EP1989000A2 - Verfahren zur herstellung eines kapillaren netzes für einen chip - Google Patents

Verfahren zur herstellung eines kapillaren netzes für einen chip

Info

Publication number
EP1989000A2
EP1989000A2 EP07731045A EP07731045A EP1989000A2 EP 1989000 A2 EP1989000 A2 EP 1989000A2 EP 07731045 A EP07731045 A EP 07731045A EP 07731045 A EP07731045 A EP 07731045A EP 1989000 A2 EP1989000 A2 EP 1989000A2
Authority
EP
European Patent Office
Prior art keywords
capillaries
layer
plate
side walls
chip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07731045A
Other languages
English (en)
French (fr)
Inventor
Nicolas Ugolin
Pascal Wodling
Julien Le Meur
Pierre-Yves Tro
Sylvie Chevillard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Publication of EP1989000A2 publication Critical patent/EP1989000A2/de
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure

Definitions

  • Each of these areas may correspond to all or part of a layer of building material.
  • the laser beam can be focused and moved to areas of this layer bordering only the location of future capillaries, or on areas of the layer located between the locations of the future capillaries, and between these locations and the edges of the support plate.
  • the molecules attached to the support plate are independent of the molecules attached to the closure plate but can interact with them.
  • molecules can be attached to the support plate at one end, the other end of which can be fix on or at least interact with the closure plate, once it is attached to the side walls of the capillaries.
  • this method consists in removably fixing the closure plate on the side walls of the capillaries to allow the opening and closing at will of the capillary network.
  • the closure plate can be detached manually or by a suitable tool from the capillary network and be fixed again on the walls Lateral capillaries by melting another film of fusible material deposited on the walls of the capillaries or film of previously used material, provided that it can be melted several times without degrading.
  • the film of material has a low melting temperature, ie a melting temperature sufficiently low so as not to degrade by thermal conduction the side walls of the capillaries.
  • the melting temperature of an EVA copolymer film is about 176 ° C.
  • the method may further comprise, prior to step a), the steps of fixing chemical or biological molecules on the support plate, at the level of the funds of the future capillaries, then covering these molecules with a layer of a soluble protective material.
  • the molecules when the molecules are fixed on the plate of before the formation of the walls of the capillaries, they must be protected to prevent their degradation, in particular during the deposition and melting steps of the construction material on the support plate.
  • the method according to the invention may further comprise a step of removing by laser ablation or any other suitable technique the surplus of protective material which does not cover chemical or biological molecules.
  • Chemical or biological molecules can be attached in at least one of the capillaries, on the support plate and / or on the closure plate.
  • the capillaries extend substantially parallel to one another and are connected at each of their ends to a reservoir. These reservoirs may for example be connected to means for injecting and discharging a molecular target mixture into the capillary network.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
EP07731045A 2006-02-27 2007-02-26 Verfahren zur herstellung eines kapillaren netzes für einen chip Withdrawn EP1989000A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0601704A FR2897858B1 (fr) 2006-02-27 2006-02-27 Procede de fabrication d'un reseau de capillaires d'une puce
PCT/FR2007/000341 WO2007096535A2 (fr) 2006-02-27 2007-02-26 Procede de fabrication d'un reseau de capillaires d'une puce

Publications (1)

Publication Number Publication Date
EP1989000A2 true EP1989000A2 (de) 2008-11-12

Family

ID=36999320

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07731045A Withdrawn EP1989000A2 (de) 2006-02-27 2007-02-26 Verfahren zur herstellung eines kapillaren netzes für einen chip

Country Status (6)

Country Link
US (1) US20090054264A1 (de)
EP (1) EP1989000A2 (de)
JP (1) JP2009528513A (de)
CN (1) CN101389408A (de)
FR (1) FR2897858B1 (de)
WO (1) WO2007096535A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5022208B2 (ja) * 2007-12-19 2012-09-12 積水化学工業株式会社 ヘモグロビン類の測定システム
US8545771B2 (en) 2009-08-12 2013-10-01 Caliper Life Sciences, Inc. Fluidic devices having incorporated electrodes
WO2011106255A1 (en) * 2010-02-23 2011-09-01 Caliper Life Sciences, Inc. Fluidic devices having incorporated electrodes
CN102008927B (zh) * 2010-09-25 2011-11-16 北京航空航天大学 一种多层次非晶合金基微结构的制备方法
JP5616309B2 (ja) 2010-12-01 2014-10-29 アークレイ株式会社 デバイス及びその製造方法
TW201317567A (zh) * 2011-10-24 2013-05-01 Univ Nat Central 偵測昇華點之系統及方法
WO2013109334A1 (en) * 2011-11-07 2013-07-25 Caliper Life Sciences, Inc. Fluidic devices having incorporated electrodes
WO2013148312A1 (en) * 2012-03-26 2013-10-03 Alere San Diego, Inc. Microfluidic pump
US20140172051A1 (en) * 2012-12-14 2014-06-19 Satinderpall S. Pannu Single layer polymer microelectrode array
EP2811299A1 (de) * 2013-06-07 2014-12-10 Roche Diagniostics GmbH Testelement zur Detektion von mindestens einem Analyten in einer Körperflüssigkeit
JP6764222B2 (ja) * 2015-07-28 2020-09-30 株式会社朝日Ｆｒ研究所 マイクロ化学チップ及びその製造方法
WO2017062807A1 (en) * 2015-10-07 2017-04-13 Arizona Board Of Regents On Behalf Of Arizona State University Live-cell seeding method for microarrays
NL2019044B1 (en) 2017-05-11 2018-11-15 Illumina Inc Protective surface coatings for flow cells
GB201913529D0 (en) * 2019-09-19 2019-11-06 Tanriverdi Ugur Method And Apparatus
CN113200512B (zh) * 2021-02-26 2024-03-19 西湖大学 一种小间隙金属纳米腔结构、制备方法及设备
US20220299426A1 (en) * 2021-03-22 2022-09-22 Tellspec, Ltd. Hinged cuvette with electromagnetic blocking

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Publication number Priority date Publication date Assignee Title
US5174943A (en) * 1984-08-08 1992-12-29 3D Systems, Inc. Method for production of three-dimensional objects by stereolithography
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US20020053399A1 (en) * 1996-07-30 2002-05-09 Aclara Biosciences, Inc Methods for fabricating enclosed microchannel structures
GB9623185D0 (en) * 1996-11-09 1997-01-08 Epigem Limited Improved micro relief element and preparation thereof
US6495195B2 (en) * 1997-02-14 2002-12-17 Arcturus Engineering, Inc. Broadband absorbing film for laser capture microdissection
US6375871B1 (en) * 1998-06-18 2002-04-23 3M Innovative Properties Company Methods of manufacturing microfluidic articles
US6131410A (en) * 1998-03-16 2000-10-17 The Regents Of The University Of California Vacuum fusion bonding of glass plates
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
WO2001017797A1 (en) * 1999-09-10 2001-03-15 Caliper Technologies Corp. Microfabrication methods and devices
US6814926B2 (en) * 2003-03-19 2004-11-09 3D Systems Inc. Metal powder composition for laser sintering
JP2007505747A (ja) * 2003-09-17 2007-03-15 ナノコムス・パテンツ・リミテッド マイクロ構造デバイス及びその製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2007096535A2 *

Also Published As

Publication number Publication date
FR2897858A1 (fr) 2007-08-31
JP2009528513A (ja) 2009-08-06
WO2007096535A3 (fr) 2007-10-11
CN101389408A (zh) 2009-03-18
FR2897858B1 (fr) 2008-06-20
US20090054264A1 (en) 2009-02-26
WO2007096535A2 (fr) 2007-08-30

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CHEVILLARD, SYLVIE

Inventor name: TRO, PIERRE-YVES

Inventor name: LE MEUR, JULIEN

Inventor name: WODLING, PASCAL

Inventor name: UGOLIN, NICOLAS

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES

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