EP1926514B1 - Injection device with two-way slip clutch - Google Patents
Injection device with two-way slip clutch Download PDFInfo
- Publication number
- EP1926514B1 EP1926514B1 EP06775147A EP06775147A EP1926514B1 EP 1926514 B1 EP1926514 B1 EP 1926514B1 EP 06775147 A EP06775147 A EP 06775147A EP 06775147 A EP06775147 A EP 06775147A EP 1926514 B1 EP1926514 B1 EP 1926514B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- spring
- clutch
- injection device
- dose
- dosing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2403—Ampoule inserted into the ampoule holder
- A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2485—Ampoule holder connected to rest of syringe
- A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
Definitions
- the invention relates to an injection device for an injectable product, preferably a liquid medicament such as insulin, a growth hormone or an osteoporosis preparation.
- An injection device is known with a housing in which a reservoir for an injectable product with a delivery piston are arranged.
- a piston rod is threadedly engaged with the housing.
- the device further comprises a metering member which is axially movable in threaded engagement with the piston rod relative to the housing and the piston rod, a rotary knob which is rotatable relative to the housing but axially non-movable and which is secured against rotation with the metering member, a coupling member is connected to the piston rod axially secured against rotation and forms a two-way slip clutch with the dosing, and finally a spring member which acts on the coupling member with a resilience and thereby holds in a clutch engagement with the dosing.
- the slip clutch is designed as Drehloiskupplung with two sprockets that are together in a releasable against the force of the spring member latching engagement and thus form the clutch engagement.
- the latching engagement is releasable against the force of the spring member in both directions of rotation, so that by a rotational movement of the dosing in a metering direction, the dose can be increased and reduced by a rotational movement in an opposite correction direction.
- the spring member acts in a double function as a clutch spring, which biases the coupling member into coupling engagement with the dosing member, and as a discharge spring, the spring tension is increased in the setting by increasing the dose and the distribution of the piston causes the propulsion.
- the sprockets In order to prevent accidental slippage of the clutch when setting the dose, it is necessary for the sprockets to be engaged in clutch engagement Withstand spring tension. The amount of force required by the user to increase the dose is correspondingly high.
- the invention relates to an injection device comprising a housing with an injectable product reservoir, a pres # dose adjustment knob, a set dose delivery spreader, a two-way slipper clutch, and a spring member.
- the actuation knob is movable to adjust the dose relative to the housing in a dose-increasing dosage direction and a dose-reducing correction direction.
- the actuating knob is rotatable relative to the housing.
- the dose adjustment knob may also be linearly movable or rotationally movable relative to the housing, or, in yet an alternative embodiment, linearly movable.
- the housing and the dosing button each form a joint member of a jointly formed pivot joint.
- the dosing button can also be movably connected to the housing only via one or more further joint elements and correspondingly a plurality of joints. Conveniently, a linearly movably received in the reservoir conveyor piston form the conveyor member.
- the two-way slip clutch comprises at least one latching element and at least one locking counter-element, the latching in a latching engagement with each other dosing the knob when moving in the metering direction and during movement in the correction direction in discrete detent positions with the housing positively and non-positively.
- the spring member counteracts the movement of the Dosierknopfs in at least one of the two directions, preferably the movement in the metering direction, with an elastic spring force.
- the locking element or the counter-locking element in response to the spring force is shaped so that they oppose in the latching engagement of the movement in the direction favored by the spring force greater resistance than the movement in the other direction.
- the word "or” is used here as well as otherwise in the usual logical sense of "and / or”, as far as no other meaning arises from the context of the respective use of the word.
- the shape of the latching element or the latching counter element is preferably selected so that the slip clutch opposes the movement of the actuating button in the correction direction greater resistance than the movement in the metering direction and the frictional resistance to be overcome for the metering form is lower than that for the dose correction to be overcome frictional resistance.
- the spring member is stretched by the movement of the actuating knob in the at least one direction from locking position to locking position stronger. Due to the inventively formed locking element or locking counter element accidental slippage of the clutch in the other direction, in which the spring member acts, are safer than in the prior art to be prevented, while at the same time due to the shape of the at least one locking element or locking counter-element resistance to the Movement in the at least one direction may be less than in the case of a conventional, with respect to the direction of movement indifferent slip clutch.
- the force required for adjusting the dose can be reduced compared with the prior art and the holding force of the coupling can nevertheless be increased. Likewise, the force required for the adjustment of the dose can be reduced or the holding force of the slip clutch can be increased while maintaining the same holding force.
- the spring member may form a coupling spring, against the spring force, the locking element and locking counter element are moved away from each other both in the movement in the metering direction and during the movement in the correction direction to lock in the next locking position again.
- the spring force can be the same for both directions of movement in each locking position. However, this is more preferable Spring member during the movement in the at least one of the directions of detent position to detent position more tense, so that it opposes the movement in the direction in question a greater spring force than in the other: It may be the movement in the other direction also one, albeit smaller Counteract spring force.
- the spring member counteracts only the movement in the at least one of the two directions of a spring force.
- the spring member does not serve as a clutch spring.
- a clutch spring as a further spring member or a plurality of clutch springs are provided as further spring members, so that the locking element and locking counter-member are movable in both directions of movement against the elasticity of the separate clutch spring or the plurality of separate clutch springs from locking position to locking position.
- the functional relief of the spring member in this regard opens up design freedom in terms of the shape and the installation of the spring member.
- the spring member can be used more easily in another additional function.
- the slip clutch can be optimized by means of at least one separate clutch spring or the plurality of separate clutch springs in terms of their holding power and the effort required to overcome the holding force.
- the spring member is preferably a mechanical spring, but may alternatively be a pneumatic spring.
- the function according to the spring member may in particular be a compression spring or a torsion spring, optionally also a tension spring.
- the delivery member is drivable in the distribution of the dose by means of the spring member.
- the delivery member is driven in the distribution only by the spring member.
- the user must apply at least a part of the force required for driving the conveyor member, and the conveyor member performs the function of a servo spring, which supports the user, so that in the distribution of the user and the spring member for share the force required to drive the conveyor link.
- a preferred example of the second variant is disclosed in German patent application no. 10 2005 043 806.7 which is referenced.
- the locking element and the locking counter-element are movable from locking position to locking position in a Kupplungsdosier therapies and a coupling correction direction.
- the Kupplungsdosier therapies and the coupling correction direction are opposite to each other.
- the actuating knob is connected to a latching element and latching counter element so that the Kupplungsdosierides the metering direction and the coupling correction direction correspond to the correction direction of the actuating knob.
- the one of locking element and locking counter-element is formed or fixed to the actuating button so that it participates in the movement.
- the one of latching element and latching counter element can kinematically with the operating knob but also via one or more intermediate links, i.
- the Kupplungsdosierraum may differ from the metering direction of the operating knob.
- the detent member moves relative to the detent counterpart in the Kupplungsdosierraum when the operating knob is moved in the metering direction, and moves in the coupling correction direction when the operating knob is moved in the direction of correction.
- the slip clutch comprises at least two coupling halves, namely a first coupling half with the at least one locking element and a second coupling half with the at least one locking counter-element.
- the locking element and the counter-locking element are preferably integrally formed on the respective coupling half in one piece, ie integrally connected to the associated coupling half or more preferably formed the same at the original formation. Alternatively, they may also be attached to the respective coupling half.
- the slip clutch is a rotary clutch, wherein one of the coupling halves is rotatable relative to the other at least for setting the dose about a rotation axis.
- the housing forms one of the coupling halves.
- a separately manufactured, but firmly connected to a housing shell part is calculated as belonging to the housing.
- a rotationally secured relative to the rotation axis with the housing, but in another way relative to the housing movable structure, in particular an axially movable structure one of the coupling halves form.
- both Coupling halves relative to the housing to be rotatable about the axis of rotation, wherein, however, one of the coupling halves, at least when setting the dose secured against rotation connected to the housing or optionally coupled via a transmission to the housing.
- the actuating knob moves in the axial direction in adjusting the dose as well as in discharging together with the axially movable structure , as in particular in the German patent application no. 10 2005 043 806.7 is disclosed.
- the relative movement between the coupling halves can basically also be a rotationally free translation movement or a movement composed of translation and rotation.
- the relative movement may be an axial movement parallel to a longitudinal axis of the injection device or a linear movement transverse to the longitudinal axis.
- the housing can form one of the coupling halves, a part immovably connected to the housing or a part which is not movable relative to the housing in the direction of relative mobility and which forms one of the coupling halves or which supports one of the coupling halves.
- the slip clutch comprises exactly two coupling halves, ie it consists in such embodiments of said coupling halves, and the locking element and the locking counter-element engage in the locking engagement with each other.
- the slip clutch comprises the two coupling halves and also a transmission member arranged between the coupling halves. The transmission member is in a latching engagement with a first of the two coupling halves and in a further latching engagement with the second of the coupling halves, preferably it forms a rotary friction coupling with the two coupling halves.
- Such a slip clutch is in the DE 102 37 258 A1 disclosed in this regard.
- the tripartite slip clutch in such alternative embodiments comprises two pairs of at least one latching element and at least one each Detent counter element.
- the first coupling half is movable relative to the second coupling half again in a Kupplungsdosierraum and an opposite Kupplungskorrekturraum, wherein in latching engagement with the transmission member relative to the transmission member in one of these two directions and in locking engagement of the transmission member with the second coupling half relative to this only in common the transmission member is movable in the other direction.
- the at least one latching element or the at least one latching counter-element is or are asymmetrically shaped in preferred embodiments with respect to the two directions in which they are reciprocable relative to each other.
- the asymmetry is preferably such that a greater force must be expended for the movement of the actuating button in the direction of correction than for the movement in the metering direction.
- the resistance to be overcome in the latching engagement of latching element and latching counter element is thus greater in the correction direction than in the metering direction.
- the latching element and locking counter-element which constitute a latching projection and a latching recess, have flanks with respect to the two directions of their relative movement flanks, which are asymmetrical with respect to the two directions by a steeper in one of the two directions edge of the locking element or the counter-locking element is steeper as the flank of the same element pointing in the other direction.
- An adapted, congruent form of locking element and locking counter-element is preferred.
- the locking element and the locking counter-element of the slip clutch namely the locking element and locking counter-element of the mutually contacting coupling halves in one Embodiment and the at least two pairs of locking element and locking counter-element of the two coupling halves and the transmission member in the alternative embodiment, can be placed relentlessly on the coupling halves and the optional transmission member.
- at least one of the coupling halves or the optional transmission member is supported elastically resiliently against a spring force as a whole, so that the friction clutch can be moved in the latching engagement.
- the locking element or locking counter-element is arranged elastically yielding to the respective coupling half or the optional transmission member.
- each locking element or locking counter-element form an elastic snapper by per locking element or locking counter-element
- a clutch spring is provided, from which the associated locking element protrudes or is excluded as a detent recess.
- both the locking element and the locking counter-element can each be formed as an elastic snapper, it is preferred if only one of locking element and locking counter-element is elastically yielding and the other is relentless.
- the clutch spring may in particular be an elastic bending beam, which is either clamped only on one side and protrudes freely from its clamping, preferably in the circumferential direction about the axis of rotation, if the slip clutch is formed as Drehrisonkupplung.
- the clutch spring is formed as both sides clamped bending beam.
- the relevant coupling half can be formed for this purpose, for example, as a sleeve with an internal axis of rotation, at least in a section forming the detent element or detent counter element.
- the sleeve is provided axially adjacent to the bending beam with an opening, next to the bending beam remains as a bridge element. Seen in the circumferential direction can be obtained in this way one behind the other several bending beam with the remaining remaining stiffer sleeve segments.
- the spring member advantageously acts directly or optionally only one or more Intermediate links on a dosing member, for the Adjustment of the dose relative to the housing is movable back and forth.
- the dosing is moved in one of the two directions of its mobility up against a Aus commonlyanschlag.
- it is also movable in the other direction of mobility up to a maximum dose stop.
- the mobility of the dosing member may be a pure translational mobility or a pure rotational mobility, it is preferably a both translational and rotational mobility.
- the dosing member may in particular be a joint element of a screw joint. In the case of a rotatable dosing preferably at least one of said stops is a rotational stop.
- the slip clutch comprises only a single locking element and a single locking counter-element or in embodiments with transfer member only two pairs of only one locking element and a locking counter-element
- each locking engagement several locking elements and a plurality of locking counter-element are provided. It can lock in the respective latching engagement, even a single locking element with a plurality of locking counter-elements, namely from locking position to locking position in each case with the next locking counter-element.
- only a single locking counter-element per latch engagement applies mutatis mutandis, the same.
- FIG. 1 shows an injection device in a side view.
- the injection device is formed as elongated, slender Injetationspen. It comprises a housing with a distal housing section 1 and a proximal housing section, which comprises two housing sections 2 and 3 firmly connected to one another.
- the injection device serves to administer a liquid medicament, for example insulin.
- the medicament is contained in a reservoir, which is exchangeably inserted in the housing section 1.
- the medicament is administrable through an outlet 1a formed at the distal end of the housing portion 1.
- the injection device is substantially rotationally symmetrical with respect to a central longitudinal axis RT.
- the housing sections 1-3 are each formed of opaque plastic material.
- the housing portion 1 has a window 1b which extends to or close to the proximal end of the housing portion 1 and close to the outlet 1a, but is comparatively narrow in the circumferential direction about the axis RT .
- the housing section 2 also has a window 2b, which covers the window 1b in the connected state of the housing sections 1 and 2, so that even in the connection region of the housing sections 1 and 2, the view of the reservoir is free.
- the windows 1b and 2b are the same width in the circumferential direction, but different dimensions in the circumferential direction would be quite conceivable as long as at least the function of the review of the reservoir is fulfilled.
- a further window 4 is formed in the form of a magnifying glass.
- An actuating button 27 forms the proximal end of the injection device.
- the actuating button 27 fulfills the function of a manually operable Dosierknopfs, by the operation of a dose to be administered the drug is selectable or adjustable, and also the function of a trigger button, by the operation of the set dose is aus wellbar.
- the set dose can be read through the window 4 on a running below the window 4 in the setting dose scale.
- the Figures 2 and 3 each show the injection device in a longitudinal section containing the longitudinal axis RT, the FIG. 2 in the whole and the FIG. 3 the proximal portion in an enlarged view.
- the reservoir R is an ampoule made of glass or transparent plastic.
- a piston 10 is received in a direction of advance V on the outlet 1a to axially movable.
- the reservoir R is completely filled, and the piston R proximal closing the reservoir R 10 assumes its most proximal position.
- the housing section 1 basically forms only a reservoir holder. It is fixed to the housing portion 2, but releasably connected for an exchange of the reservoir 1, for example screwed.
- the sections 2 and 3 forming the proximal housing section are likewise firmly connected to one another, preferably by material engagement, and can be functionally regarded as a single housing section 2, 3.
- the housing section 2, 3 supports a dosing and advancing device, by means of which a dose of the medicament which can be distributed per injection can be set and the set dose can be distributed by propulsion of the piston 10.
- the actuation button 27 is coupled to adjust the dose by means of a Dosierkupplung with the metering and propulsion device.
- the dosing and advancing device comprises a plurality of members, which are coupled to each other by means of the dosing and a discharge coupling in the setting of the dose and their landfill in different ways.
- a piston rod 11 forms one of these links. In the distribution, the piston rod 11 presses against the back of the piston 10, so that it moves in the advancing direction V and drug is discharged through the outlet 1 a.
- the piston rod 11 is threadedly engaged with the housing portion 2 for which it is threaded over most of its length.
- the housing section 2 forms the mating thread on a retaining device 2a projecting radially inwardly against the piston rod 11 (FIGS. FIG. 3 ).
- the propulsion movement of the piston rod 11 is a rotational movement about the longitudinal axis RT with superimposed translation in the advancing direction V.
- the thread of Piston rod 11 is not formed circumferentially, but is interrupted at least by an axial flat side or groove. However, the threaded engagement with the holding device 2a and the threaded engagement of the holder of the piston rod 11 does not detract from this.
- the metering and advancing device further comprises a first coupling member 12, a second coupling member 16 and a third coupling member 22.
- the coupling member 12 is connected to the piston rod 11 along the flat side or groove in a guide engagement axially movable, but secured against rotation.
- the coupling member 12 is disposed proximally of the holding device 2a and presses in the advancing direction V against the holding device 2a.
- the coupling member 12 surrounds the piston rod 11.
- the coupling member 12 includes a distal portion that contacts the retainer 2a and a proximal portion that extends to the operating knob 27. Between the two sections, a spring 13 is formed.
- a further spring 14 is formed, which comprises a plurality of projecting in the direction of the holding device 2a spring tongues, which are elastically tensioned.
- the spring tongues of the spring 14 form latching elements which latch with latching counter-elements of the holding device 2a, so that between the coupling member 12 and the holding device 2a and thus the housing portion 2 a Drehloiskupplung is obtained, which prevents the piston rod 11 in vibration relative to the housing Can turn 1-3.
- the transferable in the coupling engagement of the locking elements and locking counterparts of Drehloiskupplung force is not so great that it prevents the required for the discharge of the set dose rotational movement of the piston rod 11 or even hindered to a practically relevant extent.
- the coupling member 12 can axially deflect.
- the coupling member 12 is formed, including the two springs 13 and 14 in one piece of plastic, preferably by injection molding.
- the coupling member 16 is rotatably mounted about the axis RT. It is sleeve-shaped and surrounds the coupling member 12. At the distal end of the coupling member 16 is a spring 17, in the embodiment, an axially short coil spring, formed in one piece. The coupling member 16 is supported with its spring 17 in the distal direction on the coupling member 12 and pushes this against the holding device 2a. At the proximal end of the coupling member 16 engaging elements 20 are formed, which are in the illustrated state of the injection device in a releasable coupling engagement with engagement counter-elements 24 of the coupling member 22.
- the engagement elements 20 and engagement counter-elements 24 may be axially from the coupling member 16 or 22 towards the other protruding teeth forming two intermeshing in the clutch engagement, concentric with the axis RT sprockets with preferably uniform pitch, as in FIG. 4 is shown by way of example.
- the coupling members 16 and 22 form the Dosierkupplung and are connected to each other in the clutch engagement against rotation.
- FIG. 4 shows the coupling halves of Dosierkupplung, namely the coupling members 16 and 22, in clutch engagement and detached from the overall context, so that their functional elements 17-20 on the one hand and 23-25 on the other hand clearly visible.
- the coupling member 22 is also sleeve-shaped and has at its proximal end on a radially outwardly projecting flange. On the outer periphery of the flange engaging elements 25 are formed, which connect the coupling member 22 secured against rotation with the actuating knob 27.
- the coupling member 22 is supported via a spring 23 axially on the actuating knob 27 from.
- the spring 23 is an integral part of the coupling member 22 by the coupling member 22 is formed in one piece, including the spring 23 made of plastic.
- the spring 23 is similar to the spring 14 of a plurality of curved around the axis RT and axially projecting spring tongues.
- the coupling member 22 is in threaded engagement with a stop member 26.
- the coupling member 22 is at its outer periphery in front of the flange with a thread 22a provided ( Fig. 4 ).
- the housing portion 3 forms the thread 22a radially outwardly opposite an axial guide 7 for the stop member 26, so that the stop member 26 is axially moved during a rotational movement of the coupling member 22 in threaded engagement.
- the axial displacement of the stop member 26 corresponds to the amount of drug, the maximum, ie at full reservoir R, is available and administered in several injections.
- the stop member 26 moves guided by the axial guide 7 along the external thread 22a of the coupling member 22 in the axial direction, in the exemplary embodiment in the advancing direction V. If the stop member 26 in this direction of movement at an axial stop formed by an inner sleeve 6 has arrived, this means that the reservoir R has been completely emptied.
- the inner sleeve 6 forms the axial guide 7 and is not axially movable relative to the housing section 3, in the exemplary embodiment it is formed on the housing section 3 via a radial connecting web, ie it is part of the housing section 3.
- the metering and advancing device further comprises a metering and display member 30 which is in threaded engagement with the housing portion 3.
- a metering and display member 30 which is in threaded engagement with the housing portion 3.
- the housing section 2 is smooth in the area of contact with the metering and display member 30.
- the thread 3a is formed directly on the shell inner surface of the circular cylindrical shell of the housing section 2, 3.
- the dosing and indicating member 30 is essentially a simple circular cylindrical sleeve with a correspondingly shaped external thread 30a.
- the threads 3a and 30a have a significantly greater thread pitch than the threads of the piston rod 11 and the holding device 2a. The thread pitch is so great that self-locking in threaded engagement is prevented and the metering and indicating member 30 rotates under a pure axial force in threaded engagement relative to the housing portion 2, 3 and is moved axially.
- the metering and display member 30 is axially movable, but non-rotatably coupled to the coupling member 16.
- the dosing and indicating member 30 and the coupling member 16 are directly in a corresponding guide engagement with each other.
- the coupling member 16 forms for this purpose an axial guide 18 at its outer periphery.
- On the inner surface of the dosing and display member 30 is a Engaging member 31 protruding shaped, with which the metering and indicator member 30 in guiding engagement with the coupling member 16, ie with its guide 18, is.
- the guide 18 extends over most of the length of the coupling member 16 and is traversed by the metering and indicating member 30 when setting the maximum dose over most of its length.
- the guide 18 is formed by axial grooves in the outer shell surface of the coupling member 16 ( Fig. 4 ). At their distal ends, the grooves each form a stop 19 for the engagement element 31.
- the metering and advancing device comprises a spring member 32, which acts on the metering and indicating member 30 in the distal direction with a force.
- the spring member 32 of the embodiment is a coil spring and acts as a compression spring.
- the spring member 32 is supported in the proximal direction on the housing portion 3 from.
- the spring member 32 is supported in the distal direction on an annular sliding disk 33, which is inserted between the coupling member 16 and the metering and display member 30 and in turn is supported on the engagement member 31.
- the spring member 32 is largely decoupled from rotational movements of the metering and display member 30.
- the metering and indicator member 30 is movable relative to the piston 10 and the piston rod 11 and, moreover, to the coupling members 12, 16 and 22 between axial end positions back and forth.
- the two end positions are a zero dose position and a maximum dose position.
- the two end positions are each determined by a stop.
- the stop for the zero-dose position forms a shoulder 2c at the distal end of the housing portion 2 as an axial stop.
- the stop for the maximum dose position forms the housing section 3.
- a distal portion of the metering and indicator member 30 overlaps the reservoir R in the advancing direction V to beyond the piston 10 when the piston 10 as in the Figures 2 and 3 represented occupied in the reservoir R rearmost position.
- the piston 10 occupies this position when the reservoir R is completely filled.
- the thread 30a extends to the distal end or at least to near the distal end of the dosing and indicating member 30, so that the thread 30a axially overlaps the reservoir R and the piston 10 when the dosing and indicating member 30 Zero dose position.
- the thread 30a terminates in front of the distal end of the metering member 30 and forms, together with the thread 3a of the housing portion 3, a rotation stop which determines the maximum dose position of the metering and indicating member.
- the thread 30a could alternatively also leak at the distal end of the dosing and indicating member 30; the maximum dose position determining abutment would be otherwise in such a modification.
- the metering and display member 30 is not circumferentially fully cylindrical at its distal end, but only partially cylindrical, in order to release the view of the piston despite the axial overlap, even if the metering and display member 30 as preferred not from a transparent plastic material, but from an opaque or at most opaque plastic material or other material is formed.
- the distal edge of the dosing and indicating member 30 spirals around the axis RT so that the dosing and indicating member 30 as in FIGS Figures 2 and 3 recognizable with its distal end in a peripheral region axially even beyond the piston 10 protrudes and in another peripheral region, which is in the zero dose position with the window in register, behind the piston 10 protrudes, so that the piston 10 through the windows 1b and 2b can be observed.
- the metering and indicator member 30 may extend all the way to the same axial height except for, for example, an aperture, and so protrude everywhere beyond the piston 10 in the advancing direction V, except for the perforated portion, the aperture being in the zero-dose mode. Position in overlap with the window 2b would be.
- the shoulder 2c of the housing portion 2 is also wound around the axis RT following the spiral course of the distal edge of the metering and indicating member 30. The winding course of the shoulder 2c can also be FIG. 1 seen.
- the housing section 2 comprises an outer sleeve which, together with the housing section 3, surrounds the metering and advancing device, and an inner sleeve which is connected at its distal end to the outer sleeve by a web forming the shoulder 2c and at its proximal end Holding device 2a protrudes radially inwardly.
- An annular gap remains between the outer and the inner sleeve, into which the metering and indicating member 30 protrudes in the zero-dose position over a greater part of its length, the larger part being in the region of the longest segment of the dosing. and indicator member 30 is about 50% of the total length of metering and indicating member 30.
- the dosing and indicating member 30 carries a dose scale which spirals on the outer circumference of the dosing and indicating member 30 with a pitch measured with respect to the axis RT corresponding to the pitch of the thread 30a.
- the dose scale consists of markings and numbers, each of which corresponds to a smallest adjustable dosage unit. The dose scale can be read during the adjustment of the dose to be administered through the window 4 of the housing section 3 ( FIG. 1 ).
- the actuating button 27 forms the proximal end of the injection device. He is clipped to the housing portion 3 by the housing portion 3 is provided at its proximal end with a shoulder 5, which engages behind the actuating knob 27.
- the operation knob 27 is rotatable relative to the housing 1-3 about the axis RT in a metering direction and a correction direction. In setting the dose, the dose is increased by the rotation of the operation knob 27 in the metering direction and reduced upon rotation in the direction of correction, whereby a dose set too large by mistake can be corrected.
- the actuating knob 27 is further axially movable with the coupling member 22, but connected by means of the engagement elements 25 against rotation.
- FIG. 5 shows the housing portion 3 and the operation knob 27 in clutch engagement, with a part of the operation button is cut away for the representation of the engagement.
- the operating knob 27 forms on the rotation with the coupling member 22 also has a slip clutch, in the exemplary embodiment a Drehloiskupplung with the housing section 3.
- a slip clutch in the exemplary embodiment a Drehrisonkupplung with the housing section 3.
- On the operating knob 27 are uniformly distributed for the formation of the slip clutch about the axis RT a plurality of locking elements 28 formed with the corresponding are the locking engagement elements 8 formed in a coupling engagement with the distal end of the housing section 3, preferably congruent locking counter-elements 8.
- the number of locking counter-elements 8 is less than the number of locking elements 28.
- the Der Actuating knob 27 is rotatable relative to the housing portion 3 about the axis RT in existing coupling engagement of the locking elements 28 and locking counter-elements 8, wherein the locking elements 28 and locking counter-elements 8 engage discretely distributed over the circumference locking positions in pairs releasably to each other.
- the slip clutch does not necessarily have to be formed directly between the housing 1-3 and the operating knob 27. Instead of providing the locking elements 28 on the actuating button 27, they could also be formed on the coupling member 22. Modified locking elements and locking counter-elements could, for example, axially engage in both embodiments instead of radially.
- the latching elements 28 and correspondingly the latching counter-elements 8 are asymmetrically shaped with respect to the direction of rotation, so that the force required for releasing the latching engagement in a coupling metering direction is greater than in the reverse direction of rotation, the coupling correction direction.
- the operation knob 27 since the operation knob 27 directly forms the latching elements 28 itself, the metering direction of the operation knob 27 is also the clutch metering direction at the same time, and the correction direction is the clutch correction direction.
- the locking counter-elements 8 are locking cams, which protrude from the outer shell surface of the housing portion 3 radially outward.
- the locking elements 28 are correspondingly formed on the facing opposite inner surface of the operating button 27 as corresponding recesses or tooth gaps of an internal toothing.
- the advancing flanks of the latching elements 28 pointing in the coupling metering direction are flatter than the flanks pointing in the reverse direction of rotation when the latching elements 28 move in the coupling metering direction.
- the locking counter-elements 8 are shaped to fit snugly with two flanks.
- the asymmetry of the slip clutch with respect to the two directions of rotation of the operating knob 27 is on the direction of the force from the member 32 to the metering and Indicator 30 applied force applied.
- the dosing namely on the metering coupling formed at 20, 24 and the guide engagement formed at 18 and 31, the dosing and indicating member 30 is threadedly rotated and moved in the proximal direction.
- the spring member 32 is increasingly tensioned.
- the elasticity force of the spring member 32 sets the movement of the dosing and indicating member 30 in the proximal direction a resistance which acts on the coupling described above on the slip clutch 8, 28 and the rotational movement of the actuating knob 27 in the metering direction, in which the flatter flanks of the Locking elements 28 and locking counter-elements 8 have, opposes an additional, during the metering increasing frictional resistance.
- the force exerted by the spring member 32 supports conversely the rotational movement in the direction of a dose correction.
- FIG. 5 shows the housing portion 3 and in particular its locking counter-elements 8 for the slip clutch 3, 27.
- the housing portion 3 forms in a proximal sleeve portion radially resilient compliant clutch springs 9, a clutch spring 9 per locking counter-element 8.
- the locking counter-elements 8 project from the clutch springs 9 each radially outward in front.
- the clutch springs 9 are ring segments. Circumferentially around the axis RT, the sleeve section is composed of alternately the clutch springs 9 and, in contrast, stiffer ring segments.
- the clutch springs 9 each act as a circumferentially extending bending beam, which are clamped on both sides, namely at the two ever next adjacent stiffer ring segments. In the circumferential direction extends along the clutch springs 9 each have a recess, whereby the resilience of the respective clutch spring 9 is increased.
- the sleeve section forming the coupling springs 9 forms the proximal end of the housing
- the actuating knob 27 is cup-shaped with a bottom forming the distal end of the injection device and a rising from the ground, rotating around the axis RT wall on the inner surface of the locking elements 8 are distributed uniformly over the circumference and each formed as an axially extending recess.
- the locking elements 28 are in the assembled state both with the locking counter-elements 8 as also with the engagement elements 25 (FIG. Fig. 3 ) of the coupling member 22 in engagement, wherein both the locking engagement with the locking counter-elements 8 and the anti-rotation engagement with the engagement elements 25 in each axial position of the actuating button 27 is maintained.
- the dosing and advancing device includes on the dosing clutch formed by the coupling members 16 and 22, a second clutch, namely the already also mentioned Aus featurekupplung, in FIG. 6 is shown.
- the Aus featurekupplung is formed by the coupling members 12 and 16, which are provided for this purpose with intermeshing engagement elements in the clutch engagement.
- On the side of the coupling member 12 are engagement elements 15a and 15b.
- the coupling member 16 is provided with engagement counterparts 21.
- the engagement elements 15a are axial ribs which protrude at the proximal end from a shell outer surface of the coupling member 12 radially outward.
- the engagement counter-elements 21 are formed on a shell inner surface at the proximal end of the coupling member 16 corresponding to axial blind grooves.
- the engagement counter-elements 21 form an axial guide for the engagement elements 15a.
- the engagement elements 15a form a kind of external toothing about the axis RT.
- the external toothing is interrupted at least one point, in the exemplary embodiment at two diametrically opposite points.
- each one of the engagement elements 15b is formed.
- the engaging elements 15b protrude radially outward like the engaging elements 15a, but are wider in the circumferential direction than the engaging elements 15a, so that they can not retract into the engaging elements 21 formed as blind grooves. Rather, the remaining between the engagement elements 21 rib webs form an axial stop for the engagement elements 15b when the coupling member 12 is moved relative to the coupling member 16 in the distal direction.
- the coupling member 16 is selectively connected to the coupling member 22 or the coupling member 12 in a clutch engagement, ie with dissolved discharge coupling in coupling engagement with the coupling member 22 and dissolved Dosierkupplung in coupling engagement with the coupling member 12.
- the dosing is closed, ie the Engagement elements 15a and 15b are in axial Covering only with the coupling member 22, the inner shell surface, however, is circumferentially smooth, so that when setting the dose, the coupling member 22 can rotate relative to the coupling member 12.
- the clutch member 12 is moved into clutch engagement with the metering and indicator member 16, the dosing clutch is thereby released and the distribution clutch is closed, so that the discharge can begin.
- Fig. 6 shows the coupling members 12, 16 and 22 in the state of the closed metering 16, 22nd
- the user can verify the level of the reservoir R or the position of the piston 10. Assume that he has already vented the reservoir R and wants to inject in the next step, a certain dose of the drug.
- the operating knob 27 By turning the operating knob 27 he sets the desired dose. During adjustment, he can read the current dose corresponding to the axial position of the metering and display member 30 through the window 4.
- the actuation knob 27 can correct the overdose by turning the actuation knob 27 in the direction of correction.
- the rotational movement of the actuating knob 27 is transmitted to the metering and indicating member 30 via the anti-rotation lock provided at 25, via the metering coupling closed at 20, 24 to the coupling member 16 and in the guiding engagement between 18 and 31.
- the metering and display member 30 moves in rotation with the threads 3a and 30a about the axis RT and translationally in the proximal direction.
- the spring member 32 is elastically increasingly stretched during the dosing and supports an optionally be made dose correction.
- the latching engagement of the slip clutch between the housing section 3 and the actuation button 27 produces a clearly perceptible clicking sound. Due to the steepness of the threads 3a and 30a, the dosing and display member 30 sets a correspondingly long adjustment in axial Direction back. Correspondingly large are the distances between the dose marks of the dose scale of the dosing and display member 30 in the axial direction, so that a clear reading of the straight under the window 4 continuous dosage mark is also guaranteed for visually impaired users.
- the piston rod 11 is decoupled from the dosing movement, in the exemplary embodiment dosing rotational movement, and is additionally secured by the surrounding, also decoupled coupling member 12 against rotational movements.
- the backup is obtained as already mentioned by the slip coupling formed between the coupling member 12 and the holding device 2a and the rotationally secured engagement of the coupling member 12 with the piston rod 11.
- the user When the desired dose is adjusted, the user pricks the puncture cannula into and under the skin into the subcutaneous tissue at the desired injection site. He then releases the release of the adjusted dose with the same hand, which also holds the injection device during insertion.
- the dosing and indicating member 30 is held in accordance with the dose-locking positions of the detent elements 28 and detent elements 8 of the slip clutch, ie, the slip clutch prevents the dosing and indicating member 30 from moving under the action of the spring member 32. Therefore, for disbursement, the coupling between the housing section 3 and the metering and indicating element 30 via the slip clutch at 8, 28 must be released. This is done by loosening the dosing coupling formed at 20, 24 by the user pressing the actuating button 27 with the thumb in the distal direction.
- the actuating knob 27 moves relative to the housing portion 3 and the coupling member 22 against the force of the spring 23 in the distal direction and presses against the coupling member 12 in this movement.
- the coupling member 12 axially springs in the region of its integrated spring 13 in one, so that its engagement elements 15a in the rotationally secured engagement with the engagement counter-elements 21 of the coupling member sixteenth reach.
- the metering coupling between the coupling member 22 and the coupling member 16 is still closed, while already the coupling engagement of the Aus thoroughlykupplung between the coupling member 12 and the coupling member 16 is made.
- the metering and indicator member 30 screws under the elasticity of the spring member 32 in the distal direction.
- the rotational movement portion of the dosing and indicating member 30 is transmitted to the coupling member 16 in the guiding engagement between the guide 18 and the engaging member 31.
- the coupling member 16 transmits because of the closed Aus featurekupplung the rotational movement of the coupling member 12, which in turn is non-rotatably connected to the piston rod 11, so that the piston rod 11 rotates in threaded engagement with the holding device 2a and pushes the piston 10 in the advancing direction V.
- the dispensing movement of the components involved is terminated by stopping the dosing and indicating member 30 on the shoulder 2c.
- the stroke or axial portion of the adjustment of the dosing and indicating member 30 therefore determines the stroke of the piston 10 and thus the distributed dose. Because of the greater thread pitch of the threads 3a and 30a relative to the threads of the piston rod 11 and the holding device 2a, the stroke of the metering and indicating member 30 is reduced to a stroke corresponding to the reduction ratio of the piston 10.
- the slip clutch formed between the spring 14 and the retainer 2a produces a clicking sound that is clearly perceptible and also acoustically indicates to the user that medication is being dispensed.
- the dispensing operation is also at least basically verifiable through the windows 1b and 2b based on the axial position of the piston 10.
- the stop member 26 is also moved in threaded engagement with the coupling member 22 in accordance with the set dose.
- the user exchanges the empty reservoir R for a filled new reservoir R. For this, he only has to separate the housing section 1 from the proximal housing section 2, 3, insert the new reservoir R with the piston 10 already received therein, and connect the housing sections 1 and 2, 3 again.
- all the springs are formed as an integral part of a respective coupling member with coupling part and spring part.
- one or more of the springs may alternatively be formed in a conventional manner as a steel spring separately from the respective coupling member.
- the springs 13, 17 and 23 can be readily replaced by steel springs, since they only fulfill the spring function.
- the spring 14 For the replacement of the spring 14, however, it requires a replacement spring and the formation of locking elements at the distal end of the coupling member 12th
- the spring member 32 may be arranged in axial overlap with the reservoir R and is supported on an abutment, for example, the shoulder 2c , In such a reversal of the installation conditions, the metering and display member 30 would be moved in the distribution in the proximal direction against a stop.
- the spring member 32 may be incorporated as a tension spring, although the installation is particularly preferred as a compression spring.
- German Patent Applications Nos. 10 2005 043 806.7 and 10 2005 043 807.5 described According to these applications, the spring member tuned to the slip clutch as described is incorporated as a torsion spring. The older applications are included with regard to the coordinated arrangement of slip clutch and spring member.
Abstract
Description
Die Erfindung betrifft eine Injektionsvorrichtung für ein injizierbares Produkt, vorzugsweise ein flüssiges Medikament wie beispielsweise Insulin, ein Wachstumshormon oder ein Osteoporosepräparat.The invention relates to an injection device for an injectable product, preferably a liquid medicament such as insulin, a growth hormone or an osteoporosis preparation.
Aus der
Es ist eine Aufgabe der Erfindung, eine Injektionsvorrichtung zu schaffen, die ein sicheres Einstellen einer zu verabreichenden Dosis ohne besonderen Kraftaufwand einschließlich einer Dosiskorrektur erlaubt.It is an object of the invention to provide an injection device which allows a safe setting of a dose to be administered without any special effort including a dose correction.
Die Erfindung betrifft eine Injektionsvorrichtung, die ein Gehäuse mit einem Reservoir für ein injizierbares Produkt, einen Betätigungsknopf für die Einstellung einer Pröduktdosis, ein Förderglied für die Ausschüttung der eingestellten Dosis, eine Zweiwege-Rutschkupplung und ein Federglied umfasst. Der Betätigungsknopf ist für die Einstellung der Dosis relativ zu dem Gehäuse in eine die Dosis vergrößernde Dosierrichtung und eine die Dosis verringernde Korrekturrichtung beweglich. Vorzugsweise ist der Betätigungsknopf relativ zu dem Gehäuse drehbeweglich. Obgleich weniger bevorzugt, kann der Betätigungsknopf für die Einstellung der Dosis relativ zu dem Gehäuse auch nur linear beweglich oder in noch einer alternativen Ausführung linear- und drehbeweglich sein. In bevorzugten einfachen Ausführungen bilden das Gehäuse und der Dosierknopf je ein Gelenkglied eines gemeinsam gebildeten Drehgelenks. Grundsätzlich kann der Dosierknopf jedoch auch erst über ein oder mehrere weitere Gelenkelemente und dementsprechend mehrere Gelenke mit dem Gehäuse beweglich verbunden sein. Zweckmäßigerweise kann ein in dem Reservoir linear beweglich aufgenommener Förderkolben das Förderglied bilden.The invention relates to an injection device comprising a housing with an injectable product reservoir, a pres # dose adjustment knob, a set dose delivery spreader, a two-way slipper clutch, and a spring member. The actuation knob is movable to adjust the dose relative to the housing in a dose-increasing dosage direction and a dose-reducing correction direction. Preferably, the actuating knob is rotatable relative to the housing. Although less preferred, the dose adjustment knob may also be linearly movable or rotationally movable relative to the housing, or, in yet an alternative embodiment, linearly movable. In preferred simple embodiments, the housing and the dosing button each form a joint member of a jointly formed pivot joint. In principle, however, the dosing button can also be movably connected to the housing only via one or more further joint elements and correspondingly a plurality of joints. Conveniently, a linearly movably received in the reservoir conveyor piston form the conveyor member.
Die Zweiwege-Rutschkupplung umfasst wenigstens ein Rastelement und wenigstens ein Rastgegenelement, die in einem Rasteingriff miteinander verrastend den Dosierknopf bei einer Bewegung in die Dosierrichtung und bei einer Bewegung in die Korrekturrichtung jeweils in diskreten Rastpositionen mit dem Gehäuse form- und kraftschlüssig koppeln. Das Federglied wirkt der Bewegung des Dosierknopfs in wenigstens eine der beiden Richtungen, vorzugsweise der Bewegung in die Dosierrichtung, mit einer elastischen Federkraft entgegen.The two-way slip clutch comprises at least one latching element and at least one locking counter-element, the latching in a latching engagement with each other dosing the knob when moving in the metering direction and during movement in the correction direction in discrete detent positions with the housing positively and non-positively. The spring member counteracts the movement of the Dosierknopfs in at least one of the two directions, preferably the movement in the metering direction, with an elastic spring force.
Nach der Erfindung ist oder sind das Rastelement oder das Rastgegenelement in Abstimmung auf die Federkraft so geformt, dass sie im Rasteingriff der Bewegung in die durch die Federkraft begünstigte Richtung einen größeren Widerstand entgegensetzen als der Bewegung in die andere Richtung. Das Wort "oder" wird hier wie auch im übrigen im üblichen logischen Sinne von "und/oder" verwendet, soweit sich aus dem Zusammenhang des jeweiligen Gebrauchs des Worts kein anderer Sinn ergibt. Die Form des Rastelements oder des Rastgegenelements ist bevorzugt so gewählt, dass die Rutschkupplung der Bewegung des Betätigungsknopfs in die Korrekturrichtung einen größeren Widerstand als der Bewegung in die Dosierrichtung entgegensetzt und der für das Aufdosieren zu überwindende Reibwiderstand formbedingt geringer ist als der für die Dosiskorrektur zu überwindende Reibwiderstand.According to the invention, the locking element or the counter-locking element in response to the spring force is shaped so that they oppose in the latching engagement of the movement in the direction favored by the spring force greater resistance than the movement in the other direction. The word "or" is used here as well as otherwise in the usual logical sense of "and / or", as far as no other meaning arises from the context of the respective use of the word. The shape of the latching element or the latching counter element is preferably selected so that the slip clutch opposes the movement of the actuating button in the correction direction greater resistance than the movement in the metering direction and the frictional resistance to be overcome for the metering form is lower than that for the dose correction to be overcome frictional resistance.
In bevorzugter Ausführung wird das Federglied durch die Bewegung des Betätigungsknopfs in die wenigstens eine Richtung von Rastposition zu Rastposition stärker gespannt. Aufgrund des erfindungsgemäß geformten Rastelements oder Rastgegenelements kann ein versehentliches Durchrutschen der Kupplung in die andere Richtung, in die nämlich das Federglied wirkt, sicherer als im Stand der Technik verhindert werden, während gleichzeitig der durch die Form des wenigstens einen Rastelements oder Rastgegenelements bedingte Widerstand gegen die Bewegung in die wenigstens eine Richtung geringer als im Falle einer herkömmlichen, bezüglich der Bewegungsrichtung indifferenten Rutschkupplung sein kann. Aufgrund der Erfindung kann der für das Einstellen der Dosis erforderliche Kraftaufwand gegenüber dem Stand der Technik verringert und die Haltekraft der Kupplung dennoch vergrößert werden. Ebenso kann bei gleich bleibender Haltekraft der Kraftaufwand für die Einstellung der Dosis verringert oder bei gleich bleibendem Kraftaufwand die Haltekraft der Rutschkupplung vergrößert werden.In a preferred embodiment, the spring member is stretched by the movement of the actuating knob in the at least one direction from locking position to locking position stronger. Due to the inventively formed locking element or locking counter element accidental slippage of the clutch in the other direction, in which the spring member acts, are safer than in the prior art to be prevented, while at the same time due to the shape of the at least one locking element or locking counter-element resistance to the Movement in the at least one direction may be less than in the case of a conventional, with respect to the direction of movement indifferent slip clutch. By virtue of the invention, the force required for adjusting the dose can be reduced compared with the prior art and the holding force of the coupling can nevertheless be increased. Likewise, the force required for the adjustment of the dose can be reduced or the holding force of the slip clutch can be increased while maintaining the same holding force.
Das Federglied kann eine Kupplungsfeder bilden, gegen deren Federkraft das Rastelement und Rastgegenelement sowohl bei der Bewegung in die Dosierrichtung als auch bei der Bewegung in die Korrekturrichtung voneinander wegbewegt werden, um in der jeweils nächsten Rastposition wieder zu verrasten. Die Federkraft kann für beide Bewegungsrichtungen in jeder Rastposition die gleiche sein. Bevorzugter wird jedoch das Federglied bei der Bewegung in die wenigstens eine der Richtungen von Rastposition zu Rastposition stärker gespannt, so dass es der Bewegung in die betreffende Richtung eine größere Federkraft entgegensetzt als in die andere: Dabei kann es der Bewegung in die andere Richtung ebenfalls eine, wenn auch kleinere Federkraft entgegensetzen.The spring member may form a coupling spring, against the spring force, the locking element and locking counter element are moved away from each other both in the movement in the metering direction and during the movement in the correction direction to lock in the next locking position again. The spring force can be the same for both directions of movement in each locking position. However, this is more preferable Spring member during the movement in the at least one of the directions of detent position to detent position more tense, so that it opposes the movement in the direction in question a greater spring force than in the other: It may be the movement in the other direction also one, albeit smaller Counteract spring force.
In bevorzugten Ausführungen setzt das Federglied nur der Bewegung in die wenigstens eine der beiden Richtungen eine Federkraft entgegen. In derartigen Ausführungen dient das Federglied nicht als Kupplungsfeder. Vorteilhafterweise ist in solchen Ausführungen eine Kupplungsfeder als weiteres Federglied oder sind mehrere Kupplungsfedern als weitere Federglieder vorgesehen, so dass das Rastelement und Rastgegenelement in beide Bewegungsrichtungen gegen die Elastizitätskraft der separaten Kupplungsfeder oder der mehreren separaten Kupplungsfedern von Rastposition zu Rastposition bewegbar sind. Die funktionale Entlastung des Federglieds in dieser Hinsicht eröffnet Gestaltungsspielraum hinsichtlich der Form und des Einbaus des Federglieds. Ferner kann das Federglied einfacher in einer anderen Zusatzfunktion verwendet werden. Desweiteren kann die Rutschkupplung mittels der wenigstens einen separaten Kupplungsfeder oder der mehreren separaten Kupplungsfedern im Hinblick auf ihre Haltekraft und den für die Überwindung der Haltekraft erforderlichen Kraftaufwand optimiert werden.In preferred embodiments, the spring member counteracts only the movement in the at least one of the two directions of a spring force. In such embodiments, the spring member does not serve as a clutch spring. Advantageously, in such embodiments, a clutch spring as a further spring member or a plurality of clutch springs are provided as further spring members, so that the locking element and locking counter-member are movable in both directions of movement against the elasticity of the separate clutch spring or the plurality of separate clutch springs from locking position to locking position. The functional relief of the spring member in this regard opens up design freedom in terms of the shape and the installation of the spring member. Furthermore, the spring member can be used more easily in another additional function. Furthermore, the slip clutch can be optimized by means of at least one separate clutch spring or the plurality of separate clutch springs in terms of their holding power and the effort required to overcome the holding force.
Das Federglied ist vorzugsweise eine mechanische Feder, kann alternativ aber auch eine pneumatische Feder sein. Der Funktion nach kann das Federglied insbesondere eine Druckfeder oder eine Torsionsfeder, gegebenenfalls auch eine Zugfeder sein. In bevorzugten Ausführungen ist das Förderglied bei der Ausschüttung der Dosis mittels des Federglieds antreibbar. In einer bevorzugten ersten Variante wird das Förderglied bei der Ausschüttung nur von dem Federglied angetrieben. In einer ebenfalls bevorzugten zweiten Variante muss der Benutzer die für den Antrieb des Förderglieds erforderliche Kraft zumindest zu einem Teil aufbringen, und das Förderglied erfüllt die Funktion einer Servofeder, die den Benutzer unterstützt, so dass sich bei der Ausschüttung der Benutzer und das Federglied die für den Antrieb des Förderglieds erforderliche Kraft teilen. Ein bevorzugtes Beispiel für die zweite Variante wird in der deutschen Patentanmeldung Nr.
Das Rastelement und das Rastgegenelement sind von Rastposition zu Rastposition in eine Kupplungsdosierrichtung und eine Kupplungskorrekturrichtung bewegbar. Vorzugsweise sind die Kupplungsdosierrichtung und die Kupplungskorrekturrichtung einander entgegengerichtet. Vorteilhafterweise ist der Betätigungsknopf mit einem aus Rastelement und Rastgegenelement so verbunden, dass die Kupplungsdosierrichtung der Dosierrichtung und die Kupplungskorrekturrichtung der Korrekturrichtung des Betätigungsknopfs entsprechen. Vorzugsweise ist das eine aus Rastelement und Rastgegenelement an dem Betätigungsknopf geformt oder befestigt, so dass es dessen Bewegung mitmacht. Das eine aus Rastelement und Rastgegenelement kann mit dem Betätigungsknopf aber auch erst über ein oder mehrere Zwischenglieder kinematisch, d.h. schlupffrei, gekoppelt sein. In derartigen Ausführungen kann die Kupplungsdosierrichtung von der Dosierrichtung des Betätigungsknopfs abweichen. Entsprechendes gilt für die Kupplungskorrekturrichtung und die Korrekturrichtung des Betätigungsknopfs. In sämtlichen Ausführungen gilt jedoch, dass sich das Rastelement relativ zu dem Rastgegenelement in die Kupplungsdosierrichtung bewegt, wenn der Betätigungsknopf in die Dosierrichtung bewegt wird, und sich in die Kupplungskorrekturrichtung bewegt, wenn der Betätigungsknopf in die Korrekturrichtung bewegt wird.The locking element and the locking counter-element are movable from locking position to locking position in a Kupplungsdosierrichtung and a coupling correction direction. Preferably, the Kupplungsdosierrichtung and the coupling correction direction are opposite to each other. Advantageously, the actuating knob is connected to a latching element and latching counter element so that the Kupplungsdosierrichtung the metering direction and the coupling correction direction correspond to the correction direction of the actuating knob. Preferably, the one of locking element and locking counter-element is formed or fixed to the actuating button so that it participates in the movement. The one of latching element and latching counter element can kinematically with the operating knob but also via one or more intermediate links, i. slip-free, be coupled. In such embodiments, the Kupplungsdosierrichtung may differ from the metering direction of the operating knob. The same applies to the clutch correction direction and the correction direction of the actuating button. In all embodiments, however, it applies that the detent member moves relative to the detent counterpart in the Kupplungsdosierrichtung when the operating knob is moved in the metering direction, and moves in the coupling correction direction when the operating knob is moved in the direction of correction.
Die Rutschkupplung umfasst wenigstens zwei Kupplungshälften, nämlich eine erste Kupplungshälfte mit dem wenigstens einen Rastelement und eine zweite Kupplungshälfte mit dem wenigstens einen Rastgegenelement. Das Rastelement und das Rastgegenelement sind an der jeweiligen Kupplungshälfte vorzugsweise in einem Stück angeformt, d.h. stoffschlüssig mit der zugeordneten Kupplungshälfte verbunden oder bevorzugter gleich bei der Urformung angeformt. Alternativ können sie an der jeweiligen Kupplungshälfte auch befestigt sein. In bevorzugten Ausführungen ist die Rutschkupplung eine Drehrutschkupplung, wobei eine der Kupplungshälften relativ zu der anderen zumindest für die Einstellung der Dosis um eine Drehachse drehbeweglich ist. Bevorzugt bildet das Gehäuse eine der Kupplungshälften. Ein separat gefertigtes, aber fest mit einer Gehäuseschale verbundenes Teil wird als zu dem Gehäuse gehörig gerechnet. Alternativ kann auch eine bezüglich der Drehachse verdrehgesichert mit dem Gehäuse, in anderer Weise jedoch relativ zu dem Gehäuse bewegliche Struktur, insbesondere eine axial bewegliche Struktur, eine der Kupplungshälften bilden. Grundsätzlich können sogar beide Kupplungshälften relativ zu dem Gehäuse um die Drehachse drehbeweglich sein, wobei allerdings eine der Kupplungshälften zumindest bei der Einstellung der Dosis verdrehgesichert mit dem Gehäuse verbunden oder gegebenenfalls über ein Getriebe mit dem Gehäuse gekoppelt ist. Falls eine mit dem Gehäuse verdrehgesichert verbundene, relativ zu dem Gehäuse jedoch axial bewegliche Struktur eine der Kupplungshälften bildet, wird es bevorzugt, wenn der Betätigungsknopf sich bei dem Einstellen der Dosis und auch bei dem Ausschütten gemeinsam mit der axial beweglichen Struktur in die axiale Richtung bewegt, wie dies insbesondere in der deutschen Patentanmeldung Nr.
In bevorzugten Ausführungen umfasst die Rutschkupplung genau zwei Kupplungshälften, d.h. sie besteht in derartigen Ausführungen aus den genannten Kupplungshälften, und das Rastelement und das Rastgegenelement greifen im Rasteingriff ineinander. In hierzu alternativen Ausführungsformen umfasst die Rutschkupplung die zwei Kupplungshälften und ferner ein zwischen den Kupplungshälften angeordnetes Übertragungsglied. Das Übertragungsglied ist mit einer ersten der zwei Kupplungshälften in einem Rasteingriff und mit der zweiten der Kupplungshälften in einem weiteren Rasteingriff, vorzugsweise bildet es mit den beiden Kupplungshälften je eine Drehrutschkupplung. Eine derartige Rutschkupplung wird in der
In der
Das wenigstens eine Rastelement oder das wenigstens eine Rastgegenelement ist oder sind in bevorzugten Ausführungen in Bezug auf die beiden Richtungen, in welche sie relativ zueinander hin und her bewegbar sind, asymmetrisch geformt. Die Asymmetrie ist vorzugsweise derart, dass für die Bewegung des Betätigungsknopfs in die Korrekturrichtung eine größere Kraft aufgewendet werden muss als für die Bewegung in die Dosierrichtung. Der im Rasteingriff von Rastelement und Rastgegenelement zu überwindende Widerstand ist in die Korrekturrichtung somit größer als in die Dosierrichtung. Das Rastelement und Rastgegenelement, die einen Rastvorsprung und eine Rastvertiefung darstellen, weisen bezüglich den beiden Richtungen ihrer Relativbeweglichkeit Flanken auf, die in Bezug auf die beiden Richtungen asymmetrisch sind, indem eine in die eine der beiden Richtungen weisende Flanke des Rastelements oder des Rastgegenelements steiler ist als die in die andere Richtung weisende Flanke des gleichen Elements. Grundsätzlich genügt es, wenn nur das Rastelement oder nur das Rastgegenelement asymmetrisch geformt ist. Eine aufeinander angepasste, kongruente Form von Rastelement und Rastgegenelement wird jedoch bevorzugt.The at least one latching element or the at least one latching counter-element is or are asymmetrically shaped in preferred embodiments with respect to the two directions in which they are reciprocable relative to each other. The asymmetry is preferably such that a greater force must be expended for the movement of the actuating button in the direction of correction than for the movement in the metering direction. The resistance to be overcome in the latching engagement of latching element and latching counter element is thus greater in the correction direction than in the metering direction. The latching element and locking counter-element, which constitute a latching projection and a latching recess, have flanks with respect to the two directions of their relative movement flanks, which are asymmetrical with respect to the two directions by a steeper in one of the two directions edge of the locking element or the counter-locking element is steeper as the flank of the same element pointing in the other direction. In principle, it is sufficient if only the locking element or only the locking counter-element is asymmetrically shaped. An adapted, congruent form of locking element and locking counter-element is preferred.
Das Rastelement und das Rastgegenelement der Rutschkupplung, nämlich das Rastelement und Rastgegenelement der einander kontaktierenden Kupplungshälften in der einen Ausführung und die wenigstens zwei Paare aus Rastelement und Rastgegenelement der beiden Kupplungshälften und des Übertragungsglieds in der alternativen Ausführung, können an den Kupplungshälften und dem optionalen Übertragungsglied unnachgiebig angeordnet sein. In diesem Fall ist wenigstens eine der Kupplungshälften oder das optionale Übertragungsglied im Ganzen gegen eine Federkraft elastisch nachgiebig gelagert, damit die Rutschkupplung im Rasteingriff bewegt werden kann. In bevorzugten Ausführungen ist jedoch das Rastelement oder Rastgegenelement an der betreffenden Kupplungshälfte oder dem optionalen Übertragungsglied elastisch nachgiebig angeordnet. Insbesondere kann jedes Rastelement oder Rastgegenelement einen elastischen Schnapper bilden, indem pro Rastelement oder Rastgegenelement eine Kupplungsfeder vorgesehen ist, von welcher das zugehörige Rastelement abragt oder als Rastvertiefung ausgenommen ist. Obgleich sowohl das Rastelement als auch das Rastgegenelement je als elastischer Schnapper gebildet sein kann, wird es bevorzugt, wenn nur eines aus Rastelement und Rastgegenelement elastisch nachgiebig und das andere unnachgiebig ist.The locking element and the locking counter-element of the slip clutch, namely the locking element and locking counter-element of the mutually contacting coupling halves in one Embodiment and the at least two pairs of locking element and locking counter-element of the two coupling halves and the transmission member in the alternative embodiment, can be placed relentlessly on the coupling halves and the optional transmission member. In this case, at least one of the coupling halves or the optional transmission member is supported elastically resiliently against a spring force as a whole, so that the friction clutch can be moved in the latching engagement. In preferred embodiments, however, the locking element or locking counter-element is arranged elastically yielding to the respective coupling half or the optional transmission member. In particular, each locking element or locking counter-element form an elastic snapper by per locking element or locking counter-element, a clutch spring is provided, from which the associated locking element protrudes or is excluded as a detent recess. Although both the locking element and the locking counter-element can each be formed as an elastic snapper, it is preferred if only one of locking element and locking counter-element is elastically yielding and the other is relentless.
Die Kupplungsfeder kann insbesondere ein elastischer Biegebalken sein, der entweder nur einseitig eingespannt ist und von seiner Einspannung frei vorragt, vorzugsweise in Umfangsrichtung um die Drehachse, falls die Rutschkupplung als Drehrutschkupplung gebildet ist. Besonders bevorzugt ist die Kupplungsfeder als beidseits eingespannter Biegebalken gebildet. Die betreffende Kupplungshälfte kann hierfür beispielsweise als Hülse mit innenliegender Drechachse geformt sein, zumindest in einem das Rastelement oder Rastgegenelement bildenden Abschnitt. Um den Biegebalken zu erhalten, ist die Hülse axial neben dem Biegebalken mit einem Durchbruch versehen, neben dem der Biegebalken als Brückenelement stehen bleibt. In Umfangsrichtung gesehen können auf diese Weise hintereinander mehrere Biegebalken mit dazwischen verbleibenden steiferen Hülsensegmenten erhalten werden.The clutch spring may in particular be an elastic bending beam, which is either clamped only on one side and protrudes freely from its clamping, preferably in the circumferential direction about the axis of rotation, if the slip clutch is formed as Drehrutschkupplung. Particularly preferably, the clutch spring is formed as both sides clamped bending beam. The relevant coupling half can be formed for this purpose, for example, as a sleeve with an internal axis of rotation, at least in a section forming the detent element or detent counter element. In order to obtain the bending beam, the sleeve is provided axially adjacent to the bending beam with an opening, next to the bending beam remains as a bridge element. Seen in the circumferential direction can be obtained in this way one behind the other several bending beam with the remaining remaining stiffer sleeve segments.
In bevorzugten Ausführungen, in denen das Federglied bei der Bewegung des Betätigungsknopfs in die Dosierrichtung gespannt wird und die bei der Einstellung der Dosis aufgenommene Federenergie bei der Ausschüttung das Förderglied allein oder unterstützend antreibt, wirkt das Federglied vorteilhafterweise direkt oder gegebenenfalls auch erst über ein oder mehrere Zwischenglieder auf ein Dosierglied, das für die Einstellung der Dosis relativ zu dem Gehäuse hin und her beweglich ist. Bei der Ausschüttung wird das Dosierglied in eine der beiden Richtungen seiner Beweglichkeit bis gegen einen Ausschüttanschlag bewegt. Vorzugsweise ist es auch in die andere Richtung der Beweglichkeit bis gegen einen Maximaldosis-Anschlag beweglich. Die Beweglichkeit des Dosierglieds kann eine reine Translationsbeweglichkeit oder eine reine Rotationsbeweglichkeit sein, vorzugsweise handelt es sich um eine sowohl translatorische als auch rotatorische Beweglichkeit. So kann das Dosierglied insbesondere ein Gelenkelement eines Schraubgelenks sein. Im Falle eines drehbeweglichen Dosierglieds ist vorzugsweise wenigstens einer der genannten Anschläge ein Verdrehanschlag.In preferred embodiments, in which the spring member is stretched during the movement of the actuating knob in the metering direction and the spring energy absorbed in the setting of the dose drives the delivery member alone or supportive in the distribution, the spring member advantageously acts directly or optionally only one or more Intermediate links on a dosing member, for the Adjustment of the dose relative to the housing is movable back and forth. In the distribution, the dosing is moved in one of the two directions of its mobility up against a Ausschüttanschlag. Preferably, it is also movable in the other direction of mobility up to a maximum dose stop. The mobility of the dosing member may be a pure translational mobility or a pure rotational mobility, it is preferably a both translational and rotational mobility. Thus, the dosing member may in particular be a joint element of a screw joint. In the case of a rotatable dosing preferably at least one of said stops is a rotational stop.
Obgleich es grundsätzlich genügt, wenn die Rutschkupplung nur ein einziges Rastelement und ein einziges Rastgegenelement oder in Ausführungen mit Übertragungsglied nur zwei Paare aus je nur einem Rastelement und einem Rastgegenelement umfasst, wird es bevorzugt, wenn pro Rasteingriff mehrere Rastelemente und mehrere Rastgegenelement vorgesehen sind. Es kann im jeweiligen Rasteingriff auch nur ein einziges Rastelement mit mehreren Rastgegenelementen verrasten, nämlich von Rastposition zu Rastposition jeweils mit dem nächsten Rastgegenelement. Hinsichtlich nur eines einzigen Rastgegenelements pro Rasteingriff gilt sinngemäß das gleiche. Bei mehreren Rastelementen oder Rastgegenelementen genügt es hinsichtlich des Merkmals der asymmetrischen Form, wenn nur eines der Elemente dieses Merkmal aufweist. Bevorzugt sind jedoch sämtliche Rastelemente oder Rastgegenelemente der Rutschkupplung so geformt.Although it is basically sufficient if the slip clutch comprises only a single locking element and a single locking counter-element or in embodiments with transfer member only two pairs of only one locking element and a locking counter-element, it is preferred if each locking engagement several locking elements and a plurality of locking counter-element are provided. It can lock in the respective latching engagement, even a single locking element with a plurality of locking counter-elements, namely from locking position to locking position in each case with the next locking counter-element. With regard to only a single locking counter-element per latch engagement applies mutatis mutandis, the same. In the case of a plurality of latching elements or latching counter-elements, it is sufficient with regard to the feature of the asymmetrical shape if only one of the elements has this feature. Preferably, however, all locking elements or locking counter-elements of the slip clutch are shaped.
Weitere bevorzugte Merkmale werden auch in den Unteransprüchen und deren Kombinationen beschrieben. Die dort beschriebenen Merkmale und die vorstehend erläuterten Ausgestaltungen ergänzen einander wechselseitig.Further preferred features are also described in the subclaims and their combinations. The features described therein and the embodiments described above complement each other mutually.
Nachfolgend wird ein Ausführungsbeispiel der Erfindung anhand von Figuren erläutert. An dem Ausführungsbeispiel offenbar werdende Merkmale bilden je einzeln und in jeder Merkmalskombination die Gegenstände der Ansprüche und die vorstehend beschriebenen Ausgestaltungen vorteilhaft weiter. Es zeigen:
Figur 1- eine Injektionsvorrichtung in einer Ansicht,
Figur 2- die Injektionsvorrichtung in einem Längsschnitt,
Figur 3- den proximalen Abschnitt der Injektionsvorrichtung in dem Längsschnitt,
- Figur 4
- eine Dosierkupplung in einem Kupplungseingriff,
Figur 5- einen Gehäuseabschnitt und einen Betätigungsknopf und
- Figur 6
- eine Ausschüttkupplung außer Eingriff.
- FIG. 1
- an injection device in a view
- FIG. 2
- the injection device in a longitudinal section,
- FIG. 3
- the proximal portion of the injection device in the longitudinal section,
- FIG. 4
- a metering clutch in a clutch engagement,
- FIG. 5
- a housing section and an actuating button and
- FIG. 6
- a Ausschüttkupplung disengaged.
Die
Das Reservoir R ist eine Ampulle aus Glas oder durchsichtigem Kunststoff. In dem Reservoir R ist ein Kolben 10 in eine Vortriebsrichtung V auf den Auslass 1a zu axial beweglich aufgenommen. In dem in den
Die den proximalen Gehäuseabschnitt bildenden Abschnitte 2 und 3 sind ebenfalls fest miteinander verbunden, vorzugsweise stoffschlüssig, und können funktional als ein einziger Gehäuseabschnitt 2, 3 betrachtet werden. Der Gehäuseabschnitt 2, 3 lagert eine Dosier- und Vortriebseinrichtung, mittels der eine pro Injektion ausschüttbare Dosis des Medikaments einstellbar und die eingestellte Dosis durch Vortrieb des Kolbens 10 ausschüttbar ist. Der Betätigungsknopf 27 ist für die Einstellung der Dosis mittels einer Dosierkupplung mit der Dosier- und Vortriebseinrichtung gekoppelt.The
Die Dosier- und Vortriebseinrichtung umfasst mehrere Glieder, die mittels der Dosierkupplung und einer Ausschüttkupplung bei der Einstellung der Dosis und deren Aufschüttung auf unterschiedliche Weise miteinander gekoppelt sind. Eine Kolbenstange 11 bildet eines dieser Glieder. Bei der Ausschüttung drückt die Kolbenstange 11 gegen die Rückseite des Kolbens 10, so dass dieser sich in die Vortriebsrichtung V bewegt und Medikament durch den Auslass 1a ausgeschüttet wird. Die Kolbenstange 11 ist mit dem Gehäuseabschnitt 2 in einem Gewindeeingriff, für den sie über den größten Teil ihrer Länge mit einem Gewinde versehen ist. Der Gehäuseabschnitt 2 bildet das Gegengewinde an einer nach radial einwärts gegen die Kolbenstange 11 ragenden Halteeinrichtung 2a (
Die Dosier- und Vortriebseinrichtung umfasst ferner ein erstes Kupplungsglied 12, ein zweites Kupplungsglied 16 und ein drittes Kupplungsglied 22. Das Kupplungsglied 12 ist mit der Kolbenstange 11 längs deren Flachseite oder Nut in einem Führungseingriff axial beweglich, aber verdrehgesichert verbunden. Das Kupplungsglied 12 ist proximal von der Halteeinrichtung 2a angeordnet und drückt in die Vortriebsrichtung V gegen die Halteeinrichtung 2a. Das Kupplungsglied 12 umgibt die Kolbenstange 11. Das Kupplungsglied 12 umfasst einen distalen Abschnitt, der die Halteeinrichtung 2a kontaktiert, und einen proximalen Abschnitt, der sich bis zu dem Betätigungsknopf 27 erstreckt. Zwischen den beiden Abschnitten ist eine Feder 13 gebildet. An dem distalen Ende des Kupplungsglieds 12 ist eine weitere Feder 14 geformt, die mehrere in Richtung auf die Halteeinrichtung 2a ragende Federzungen umfasst, die elastisch gespannt sind. Die Federzungen der Feder 14 bilden Rastelemente, die mit Rastgegenelementen der Halteeinrichtung 2a verrasten, so dass zwischen dem Kupplungsglied 12 und der Halteeinrichtung 2a und somit dem Gehäuseabschnitt 2 eine Drehrutschkupplung erhalten wird, die verhindert, dass die Kolbenstange 11 sich bei Erschütterungen relativ zu dem Gehäuse 1-3 drehen kann. Die im Kupplungseingriff der Rastelemente und Rastgegenelemente der Drehrutschkupplung übertragbare Kraft ist jedoch nicht so groß, dass sie die für das Ausschütten der eingestellten Dosis erforderliche Drehbewegung der Kolbenstange 11 verhindert oder in einem praktisch relevanten Ausmaß auch nur behindert. In dem Abschnitt der Feder 13 kann das Kupplungsglied 12 axial einfedern. Das Kupplungsglied 12 ist einschließlich der beiden Federn 13 und 14 in einem Stück aus Kunststoff geformt, vorzugsweise im Spritzguss.The metering and advancing device further comprises a
Das Kupplungsglied 16 ist um die Achse RT drehbar gelagert. Es ist hülsenförmig und umgibt das Kupplungsglied 12. An dem distalen Ende des Kupplungsglieds 16 ist eine Feder 17, im Ausführungsbeispiel eine axial kurze Schraubenfeder, in einem Stück angeformt. Das Kupplungsglied 16 stützt sich mit seiner Feder 17 in die distale Richtung an dem Kupplungsglied 12 ab und drückt dieses gegen die Halteeinrichtung 2a. An dem proximalen Ende des Kupplungsglieds 16 sind Eingriffselemente 20 geformt, die in dem dargestellten Zustand der Injektionsvorrichtung in einem lösbaren Kupplungseingriff mit Eingriffsgegenelementen 24 des Kupplungsglieds 22 sind. Die Eingriffselemente 20 und Eingriffsgegenelemente 24 können axial vom Kupplungsglied 16 oder 22 in Richtung auf das jeweils andere ragende Zähne sein, die zwei im Kupplungseingriff ineinander greifende, zu der Achse RT konzentrische Zahnkränze mit vorzugsweise gleichmäßiger Zahnteilung bilden, wie dies in
Das Kupplungsglied 22 ist ebenfalls hülsenförmig und weist an seinem proximalen Ende einen nach radial außen ragenden Flansch auf. An dem äußeren Umfang des Flansches sind Eingriffselemente 25 geformt, die das Kupplungsglied 22 verdrehgesichert mit dem Betätigungsknopf 27 verbinden. Das Kupplungsglied 22 stützt sich über eine Feder 23 axial an dem Betätigungsknopf 27 ab. Die Feder 23 ist integrierter Bestandteil des Kupplungsglieds 22, indem das Kupplungsglied 22 in einem Stück einschließlich der Feder 23 aus Kunststoff geformt ist. Die Feder 23 besteht ähnlich wie die Feder 14 aus mehreren, um die Achse RT gebogenen sowie axial abragenden Federzungen. Sie sorgt in Verbindung mit der Feder 17 dafür, dass die Kupplungsglieder 16 und 22 axial elastisch in dem Kupplungseingriff gehalten werden. Die Feder 17 drückt das Kupplungsglied 16 und die Feder 23 drückt das Kupplungsglied 22 des Weiteren je axial auf Anschlag gegen den Gehäuseabschnitt 3.The
Das Kupplungsglied 22 ist mit einem Stoppglied 26 in einem Gewindeeingriff. Hierfür ist das Kupplungsglied 22 an seinem äußeren Umfang vor dem Flansch mit einem Gewinde 22a versehen (
Die Dosier- und Vortriebseinrichtung umfasst ferner ein Dosier- und Anzeigeglied 30, das mit dem Gehäuseabschnitt 3 in einem Gewindeeingriff ist. Für diesen Gewindeeingriff ist der Gehäuseabschnitt 3 mit einem Innengewinde 3a versehen. Der Gehäuseabschnitt 2 ist im Kontaktbereich mit dem Dosier- und Anzeigeglied 30 glatt. Das Gewinde 3a ist unmittelbar an der Mantelinnenfläche der kreiszylindrischen Hüllschale des Gehäuseabschnitts 2, 3 gebildet. Das Dosier- und Anzeigeglied 30 ist im Wesentlichen eine einfach kreiszylindrische Hülse mit einem entsprechend geformten Außengewinde 30a. Die Gewinde 3a und 30a haben eine deutlich größere Gewindesteigung als die Gewinde der Kolbenstange 11 und der Halteeinrichtung 2a. Die Gewindesteigung ist so groß, dass eine Selbsthemmung im Gewindeeingriff verhindert wird und das Dosier- und Anzeigeglied 30 unter einer reinen Axialkraft im Gewindeeingriff relativ zu dem Gehäuseabschnitt 2, 3 dreht und axial bewegt wird.The metering and advancing device further comprises a metering and
Das Dosier- und Anzeigeglied 30 ist axial beweglich, aber verdrehgesichert mit dem Kupplungsglied 16 gekoppelt. Im Ausführungsbeispiel sind das Dosier- und Anzeigeglied 30 und das Kupplungsglied 16 unmittelbar miteinander in einem entsprechenden Führungseingriff. Das Kupplungsglied 16 bildet hierfür eine axiale Führung 18 an seinem äußeren Umfang. An der Mantelinnenfläche des Dosier- und Anzeigeglieds 30 ist ein Eingriffselement 31 abragend geformt, mit dem das Dosier- und Anzeigeglied 30 in Führungseingriff mit dem Kupplungsglied 16, d. h. mit dessen Führung 18, ist. Die Führung 18 erstreckt sich über den größten Teil der Länge des Kupplungsglieds 16 und wird von dem Dosier- und Anzeigeglied 30 bei Einstellung der Maximaldosis über den größten Teil ihrer Länge durchfahren. Die Führung 18 wird von axialen Nuten in der Mantelaußenfläche des Kupplungsglieds 16 gebildet (
Die Dosier- und Vortriebseinrichtung umfasst schließlich ein Federglied 32, welches das Dosier- und Anzeigeglied 30 in die distale Richtung mit einer Kraft beaufschlagt. Das Federglied 32 des Ausführungsbeispiels ist eine Schraubenfeder und wirkt als Druckfeder. Das Federglied 32 stützt sich in die proximale Richtung an dem Gehäuseabschnitt 3 ab. Das Federglied 32 stützt sich in die distale Richtung an einer ringförmigen Gleitscheibe 33 ab, die zwischen das Kupplungsglied 16 und das Dosier- und Anzeigeglied 30 eingelegt ist und sich ihrerseits an dem Eingriffselement 31 abstützt. Mittels der Gleitscheibe 33 wird das Federglied 32 weitestgehend von Drehbewegungen des Dosier- und Anzeigeglieds 30 entkoppelt.Finally, the metering and advancing device comprises a
Das Dosier- und Anzeigeglied 30 ist relativ zu dem Kolben 10 und der Kolbenstange 11 sowie im Übrigen zu den Kupplungsgliedern 12, 16 und 22 zwischen axialen Endpositionen hin und her beweglich. Die beiden Endpositionen sind eine Nulldosis-Position und eine Maximaldosis-Position. Die beiden Endpositionen werden je durch einen Anschlag vorgegeben. Den Anschlag für die Nulldosis-Position bildet eine Schulter 2c an dem distalen Ende des Gehäuseabschnitts 2 als Axialanschlag. Den Anschlag für die Maximaldosis-Position bildet der Gehäuseabschnitt 3. In der Nulldosis-Position überlappt ein distaler Abschnitt des Dosier- und Anzeigeglieds 30 das Reservoir R in die Vortriebsrichtung V bis über den Kolben 10 hinaus, wenn der Kolben 10 wie in den
Das Dosier- und Anzeigeglied 30 ist an seinem distalen Ende nicht umlaufend vollzylindrisch, sondern nur teilzylindrisch, um trotz der axialen Überlappung den Blick auf den Kolben auch dann freizugeben, wenn das Dosier- und Anzeigeglied 30 wie bevorzugt nicht aus einem durchsichtigen Kunststoffmaterial, sondern aus einem undurchsichtigen oder allenfalls opaken Kunststoffmaterial oder einem anderen Material geformt ist. Der distale Rand des Dosier- und Anzeigeglieds 30 verläuft spiralförmig um die Achse RT, so dass das Dosier- und Anzeigeglied 30 wie in den
Das Dosier- und Anzeigeglied 30 ist Träger einer Dosisskala, die an dem äußeren Umfang des Dosier- und Anzeigeglieds 30 spiralig umläuft mit einer in Bezug auf die Achse RT gemessenen Steigung, die der Steigung des Gewindes 30a entspricht. Die Dosisskala besteht aus Markierungen und Ziffern, wobei jede der Markierungen einer kleinsten einstellbaren Dosiseinheit entspricht. Die Dosisskala ist während der Einstellung der zu verabreichenden Dosis durch das Fenster 4 des Gehäuseabschnitts 3 ablesbar (
Der Betätigungsknopf 27 bildet das proximale Ende der Injektionsvorrichtung. Er ist mit dem Gehäuseabschnitt 3 verclippt, indem der Gehäuseabschnitt 3 an seinem proximalen Ende mit einer Schulter 5 versehen ist, die der Betätigungsknopf 27 hintergreift. Der Betätigungsknopf 27 ist relativ zu dem Gehäuse 1-3 um die Achse RT in eine Dosierrichtung und eine Korrekturrichtung drehbar. Bei dem Einstellen der Dosis wird durch die Drehung des Betätigungsknopfs 27 in die Dosierrichtung die Dosis vergrößert und bei einer Drehbewegung in die Korrekturrichtung verringert, wodurch eine versehentlich zu groß eingestellte Dosis korrigiert werden kann. Der Betätigungsknopf 27 ist ferner mit dem Kupplungsglied 22 axial beweglich, aber mittels der Eingriffselemente 25 verdrehgesichert verbunden.The
Die
Der Betätigungsknopf 27 bildet über die Verdrehsicherung mit dem Kupplungsglied 22 hinaus eine Rutschkupplung, im Ausführungsbeispiel eine Drehrutschkupplung, mit dem Gehäuseabschnitt 3. An dem Betätigungsknopf 27 sind für die Bildung der Rutschkupplung um die Achse RT gleichmäßig verteilt mehrere Rastelemente 28 geformt, die mit korrespondierenden an dem distalen Ende des Gehäuseabschnitts 3 geformten, vorzugsweise kongruenten Rastgegenelementen 8 in einem Kupplungseingriff sind. Die Anzahl der Rastgegenelemente 8 ist geringer als die Anzahl der Rastelemente 28. Der Betätigungsknopf 27 ist bei bestehendem Kupplungseingriff der Rastelemente 28 und Rastgegenelemente 8 relativ zu dem Gehäuseabschnitt 3 um die Achse RT drehbar, wobei die Rastelemente 28 und Rastgegenelemente 8 in diskret über den Umfang verteilten Rastpositionen paarweise lösbar miteinander verrasten. Die Teilung der Rastelemente 28 und somit der im Winkel- oder Bogenmaß zwischen je in Umfangsrichtung nächstbenachbarten Rastelementen 28 gemessene Abstand korrespondiert mit der kleinsten einstellbaren Dosiseinheit, die Teilung der Rastgegenelemente einem ganzzahligen Vielfachen derselben Dosiseinheit. Die Rutschkupplung muss nicht unbedingt zwischen dem Gehäuse 1-3 und dem Betätigungsknopf 27 unmittelbar gebildet sein. Anstatt die Rastelemente 28 an dem Betätigungsknopf 27 vorzusehen, könnten sie auch an dem Kupplungsglied 22 geformt sein. Modifizierte Rastelemente und Rastgegenelemente könnten in beiden Ausführungen beispielsweise axial anstatt radial ineinander greifen.The operating
Die Rastelemente 28 und entsprechend die Rastgegenelemente 8 sind bezüglich der Drehrichtung asymmetrisch geformt, so dass die für das Lösen des Rasteingriffs in eine Kupplungsdosierrichtung aufzuwendende Kraft größer ist als in die Gegendrehrichtung, die Kupplungskorrekturrichtung. Da im Ausführungsbeispiel der Betätigungsknopf 27 die Rastelemente 28 unmittelbar selbst bildet, ist die Dosierrichtung des Betätigungsknopfs 27 gleichzeitig auch die Kupplungsdosierrichtung, und die Korrekturrichtung ist die Kupplungskorrekturrichtung. Die Rastgegenelemente 8 sind Rastnocken, die von der Mantelaußenfläche des Gehäuseabschnitts 3 nach radial auswärts vorragen. Die Rastelemente 28 sind entsprechend an der zugewandt gegenüberliegenden Mantelinnenfläche des Betätigungsknopfs 27 als korrespondierende Vertiefungen oder Zahnlücken einer Innenverzahnung gebildet. Um die Asymmetrie bezüglich der beiden Drehrichtungen zu erzielen, sind die in Kupplungsdosierrichtung weisenden, vorlaufenden Flanken der Rastelemente 28 flacher als die in die Gegendrehrichtung weisenden, bei Bewegung der Rastelemente 28 in die Kupplungsdosierrichtung nachlaufenden Flanken. Die Rastgegenelemente 8 sind korrespondierend mit beiden Flanken angeschmiegt geformt.The latching
Die Asymmetrie der Rutschkupplung in Bezug auf die beiden Drehrichtungen des Betätigungsknopfs 27 ist auf die Richtung der von dem Kraftglied 32 auf das Dosier- und Anzeigeglied 30 ausgeübten Kraft abgestimmt. Bei einer Drehbewegung des Betätigungsknopfs 27 in Richtung einer Vergrößerung der Dosis, dem Aufdosieren, wird nämlich über die bei 20, 24 gebildete Dosierkupplung und den bei 18 und 31 gebildeten Führungseingriff das Dosier- und Anzeigeglied 30 im Gewindeeingriff verdreht und in die proximale Richtung bewegt. Im Verlaufe der Translation in die proximale Richtung wird das Federglied 32 zunehmend gespannt. Die Elastizitätskraft des Federglieds 32 setzt der Bewegung des Dosier- und Anzeigeglieds 30 in die proximale Richtung einen Widerstand entgegen, der über die beschriebene Kopplung auf die Rutschkupplung 8, 28 wirkt und der Drehbewegung des Betätigungsknopfs 27 in die Dosierrichtung, in welche die flacheren Flanken der Rastelemente 28 und Rastgegenelemente 8 weisen, einen zusätzlichen, beim Aufdosieren zunehmenden Reibwiderstand entgegensetzt. Die von dem Federglied 32 ausgeübte Kraft unterstützt umgekehrt die Drehbewegung in Richtung einer Dosiskorrektur.The asymmetry of the slip clutch with respect to the two directions of rotation of the operating
Der Betätigungsknopf 27 ist topfförmig mit einem das distale Ende der Injektionsvorrichtung bildenden Boden und einer von dem Boden aufragenden, um die Achse RT umlaufenden Wand, an deren Innenfläche die Rastelemente 8 über den Umfang gleichmäßig verteilt angeordnet und je als axial erstreckte Vertiefung geformt sind. Die Rastelemente 28 sind im montierten Zustand sowohl mit den Rastgegenelementen 8 als auch mit den Eingriffselementen 25 (
Die Dosier- und Vortriebseinrichtung enthält über die von den Kupplungsgliedern 16 und 22 gebildete Dosierkupplung hinaus eine zweite Kupplung, nämlich die bereits ebenfalls genannte Ausschüttkupplung, die in
Das Kupplungsglied 16 ist wahlweise mit dem Kupplungsglied 22 oder dem Kupplungsglied 12 in einem Kupplungseingriff, d. h. bei gelöster Ausschüttkupplung im Kupplungseingriff mit dem Kupplungsglied 22 und bei gelöster Dosierkupplung im Kupplungseingriff mit dem Kupplungsglied 12. Für die Einstellung der Dosis ist die Dosierkupplung geschlossen, d. h. die Eingriffselemente 15a und 15b sind in axialer Überdeckung nur mit dem Kupplungsglied 22, dessen Mantelinnenfläche jedoch umlaufend glatt ist, so dass bei der Einstellung der Dosis das Kupplungsglied 22 relativ zu dem Kupplungsglied 12 drehen kann. Für die Ausschüttung der eingestellten Dosis wird das Kupplungslied 12 in den Kupplungseingriff mit dem Dosier- und Anzeigeglied 16 bewegt, die Dosierkupplung wird dadurch gelöst und die Ausschüttungskupplung geschlossen, so dass die Ausschüttung beginnen kann.
Der Benutzer hält die Injektionsvorrichtung in einer Hand und setzt mit der anderen Hand eine Kanüleneinheit auf den Auslass 1a auf und schraubt sie fest. Ansonsten befindet sich die Injektionsvorrichtung in dem in den
Die Kolbenstange 11 ist von der Dosierbewegung, im Ausführungsbeispiel Dosierdrehbewegung, entkoppelt und wird zusätzlich durch das umgebende, ebenfalls entkoppelte Kupplungsglied 12 gegen Drehbewegungen gesichert. Die Sicherung wird wie bereits erwähnt durch die zwischen dem Kupplungsglied 12 und der Halteeinrichtung 2a gebildete Rutschkupplung und den verdrehgesicherten Eingriff des Kupplungsglieds 12 mit der Kolbenstange 11 erhalten.The
Wenn die gewünschte Dosis eingestellt ist, sticht der Benutzer die Einstechkanüle an der gewünschten Injektionsstelle in und unter die Haut in das subkutane Gewebe. Anschließend löst er mit der gleichen Hand, die auch die Injektionsvorrichtung bei dem Einstechen hält, die Ausschüttung der eingestellten Dosis aus.When the desired dose is adjusted, the user pricks the puncture cannula into and under the skin into the subcutaneous tissue at the desired injection site. He then releases the release of the adjusted dose with the same hand, which also holds the injection device during insertion.
Der Betätigungsknopf 27, der bei der Einstellung der Dosis die Funktion eines Dosierknopfs erfüllt, ist in Doppelfunktion auch Auslöseknopf. Während der Einstellung der Dosis wird das Dosier- und Anzeigeglied 30 entsprechend den Dosisrastpositionen der Rastelemente 28 und Rastgegenelemente 8 der Rutschkupplung gehalten, d. h. die Rutschkupplung verhindert, dass sich das Dosier- und Anzeigeglied 30 unter der Einwirkung des Federglieds 32 bewegen kann. Für die Ausschüttung muss daher die über die Rutschkupplung bei 8, 28 bestehende Kopplung zwischen dem Gehäuseabschnitt 3 und dem Dosier- und Anzeigeglied 30 gelöst werden. Dies geschieht durch Lösen der bei 20, 24 gebildeten Dosierkupplung, indem der Benutzer den Betätigungsknopf 27 mit dem Daumen in die distale Richtung presst. Bei Ausübung einer entsprechenden Druckkraft bewegt sich der Betätigungsknopf 27 relativ zu dem Gehäuseabschnitt 3 und dem Kupplungsglied 22 entgegen der Kraft der Feder 23 in die distale Richtung und drückt bei dieser Bewegung gegen das Kupplungsglied 12. Das Kupplungsglied 12 federt im Bereich seiner integrierten Feder 13 axial in sich ein, so dass seine Eingriffselemente 15a in den verdrehgesicherten Eingriff mit den Eingriffsgegenelementen 21 des Kupplungsglieds 16 gelangen. In einer Übergangsphase der Axialbewegung ist die Dosierkupplung zwischen dem Kupplungsglied 22 und dem Kupplungsglied 16 noch geschlossen, während auch bereits der Kupplungseingriff der Ausschüttkupplung zwischen dem Kupplungsglied 12 und dem Kupplungsglied 16 hergestellt ist. Sobald die Eingriffselemente 15b jedoch den Axialanschlag des Kupplungsglieds 12 in die distale Richtung kontaktieren, bewirkt anhaltender Druck auf den Betätigungsknopf 27, dass das Kupplungsglied 16 gegen die Kraft seiner Feder 17 in die distale Richtung bewegt und dadurch axial aus dem Kupplungseingriff mit dem Kupplungsglied 22 gehoben wird.The
Sobald die Dosierkupplung gelöst ist, schraubt sich das Dosier- und Anzeigeglied 30 unter der Elastizitätskraft des Federglieds 32 in die distale Richtung. Der Drehbewegungsanteil des Dosier- und Anzeigeglieds 30 wird im Führungseingriff zwischen der Führung 18 und dem Eingriffsglied 31 auf das Kupplungsglied 16 übertragen. Das Kupplungsglied 16 überträgt wegen der geschlossenen Ausschüttkupplung die Drehbewegung auf das Kupplungsglied 12, das wiederum verdrehgesichert mit der Kolbenstange 11 verbunden ist, so dass sich die Kolbenstange 11 im Gewindeeingriff mit der Halteeinrichtung 2a dreht und den Kolben 10 in die Vortriebsrichtung V schiebt. Die Ausschüttbewegung der daran beteiligten Komponenten wird durch Anschlag des Dosier- und Anzeigeglieds 30 an der Schulter 2c beendet. Der Hub oder axiale Anteil des Verstellwegs des Dosier- und Anzeigeglieds 30 bestimmt daher den Hub des Kolbens 10 und somit die ausgeschüttete Dosis. Wegen der größeren Gewindesteigung der Gewinde 3a und 30a gegenüber den Gewinden der Kolbenstange 11 und der Halteeinrichtung 2a wird der Hub des Dosier- und Anzeigeglieds 30 in einen dem Untersetzungsverhältnis entsprechenden Hub des Kolbens 10 untersetzt. Während der Ausschüttbewegung erzeugt die zwischen der Feder 14 und der Halteeinrichtung 2a gebildete Rutschkupplung ein Klickgeräusch, das deutlich wahrnehmbar ist und dem Benutzer auch akustisch anzeigt, dass Medikament ausgeschüttet wird. Der Ausschüttvorgang ist ferner durch die Fenster 1b und 2b anhand der axialen Position des Kolbens 10 zumindest grundsätzlich verifizierbar.Once the Dosierkupplung is solved, the metering and
Bei dem Einstellen der Dosis wird das Stoppglied 26 im Gewindeeingriff mit dem Kupplungsglied 22 entsprechend der eingestellten Dosis ebenfalls bewegt. Wenn die durch den maximalen Hub des Stoppglieds 26 vorgegebene Medikamentenmenge insgesamt verabreicht wurde, was bei vollständig gefülltem Reservoir R erst nach mehreren Injektionen der Fall ist, tauscht der Benutzer das entleerte Reservoir R gegen ein gefüllte neues Reservoir R aus. Er muss hierfür lediglich den Gehäuseabschnitt 1 von dem proximalen Gehäuseabschnitt 2, 3 trennen, das neue Reservoir R mit bereits darin aufgenommenem Kolben 10 einsetzen und die Gehäuseabschnitt 1 und 2, 3 wieder miteinander verbinden.In adjusting the dose, the
Im Ausführungsbeispiel sind mit Ausnahme des Kraftglieds 32 sämtliche Federn als integrierter Bestandteil jeweils eines Kupplungsglieds mit Kopplungsteil und Federteil gebildet. Eine oder mehrere der Federn kann alternativ jedoch auch in herkömmlicher Weise als Stahlfeder separat vom jeweiligen Kupplungsglied gebildet sein. So können die Federn 13, 17 und 23 ohne weiteres durch Stahlfedern ersetzt werden, da sie ausschließlich die Federfunktion erfüllen. Für den Ersatz der Feder 14 hingegen bedarf es einer Ersatzfeder und der Formung von Rastelementen am distalen Ende des Kupplungsglieds 12.In the exemplary embodiment, with the exception of the
Zu der Anordnung aus Dosier- und Anzeigeglied 30 und Federglied 32 ist zu bemerken, dass anstatt des Dosier- und Anzeigeglieds 30 alternativ das Federglied 32 in axialer Überlappung mit dem Reservoir R angeordnet sein kann und sich an einem Widerlager, beispielsweise der Schulter 2c, abstützt. Bei einer derartigen Umkehrung der Einbauverhältnisse würde das Dosier- und Anzeigeglied 30 bei der Ausschüttung in die proximale Richtung bis gegen einen Anschlag bewegt werden. In noch einer weiteren Alternative kann das Federglied 32 als Zugfeder eingebaut sein, obgleich der Einbau als Druckfeder besonderes bevorzugt ist. Noch eine weitere Alternative wird in den deutschen Patentanmeldungen Nrn.
- 11
- Gehäuseabschnitthousing section
- 1a1a
- Auslassoutlet
- 1b1b
- Fensterwindow
- 22
- Gehäuseabschnitthousing section
- 2a2a
- Halteeinrichtungholder
- 2b2 B
- Fensterwindow
- 2c2c
- Schultershoulder
- 33
- Gehäuseabschnitthousing section
- 3a3a
- Gewindethread
- 44
- Fensterwindow
- 55
- Schultershoulder
- 66
- Innere HülseInner sleeve
- 77
- Führungguide
- 88th
- RastgegenelementDetent counter element
- 99
- Kupplungsfederclutch spring
- 1010
- Kolbenpiston
- 1111
- Kolbenstangepiston rod
- 1212
- Kupplungsgliedcoupling member
- 1313
- Federfeather
- 1414
- Federfeather
- 15a15a
- Eingriffselementengaging member
- 15b15b
- Eingriffselementengaging member
- 1616
- Kupplungsgliedcoupling member
- 1717
- Federfeather
- 1818
- Kopplungsteil, FührungCoupling part, guide
- 1919
- Anschlagattack
- 2020
- Eingriffselementengaging member
- 2121
- Eingriffsgegenelement, FührungIntervention counter element, guide
- 2222
- Kupplungsgliedcoupling member
- 22a22a
- Gewindethread
- 2323
- Federfeather
- 2424
- EingriffsgegenelementInfringing element
- 2525
- Eingriffselementengaging member
- 2626
- Stoppgliedstop member
- 2727
- Betätigungsknopfactuating button
- 2828
- Rastelementlocking element
- 2929
- --
- 3030
- Dosier- und AnzeigegliedDosing and display element
- 30a30a
- Gewindethread
- 3131
- Eingriffselementengaging member
- 3232
- Federgliedspring member
- 3333
- Gleitscheibesliding disk
- RR
- Reservoirreservoir
- RTRT
- Längsachselongitudinal axis
- VV
- Vortriebsrichtungdrive direction
Claims (28)
- Injection device comprising:a) a housing (1-3) with a reservoir (R) for an injectable product,b) an actuation knob (27) which, for the setting of a product dose can be moved relative to the housing (1-3) in a direction, which increases the dose and in a direction providing a correction of the dose,c) a delivery element (10) for the emptying of the set dose,d) a slipping clutch (3, 27) with a detent element (28) and a counter detent element (8), which come into mutual positive and non-positive engagement in discrete latching positions of the housing (1-3) to arrest the actuating head (27) during a movement in the dosing direction or in the correction direction.e) and a spring element (32), which applies a spring force opposing the movement of the actuating head (27) in at least one of the directions,f) characterised in that the detent element (28) and the counter detent element (8) are formed in such a way, that in the latching engagement of the motion they at least apply a lower resistance to the motion in one of the directions than in the other.
- Injection device according to claim 1, in which the spring element (32) is coupled with, or can be coupled with the delivery element (10) and drives the spring element (32) during the emptying.
- Injection device according to the foregoing claim, in which the spring element (32) is uncoupled from the delivery element (10) during the setting of the dose and can be coupled with the delivery element (10) for the emptying by means of an emptying coupling (12, 16).
- Injection device according to one of the foregoing claims, in which during the movement of the actuating knob (27) the spring element (32) is more strongly tensioned in at least one of the directions from latched position to latched position.
- Injection device according to one of the foregoing claims, in which the spring force of the spring element (32) opposes the movement in the direction of dosing.
- Injection device according to one of the foregoing claims, in which the spring element (32) is a compression spring or a torsion spring.
- Injection device according to one of the foregoing claims, in which the slipping clutch comprises a first clutch half (27) with the detent element (28) and a second clutch half (3) with the counter detent element (8) and one of the clutch halves (3, 27) can be rotated relative to the other about an axis of rotation (RT).
- Injection device according to claim 7, in which the detent element (28) and the counter detent element (8) come into radial meshing engagement with each other with respect to the axis of rotation (RT).
- Injection device according to claim 7, in which the detent element and the counter detent element come into axial meshing engagement with respect to the axis of rotation (RT).
- Injection device according to one of the foregoing claims, in which the slipping clutch comprises a first clutch half (27) with the detent element (28) and a second clutch half (3) with the counter detent element (8) and the detent element (28) and the counter detent element (8) are in direct meshing engagement with each other.
- Injection device according to one of the four last foregoing claims, in which one of the clutch halves (3, 27) can move relative to the other in the dosing device and relative to the correction direction.
- Injection device according to one of the foregoing claims, in which the detent element (28) and/or the counter detent element (8) is/are formed asymmetrically with respect to the dosing device.
- Injection device according to one of the foregoing claims, in which the slipping clutch comprises a clutch spring (9) in addition to the spring element (32) and the clutch spring (9) opposes a freeing of the meshing engagement by means of a resetting spring force.
- Injection device according to claim 13, in which the slipping clutch comprises a first clutch half (3) with the detent element (28) and a second clutch half (27) with the counter detent element (8) and on at least one of the clutch halves (3, 27) the clutch spring (9), and on the clutch spring (9) either the detent element (28) or the counter detent element (8) is formed or fixed.
- Injection device according to claim 14, in which one of the clutch halves (3, 27) can rotate relative to the other half about an axis of rotation (RT) and the clutch spring (9) is an elastic, preferably radial, spiral spring.
- Injection device according to claim 15, in which the clutch spring (9) takes the form of a spiral spring on at least one of the clutch halves (3, 27) and is rigidly fixed to both in acting as a spiral spring.
- Injection device according to one of the foregoing claims, in which a number of detent elements (28) or counter detent elements (8) are provided and preferably a clutch spring (9) per detent element (28) or counter detent element (8).
- Injection device according to one of the five last foregoing claims, in which at least one of the clutch halves (3, 27) comprises a ring or part ring with ring segments arranged one behind the other in the circumferential direction, of which one forms the clutch spring (9) and the other an opposite stiffer ring element.
- Injection device according to claim 18, in which the ring or part ring comprises elastic first ring segments and opposite stiffer second ring segments arranged alternately one behind the other and the first ring segments each form a clutch spring (9).
- Injection device according to one of the foregoing claims, in which the slipping clutch (3, 27) comprises a number of detent elements (28) or a number of counter detent elements (8), which in engagement with one another can move relative to one another in a clutch dosing direction, in which the dose is increased and also in an opposite clutch dosing correction direction.
- Injection device according to one of the foregoing claims, in which the actuation knob (27) for the setting of the dose is coupled with a dosing element (30) and the dosing element (30) can move during the emptying of the dose up to an emptying stop (2c) and for the setting of the dose away from the emptying stop (2c) against the spring force of the spring element (32).
- Injection device according to claim 21, in which the actuation knob (27) and the dosing element (30) are detachably coupled together by means of a dosing clutch (16, 22).
- Injection device according to claim 21 or claim 22, in which the dosing element (30) is uncoupled from the delivery element (10) for the setting of the dose and can be coupled with the delivery element (10) for the emptying by means of an emptying clutch (12, 16).
- Injection device according to one of the foregoing claims, in which the detent element (28) is formed on or fixed to the actuating knob (27).
- Injection device according to one of the foregoing claims, in which the counter detent element (8) is formed on or fixed to the housing (1-3).
- Injection device according to one of the claims 1 24, in which the counter detent element is formed on or fixed to an element, which is guided to move axially relative to the housing while being prevented from twisting and on which the spring element is supported.
- Injection device according to one of the foregoing claims, in which the actuating knob (27) can move in a rotary sense relative to the housing (1-3) for the setting of the dose.
- Injection device according to one of the foregoing claims, in which the actuating knob (27) can describe a translatory motion relative to the housing (1-3), preferably in a distal direction, as a tripping device for the emptying.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL06775147T PL1926514T3 (en) | 2005-09-14 | 2006-08-22 | Injection device with two-way slip clutch |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005043806 | 2005-09-14 | ||
DE102005060929A DE102005060929A1 (en) | 2005-09-14 | 2005-12-20 | Product e.g. insulin, injecting device, has housing and operating knob with locking units that are formed such that movement of operating knob in one direction has smaller resistance in contrast to movement in other direction |
PCT/CH2006/000453 WO2007030957A1 (en) | 2005-09-14 | 2006-08-22 | Injection device with two-way slip clutch |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1926514A1 EP1926514A1 (en) | 2008-06-04 |
EP1926514B1 true EP1926514B1 (en) | 2008-12-03 |
Family
ID=37106515
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06775147A Active EP1926514B1 (en) | 2005-09-14 | 2006-08-22 | Injection device with two-way slip clutch |
Country Status (10)
Country | Link |
---|---|
US (1) | US7955303B2 (en) |
EP (1) | EP1926514B1 (en) |
JP (1) | JP4681055B2 (en) |
CN (1) | CN101262899B (en) |
AT (1) | ATE415991T1 (en) |
AU (1) | AU2006291940B2 (en) |
DE (2) | DE102005060929A1 (en) |
DK (1) | DK1926514T3 (en) |
PL (1) | PL1926514T3 (en) |
WO (1) | WO2007030957A1 (en) |
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WO2016198701A2 (en) | 2015-10-15 | 2016-12-15 | Copernicus Sp. Z O.O. | A setting mechanism |
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EP2644218B1 (en) | 2012-03-30 | 2019-10-09 | Tecpharma Licensing AG | Injection device with dose display and clockwork drive |
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-
2005
- 2005-12-20 DE DE102005060929A patent/DE102005060929A1/en not_active Withdrawn
-
2006
- 2006-08-22 DE DE502006002279T patent/DE502006002279D1/en active Active
- 2006-08-22 EP EP06775147A patent/EP1926514B1/en active Active
- 2006-08-22 PL PL06775147T patent/PL1926514T3/en unknown
- 2006-08-22 DK DK06775147T patent/DK1926514T3/en active
- 2006-08-22 AU AU2006291940A patent/AU2006291940B2/en active Active
- 2006-08-22 CN CN2006800335865A patent/CN101262899B/en active Active
- 2006-08-22 AT AT06775147T patent/ATE415991T1/en active
- 2006-08-22 WO PCT/CH2006/000453 patent/WO2007030957A1/en active Application Filing
- 2006-08-22 JP JP2008530290A patent/JP4681055B2/en active Active
-
2008
- 2008-03-12 US US12/047,043 patent/US7955303B2/en active Active
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2644218B1 (en) | 2012-03-30 | 2019-10-09 | Tecpharma Licensing AG | Injection device with dose display and clockwork drive |
WO2016055624A2 (en) | 2014-10-09 | 2016-04-14 | Sanofi | Drive mechanism and drug delivery device herewith |
WO2016055629A1 (en) | 2014-10-09 | 2016-04-14 | Sanofi | Automatic drug injection device with torsion drive spring and rotational dose setting and correction mechanism |
WO2016198701A2 (en) | 2015-10-15 | 2016-12-15 | Copernicus Sp. Z O.O. | A setting mechanism |
WO2017064275A1 (en) | 2015-10-15 | 2017-04-20 | Copernicus Sp. Z O.O. | A setting mechanism for a dosing device |
Also Published As
Publication number | Publication date |
---|---|
US20080306445A1 (en) | 2008-12-11 |
CN101262899B (en) | 2011-04-20 |
JP2009507581A (en) | 2009-02-26 |
ATE415991T1 (en) | 2008-12-15 |
PL1926514T3 (en) | 2009-06-30 |
CN101262899A (en) | 2008-09-10 |
AU2006291940B2 (en) | 2009-04-23 |
US7955303B2 (en) | 2011-06-07 |
DK1926514T3 (en) | 2009-04-06 |
AU2006291940A1 (en) | 2007-03-22 |
JP4681055B2 (en) | 2011-05-11 |
DE102005060929A1 (en) | 2007-03-15 |
WO2007030957A1 (en) | 2007-03-22 |
EP1926514A1 (en) | 2008-06-04 |
DE502006002279D1 (en) | 2009-01-15 |
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