EP2061498A2 - Compositions et procédés de prévention du cancer avec des cupredoxines - Google Patents

Compositions et procédés de prévention du cancer avec des cupredoxines

Info

Publication number
EP2061498A2
EP2061498A2 EP07842403A EP07842403A EP2061498A2 EP 2061498 A2 EP2061498 A2 EP 2061498A2 EP 07842403 A EP07842403 A EP 07842403A EP 07842403 A EP07842403 A EP 07842403A EP 2061498 A2 EP2061498 A2 EP 2061498A2
Authority
EP
European Patent Office
Prior art keywords
cupredoxin
peptide
azurin
cancer
residues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07842403A
Other languages
German (de)
English (en)
Other versions
EP2061498A4 (fr
Inventor
Tapas Das Gupta
Ananda Chakrabarty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois
Original Assignee
University of Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois filed Critical University of Illinois
Publication of EP2061498A2 publication Critical patent/EP2061498A2/fr
Publication of EP2061498A4 publication Critical patent/EP2061498A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/104—Pseudomonadales, e.g. Pseudomonas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La présente invention concerne des compositions constituées de peptides pouvant être des variantes, des dérivés et des équivalents structurels des cupredoxines qui inhibent le développement de lésions prémalignes dans des cellules, des tissus et des animaux mammaliens. De manière spécifique, ces compositions peuvent contenir de l'azurine de Pseudomonas aeruginosa, et/ou la région résiduelle 50-77 de l'azurine (p28). La présente invention concerne en outre des compositions qui peuvent contenir une ou plusieurs cupredoxines, et/ou des variantes, des dérivés ou des équivalents structurels des cupredoxines et peuvent conserver la capacité d'inhiber le développement de lésions prémalignes dans des cellules, des tissus ou des animaux mammaliens. Ces compositions peuvent, entre autres, être des peptides ou des compositions pharmaceutiques. Il est possible d'utiliser les compositions de l'invention pour prévenir le développement de lésions prémalignes dans des cellules, des tissus et des animaux mammaliens, et de ce fait prévenir le cancer.
EP07842403A 2006-09-14 2007-09-13 Compositions et procédés de prévention du cancer avec des cupredoxines Withdrawn EP2061498A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84435806P 2006-09-14 2006-09-14
PCT/US2007/078371 WO2008033987A2 (fr) 2006-09-14 2007-09-13 Compositions et procédés de prévention du cancer avec des cupredoxines

Publications (2)

Publication Number Publication Date
EP2061498A2 true EP2061498A2 (fr) 2009-05-27
EP2061498A4 EP2061498A4 (fr) 2009-11-04

Family

ID=39184582

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07842403A Withdrawn EP2061498A4 (fr) 2006-09-14 2007-09-13 Compositions et procédés de prévention du cancer avec des cupredoxines

Country Status (13)

Country Link
EP (1) EP2061498A4 (fr)
JP (2) JP2010503409A (fr)
KR (1) KR20090059152A (fr)
CN (1) CN101595124A (fr)
AU (1) AU2007296429A1 (fr)
BR (1) BRPI0714987A2 (fr)
CA (1) CA2663498A1 (fr)
IL (1) IL197602A0 (fr)
MX (1) MX2009002787A (fr)
NO (1) NO20091267L (fr)
RU (1) RU2009113812A (fr)
SG (1) SG174784A1 (fr)
WO (1) WO2008033987A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9096663B2 (en) 2001-02-15 2015-08-04 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating conditions related to ephrin signaling with cupredoxins and mutants thereof
US7691383B2 (en) 2004-10-07 2010-04-06 The Board Of Trustees Of The University Of Illinois Cupredoxin derived transport agents and methods of use thereof
US7556810B2 (en) 2005-07-19 2009-07-07 The Board Of Trustees Of The University Of Ilinois Compositions and methods to control angiogenesis with cupredoxins
US7381701B2 (en) 2001-02-15 2008-06-03 The Borad Of Trustees Of The University Of Illinois Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
US10675326B2 (en) 2004-10-07 2020-06-09 The Board Of Trustees Of The University Of Illinois Compositions comprising cupredoxins for treating cancer
US9598470B2 (en) * 2004-10-07 2017-03-21 Craig W. Beattie Compositions and methods to prevent cancer by stabilizing P53 through non MDM2-mediated pathways
US9434770B2 (en) 2004-10-07 2016-09-06 Tapas K Das Gupta Modified cupredoxin derived peptides
US9968685B2 (en) 2004-10-07 2018-05-15 Brad N. Taylor Methods to treat cancer with cupredoxins
AU2006269879A1 (en) 2005-07-19 2007-01-25 The Board Of Trustees Of The University Of Illinois Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof
BRPI0718360A2 (pt) 2006-12-04 2013-11-12 Univ Illinois "composições e métodos para o tratamento do câncer com cupredoxinas e dna rico em cpg"
WO2008098216A2 (fr) 2007-02-08 2008-08-14 The Board Of Trustees Of The University Of Illinois Compositions et procédés destinés à prévenir le cancer avec des cupredoxines
EP3688194A1 (fr) * 2017-09-29 2020-08-05 Oncgnostics GmbH Détermination du risque de néoplasie et de cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1506375A (zh) * 2002-12-12 2004-06-23 浙江养生堂天然药物研究所有限公司 具有广谱抗肿瘤作用的细菌蛋白天青蛋白及其用途和含有其的药物组合物
US20060149037A1 (en) * 2004-10-07 2006-07-06 Ananda Chakrabarty Cupredoxin derived transport agents and methods of use thereof
WO2007018671A2 (fr) * 2005-05-20 2007-02-15 The Board Of Trustees Of The University Of Illinois Compositions et methodes de traitement d'etats associes a la signalisation de l'ephrine au moyen de cupredoxines
WO2007024368A2 (fr) * 2005-07-19 2007-03-01 The Board Of Trustees Of The University Of Illinois Compositions et methodes de controle de angiogenese a l'aide de cupredoxines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7491394B2 (en) * 2001-02-15 2009-02-17 The Board Of Trustees Of The University Of Illinois Cytotoxic factors for modulating cell death

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1506375A (zh) * 2002-12-12 2004-06-23 浙江养生堂天然药物研究所有限公司 具有广谱抗肿瘤作用的细菌蛋白天青蛋白及其用途和含有其的药物组合物
US20060149037A1 (en) * 2004-10-07 2006-07-06 Ananda Chakrabarty Cupredoxin derived transport agents and methods of use thereof
WO2007018671A2 (fr) * 2005-05-20 2007-02-15 The Board Of Trustees Of The University Of Illinois Compositions et methodes de traitement d'etats associes a la signalisation de l'ephrine au moyen de cupredoxines
WO2007024368A2 (fr) * 2005-07-19 2007-03-01 The Board Of Trustees Of The University Of Illinois Compositions et methodes de controle de angiogenese a l'aide de cupredoxines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PUNJ V ET AL: "Bacterial cupredoxin axurin as an inducer of apoptosis and regression in human breast cancer" ONCOGENE, NATURE PUBLISHING GROUP, GB BASINGSTOKE, HANTS, vol. 23, 1 January 2004 (2004-01-01), pages 2367-2378, XP003018759 ISSN: 0950-9232 *
See also references of WO2008033987A2 *

Also Published As

Publication number Publication date
JP2014050390A (ja) 2014-03-20
CA2663498A1 (fr) 2008-03-20
BRPI0714987A2 (pt) 2013-07-30
WO2008033987A2 (fr) 2008-03-20
RU2009113812A (ru) 2010-10-20
MX2009002787A (es) 2009-08-27
CN101595124A (zh) 2009-12-02
EP2061498A4 (fr) 2009-11-04
AU2007296429A1 (en) 2008-03-20
NO20091267L (no) 2009-06-04
JP2010503409A (ja) 2010-02-04
IL197602A0 (en) 2011-08-01
KR20090059152A (ko) 2009-06-10
SG174784A1 (en) 2011-10-28
WO2008033987A3 (fr) 2009-04-30

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US10086037B2 (en) Compositions and methods to prevent cancer with cupredoxins
EP1653990B1 (fr) Utilisation de polypeptides de la famille des cupredoxines dans la therapie du cancer
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