EP2010215A4 - Utilisations et compositions pour le traitement de la maladie de crohn - Google Patents

Utilisations et compositions pour le traitement de la maladie de crohn

Info

Publication number
EP2010215A4
EP2010215A4 EP07755288A EP07755288A EP2010215A4 EP 2010215 A4 EP2010215 A4 EP 2010215A4 EP 07755288 A EP07755288 A EP 07755288A EP 07755288 A EP07755288 A EP 07755288A EP 2010215 A4 EP2010215 A4 EP 2010215A4
Authority
EP
European Patent Office
Prior art keywords
crohn
disease
compositions
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07755288A
Other languages
German (de)
English (en)
Other versions
EP2010215A2 (fr
Inventor
Paul F Pollack
Rebecca S Hoffman
Cheryl Renz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Biotechnology Ltd
Original Assignee
Abbott Biotech Ltd Bermuda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Biotech Ltd Bermuda filed Critical Abbott Biotech Ltd Bermuda
Priority to EP13173241.4A priority Critical patent/EP2666480A3/fr
Publication of EP2010215A2 publication Critical patent/EP2010215A2/fr
Publication of EP2010215A4 publication Critical patent/EP2010215A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
EP07755288A 2006-04-10 2007-04-10 Utilisations et compositions pour le traitement de la maladie de crohn Withdrawn EP2010215A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP13173241.4A EP2666480A3 (fr) 2006-04-10 2007-04-10 Utilisations et compositions pour le traitement de la maladie de Crohn

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US79090906P 2006-04-10 2006-04-10
US80261606P 2006-05-22 2006-05-22
US80285806P 2006-05-22 2006-05-22
US80977006P 2006-05-30 2006-05-30
US81548906P 2006-06-20 2006-06-20
US84996706P 2006-10-06 2006-10-06
US90463707P 2007-03-01 2007-03-01
US90462607P 2007-03-01 2007-03-01
US91817407P 2007-03-14 2007-03-14
PCT/US2007/008962 WO2007120720A2 (fr) 2006-04-10 2007-04-10 Utilisations et compositions pour le traitement de la maladie de crohn

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP13173241.4A Division EP2666480A3 (fr) 2006-04-10 2007-04-10 Utilisations et compositions pour le traitement de la maladie de Crohn

Publications (2)

Publication Number Publication Date
EP2010215A2 EP2010215A2 (fr) 2009-01-07
EP2010215A4 true EP2010215A4 (fr) 2010-06-16

Family

ID=38610153

Family Applications (2)

Application Number Title Priority Date Filing Date
EP13173241.4A Withdrawn EP2666480A3 (fr) 2006-04-10 2007-04-10 Utilisations et compositions pour le traitement de la maladie de Crohn
EP07755288A Withdrawn EP2010215A4 (fr) 2006-04-10 2007-04-10 Utilisations et compositions pour le traitement de la maladie de crohn

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP13173241.4A Withdrawn EP2666480A3 (fr) 2006-04-10 2007-04-10 Utilisations et compositions pour le traitement de la maladie de Crohn

Country Status (3)

Country Link
EP (2) EP2666480A3 (fr)
CA (1) CA2564435A1 (fr)
WO (1) WO2007120720A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110138412A (ko) 2009-04-16 2011-12-27 애보트 바이오테라퓨틱스 코포레이션 항-ΤΝＦ-α 항체 및 그의 용도
EP3659598A1 (fr) * 2012-06-04 2020-06-03 Gaurav Agrawal Compositions et procédés de traitement de la maladie de crohn et des pathologies et infections associées
US10946091B2 (en) 2012-06-04 2021-03-16 Gaurav Agrawal Compositions and methods for treating Crohn's disease and related conditions and infections
US10376582B2 (en) 2013-10-16 2019-08-13 Outlook Therapeutics, Inc. Buffer formulations for enhanced antibody stability
EP3247718B1 (fr) 2015-01-21 2021-09-01 Outlook Therapeutics, Inc. Modulation de variants de charge dans une composition d'anticorps monoclonaux
EP3078675A1 (fr) * 2015-04-10 2016-10-12 Ares Trading S.A. Régime de dosage à induction pour le traitement des maladies liées au tnf alpha
CA3013336A1 (fr) 2016-02-03 2017-08-10 Oncobiologics, Inc. Formulations de tampon pour ameliorer la stabilite d'anticorps

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US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0154316B1 (fr) 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Lymphokine chimiquement modifiée et son procédé de préparation
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (fr) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Récepteurs chimériques par liaison et expression de l'ADN
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
ATE135370T1 (de) 1988-12-22 1996-03-15 Kirin Amgen Inc Chemisch modifizierte granulocytenkolonie erregender faktor
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5959087A (en) 1989-08-07 1999-09-28 Peptide Technology, Ltd. Tumour necrosis factor binding ligands
US6451983B2 (en) 1989-08-07 2002-09-17 Peptech Limited Tumor necrosis factor antibodies
WO1991003553A1 (fr) 1989-09-05 1991-03-21 Immunex Corporation RECEPTEURS DES FACTEURS NECROSE TUMORALE α et $g(b)
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
CA2109602C (fr) 1990-07-10 2002-10-01 Gregory P. Winter Methodes de production de membres de paires de liaison specifiques
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
EP0564531B1 (fr) 1990-12-03 1998-03-25 Genentech, Inc. Methode d'enrichissement pour des variantes de l'hormone de croissance avec des proprietes de liaison modifiees
JP4146512B2 (ja) 1991-03-01 2008-09-10 ダイアックス コープ． 小型タンパク質
US5656272A (en) 1991-03-18 1997-08-12 New York University Medical Center Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
DK1471142T3 (da) 1991-04-10 2009-03-09 Scripps Research Inst Heterodimere receptor-biblioteker under anvendelse af fagemider
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
EP0605522B1 (fr) 1991-09-23 1999-06-23 Medical Research Council Méthodes de production d'anticorps humanisés
EP0636026B1 (fr) 1992-04-02 2001-12-05 Smithkline Beecham Corporation Composes utilisables dans le traitement des maladies inflammatoires et dans l'inhibition de la production du facteur de necrose tumorale
AU670125B2 (en) 1992-09-15 1996-07-04 Immunex Corporation Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
HU230048B1 (hu) 1996-02-09 2015-06-29 Abbvie Biotechnology Ltd Humán TNFalfa-kötő antitestek alkalmazása
UA81743C2 (uk) 2000-08-07 2008-02-11 Центокор, Инк. МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
WO2002072636A2 (fr) 2000-12-28 2002-09-19 Altus Biologics Inc. Cristaux d'anticorps entiers et fragments d'anticorps et methodes de fabrication et d'utilisation associees
CA2817619A1 (fr) 2001-06-08 2002-12-08 Abbott Laboratories (Bermuda) Ltd. Methodes pour administrer des anticorps anti-tnf.alpha.
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
TWI556829B (zh) * 2004-04-09 2016-11-11 艾伯維生物技術有限責任公司 用於治療ＴＮＦα相關失調症之多重可變劑量療法
IT1395574B1 (it) 2009-09-14 2012-10-16 Guala Dispensing Spa Dispositivo di erogazione

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Title
D'HAENS GEERT ET AL: "Advances in medical therapy for Crohn's disease.", CURRENT GASTROENTEROLOGY REPORTS DEC 2004 LNKD- PUBMED:15527680, vol. 6, no. 6, December 2004 (2004-12-01), pages 496 - 505, XP002580099, ISSN: 1522-8037 *
HANAUER ET AL: "A randomized, double-blind, placebo-controlled trial of the human anti-TNF-alpha monoclonal antibody adalimumab for the induction of remission in patients with moderate to severely active Crohn's disease", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA LNKD- DOI:10.1053/J.GASTRO.2004.05.010, vol. 127, no. 1, 1 July 2004 (2004-07-01), pages 332, XP002580094, ISSN: 0016-5085 *
HANAUER ET AL: "Human Anti-Tumor Necrosis Factor Monoclonal Antibody (Adalimumab) in Crohn's Disease: the CLASSIC-I Trial", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA LNKD- DOI:10.1053/J.GASTRO.2005.11.030, vol. 130, no. 2, 1 February 2006 (2006-02-01), pages 323 - 333, XP005284535, ISSN: 0016-5085 *
HANAUER S B ET AL: "Rapid response to human anti-TNF monoclonal antibody adalimumab in patients with moderate to severely active Crohn's disease in the CLASSIC study", AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 100, no. 9, Suppl. S, 850, September 2005 (2005-09-01), & 70TH ANNUAL MEETING OF THE AMERICAN-COLLEGE-OF-GASTROENTEROLOGY; HONOLULU, HI, USA; OCTOBER 30 -NOVEMBER 02, 2005, pages S313 - S314, XP002580097, ISSN: 0002-9270 *
PANACCIONE ET AL: "Advances in medical therapy of inflammatory bowel disease", CURRENT OPINION IN PHARMACOLOGY, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 5, no. 6, 1 December 2005 (2005-12-01), pages 566 - 572, XP005134765, ISSN: 1471-4892 *
PAPADAKIS KONSTANTINOS A ET AL: "Safety and efficacy of adalimumab (D2E7) in Crohn's disease patients with an attenuated response to infliximab", AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 100, no. 1, January 2005 (2005-01-01), pages 75 - 79, XP002580098, ISSN: 0002-9270 *
SANDBORN WILLIAM ET AL: "Adalimumab, a human anti-TNF-alpha monoclonal antibody, induces clinical remission and response in patients with moderate to severely active Crohn's Disease irrespective of smoking status", AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 99, no. 10, Suppl. S, 800, October 2004 (2004-10-01), & 69TH ANNUAL MEETING OF THE AMERICAN-COLLEGE-OF-GASTROENTEROLOGY; ORLANDO, FL, USA; OCTOBER 29 -NOVEMBER 03, 2004, pages S259 - S260, XP002580096, ISSN: 0002-9270 *
SANDBORN WILLIAM ET AL: "Induction and maintenance of clinical remission and response in subjects with Crohn's disease treated during a 6-month open-label period with fully human anti-TNF-a monoclonal antibody adalimumab (humira((R)))", GASTROENTEROLOGY, vol. 128, no. 4, Suppl. 2, 723, April 2005 (2005-04-01), & ANNUAL MEETING OF THE AMERICAN-GASTROENTEROLOGICAL-ASSOCIATION/DIGEST IVE-DISEASE-WEEK; CHICAGO, IL, USA; MAY 14 -19, 2005, pages A111 - A112, XP002580095, ISSN: 0016-5085 *
SANDBORN WILLIAM J ET AL: "An open-label study of the human anti-TNF monoclonal antibody adalimumab in subjects with prior loss of response or intolerance to infliximab for Crohn's disease", AMERICAN JOURNAL OF GASTROENTEROLOGY, ELSEVIER SCIENCE INC, US LNKD- DOI:10.1111/J.1572-0241.2004.40462.X, vol. 99, no. 10, 1 October 2004 (2004-10-01), pages 1984 - 1989, XP002477488, ISSN: 0002-9270 *
SANDBORN WILLIAM J ET AL: "Maintenance of remission over 1 year in patients with active Crohn's disease treated with adalimumab: Results of a blinded, placebo-controlled study", AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 100, no. 9, Suppl. S, 843, September 2005 (2005-09-01), & 70TH ANNUAL MEETING OF THE AMERICAN-COLLEGE-OF-GASTROENTEROLOGY; HONOLULU, HI, USA; OCTOBER 30 -NOVEMBER 02, 2005, pages S311, XP002580092, ISSN: 0002-9270 *
SANDBORN WILLIAM J ET AL: "Remission and clinical response induced and maintained in patients with active Crohn's disease treated for 1-year open-label with adalimumab", AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 100, no. 9, Suppl. S, 858, September 2005 (2005-09-01), & 70TH ANNUAL MEETING OF THE AMERICAN-COLLEGE-OF-GASTROENTEROLOGY; HONOLULU, HI, USA; OCTOBER 30 -NOVEMBER 02, 2005, pages S316 - S317, XP002580093, ISSN: 0002-9270 *

Also Published As

Publication number Publication date
WO2007120720A3 (fr) 2007-12-21
WO2007120720A2 (fr) 2007-10-25
EP2666480A3 (fr) 2014-07-30
EP2666480A2 (fr) 2013-11-27
EP2010215A2 (fr) 2009-01-07
CA2564435A1 (fr) 2007-10-10

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