EP1937215A2 - Pharmazeutische zusammensetzung mit einem eisen-chelatbildner - Google Patents
Pharmazeutische zusammensetzung mit einem eisen-chelatbildnerInfo
- Publication number
- EP1937215A2 EP1937215A2 EP06793171A EP06793171A EP1937215A2 EP 1937215 A2 EP1937215 A2 EP 1937215A2 EP 06793171 A EP06793171 A EP 06793171A EP 06793171 A EP06793171 A EP 06793171A EP 1937215 A2 EP1937215 A2 EP 1937215A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- composition
- active compound
- particles
- sustained release
- phospholipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- Desferrioxamine is used in the treatment of chronic iron overload, such as in transfusional haemosiderosis, thalassaemia major, sideroblastic anaemia, autoimmune haemolytic anaemia, and other chronic anaemias, idiopathic (primary) haemochromatosis in patients in whom concomitant disorders preclude phlebotomy, iron overload associated with porphyria cutanea tarda in patients unable to tolerate phlebotomy.
- desferrioxamine is indicated for treating acute iron poisoning, chronic aluminium overload in patients with end-stage renal failure with aluminium-related bone disease, dialysis encephalopathy or aluminium-related anaemia.
- microparticle compositions of desferrioxamine were made from polylactide-co-glycolide, a hydrophobic biodegradable polymer.
- the drug load capacity of the described microparticles is too low to accomodate a dose of the active compound which would be effective over a period of at least several days.
- polylactide-co-glycolide is known to degrade into acidic reaction products that may render the microclimate within the microparticles substantially acidic, which may lead to the degradation of the acid-labile desferrioxamine.
- an active compound is a chemical or biological substance or mixture of substances which is useful for the diagnosis, prevention or treatment of diseases, symptoms, and other conditions of the body, or for influencing a body function.
- the composition of the invention comprises at least one, and optionally two or more of such active compounds.
- Other expressions which may be used as synonyms for active compounds are drugs, drug substances, active ingredients, active agents and the like.
- sustained release form means that the respective fraction of the iron chelator is formulated and/or processed in such as way that it is released slowly after administration.
- the sustained release characteristics may be achieved by generally known formulation methods and techniques, some of which will be described further below.
- the iron chelator which is in sustained release form is released from the composition over a period of at least about 24 hours after administration. More preferably, the sustained release dose fraction is released over at least about 48 hours, or over at least about 72 hours. If the composition is intended for the treatment of injured nerves, and if it is intended that a single administration is used to achieve the desired therapeutic effect, it is preferred that the iron chelator is released over at least about 4 days, or at least about 5 days or even one week, depending on variable factors such as the size of the lesion and the number of injection sites per lesion. In further embodiments, the release profile is adapted to provide release over at least about 2 weeks, 3 weeks, or even 4 weeks. Without wishing to be bound by theory, it is believed that the sustained release of the iron chelator may or should be adapted to achieve a sufficient delay of scar formation that the regeneration and growth of the nervous tissue at the lesion is not inhibited.
- the preferred duration of drug release refers to the release profile as measured in vitro by an appropriate method and at 37 0 C, using an appropriate medium such as buffer or water for injection.
- the following method may be used to determine the in vitro release from a composition comprising sustained release particles:
- composition is further formulated as a viscoelastic gel, which means that the viscosity is so high that the material behaves like an elastic solid if only low shear forces are exerted, and like a viscous fluid when the shear force exceeds a threshold which is defined as the yield point.
- a gel is a semisolid system with a finite, usually rather small, yield stress.
- the composition if designed to comprise lipid particles or liposomes as sustained release particles, is prepared by combining one or more particle-forming lipids, the iron chelator, and water, optionally in the presence of further active and/or inactive ingredients to form an aqueous dispersion.
- the dispersion may be homogenised, using a suitable homogenising tool, such as an Ultraturrax ® or a high-pressure homogeniser.
- the homogenisation is preferably carried out at elevated temperature, such as at a temperature which is above the phase transition temperature range, or above the melting temperature range, of the lipid(s) selected for particle formation.
- the composition is used for the treatment of spinal cord or peripheral nerve injuries. It has been found that a single administration of the composition (per lesion) may be sufficient to provide the desired effect of scar inhibition for a period of time that is long enough to allow for nerve growth and/or regeneration. For large lesions, it may be useful to select more than one site of injection to better cover the whole lesion, which is still considered as only one administration according to the present invention. The long-lasting effectiveness of the composition is particularly beneficial in that, typically, no repeated administrations are needed.
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06793171A EP1937215A2 (de) | 2005-09-02 | 2006-09-04 | Pharmazeutische zusammensetzung mit einem eisen-chelatbildner |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71334705P | 2005-09-02 | 2005-09-02 | |
| EP05108071 | 2005-09-02 | ||
| EP06793171A EP1937215A2 (de) | 2005-09-02 | 2006-09-04 | Pharmazeutische zusammensetzung mit einem eisen-chelatbildner |
| PCT/EP2006/065952 WO2007026028A2 (en) | 2005-09-02 | 2006-09-04 | Pharmaceutical composition comprising an iron chelator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1937215A2 true EP1937215A2 (de) | 2008-07-02 |
Family
ID=36305265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP06793171A Withdrawn EP1937215A2 (de) | 2005-09-02 | 2006-09-04 | Pharmazeutische zusammensetzung mit einem eisen-chelatbildner |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1937215A2 (de) |
| JP (1) | JP2009507006A (de) |
| KR (1) | KR20080044845A (de) |
| CN (1) | CN101252913A (de) |
| AU (1) | AU2006286445A1 (de) |
| BR (1) | BRPI0615349A2 (de) |
| CA (1) | CA2620685A1 (de) |
| WO (1) | WO2007026028A2 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2000134A1 (de) * | 2007-06-06 | 2008-12-10 | Neuraxo Biopharmaceuticals GmbH | Verwendung einer Substanz zur Behandlung von Verletzungen des peripheren Nervensystems |
| US10220009B2 (en) | 2012-08-30 | 2019-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | HIF-1 modulator paint formulation and uses thereof |
| US10004759B2 (en) | 2014-08-04 | 2018-06-26 | Zoneone Pharma, Inc. | Remote loading of sparingly water-soluble drugs into lipid vesicles |
| WO2016025611A2 (en) * | 2014-08-13 | 2016-02-18 | Zoneone Pharma, Inc. | Pharmaceutical formulations of chelating agents as a metal removal treatment system |
| US11033630B2 (en) * | 2016-02-11 | 2021-06-15 | Mordechai Chevion | Method and pharmaceutical composition for treatment of neurodegeneration |
| CN110573155A (zh) * | 2017-02-27 | 2019-12-13 | 阿德莱德大学 | 用于减少粘连的方法和产品 |
| WO2018237163A1 (en) * | 2017-06-23 | 2018-12-27 | Roman Manetsch | 5-AMINOLEVULINATE SYNTHASE INHIBITORS AND METHODS OF USE |
| CN110464717B (zh) * | 2019-09-23 | 2022-02-18 | 张建国 | 一种2,4-二羟基苯甲酸在制备降低血糖的药物的应用 |
| CN114652844B (zh) * | 2022-04-13 | 2023-10-20 | 南京大学 | 一种基于仿生学设计的纳米组装材料的制备方法及应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023087A (en) * | 1986-02-10 | 1991-06-11 | Liposome Technology, Inc. | Efficient method for preparation of prolonged release liposome-based drug delivery system |
| US5043166A (en) * | 1987-01-09 | 1991-08-27 | Hadasit Medical Research, Inc. | Liposome/anthraquinone drug composition and method |
| EP0878480A1 (de) * | 1997-05-14 | 1998-11-18 | H.W. Prof. Dr. Müller | Verfahren zur Förderung der Nerven-Regenerierung |
| IL130324A0 (en) * | 1999-06-07 | 2000-06-01 | Yeda Res & Dev | Pharmaceutical compositions comprising iron chelators for the treatment of neurodegenerative disorders and some novel iron chelators |
| US8029795B2 (en) * | 1999-12-30 | 2011-10-04 | Gwathmey, Inc. | Targeted iron chelator delivery system |
-
2006
- 2006-09-04 AU AU2006286445A patent/AU2006286445A1/en not_active Abandoned
- 2006-09-04 BR BRPI0615349-6A patent/BRPI0615349A2/pt not_active Application Discontinuation
- 2006-09-04 CA CA002620685A patent/CA2620685A1/en not_active Abandoned
- 2006-09-04 JP JP2008528537A patent/JP2009507006A/ja active Pending
- 2006-09-04 EP EP06793171A patent/EP1937215A2/de not_active Withdrawn
- 2006-09-04 KR KR1020087004966A patent/KR20080044845A/ko not_active Application Discontinuation
- 2006-09-04 WO PCT/EP2006/065952 patent/WO2007026028A2/en active Application Filing
- 2006-09-04 CN CNA2006800318484A patent/CN101252913A/zh active Pending
Non-Patent Citations (1)
| Title |
|---|
| See references of WO2007026028A2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080044845A (ko) | 2008-05-21 |
| AU2006286445A1 (en) | 2007-03-08 |
| CA2620685A1 (en) | 2007-03-08 |
| BRPI0615349A2 (pt) | 2011-05-17 |
| CN101252913A (zh) | 2008-08-27 |
| JP2009507006A (ja) | 2009-02-19 |
| WO2007026028A3 (en) | 2007-06-14 |
| WO2007026028A2 (en) | 2007-03-08 |
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