EP2081550A4 - Coating capsules with active pharmaceutical ingredients - Google Patents

Coating capsules with active pharmaceutical ingredients

Info

Publication number
EP2081550A4
EP2081550A4 EP07752721.6A EP07752721A EP2081550A4 EP 2081550 A4 EP2081550 A4 EP 2081550A4 EP 07752721 A EP07752721 A EP 07752721A EP 2081550 A4 EP2081550 A4 EP 2081550A4
Authority
EP
European Patent Office
Prior art keywords
active pharmaceutical
pharmaceutical ingredients
coating capsules
capsules
coating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP07752721.6A
Other languages
German (de)
French (fr)
Other versions
EP2081550B1 (en
EP2081550B2 (en
EP2081550A2 (en
Inventor
Abdel Fawzy
George Bobotas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reliant Pharmaceuticals Inc
Original Assignee
Reliant Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38475595&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP2081550(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US11/488,181 external-priority patent/US20070036862A1/en
Priority claimed from US11/494,799 external-priority patent/US20070196465A1/en
Application filed by Reliant Pharmaceuticals Inc filed Critical Reliant Pharmaceuticals Inc
Publication of EP2081550A2 publication Critical patent/EP2081550A2/en
Publication of EP2081550A4 publication Critical patent/EP2081550A4/en
Publication of EP2081550B1 publication Critical patent/EP2081550B1/en
Application granted granted Critical
Publication of EP2081550B2 publication Critical patent/EP2081550B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Inorganic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP07752721.6A 2006-03-09 2007-03-09 Coating capsules with active pharmaceutical ingredients Active EP2081550B2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US78030606P 2006-03-09 2006-03-09
US11/488,181 US20070036862A1 (en) 2005-07-18 2006-07-18 Treatment with azetidinone-based cholesterol absorption inhibitors and omega-3 fatty acids and a combination product thereof
US11/494,799 US20070196465A1 (en) 2005-07-28 2006-07-28 Treatment with dihydropyridine calcium channel blockers and omega-3 fatty acids and a combination product thereof
US84001206P 2006-08-25 2006-08-25
US85129406P 2006-10-13 2006-10-13
US85683206P 2006-11-06 2006-11-06
US88044107P 2007-01-16 2007-01-16
PCT/US2007/006039 WO2007103557A2 (en) 2006-03-09 2007-03-09 Coating capsules with active pharmaceutical ingredients

Publications (4)

Publication Number Publication Date
EP2081550A2 EP2081550A2 (en) 2009-07-29
EP2081550A4 true EP2081550A4 (en) 2013-12-11
EP2081550B1 EP2081550B1 (en) 2018-04-18
EP2081550B2 EP2081550B2 (en) 2021-05-26

Family

ID=38475595

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07752721.6A Active EP2081550B2 (en) 2006-03-09 2007-03-09 Coating capsules with active pharmaceutical ingredients

Country Status (3)

Country Link
EP (1) EP2081550B2 (en)
JP (1) JP5628480B2 (en)
WO (1) WO2007103557A2 (en)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007103557A2 (en) * 2006-03-09 2007-09-13 Reliant Pharmaceuticals, Inc. Coating capsules with active pharmaceutical ingredients
US8784886B2 (en) 2006-03-09 2014-07-22 GlaxoSmithKline, LLC Coating capsules with active pharmaceutical ingredients
EP2046305A2 (en) * 2006-06-26 2009-04-15 Valpharma S.A. Pharmaceutical composition for the oral administration of omega polyenoic fatty acids
JP2011500043A (en) * 2007-10-17 2011-01-06 ユニリーバー・ナームローゼ・ベンノートシヤープ Omega-3 fatty acids and / or omega-6 fatty acids and / or their esters encapsulated with a coating
ITMI20072142A1 (en) 2007-11-08 2009-05-09 Yervant Zarmanian PHARMACEUTICAL COMPOSITIONS CONTAINING STATIN AND OMEGA-3 FATTY ACID DERIVATIVES
EA201200829A1 (en) * 2008-01-10 2012-11-30 Такеда Фармасьютикал Компани Лимитед COMPOSITION CAPSULES
ITFI20080243A1 (en) * 2008-12-15 2010-06-16 Valpharma Sa FORMULATIONS FOR ORAL ADMINISTRATION OF OMEGA POLIENOIC FATTY ACIDS IN COMBINATION WITH NATURAL OR SEMI-SYNTHETIC STATINES.
EP3563842A1 (en) 2009-04-29 2019-11-06 Amarin Pharmaceuticals Ireland Limited Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
RU2538691C2 (en) 2009-04-29 2015-01-10 Амарин Фарма, Инк. Stable pharmaceutical compositions and methods for using them
LT3318255T (en) 2009-06-15 2021-05-25 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating stroke in a subject on concomitant statin therapy
CA2775339C (en) 2009-09-23 2017-03-28 Amarin Corporation Plc Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same
ES2363965B1 (en) * 2009-11-20 2013-01-24 Gp Pharm S.A. CAPSULES OF BETABLOCKING ACTIVE PRINCIPLES AND ESTERS OF POLYINSATURATED FATTY ACIDS.
ES2364011B1 (en) * 2009-11-20 2013-01-24 Gp Pharm, S.A. CAPSULES OF PHARMACEUTICAL ACTIVE AND ESTERS OF POLYINSATURATED FATTY ACIDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES.
ES2363964B1 (en) * 2009-11-20 2012-08-22 Gp Pharm, S.A. CAPSULES OF PHARMACEUTICAL ACTIVE PRINCIPLES AND ESTERS OF POLYINSATURATED FATTY ACIDS.
CA2706270C (en) * 2010-06-03 2020-01-07 Accucaps Industries Limited Pharmaceutical formulations of statins and omega-3 fatty acids for encapsulation
CA2706272C (en) * 2010-06-03 2020-05-05 Accucaps Industries Limited Multi phase soft gel capsules, apparatus and method thereof
WO2012002464A1 (en) 2010-06-30 2012-01-05 持田製薬株式会社 ω3 FATTY ACID COMPOUND PREPARATION
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
NZ744990A (en) 2010-11-29 2019-10-25 Amarin Pharmaceuticals Ie Ltd Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
KR101310710B1 (en) * 2011-03-23 2013-09-27 한미약품 주식회사 Oral complex composition comprising omega-3 fatty acid ester and hmg-coa reductase inhibitor
US20140294959A1 (en) 2011-05-20 2014-10-02 Astrazeneca Uk Limited Pharmaceutical Composition of Rosuvastatin Calcium
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
KR101466617B1 (en) * 2011-11-17 2014-11-28 한미약품 주식회사 ORAL COMPLEX FORMULATION COMPRISING OMEGA-3 FATTY ACID AND HMG-CoA REDUCTASE INHIBITOR WITH IMPROVED STABILITY
WO2013176455A1 (en) * 2012-05-22 2013-11-28 건일제약 주식회사 Multilayer coating form of orally administered pharmaceutical composition containing omega-3 fatty acid or alkyl ester thereof and statin based drug
US20150265566A1 (en) 2012-11-06 2015-09-24 Amarin Pharmaceuticals Ireland Limited Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
WO2014143625A1 (en) * 2013-03-13 2014-09-18 Armetheon, Inc. Budiodarone formulations
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
GB2512098A (en) * 2013-03-20 2014-09-24 Roly Bufton An oral dosage form
GB2529599B (en) 2013-05-23 2017-02-15 Barlean's Organic Oils Llc Rotary die system
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
WO2015195662A1 (en) 2014-06-16 2015-12-23 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids
CA2963895A1 (en) 2014-10-31 2016-05-06 Barlean's Organic Oils, Llc Method and apparatus for the manufacture of softgels
US20170119680A1 (en) 2015-10-30 2017-05-04 R.P. Scherer Technologies, Llc Extended release film-coated capsules
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
WO2019204326A1 (en) * 2018-04-16 2019-10-24 Alsar Ltd Partnership Compositions and methods for sustained release of flecainide
FI4056176T3 (en) 2018-09-24 2024-05-30 Amarin Pharmaceuticals Ie Ltd Methods of reducing the risk of cardiovascular events in a subject
AU2022263358A1 (en) 2021-04-21 2023-11-30 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of heart failure

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WO1996010996A1 (en) * 1993-07-21 1996-04-18 The University Of Kentucky Research Foundation A multicompartment hard capsule with control release properties
WO2005013940A1 (en) * 2003-08-06 2005-02-17 Galephar M/F Stable controlled release pharmaceutical compositions containing fenofibrate and pravastatin
WO2006017692A2 (en) * 2004-08-06 2006-02-16 Transform Pharmaceuticals, Inc. Novel fenofibrate formulations and related methods of treatment
WO2007011886A2 (en) * 2005-07-18 2007-01-25 Reliant Pharmaceuticals, Inc. Treatment with azetidinone-based cholesterol absorption inhibitors and omega-3 fatty acids and a combination product thereof
WO2007016256A2 (en) * 2005-07-28 2007-02-08 Reliant Pharmaceuticals, Inc. Treatment with dihydropyridine calcium channel blockers and omega-3 fatty acids and a combination product thereof

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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996010996A1 (en) * 1993-07-21 1996-04-18 The University Of Kentucky Research Foundation A multicompartment hard capsule with control release properties
WO2005013940A1 (en) * 2003-08-06 2005-02-17 Galephar M/F Stable controlled release pharmaceutical compositions containing fenofibrate and pravastatin
WO2006017692A2 (en) * 2004-08-06 2006-02-16 Transform Pharmaceuticals, Inc. Novel fenofibrate formulations and related methods of treatment
WO2007011886A2 (en) * 2005-07-18 2007-01-25 Reliant Pharmaceuticals, Inc. Treatment with azetidinone-based cholesterol absorption inhibitors and omega-3 fatty acids and a combination product thereof
WO2007016256A2 (en) * 2005-07-28 2007-02-08 Reliant Pharmaceuticals, Inc. Treatment with dihydropyridine calcium channel blockers and omega-3 fatty acids and a combination product thereof

Non-Patent Citations (1)

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Title
See also references of WO2007103557A2 *

Also Published As

Publication number Publication date
WO2007103557A2 (en) 2007-09-13
JP5628480B2 (en) 2014-11-19
EP2081550B1 (en) 2018-04-18
EP2081550B2 (en) 2021-05-26
JP2009529531A (en) 2009-08-20
EP2081550A2 (en) 2009-07-29
WO2007103557A3 (en) 2008-11-20

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