EP1956999A2 - Appui d'attelle sur un implant osteo-integre et coiffe inclinee de maniere compensatrice - Google Patents

Appui d'attelle sur un implant osteo-integre et coiffe inclinee de maniere compensatrice

Info

Publication number
EP1956999A2
EP1956999A2 EP06804601A EP06804601A EP1956999A2 EP 1956999 A2 EP1956999 A2 EP 1956999A2 EP 06804601 A EP06804601 A EP 06804601A EP 06804601 A EP06804601 A EP 06804601A EP 1956999 A2 EP1956999 A2 EP 1956999A2
Authority
EP
European Patent Office
Prior art keywords
splint
implant
abutment
splint abutment
compensatory slanted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06804601A
Other languages
German (de)
English (en)
Other versions
EP1956999A4 (fr
Inventor
Branca Fraga De Resende Chaves
Maria Auxiliadora Mourão MARTINEZ
Luciana Silva Colepicolo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ITP Instituto de Tecnologia e Pesquisa Ltda
Original Assignee
ITP Instituto de Tecnologia e Pesquisa Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ITP Instituto de Tecnologia e Pesquisa Ltda filed Critical ITP Instituto de Tecnologia e Pesquisa Ltda
Publication of EP1956999A2 publication Critical patent/EP1956999A2/fr
Publication of EP1956999A4 publication Critical patent/EP1956999A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
    • A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
    • A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
    • A61C8/006—Connecting devices for joining an upper structure with an implant member, e.g. spacers with polygonal positional means, e.g. hexagonal or octagonal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
    • A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
    • A61C8/0068—Connecting devices for joining an upper structure with an implant member, e.g. spacers with an additional screw
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
    • A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
    • A61C8/0069—Connecting devices for joining an upper structure with an implant member, e.g. spacers tapered or conical connection
    • A61C8/0071—Connecting devices for joining an upper structure with an implant member, e.g. spacers tapered or conical connection with a self-locking taper, e.g. morse taper

Definitions

  • the present invention is related to a splint abutment for dental a prosthesis that can be made of titanium, gold, carbon, chromium-cobalt, tilite, zirconium, niobium, alumina, and other similar materials, without restriction. It is a splint abutment for implant-supported prosthesis that makes it possible to place two prosthetic crowns over a single implant, thus providing better biomechanics, normal dental function, good aesthetics and hygienic cleaning of prostheses.
  • This invention offers superior resistance of the abutment, lasting aesthetics and a reduction in clinical time, assuring more predictable results .
  • the aesthetic and functional necessities of lost teeth replacement have been the primary focus in oral rehabilitation.
  • the introduction of the osseointegrated implants increased the possibility of supplying fixed, predictable and functional restorations, mainly in extensive edentulous sites.
  • teeth replacement treatment initially concentrated its function and success on the medium and long-term, but new necessities have brought about discussions and more appropriate treatment planning, providing greater predictability in the final results.
  • the dental osseointegrated implants offered by the technology available in the market receive a single abutment on which a single crown element is placed.
  • an inlay splint prosthetic bar is made, and/or a metallic infra structure fused and welded, joining two or more osseointegrated implant abutments, according to the planning of the edentulous site.
  • This inlay splint procedure presents some disadvantages, such as the difficulty in cleaning, the aesthetic problems due to the absence of the prefabricated "abutment" with sinuous format, that follows gingival contour and that provides a more flattened in the mesiodistal direction and lengthened in the buccolingual direction and presents greater similarity to the form of a natural tooth, unlike those currently in the market.
  • the cylindrical format of the available abutment in the state of the technique provides less nesting stability and retention of the prosthetic crown, compared to the innovation described herein. This hinders a uniform motion of the normal dental function forces in the longitudinal direction of the implant, as occurs in the resulting forces of a natural tooth, which could also cause stress concentration in the neck of the implant and bring about bone loss the surrounding area. All the disadvantages identified above have serious consequences in the effectiveness of the treatment, in the medium and long-term.
  • the invention patent BR PI9602881-5 presents a thin profile dedicated to very sensitive bone structures, in order to keep the temporary prosthesis attached throughout the process of osseointegration of the definitive implants.
  • the patent of utility model MU7801874- 9 is designed to make it easier to implant the prosthesis with a fast and safe attachment to the bone. Its object consists of a cylindrical piece of pure titanium, with a highly polished external ring band at one end, thus better adapting to the gum, and a threaded blind bore, centered in the longitudinal direction, which is larger and hexagonal in the apical third, facilitating the fitting of proper tools for threading the implant in the bone.
  • the prominent bone overload is clear and the probable future perimplantitis caused by the bone overload, which could expose the inter- bone part of the implant in contact with the subgingival microbiota, possibly causing future implant loss.
  • the rose aesthetic of the gum should hug the prosthetic white crown to achieve the best result of aesthetic excellence in implant-supported work.
  • the invention described here presents a splint abutment that makes it possible to place two dental elements in a single implant, thus providing better normal dental function, aesthetic stability and oral hygienic maintenance.
  • the innovation described here provides greater nesting stability and retention of the prosthetic crown, bringing about better directing of normal dental function forces in the axial of the implant, as it occurs with natural tooth forces, where the tensions are equally distributed, diminishing the concentration of tensions on the neck of the implant.
  • the new design presented by the invention described here allows greater stability, retention and directing of prosthesis forces for the axial forces of the implant,, ⁇ since the adaptation of the prosthetic crown occurs in the divergent girdle and not in the neck of the implant, thus presenting more favorable and appropriate biomechanical properties by allowing an emergency profile more similar to the natural tooth.
  • the present invention provides better marginal sealing, as well as better hygienic cleaning, since the nesting of the prosthetic crown occurs above of the implant neck, in the divergent girdle of the pre-manufactured abutment, which can still be re-preparable, adjusting the prosthetic emergency profile according to the contour shape of the gingival architecture.
  • the splint abutment has parallel, slightly flared pins for the normal dental function, with convergence degree of 6° to 9°, and they form angles between 30° and 60° with the insertion axis of the implant, conforming with the emergency profile of the gingival papilla.
  • the abutment possesses a neck or divergent marginal girdle of adjustable height of 1.0 mm to 8.0 mm, and changeable perimeter between 4.5 mm and 14.0 mm, in the mesiodistal direction and buccolingual perimeter of 4.0 mm to 9.0 mm, from where two pins protrude with height, also adjustable, of between 2.0 mm and 13.5 mm, and changeable, .diameter of 1.0 mm to 8.0 mm, according to the edentulous site.
  • pins are parallel to themselves, slightly flared for normal dental function, with a chanfered area in all its cervical ending, that is, bevel deep chanfer or shoulder with rounded axio-pulpar angle, which can be pre- manufactured and repreparable for individualization of the piece according to the architecture of the gingival contour. Between the pins there is a narrow channel or milling area that can be located either in the vestibular or in the lingual position, to confer greater retention and stability to the splint abutment.
  • the splint abutment, object of the present invention can, when necessary, be separated into two parts, separating the pins from the marginal girdle and then fitting them together to assemble them.
  • the dismemberment of this abutment can also occur in the splint abutment coupling base, in cases of inclination correction of the implant in the mesio-distal or buccolingual directions, ' rotationally, where the use of a connected cylindrical part is necessary, that is, a compensating slanted cap that provides an inclined plane, varying from between 0° to 35°, to adjust the "abutment" position according to each case, providing greater possibility for correction of the rotational angles.
  • a compensating slanted cap that provides an inclined plane, varying from between 0° to 35°
  • the compensatory slanted coping which will be fitted between the implant and the splint abutment, is characterized by being a specific piece made of the same material as the abutment, with a perforation where the fixation screw of the XN abutment" will pass.
  • the height of the inclination slant can vary in accordance with the angle from between 0° and 35°, rotational, which will determine the compensatory and corrective slant.
  • the screw of the splint abutment must be sufficiently large, in height, to compensate the height of the compensatory slanted coping.
  • the splint abutment provides an opening between the bolts of 2.1 mm to 5.5 mm, designed to make it possible to insert the axis of the abutment screw, when the coupling part is needed, that is, the compensatory slanted coping. Besides the functional, operational and aesthetic advantages of these alternatives, they also speed up, facilitate and simplify the process of industrial production of the parts, as to reduce its final cost .
  • the compensatory slanted coping will be connected in the vertical direction, with the same inclination compensation varying from between 0° to 35°.
  • the splint abutment, object of the present invention also presents the inclination compensation of the implants set on the bone ridge, with a single part, with a variation between 10° and 35° with the implantation insertion axis.
  • the multidimensional angled splint abutment still offers the alternative of being repreparable, accordance to the availability of the gingival architecture, and offers a flexibility of shape for greater effectiveness of the of the implant result, as well as for greater comfort and patient adaptation.
  • the pins are parallel, slightly flared for the occlusal and form angles between 30° and 60° with the neck, in accordance with the emergency profile of gingival papilla. They possess a chanfer area, or deep chanfer, or shoulder with axio-cervical angle rounded in its entire, ⁇ perimeter, following the edge of the profile of natural emergency provided by periodontium support.
  • the peripheral and internal gingival contour is obtained by means of making a prefabricated coping for splint abutment, or by making moldings, for cases of repreparable splint abutments, providing an anatomical contour similar to natural teeth.
  • the splint abutment can present a narrowing at the base of the cervical divergent brace, in all its perimeter of 0.7 mm to 2.0 mm for gingival biological space between the platform of the implant and the splint abutment.
  • the present invention innovates the state of the art, since it offers a product that makes it possible, in a single osseointegrated implant, whether of external hexagon, internal hexagon, internal octagon, Morse cone and cold welding, to place two dental elements conjugated or inlay splint, with the option for cemented or screwed prosthesis in cases of edentulous sites up to 15.0 mm, for cases that present anatomical or surgical variations that prevent placing two implants.
  • the invention described here offers better aesthetic, marginal sealing, oral hygiene maintenance, greater normal dental function stability, total passivity for being free of welding points, as well as a reduction in treatment time and a simplification of the clinical and prosthetic procedures.
  • the present innovation also aims to present individualized splint abutments solutions, for the posterior or anterior region, besides corrective abutments according to the positioning or topography of periodontium.
  • the splint abutment also offers a solution for placing a single element, with wide or small diameter, whose edentulous site is up to 10.0 mm, the mesiodistal or buccolingual, since it provides a much more natural emergency profile, that is, more similar to the original tooth. It also favors proper oral hygiene maintenance and offers much more suitable and satisfactory biomechanical properties. There is, moreover, the possibility of varied positioning of the splint abutment to naturally follow the individualized emergency profile, since it presents adjustable dimensions and chanfers that follow the convex / concavous profile of the gingival tissue.
  • a further embodiment of the present invention is related to small variations, mainly in relation to the dimensions, and greater detailing of splint abutment and compensatory slanted coping.
  • the product of this additional embodiment makes it possible to place two inlay splint prosthetic elements in a single osseointegrated implant, in edentulous sites of up to 16.0 mm, for cases in which anatomical or surgical variations occur that prevent the insertion of two implants.
  • the splint abutment provides better marginal sealing, as well as better oral hygiene maintenance; therefore the passive nesting of the splint abutment occurs in the platform of the implant.
  • the adaptation of the prosthetic crown is done above this platform, that is, in the divergent girdle of the prefabricated splint abutment, repreparable .
  • the gingival architecture can be adjusted and individualized in accordance with the contour shape and the gingival architecture, adjusting itself to the height of its sinuosity, to the sizes and height of the divergent cervical, buccal and lingual girdle, of 0.5 mm to 10.0 mm, and of the divergent interproximal cervical girdle, from 1.0 mm to 12.0 mm, adjusting the emergency profile of the prosthetic.
  • the splint abutment has two parallel pins, slightly flared for the normal dental function, with a convergence degree of 4° to 30° with the insertion axis of the prosthetic crown and forming angles of 8° and 60° between themselves, and it is possible to merge them in cases where the edentulous site is less than 10 mm. They have a chanfer area, or deep chanfer, or shoulder with axio-cervical angle rounded along its entire perimeter, following the border of the natural emergency profile presented by periodontal.
  • the divergent girdle forms angles between 30° and 80° with the axial forces of implant setting, determined by the anatomical contour of the gingival papilla, with the option of using a cemented prosthesis, individualized or not.
  • the splint abutment could be reprepared to directly receive the selected restoring material or even to receive fused ceramics directly in the splint abutment.
  • the splint abutment possesses a neck or divergent marginal girdle of adjustable height from 1.0 mm to 8.0 mm, and a variable length between 3.0 mm and 14.0 mm both in the mesiodistal and in the buccolingual direction, from where two pins protrude, also with adjustable heights, between 2.0 mm and 13,5 mm, and variable diameter of 1.0 mm to 8.0 mm, determined by the edentulous site.
  • the open area could be differentiated by being lingualized in relation to the parallel pins in the anterior elements, and in the posterior elements, for overlap cases.
  • the open area, where the splint abutment screw is fixed, can also be differentiated, because it coincides with the positioning place of one of the parallel pins, allowing an extension of up to 55 mm of the divergent girdle, both for mesial and for distal.
  • the compensatory slanted coping which will be fit between the implant and the splint abutment, is characterized for being a specifically made piece with the same material of the abutment, non-restrictive, with a perforation through which the screw of the "abutment" setting will pass.
  • the height of the compensatory slanted coping can vary in accordance to the angle between 0° and 50°, rotational, which will determine the compensatory and corrective slant.
  • the screw of the splint abutment must be large enough, in height, to compensate the height of the compensatory slanted coping.
  • the splint abutment presents an opening between the bolts of 2.1 mm to 5.5 mm, designed to make it possible to insert the axis of the abutment screw, when the coupling piece is needed, that is, of the inclination plane. Besides the functional, operational and aesthetic advantages of these alternatives, they not only speed up, facilitate and simplify the process of industrial production of the pieces, but they also reduce the final cost.
  • the compensatory slanted coping will be connected in the vertical direction, with the same compensation of inclinations varying from 0° to 50°.
  • the splint abutment, object of the present invention also presents the inclination compensation of the implants set on the bone ridge, in a single piece, with variation between 10° and 60° with the implant insertion axis.
  • the multidimensional angled splint abutment furthermore provides the alternative of being repreparable, offering a shape flexibility to allow greater effectiveness of the implantation result, as well as greater comfort and adaptation for the patient.
  • the peripheral and internal gum contour of the prosthetic crown is obtained by making the pre-manufactured coping for splint abutment, or by making moldings.
  • it provides anatomical contour, similar to natural teeth or even by means of sculpture and fused ceramics directly on the splint abutment, eliminating molding, casting and welding stages, reducing the laboratorial clinical time as well as final cost.
  • Figure 1 shows the plant or view from above the implant where: (1) is the mesiodistal distance that varies from 4.5 mm to 14.0 mm; (2) is the buccolingual distance that varies from 4.0 mm to 9.0 mm; (3) is the diameter of the base of the pins that varies from 2.5 mm to 6.0 mm; (4) is the diameter of the top of the pins that varies from 2.0 mm to 4.0 mm; (5) is the space between the two the pins that varies from 2.1 mm to 5.5 mm.
  • Figure 2 shows the front view of the implant where: ( ⁇ ) is the mesiodistal distance that varies from 4.5 mm to 14.0 mm; (7) is the height of the pins from 2.0 mm to 13.5 mm; (8) is the height of the cervical interproximal divergent girdle that varies from 1.0 mm to 6.0 mm; (9) is the abutment height that varies from 4.0 mm to 14.5 mm; (10) is the height of the buccal and/or lingual divergent cervical girdle that varies from 1.0 mm to 5.0 mm.
  • Figure 3 shows the lateral view of the implant where: (2) is the buccalingual distance that varies form 4.1 mm to 9.0 mm; (8) is the height of the divergent cervical girdle that varies from 1.0 mm to 6.0 mm; (10) is the height of the buccal and/or lingual divergent cervical girdle that varies from 1.0 mm to 5.0 mm.
  • Figure 4 shows all items that make up the splint abutment
  • (11) are the prosthetic crowns
  • (12) are the parallel pins
  • (13) is the divergent girdle
  • (14) is the compensatory slanted coping
  • (15) is the implant
  • (16) is the splint abutment and (17) are the splint abutments on the implant with and without the compensatory slanted coping
  • (17) is the splint abutment, and the prosthetic crown, on the implant in the correct position (a) , and without the inclination slant (b) .
  • the invention presented here justifies its protection for both its innovative character and for the great contribution to the technological development in the medical-odontologic sector, since this invention can also be used for osseointegrated implants in other medical areas.

Landscapes

  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dentistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dental Prosthetics (AREA)
  • Dental Preparations (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

La présente invention concerne un appui d'attelle pour une réhabilitation prothétique qui est constitué de divers types de matériaux et qui est relié à un implant ostéo-intégré. Cet appui d'attelle pour une prothèse montée sur implant permet de placer deux couronnes prothétiques sur un seul implant, offrant ainsi de meilleures caractéristiques biomécaniques, de meilleures caractéristiques d'étanchéité en bordure, une meilleure stabilité occlusale, de meilleures caractéristiques esthétiques et de meilleures caractéristiques pour l'entretien de l'hygiène dentaire de la prothèse dentaire. Les possibilités biomécaniques de cette invention permettent d'obtenir une plus grande stabilité occlusale puisque la forme et le contour de l'appui d'attelle répartissent et absorbent de manière partielle les forces de mastication d'une façon plus équilibrée par rapport aux forces axiales. Cette invention concerne également l'inclinaison, constituée du même matériau que l'appui non restrictif, à adopter entre l'implant et l'appui d'attelle, afin d'ajuster la position de l'appui en fonction des besoins de correction des angulations de rotation et multidirectionnelle des implants. Cette invention permet d'obtenir une meilleure résistance de l'attelle grâce audit appui d'attelle, des caractéristiques esthétiques durables et un temps de soin clinique réduit, tout en assurant une plus grande prévisibilité des résultats.
EP06804601A 2005-11-23 2006-11-03 Appui d'attelle sur un implant osteo-integre et coiffe inclinee de maniere compensatrice Withdrawn EP1956999A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BRPI0505827A BRPI0505827B8 (pt) 2005-11-23 2005-11-23 pilar geminado sobre implante osseointegrado e corretivo extensor compensatório de inclinações
BRC10505827 2006-10-02
PCT/BR2006/000243 WO2007059595A2 (fr) 2005-11-23 2006-11-03 Appui d'attelle sur un implant osteo-integre et coiffe inclinee de maniere compensatrice

Publications (2)

Publication Number Publication Date
EP1956999A2 true EP1956999A2 (fr) 2008-08-20
EP1956999A4 EP1956999A4 (fr) 2013-01-23

Family

ID=38067560

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06804601A Withdrawn EP1956999A4 (fr) 2005-11-23 2006-11-03 Appui d'attelle sur un implant osteo-integre et coiffe inclinee de maniere compensatrice

Country Status (4)

Country Link
EP (1) EP1956999A4 (fr)
BR (1) BRPI0505827B8 (fr)
CA (1) CA2630592C (fr)
WO (1) WO2007059595A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0705570B8 (pt) 2007-05-24 2021-06-22 Itp Inst De Tecnologia E Pesquisa Ltda sistema de corretivos compensatórios de inclinações, conversores e extensores e de pilares de acoplamento universal sobre implantes osseointegrados
US9301818B2 (en) 2010-10-07 2016-04-05 Bredent Gmbh & Co. Kg Abutment and dental-prosthetic arrangement having such an abutment
CN106031664B (zh) * 2015-03-09 2019-08-16 福建省级机关医院 口腔种植修复的消极吻合工艺
CA3083178A1 (fr) * 2017-11-14 2019-05-23 Luciana Silva Colepicolo Systeme de trois piliers avec connexion t

Citations (2)

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US4522596A (en) * 1984-01-20 1985-06-11 Ashkinazy Larry R Modular implant assembly
DE19753577A1 (de) * 1997-12-03 1999-06-17 Ralf Dr Schroeder Atraumatisches, geschlossenes Kieferschraubenimplantat

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US4360342A (en) * 1980-11-12 1982-11-23 Salvo Christopher A Method for replacing lost teeth
BR7400850U (pt) 1994-06-13 1996-01-09 Lorenzo Ager De Kit para implante ósseo-integrado utilizado na fixação de prótese dentária
BR7900158U (pt) 1999-01-29 2000-10-24 Garsa Assessoria E Participaco Placa polimérica para fixação óssea
US6592370B2 (en) * 2000-09-14 2003-07-15 Diro, Inc. Abutment for dental implant and associated components for use therewith
JP2002282281A (ja) * 2001-03-22 2002-10-02 Aichi Steel Works Ltd 義歯アタッチメント
DE10358680A1 (de) * 2003-02-05 2005-07-07 Neumeyer, Stefan, Dr. Abutment für ein Zahnimplantat, Zahnimplantat mit einem solchen Abutment sowie Verfahren zum Herstellen von Zahnersatz unter Verwendung des Zahnimplantats

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US4522596A (en) * 1984-01-20 1985-06-11 Ashkinazy Larry R Modular implant assembly
DE19753577A1 (de) * 1997-12-03 1999-06-17 Ralf Dr Schroeder Atraumatisches, geschlossenes Kieferschraubenimplantat

Non-Patent Citations (1)

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Title
See also references of WO2007059595A2 *

Also Published As

Publication number Publication date
WO2007059595A3 (fr) 2009-04-23
CA2630592A1 (fr) 2007-05-31
BRPI0505827B1 (pt) 2020-02-04
BRPI0505827B8 (pt) 2021-06-22
WO2007059595A2 (fr) 2007-05-31
CA2630592C (fr) 2015-10-20
BRPI0505827A (pt) 2007-08-14
EP1956999A4 (fr) 2013-01-23

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