or maintain a temperature less than -80 0 C the atmosphere of this treatment chamber.
- this processing chamber and said refrigerating means, or at least one of these two elements are mounted on at least one mobile or transportable self-supporting structure, in a manner allowing implementation from said self-supporting structure .
- It also relates to a whole-body cryotherapy system provided with pre-chambers at intermediate temperatures, defining a modifiable or removable dual path between the treatment chamber and the outside, and comprising means for local cryotherapy.
- the main field of the invention is that of treatment very cold, mainly applied to living beings, particularly at temperatures below -80 0 C, for example between -100 0 C or -120 0 C, often in the vicinity -110 0 C.
- cancer Although commonly referred to as “cryotherapy”, such treatment may have other than therapeutic purposes, such as comfort, aesthetics or regularization of physical performance.
- Such types of treatment can also be used to improve a person's general comfort by reactivating his metabolism. Some results can also be obtained aesthetically, for example by an action on the state or appearance of the skin.
- the existing systems are installed in some specialized centers, therapeutic type or in some sports complexes or specialized in sports medicine.
- Such an installation is based on a thermally insulated chamber, cooled by liquid nitrogen or by a special compressor, for example with three compression stages arranged in cascade.
- Such compressors are of a very specialized technology, and differ greatly from conventional freezing plants, which are able to reach at best only -60 0 C, and most often -40 0 C only.
- This type of compressor uses specific fluids, represents a significant consumption, and represents a significant cost and have been developed only recently.
- the warm-up time remains important, since the change from -60 ° C. to the treatment temperature of -110 ° C. may require between three and four hours of operation.
- Some systems are equipped with one or two prechambers, in which the temperature is maintained at intermediate temperatures, and through which the subjects pass to access or exit the treatment chamber.
- the capacity of a system may sometimes be insufficient, even at two prechambers, for example to treat in optimal time all players of both teams at the end of a meeting of team sports, either at least 22 players in football or 30 in rugby.
- the capacity of a two-room installation is given for 10-12 persons / hour and up to 20-25 persons / hour by Xolod company information.
- An object of the invention is to overcome all or part of these disadvantages, and in particular:
- the invention provides a whole-body cryotherapy system for human or animal subjects, comprising
- said processing chamber and said refrigerating means, or at least one of these two elements are mounted on at least one mobile or transportable self-supporting structure, in a manner allowing implementation from said self-supporting structure .
- This self-supporting structure may be for example a module or a container containing these elements or a platform supporting these elements.
- the self-supporting structure is integrated with a road vehicle or a road trailer, or comprises means of attachment to such a vehicle or trailer.
- This self-supporting structure may also comprise gripping means for handling said self-supporting structure by lifting or handling means, which may themselves be fixed on such a vehicle or trailer.
- cryotherapy system it is thus possible to move the cryotherapy system, to be able to set it up temporarily and punctually on the place where it is requested.
- This system can be moved in one or more parts, for example in modules or monobloc containers, which can be fixed or juxtaposed between them.
- the modules constitute assemblable cells and having the necessary connections to make the assembly operational in a simple manner while avoiding or limiting assembly or adjustment operations at startup.
- This type of service can be aimed at many users who did not previously have the need or the means to invest in an on-site installation, for example small sports training for a few special occasions, at a corresponding cost. to such use.
- the treatment chamber communicates with the outside through one or more successive prechambers, each of sufficient size to contain at least one subject to be treated, and whose respective atmospheres are brought or maintained at one or more temperatures intermediates between the outside temperature and the temperature of the treatment chamber.
- the system may comprise local cryotherapy means that can be used from within at least one prechamber.
- local cryotherapy means that can be used from within at least one prechamber.
- the skin temperature of a human subject in an environment at +20 ° C. is normally about + 32 ° C.
- Local cryotherapy involves cooling the skin by at least 15 ° C to initiate a vasodilatory reaction from within the body. After exposure to -110 0 C, the surface temperature has already fallen, for example around + 25 ° C.
- Local cryotherapy is applied in a prechamber at -60 0 C or at -1O 0 C to bring the skin to the temperature triggering vasodilation, for example around +17 0 C.
- the effects of this local cryotherapy will be more effective because the cold atmosphere and the reaction already engaged in the body of the subject, and will also be obtained more quickly due to the already lowered surface temperature.
- such a local treatment which would take about 10 minutes in an environment at + 20 ° C. may require only about a minute in an environment at -10 ° C. and after exposure at -110 ° C.
- At least one antechamber may comprise a physical separation device defining at least two separate paths between
- the system comprises at least two separable modules, at least one of which is mounted on a mobile or transportable self-supporting structure, so as to allow implementation from said self-supporting structure, one said modules comprising at least the treatment chamber, and the other of said modules comprising at least the refrigerating means or at least one prechamber.
- Such modules can be transported on different vehicles, or distributed on a vehicle and its trailer, which makes the system less cumbersome and more flexible transportation.
- the refrigerating means are mounted on a mobile or transportable self-supporting structure.
- the system then comprises connection means for connecting said refrigerating means removably to one or more processing chambers constructed or transported independently of said refrigerating means.
- Such a configuration makes it possible to position the treatment chamber in advance and save time on the installation. It also makes it possible to install several treatment rooms, possibly permanent, in different places. These different treatment chambers can then be used with the same refrigeration module provided at the desired time, and the cost will be more easily amortized or profitable.
- the refrigerating means and the treatment chamber are mounted on one or more structures self-supporting mobile or transportable, and the system may include connection means for releasably connecting said processing chamber to one or more prechambers constructed or transported independently of said refrigerating means.
- the prechambers can thus be part of fixed installations, such as changing rooms or a physiotherapy center.
- Cryotherapy can be practiced in a place where are gathered means and personnel necessary for other treatments, complementary or useful to the same subjects. These other treatments may include electrotherapy, light therapy, laser, massage, hydrotherapy, and other physiotherapy techniques.
- system further comprises second refrigerating means, for example a refrigeration unit of a more conventional and less expensive technology.
- These second means can ensure the operation of local cryotherapy means. They can also ensure all or part of the obtaining or maintaining temperature of at least one prechamber of a temperature greater than the treatment chamber. They can still provide a supplement or a preparation for obtaining or maintaining the temperature of the treatment chamber.
- the invention also provides a method for preparing such a whole body cryotherapy system.
- This method comprises a step of transporting the refrigerating means and / or the treatment chamber to a site chosen for occasional or non-permanent use, followed by a step of heating the treatment chamber.
- FIG. 1 is a diagram in side view illustrating a system according to the invention mounted on a semitrailer
- FIG. 2 is a diagram in plan view illustrating the organization of a system according to the invention mounted on a heavy goods vehicle;
- FIG. 3 is a diagram in plan view illustrating the organization of a system according to the invention in a variable geometry embodiment
- FIG. 4 is a diagram in side view illustrating a system according to the invention mounted on a carrier vehicle and a separate trailer;
- FIG. 5 is a diagram in plan view illustrating an embodiment of the invention with mobile refrigerating chambers treatment chamber and fixed prechambers;
- FIGURE 6 is a diagram in top view illustrating an embodiment of the invention with mobile refrigerating means and fixed treatment chamber.
- FIG. 1 and FIG. 2 illustrates an embodiment of the invention in which all the elements of the cryotherapy system are mounted permanently and functionally on a heavy vehicle, here in the form of a semitrailer 100 constituting the self-supporting and adaptable structure to a road tractor 19.
- a heavy vehicle here in the form of a semitrailer 100 constituting the self-supporting and adaptable structure to a road tractor 19.
- the principle of the semi-trailer vehicle allows a certain flexibility of use and an economy of investment due to the separable and interchangeable road tractor.
- a similar embodiment could also be achieved on the basis of a coach-type vehicle, for a better compactness on the road and a more typical presentation tourism and comfort.
- Onboard parts comprise, starting from the front of functional part: a technical compartment 11 bringing together the specific refrigerant compressor and a generator, the control room 12, then the very cold room 130.
- the refrigerating and control elements can typically be of the same type as in existing fixed installations, as provided for example by the company Cryo Medizin and / or the company Bock.
- the technical compartment 11 includes a generator supplying all or part of the system, particularly en route. It also includes refrigeration means, for example a specific triple compressor stage to obtain the temperature of -110 0 C in the treatment chamber.
- the refrigerating means are suspended by at least one suspended structure, mounted so as to allow implementation from said suspended structure, thus limiting the vibrations they receive during transport.
- Such a suspended structure is for example a frame supporting all the elements of the triple-stage compressor, and mounted on the self-supporting structure 100 by means of damping means of a known type, such as a deformable material of the type high-density foam, or closed-cell foam, or rubber mounts, spring-loaded system with hydraulic dampers or hydraulic or oleo-pneumatic suspension.
- damping means of a known type, such as a deformable material of the type high-density foam, or closed-cell foam, or rubber mounts, spring-loaded system with hydraulic dampers or hydraulic or oleo-pneumatic suspension.
- the suspension means may also be located outside the self-supporting structure, that is to say for example between the vehicle and the box .
- the control room 12 includes all the means for controlling and monitoring the operation of the system and monitoring the treatment. It has an external access door 121 and a thermally insulated door 122 communicating with the treatment chamber 13, and provided with a window 123 allowing a view on the inside of the treatment chamber 13.
- the very cold room is here of a type called "tri-sas" and comprising three successive cabins 13, 14 and 15, thermally insulated and communicating with each other through openings with thermally insulated doors.
- This cabin 15 is a first prechamber and forms a temperature intermediate bearing, with an internal temperature of -10 0 C during operation. From this first prechamber 15 can be accessed by a door 141 to another cabin constituting a second prechamber 14, where there is an internal temperature of -60 ° C. From this second prechamber 14, one can access another cabin constituting the chamber of 13.
- This processing chamber 13 is also provided with an outer door 132, which can serve as technical access or emergency door.
- the first antechamber 15 and the second antechamber 14 are subdivided into two parts 15a, 15b and 14a, 14b respectively by a physical separator, for example a partition 152, 142 or possibly a simple guardrail .
- a physical separator for example a partition 152, 142 or possibly a simple guardrail .
- this partition 152 goes from the outer door 151 to a door 141 communicating with the second prechamber 14.
- this partition 142 goes from this same access door 141 to the door 131 communicating with the treatment chamber 13.
- This partition 152 is provided at each of its ends with a movable gate 153 and 154, which can be controlled from the control room 12.
- These gates 153 and 154 can also be designed to move automatically or to be moved manually so as to allow passage to each of the parts 15a and 15b respectively of the antechamber 15 that from one of the access doors 151 respectively 141.
- the partition 142 of the second prechamber 14 is provided at each of its ends with a movable gate 143 and 144, which can be controlled from the control room 12.
- These gates 143 and 144 can also be designed to move automatically or be moved manually so as to allow passage to each of the parts 14a and 14b respectively of the antechamber 14 that from one of the access doors 141 respectively 131.
- these different doors 151, 141 and 131 are sufficiently wide, or open in two parts, or each comprise two separate doors, to allow the circulation in both directions simultaneously without wicket to maneuver.
- one or more partitions making at least one physical separation device between two prechambers or within a prechamber are movable or removable.
- a possible configuration is then to remove the partitions 142 and 152 of each prechambers 14 and 15, to increase the available width or facilitate maintenance.
- the separation between the first prechamber 15 and the second prechamber 14 can also be provided movable or removable, which allows to obtain a single antechamber of greater length. By removing the partition 145 between the first antechamber 15 and the second prechamber 14, a "bi-sas" type system is thus obtained.
- the outer door 151 and the access door 131 to the treatment chamber are provided to a sufficient size to let such bulky subjects, for example by two independent leaves.
- the separation between the second prechamber 14 and the treatment chamber 13 can also be provided movable or removable.
- a "mono-sas" type system of greater capacity is thus obtained.
- FIGURE 3 is illustrated an embodiment where the system comprises at least one movable part 101, 103 allowing a modification of the horizontal dimensions of at least one element that it supports.
- Such a variable geometry configuration for example unfoldable or expandable, allows to have sufficient space to stop and in use, without generating too much space during transport or exceed certain regulatory templates or passage on the road.
- the semi-trailer 100 comprises a side platform 101 slidable under the floor of the cabins 12 and 13 or can be folded on the outside of their side wall.
- This platform 101 is provided with a folding staircase 102 and allows, at a standstill, convenient and safe access to the control room 21 and to the outer door of the treatment chamber 13.
- the semitrailer 100 comprises a structure 103 fitting around the outer walls of the second prechamber 14, and being able to slide rearwardly to release a space constituting the first antechamber 15, into which can then be mounted the removable partitions 152 and 142.
- variable geometry can of course be combined with other embodiments of the invention, for example with a single vehicle, or an unloadable box or an independent trailer.
- FIGURE 4 is illustrated an embodiment of the invention where the system is divided into two separate modules that can be connected to each other for operation.
- a first module 41 is carried by a heavy vehicle 49 and a second module 42 is carried by a trailer 48, which can be towed by the same vehicle 49 or be moved independently.
- the main vehicle 49 carries the technical compartment 11, the control room 12 and the treatment chamber 13, and the trailer 48 carries the two prechambers 14 and 15.
- One or the other of the two modules 41 and 42 further comprises connection means 488 for a simple and reversible connection of the different fluids or information, and a protection and thermal insulation of the passage between different zones 13, 14 of low temperature.
- the method may also include pre-cooling at least the treatment chamber with second refrigerating means able to operate during the displacement or the steps of said movement.
- second refrigerating means 412 capable of operating en route or by connection to the electrical sector in the steps, for example a conventional compressor group as used in transport frozen.
- FIGURE 5 is illustrated an implementation of the system in an embodiment comprising the processing chamber mounted without prechambers on a vehicle 59.
- the vehicle includes a technical compartment 51, the control room 52 and a treatment chamber 53. This vehicle is placed in front of a prechamber 54 forming part of a fixed installation, for example within a building 50.
- the system comprises connecting means, for example an electrical and computer connection 547 and an expandable lock 548, which can be mounted outside the antechamber 54 or behind the processing chamber 53.
- the transporting step is then followed by a step for connecting or securing the treatment chamber to at least one prechamber constructed or transported independently of the treatment chamber, thus making it possible to use existing installations on site or made beforehand.
- the system also comprises second on-board refrigeration means 592, capable of operating during the journey or at the stages, to ensure pre-cooling of the treatment chamber 53, and thus to reduce the preparation time of the assembly after arrival of the vehicle .
- the installation 50 also comprises a technical room 512 comprising second fixed refrigerating means 512, which make it possible to ensure the cooling or the pre-cooling of the second prechamber 54, as well as the cooling of the first prechamber 55 and the operation of the local processing devices 549 and 559 of the first and second precursors 55 and 54.
- FIGURE 6 an embodiment of the invention wherein the system comprises a module 61 including the specific refrigerating means.
- This module is mounted on a vehicle 69, for example in a self-supporting housing that can be unloaded using an on-board crane or not.
- This module is brought close to an installation, which can itself be fixed or mobile in whole or part, for example integrated in a building 60.
- This installation comprises a processing chamber 63 and a control room 62 to which the refrigerating means of the module 61 are connected by connection means 68 for fluids and information.
- the refrigerating means of the module 61 may also comprise a mobile part, for example comprising a condenser group, permanently connected to the remainder of said module, and which can be moved a short distance to mate or fit into or near the treatment chamber 13.
- the installation 60 also comprises a technical room 612 comprising second refrigerating means, which make it possible to ensure the pre-cooling of the treatment chamber 63 and the second prechamber 64, as well as the cooling of the first prechamber 65 and the operation of the devices. 649 and 659 local processing of the first and second prechambers 65 and 64.
- each module may also, alternatively, be integrated with a vehicle or trailer or be mounted on a frame or in a box 480 separable from said vehicle or trailer 48.
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0610658A FR2909543B1 (en) | 2006-12-07 | 2006-12-07 | SYSTEM AND METHOD FOR CRYOTHERAPY OF THE WHOLE BODY. |
PCT/FR2007/052407 WO2008068441A1 (en) | 2006-12-07 | 2007-11-27 | System and method for whole-body cryotherapy |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2097293A2 true EP2097293A2 (en) | 2009-09-09 |
EP2097293B1 EP2097293B1 (en) | 2012-09-05 |
Family
ID=37989031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07858745A Revoked EP2097293B1 (en) | 2006-12-07 | 2007-11-27 | System and method of preparing said system for whole-body cryotherapy |
Country Status (6)
Country | Link |
---|---|
US (1) | US8316652B2 (en) |
EP (1) | EP2097293B1 (en) |
ES (1) | ES2393633T3 (en) |
FR (1) | FR2909543B1 (en) |
PT (1) | PT2097293E (en) |
WO (1) | WO2008068441A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018186851A1 (en) * | 2017-04-05 | 2018-10-11 | Lovett Jared | Device and method of use for equine whole-body cryotherapy |
FR3076448A1 (en) * | 2018-01-10 | 2019-07-12 | Alexia Lemahieu | DEVICE FOR TREATING AN ANIMAL LIVING WITH COLD AND CORRESPONDING CONTAINER |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090013712A1 (en) * | 2007-07-11 | 2009-01-15 | Robert William Norris | Refrigerated trailer and method for same |
US20150265460A1 (en) * | 2012-06-07 | 2015-09-24 | Khasanbi Khabievich Erganokov | Installation for general air cryotherapy |
CH707300B1 (en) * | 2012-12-11 | 2014-06-13 | Vladimir Shuppo | cryogenic cell. |
US11166842B2 (en) * | 2014-09-30 | 2021-11-09 | Jonas Kuehne | Method and apparatus for uniform total body cryotherapy |
US10271986B1 (en) | 2015-03-13 | 2019-04-30 | Impact Cryotherapy, Inc. | Method and system for providing whole body cryotherapy |
FR3040665B1 (en) * | 2015-09-04 | 2019-05-17 | 321 Perform Sarl | TRAILER ASSEMBLY FORMING A MOBILE SPORTS CLINIC |
FI126430B (en) * | 2015-12-16 | 2016-11-30 | Oy Cryon Ltd | Cold treatment system |
US10765551B1 (en) | 2016-10-12 | 2020-09-08 | Impact Cryotherapy, Inc. | Method and system for providing whole body cryotherapy |
FR3072017B1 (en) * | 2017-10-11 | 2022-06-17 | Marie Andree Derambure | WHOLE BODY CRYOTHERAPY FOR HORSES |
KR102016411B1 (en) * | 2019-01-30 | 2019-09-03 | 주식회사 엠원인터내셔널 | Whole body cryo therapy and light therapy |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
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US3421336A (en) * | 1967-06-05 | 1969-01-14 | Union Carbide Corp | Intransit liquefied gas refrigeration system |
US4060400A (en) * | 1975-08-22 | 1977-11-29 | Henry L. Franke | Refrigerated semitrailer truck for long and local deliveries |
US4498306A (en) * | 1982-11-09 | 1985-02-12 | Lewis Tyree Jr | Refrigerated transport |
US4576010A (en) * | 1983-10-18 | 1986-03-18 | Nhy-Temp, Inc. | Cryogenic refrigeration control system |
DE8713858U1 (en) | 1987-10-15 | 1988-01-14 | Cadena Medical Laser Gmbh, 4800 Bielefeld, De | |
US5161848A (en) * | 1990-11-19 | 1992-11-10 | Kidron, Inc. | Refrigerated vehicle body |
US20020129613A1 (en) * | 2000-10-10 | 2002-09-19 | Thermo King Corporation | Cryogenic refrigeration unit suited for delivery vehicles |
US6378319B1 (en) * | 2000-10-27 | 2002-04-30 | The Mani Brothers | Multi-compartment multi-climate delivery vehicle |
WO2006045124A1 (en) | 2004-10-21 | 2006-04-27 | Morne Inus Van Rooyen | A towed vehicle |
-
2006
- 2006-12-07 FR FR0610658A patent/FR2909543B1/en not_active Expired - Fee Related
-
2007
- 2007-11-27 EP EP07858745A patent/EP2097293B1/en not_active Revoked
- 2007-11-27 WO PCT/FR2007/052407 patent/WO2008068441A1/en active Application Filing
- 2007-11-27 ES ES07858745T patent/ES2393633T3/en active Active
- 2007-11-27 PT PT07858745T patent/PT2097293E/en unknown
- 2007-11-27 US US12/517,911 patent/US8316652B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
See references of WO2008068441A1 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018186851A1 (en) * | 2017-04-05 | 2018-10-11 | Lovett Jared | Device and method of use for equine whole-body cryotherapy |
FR3076448A1 (en) * | 2018-01-10 | 2019-07-12 | Alexia Lemahieu | DEVICE FOR TREATING AN ANIMAL LIVING WITH COLD AND CORRESPONDING CONTAINER |
Also Published As
Publication number | Publication date |
---|---|
FR2909543A1 (en) | 2008-06-13 |
ES2393633T3 (en) | 2012-12-26 |
PT2097293E (en) | 2012-11-16 |
FR2909543B1 (en) | 2009-12-11 |
WO2008068441A1 (en) | 2008-06-12 |
WO2008068441A8 (en) | 2008-09-04 |
US20100313579A1 (en) | 2010-12-16 |
US8316652B2 (en) | 2012-11-27 |
EP2097293B1 (en) | 2012-09-05 |
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