EP2005992A1 - Miniaturröntgenquellenvorrichtung zum Durchführen einer Strahlentherapie sowie Verfahren zum Durchführen einer Strahlentherapiebehandlung an einem anatomischen Bereich eines Tierkörpers mittels der Miniaturröntgenquellenvorrichtung - Google Patents

Miniaturröntgenquellenvorrichtung zum Durchführen einer Strahlentherapie sowie Verfahren zum Durchführen einer Strahlentherapiebehandlung an einem anatomischen Bereich eines Tierkörpers mittels der Miniaturröntgenquellenvorrichtung Download PDF

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Publication number
EP2005992A1
EP2005992A1 EP07011953A EP07011953A EP2005992A1 EP 2005992 A1 EP2005992 A1 EP 2005992A1 EP 07011953 A EP07011953 A EP 07011953A EP 07011953 A EP07011953 A EP 07011953A EP 2005992 A1 EP2005992 A1 EP 2005992A1
Authority
EP
European Patent Office
Prior art keywords
source device
miniature
ray source
anode
cathode
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07011953A
Other languages
English (en)
French (fr)
Inventor
Johann Kindlein
Evert Hendrik Agterhuis
Godefridus Hendricus Maria Gubbels
Frank Simonis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nucletron Operations BV
Original Assignee
Nucletron Operations BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nucletron Operations BV filed Critical Nucletron Operations BV
Priority to EP07011953A priority Critical patent/EP2005992A1/de
Priority to PCT/EP2008/004860 priority patent/WO2008155092A1/en
Priority to US12/665,491 priority patent/US8559598B2/en
Publication of EP2005992A1 publication Critical patent/EP2005992A1/de
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J35/00—X-ray tubes
    • H01J35/02—Details
    • H01J35/14—Arrangements for concentrating, focusing, or directing the cathode ray
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J35/00—X-ray tubes
    • H01J35/02—Details
    • H01J35/16—Vessels; Containers; Shields associated therewith
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J2235/00—X-ray tubes
    • H01J2235/06—Cathode assembly
    • H01J2235/062—Cold cathodes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J2235/00—X-ray tubes
    • H01J2235/08—Targets (anodes) and X-ray converters
    • H01J2235/081—Target material
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J2235/00—X-ray tubes
    • H01J2235/16—Vessels
    • H01J2235/163—Vessels shaped for a particular application
    • H01J2235/164—Small cross-section, e.g. for entering in a body cavity
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J2235/00—X-ray tubes
    • H01J2235/16—Vessels
    • H01J2235/165—Shielding arrangements
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J2235/00—X-ray tubes
    • H01J2235/20—Arrangements for controlling gases within the X-ray tube
    • H01J2235/205—Gettering
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J35/00—X-ray tubes
    • H01J35/02—Details
    • H01J35/04—Electrodes ; Mutual position thereof; Constructional adaptations therefor
    • H01J35/08—Anodes; Anti cathodes
    • H01J35/112—Non-rotating anodes
    • H01J35/116—Transmissive anodes

Definitions

  • the invention also relates to a method for performing radiation therapy treatment on an anatomical portion of an animal body using a miniature X-ray source device.
  • Radiation therapy is a well-established method for treatment of several diseases, including cancer.
  • the presumptive usefulness of a miniature X-ray source device is clear.
  • the insertion of such a source device into vessels or other body cavities would allow the delivered radiation dose to be confide to a small tissue region.
  • a catheter with a miniaturized X-ray source device could be used for irradiation of cardiovascular tissue.
  • a miniature X-ray source device comprises a vacuum tube, wherein a cathode and an anode spaced apart are accommodated.
  • the anode is mounted on a distal end of the miniature X-ray source device.
  • the vacuum tube is to be evacuated to a preferred vacuum level required for a proper operation of the miniature X-ray source device.
  • the known miniature X-ray source device is provided with electric field means for establishing a high-voltage electric field between the anode and cathode. Electrons emitted from the cathode are accelerated by the established high-voltage electric field and impact with a high kinetic energy on the anode material. In the anode material X-ray radiation is generated with a high energy level.
  • the generated radiation can leave the vacuum tube towards the patient's tissue in which the X-ray source device is inserted.
  • the generated X-ray radiation leaving the miniature X-ray source device exhibits a high energy level, the X-ray radiation is highly suitable for performing radiation therapy in the patient's body, for example for treating cancer tumours.
  • X-ray radiation is also the main type of radiation used for the treatment of skin cancers.
  • Low energy X-rays (lees than 90 kV) do not penetrate very deep into the body tissue. Those rays transmit most of their energy into the skin and are therefore used for the treatment of skin cancers.
  • the dose of radiation to be delivered is fractionated. For most skin cancers a total of 10-25 fractions are administered, wherein the radiation therapy is administered by specially trained radiation therapist and each fraction usually takes 15-20 minutes. The subsequent fractions are usually given on daily basis (Monday-Friday) and a full treatment course can take 2-5 weeks to complete.
  • the cathode exhibits a concave shaped surface having a center part surrounded by an upright circumferential edge, wherein the center part of the concave shaped surface is provided with an electron emitting material.
  • the center part of the concave shaped surface has a flat configuration.
  • the cathode is of a cold cathode type formed from carbon nanotubes.
  • the cathode is a so-called cathode type formed from carbon nanotubes
  • carbon nanotubes are aligned mono-wall nanotubes or carbon nanotubes are aligned multi-wall nanotubes.
  • the carbon nanotubes may be randomised nanotubes.
  • a getter material is located in a high-voltage electric field free region in the vacuum tube.
  • An essentially electric field free location of the getter material is required as therefore the getter would not present any internal electrical problems associated with surface arcing or breakdown.
  • the use of a getter material inside the vacuum tube improves the vacuum level inside.
  • the second material is for example tungsten.
  • the layer of the second material has a thickness between [xx] and [yy] ⁇ m and preferably approximately 20 ⁇ m.
  • An additional control of the bundle characteristics of the X-ray radiation being emitted from the anode can be achieved as according to a further embodiment within the vacuum tube a diaphragm lense element is disposed between the cathode and the anode for bundling the electrons being emitted towards the anode.
  • the diaphragm lense element is electrically controllable.
  • a grid shaped electron absorbing element is disposed between the cathode and the diaphragm lense element for absorbing any electrons being reflected from the diaphragm lense element towards the cathode.
  • a further enhanced control of the bundle characteristics of the X-ray radiation being emitted from the anode is possible as according to a beneficial further embodiment the anode is displacable accommodated within the X-ray source device with respect to the exit window.
  • the vacuum tube is at least partly made from an electrically isolating material and more in particular it is preferred that the electrically isolating material is coated with a polymer layer. This gradually reduces the voltage difference existing between the cathode and the anode (which is normally kept at ground potential), thereby enhancing the performance of the X-ray source device.
  • the X-ray source device has a cilindrical shape with a diameter of 1-2.5 mm and a length of 2-3 cm.
  • the X-ray source device comprises cooling means for cooling at least the anode.
  • the source device is mounted using a movable robotic arm of a therapy treatment system, the movement of the robotic arm being controlled by information generated by imaging means and therapy treatment planning means of the therapy treatment system.
  • the imaging means may comprise a laserscanning device.
  • FIG. 1 a known miniature X-ray source device according to the state of the art is disclosed showing the miniature X-ray source device 10 in a longitudinal cross-section.
  • the miniature X-ray source device 10 according to the prior art comprises a housing 11 with an exit window 11a for the X-ray radiation being generated.
  • a vacuum tube or chamber 12 is accommodated containing an cathode 13 and an anode 14 spaced apart from each other within space 20 of the vacuum tube 11.
  • the cathode material 14 consist of an electron emitting material from which electrons are freed using techniques already known in the art.
  • a known miniature X-ray source device is further provided with means 16 for establishing a high-voltage electric field between the anode 14 and cathode 13.
  • the cathode 13 is connected with an supply wire connected with a high-voltage source, whereas the anode 14 is kept at ground potential.
  • the radiation dose distribution thus generated is not always applicable for certain radiation therapy treatments, for example brachytherapy.
  • the embodiment of the miniature X-ray source device of Figure 2 is provided with an anode 14 which is provided with a flat X-ray emitting surface.
  • the flat X-ray emitting surface 14a of the anode 14 allows a proper handling of the miniature X-ray source device 10 especially for the treatment of skin cancer.
  • the X-ray source device 10 has to be placed with the exit window 11 a on the skin of the patient to be treated in order to direct the X-ray radiation generated within the flat anode 14 towards the skin and the intended side to be treated.
  • the electron emitting material 13c of the cathode 13 is preferably of a cold cathode type formed from carbon nanotubes, which are preferably aligned mono-wall nanotubes. Another embodiment the carbon nanotubes are aligned multi-wall nanotubes. In both embodiments it is also possible to use randomized nanotubes.
  • the getter material 30 is electrically isolated accommodated within the vacuum tube 12 (space 20) and serves to eliminate or capture stray gas molecules still present within the cavity 20 of the vacuum tube 12. Therefore the use of a getter material 30 guarantees a low vacuum level within the vacuum tube 12 necessary for a proper operation of the miniature X-ray source device according to the invention.
  • a grid shaped electron absorbing element 26 (see Figures 3a-3b ) is disposed between the cathode 13 and the anode 14 for absorbing any electrons being reflected. By absorbing these reflected free electrons the cathode 13 is being protected from inpinching electrons thereon. Moreover with the use of a grid 26 the flexibility of the X-ray source device 10 is increased. The use of a grid element 26 makes it possible to change the electron current between the cathode and the anode through the vacuum tube 12 at a constant acceleration voltage being applied by the electron freeing means 16. This allows the X-ray radiation dose being emitted to be changed and altered effectively.
  • the vacuum tube 12 is made from an electrically isolating material covered with a polymer layer.
  • the polymer coating layer can be for example be of the material green Pyrotek TS-207, which coating source to gradually reduce the voltage difference between the cathode 13 and the anode 14.
  • the exit window 11a (not depicted) which covers the flat shaped anode 14 can be made from Al 2 O 3 /W or Be/W. Also in this embodiment the anode 14 is kept at ground potential.
  • the opening 25a of the diaphragm lens element 25 has a circular shape other configurations are possible depending on the desired bundle characteristic of the electron current inpinching on the anode 14.
  • the opening 25 can be for example square or polygonal.
  • the embodiment of Figures 3a and 3b disclose a further feature used to modify the bundle characteristics of the X-ray radiation 21 being emitted by the anode 14.
  • the vacuum tube and more in particular the anode 14 is displacable accommodated within the housing 11 of the miniature X-ray source 10.
  • the displacement means 27 can be for example a spindle drive motor which advances and retracts a spindle 27 being connected with the vacuum tube 12.
  • other displacement means are considered possible and known in the art for example a transmission of gears wherein the thief mess with eachother.
  • the vacuum tube 12 is displaced in such manner that the anode 14 is positioned at a relative short distance of the exit window 11a.
  • radiation shielding walls 30a-30b are accommodated within the housing 11 which radiation shielding walls surface as collimating elements modifying the outer dimensions of the X-ray radiation bundle 21 being emitted by the anode 14.
  • an assembly 100 of multiple miniature X-ray source devices is disclosed.
  • the assembly 100 is composed of multiple miniature X-ray source devices 10-10'-10"-etc.-etc. which miniature X-ray source device upon activation emit several, individual bundles 21 of X-ray radiation.
  • the assembly 100 allows radiation treatment sessions to be performed when large skin surface area are to be iradiated.
  • a radiation therapy treatment apparatus 200 comprising a treatment planning unit 250 as well as a high voltage source 220, a coolant generating means 230 and drive means 240 for driving or manipulating a robot arm 210 provided with a connector 212, to which a miniature X-ray source device 10 according to the invention can be mounted.
  • the robotic arm 210 is build up of several segments 211 interconnected by means of hinging elements 213. Through the robotic arm 210 an electric signal conductor is guided for connecting the miniature X-ray source device 10 and especially the electron freeing means 16 (not depicted but shown in Figures 2-4a-4b ) with the high voltage source 220.
  • a coolant guide tube (not shown) is mounted through the robotic arm 210 towards the cooling means 28a-28c (see other figures) for cooling down the anode 14.
  • the displacement of the robotic arm 10 using the robotic drive means 240 allows a proper and accurate displacement of the miniature X-ray source device 10 across the skin C of a patient A above an intended treatment side B (for example a cancerous tumour to be treated with X-ray radiation).
  • the method for performing radiation therapy treatment on an anatomical portion B of an animal body A can be performed using a miniature X-ray source device according to the invention.
  • the method first comprises the step of obtaining one or more three-dimensional images of the skin surface near said anatomical portion using imaging means 260, which can be a laser scanning device. Said said three-dimensional image of said target volume can be displayed to an user using displaying means (not shown).
  • the exact location of said anatomical portion is determined.
  • This can be a tumour located at some distance/depth under the skin surface or it can be a cancerous area of skin cancer.
  • the three-dimensional images of the skin surface can be obtained by placing/using one or more marker elements on the skin surface.
  • the treatment planning means 250 contain processing means, which can be a computer on which a treatment planning software module is running. Said treatment plan may include information concerning the overall amount of radiation dose to be emitted to the anatomical portion, and one or more target locations within the anatomical portion to be treated. Also for each target location the partial dose distribution as well as the dwell time (the duration of the radiation for that target location) is determined.
  • the treatment plan as generated by the treatment planning means 250 contain information about the position in which the miniature X-ray source device has to be position relative to each target location. This position information also contains planning information concerning the distance of the miniature X-ray source device relative to the skin surface for each position.
  • this distance information (more in particular the skin-anode distance) is important for an accurate and correct administation of the X-ray radiation from the anode towards the target location within the anatomical portion to be treated.
  • the operational parameters of the miniature X-ray source device for each target location are contained in the treatment plan. These operational parameters contain information about the high voltage / current potentials to be applied to the minitature X-ray source device as well as the collimating setting value of the electrically controllable diaphragm lense element.
  • the pre-planned position and distance information parameters are used to control the movable robotic arm 210 via the in order to properly displace the miniature X-ray source device 10 to the corresponding actual postions and distances relative to the skin surface and anatomical portion to be treated.
  • the miniature X-ray source device 10 is positioned at an actual position / distance according the pre-planned parameters the actual radiation of the corresponding target location within the anatomical portion B is started.
  • the actual position of the miniature X-ray source device 10 is being determined using the imaging means 260 and compared with the pre-planned postion parameters.
  • the course of treatment will be adapted by controlling the robotic arm 210 (repositioning the X-ray source device) and by adapting the operational parameters of the X-ray source device.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)
EP07011953A 2007-06-19 2007-06-19 Miniaturröntgenquellenvorrichtung zum Durchführen einer Strahlentherapie sowie Verfahren zum Durchführen einer Strahlentherapiebehandlung an einem anatomischen Bereich eines Tierkörpers mittels der Miniaturröntgenquellenvorrichtung Withdrawn EP2005992A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP07011953A EP2005992A1 (de) 2007-06-19 2007-06-19 Miniaturröntgenquellenvorrichtung zum Durchführen einer Strahlentherapie sowie Verfahren zum Durchführen einer Strahlentherapiebehandlung an einem anatomischen Bereich eines Tierkörpers mittels der Miniaturröntgenquellenvorrichtung
PCT/EP2008/004860 WO2008155092A1 (en) 2007-06-19 2008-06-17 Miniature x-ray source device for effecting radiation therapy
US12/665,491 US8559598B2 (en) 2007-06-19 2008-06-17 Miniature X-ray source device for effecting radiation therapy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07011953A EP2005992A1 (de) 2007-06-19 2007-06-19 Miniaturröntgenquellenvorrichtung zum Durchführen einer Strahlentherapie sowie Verfahren zum Durchführen einer Strahlentherapiebehandlung an einem anatomischen Bereich eines Tierkörpers mittels der Miniaturröntgenquellenvorrichtung

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Publication Number Publication Date
EP2005992A1 true EP2005992A1 (de) 2008-12-24

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EP07011953A Withdrawn EP2005992A1 (de) 2007-06-19 2007-06-19 Miniaturröntgenquellenvorrichtung zum Durchführen einer Strahlentherapie sowie Verfahren zum Durchführen einer Strahlentherapiebehandlung an einem anatomischen Bereich eines Tierkörpers mittels der Miniaturröntgenquellenvorrichtung

Country Status (3)

Country Link
US (1) US8559598B2 (de)
EP (1) EP2005992A1 (de)
WO (1) WO2008155092A1 (de)

Cited By (2)

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NL2005904C2 (en) * 2010-12-22 2012-06-25 Nucletron Bv A mobile x-ray unit.
NL2005903C2 (en) * 2010-12-22 2012-06-25 Nucletron Bv A mobile x-ray unit.

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JP5641916B2 (ja) * 2010-02-23 2014-12-17 キヤノン株式会社 放射線発生装置および放射線撮像システム
EP2649634B1 (de) * 2010-12-10 2018-07-04 Canon Kabushiki Kaisha Strahlungserzeugungsgerät und strahlungsbildgebungsgerät
NL2005900C2 (en) * 2010-12-22 2012-06-25 Nucletron Bv A mobile x-ray unit.
NL2005901C2 (en) * 2010-12-22 2012-06-25 Nucletron Bv A mobile x-ray unit.
WO2013106794A2 (en) * 2012-01-12 2013-07-18 Sensus Healthcare, Llc Hybrid ultrasound-guided superficial radiotherapy system and method
ITVR20120035A1 (it) * 2012-03-05 2012-06-04 Roberto Molteni Sorgenti radiografiche compatte per carico moderato utilizzanti tubo radiogeno con catodo a nanotubi di carbonio.
WO2014036225A1 (en) * 2012-08-29 2014-03-06 Source Production & Equipment Co., Inc. Radiation therapy of protruding and/or conformable organs
US9984847B2 (en) * 2013-03-15 2018-05-29 Mars Tohken Solution Co., Ltd. Open-type X-ray tube comprising field emission type electron gun and X-ray inspection apparatus using the same
CN103337443B (zh) * 2013-04-27 2016-05-18 中国人民解放军北京军区总医院 医学检测用x射线源及移动ct扫描仪
TWI552187B (zh) * 2014-11-20 2016-10-01 能資國際股份有限公司 冷陰極ｘ射線產生器的封裝結構及其抽真空的方法
US10068741B2 (en) 2014-12-25 2018-09-04 Meidensha Corporation Field emission device and reforming treatment method
CN109789315A (zh) 2016-07-13 2019-05-21 胜赛斯医疗有限责任公司 机器人术中放疗
WO2018183873A1 (en) 2017-03-31 2018-10-04 Sensus Healthcare Llc Three-dimensional beam forming x-ray source
CN111148547A (zh) 2017-07-18 2020-05-12 胜赛斯医疗有限责任公司 术中放射治疗中的实时x射线剂量测定
EP3544680A4 (de) * 2017-08-29 2020-06-24 Sensus Healthcare, Inc. Robotisches iort-röntgenstrahlungssystem mit kalibrierungsbett
US20190189384A1 (en) * 2017-12-18 2019-06-20 Varex Imaging Corporation Bipolar grid for controlling an electron beam in an x-ray tube
US11672491B2 (en) 2018-03-30 2023-06-13 Empyrean Medical Systems, Inc. Validation of therapeutic radiation treatment
US10940334B2 (en) 2018-10-19 2021-03-09 Sensus Healthcare, Inc. Systems and methods for real time beam sculpting intra-operative-radiation-therapy treatment planning

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US20060060793A1 (en) * 2004-09-21 2006-03-23 The University Of Chicago Laparoscopic tumor therapy using high energy electron irradiation

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Cited By (6)

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Publication number Priority date Publication date Assignee Title
NL2005904C2 (en) * 2010-12-22 2012-06-25 Nucletron Bv A mobile x-ray unit.
NL2005903C2 (en) * 2010-12-22 2012-06-25 Nucletron Bv A mobile x-ray unit.
WO2012087133A1 (en) * 2010-12-22 2012-06-28 Nucletron Operations B.V. A mobile x-ray unit
WO2012087126A1 (en) * 2010-12-22 2012-06-28 Nucletron Operations B.V. A mobile x-ray unit
US8520801B2 (en) 2010-12-22 2013-08-27 Nucletron B.V. Mobile X-ray unit
US9168391B2 (en) 2010-12-22 2015-10-27 Nucletron B.V. Mobile X-ray unit

Also Published As

Publication number Publication date
WO2008155092A1 (en) 2008-12-24
US20100246766A1 (en) 2010-09-30
US8559598B2 (en) 2013-10-15

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