EP1981574A1 - Adaptateur pour inhalateurs destinés au traitement de patients ventilés artificiellement - Google Patents

Adaptateur pour inhalateurs destinés au traitement de patients ventilés artificiellement

Info

Publication number
EP1981574A1
EP1981574A1 EP07704308A EP07704308A EP1981574A1 EP 1981574 A1 EP1981574 A1 EP 1981574A1 EP 07704308 A EP07704308 A EP 07704308A EP 07704308 A EP07704308 A EP 07704308A EP 1981574 A1 EP1981574 A1 EP 1981574A1
Authority
EP
European Patent Office
Prior art keywords
drug
amino
quinazoline
phenyl
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07704308A
Other languages
German (de)
English (en)
Inventor
Michael Pieper
Heribert Hurtig
Matthaeus Mueller
Hans Schmitt
Juergen Schraivogel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Publication of EP1981574A1 publication Critical patent/EP1981574A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
    • A61M16/0816—Joints or connectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • the invention relates to an apparatus for delivering respiratory gases in conjunction with a powder inhaler for the inhalative administration of drugs, drug mixtures or drug formulations to patients connected to ventilators.
  • a powder inhaler for the inhalative administration of drugs, drug mixtures or drug formulations to patients connected to ventilators.
  • Preferred is the administration of drugs, drug mixtures or drug formulations to patients who are artificially ventilated under anesthesia via a mask or a tracheal tube.
  • Respirators supply the patient to be ventilated with respiratory gas, e.g. via supplying hose lines.
  • respiratory gas e.g. via supplying hose lines.
  • Respirators supply medicines to ventilated patients by inhalation route.
  • This is the case, for example, in patients with lung diseases, for example in inflammatory or obstructive lung diseases such as asthma or COPD.
  • topical treatment in the lungs is often beneficial to achieve a sufficiently high topical drug concentration in the lung and to reduce systemic side effects of the drugs.
  • a nebulizer may introduce an aerosol into the breathing gas-carrying tubing by means of a tee which is inserted into the ventilator's feeding tubing.
  • These nebulisers generate an aerosol by energy, for example by ultrasound or air pressure or compressed propellant gas. At the same time an air flow is generated, which transports the aerosol away from the nebulizer.
  • WO04 / 098689 discloses a nebulizer connection device for ventilators, which enables a simplified connection and removal of a nebulizer, without an interruption or impairment of the respiratory air supply occurring during connection and removal of the nebulizer.
  • the nebulizer connection device is hereby constructed for the ventilator by special
  • Breathing air guiding devices, connecting devices and closing devices are provided.
  • the basis of the inhalative administration of powdered pharmaceutical formulations in capsules is the generation of an aerosol by active inspiration of the patient, without further addition of propellant gas.
  • the pressure difference generated by the inspiration of the patient leads to a flow of air into the lungs.
  • this air stream is passed through a mouthpiece of a powder capsule inhaler, the perforated drug capsules are vibrated in the inhaler. This process leads to the depletion of the capsule, the generation of the aerosol and the transport of the drug into the respiratory tract.
  • the present invention relates to a device for supplying respiratory gases in connection with a powder inhaler for the inhalative administration of drugs, drug mixtures or drug formulations to patients who
  • Ventilators are connected. Preferred is the administration of drugs, drug mixtures or drug formulations to patients who are artificially ventilated under anesthesia via a mask or a tracheal tube.
  • Drugs, drug mixtures, or pharmaceutical formulations are preferably in powder form, which are formulated in capsules for aerosol generation and used in powder inhalers.
  • Eg HandiHaler ®, ® Xcelovair, Aerolizer ® or GyroHaler ® Very particularly preferred pharmaceutical composition, pharmaceutical compounds or drug formulations in powder form which are formulated in capsules for aerosol generation and used in the HandiHaler ®.
  • the inhaler is connected directly to the adapter for the respiratory system at a corresponding connection. Another possibility is Without the inhaler, insert the powder capsule directly into a corresponding chamber in the respiratory air supply hose of the ventilation system.
  • the ventilation air that is actively supplied under pressure from the ventilation system causes the capsule to vibrate, resulting in the release of the drug and the generation of an aerosol.
  • This aerosol is delivered directly to the respiratory tract without active inspiration from the patient.
  • the aerosol generated by the powder inhaler is therefore absorbed by the respiratory gas flow directly at the place of generation and supplied to the patient's airways.
  • the generation of the aerosol and the intake by the breathing air-supplying gas flow is advantageously in an axis with the tube which supplies the respiratory gas-aerosol mixture to the patient.
  • the aerosol is thus supplied to the patient with little impaction in the breathing air-supplying tube system.
  • An advantageous supply of the patient with active ingredients in aerosol form can thus be achieved.
  • a continuous inhaled medication or medication or drug administration already carried out with the inhaler can also be continued after the patient has been connected to a respiratory system.
  • the air flow of the respiratory system can either be constantly passed through the nebulizer connected to the adapter or it can be fed directly to the patient by a manually or automatically actuated valve bypassing the powder inhaler.
  • the powder inhaler is a commercially available device from the market, which is sold under the trade name HandiHaler ®. It is also described in EP 0 703 800 B1 or EP 0 911 047 A1.
  • the inhaler known from the documents mentioned above has a cup-shaped lower part and a matching, also shell-like lid. Lower part and lid can be unfolded for use via a joint arranged in the edge area. Between the lower part and the lid engage in the joint nor a likewise fold-away mouthpiece and an underlying plate with arranged underneath capsule holder.
  • the patient can put a drug-filled capsule in the capsule holder, swing the plate with capsule holder and the mouthpiece back into the lower part and attach the capsule via a laterally protruding from the lower part, spring-biased actuator. By sucking on the mouthpiece then the drug enters the respiratory tract of the patient to be treated.
  • substance formulations As pharmaceutically active substances, substance formulations or
  • Substance mixtures are used for all inhalable compounds, e.g. also inhalable macromolecules, as disclosed in EP 1 003 478.
  • substances, substance formulations or substance mixtures are used for the treatment of respiratory diseases, which are used in the inhalation area.
  • drugs selected from the group consisting of anticholinergics, betamimetics, steroids, phosphodiesterase IV inhibitors, LTD4 antagonists and EGFR kinase inhibitors, antiallergics, derivatives of ergot alkaloids, triptans, CGRP antagonists, phosphodiesterase - V inhibitors, and combinations of such agents, eg
  • Betamimetics plus anticholinergics or betamimetics plus antiallergics In the case of combinations, at least one of the active ingredients has chemically bound water. Preference is given to using anticholinergic agents, as monoproparates or in the form of combination preparations.
  • Applicable anticholinergics are preferably selected from the group consisting of tiotropium bromide, oxitropium bromide, flutropium bromide, ipratropium bromide, glycopyrronium salts, trospium chloride, tolterodine, 2,2-
  • Applicable betamimetics are preferably selected from the group consisting of albuterol, bambuterol, bitolterol, broxaterol, carbuterol, clenbuterol, fenoterol, formoterol, hexoprenaline, ibuterol, indacaterol, isoetharines, isoprenaline, levosalbutamol, mabuterol, meluadrine, metaproterenol, orciprenaline, pirbuterol, Procaterol, Reproterol, Rimiterol, Ritodrine, Salmeterol, Salmefamol, Soterenot, Sulphone terol, Tiaramide, Terbutaline, Tolubuterol, CHF-1035, HOKU-81, KUL-1248, 3- (4- ⁇ 6- [2-hydroxy-2- (4-hydroxy-3-hydroxymethyl-phenyl) -ethyl-amino] - hexyloxy ⁇ -but
  • Applicable steroids are preferably selected from the group consisting of prednisolone, prednisone, butixocortepionate, RPR-106541, flunisolide, beclomethasone, triamcinolone, budesonide, fluticasone, mometasone, ciclesonide, rofleponide, ST-126, dexamethasone, 6 ⁇ , 9 ⁇ -difluoro- 17 ⁇ - [(2-furanylcarbonyl) oxy] -1 ⁇ -hydroxy-16 ⁇ -methyl-3-oxo-androsta-1,4-diene-17 ⁇ -carbothionic acid (S) -fluoromethyl ester, 6 ⁇ , 9 ⁇ -difluoro-11 ⁇ - hydroxy-16 ⁇ -methyl-3-oxo-17 ⁇ -propionyloxy-androsta-1,4-diene
  • Applicable PDE IV inhibitors are preferably selected from the group consisting of enprofylline, theophylline, roflumilast, ariflo (cilomilast), CP- 325,366, BY343, D-4396 (Sch-351591), AWD-12-281 (GW-842470), N- (3,5-dichloro-1-oxo-pyridin-4-yl) -4-difluoromethoxy-3- cyclopropylmethoxybenzamide, NCS-613, pumafentine, (-) p - [(4 ⁇ R *, 10 ⁇ S *) - 9-ethoxy-1,2,3,4,4a, 10b-hexahydro-8-methoxy-2-methylbenzo [s] [1, 6] naphthyridin-6-yl] -N, N-diisopropylbenzamide, (R) - (+) - 1 - (4-bromobenzyl) -4 -
  • Applicable LTD4 antagonists are preferably selected from the group consisting of montelukastol, l - (((R) - (3- (2- (6,7-difluoro-2-quinolinyl) ethenyl) phenyl) -3 - ( 2- (2-hydroxy-2-propyl) phenyl) thio) methylcyclopropaneacetic acid, 1- ((1 (R) -3- (3- (2- (2,3-Dichlorothieno [3,2-b] pyridine -5-yl) - (E) -ethenyl) phenyl) - 3- (2- (1-hydroxy-1-methylethyl) phenyl) propyl) thio) methyl) cyclopropaneacetic acid, pranlukast, zafirlukast, [2 - [[2- (4-tert-butyl-2-thiazolyl) -5-benzofuranyl] oxymethyl
  • Applicable EGFR kinase inhibitors are preferably selected from the group consisting of cetuximab, trastuzumab, ABX-EGF, Mab ICR-62, 4 - [(3-chloro-4-fluorophenyl) amino] -6- [4- (morpholin-4-yl) -1-oxo-2-buten-1-yl] amino ⁇ -7-cyclopropylmethoxy-quinazoline, 4 - [(R) - (1-phenylethyl) ammo] -6 - ⁇ [ 4- (morpholin-4-yl) -1-oxo-2-butene-1-yl] amino ⁇ -V-cyclopentyloxy-quinazoline, 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- ⁇ [4 - ((R) -6-methyl-2-oxomorpholin-4-yl) -1-oxo-2-
  • salts are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrobenzoate, hydrocitrate, hydrofumarate, Hydrotartrate, hydrooxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate, preferably hydrochloride, hydrobromide, hydrosulfate, hydrophosphate, hydrofumarate and hydromethanesulfonate understood.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un dispositif d'alimentation en gaz respiratoires en liaison avec un inhalateur de poudre servant à administrer par inhalation des substances médicamenteuses, des mélanges médicamenteux ou des formulations médicamenteuses à des patients qui sont reliés à des appareils respiratoires. Un mode de réalisation préféré est l'administration de substances médicamenteuses, de mélanges médicamenteux ou de formulations médicamenteuses à des patients sous anesthésie qui sont ventilés artificiellement par l'intermédiaire d'un masque ou d'une sonde trachéale.
EP07704308A 2006-02-01 2007-02-01 Adaptateur pour inhalateurs destinés au traitement de patients ventilés artificiellement Withdrawn EP1981574A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006004528A DE102006004528A1 (de) 2006-02-01 2006-02-01 Adapter für Inhalationsgeräte zur Behandlung von künstlich beatmeten Patienten
PCT/EP2007/050987 WO2007088188A1 (fr) 2006-02-01 2007-02-01 Adaptateur pour inhalateurs destinés au traitement de patients ventilés artificiellement

Publications (1)

Publication Number Publication Date
EP1981574A1 true EP1981574A1 (fr) 2008-10-22

Family

ID=37888287

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07704308A Withdrawn EP1981574A1 (fr) 2006-02-01 2007-02-01 Adaptateur pour inhalateurs destinés au traitement de patients ventilés artificiellement

Country Status (6)

Country Link
US (1) US20090025722A1 (fr)
EP (1) EP1981574A1 (fr)
JP (1) JP2009525096A (fr)
CA (1) CA2637533A1 (fr)
DE (1) DE102006004528A1 (fr)
WO (1) WO2007088188A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
EP2534957B1 (fr) 2007-12-14 2015-05-27 AeroDesigns, Inc Administration de produits sous forme d'aérosols
DK2265309T3 (en) 2008-03-17 2016-03-29 Discovery Lab Inc FAN EXCEEDED RACE ADAPTER AND proximal AEROSOLFORSYNINGSSYSTEM
CA2683353C (fr) 2008-10-22 2015-12-15 Trudell Medical International Systeme modulaire d'administration d'aerosol
US20130319410A1 (en) * 2012-05-30 2013-12-05 The University Of Kansas Inhalation device, systems, and methods for administering powdered medicaments to mechanically ventilated subjects
CA3059172C (fr) 2013-03-15 2023-01-24 Trudell Medical International Circuit de ventilateur, adaptateur pour circuit de ventilateur et leurs procedes d'utilisation
CN112969490B (zh) * 2018-10-30 2024-07-12 奇斯药制品公司 用于向机械辅助呼吸患者施用药物的设备

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
EP0590289A1 (fr) * 1992-09-28 1994-04-06 Engström Medical Ab Abouchement d'un patient
US5642730A (en) * 1994-06-17 1997-07-01 Trudell Medical Limited Catheter system for delivery of aerosolized medicine for use with pressurized propellant canister
US6014972A (en) * 1997-12-11 2000-01-18 Thayer Medical Corporation Dry drug particle delivery system and method for ventilator circuits
BRPI0416654A (pt) * 2003-11-17 2007-01-16 Nektar Therapeutics introdução de aerossol a um circuito ventilador
WO2005065756A2 (fr) * 2003-12-30 2005-07-21 Oriel Therapeutics, Inc. Nebuliseurs de poudre seche et procedes associes de dispersion de poudres seches
BRPI0616642A2 (pt) * 2005-09-29 2011-06-28 Nektar Therapeutics formulações de antibióticos, doses unitárias, kits e métodos

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2007088188A1 *

Also Published As

Publication number Publication date
DE102006004528A1 (de) 2007-08-02
WO2007088188A1 (fr) 2007-08-09
JP2009525096A (ja) 2009-07-09
CA2637533A1 (fr) 2007-08-09
US20090025722A1 (en) 2009-01-29

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