EP1954243A2 - Methode de preparation de liposomes et utilisations - Google Patents

Methode de preparation de liposomes et utilisations

Info

Publication number
EP1954243A2
EP1954243A2 EP06809790A EP06809790A EP1954243A2 EP 1954243 A2 EP1954243 A2 EP 1954243A2 EP 06809790 A EP06809790 A EP 06809790A EP 06809790 A EP06809790 A EP 06809790A EP 1954243 A2 EP1954243 A2 EP 1954243A2
Authority
EP
European Patent Office
Prior art keywords
liposome
liposomes
lipid
agent
forming lipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06809790A
Other languages
German (de)
English (en)
Inventor
Yechezkel Barenholz
Olga Garbuzenko
Keren Barhum
Gilbert Grant
Boris Piskoun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
New York University NYU
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
New York University NYU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem, New York University NYU filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Publication of EP1954243A2 publication Critical patent/EP1954243A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

La présente invention concerne une méthode simplifiée et rentable de préparation de liposomes, ladite méthode consistant à utiliser un lipide sec de formation de liposomes ou un mélange sec comprenant un lipide de formation de liposomes, à dissoudre le lipide de formation de liposomes ou ledit mélange comprenant un lipide de formation de liposomes de l'étape (a) avec un solvant organique protique pour obtenir une solution ou une dispersion dudit lipide; et à ajouter la solution ou dispersion de l'étape (b) dans une solution aqueuse contenant des ions pour former une suspension de liposomes, les liposomes pouvant encapsuler un agent avec un rapport supérieur à 1,0 entre l'agent et le lipide de formation des liposomes. Le procédé de l'invention se caractérise en ce qu'il n'est pas nécessaire de sécher la solution ou la dispersion pour former un film lipidique sec, et/ou réduire la dimension des liposomes dans ladite suspension de liposomes pour former de petites vésicules unilaméllaires (SUV). Les liposomes ainsi formés peuvent alors être utilisés pour recevoir un agent actif, par exemple des médicaments amphipatiques à base d'acide faible.
EP06809790A 2005-10-26 2006-10-26 Methode de preparation de liposomes et utilisations Withdrawn EP1954243A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73004505P 2005-10-26 2005-10-26
PCT/IL2006/001229 WO2007049278A2 (fr) 2005-10-26 2006-10-26 Methode de preparation de liposomes et utilisations

Publications (1)

Publication Number Publication Date
EP1954243A2 true EP1954243A2 (fr) 2008-08-13

Family

ID=37968217

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06809790A Withdrawn EP1954243A2 (fr) 2005-10-26 2006-10-26 Methode de preparation de liposomes et utilisations

Country Status (5)

Country Link
EP (1) EP1954243A2 (fr)
JP (1) JP2009513621A (fr)
AU (1) AU2006307460A1 (fr)
CA (1) CA2627657A1 (fr)
WO (1) WO2007049278A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5107573B2 (ja) 2003-04-25 2012-12-26 ザ ペン ステイト リサーチ ファウンデーション 増殖抑制性脂質由来生物活性化合物の全身送達方法およびシステム
KR20110110086A (ko) * 2008-12-24 2011-10-06 가부시키가이샤 바이오메드코어 리포솜의 제조방법 및 콜레스테롤의 용해방법
EP2531175A2 (fr) * 2010-02-01 2012-12-12 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Liposomes comprenant des médicaments amphipathiques et procédé pour leur préparation
WO2012058483A1 (fr) * 2010-10-28 2012-05-03 Pacira Pharmaceuticals, Inc. Formulation à libération prolongée d'un médicament anti-inflammatoire non-stéroïdien
RU2571077C2 (ru) * 2011-03-25 2015-12-20 Терумо Кабусики Кайся Липосомальная композиция длительного действия с контролируемым высвобождением и способ ее получения
JPWO2014046191A1 (ja) * 2012-09-21 2016-08-18 テルモ株式会社 局所麻酔薬持続徐放性リポソーム製剤
SG10201707474XA (en) 2013-03-15 2017-10-30 Taiwan Liposome Co Ltd Engineering a control drug release profile via liposome composition in both aqueous and non-aqueous compartments
US10220095B2 (en) 2013-03-15 2019-03-05 Taiwan Liposome Company, Ltd Controlled drug release liposome compositions and methods thereof
CN104906586A (zh) * 2014-03-10 2015-09-16 中国科学院上海药物研究所 一种盐酸伊立替康复合磷脂组合物、制备方法及其应用
JP6866060B2 (ja) * 2014-10-27 2021-04-28 花王株式会社 精製茶抽出物の製造方法
WO2016191547A1 (fr) * 2015-05-26 2016-12-01 Comfort Care For Animals Llc Chargement de liposome
CN106619516B (zh) * 2016-10-10 2020-07-03 常州金远药业制造有限公司 一种小分子靶向药物脂质体制剂的制备方法
CN109983013A (zh) 2016-11-18 2019-07-05 帕西拉制药有限公司 美洛昔康锌复合物微粒多囊脂质体制剂及其制备方法
EP3658134A4 (fr) * 2017-07-24 2021-05-05 Pharmosa Biopharm Inc. Compositions de liposomes comprenant des médicaments à base d'acide faible et utilisations de celles-ci
SG11202011045VA (en) * 2018-05-07 2020-12-30 Pharmosa Biopharm Inc Pharmaceutical composition for controlled release of treprostinil

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485054A (en) * 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US5169637A (en) * 1983-03-24 1992-12-08 The Liposome Company, Inc. Stable plurilamellar vesicles
GB8322178D0 (en) * 1983-08-17 1983-09-21 Sterwin Ag Preparing aerosol compositions
SE8603812D0 (sv) * 1986-09-12 1986-09-12 Draco Ab Administration of liposomes to mammals
US5702722A (en) * 1994-09-30 1997-12-30 Bracco Research S.A. Liposomes with enhanced entrapment capacity, method and use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2007049278A3 *

Also Published As

Publication number Publication date
AU2006307460A1 (en) 2007-05-03
WO2007049278A2 (fr) 2007-05-03
JP2009513621A (ja) 2009-04-02
WO2007049278A3 (fr) 2007-09-13
CA2627657A1 (fr) 2007-05-03

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