EP2029100A2 - Comprimé plat combiné ache-nmda - Google Patents

Comprimé plat combiné ache-nmda

Info

Publication number
EP2029100A2
EP2029100A2 EP07725819A EP07725819A EP2029100A2 EP 2029100 A2 EP2029100 A2 EP 2029100A2 EP 07725819 A EP07725819 A EP 07725819A EP 07725819 A EP07725819 A EP 07725819A EP 2029100 A2 EP2029100 A2 EP 2029100A2
Authority
EP
European Patent Office
Prior art keywords
preparation according
dementia
active
active ingredients
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07725819A
Other languages
German (de)
English (en)
Inventor
Hans-Rainer Hoffmann
Reto BRÄNDLI
Frank Theobald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Publication of EP2029100A2 publication Critical patent/EP2029100A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Definitions

  • the present invention relates to a sheet-like, quickly disintegrating on contact with moisture, pharmaceutical preparation based on hydrophilic polymers for the treatment of dementia, wherein the dosage form contains a drug combination of at least two active ingredients which are suitable for the treatment of dementias (anti-dementia).
  • the invention further relates to the use of such an active substance combination for the production of an orally administrable medicament for the treatment of dementia diseases such as Alzheimer's disease, and to a process for the symptomatic treatment of Alzheimer's disease by oral administration of one of the medicament formulations mentioned.
  • Alzheimer's is currently the most common form of dementia, with dementia being understood as the loss of intellectual functions such as thinking, remembering, and associating mental contents that go so far that actions and processes of daily life can no longer be carried out independently. In the terminal stage, dementia can also lead to death.
  • Alzheimer's disease is defined in the literature as a progressive, degenerative disease of the CNS associated with impaired memory, intelligence, and behavior, with memory loss not only personal memories but also elemental actions such as food intake, spatial orientation , basic vocabulary and the like.
  • impaired memory is a disorder of the neurotransmitters glutamate and acetylcholine.
  • Alzheimer's Disease As with all dementias, Alzheimer's Disease, or Alzheimer's disease for short (Alzheimer's disease), with its increasing average age, causes an increasing number of patients in need of treatment.
  • the treatment should improve, or at least stabilize, and delay the decline in mental capacity.
  • a corresponding drug therapy is required.
  • advanced dementia the preservation of the everyday competence of the patient and a delay in the need for care or home admission are ultimately the focus of therapy.
  • NMDA neuroprotective NMDA
  • Antagonists N-methyl-D-aspartic acid
  • Memantine prevents the absorption of glutamate at the NMDA receptors, so that the permanent irritation overload is reduced and signals in the conduction can be recognized again.
  • the cell death of nerve cells due to permanent overload can be prevented or delayed in this way.
  • the patients become mentally active again and everyday life is increasing. Visible improvements can also be detected in patients who are already in need of care.
  • AchE inhibitors acetylcholinesterase inhibitors
  • AchE Ace- tylcholinesterase inhibitors
  • the therapy is further complicated by the fact that often not only a drug is given in the therapy, but often a combination of different drugs is used. Each additional drug increases but the Danger that his intake, in addition to often other required drugs that must take the usually older patients, forgotten and omitted. In addition, as the number of tablets to be taken increases, the reluctance to ingest often increases, thus decreasing patient compliance.
  • the object underlying the invention was therefore to provide pharmaceutical preparations with which a combination therapy for the symptomatic treatment of Alzheimer's can be carried out in a simple and safe manner, and which make it possible to avoid or reduce the abovementioned disadvantages.
  • the invention was also based on the object of demonstrating methods for the drug combination therapy of dementia dementia.
  • Typical administration forms for administering active substances in therapy are tablets or capsules.
  • buccal or sublingual tablets which release the active ingredient in the oral cavity, so that it can be absorbed directly through the oral mucosa.
  • the disadvantage of these tablets is an often unpleasant mouthfeel and, due to their compact form, only a slow disintegration of the tablet and a resulting slow release of the active ingredients.
  • the object of the present invention is achieved in that in a hydrophilic polymer film, which rapidly decomposes after application in the oral cavity, at least two active ingredients are included, which belong to the group of anti-dementia drugs.
  • An active substance is preferably an acetylcholine nesterase inhibitor (AchE inhibitor) and the second is an NMDA antagonist (n-methyl-D-aspartic acid antagonist).
  • the improved therapeutic success of a drug combination in the treatment of dementias is due to the fact that different drugs act through different mechanisms, thereby complementing or potentiating the positive effects on memory performance.
  • the dose of the individual active ingredients can thus possibly be lowered or the effect improved.
  • the orally administered dosage form as a wafer from a rapidly disintegrating hydrophilic polymer the intake of the drugs is ensured by the patient, as it disintegrates immediately in the mouth, so that the administration and monitoring of the intake are simplified for the nursing staff.
  • the dosage form according to the invention there is already a combination of active substances adapted to the therapy, so that the administration of the medicaments in non-independent patients must be monitored only once.
  • the absorption of the active ingredients through the oral mucosa offers over other peroral forms of administration further the advantages that even patients with dysphagia patients who refuse to take tablets, or Patients who have lost swallowing due to their dementia can receive medication orally.
  • the active ingredients are not subject to the first-pass effect. Since in this way no active ingredient is metabolized before reaching the site of action, the initial dosage can be kept as low as possible. Furthermore, variations in the active substance concentration due to incomplete or delayed absorption and delayed action as a function of the amount of food ingested are suppressed or minimized. The adjustment of the patient to the required treatment dose can thus be made more reliable and the need, for example, an intake on an empty stomach can be omitted.
  • active ingredients with different mechanisms of action may be present in a combination of active ingredients which have a synergistic effect, so that smaller amounts of the active ingredients can be dosed as a result of the different physiological action and treatment of various symptoms of dementia than would be the case with single-component formulations.
  • a positive enhancing effect of this type is known for drug combinations of memantine with an AchE inhibitor.
  • the wafers may contain up to five, preferably up to three, and more preferably two active ingredients, at least one of which is an AchE inhibitor, an NMDA antagonist or a nootropic agent.
  • the dosages can be adapted to the respective needs and forms of treatment. If the mental state of the patient changes, it can easily be adjusted to a dosage form with a modified combination of active substances, generally with a higher active ingredient concentration.
  • the wafer is made of a laminate, then during production e.g. only the layer thickness of an active substance-containing layer or the concentration of the active substance are changed.
  • drugs with different active ingredient content but the same active ingredient ratio can be easily prepared via different area blanks of the dosage form. Due to their flat shape, the wafers containing the active compound combinations according to the invention are easy to carry, for example in the wallet, and are immediately available on the way, easy to take and rapidly effective, which facilitates regular use in still mobile patients.
  • Suitable anti-dementia agents for use in a combination wafer include the AchE inhibitors, NMDA antagonists and nootropics.
  • the drug combination consists of at least two drugs selected from the group comprising the AchE inhibitors, NMDA antagonists and the nootropics.
  • Suitable AchE inhibitors are rivastigmine, galanthamine, and donezepil as well as pharmaceutically acceptable salts of these active substances.
  • Memantine can be used as an NMDA antagonist.
  • the group of the nootropic agents used according to the invention includes piracetam and naftidrofuryl.
  • the preparation may contain further active ingredients which are among the vasodilators, calcium antagonists and generally circulation-promoting agents.
  • the total active ingredient content of the wafer is between 5% to 50%, preferably between 10% to 30%, and more preferably between 15% to 25%, based on the total weight of the wafer.
  • the ratio of the active substances with one another is freely variable and depends on the potency of the active substance and the desired effect or the required dosage.
  • water-soluble or swellable polymers are suitable which form a hydrophilic, water-soluble and / or swellable polymer film.
  • the polymers of the matrix of the dosage form are selected from the group consisting of dextran, polysaccharides, including starch and starch derivatives, cellulose derivatives, such as carboxymethylcellulose, ethyl or propylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, sodium carboxymethylcellulose (eg. B.
  • the polymer film may also consist of a po- lyvinyl alcohol-polyethylene glycol graft copolymer.
  • the polymer content of a dosage form according to the invention is preferably from 5 to 95% by weight, more preferably from 15 to 75% by weight, based on the dry weight of the dosage form.
  • moisturizers may be added to the film, e.g. Glycerol, propylene glycol, sorbitol, mannitol, polyethylene glycol, polyglycerol esters and the like.
  • antioxidants may be added to the wafer to stabilize the film and the active agents, e.g. Vitamin C (ascorbic acid), ascorbyl palmitate, vitamin E (tocopherol acetate), hydroxybenzoic acid derivatives.
  • active agents e.g. Vitamin C (ascorbic acid), ascorbyl palmitate, vitamin E (tocopherol acetate), hydroxybenzoic acid derivatives.
  • acidic and basic ion exchangers can also be used as stabilizers.
  • flavourings and flavorings can mask the often poor taste or smell of the active ingredients and / or give the dosage form a pleasant taste, so that the willingness to take the medication by the patient is significantly improved.
  • the active ingredient (s) of the Preparation may also be bound to an acidic or basic ion exchanger for taste masking.
  • buffering systems serves, on the one hand, to stabilize the film and the active ingredients against external influences and during storage and, on the other hand, to adjust the pH of the dosage form to a physiologically acceptable pH, so that mucous membrane irritations are avoided .
  • a buffer system can also improve the solubility of acidic or basic drugs in the matrix.
  • the administration forms according to the invention are thin, for example in the form of a wafer.
  • the thickness of the dosage form is preferably 0.1 to 5 mm, more preferably 0.5 to 1 mm.
  • the lower limit for the thickness of the dosage forms is about 50 ⁇ m.
  • the area of the dosage form is between 0.09 cm 2 and 12 cm 2 , preferably between 1 cm 2 and 8 cm 2 , and particularly preferably between 3 cm 2 and 6 cm 2 .
  • the wafers of the present invention include a disintegrant or wicking agent, e.g. a bicarbonate-acid mixture or an aerosil, which is activated by contact with liquid and accelerates the disintegration of the wafer after application and thus also the release of active ingredient.
  • a disintegrant or wicking agent e.g. a bicarbonate-acid mixture or an aerosil
  • the wafer is present as a foam, so that the release of active ingredient is even faster due to the increased surface area.
  • the active ingredients or auxiliaries it is also possible for one or more of the active ingredients or auxiliaries to be present in liquid form in the cavities of the foam.
  • permeation enhancers e.g. Substances from the groups of fatty alcohols, fatty acids, polyoxyethylene fatty alcohol ethers, polyoxyethylene fatty acid esters, fatty alcohol esters and fatty acid esters, in particular sorbitan monolaurate or esters of long-chain fatty acids with methyl, ethyl or isopropyl alcohol, or esters of fatty alcohols with acetic acid or lactic acid, or also substances such as DMSO ( Dimethylsulfoxide) and oleic diethanolamine.
  • the proportion of these substances, if present, is 0.1% by weight to 25% by weight, preferably from 1% by weight to 10% by weight, in each case based on the total weight of the active substance matrix.
  • composition of the wafer may contain compounds that retard drug release (e.g., microencapsulation).
  • the wafer has mucoadhesive properties, so that it adheres to the mucous membrane until complete dissolution.
  • This embodiment additionally facilitates the monitoring of the administration of the medicaments since the wafer adhering to the mucous membrane can not be spit out.
  • At least one of the active ingredients is bound to an ion exchanger, see above that the hydrophilic polymer disintegrates rapidly in the oral cavity, but the release of the active ingredient only delayed or at a changed pH, for example in the gastrointestinal tract, takes place.
  • active ingredients having different or higher active and absorption mechanisms can be administered in one dosage form, ie at least one of the released active substances is absorbed at the site of application, eg. B. on the oral mucosa, and the other is transported and resorbed at another location.
  • the wafer can also be constructed as a laminate with different layers, wherein the active ingredients are contained in discrete layers, which are spatially separated from each other and differ in their construction.
  • the active ingredients can be released at different sites of action or else delayed, if the disintegration time of the different layers of the wafer differs.
  • the active ingredients may be arranged in layers which disintegrate at different rates so that the entire preparation has a sustained-release effect.
  • only one of the outer layers may be mucoadhesive to promote adherence of the dosage form to the mucosa and to facilitate drug absorption through the mucosa through direct contact.
  • Dosage form is preferably in the range of 1 s to 5 minutes, more preferably in the range of 5 seconds to 1 minute, and most preferably in the range of 10 seconds to 30 seconds.
  • the dosage forms according to the invention are advantageously suitable for the administration of medicaments in the oral cavity or for rectal, vaginal or intranasal administration.
  • the present invention is further directed to the use of one of the active ingredient combination according to the invention for the preparation of an oral dosage form for the treatment of dementia diseases, wherein the dosage form is preferably formulated as a wafer.
  • the present invention is directed to a method for the therapeutic treatment of a person suffering from dementia, wherein the administration of a previously described active ingredient combination of anti-dementia agents by means of an orally administered dosage form with at least partial transmucosal absorption of at least one active ingredient.
  • the present invention is also directed to a process for the preparation of a sheet-like dosage form which comprises the following steps:

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une composition d'agents pharmaceutiques plane, se décomposant rapidement au contact de l'humidité, à base de polymères hydrophiles, pour le traitement des maladies démentielles, la forme galénique contenant une combinaison d'agents actifs d'au moins deux agents actifs, qui sont appropriés pour le traitement des démences (médicaments antidémence). De préférence, les médicaments antidémence sont choisis parmi le groupe constitué d'inhibiteurs d'anticholinestérase (inhibiteurs AChE) et d'antagonistes de NMDA (antagonistes d'acide N-méthyl-D-aspartique). L'invention concerne de plus l'utilisation d'une telle combinaison d'agents actifs pour la préparation d'un agent pharmaceutique administrable oralement pour le traitement des maladies démentielles telles que la maladie d'Alzheimer, ainsi qu'un procédé pour le traitement symptomatique de la maladie d'Alzheimer par administration orale d'une telle composition d'agents pharmaceutiques.
EP07725819A 2006-06-16 2007-06-04 Comprimé plat combiné ache-nmda Withdrawn EP2029100A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006027791A DE102006027791A1 (de) 2006-06-16 2006-06-16 AchE-NMDA-Kombinationswafer
PCT/EP2007/004951 WO2007144083A2 (fr) 2006-06-16 2007-06-04 Comprimé plat combiné ache-nmda

Publications (1)

Publication Number Publication Date
EP2029100A2 true EP2029100A2 (fr) 2009-03-04

Family

ID=38686681

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07725819A Withdrawn EP2029100A2 (fr) 2006-06-16 2007-06-04 Comprimé plat combiné ache-nmda

Country Status (8)

Country Link
US (1) US20090202597A1 (fr)
EP (1) EP2029100A2 (fr)
JP (1) JP2009539895A (fr)
CN (1) CN101460144A (fr)
BR (1) BRPI0711503A2 (fr)
CA (1) CA2653030A1 (fr)
DE (1) DE102006027791A1 (fr)
WO (1) WO2007144083A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101985040A (zh) * 2010-11-08 2011-03-16 北京阜康仁生物制药科技有限公司 一种新的药用组合物
CN103596551B (zh) * 2011-06-08 2017-02-22 Lts勒曼治疗系统股份公司 含有用于掩味的离子交换树脂的食用口服条或糯米纸囊剂型
US9687445B2 (en) 2012-04-12 2017-06-27 Lts Lohmann Therapie-Systeme Ag Oral film containing opiate enteric-release beads
CN105806818B (zh) * 2016-04-01 2019-11-22 南京医科大学 检测血小板nmda受体活性的方法及其应用
DE102017127434A1 (de) * 2017-11-21 2019-05-23 Lts Lohmann Therapie-Systeme Ag Taschenförmige oral auflösende Filme mit hoher Wirkstoffbeladung
CN108926549A (zh) * 2018-09-27 2018-12-04 安徽安科余良卿药业有限公司 卡巴拉汀凝胶贴膏及其制备方法
CN109498643A (zh) * 2018-12-06 2019-03-22 北京斯利安药业有限公司 一种叶酸组合物及其在制备改善老年失智药物中的应用
CN111234323A (zh) * 2020-03-27 2020-06-05 南京林业大学 一种高强度阻燃性半乳甘露聚糖基复合膜的制备方法
DE102021100780A1 (de) 2021-01-15 2022-07-21 Lts Lohmann Therapie-Systeme Ag. Oraler dünnfilm mit pva-tris-pufferschicht

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE82916B1 (en) * 1990-11-02 2003-06-11 Elan Corp Plc Formulations and their use in the treatment of neurological diseases
DE19960154A1 (de) * 1999-12-14 2001-07-12 Lohmann Therapie Syst Lts Flache Arzneizubereitung zur transmucosalen Verabreichung von Oxycodon oder einem vergleichbaren Wirkstoff in der Mundhöhle, für die Anwendung in der Schmerztherapie und Suchttherapie
DE10032456A1 (de) * 2000-07-04 2002-01-31 Lohmann Therapie Syst Lts Schnell zerfallende Darreichungsform zur Freisetzung von Wirkstoffen im Mundraum oder in Körperhöhlen
US20060014773A1 (en) * 2001-04-19 2006-01-19 Mccleary Edward L Mental agility lozenge, edible strip, food or drink
DE10207394B4 (de) * 2002-02-21 2007-03-29 Lts Lohmann Therapie-Systeme Ag Geschmacksmaskierte oblatenförmige Arzneizubereitung
DE10226494A1 (de) * 2002-06-14 2004-01-08 Lts Lohmann Therapie-Systeme Ag Filmförmige mucoadhäsive Darreichungsformen zur Verabreichung von Cannabis-Wirkstoffen
DE10338544B4 (de) * 2003-08-19 2017-08-31 Janssen Pharmaceutica N.V. Buccale Formulierungen des Galanthamins und deren Anwendungen
DE10354894A1 (de) * 2003-11-24 2005-07-07 Hf Arzneimittelforschung Gmbh Orale Formulierungen des Desoxypeganins und deren Anwendungen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2007144083A2 *

Also Published As

Publication number Publication date
CA2653030A1 (fr) 2007-12-21
WO2007144083A3 (fr) 2008-04-17
DE102006027791A1 (de) 2007-12-20
US20090202597A1 (en) 2009-08-13
WO2007144083A2 (fr) 2007-12-21
JP2009539895A (ja) 2009-11-19
CN101460144A (zh) 2009-06-17
BRPI0711503A2 (pt) 2011-11-01

Similar Documents

Publication Publication Date Title
WO2007144083A2 (fr) Comprimé plat combiné ache-nmda
EP1067905B1 (fr) Formulations de spray
EP1067904B1 (fr) Formulations solides et a decomposition rapide contenant de la cetirizine
DE102006027794A1 (de) Antihypertonie-Kombinationswafer
EP2029101A2 (fr) Comprimé plat combiné pour le diabète de type 2
WO2007144080A2 (fr) Comprimé plat combinée d'antidépresseurs
WO2007144085A1 (fr) Cachet comprenant une association d'opioïde
WO2009036906A1 (fr) Composition avec combinaison de principes actifs constituée d'un laxatif et d'un agent antimoussant, pour le traitement de la constipation
CH662734A5 (de) Antischnarchmittel.
EP2029098A2 (fr) Comprimé plat combiné pour le sevrage tabagique
DE102010024866A1 (de) Formulierung zur Geschmacksmaskierung
DE102006027796A1 (de) Estrogen-Gestagen-Kombinationen
DE10338544B4 (de) Buccale Formulierungen des Galanthamins und deren Anwendungen
DE10354894A1 (de) Orale Formulierungen des Desoxypeganins und deren Anwendungen
DE102020112143B4 (de) Nicotin - Corona
EP3299010B1 (fr) Forme pharmaceutique orale
EP3618812A1 (fr) Comprimé orodispersible, contenant un anti-histaminique h1
WO2019166098A1 (fr) Forme pharmaceutique orale contenant du cacao sans théobromine
DE202016005032U1 (de) Schnell zerfallende Efeu-Trinktabletten ohne Zerfallsbeschleuniger
DE10301930A1 (de) Verfahren zur medikamentösen therapeutischen oder prophylaktischen Behandlung

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20081121

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK RS

17Q First examination report despatched

Effective date: 20090323

DAX Request for extension of the european patent (deleted)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Effective date: 20091205