EP1929941B1 - Portable device for the measurement and control of analytes in biological fluids - Google Patents
Portable device for the measurement and control of analytes in biological fluids Download PDFInfo
- Publication number
- EP1929941B1 EP1929941B1 EP07122455A EP07122455A EP1929941B1 EP 1929941 B1 EP1929941 B1 EP 1929941B1 EP 07122455 A EP07122455 A EP 07122455A EP 07122455 A EP07122455 A EP 07122455A EP 1929941 B1 EP1929941 B1 EP 1929941B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- measuring
- cell
- measurement
- enzymatic
- unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000005259 measurement Methods 0.000 title claims description 31
- 239000013060 biological fluid Substances 0.000 title claims description 7
- 230000002255 enzymatic effect Effects 0.000 claims description 19
- 239000000523 sample Substances 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 10
- 238000007920 subcutaneous administration Methods 0.000 claims description 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 9
- 239000008103 glucose Substances 0.000 claims description 9
- 238000005086 pumping Methods 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- 238000012544 monitoring process Methods 0.000 claims description 4
- 238000003780 insertion Methods 0.000 claims description 3
- 230000037431 insertion Effects 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 230000010412 perfusion Effects 0.000 claims description 3
- 230000007175 bidirectional communication Effects 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 230000002572 peristaltic effect Effects 0.000 claims description 2
- 238000012795 verification Methods 0.000 claims description 2
- 238000004873 anchoring Methods 0.000 claims 1
- 238000004458 analytical method Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000011990 functional testing Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920001410 Microfiber Polymers 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
- 238000004422 calculation algorithm Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003658 microfiber Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
- A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
Definitions
- the present invention refers to the field of devices for almost continuous extracellular biological fluid analysis lasting dozens of hours, and in particular the field of portable equipment provided with electrochemical biosensors for the measurement of glucose and other analytes.
- the United States patent US5791344 concerns a portable device for the analysis of biological liquids which uses an electrochemical biosensor.
- This measuring instrument is powered by the mains and by battery only in the event of an emergency and not for operational service; this limit prevents the use thereof on patients who are free to move and in normal life mode.
- the "measuring cell” element described in the United States patent US5791344 which comprises the electrochemical transducer, requires the use of a battery inside the sensor with evident drawbacks in terms of maintenance and endurance.
- the electrochemical transducer described in the United States patent US6171238 must be "wetted" in the manufacturing phase and kept in said state during the storage period, thus making this phase delicate and difficult to maintain efficient.
- the present invention refers to a portable device provided with biosensor for measurement and control of biological fluids such as glucose and other analytes.
- the present invention consists of a device for continuous measurement and control of analytes present in biological fluids which overcomes the drawbacks of the devices belonging to the state of the art by introducing numerous improvements: the possibility of using electrolytic cells with two, three or more electrodes, with polarisation voltage between a few millivolts and 100 millivolts; the possibility of measuring the fluid temperature at the outlet of said electrolytic cell in high resolution mode for diagnostic purposes, hence it can also be used for performing very accurate thermal compensation of the electrochemical measurement; the possibility of performing optimised correction of both the systematic and random errors in the measurement performed; the possibility of calibrating the sensors used more accurately and efficiently and, lastly, the possibility of performing the measurement with much lower polarisation voltages at the electrodes than the equipment in the state of the art with consequent benefits in terms of reduced wear of the electrodes used and reduced susceptibility to electrochemical interferences in the measuring phase.
- Fig. 1 shows in detail the structure of the equipment according to the present invention. There are three separate modules:
- Said measuring cell 20 comprises in turn:
- Said measuring unit 21 preferably comprises:
- Said pumping means comprise a pump for example of the mechanical type - syringe or peristaltic - or a diaphragm or piezoelectric pump.
- Said air bubble separator 33 will preferably be provided with appropriate means for filtering and separating any micro air bubbles that could obstruct conveying of the solution contained in said first tank 23 into the subcutaneous area of the patient.
- said enzymatic cell 29 comprises in detail:
- the device subject of the present invention can comprise enzymatic biosensors with three or two electrodes, thus offering extreme flexibility of use.
- the measuring cell 20 is connected to the measuring and recording unit 21 by means of an electro-fluidic wiring 25, 26, 36, 37 which connects the electrical terminals of the sensors 29 and 30 to the measuring circuit present in the module 31, and the solution delivery tubes 25 and collection tubes 26 to the tank 23 and to the discharge tank respectively.
- a functional test is performed on the enzymatic sensor, which can be activated by means of the remote control unit 22, after inserting the power supply battery 34 into the measurement and recording unit 21.
- This Sensor Check procedure consists in pumping, with an appropriate flow, the perfusion solution through the element 32 containing a sample of glucose at known concentration, and in reading the consequent response of the enzymatic sensor acquiring the current signal for a period of a few minutes.
- An appropriate calculation algorithm determines whether the response falls within the predefined acceptance criteria. If the response is outside the above-mentioned criteria, the disposable measuring cell is replaced and the functional test is repeated. If the Sensor Check is positive, the measuring cell 20 is applied to the patient's skin after inserting the probe 28 under the skin by means of an appropriate guide needle, and the measurement and recording unit 21 is strapped to the patient by means of an appropriate belt. At this point the monitoring is initiated by means of an appropriate command from the remote unit 22, which starts the pump, the measurement and recording of the data for dozens of hours. Via the remote unit 22 provided with appropriate display it is possible to connect at any time via radio to the recorder and display the measurements in real time in both numerical and graphic form.
- the entire profile recorded up to that moment by the enzymatic sensor and by the temperature sensor can be displayed.
- the continuous temperature measurement is used to compensate the enzymatic sensor current and maximise accuracy of the measurement. This is accurate enough to continuously represent the actual body temperature of the patient with evident diagnostic value in addition to measurement of the glucose or other analyte detected by the enzymatic sensor.
- Said measurement cell 20 is provided with a device 33 for separation of any air bubbles present in the fluidic circuit which could affect measurement of the enzymatic sensor.
- Said device 33 for separation of the air bubbles is produced by means of a chamber with two special membranes, one of which permits, at the working pressures, passage of the liquid along the fluidic line but separation of the bubbles, while the other permits outflow of the air accumulated in the chamber but not that of the perfusion liquid.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI200731246T SI1929941T1 (sl) | 2006-12-07 | 2007-12-06 | Prenosna naprava za merjenje in kontrolo analitov v bioloĺ kih tekoäśinah |
PL07122455T PL1929941T3 (pl) | 2006-12-07 | 2007-12-06 | Przenośne urządzenie do pomiaru i kontroli analitów w płynach biologicznych |
CY20131100550T CY1114234T1 (el) | 2006-12-07 | 2013-07-03 | Φορητη συσκευη για τη μετρηση και τον ελεγχο των αναλυτων στα βιολογικα υγρα |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000310A ITFI20060310A1 (it) | 2006-12-07 | 2006-12-07 | Dispositivo portatile per la misura ed il controllo di analiti in fluidi biologici. |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1929941A1 EP1929941A1 (en) | 2008-06-11 |
EP1929941B1 true EP1929941B1 (en) | 2013-04-03 |
Family
ID=39221371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07122455A Active EP1929941B1 (en) | 2006-12-07 | 2007-12-06 | Portable device for the measurement and control of analytes in biological fluids |
Country Status (12)
Country | Link |
---|---|
US (1) | US8273228B2 (ru) |
EP (1) | EP1929941B1 (ru) |
CY (1) | CY1114234T1 (ru) |
DK (1) | DK1929941T3 (ru) |
ES (1) | ES2414979T3 (ru) |
HR (1) | HRP20130500T1 (ru) |
IT (1) | ITFI20060310A1 (ru) |
PL (1) | PL1929941T3 (ru) |
PT (1) | PT1929941E (ru) |
RS (1) | RS52794B (ru) |
RU (1) | RU2470300C2 (ru) |
SI (1) | SI1929941T1 (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2755245C1 (ru) * | 2017-12-21 | 2021-09-14 | Ф.Хоффманн-Ля Рош Аг | Медицинская система и способ ее изготовления |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8996089B2 (en) * | 2009-06-30 | 2015-03-31 | Arkray, Inc. | Continuous analysis device and sample component control system |
EP3180065A4 (en) | 2014-07-24 | 2018-04-11 | Thomas Jefferson University | Long-term implantable monitoring system & methods of use |
US20190025283A1 (en) | 2015-09-07 | 2019-01-24 | Ibrahim ISILDAK | A urea, phosphate and ph measuring device |
EP4233720A3 (en) | 2016-02-05 | 2023-09-06 | Roche Diabetes Care GmbH | Medical device for detecting at least one analyte in a body fluid |
SI3954288T1 (sl) | 2016-02-05 | 2023-07-31 | F. Hoffmann - La Roche Ag | Medicinski pripomoček za odkrivanje vsaj enega analita v telesni tekočini |
EP3361402A1 (en) * | 2017-02-14 | 2018-08-15 | Roche Diabetes Care GmbH | A computer-implemented method and a portable device for analyzing glucose monitoring data indicative of a glucose level in a bodily fluid, and a computer program product |
EP3600493A4 (en) | 2017-03-31 | 2020-08-19 | Capillary Biomedical, Inc. | HELICOIDAL INSERTION INFUSION DEVICE |
CN117269284B (zh) * | 2023-11-22 | 2024-02-27 | 中国人民解放军军事科学院军事医学研究院 | 携氧-释氧能力相对评价装置 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE442640B (sv) * | 1977-12-16 | 1986-01-20 | Gambro Lundia Ab | Sett och anordning for att meta koncentrationen av en forening i ett flytande medium |
US4832034A (en) * | 1987-04-09 | 1989-05-23 | Pizziconi Vincent B | Method and apparatus for withdrawing, collecting and biosensing chemical constituents from complex fluids |
DE4130742A1 (de) * | 1991-09-16 | 1993-03-18 | Inst Diabetestechnologie Gemei | Verfahren und anordnung zur bestimmung der konzentration von inhaltsstoffen in koerperfluessigkeiten |
DE4405149C2 (de) | 1993-02-25 | 1998-11-26 | Daimler Benz Aerospace Ag | Anordnung zum Bestimmen der Konzentration von Inhaltsstoffen in Körperflüssigkeiten |
US5791344A (en) * | 1993-11-19 | 1998-08-11 | Alfred E. Mann Foundation For Scientific Research | Patient monitoring system |
DE29511566U1 (de) | 1995-07-10 | 1995-11-30 | Bst Bio Sensor Tech Gmbh | Mobiles Handgerät mit Biosensor |
US6267926B1 (en) * | 1998-10-08 | 2001-07-31 | Celgard Inc. | Device for removing entrained gases from liquids |
US6360888B1 (en) * | 1999-02-25 | 2002-03-26 | Minimed Inc. | Glucose sensor package system |
US6612111B1 (en) * | 2000-03-27 | 2003-09-02 | Lifescan, Inc. | Method and device for sampling and analyzing interstitial fluid and whole blood samples |
IT1314759B1 (it) | 2000-05-08 | 2003-01-03 | Menarini Farma Ind | Strumentazione per la misura ed il controllo del contenuto di glucosiolattato o altri metaboliti in fluidi biologici |
US7774145B2 (en) * | 2003-08-01 | 2010-08-10 | Dexcom, Inc. | Transcutaneous analyte sensor |
EP3175780A1 (en) * | 2003-12-18 | 2017-06-07 | Metronom Health, Inc. | Implantable biosensor and methods of use thereof |
WO2006105146A2 (en) * | 2005-03-29 | 2006-10-05 | Arkal Medical, Inc. | Devices, systems, methods and tools for continuous glucose monitoring |
-
2006
- 2006-12-07 IT IT000310A patent/ITFI20060310A1/it unknown
-
2007
- 2007-12-06 RS RS20130236A patent/RS52794B/en unknown
- 2007-12-06 PT PT71224554T patent/PT1929941E/pt unknown
- 2007-12-06 PL PL07122455T patent/PL1929941T3/pl unknown
- 2007-12-06 EP EP07122455A patent/EP1929941B1/en active Active
- 2007-12-06 DK DK07122455.4T patent/DK1929941T3/da active
- 2007-12-06 US US11/999,916 patent/US8273228B2/en active Active
- 2007-12-06 ES ES07122455T patent/ES2414979T3/es active Active
- 2007-12-06 SI SI200731246T patent/SI1929941T1/sl unknown
- 2007-12-06 RU RU2007145352/15A patent/RU2470300C2/ru active
-
2013
- 2013-06-06 HR HRP20130500TT patent/HRP20130500T1/hr unknown
- 2013-07-03 CY CY20131100550T patent/CY1114234T1/el unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2755245C1 (ru) * | 2017-12-21 | 2021-09-14 | Ф.Хоффманн-Ля Рош Аг | Медицинская система и способ ее изготовления |
Also Published As
Publication number | Publication date |
---|---|
HRP20130500T1 (en) | 2013-07-31 |
DK1929941T3 (da) | 2013-06-10 |
PT1929941E (pt) | 2013-07-10 |
RU2470300C2 (ru) | 2012-12-20 |
ITFI20060310A1 (it) | 2008-06-08 |
US8273228B2 (en) | 2012-09-25 |
US20080149478A1 (en) | 2008-06-26 |
PL1929941T3 (pl) | 2013-09-30 |
RS52794B (en) | 2013-10-31 |
ES2414979T3 (es) | 2013-07-23 |
SI1929941T1 (sl) | 2013-07-31 |
RU2007145352A (ru) | 2009-06-20 |
CY1114234T1 (el) | 2016-08-31 |
EP1929941A1 (en) | 2008-06-11 |
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