EP1978912B1 - Packaging for medical products and similar - Google Patents

Abstract

The packaging (10) has a substrate (14) equipped with one or several preassembled, closed product carriers (16), which contain multiple, individual medicinal products (11) for a defined period of time, and provided with instructions for application and/or the administration time for the patient. Each product carrier contains exclusive products of a special active substance or a special active substance combination in a special dosage. An independent claim is also included for a method for production of packaging.

Description

The invention relates to a packaging for pharmaceutical and / or medical products and / or dietary supplements, comprising a substrate equipped with one or more prefabricated, sealed product carriers, each containing one or more isolated products for a defined period of time and with instructions for use - or taking time for the patient is provided, each product carrier in each case only carries products of a specific drug or a specific drug combination in a specific dosage. Furthermore, the invention relates to a method and an apparatus for producing said packages.

For the primary packaging of pharmaceutical and / or medical products and / or dietary supplements (which are also referred to as products hereinafter), tablets, dragees, ampoules, vitamin preparations but also syringes or the like may be mentioned by way of example, different requirements are of importance. On the one hand, there are constant efforts to make it easier for the patient to take the medication or to use the products. The existing packaging support the patient in addition to the simplified removal of the product from the packaging by appropriate removal aids in the dosage and the temporal intake of the drugs. These aspects are commonly known by the terms "convenience" or "senior friendliness" (SF). On the other hand, the issue of child safety, the so-called "child resistance" (CR), is of increasing regulatory importance. The common packaging is therefore secured by various measures against unauthorized removal, especially by children.

Especially with pharmaceutical and / or medical products, however, the reliability of compliance with the prescribed pharmaceuticals is of particular importance, which should be supported by the so-called compliance packaging. It has been found that patients more reliably take the medication prescribed to them when one or more and / or different medicaments are arranged side by side or together within a package and the required application or administration times are indicated by calendars and times. For example, in addition to antibiotics, stomach protection preparations are to be taken at the same time. The arrangement or compilation of the drugs by day of the week and time of day makes it easier for the patient to take his prescribed medication reliably, which is particularly important for chronically ill patients of particular importance.

On the market packaging is known and available, which ensure a patient-specific compilation of one or more products. The products are either filled directly as raw material or after unpacking from a package in the appropriate patient-specific packaging, eg in compartments of packaging units. However, this requires, on the one hand, that the filling must be carried out under defined clean-room conditions and with pharmaceutical specialists, which leads to very high costs. On the other hand, the partial manual unpacking and repackaging is prone to error, costly and expensive due to the multitude of work steps and furthermore leads to a mechanical loading of the products. Incidentally, the packaging of medicines from raw materials and the handling of raw materials after unpacking are subject to special legal conditions, the fulfillment of which means a considerable outlay. In the known packages produced according to the methods described above, several different products / tablets may be arranged in a receiving space, such as a bag, a tubular bag, a nest of a blister pack or the like. However, this is particularly disadvantageous because of the risk of cross-contamination. To avoid such cross-contamination, there are efforts to place the products individually on a packaging in a closed state. That means the Products are arranged individually in a compartment of a packaging unit or a nest of blister packaging and packaged in such a way to put together for the patient intended packaging.

From the EP 0 852 208 A1 Furthermore, a tablet container with the features of the preamble of claim 1 is known. This packaging comprises a substrate on which several isolated products are arranged in sealed product carriers, wherein the dosage of the same active substance or the same combination of active ingredients for the treatment of Parkinson's disease gradually (1st day one tablet, 2nd day one tablet, 3rd day two Tablets, 4th day, three tablets etc.) increases. The products are prefabricated in flat blisters. Such blisters have several columns and several lines, for example as 2x5 blisters. This means that the products lie one after the other in sealed nests of the blister tray / blister magazine. Locked in this context means that each product within the nest is enclosed on all sides with respect to the environment, so that the products are protected against external influences (mechanical stress or other contaminants, in particular biological or chemical contamination). Product carriers separated from the blister tray / blister magazine may contain one or more isolated products. These product carriers are then assembled into a therapy-specific packaging. In addition to the just mentioned disadvantage of a purely therapy-specific compilation of the products, an automated production of such packaging is also possible only with undue effort, since, for example, the separation of individual product carriers from a flat and multi-line blister tray must take place in different directions. In summary, the packaging described in said EP-font is composed exclusively therapy-specific and automatically only uneconomical to produce.

It is therefore an object of the present invention to provide a secure, cost-effective and patient-specific packaging. Furthermore, it is an object of the invention to provide a corresponding method and an apparatus for producing the packaging.

The object is achieved on the one hand by a package having the features mentioned above in that each product carrier is part of a rollable and single-web blister pack and the product carriers containing one or more individual products are individually placed on the substrate, the substrate carrying a blister composite or forms, such that a plurality of at least one nest having portions of the product-specific Blistergurtverpackungen each with different isolated products of an active ingredient or a drug combination of one or more manufacturers are applied to the substrate, the product carriers lie with one side on the substrate and on the other side are at least partially covered by a separately supplied cover element. Thus, a patient-specific packaging is created in a particularly simple and cost-effective manner, since the packaging or the substrate can be assigned one or more different products in a freely selectable amount. In other words, the packaging allows for each patient freely selectable intake times of the day. A decisive advantage lies in the fact that the products are protected from the actual production up to the opening / removal by the patient, since the products lie in the closed product carriers even during and after the arrangement of the patient-individual packing and thus neither mechanical and / or other influences exposed to the environment are still a cross-contamination is to be feared. The problems with handling with raw material can therefore be circumvented with this packaging and a sterile assembly can be ensured in a simple manner. However, this also means that the most diverse products can be brought together by different manufacturers from a third party. The fact that each product carrier is part of a roll-up and single-line blister strip packaging means that the packaging can be produced automatically with simple means, which offers a considerable economic advantage, even with individual packaging (no packaging must be the same to others) and the number of packages produced. The packaging according to the invention for the first time ever created a package that combines in a particularly simple manner packaged products from several manufacturers and presented in a patient-individual way.

Advantageously, exactly one product is arranged in each nest of each blister strip packaging or each section of blister strip packaging. As a result, in addition to the avoidance of cross-contamination further abrasion of the products can be prevented with each other. Each product is optimal and maximally protected.

The packaging is fully automatic. As a result, a faultless assembly of the products is guaranteed to a packaging, so that incorrect medications are avoided. The automatic production also ensures the required cost-effectiveness of the packaging.

On the other hand, the object is achieved by a method for producing a packaging for pharmaceutical and / or medical products and / or dietary supplements by the following steps: providing a substrate, selecting patient-specific products for a defined period of time, separating pre-assembled, sealed product carriers with the selected, patient-specific Products of roll-up and single-lane Blistergurtverpackungen, each product carrier in each case carries only one or more isolated products of a specific drug or a specific drug combination in a special dosage, automatic positioning and fixing the separated product carriers on the substrate according to the patient-specific specifications, wherein by applying several Sections of the product-specific Blistergurtverpackungen a Blisterverbund is formed, the Blisterverbund from Produktträgem with Produ kten of different manufacturers is formed, in which case a separately supplied lid member is then applied to the substrate on the substrate, so that the or each product carrier is disposed between the lid member and the substrate. By this method, it is possible in a particularly simple way to produce patient-specific packaging economically, since the individual products can be separated without unpacking and repackaging in the desired amount of Blistergurtverpackung and assembled to form a Blisterverbundes. Due to the fact that the products are always protected, ie from the production to the removal by the patient in the nest of the blister strip packaging, the compilation of the products into a patient-specific packaging can also be carried out by third parties who are not manufacturers of pharmaceutical products / medicines. This increases the flexibility in the production of the final packaging. By providing the products on roll-up blister straps, which are particularly easy to machine, a particularly simple combination of different products is guaranteed by different manufacturers to a device for the production of the packaging.

By automatically producing the packaging, errors in the selection and assembly of the products can be reduced.

The object is also achieved by a device which is characterized in that it comprises a transport element for feeding and discharging individual blanks forming the substrates, receiving places for blister straps in which the products are arranged singly and closed, with a separating means for separating each receptacle the product carrier or the sections of the blister strip is assigned, as well as a placement head for transporting the product carrier or sections separated from the blister strip from a provision position to the dispensing position on the substrate, wherein the device is designed and arranged for feeding separate lid elements.

Fig. 1

eine schematische Darstellung einer Verpackung mit einer beispielhaften patientenspezifischen Zusammenstellung der Medikamente,

Fig. 2

eine Vergrößerung des Ausschnitts II in der Figur 1,

Fig. 3

eine schematische Darstellung einer weiteren Verpackung mit einer patientenspezifischen Zusammenstellung der Medikamente,

Fig. 4

eine schematische Darstellung einer weiteren Verpackung mit einer patientenspezifischen Zusammenstellung der Medikamente,

Fig. 5

eine schematische Darstellung einer weiteren Verpackung mit einer patientenspezifischen Zusammenstellung der Medikamente,

Fig. 6

eine schematische Schnittdarstellung der Verpackungen gemäß der Figuren 1 bis 5, und

Fig. 7

eine schematische Darstellung einer Vorrichtung zur Herstellung von Verpackungen gemäß der Figuren 1 bis 5.

Further advantageous features and further developments of the packaging and the device as well as further preferred method steps emerge from the subclaims and the description. The packaging, the device and the manufacturing method will be explained with reference to the accompanying drawings. In the drawing shows:

Fig. 1

a schematic representation of a package with an exemplary patient-specific compilation of the drugs,

Fig. 2

a magnification of the section II in the FIG. 1 .

Fig. 3

a schematic representation of another packaging with a patient-specific compilation of drugs,

Fig. 4

a schematic representation of another packaging with a patient-specific compilation of drugs,

Fig. 5

a schematic representation of another packaging with a patient-specific compilation of drugs,

Fig. 6

a schematic sectional view of the packaging according to the FIGS. 1 to 5 , and

Fig. 7

a schematic representation of an apparatus for the production of packaging according to the FIGS. 1 to 5 ,

The packaging described below is used for patient-specific and individual care of patients with pharmaceutical and / or medical products and / or nutritional supplements. In particular, the packages are used to hold tablets, dragees or the like.

Each of the packaging 10 shown is provided or equipped with products 11 for a defined period of time, whereby the individual therapy can last for a very long time, in particular for chronically ill patients. In this case, the time period as in the embodiments shown may be e.g. be defined as weekly calendar 12. However, monthly or quarter graduations may also be provided on the packages 10. In addition to the period, the packaging 10 has instructions or information 13 about the actual application or administration times.

The package 10 comprises a substrate 14, which may be made of cardboard, plastic or other suitable materials. The substrate 14 may be flat, ie fan-free or, as in the exemplary embodiments, designed as a folding element 15, for example, to form a so-called wallet packaging. The above-mentioned weekly calendar 12 and the information 13 are on the existing preferably as a blank Substrate 14 applied for example by printing, embossing or the like. The substrate 14 may each have a perforation or other material weakening in columns and rows in order to simplify a section-wise separation of individual rows and / or columns.

On the substrate 14 prescription and / or pharmacy and / or freely available products 11 are arranged. These products 11 are protected on or within Produktträgem 16. The product carrier 16 are part of a prefabricated (not explicitly shown) packaging type, in particular a blister (gurt) packaging. The prefabricated product carriers 16 are subdivided into sections 17 by separating them from the blister pack, each section 17 having exclusively products 11 of one type or, more precisely, of a specific active substance or a specific combination of active substances with a defined dose. In other words, each product type is associated with its own product carrier 16. The product carriers 16 and / or sections 17 have so-called nests 18 in a manner customary for blister packs, each of which is designed to receive a single product 11. In other words, each nest 18 is assigned only a single product 11. Preferably, each product 11 of the product carrier 16 is individually identified uniquely with a corresponding optical code. The nests 18 are covered by a film 26 or the like, so that they are completely shielded from the environment. The individual product carriers 16 or the corresponding sections 17 form a blister composite 19 with the substrate 14. Such a blister composite 19 can accordingly have a plurality of sections 17 which are separated from a blister strip, the sections 17 being identical or different (from different blister straps). Products 11 may contain from one or more manufacturers. The sections 17 are arranged in the form of a matrix with columns and rows according to the administration, wherein a first section 17 one or more separately housed each in a nest 18 copies example of a drug A and a second section 17 one or more separately from each other in a nest 18 encased specimens example of a drug B has. The number of rows and the number of columns correspond to an x-times intake on one day and a y-days extending income period.

Depending on the need, requirement or recipe, the products 11 are individually selected and applied with their respective product carriers 16 on the substrate 14. In this case, the product carriers 16 or the sections 17 are firmly connected to the substrate 14, for example by heat bonding or the like. Other common attachment means, e.g. by clamping or similar However, they are also possible. The substrate 14 itself can serve as a package 10. However, the substrate 14 can also be arranged on or in an outer packaging. Preferably, the substrate 14 or individual parts of the substrate carrying the product carriers 16 with the products 11 are detachably arranged on the outer packaging, so that they can optionally be fed to a preferably electronic dispensing device. In other words, the package 10 can be combined with measures of the SF and CR described above.

The substrate 14 may have perforated or pre-punched areas through which the products 11 can be pressed out of the product carriers 16. Again FIG. 6 can be seen, these areas may also be formed as an opening 20. The product carriers 16 or the sections 17 rest on the substrate 14 on one side (top or bottom side). According to the invention, the product carriers 16 on the other side are at least partially covered by a cover element 21; ie, the product carriers 16 are sandwiched between the cover element 21 and the substrate 14. In this case, the cover element 21 can also prove openings 22 through which the nests 18 protrude with the products 11 (see in particular FIG FIG. 6 ). It should be understood, however, that the package 10 may be formed solely from a substrate 14 having the product carriers 16 disposed thereon or underneath, which embodiment does not fall within the scope of the claims. The product carriers 16 can be covered at least partially from one side with cardboard or the like, ie, for example, the substrate 14, or from both sides with cardboard or the like, that is, for example, the substrate 14 and the cover element 21. With such a cover element 21, the product carriers 16 or sections 17 can additionally be fixed and positioned relative to the substrate 14 as well as with each other.

The package 10 are associated with further information 23, this information 23 attached as a package insert and / or in printed form on the Substrate 14 or other surfaces of the package 10 are arranged. For example, information about the individual medicines, the manufacturers or other relevant messages can be removably inserted into a slot or adhered to the package 10 as a leaflet or booklet. Information on patient data, by way of example, a patient photo may be mentioned here, date of manufacture of the products 11, treating physician, responsible pharmacy, health insurance, producing bottler, distributor, and other necessary for an unmistakable assignment and / or tracing, etc., as well as logos and brands of manufacturers and other information may be printed on the package 10. The information 12, 13, 23 may be glued, printed and / or embossed (eg in Braille) or applied in another known manner, the positioning of the information 12, 13, 23 preferably laterally on the substrates 14, the product carriers 16 etc. can be arranged. In addition, for example, for accounting reasons, a consecutive number or the like may be formed on the packaging 10. Also, the package may be attached to 10 media, audio media or other media.

Some of the information, in particular as to the contents of the package 10, may be used for purposes of simple inspection / comparison or e.g. with the recipe data also in coded form e.g. be arranged as a bar code 24 or the like on the package 10. In principle, all information 12, 13, 23 can be embodied in legibly written form and / or as coding, for example with a luminophore marking. In addition, the packaging 10 may have an electronic component 25, in particular a memory chip. By means of this device 25 is also a communication to external systems for purposes of control, testing or the like possible.

The above-described packaging 10 may be made manually or automatically. A variety of packaging types can be formed, for example a packaging 10 with one and the same product of a manufacturer or a packaging 10 with different products and / or the same products with different dosages of an active ingredient of a manufacturer or a packaging 10 with products from different manufacturers. Any other combinations are also possible. Selected examples are explained below.

The FIGS. 1 to 5 In each case, a package 10 is to be taken, which includes a "Wochenration" for a particular patient. These are in accordance with the packaging FIG. 1 , which, for example, represents a possible therapy regimen for a long-term therapy of a chronic illness, stores six different products (A to F) from different manufacturers in different dosages per day. The number of products to be taken 11 varies. In addition to information about the manufacturer, the packaging 10 also carries product instructions (see in particular FIG. 2 ). In the package 10 according to FIG. 3 are all products 11, which correspond to the drug and the dosage, from a manufacturer. In addition to the manufacturer's instructions, information on the medicament itself (name, active substance, dosage, etc.) may alternatively also be indicated on the packaging 10. From the package 10 according to the FIG. 3 It can be seen that in addition to sections 17 with one or two nests 18 in a field of the matrix, continuous section strips (eg from Monday to Thursday in the 8 o'clock line) can also be provided. In the package 10 according to FIG. 4 are two medications from different manufacturers put together. The package 10 according to FIG. 5 individually provides the patient with three different products (drug I from manufacturer A, drug II from manufacturer B and drug III from manufacturer C) from three different manufacturers. In addition, another drug I from manufacturer A with the same active ingredient in a lower dosage (administration time 20.00 clock) is part of the packaging 10. The way of compilation is therefore arbitrary (freely programmable) and can be supplemented for example by additional vitamin supplements, dietary supplements, etc. ,

In the FIG. 7 For example, an apparatus 27 for producing the described packages 10 is shown. The device 27 has a transport element 28 for transporting individual blanks 29, which form the substrates 14, through the device 27 and past a placement head 30. Preferably, on both sides of the transport element 28, but also on one side receiving spaces 31 are provided for rollers 32, magazines or the like, wherein the rollers 32, magazines or The like preferably carry rolled blister straps for the products 11. The placement head 30 is preferably arranged centrally and serves for transporting the product carrier 16 or sections 17 separated from the blister strip from a supply position 33 to the delivery position on the substrate 14. The device 27 comprises for each receiving space 31 a release agent by means of which the product carrier 16 or Sections 17 can be separated from the blister strip. In the transport direction T at the output of the device 27, a printing station 34 is arranged, by means of which the information 12, 13, 23 can be placed on the packaging. The placement head 30 has several axes of motion (linear X, Y, Z axis and axis of rotation) and is optionally also linear and / or movable on a circular path and has a controller for automatic and individual execution of the individual manufacturing orders. The placement head 30 is preferably connected to an optical reading device in order to check the correct recording of the sections 17 on-line by means of an optical code on the products 11 or the sections 17. For receiving and / or executing the orders, the device 27 can be networked and even be part of a network and thus, for example, integrated in a logistics system.

• An der Vorrichtung 27 sind mehrere Rollen 32 mit aufgerollten Blistergurten gerüstet,
• wobei jeder Blistergurt lediglich einen Produkttyp (gleicher Wirkstoff in gleicher Dosierung) trägt und jedes einzelne Produkt 11 separat in einem Nest 18 des Blistergurtes liegt. Der Vorrichtung 27 wird ein Zuschnitt 29, beispielsweise das Substrat 14 zugeführt. Diese Zuschnitte 29 können für Patientengruppen,
• Verpackungsgruppen (Wochenpackung, Monatspackung etc.) standardisiert und blanko oder vorgedruckt (z.B. mit Wochenkalender, Zeitskala oder dergleichen) ausgebildet sein. Der Vorrichtung 27 wird manuell oder automatisch ein Auftrag zur Herstellung einer Verpackung 10 gegeben, wobei der Auftrag die patientenspezifischen Daten (welches Medikament, welche Menge etc.) enthält. Sobald die Daten geladen sind, wird der Auftrag abgearbeitet, indem die Produkte 11 (eines oder mehrerer Hersteller und/oder einer oder mehrerer Dosierungen etc.) ausgewählt und von den Rollen 32 bzw.
• den vorkonfektionierten Produktträgern 16 abgeschnitten oder anderweitig getrennt werden. Die vom Gurt getrennten Produktträger 16 bzw. Abschnitte 17 werden dann zur Bereitstellungsposition 33 gefördert und dort durch den über mehrere Achsen (z.B. X-, Y-, Z-Achse) beweglichen Bestückkopf 30 aufgenommen und dem Substrat 14 zugeführt. Zuvor kann das Substrat 14 mit Klebepunkten oder dergleichen versehen worden sein, wobei sich die Positionen der Klebepunkte aus der Anordnung der zu bestückenden Abschnitte 17 auf dem Substrat 14 ergeben. Die Abschnitte 17 werden auf die Klebepunkte gesetzt, so dass eine feste Verbindung zwischen den Abschnitten 17 und dem Substrat 14 entsteht. Andere Verbindungstechniken sind ebenfalls möglich.
• Nach der vollständigen Bestückung des Substrats 14 wird die korrekte Bestückung und Platzierung jedes Abschnittes 17 mittels optischer Verfahren überprüft und sodann das Deckelement 21 aufgebracht, das separat zugeführt wird. Der durch das mit mehreren Abschnitten 17 bestückte Substrat 14 gebildete Blisterverbund 19 wird dann der Bedruckstation 34 zugeführt und mit den gewünschten Informationen versehen.
• Anschließend wird die Verpackung 10 versandfertig vorbereitet. Die in Abschnitte 17 zu unterteilenden Blistergurtverpackungen oder dergleichen können auch in entrollter, gefalteter, ungefalteter oder anderer Darreichungsform an der Vorrichtung 27 vorrätig sein und verarbeitet werden.

The method for producing the packaging 10 described above is explained in more detail below:

• On the device 27 a plurality of rollers 32 are equipped with rolled up blister straps,
• each blister strip carrying only one product type (same active ingredient in the same dosage) and each individual product 11 being located separately in a nest 18 of the blister strip. The apparatus 27 is fed with a blank 29, for example the substrate 14. These blanks 29 can be used for patient groups,
• Packing groups (weekly pack, monthly pack etc.) standardized and blank or pre-printed (eg with weekly calendar, time scale or the like) be formed. The device 27 is manually or automatically given an order for the production of a package 10, wherein the order contains the patient-specific data (which drug, what amount, etc.). Once the data is loaded, the order is processed by selecting the products 11 (one or more manufacturers and / or one or more dosages, etc.) and selecting them from the roles 32 or
• the pre-assembled product carriers 16 are cut off or otherwise separated become. The product carrier 16 or sections 17 separated from the belt are then conveyed to the supply position 33 and are picked up there by the placement head 30 which is movable over a plurality of axes (eg X, Y, Z axis) and fed to the substrate 14. Previously, the substrate 14 may have been provided with adhesive dots or the like, the positions of the adhesive dots resulting from the arrangement of the sections 17 to be loaded on the substrate 14. The sections 17 are placed on the adhesive dots, so that a firm connection between the sections 17 and the substrate 14 is formed. Other connection techniques are also possible.
• After the substrate 14 has been fully assembled, the correct placement and placement of each section 17 is checked by optical means and then the cover element 21 is applied, which is fed separately. The blister composite 19 formed by the substrate 14 populated with a plurality of sections 17 is then fed to the printing station 34 and provided with the desired information.
• Subsequently, the package 10 is prepared for shipment. The blister strip packs or the like to be subdivided into sections 17 may also be in stock on the device 27 in unrolled, folded, unfolded or other dosage form and processed.

Optionally, additional control and / or backup steps, e.g. be made by reading manufacturing, patient data or other information in the memory chip 25. By means of the coding 24 further testing or securing steps can be carried out. As described, the production of the packages 10 usually takes place automatically. In this case, job data (such as a recipe) can be fed directly to the device 27 and implemented by it. Usually, the method is computer-aided.

• Zur Versorgung von Patienten mit einem patientenindividuell für einen definierten Einnahmezeitraum zusammengestellten Bedarf an einem Medikament A und/oder einem Medikament B wird vorgeschlagen, das Medikament A in einer eine Vielzahl von jeweils separat eingehaust beabstandet zueinander angeordneten Exemplare EA des Medikamentes A tragenden Träger C und/oder das Medikament B in einer eine Vielzahl von jeweils separat eingehaust beabstandet zueinander angeordneten Exemplare EB des Medikamentes B tragenden Träger D bereitzustellen, vom Träger C Abschnitte CA mit einem oder mehreren Exemplaren EA des Medikamentes A und/oder vom Träger D Abschnitte DB mit einem oder mehreren Exemplaren des Medikamentes B abzutrennen und die abgetrennten Abschnitte CA und/oder DB in einer matrixartigen Formation auf einem Substrat einnahmekonform anzuordnen.

In abstract terms, the method can also be described as follows:

• For the supply of patients with a patient-specific for a defined period of intake compiled need for a drug A and / or a drug B, it is proposed that the drug A in a plurality of separately housed spaced apart each spaced specimens EA of the drug A carrying carrier C and / or the drug B in a plurality of each separately housed spaced from each other arranged copies EB of Provide drug B carrying carrier D to separate from the carrier C sections CA with one or more copies EA of the drug A and / or the carrier D sections DB with one or more copies of the drug B and the separated sections CA and / or DB in a matrix-like Formation on a substrate in accordance with income arrangement.

• Ein Verteilungszentrum stellt patientenspezifische Verpackungen her. Ein Auftraggeber liefert die für die Zusammenstellung der Verpackung notwendigen Informationen. Die Informationen können mündlich, schriftlich oder üblicherweise in elektronischer Form übermittelt werden. Als Auftraggeber können Patienten selbst fungieren, solange es sich um rezeptfreie und nicht apothekenpflichtige Produkte/Tabletten handelt. In der Regel enthalten die Informationen aber Rezeptdaten, die von einem Arzt erstellt und durch diesen oder durch eine Apotheke direkt an das Verteilungszentrum übermittelt werden.

With the above-described type of packaging as well as the method and the device 'for producing the packaging, a particularly efficient and cost-effective method for the distribution of pharmaceutical and / or medical products 11 or packaging 10 can be realized, which will be described in more detail below Example of tablets, for example, proceed as follows:

• A distribution center manufactures patient-specific packaging. A client supplies the information necessary for putting together the packaging. The information may be transmitted orally, in writing or usually in electronic form. Patients can be patients themselves as long as they are over-the-counter and non-pharmacy products / tablets. In general, however, the information contains prescription data that is created by a doctor and transmitted by this or by a pharmacy directly to the distribution center.

The tablets required for the collection of the desired content and quantity individual packaging can be supplied directly to the distribution center by different manufacturers. In the event that the tablets are delivered as raw materials to the distribution center, the distribution center fills the tablets themselves into blister straps so that the tablets are in pre-assembled blister straps for further processing. Each blister strip is assigned only a product of a specific active ingredient or a special combination of active ingredients with a special dosage. On the blister strip itself, only one tablet is assigned to each nest of the blister strip. The individual packaging 10 is then assembled from these prefabricated blister straps. For the usual case of pills being filled in blister straps directly at the actual producer of the tablets, the manufacturers deliver the blister straps to the distribution center.

Depending on the catchment or supply area, the distribution center is regionally oriented. This means that the distribution center ensures the assembly and delivery of the individual packaging in a locally defined area. There are usually several regional distribution centers that can be supplied directly by the manufacturers. However, it may also be provided a national, national or international distribution center. The parent distribution center receives the tablets from one or more manufacturers in turn as raw materials and / or packed in blister straps. The blister belts and the blister belts filled with the raw material from the distribution center are then delivered either directly to one or more regional distribution centers and / or to a logistics unit, whereby the logistics unit may also be divided into several smaller units.

Regardless of the delivery of the distribution center producing the packages 10, the latter has stockpiled the most common and most widely prescribed products 11 as well as the most widely used combination products. This means that on the basis of detailed information and empirical values, those preparations are needed that are needed for the compilation of individual packages. Even if individual products 11 should not be available in the distribution center, these products 11 can be obtained at short notice from the manufacturer and / or from the higher-level distribution center and / or from the logistics unit.

The clients can be networked with the distribution center to transfer orders. The transfer of information can also be done by conventional means by e-mail or in other usual computer-aided way. The incoming orders can be processed automatically and computer-controlled within the distribution center by means of suitable devices 27 by separating the selected products 11 from the stocked blister straps in a predetermined amount and depositing them on a blank 27, substrate 14 or the like supplied to the device 27. The resulting patient-specific blister composites or packaging 10 can then still before delivery labeled, coded or otherwise marked and tested, in particular also with electronic aids.

In addition, the distribution center is optionally also connected to the logistics unit and / or the parent distribution center and / or the manufacturers. This connection can be made by conventional means of communication or be ensured by networking. Also, several distribution centers can be networked together. Through the connections, in particular products 11 or blister belts can be supplied as required and / or order-controlled to the or each distribution center producing the packaging 10. Also, the stocking with the relevant products 11 or blister straps within the stations is easy to make sure.

The produced packaging 10 can be delivered by the distribution center itself or by the logistics unit quasi as a courier service to the client, for example a pharmacy or directly to the patient.

Claims (11)

1. Pack (10) for pharmaceutical and/or medical products (11) and/or food supplements, comprising a substrate (14) which is fitted with one or more prefabricated, sealed product carriers (16) which each contain one or more isolated products (11), for a given length of time, and is provided with instructions for application or administration time for the patient, wherein each product carrier (16) exclusively contains products (11) of a special active ingredient or a special combination of active ingredients in a special dosage, characterised in that each product carrier (16) forms part of a single-strip blister pack that can be rolled up, and the product carriers (16) each containing one or more isolated products (11) are assembled on the substrate (14) individually to the patient, wherein the substrate (14) carries or forms a blister composite (19), such that several sections (17), having at least one nest (18), of the product-specific blister strip packs each with different isolated products (11) of an active ingredient or combination of active ingredients from one or more manufacturers are applied to the substrate (14), wherein the product carriers (16) lie with one side on the substrate (14) and on the other side are at least partially covered by a separately delivered covering element (21).
2. Pack according to claim 1, characterised in that in each nest (18) of each blister strip pack or of each section (17) of the blister strip packs is arranged precisely one product (11).
3. Pack according to claim 1 or 2, characterised in that the product carriers (16) or sections (17) are rigidly connected to the substrate (14).
4. Pack according to any of claims 1 to 3, characterised in that the substrate (14) is releasably mounted on a surrounding pack.
5. Pack according to any of claims 1 to 4, characterised in that the substrate (14) is assigned an electronic component (25) for the storage of data and/or information.
6. Method for the manufacture of a pack for pharmaceutical and/or medical products (11) and/or food supplements, with the following steps:

   - preparing a substrate (14),

   - selecting patient-individual products (11) for a given period of time,

   - separating prefabricated, sealed product carriers (16) with the selected patient-individual products (11) from single-strip blister packs that can be rolled up, each product carrier (16) carrying only one or more isolated products (11) of a special active ingredient or special combination of active ingredients in a special dosage,

   - automatically positioning and fixing the separated product carriers (16) on the substrate (14) according to the data individual to the patient, wherein a blister composite (19) is formed by applying several sections (17) of the product-specific blister strip packs, wherein the blister composite (19) is formed from product carriers (16) with products (11) from different manufacturers, wherein then on the substrate (14), a separately delivered covering element (21) is applied to the substrate (14) so that the or each product carrier (16) is arranged between the covering element (21) and the substrate (14).
7. Method according to claim 6, characterised in that the or each product carrier (16) is glued to the substrate (14).
8. Method according to claim 6 or 7, characterised in that manufacturing and/or product information is read into an electronic component (25) of the substrate.
9. Method according to any of claims 6 to 8, characterised in that selection of the patient-individual products (11) takes place with reference to a prescription.
10. Method according to claim 9, characterised in that the patient information is passed with the respective individual medication directly from the doctor or a pharmacy or a hospital or other authorised persons online to an apparatus (27) for assembling the pack (10).
11. Apparatus for the manufacture of a pack according to any of claims 1 to 5, including a transport element (28) for delivering and removing individual substrate (14)-forming blanks (29), holding positions (31) for blister strips in which the products (11) are arranged in isolation and sealed, each holding position (31) being assigned a separating means for separating the product carriers (16) or the sections (17) from the blister strip, and a mounting head (30) for transporting the product carriers (16) or sections (17) separated from the blister strip from a preparing position (33) to the discharge position on the substrate (14), wherein the apparatus is designed and arranged for delivering separate covering elements.

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