EP1940787A4 - Nouveaux inhibiteurs de l'ido et leurs procedes d'utilisation - Google Patents
Nouveaux inhibiteurs de l'ido et leurs procedes d'utilisationInfo
- Publication number
- EP1940787A4 EP1940787A4 EP06844228A EP06844228A EP1940787A4 EP 1940787 A4 EP1940787 A4 EP 1940787A4 EP 06844228 A EP06844228 A EP 06844228A EP 06844228 A EP06844228 A EP 06844228A EP 1940787 A4 EP1940787 A4 EP 1940787A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- ido inhibitors
- novel ido
- novel
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/14—Dithiocarbamic acids; Derivatives thereof
- C07C333/18—Esters of dithiocarbamic acids
- C07C333/20—Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/14—Dithiocarbamic acids; Derivatives thereof
- C07C333/18—Esters of dithiocarbamic acids
- C07C333/22—Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73070605P | 2005-10-27 | 2005-10-27 | |
PCT/US2006/042137 WO2007050963A1 (fr) | 2005-10-27 | 2006-10-27 | Nouveaux inhibiteurs de l'ido et leurs procedes d'utilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1940787A1 EP1940787A1 (fr) | 2008-07-09 |
EP1940787A4 true EP1940787A4 (fr) | 2009-07-01 |
Family
ID=37968157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06844228A Withdrawn EP1940787A4 (fr) | 2005-10-27 | 2006-10-27 | Nouveaux inhibiteurs de l'ido et leurs procedes d'utilisation |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP1940787A4 (fr) |
WO (1) | WO2007050963A1 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7705022B2 (en) | 2005-10-27 | 2010-04-27 | Lankenau Institute For Medical Research | IDO inhibitors and methods of use thereof |
CA2932121A1 (fr) | 2007-11-30 | 2009-06-11 | Newlink Genetics Corporation | Inhibiteurs de l'ido |
GB0806794D0 (en) * | 2008-04-15 | 2008-05-14 | Ludwig Inst Cancer Res | Therapeutic compounds |
WO2010020676A1 (fr) * | 2008-08-20 | 2010-02-25 | Vib Vzw | Utilisation d’inhibiteurs de la topoisomérase de type i pour traiter des infections virales |
CN102234271B (zh) | 2010-04-21 | 2015-06-10 | 北京大学 | 芳杂(烷基)氨基二硫代甲酸酯类化合物、其制备方法和应用 |
CN102180845B (zh) * | 2011-03-29 | 2013-06-05 | 郑州大学 | 含丁烯内酯结构的苄氨基二硫代甲酸酯类化合物、其制备方法及其用途 |
CN103508930B (zh) * | 2012-06-25 | 2016-01-27 | 北京大学 | 双(氨基二硫代甲酸)-1,3-丙二酯类化合物及其合成方法、药物组合物和用途 |
WO2015121812A1 (fr) | 2014-02-12 | 2015-08-20 | Iteos Therapeutics | Dérivés de 3-(indol-3-yl)piridine, compositions pharmaceutiques et procédés d'utilisation |
CA2942761A1 (fr) * | 2014-03-18 | 2015-09-24 | Iteos Therapeutics | Derives substitues par 3-indole, compositions pharmaceutiques et procedes d'utilisation |
WO2015173764A1 (fr) | 2014-05-15 | 2015-11-19 | Iteos Therapeutics | Dérivés de pyrrolidine -2,5-dione, compositions pharmaceutiques et procédés pour une utilisation en tant qu'inhibiteursde de ido1 |
US10525035B2 (en) | 2014-12-18 | 2020-01-07 | Lankenau Institute For Medical Research | Methods and compositions for the treatment of retinopathy and other ocular diseases |
WO2016149404A1 (fr) | 2015-03-16 | 2016-09-22 | California Institute Of Technology | Agents de capture spécifiques de la neurotoxine botulique, compositions et méthodes d'utilisation et de préparation associées |
AU2016231832B2 (en) * | 2015-03-17 | 2019-09-19 | Pfizer Inc. | Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use |
EP3334733A1 (fr) | 2015-08-10 | 2018-06-20 | Pfizer Inc | Dérivés substitués par un 3-indole, compositions pharmaceutiques et leurs procédés d'utilisation |
EP3519425B1 (fr) * | 2016-09-29 | 2024-02-28 | Indi Molecular, Inc. | Compositions pour la détection, l'inhibition et l'imagerie de l'indoléamine 2,3-dioxygénase 1 (ido1) et leurs méthodes de production et d'utilisation |
CN106966978B (zh) * | 2017-03-05 | 2020-06-26 | 北京化工大学 | 一种酰胺类化合物及其制备方法和用途 |
CN108785322B (zh) * | 2017-04-28 | 2020-11-27 | 南京葆赫生物技术有限公司 | 黑骨藤c21甾类在制备ido抑制剂中的用途 |
CN108785317B (zh) * | 2017-04-28 | 2020-12-01 | 苏州凯祥生物科技有限公司 | 香加皮c21甾类化合物在制备ido抑制剂中的用途 |
CN107226789B (zh) * | 2017-05-09 | 2019-11-08 | 北京大学 | 氨基二硫代甲酸酯类化合物、其制备方法以及在制备抗肿瘤药物中的用途 |
EP3638687A1 (fr) | 2017-06-15 | 2020-04-22 | Indi Molecular, Inc. | Agents de capture spécifiques d'il-17f et il-17a, compositions et procédés d'utilisation et de production |
US11414460B2 (en) | 2019-07-19 | 2022-08-16 | Institute For Systems Biology | KRAS-specific capture agents, compositions, and methods of making and using |
CN111153850B (zh) * | 2020-01-17 | 2021-08-13 | 中国药科大学 | 吲哚类化合物、其制备方法和药物组合物与用途 |
CN111518037B (zh) * | 2020-05-31 | 2021-04-23 | 湖北工业大学 | [2-(5′-氟尿嘧啶)乙酸-乙基苯基二硫代氨基甲酸]酐及在制备抗癌药物中的应用 |
WO2022098743A1 (fr) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imagerie et procédés thérapeutiques ciblant le récepteur 1 de folate (folr1) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU507567A1 (ru) * | 1973-02-02 | 1976-03-25 | Стерлитамакский Опытно-Промышленный Завод По Производству Изопренового Каучука | Способ получени замещенных дитиокарбаматов |
WO2004093871A1 (fr) * | 2003-03-27 | 2004-11-04 | Lankenau Institute For Medical Research | Procedes de traitement du cancer |
-
2006
- 2006-10-27 EP EP06844228A patent/EP1940787A4/fr not_active Withdrawn
- 2006-10-27 WO PCT/US2006/042137 patent/WO2007050963A1/fr active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU507567A1 (ru) * | 1973-02-02 | 1976-03-25 | Стерлитамакский Опытно-Промышленный Завод По Производству Изопренового Каучука | Способ получени замещенных дитиокарбаматов |
WO2004093871A1 (fr) * | 2003-03-27 | 2004-11-04 | Lankenau Institute For Medical Research | Procedes de traitement du cancer |
Non-Patent Citations (10)
Title |
---|
A. S. FISYUK AND B. V+ UNKOVSKII: "SYNTHESIS OF 6-HYDROXYTETRAHYDRO-1,3-THIAZINE-2-THIONES AND METHYL ESTERS OF 3-OXOALKYLDITHIOCARBAMIC ACIDS FROM 1,3-ISOTHIOCYANATO KETONES", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 27, 1991, pages 339 - 341, XP002526364 * |
A. S. FISYUK, E. A. RYZHOVA, AND B. V. UNKOVSKII: "INTERACTION OF METHYL N-(3-OXOALKYL)CARBAMATES, S-METHYL -CARBAMATES, AND -DITHIOCARBAMATES WITH SODIUM BOROHYDRIDE. SYNTHESIS OF TETRAHYDRO- 1,3-OXAZIN-2-ONES AND -THIONES", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 37, 2001, pages 597 - 609, XP002526363 * |
BERNABE M ET AL: "Dérivés du cyclopropane. V. Préparation d'acides amino-1 aryl-2 cyclopropanecarboxyliques et résultats préliminaires de leur interaction ave la dopadécarboxylase", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 14, 1 January 1979 (1979-01-01), pages 33 - 45, XP009116425, ISSN: 0223-5234 * |
BRAUN J V: "Mittheilungen über Dithiourethane", CHEMISCHE BERICHTE, VERLAG CHEMIE GMBH. WEINHEIM, DE, vol. 35, no. 3, 1 October 1902 (1902-10-01), pages 3368, XP009116291, ISSN: 0009-2940 * |
MARTIN ONSLOW FORSTER ET AL: "Studies in the Comphane Series. Part XXIV. Camphoryldithiocarbamic Acid and Camphorylthiocarbimide", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY, LETCHWORTH., GB, vol. 91, 1 January 1907 (1907-01-01), pages 1877 - 1890, XP009116317, ISSN: 0368-1769 * |
MOHANTA P K ET AL: "1-(Methyldithiocarbonyl)imidazole: a Useful Thiocarbonyl Transfer Reagent for Synthesis of Substituted Thioureas", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 56, no. 4, 1 January 2000 (2000-01-01), pages 629 - 637, XP004186122, ISSN: 0040-4020 * |
MONTANARI L ET AL: "Sull'attività antifungina di diesteri del 2-mercapto benzenmetantiolo", FARMACO, EDIZIONE SCIENTIFICA, SOCIETA CHIMICA ITALIANA, PAVIA, vol. 37, 1 January 1982 (1982-01-01), pages 759 - 763, XP009116424, ISSN: 0430-0920 * |
R. E. ORTH AND J. W. JONES: "Preparation of some 1-substituted 1,2,3,4-tetrazole-5-thiones", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 51, 1962, pages 862 - 864, XP002526362 * |
SALVATORE R N ET AL: "Mild and efficient synthesis of thiocarbonates and thiocarbamates via a three-component coupling utilizing Cs2CO3 and TBAI", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 42, no. 11, 11 March 2001 (2001-03-11), pages 2055 - 2058, XP004229200, ISSN: 0040-4039 * |
See also references of WO2007050963A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007050963A1 (fr) | 2007-05-03 |
EP1940787A1 (fr) | 2008-07-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20080425 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: PRENDERGAST, GEORGE, C. Inventor name: DUHADAWAY, JAMES, B. Inventor name: MULLER, ALEXANDER, J. Inventor name: MALACHOWSKI, WILLIAM, P. |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07D 401/12 20060101ALI20090520BHEP Ipc: C07D 417/06 20060101ALI20090520BHEP Ipc: A61K 31/27 20060101ALI20090520BHEP Ipc: A61P 35/00 20060101ALI20090520BHEP Ipc: A61P 31/12 20060101ALI20090520BHEP Ipc: C07C 333/20 20060101ALI20090520BHEP Ipc: C07C 333/22 20060101ALI20090520BHEP Ipc: C07D 209/14 20060101AFI20090520BHEP Ipc: C07C 327/48 20060101ALI20090520BHEP |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20090602 |
|
17Q | First examination report despatched |
Effective date: 20091210 |
|
DAX | Request for extension of the european patent (deleted) | ||
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20120503 |