EP2069015A2 - Lampe zur stimulierung der produktion von vitamin d und verfahren zu ihrer herstellung - Google Patents
Lampe zur stimulierung der produktion von vitamin d und verfahren zu ihrer herstellungInfo
- Publication number
- EP2069015A2 EP2069015A2 EP07837496A EP07837496A EP2069015A2 EP 2069015 A2 EP2069015 A2 EP 2069015A2 EP 07837496 A EP07837496 A EP 07837496A EP 07837496 A EP07837496 A EP 07837496A EP 2069015 A2 EP2069015 A2 EP 2069015A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- vitamin
- lamp
- production
- person
- photons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229940046008 vitamin d Drugs 0.000 title claims abstract description 44
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 23
- 230000004936 stimulating effect Effects 0.000 title claims abstract description 10
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 45
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 43
- 239000011710 vitamin D Substances 0.000 claims abstract description 43
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 43
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 41
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 claims abstract description 14
- 230000019612 pigmentation Effects 0.000 claims abstract description 8
- 238000007254 oxidation reaction Methods 0.000 claims abstract description 7
- 239000011248 coating agent Substances 0.000 claims description 10
- 238000000576 coating method Methods 0.000 claims description 10
- 230000005855 radiation Effects 0.000 claims description 10
- 230000004323 axial length Effects 0.000 claims description 3
- 102000008186 Collagen Human genes 0.000 abstract description 9
- 108010035532 Collagen Proteins 0.000 abstract description 9
- 229920001436 collagen Polymers 0.000 abstract description 9
- 239000011159 matrix material Substances 0.000 abstract description 8
- 210000000988 bone and bone Anatomy 0.000 abstract description 7
- 210000000845 cartilage Anatomy 0.000 abstract description 6
- 210000003491 skin Anatomy 0.000 abstract description 6
- 102000016942 Elastin Human genes 0.000 abstract description 4
- 108010014258 Elastin Proteins 0.000 abstract description 4
- 229920002549 elastin Polymers 0.000 abstract description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 21
- 238000001720 action spectrum Methods 0.000 description 16
- 238000001228 spectrum Methods 0.000 description 16
- 229940088594 vitamin Drugs 0.000 description 9
- 229930003231 vitamin Natural products 0.000 description 9
- 235000013343 vitamin Nutrition 0.000 description 9
- 239000011782 vitamin Substances 0.000 description 9
- 150000003722 vitamin derivatives Chemical class 0.000 description 9
- 230000003595 spectral effect Effects 0.000 description 6
- 239000011575 calcium Substances 0.000 description 5
- 238000010276 construction Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 4
- 230000036555 skin type Effects 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000036765 blood level Effects 0.000 description 3
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 3
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000003716 rejuvenation Effects 0.000 description 3
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 description 3
- 230000036561 sun exposure Effects 0.000 description 3
- 239000011647 vitamin D3 Substances 0.000 description 3
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 3
- GMRQFYUYWCNGIN-ZVUFCXRFSA-N 1,25-dihydroxy vitamin D3 Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-ZVUFCXRFSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 206010042496 Sunburn Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000007124 immune defense Effects 0.000 description 2
- 230000003308 immunostimulating effect Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- -1 pro-vitamin D Chemical class 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 235000005282 vitamin D3 Nutrition 0.000 description 2
- 229940021056 vitamin d3 Drugs 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 229910052775 Thulium Inorganic materials 0.000 description 1
- 230000037338 UVA radiation Effects 0.000 description 1
- 206010047626 Vitamin D Deficiency Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000018678 bone mineralization Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 229910052681 coesite Inorganic materials 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 229910052906 cristobalite Inorganic materials 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229910052682 stishovite Inorganic materials 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
- 235000019195 vitamin supplement Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 229910052882 wollastonite Inorganic materials 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J61/00—Gas-discharge or vapour-discharge lamps
- H01J61/70—Lamps with low-pressure unconstricted discharge having a cold pressure < 400 Torr
- H01J61/72—Lamps with low-pressure unconstricted discharge having a cold pressure < 400 Torr having a main light-emitting filling of easily vaporisable metal vapour, e.g. mercury
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
- C09K11/66—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing germanium, tin or lead
- C09K11/666—Aluminates; Silicates
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
- C09K11/66—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing germanium, tin or lead
- C09K11/667—Borates
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
- C09K11/70—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing phosphorus
- C09K11/71—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing phosphorus also containing alkaline earth metals
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
- C09K11/74—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing arsenic, antimony or bismuth
- C09K11/75—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing arsenic, antimony or bismuth containing antimony
- C09K11/76—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing arsenic, antimony or bismuth containing antimony also containing phosphorus and halogen, e.g. halophosphates
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
- C09K11/77—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals
- C09K11/7766—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals containing two or more rare earth metals
- C09K11/778—Borates
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
- C09K11/77—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals
- C09K11/7783—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals containing two or more rare earth metals one of which being europium
- C09K11/7794—Vanadates; Chromates; Molybdates; Tungstates
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
- C09K11/77—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals
- C09K11/7783—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals containing two or more rare earth metals one of which being europium
- C09K11/7795—Phosphates
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J61/00—Gas-discharge or vapour-discharge lamps
- H01J61/02—Details
- H01J61/38—Devices for influencing the colour or wavelength of the light
- H01J61/42—Devices for influencing the colour or wavelength of the light by transforming the wavelength of the light by luminescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0614—Tanning
- A61N2005/0615—Tanning using UV light sources having a specific spectrum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet
Definitions
- the present invention relates generally to discharge lamps that stimulate the production of vitamin D in a person exposed thereto, and more specifically, to discharge lamps which over a predetermine exposure period stimulate a person's production of vitamin D without causing significant facultative pigmentation or melanin oxidization. Moreover, the present invention is also directed to discharge lamps that in addition to stimulating a person's production of vitamin D, emit photons that rejuvenate the collagen/elastin matrix that supports the person's skin, cartilage and bone.
- vitamin D is considered to be a beneficial nutrient for bone-related conditions, such as rickets and osteoporosis. Additionally, it is now appreciated that diverse diseases including cancer, diabetes, multiple sclerosis, and coronary heart disease are also vitamin D mediated.
- Vitamin D is a nutrient most people get though exposure to sunlight.
- cholecalciferol (vitamin D 3 )
- cholecalciferol is processed by the liver to create 25-dihydroxyvitamin D 3 which is later transformed by the kidneys to 1,25 dihydroxyvitamin D 3 .
- the nutrient 1,25 dihydroxyvitamin D 3 is known to improve calcium absorption in the small intestines, improve urinary calcium re-absorption in the kidneys and improve bone mineralization.
- those at greatest risk of having too little vitamin D include: elderly people; babies who are exclusively breast-fed; people with dark skin (darker- skinned people need more sun exposure to produce vitamin D); people who don't get any sun exposure (those who are housebound or who cover their bodies with clothing for religious or cultural reasons); people who live in the northern U.S. and Canada (e.g., above 37 degrees latitude) during the winter.
- the vitamin D-effective photons packets of light energy
- photons packets of light energy
- i.e., those responsible for stimulating the cutaneous production of pro-vitamin D are found in the wavelengths between 250 nm and 320 nm, with 296 nm being the "peak" wavelength.
- the utility of the action spectra illustrated in Fig. 1 will be discuss in more detail hereinbelow.
- vitamin D occurs naturally in only a few food products and is added to just a handful of others, many experts worry that Americans get too little vitamin D to reap these potential benefits. Yet few are willing to encourage sun exposure with its well-known dangers and therefore, advocated vitamin supplements as a means for addressing vitamin D deficiencies.
- UVR producing lamps emit a spectrum of ultraviolet light which is similar to that of the sun.
- the sun emits three kinds of ultraviolet (UV) rays, UVA, UVB and UVC.
- UVC at 100 nanometers (nm) to 280 nm, is the shortest and widely considered to be the most harmful wavelength of UV rays, but it is virtually blocked by the Earth's ozone layer and pollution.
- UVB is the medium wavelength, from 280- 320 nm, and although overexposure to UVB has been found to cause erythema (sunburn), a controlled amount is necessary to initiate tanning in the skin.
- UVA is the longest wavelength, from 320-400 nm, and has been found to be responsible for the completion of the tanning process (i.e., via oxidation or darkening of the pigment (melanin), as discussed in further detail herein).
- Short-wavelength UVB (280-315 nm) has been recognized for some time as carcinogenic in experimental animals, and there is some evidence that longer-wavelength UVA (315-400 nm), which penetrates more deeply into the skin, also contributes to the induction of cancer.
- the beneficial wavelengths i.e., those that stimulate the production of vitamin D
- the harmful wavelengths hose that damage the skin and cause Cutaneous Malignant Melanoma (CMM) are found so close together that the electromagnetic spectrum has been described as "Mother Nature's little joke.”
- dermatologist have resisted recommending any exposure to sunlight or UVR due to their position that UVR induces CMM.
- the wavelengths associated with the biological reactions that stimulate the production of these protein are found between 580nm and 680nm and these wavelengths are also immunostimulatory (i.e., they stimulate our immune defense system).
- a discharge lamp adapted for stimulating the production of vitamin D in human skin being exposed thereto, and more specifically, to discharge lamps which over a predetermine exposure period stimulate the production of Vitamin D without causing significant oxidation of a melanin or facultative pigmentation.
- a novel discharge lamp that in addition to stimulating a person's production of vitamin D, emits photons that rejuvenate the collagen/elastin matrix that supports the person's skin, cartilage and bone.
- the subject invention is directed to new and useful discharge lamps that solve the problems described above.
- the present invention relates generally to mercury vapor discharge lamps of the fluorescent type having a particular phosphor coating(s) that is/are adapted to emit radiation having a preferred spectra when excited by the UV radiation generated from the mercury vapor discharge.
- Lamps constructed in accordance with the present disclosure stimulate the production of Vitamin D without causing significant oxidation of a melanin or facultative pigmentation.
- the present invention is also directed to lamps for stimulating vitamin
- An embodiment of the novel lamp construction disclosed herein includes, inter alia, a vitreous tube having an outer periphery and axially opposed first and second ends which define an axial length for the tube therebetween.
- the lamp further includes a first electrode assembly associated with the first end of the tube and a second electrode assembly associated with the second end of the tube.
- a coating is applied on an interior of the tube which is adapted for delivering an effective dose of vitamin D photons to a person's skin during a predetermined exposure period, wherein the coating delivers an insufficient amount of UVB and UVA photons during the exposure period to cause significant facultative pigmentation and/or melanin oxidization.
- the lamp of the present invention does not need to be elongated or axial in construction and can be formed in various shapes and sizes, such as circular or U-shaped, without departing from the inventive aspects of the present disclosure.
- the exposure time required to deliver an effecting dose of vitamin D photons to a person's skin is less than T e and T m .
- the ultraviolet radiation emitted from the lamp in a range of about 320 nm to about 340 nm is less than or equal to about 10 percent of the ultraviolet radiation emitted from the lamp in a range of about 280 nm to about 400 nm.
- the lamp of the present invention is adapted for stimulating the production of collagen through emission of optimal energy in the 580nm to 680nm wavelengths.
- the phosphor coating is also adapted for emitting photons that rejuvenate the collagen/elastin matrix that supports the person's skin, cartilage and bone.
- the lamp of the present invention emits energy having a peak spectrum of 296 nm and a band with of 5nm.
- Fig. 1 is a graphical comparison of two vitamin D-effective action spectra that illustrates a peak wavelength for both spectra occurring at 296nm;
- Fig. 2 is a graphical comparison of the spectral distribution for three
- UVR sources
- Fig. 3 provides a graphical representation of the an action spectrum for skin rejuvenation
- Figs. 4a-4f provides in tabular form the irradiance data for the Vitamin
- Exemplary lamps constructed in accordance with the present invention provide a controlled amount of UVB radiation in the approximate 280 nm to 320 nm UV region of the spectrum, dramatically reduce the amount of UVA radiation in the approximate 340 nm to 400 nm UV region of the spectrum (hereinafter referred to as being "UVAl”), and virtually eliminate the amount of UV radiation in the approximate 320 nm to 340 nm UV region of the spectrum (hereinafter referred to as being "UVA2”) in comparison with prior UVR emitting discharge lamps.
- UVAl the amount of UVA radiation in the approximate 280 nm to 320 nm UV region of the spectrum
- UVA2 virtually eliminate the amount of UV radiation in the approximate 320 nm to 340 nm UV region of the spectrum
- Lamps constructed in accordance with the teachings of the present invention provide light of an appropriate spectrum to induce the production of Vitamin D in the skin of the person being exposed to the light source.
- Light between the wavelengths of 250 and 320 nm and particularly between 290 and 310 nm are those that stimulate the production of vitamin D in the skin. (See Fig. 1) This is also in the part of the spectrum that causes the skin to redden and sunburn so it is essential that the exposure be controlled.
- a pure UVB phosphor were used in this application the person being exposed to the light would be overexposed in a matter of seconds.
- the UVB phosphor is diluted with a non-UV emitting substance, such as a phosphor that gives off only visible light.
- the UVAl (340 - 400 nm) photons are be kept to a minimum and the UV A2 (320 - 340 nm) kept near zero.
- the phosphor combination has a peak spectrum of 296 nm and have a total band width of five nanometers and a visible phosphor that has no output below 420 nm.
- lamps which achieve the desired spectral characteristics have been constructed using (Ca 5 Zn) 3 (PO 4 ) ⁇ Tl (NP803) as the UVB source and Ca 5 (F,CL)(PO 4 ) 3 :Sb:Mn (Cool White and Daylight) or (Sr 5 Mg) 3 (PO 4 ): Sn (Type 283) as the visible source.
- the redder phosphors give better results because they have no output below 420 nm.
- the NP803 peaks at 319 nm which is really too high but this phosphor has a tail that reaches below 290 nm so it has an output in the desired range of 290 to 310 nm.
- UVB phosphors that work well in this application are MgSrAl ⁇ Oi 7 :Ce (Type 2096), Sr(BO 2 ) 6 :Pb (Type 2061) or (Ba,Zn,Mg)SiO 2 :Pb (Type 2071).
- the visible phosphor does not have an output below 420nm.
- Another criterion is that the visible phosphor must have little or no absorption above 290nm.
- red phosphors are best suited for these applications, such as Y(P,V)O 4 :Eu (NP310), Gd(Zn,Mg)B 5 Oi 0 :Ce,Mn (L165), (Sr 5 Mg) 3 (PO 4 ): Sn (Type 283), CaSiO 3 :Pb,Mn (Type 290C), (Sr,Mg) 3 (PO4) 2 :Sn (Type 282), Ca 5 (F,CL)(PO 4 ) 3 :Sb:Mn (Type 4300).
- the ratio of visible light emitting phosphor to UVB emitting phosphor is 93:7
- the ratio can be 92.5:7.5 (e.g. Warm White phosphor (Type 4300 - NP803), or 76:24 (e.g., Orange (Type 283 - NP803)).
- the amount of non-UV or visible light emitting phosphor added to the phosphor composition is based on the particular UVB emitting phosphor used and the proportions are adjusted in order to achieve the desired spectral irradiance for the lamp.
- Fig. 2 provides a graphical comparison of the spectral distribution patterns of three UVR sources; a lamp constructed in accordance with the teachings of the present application (identified as, "Rxd-Orange”); a traditional IOOW sunlamp and natural sunlight at noon on a typical Midwestern summer day.
- the phosphors used in the Rxd-Orange lamp have shifted a large portion of the photons to the left in the irradiance spectrum (to a lower wavelength) and into the vitamin D target range (i.e., Region 1: 250 nm to 320nm).
- the tanning photons (Region 2: 340nm to 430nm) that are typically within the Region 2 on the graph, have been virtually eliminated.
- Table 2 below compares the UV irradiance data of the RxD lamp to a traditional sunlamp, identified as "GTX65 Blue.”
- a larger percentage of the total UV irradiance UVA & UVB
- UVA & UVB percentage of UV irradiance
- the RxD(orange) sunlamp shows an increase in vitamin D-eff photons of 122% and 330% over sunlight at noon on a typical Midwestern summer day.
- the tanning power the RxD sunlamp, reduces the tanning power by 91.5% as compared to traditional sunlamps and by 87.2% as compared to sunlight.
- the RxD lamp is more efficient stimulator of vitamin D then either of the other sources and has virtually removed all of the photons associated with facultative pigmentation.
- Te and Tt-eff are calculated. More specifically, skilled artisans in the field of UV discharge lamps will readily understand how the "source" readings/spectral irradiance for a discharge lamp, measured for example by a scanning double-beam spectroradiaometer, are converted into Te and Tt-eff. The vitamin D effective (vD-eff) value is determined in a similar manner.
- the irradiance at each wavelength is multiplied by a corresponding weighing factor provided by the appropriate action spectrum, such as Fig. 1 for vitamin D stimulation and Fig. 3 for collagen rejuvenation, to determine "weighted” or "effective” values.
- a corresponding weighing factor provided by the appropriate action spectrum, such as Fig. 1 for vitamin D stimulation and Fig. 3 for collagen rejuvenation, to determine "weighted” or "effective” values.
- a total effective irradiance is obtained through integration of the data using the FDA EAS formula.
- UVB (280-320nm) 0.0003048 0.000535 0.0002206
- UVA (320-400nm) 0.0006499 0.0144104 0.0040635
- UVA1 (340-400nm) 0.0003833 0.01 15042 0.0033147
- UVA2 (320-340nm) 0.0002666 0.0029062 0.0007488
- UVA (320-400nm) 68.1 96.4 94.9
- UVA1 (340-400nm) 40.1 77 77.4
- UVA2 (320-340nm) 27.9 19.5 17.5
- UVI Ultraviolet Index
- the total irradiance in the UVAAJVB range for RxD lamp is much less than the other two sources and many of the photons that would normally be found in the UVAl and UV A2 ranges have been shifted into the UVB range.
- vitamin D-effective When we speak of a "vitamin D-effective" (usually shortened to vitamin D-eff or vD-eff) dose, we are referring to a level (Wm ⁇ 2 or mW/m'2) that is determined after the "source (i.e., sunlight or a sunlamp) irradiance (that has been determined by a scanning double beam spectroradiometer such as our Optronics Laboratory 752/754/756 has been convoluted (i.e., multiplied by) with a vitamin D AS (action spectrum).
- source i.e., sunlight or a sunlamp
- the SPI action spectrum results in a more conservative exposure time, thus reducing the chance of any ill effects on the person exposed to the lamp.
- the wavelengths associated with the biological reactions that stimulate the production of collagen and elastogen i.e., the proteins that provide the "matrix" that supports our skin, cartilage and bones (that makes possible younger looking skin) and that breaks down as we age are found between 580 nm and 680 nm. (See Fig. 3) and these wavelengths are also immunostimulatory (i.e., they stimulate our immune defense system).
- the present inventors have added a phosphor to the phosphor blend in certain embodiments which emits photons in the 580 nm and 680 nm range, (e.g. Osram Type 283, Type 290 & Type L 165 or Nichia NP310).
- a phosphor to the phosphor blend in certain embodiments which emits photons in the 580 nm and 680 nm range, (e.g. Osram Type 283, Type 290 & Type L 165 or Nichia NP310).
- the elongated tubes used the present invention are filled with a rare gas, such as argon, and a drop of mercury.
- the vitreous tubes can have an outer periphery which is smooth or include a helical groove path formed therein over at least a portion of its axial length, similar to the lamps disclosed in U.S. Patent Nos. 6,943,361 and 6,777,702, which are herein incorporated by reference in their entirety.
- the phosphor coating can be applied to the lamp in a single coating with the desired chemical composition or a multi-layer coating, as know to those skilled in the art. Additionally, the coating(s) can be applied along the entire length of the lamp or over a portion of the length, as described in U.S.
- Patent 6,919,676 which is herein incorporated by reference in its entirety.
Landscapes
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Radiation-Therapy Devices (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84161506P | 2006-08-31 | 2006-08-31 | |
PCT/US2007/019010 WO2008027438A2 (en) | 2006-08-31 | 2007-08-29 | Lamp for stimulating vitamin d production and method of making the same |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2069015A2 true EP2069015A2 (de) | 2009-06-17 |
Family
ID=39136566
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07837496A Withdrawn EP2069015A2 (de) | 2006-08-31 | 2007-08-29 | Lampe zur stimulierung der produktion von vitamin d und verfahren zu ihrer herstellung |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2069015A2 (de) |
WO (1) | WO2008027438A2 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010016009A1 (en) * | 2008-08-07 | 2010-02-11 | Koninklijke Philips Electronics N.V. | Ultra-violet and visible light emitting system |
DK2500060T3 (en) | 2011-03-17 | 2016-12-19 | Jk-Holding Gmbh | An apparatus for irradiation with actinic radiation of different wavelengths |
EP2573799A1 (de) * | 2011-09-21 | 2013-03-27 | SRLight ApS | Vorrichtung zur Förderung der Produktion von Vitamin D in einem lebenden Organismus |
KR101322658B1 (ko) * | 2011-11-24 | 2013-10-30 | 주식회사 루트로닉 | 의료용 레이저 치료장치 |
WO2013103743A1 (en) * | 2012-01-03 | 2013-07-11 | Moffat William A | Phototherapeutic apparatus for focused uvb radiation and vitamin d synthesis and associated systems and methods |
CA2928723A1 (en) | 2013-10-25 | 2015-04-30 | Benesol, Inc. | Systems and methods for increased vitamin d3 production |
CN105470069B (zh) * | 2015-10-23 | 2017-10-17 | 东台市天源荧光材料有限公司 | 一种uvb太阳光补钙荧光灯的制备方法 |
US20200391049A1 (en) | 2017-12-15 | 2020-12-17 | Benesol, Inc. | Systems and methods for operating phototherapy kiosks |
US11350496B2 (en) | 2019-02-19 | 2022-05-31 | Seoul Semiconductor Co., Ltd. | LED lighting apparatus and lighting system having the same |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2609273A1 (de) * | 1976-03-05 | 1977-09-08 | Mutzhas Maximilian F | Bestrahlungseinrichtung mit ultraviolett-strahlenquelle |
US6447537B1 (en) * | 2000-06-21 | 2002-09-10 | Raymond A. Hartman | Targeted UV phototherapy apparatus and method |
US7144248B2 (en) * | 2001-10-18 | 2006-12-05 | Irwin Dean S | Device for oral UV photo-therapy |
JP2003194721A (ja) * | 2001-12-26 | 2003-07-09 | Nec Lighting Ltd | 蛍光トランスイルミネーター |
-
2007
- 2007-08-29 EP EP07837496A patent/EP2069015A2/de not_active Withdrawn
- 2007-08-29 WO PCT/US2007/019010 patent/WO2008027438A2/en active Application Filing
Non-Patent Citations (1)
Title |
---|
See references of WO2008027438A3 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008027438A3 (en) | 2008-06-19 |
WO2008027438A2 (en) | 2008-03-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2069015A2 (de) | Lampe zur stimulierung der produktion von vitamin d und verfahren zu ihrer herstellung | |
EP2968972B1 (de) | Quantenpunkt-leuchtdioden für eine lichttherapie | |
US3670193A (en) | Electric lamps producing energy in the visible and ultra-violet ranges | |
EP1970423A1 (de) | Leuchtstofflampe zur Anregung der Bildung von Prävitamin D3 | |
EP2164566B1 (de) | Hautbehandlungsvorrichtung, lampe | |
Willis et al. | The rapid induction of cancers in the hairless mouse utilizing the principle of photoaugmentation | |
Diffey | Ultraviolet radiation physics and the skin | |
US4959551A (en) | Cosmetic tanning lamp and system having adjustable UVB proportion | |
US20080039907A1 (en) | Phototherapy Systems and Methods | |
NO852864L (no) | Lysstofflampe. | |
Morita et al. | Short-range ultraviolet irradiation with LED device effectively increases serum levels of 25 (OH) D | |
Hemne et al. | Phosphor for phototherapy: review on psoriasis | |
National Toxicology Program | Ultraviolet-radiation-related exposures | |
EP1523760B1 (de) | Bräunungsgerät | |
Belsare et al. | Preparation and characterization of uv emitting fluoride phosphors for phototherapy lamps | |
EP2023374A2 (de) | UV-Bräunungslampe mit gesteuerter Bestrahlung | |
EP3456380A1 (de) | Zur aussendung von strahlung im uv-b-wellenlängenbereich fähiges material | |
US20080255547A1 (en) | Uv Lamp for Treatment of the Skin | |
Farr et al. | Phototherapy and dithranol treatment of psoriasis: new lamps for old. | |
Jekler et al. | Ultraviolet radiation dosimetry in phototherapy for atopic dermatitis | |
McKenzie et al. | Sunburn versus vitamin D induced by UV from solaria and sunlight in New Zealand | |
Coblentz | The physical aspects of ultraviolet therapy | |
JPS63136457A (ja) | 健康増進用蛍光ランプ | |
Wanmaker et al. | New blue lamp for phototherapy of hyperbilirubinemia | |
WO2023244558A1 (en) | Ultraviolet b lighting system and method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20090227 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA HR MK RS |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: BATCHOS, DENNIS L. |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20110201 |