EP2079846A4 - Gezielte glycosaminoglycan-polymere durch polymer-grafting und herstellungs- und anwendungsverfahren dafür - Google Patents

Gezielte glycosaminoglycan-polymere durch polymer-grafting und herstellungs- und anwendungsverfahren dafür

Info

Publication number
EP2079846A4
EP2079846A4 EP07874512.2A EP07874512A EP2079846A4 EP 2079846 A4 EP2079846 A4 EP 2079846A4 EP 07874512 A EP07874512 A EP 07874512A EP 2079846 A4 EP2079846 A4 EP 2079846A4
Authority
EP
European Patent Office
Prior art keywords
making
methods
same
polymer grafting
glycosaminoglycan polymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07874512.2A
Other languages
English (en)
French (fr)
Other versions
EP2079846A2 (de
Inventor
Paul L Deangelis
Alison Sismey-Ragatz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Oklahoma
Original Assignee
University of Oklahoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Oklahoma filed Critical University of Oklahoma
Priority to EP13189930.4A priority Critical patent/EP2690178B1/de
Publication of EP2079846A2 publication Critical patent/EP2079846A2/de
Publication of EP2079846A4 publication Critical patent/EP2079846A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP07874512.2A 2006-10-03 2007-10-03 Gezielte glycosaminoglycan-polymere durch polymer-grafting und herstellungs- und anwendungsverfahren dafür Withdrawn EP2079846A4 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP13189930.4A EP2690178B1 (de) 2006-10-03 2007-10-03 Gezielte Glycosaminoglycanpolymere durch Polymerpfropfung und Verfahren zur Herstellung und Verwendung davon

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84903406P 2006-10-03 2006-10-03
US92129607P 2007-03-30 2007-03-30
PCT/US2007/021213 WO2008130373A2 (en) 2006-10-03 2007-10-03 Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP13189930.4A Division EP2690178B1 (de) 2006-10-03 2007-10-03 Gezielte Glycosaminoglycanpolymere durch Polymerpfropfung und Verfahren zur Herstellung und Verwendung davon

Publications (2)

Publication Number Publication Date
EP2079846A2 EP2079846A2 (de) 2009-07-22
EP2079846A4 true EP2079846A4 (de) 2013-08-07

Family

ID=39876092

Family Applications (2)

Application Number Title Priority Date Filing Date
EP07874512.2A Withdrawn EP2079846A4 (de) 2006-10-03 2007-10-03 Gezielte glycosaminoglycan-polymere durch polymer-grafting und herstellungs- und anwendungsverfahren dafür
EP13189930.4A Active EP2690178B1 (de) 2006-10-03 2007-10-03 Gezielte Glycosaminoglycanpolymere durch Polymerpfropfung und Verfahren zur Herstellung und Verwendung davon

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP13189930.4A Active EP2690178B1 (de) 2006-10-03 2007-10-03 Gezielte Glycosaminoglycanpolymere durch Polymerpfropfung und Verfahren zur Herstellung und Verwendung davon

Country Status (4)

Country Link
EP (2) EP2079846A4 (de)
AU (1) AU2007351891A1 (de)
CA (1) CA2701601C (de)
WO (1) WO2008130373A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012021995A8 (pt) 2010-03-01 2018-01-02 Dsm Ip Assets Bv Composição,célula hospedeira bacteriana não patogênica, método para a produção de um sulfato de condroitina,condroitina, composição e anticorpo ou fragmento de anticorpo

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH624011A5 (de) 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4708861A (en) 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
US7223571B2 (en) * 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20060105431A1 (en) * 1998-11-11 2006-05-18 Deangelis Paul L Polymer grafting by polysaccharide synthases using artificial sugar acceptors
WO2002088115A1 (en) 2001-04-26 2002-11-07 Kolon Ind. Inc. Novel sulfonamide derivatives, intermediate thereof, its preparation methods, and pharmaceutical composition comprising the same
US20060009409A1 (en) * 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
JP5027387B2 (ja) * 2002-07-01 2012-09-19 タフツ・ユニバーシティ ヒアルロナンオリゴマーにより多剤耐性を阻害する方法及び組成物
WO2006033693A2 (en) * 2004-06-30 2006-03-30 Deangelis Paul L Methods of selectively treating diseases with specific glycosaminoglycan polymers

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DEMCHENKO (EDITOR): "Fronteirs in Modern Carbohydrate Chemistry / ACS Symposium Series", vol. 960, 13 March 2007, ACS, article AVCI ET AL: "Enzymatic synthesis of glycosaminoglycans: Improving on nature", pages: 253 - 284, XP002699118 *
JING ET AL: "Defined megadalton hyaluronan polymer standards", ANALYTICAL BIOCHEMISTRY, vol. 355, 23 June 2006 (2006-06-23), pages 183 - 188, XP024942078 *
KAMERLING (EDITOR-IN-CHIEF): "Comprehensive Glycoscience", vol. 3, 2007, ELSEVIER, ISBN: 978-0-4445-2746-2, article DEANGELIS: "Hyaluronan biosynthesis systems from microbes to man", pages: 325 - 341, XP002699207 *
KANE ET AL: "Functional characterization of PmHS1, a Pasteurella multocida heparosan synthase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, 7 September 2006 (2006-09-07), pages 33192 - 33197, XP002699111 *
LINHARDT ET AL: "Enzymatic synthesis of glycosaminoglycan heparin", SEMINARS IN THROMBOSIS AND HEMOSTASIS, vol. 33, July 2007 (2007-07-01), pages 453 - 465, XP008163151 *
PUMMILL ET AL: "The functional molecular mass of the Pasteurella hyaluronan synthase is a monomer", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1770, 4 October 2006 (2006-10-04), pages 286 - 290, XP005818421 *
SISMEY-RAGATZ ET AL: "Chemoenzymatic synthesis with distinct Pasteurella heparosan synthases", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, 11 July 2007 (2007-07-11), pages 28321 - 28327, XP002699113 *
TRACY ET AL: "Acceptor specificity of the Pasteurella hyaluronan and chondroitin synthases and production of chimeric glycosaminoglycans", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, 10 November 2006 (2006-11-10), pages 337 - 344, XP002699112 *
WILLIAMS ET AL: "Critical elements of oligosaccharide acceptor substrates for the Pasteurella multocida hyaluronan synthase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, 16 December 2005 (2005-12-16), pages 5391 - 5397, XP002482219 *

Also Published As

Publication number Publication date
CA2701601A1 (en) 2008-10-30
WO2008130373A3 (en) 2009-03-05
EP2690178B1 (de) 2021-12-22
CA2701601C (en) 2020-06-30
AU2007351891A1 (en) 2008-10-30
WO2008130373A2 (en) 2008-10-30
EP2690178A1 (de) 2014-01-29
EP2079846A2 (de) 2009-07-22

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Inventor name: SISMEY-RAGATZ, ALISON

Inventor name: DEANGELIS, PAUL, L.

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