EP1939178A4 - Verfahren zur herstellung von 1-benzyl-4-[(5,6-dimethoxy-1indanon)-2-yl]methylpiperidin oder des hydrochlorids davon - Google Patents
Verfahren zur herstellung von 1-benzyl-4-[(5,6-dimethoxy-1indanon)-2-yl]methylpiperidin oder des hydrochlorids davonInfo
- Publication number
- EP1939178A4 EP1939178A4 EP06811319A EP06811319A EP1939178A4 EP 1939178 A4 EP1939178 A4 EP 1939178A4 EP 06811319 A EP06811319 A EP 06811319A EP 06811319 A EP06811319 A EP 06811319A EP 1939178 A4 EP1939178 A4 EP 1939178A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- 1indanon
- methylpiperidine
- dimethoxy
- hydrochloride
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J21/00—Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium
- B01J21/02—Boron or aluminium; Oxides or hydroxides thereof
- B01J21/04—Alumina
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
- B01J23/44—Palladium
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005299526 | 2005-10-14 | ||
US73084405P | 2005-10-28 | 2005-10-28 | |
PCT/JP2006/319981 WO2007043440A1 (ja) | 2005-10-14 | 2006-10-05 | 1-ベンジル-4-[(5,6-ジメトキシ-1-インダノン)-2-イル]メチルピペリジンまたはその塩酸塩の製造法 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1939178A1 EP1939178A1 (de) | 2008-07-02 |
EP1939178A4 true EP1939178A4 (de) | 2009-06-17 |
EP1939178B1 EP1939178B1 (de) | 2010-11-24 |
Family
ID=39399266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06811319A Active EP1939178B1 (de) | 2005-10-14 | 2006-10-05 | Verfahren zur herstellung von 1-benzyl-4-[(5,6-dimethoxy-1indanon)-2-yl]methylpiperidin oder des hydrochlorids davon |
Country Status (7)
Country | Link |
---|---|
US (1) | US7332606B2 (de) |
EP (1) | EP1939178B1 (de) |
KR (1) | KR20080046708A (de) |
AU (1) | AU2006300492B2 (de) |
CA (1) | CA2624805A1 (de) |
IL (1) | IL189986A (de) |
WO (1) | WO2007043440A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100534982C (zh) * | 2004-04-28 | 2009-09-02 | 卫材R&D管理有限公司 | 生产1-苄基-4-[(5,6-二甲氧基-2,3-二氢-1-茚酮)-2-基]甲基哌啶及其盐酸盐的方法 |
WO2007108011A2 (en) * | 2006-03-20 | 2007-09-27 | Ind-Swift Laboratories Limited | Process for the preparation of highly pure donepezil |
NZ588252A (en) * | 2008-03-25 | 2012-08-31 | Cipla Ltd | Process for the preparation of donepezil hydrochloride |
WO2011051957A2 (en) * | 2009-10-30 | 2011-05-05 | Neuland Laboratories Ltd. | A process for the preparation of donepezil hydrochloride |
US8552195B2 (en) * | 2011-08-05 | 2013-10-08 | Taiwan Biotech Co., Ltd. | Method for making donepezil |
EP2557077B1 (de) | 2011-08-08 | 2013-10-16 | Taiwan Biotech Co., Ltd. | Verfahren zur Herstellung von Donepezil |
JP2013040150A (ja) * | 2011-08-19 | 2013-02-28 | Taiwan Biotech Co Ltd | ドネペジルの製造方法 |
WO2015173374A1 (en) | 2014-05-16 | 2015-11-19 | Solvay Specialty Polymers Italy S.P.A. | Aromatic compounds bearing hydroxyl-substituted (per)fluoropolyether chains |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5100901A (en) * | 1987-06-22 | 1992-03-31 | Eisai Co., Ltd. | Cyclic amine compounds and pharmaceutical use |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2965675B2 (ja) | 1990-11-21 | 1999-10-18 | エーザイ株式会社 | (―)―1―ベンジル―4―〔(5,6―ジメトキシ―1―インダノン)―2―イル〕メチルピペリジンの製造方法 |
JP3032110B2 (ja) * | 1994-03-17 | 2000-04-10 | 高砂香料工業株式会社 | 光学活性なジアミノヘキサノン誘導体の製造方法 |
ATE241358T1 (de) * | 1997-03-03 | 2003-06-15 | Eisai Co Ltd | Verwendung von cholinesterasehemmer zur behandlung von konzentrationsstörungen |
JP3992806B2 (ja) | 1997-12-12 | 2007-10-17 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ドネペジル中間体の製造法 |
JP4595158B2 (ja) * | 2000-04-21 | 2010-12-08 | 三菱瓦斯化学株式会社 | 担持触媒及びその製造方法 |
US6953856B2 (en) * | 2003-02-12 | 2005-10-11 | Usv, Limited | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) |
CN100534982C (zh) * | 2004-04-28 | 2009-09-02 | 卫材R&D管理有限公司 | 生产1-苄基-4-[(5,6-二甲氧基-2,3-二氢-1-茚酮)-2-基]甲基哌啶及其盐酸盐的方法 |
-
2006
- 2006-10-05 KR KR1020087008668A patent/KR20080046708A/ko not_active Application Discontinuation
- 2006-10-05 EP EP06811319A patent/EP1939178B1/de active Active
- 2006-10-05 WO PCT/JP2006/319981 patent/WO2007043440A1/ja active Application Filing
- 2006-10-05 CA CA002624805A patent/CA2624805A1/en not_active Abandoned
- 2006-10-05 AU AU2006300492A patent/AU2006300492B2/en not_active Ceased
- 2006-10-12 US US11/546,444 patent/US7332606B2/en not_active Expired - Fee Related
-
2008
- 2008-03-06 IL IL189986A patent/IL189986A/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5100901A (en) * | 1987-06-22 | 1992-03-31 | Eisai Co., Ltd. | Cyclic amine compounds and pharmaceutical use |
Also Published As
Publication number | Publication date |
---|---|
AU2006300492A8 (en) | 2008-05-08 |
AU2006300492B2 (en) | 2011-08-25 |
WO2007043440A1 (ja) | 2007-04-19 |
EP1939178A1 (de) | 2008-07-02 |
CA2624805A1 (en) | 2007-04-19 |
AU2006300492A1 (en) | 2007-04-19 |
IL189986A0 (en) | 2008-08-07 |
US7332606B2 (en) | 2008-02-19 |
US20070088055A1 (en) | 2007-04-19 |
KR20080046708A (ko) | 2008-05-27 |
EP1939178B1 (de) | 2010-11-24 |
IL189986A (en) | 2011-09-27 |
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