EP1893123A1 - Method for packing a predetermined liquid substance dose in a straw and device for carrying out said method - Google Patents

Method for packing a predetermined liquid substance dose in a straw and device for carrying out said method

Info

Publication number
EP1893123A1
EP1893123A1 EP06764781A EP06764781A EP1893123A1 EP 1893123 A1 EP1893123 A1 EP 1893123A1 EP 06764781 A EP06764781 A EP 06764781A EP 06764781 A EP06764781 A EP 06764781A EP 1893123 A1 EP1893123 A1 EP 1893123A1
Authority
EP
European Patent Office
Prior art keywords
accessory
pipette tip
holder
receptacle
straw
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP06764781A
Other languages
German (de)
French (fr)
Other versions
EP1893123B1 (en
Inventor
Alain Ehrsam
Christian Beau
Laurent Cohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cryo Bio System SAS
Original Assignee
Cryo Bio System SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cryo Bio System SAS filed Critical Cryo Bio System SAS
Publication of EP1893123A1 publication Critical patent/EP1893123A1/en
Application granted granted Critical
Publication of EP1893123B1 publication Critical patent/EP1893123B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A61D19/022—Containers for animal semen, e.g. pouches or vials ; Methods or apparatus for treating or handling animal semen containers, e.g. filling or closing

Definitions

  • the present invention relates to the conditioning of predetermined doses of liquid substance in flakes.
  • flakes are conditioning units formed of a thin plastic tube whose inner diameter is in particular sufficiently small to allow the retention in place of the dose of liquid substance by capillarity and a plug engaged in the thin tube near one end, having two porous pads and, between these two buffers, a volume of gelling powder, that is to say, turning into gel in contact with an aqueous liquid.
  • a packaging method comprising a filling step for penetrating a predetermined dose of liquid substance, initially contained in an open receptacle on the top, into the thin tube of the invention is already known, in particular from the European Patent Application 0 480 109.
  • a straw This step is effected by sealingly fitting a filling accessory in a first end of the thin tube of the straw while the second end of this thin tube is connected to a vacuum source, with the straw which is in a supine position, and with a conduit of the filling accessory which is immersed in the liquid substance contained in the receptacle.
  • the depression generated in the straw by the vacuum source causes the flow of liquid substance from the receptacle to the straw, via the filling accessory.
  • European Patent Application 0 856 298 discloses an improved version of the filling accessory.
  • a machine on which the accessory and the receptacle are mounted manually respectively on an accessory holder and on a receptacle-holder of a moving carriage performing coordinated back and forth movements. with the transverse displacement of a carpet carrying the flakes to fill so as to engage and then disengage the filling accessory in and out of a flake of the carpet, then in the next straw and so on with the sequins sequants.
  • the invention aims to further automate the filling of straws in a simple, convenient and economical way.
  • a method for conditioning in a straw a predetermined dose of liquid substance initially contained in a receptacle open on the top comprising a filling step for causing said predetermined dose to penetrate into said straw, arranged in a lying position, with a filling device fitted into said straw, which method comprises, prior to the filling step: the step of cooperating a pipette tip, in a standing position, with said receptacle to collect at least a said dose of liquid substance; the step of obtaining an said accessory having a body adapted to cooperate with said pipette tip, in a standing position, and having a capillary channel nozzle adapted to be fitted into said straw, which nozzle is oriented transversely to said body so that when said body is in a standing position said beak is in a supine position; and the step of cooperating said pipette tip, in a standing position, containing at least said dose, with said body so that the contents of said pipette tip belong to this accessory
  • the capillary nature of the channel in the spout allows the content of the accessory, from the pipette tip, to remain in the the accessory as long as the source of vacuum has not generated in the straw the depression producing the flow of the liquid substance.
  • the method further comprises, prior to the filling step:
  • the method comprises prior to the step of cooperating said pipette tip with said receptacle:
  • the step of fitting said pipette tip into a pipette; while the step of cooperating said pipette tip with said receptacle comprises: - the step of disposing said pipette provided with said pipette tip above said receptacle;
  • the step of cooperating said pipette tip containing at least said dose with said accessory comprises: the step of disposing said pipette tip containing at least said dose over said accessory;
  • the method comprises, prior to said steps automatically carried out:
  • a accessory rack is selected as an accessory box
  • a tip rack is selected as a spike holder
  • a receptacle rack is selected as a receptacle holder;
  • a receptacle carousel is selected as a receptacle holder; and or
  • the process comprises, prior to the filling step: the step of moving said accessory from said accessory box to the top of an accessory holder;
  • the step of moving said accessory comprises:
  • the step of sliding said accessory comprises the step of moving a plunger pressed against said accessory.
  • the invention also aims, in a second aspect, a device suitable for implementing the method set out above, this device comprising an accessory adapted to be fitted into a straw in the prone position to introduce a predetermined dose of liquid substance initially contained in a receptacle open on the top, characterized in that said accessory has a body adapted to cooperate with a standing pipette tip so that the contents of said pipette tip belong to this accessory, and has a channel nozzle capillary adapted to be fitted into said straw, oriented transversely to said body so that when said body is in a standing position said nozzle is in the supine position.
  • Said body comprises a bottom wall
  • Said bottom wall is inclined at an angle of between 25 ° and 35 ° with respect to said spout; Said bottom wall is inclined at an angle of between 2.5 ° and 6.5 ° with respect to said spout;
  • Said nozzle comprises said capillary channel over its entire length
  • Said body comprises a bottom wall and said capillary channel extends from an outlet orifice to a passage which communicates with a space delimited by said body and said bottom wall;
  • Said nozzle comprises a cylindrical portion and a frustoconical portion
  • Said nozzle comprises a cylindrical portion and a frustoconical pellet attached to said cylindrical portion;
  • Said body comprises a bottom wall and a tubular wall subdivided into a first tubular portion and a second tubular portion by said bottom wall;
  • Said first portion and said bottom wall define a reservoir for containing said liquid substance while said second tubular portion forms a base on which abuts said accessory;
  • Said body comprises a bottom wall and a frustoconical wall extending from an inlet opening to said bottom wall;
  • Said accessory has a rib opposite said nose
  • Said accessory has two tabs opposite one another on said body;
  • Said accessory comprises two tabs on either side of each of said tabs;
  • Said accessory comprises two notches bordering an inlet opening above said tongues;
  • Said device comprises, in addition to the accessory, a clamp having a central body and two elastically deformable arms connected to said central body having in their distal portion a hook adapted to engage or disengage said respective tongue of said accessory by deformation elastic of said arms; Said arms comprise a section disposed between said central body and said hook;
  • Said hook has a convex surface against which said tongue presses to elastically constrain said arms;
  • said accessory comprises two notches bordering an inlet opening and each arm has, at the junction between said section and said hook, a shoulder adapted to be housed in said respective notch of said accessory when said hooks are engaged in said tabs;
  • Said device comprises, in addition to the accessory, an accessory holder comprising a base on which said accessory rests when it rests on said accessory-holder and lugs against which said accessory abuts when said accessory is in a abutment position, said protruding beak beyond said tabs;
  • said tabs have a recess arcuate against which abuts said accessory in said stop position;
  • Said tabs are separated by a frustoconical groove in which said accessory fits;
  • Said accessory has two tabs opposite each other on said body and two tabs on either side of each of said tabs and said tabs of said accessory holder have on the opposite side to said frustoconical groove a rim; protruding under which is housed a said tab of said accessory when said accessory is in said abutment position;
  • Said device comprises, in addition to the accessory, a pusher comprising a presser and a jack comprising a rod and a body, said presser being able to bear against said accessory so that the accessory slides from a first position to a second position;
  • Said presser has a recess in an arc to come into contact with said accessory;
  • Said accessory has a rib opposite said spout and said presser and said rib have an arrangement adapted for said rib to be housed under the lower surface of said presser when said presser comes into contact with said accessory; and or Said accessory has a capillary channel nozzle formed of a single rigid block adapted to be fitted into said straw.
  • Said nozzle comprises a frustoconical portion and a cylindrical portion
  • Said beak comprises a capillary channel
  • FIGS. 1 and 2 are two perspective views taken from two angles different in isolation presenting a filling accessory according to the invention;
  • Figures 3, 4 and 5 show this accessory respectively in an elevational view taken from the side that is seen on the left in Figure 1, a top plan view and an elevational sectional view as shown in V-V on Figure 3;
  • - Figure 6 is a view similar to Figure 5 illustrating a variant of this accessory in which the bottom wall is slightly inclined;
  • Figures 7 and 8 are respectively a perspective view and an elevational view of a gripper for gripping the accessory;
  • Figure 9 is a perspective view of this clamp and an accessory that it captures;
  • FIGS. 1 and 2 are two perspective views taken from two angles different in isolation presenting a filling accessory according to the invention;
  • Figures 3, 4 and 5 show this accessory respectively in an elevational view taken from the side that is seen on the left in Figure 1, a top plan view and an elevational sectional view as shown in V-V on Figure 3;
  • - Figure 6 is a view
  • FIG. 10 is a perspective view illustrating the clamp, an accessory holder, a pusher and the accessory in a removal position on the accessory holder
  • Figure 14 is a perspective view showing separately the accessory holder
  • FIG. 15 is a top plan view of the accessory, the accessory carrier and the pusher as seen in FIG. 13 but where the clip, although present, is not illustrated for the sake of clarity.
  • Figure 16 is a view similar to Figure 15 but where the accessory is pressed by the pusher against the accessory holder in its abutment position;
  • Figure 17 is an elevational view taken from the side shown below in Figure 16;
  • Figures 18 and 19 are respectively a perspective view and an elevational view of the clamp engaged in a clip holder;
  • Figures 20 and 21 are respectively a perspective view and an elevational view taken from the side shown to the right in Figure 20 of a device of release of the accessory out of the clamp;
  • FIG. 22 is a schematic view showing how cooperates according to the invention a straw, a filling accessory, a suction nozzle, a pipette tip and a receptacle disposed in a receptacle holder in a position where the pipette tip cooperates with the receptacle containing a liquid substance;
  • Figure 23 is a view similar to Figure 22 but in a position where the pipette tip is disposed above the inlet opening of the accessory, after taking from the receptacle a certain amount of liquid substance;
  • - Figure 24 is a view similar to Figure 22 but in a position where the content of the pipette tip has been transferred to the accessory;
  • Figure 25 is a view similar to Figure 22 but in a position where the accessory and the suction nozzle are engaged tightly in the tube of the flake;
  • - Figure 26 is a view similar to Figure 22 but in a position where a predetermined dose of liquid substance is introduced into the tube of the straw; and
  • the accessory 1 illustrated in Figures 1 to 5 comprises a spout 2 and a body 3.
  • the spout 2 is integral with the body 3 and protrudes transversely to the body.
  • the spout 2 is formed of a single molded piece of rigid plastic material and comprises a capillary channel 4 extending here over the entire length of the spout 2 between a first end having a passage 5, through which the channel 4 communicates with the space defined by the body 3, and a second end having an outlet port 6.
  • a first portion 7 'of the spout 2 having a frustoconical outer surface 7 "extends from the body 3 to mid-length of the spout 2 in a decreasing section and is extended by a second portion 8' of the spout having a cylindrical outer surface 8 "extending from the first portion T to the distal end of the spout 2.
  • the cylindrical portion 8 has a draft of approximately 0.5 °.
  • the body 3 comprises a tubular wall subdivided into two portions 9 and 10 by a bottom wall 11.
  • the portion 9 delimits with the wall 11 a reservoir for containing a liquid substance.
  • This reservoir has an inlet opening 12 at the end opposite to the bottom wall 11.
  • the portion 10 forms a base on which the support is supported.
  • the bottom wall 11 is here inclined at an angle of 30 ° with respect to the spout 2.
  • the capillary channel 4 communicates with the body 3 through the passage 5, the lower part of which opens out flush with the lower part of the wall. bottom 11 of the body 3, ie at the lowest level of the tank.
  • the body 3 is generally oriented in a direction transverse to the general orientation of the spout 2, the accessory 1 thus having a generally bent shape.
  • the body 3 Opposite the spout 2, the body 3 comprises, on its outer face, a rigid rib 13, a single block with the body 3 and generally parallelepipedal shape.
  • Two tabs 14 of a single block with the body 3 and diametrically opposite one another, are arranged on the outer face of the body 3, at the same level and midway between the rib 13 and the beak 2.
  • Two lugs 15 are located on either side of each tongue 14. In line with each tongue 14, a notch 16 is formed at the end of the body 3 bordering the opening 12.
  • the variant 1 'of the accessory illustrated in FIG. 6 will now be described.
  • the same references are used for the identical elements as for the accessory 1.
  • the accessory is identical to the accessory 1 if it is that the bottom wall 11 'of the body 3 has a lower inclination, here of 4.5 ° with respect to the spout 2.
  • the clamp 30 for grasping the accessory 1 comprises a central body 31 and two elastically deformable arms 34.
  • the central body 31 has a generally parallelepipedal shape having two square faces 32, and extending from one to the other on each side of the square faces, four similar rectangular faces 33.
  • One of the rectangular faces 33 has in its center a connection port 35 to a robotic arm.
  • the two arms 34 are connected transversely to the rectangular face 33 opposite that having the orifice 35.
  • Each arm 34 has a section 36 of parallelepipedal shape and a hook 37, in the extension of the section 36 and opposite the hook 37 of the other arm.
  • Each hook 37 has a convex surface 38 and a recessed straight surface 39 with respect to the section 36, a straight surface 40 connecting the convex surface 38 to the recessed surface 39 and a surface 41 connecting the recessed surface 39 to the section 36.
  • the junction of the convex surface 38 and the straight surface 40 points towards the other hook 37 while the junction between the straight surface 40 and the recessed surface 39 points towards the hook 37 to which it belongs.
  • junction of the recessed surface 39 with the surface 41 points towards the hook 37 to which it belongs while the junction of this surface 41 with the section 36 forms a shoulder 42.
  • the accessory holder 60 on which the accessory comes to bear during the filling step will now be described with reference to FIGS. 13 to 17.
  • the accessory holder 60 comprises a pedestal 61 of generally parallelepipedal shape and two tabs 62 projecting from the base 61.
  • the base 61 has two rectangular main faces 63, two rectangular faces 64 extending from one to the other of the long sides of the main faces 63 and two rectangular faces 65 extending from one to the other of the small sides of the main faces 63.
  • One of the faces 64 rests on a plate 70 belonging to a movable carriage which is not represented further.
  • the tabs 62 are connected to the base 61 by the other face 64, beyond it, in the extension of an angle between a face 63 and a face 65.
  • the tabs 62 are separated from each other for a groove 66 of frustoconical profile whose section is increasing from the face 65 closest to the face 65 farthest from the groove 66.
  • Each tab 62 has a section of generally triangular shape and has on its face adjacent to the groove 66 where the section is the widest, a recess in a circular arc 67 whose radius of curvature is identical to the radius of curvature of the body 3 and a flange 68 protruding in the extension of the recess 67 on the opposite side to the groove 66.
  • the pusher 50 comprises a presser 53 and a jack formed of a rod 51 and a body 52.
  • the rod 51 is connected at one end to the presser 53 and at the other end to a piston (not visible in the drawings) movable inside the body 52.
  • Presser 53 is here of parallelepipedal general shape.
  • the rectangular face opposite the face by which it is connected to the rod 51 has a recess in an arc of circle whose radius of curvature is identical to the radius of curvature of the body 3.
  • the clamp holder 80 illustrated in FIGS. 18 and 19 comprises a base 88 of generally parallelepipedal shape having two main faces 81 and, extending from one to the other of the long sides of the main faces, two similar rectangular faces 82 , and from one to the other of the short sides of the main faces two similar rectangular faces 83.
  • the base 88 has a cavity 87 opening on one of the faces 83 through an opening 84.
  • a lug 85 controlled by a motor 86 is housed in the cavity 87.
  • the release device of the accessory illustrated in FIGS. 20 and 21 comprises a rod 90 connected transversely to a fixed vertical wall 91.
  • the robotic arm 95 illustrated in FIGS. 18 to 21, has a pipette rod 96, the distal end of which can, as will be seen below, be engaged in the orifice 35 of the clamp 30 as pipet tip 24.
  • the arm 95 includes pneumatic means for performing a vacuum in a pipette tip to aspirate a liquid substance and to suppress the vacuum in the pipette tip to release the liquid contained in the pipette tip.
  • the containers open on the top containing the liquid substances to be packaged here are primary tubes 45 of glass (of the test tube type) previously arranged in a receptacle holder 46 (FIGS. 22 and 23) such a carousel or rack with primary tubes.
  • This receptacle holder separate from the accessory holder 60 preinstalled in the machine, is manually loaded into the machine before starting a cycle.
  • tip holder here a pipette tip rack not shown
  • accessory box here an accessory rack not shown
  • Empty flakes 25 are also disposed manually in a glitter distribution hopper not shown in the figures.
  • the robotic arm 95 manipulable in the three dimensions of the space, is placed above the clamp holder 80.
  • the robotic arm 95 is lowered towards the clamp holder 80, the male end of the pipette rod 96 of the arm 95 engages in the hole 35 of the clamp 30, as shown in FIGS. 18 and 19.
  • the motor 86 is then controlled to retract the lug 85.
  • the robotic arm 95 provided with the clamp 30 is then moved over the accessory rack (not shown).
  • the seized accessory is moved from the accessory rack (not shown) to the top of the accessory holder 60 and is engaged from above in the accessory holder 60 to be deposited as illustrated in FIG. 13 on the support surface. 64 of the base 61 of the accessory-holder 60.
  • the spout 2 is oriented by the robotic arm 95 so as to engage in the frustoconical groove 66.
  • the presser 53 is then moved to come into contact with the accessory so that the arcuate recess 54 of the presser 53 bears against the portion 9 of the accessory 1 on the side opposite the spout 2, whereby the accessory slides horizontally on the accessory-holder 60 of its removal position, illustrated in FIGS. 13 and 15, at an abutment position against the lugs 62 of the accessory-holder 60, illustrated in FIGS. 16 and 17.
  • the rib 13 of the accessory 1 is located under the lower surface 55 of the presser 53.
  • the frustoconical portion T of the spout 2 of the accessory holder 60 is guided by the frustoconical groove 66, whereby the outlet orifice 6 is precisely positioned opposite and in the center of the end 21 of the thin tube 20 of a straw 25 as illustrated in FIG.
  • the straw 25 has been brought by a conveyor belt not shown in the illustrated position, where it must be filled.
  • the embossment 10 makes it possible to orient the capillary channel 4 along the axis of the straw 25 independently of the inclination of the bottom wall 11, whereby in the abutment position on the accessory-holder 60, the capillary channel 4 is parallel and centered with respect to the flake 25.
  • the body 3 is then in the upright position, while the spout 2, oriented transversely to the body 3 is like the straw 25 in the supine position.
  • the robotic arm 95 can therefore be reassembled so as to elastically disengage the tongues 14 of the accessory 1 of the hooks 37 of the clamp
  • the inclination of the straight surface 40 of the hook 37 relative to the tongue 14 facilitates the stall.
  • the robotic arm 95 then rests the clamp 30 in the clamp holder 80.
  • the motor 86 is then controlled so that the lug 85 presses on one of the sections 36 of the clamp 30 in order to hold it in position when the arm is reassembled to
  • the arm 95 is then placed at the top of the pipette tip rack (not shown) in order to plug the male end of the pipette rod 96 of the robotic arm 95 into a pipette tip 24 (FIG. Figures 22 and 23).
  • the robotic arm 95 provided with the pipette tip 24 in the upright position is then placed above one of the open-top receptacles 45 containing the liquid substance to be conditioned in order to co-operate the pipette tip 24 with the receptacle 45. its opening 47: the distal end of the pipette tip 24, in the upright position, is immersed in the liquid substance as illustrated in FIG.
  • Depression is then generated in the pipette tip 24 so that it can aspirate an amount of liquid substance (Figure 23) containing at least a predetermined dose 26 'of liquid substance (Figure 26).
  • the arm 95 provided with the pipette tip 24 filled with the quantity of liquid 26 that it contains is then, as shown in FIG. 23, disposed above the body 3 of the accessory 1, always in abutment position on the accessory holder 60.
  • the depression is then removed in the pipette tip 24, still in the upright position, so that the quantity of liquid 26 is released from the pipette tip 24 and is collected in the body 3 of the accessory 1 as shown in FIG. 24.
  • the distal end of the pipette tip 24 is here placed above the opening 12 but it is also possible to place it below, at the top of the reservoir of the accessory 1.
  • FIGS. 27 and 28 other modes of cooperation between a pipette tip 24 and a filling accessory are possible for passing the liquid substance from the pipette tip 24 into a dispensing accessory. filling.
  • the capillary channel 4 of the spout 2 and the body 3 are dimensioned so that when the body 3 of the accessory is filled, as illustrated in FIG. 24, and maintained at atmospheric pressure, the channel 4 is 'opposes by capillarity to the circulation of the liquid substance in the absence of depression, given the viscosity of this substance.
  • the liquid does not flow through the capillary duct 4 as the outlet port 6 is not subjected to a depression.
  • the straw 25 illustrated in FIGS. 22 to 26 is disposed on an unillustrated conveyor belt, and more precisely in a group of calibrated notches where it has been automatically engaged from a hopper, the carpet having a regular succession of groups. of notches, the straws placed on the carpet being perpendicular to the direction of advance thereof.
  • the trolleys (not shown) on which the suction nozzle 27 and the accessory 1 are mounted respectively are movable in translation transversely to the conveyor belt, that is to say in the direction of the straw 25. They perform movements back and forth between a retracted position and a work position.
  • the accessory 1 is deposited in the accessory holder 60 while the carriage which carries it is in the retracted position. When moving the carriages from their retracted position to their working position, the carriages advance towards the straw 25 and the spout 2 and the nozzle 27 each enter the tube 20.
  • the flexible nature of the plastic forming the tube 20 ensures a good seal with the spout 2 even if it is made of rigid plastic material.
  • the joint plane of the mold of the accessory 1 is here disposed away from the wall 7 "so as not to disturb the sealed cooperation of the flake 25 with the frustoconical surface 7".
  • the vacuum source 29 then generates a depression in the straw 25 which results in the flow of a predetermined dose 26 'of liquid substance from the reservoir of the accessory 1 to the tube 20 via the capillary channel 4.
  • the inclined bottom wall 11 facilitates the flow of the fluid and avoids or in any case limits the turbulence phenomena caused by sudden changes in direction.
  • the composite plug 23 of the straw 25 remains permeable to air as long as the powder 23 ', included between the two porous pads 23 ", has not gelled by contact with an aqueous liquid, in this case the liquid biological substance. to condition.
  • the composite plug 23 is therefore impervious.
  • the carriages are then driven to the retracted position and the filled straw is thus released from the spout 2 and the nozzle 27.
  • the residual liquid substance 26 "contained in the reservoir after filling the straw does not flow through the capillary channel. 4 for the same reasons as previously stated.
  • the carpet is then advanced to place a new straw 25 to fill in the filling position and to place the filled straw in the welding position of its ends.
  • each accessory 1 may fill one or more sequins 25.
  • the accessory may also be filled one or several times by the robotic arm 95.
  • the replacement of the pipette tip 24 is well known and is conventionally effected by ejecting the used tip 24 out of the pipette rod 96 over a container for storing used consumables and by fitting the connection element. male of the pipette rod 96 of the robotic arm 95 into a new pipette tip 24 disposed in the tip holder.
  • the accessory 1 is grasped by the robotic arm 95 provided with the clamp 30 after the presser has moved back to the position it occupied when the accessory was in the removal position.
  • the clamp 30 provided with the accessory 1 is directed towards the release device in order to place the rod 90 between the central body 31 of the clamp 30 and the accessory 1, on either side of the sections 36 (FIGS. 21).
  • the rod 90 bears against the body 3 of the accessory 1 which is thus disengaged from the clamp 30 and falls into the used consumables storage container.
  • the clamp 30 is then available to enter a new accessory 1 in the accessory rack.
  • the accessory 101 comprises a body 103 having a frustoconical wall and comprises a spout 102 projecting transversely to the body 103.
  • the body 103 extends between an inlet opening 112 and a bottom wall 111.
  • the spout 102 has a cylindrical portion 108 ', one end of which is connected by interlocking in the body 103, and a pellet 107' attached to the cylindrical portion 108 'and having a frustoconical surface 107 ".
  • the accessory 201 is similar to the accessory 101 with the difference that the nozzle 202 of the accessory 201 is formed in one piece with the body 203 also having a wall truncated.
  • the accessories 101 and 201 are used as the accessory 1 with the difference that they cooperate in mechanical connection with the pipette tip 24 since it is received interlocking in the frustoconical portion of the body 103 or 203 through the entrance opening 112 or 212.
  • the filling accessory 101 or 201 is provided, as the accessory 1, various elements for cooperation with a clamp such as the clamp 30, in this case a rib such as 13, tongues and tabs such as 14 and 15 and notches such as 16.
  • the filling accessory 101 or 201 is provided, as the accessory 1, a nozzle such as 2 having a cylindrical portion and a frustoconical portion such as 8 'and T.
  • the filling accessory 1 is provided, as the accessory 101 of a spout such as 102 having a cylindrical portion such as 108 'on which is reported a frustoconical pellet such as 107'.
  • the bottom wall 11 of the accessory 1 can be inclined at an angle of between 25 ° and 35 ° relative to the spout 2.
  • the bottom wall 11 'of the accessory 1' can be inclined at an angle of between 2.5 ° and 6.5 ° with respect to the spout 2.
  • the channel that includes the nozzle of the accessory is not capillary over the entire length of the nozzle but only on a portion located in the vicinity of the outlet to prevent spontaneous flow liquid through the spout.

Abstract

The inventive device is provided with a unit (1) comprising a body (3) which interacts with a pipette tip (24) in a vertical position in order to retain the content of the pipette tip (24) in the unit (1) and comprises a nozzle (2) having a capillary channel (4) insertable into a straw (25) oriented in a transversal position with respect to the body in such a way that, when the body is in a vertical position, said nozzle (2) is in a horizontal position. The inventive method consists in sampling a liquid substance initially contained in a top-open container (45) with the aid of the pipette tip (24) in the vertical position, in transferring the content of pipette tip (24) to the body (3) of the unit (1) prior to filling the straw (25) with the predetermined dose of a liquid substance transferred thereto from the unit (1).

Description

Procédé pour conditionner dans une paillette une dose prédéterminée de substance liquide et dispositif pour le mettre en œuvreMethod for conditioning in a straw a predetermined dose of liquid substance and device for carrying it out
La présente invention concerne le conditionnement de doses prédéterminées de substance liquide dans des paillettes.The present invention relates to the conditioning of predetermined doses of liquid substance in flakes.
On sait que les paillettes sont des unités de conditionnement formées d'un tube mince en matière plastique dont le diamètre intérieur est en particulier suffisamment faible pour permettre le maintien en place de la dose de substance liquide par capillarité et d'un bouchon engagé dans le tube mince à proximité d'une extrémité, comportant deux tampons poreux et, entre ces deux tampons, un volume de poudre gélifiante, c'est-à-dire se transformant en gel au contact d'un liquide aqueux.It is known that flakes are conditioning units formed of a thin plastic tube whose inner diameter is in particular sufficiently small to allow the retention in place of the dose of liquid substance by capillarity and a plug engaged in the thin tube near one end, having two porous pads and, between these two buffers, a volume of gelling powder, that is to say, turning into gel in contact with an aqueous liquid.
On connaît déjà, notamment par la demande de brevet européen 0 480 109, un procédé de conditionnement comportant une étape de remplissage pour faire pénétrer une dose prédéterminée de substance liquide, initialement contenue dans un réceptacle ouvert sur le dessus, dans le tube mince d'une paillette. Cette étape s'opère en emboîtant de manière étanche un accessoire de remplissage dans une première extrémité du tube mince de la paillette tandis que la seconde extrémité de ce tube mince est reliée à une source de vide, avec la paillette qui est en position couchée, et avec un conduit de l'accessoire de remplissage qui est plongé dans la substance liquide contenue dans le réceptacle. La dépression engendrée dans la paillette par la source de vide entraîne l'écoulement de la substance liquide du réceptacle vers la paillette, via l'accessoire de remplissage. La demande de brevet européen 0 856 298 décrit une version perfectionnée de l'accessoire de remplissage.A packaging method comprising a filling step for penetrating a predetermined dose of liquid substance, initially contained in an open receptacle on the top, into the thin tube of the invention is already known, in particular from the European Patent Application 0 480 109. a straw. This step is effected by sealingly fitting a filling accessory in a first end of the thin tube of the straw while the second end of this thin tube is connected to a vacuum source, with the straw which is in a supine position, and with a conduit of the filling accessory which is immersed in the liquid substance contained in the receptacle. The depression generated in the straw by the vacuum source causes the flow of liquid substance from the receptacle to the straw, via the filling accessory. European Patent Application 0 856 298 discloses an improved version of the filling accessory.
Il existe, pour mettre en œuvre ce procédé, une machine sur laquelle l'accessoire et le réceptacle sont montés manuellement respectivement sur un porte-accessoire et sur un porte-réceptacle d'un chariot mobile réalisant des mouvements de va-et-vient coordonnés avec le déplacement transversal d'un tapis transportant les paillettes à remplir de façon à engager puis désengager l'accessoire de remplissage dans puis hors d'une paillette du tapis, puis dans la paillette suivante et ainsi de suite avec les paillettes successives. Lorsque la substance liquide à conditionner doit être changée ou lorsque le réceptacle disposé dans le porte-accessoire est vide, l'on doit : retirer l'accessoire de remplissage du porte-accessoire ; retirer le réceptacle du porte-réceptacle ; - placer un autre réceptacle dans le porte-réceptacle ; monter un nouvel accessoire de remplissage sur le porte- accessoire ; et plonger le conduit de ce nouvel accessoire dans la substance liquide contenue dans le réceptacle. L'invention vise à automatiser davantage le remplissage des paillettes d'une manière simple, commode et économique.There is, to implement this method, a machine on which the accessory and the receptacle are mounted manually respectively on an accessory holder and on a receptacle-holder of a moving carriage performing coordinated back and forth movements. with the transverse displacement of a carpet carrying the flakes to fill so as to engage and then disengage the filling accessory in and out of a flake of the carpet, then in the next straw and so on with the sequins sequants. When the liquid substance to be conditioned has to be changed or when the receptacle in the accessory holder is empty, the following must be done: remove the accessory from the accessory holder; remove the receptacle from the receptacle holder; placing another receptacle in the receptacle holder; mount a new filling accessory on the accessory holder; and plunge the conduit of this new accessory into the liquid substance contained in the receptacle. The invention aims to further automate the filling of straws in a simple, convenient and economical way.
Elle propose à cet effet un procédé pour conditionner dans une paillette une dose prédéterminée de substance liquide initialement contenue dans un réceptacle ouvert sur le dessus, comportant une étape de remplissage pour faire pénétrer ladite dose prédéterminée dans ladite paillette, disposée en position couchée, avec un accessoire de remplissage emboîté dans ladite paillette, lequel procédé est caractérisé en ce qu'il comporte, préalablement à l'étape de remplissage : l'étape de faire coopérer une pointe de pipette, en position debout, avec ledit réceptacle pour y prélever au moins une dite dose de substance liquide ; l'étape de se procurer un dit accessoire présentant un corps adapté à coopérer avec ladite pointe de pipette, en position debout, et présentant un bec à canal capillaire adapté à être emboîté dans ladite paillette, lequel bec est orienté transversalement audit corps de sorte que quand ledit corps est en position debout ledit bec est en position couchée ; et l'étape de faire coopérer ladite pointe de pipette, en position debout, contenant au moins ladite dose, avec ledit corps pour que le contenu de ladite pointe de pipette appartienne à cet accessoire. II suffit alors d'emboîter le bec dans la paillette et de mettre en œuvre l'étape de remplissage de façon classique.It proposes for this purpose a method for conditioning in a straw a predetermined dose of liquid substance initially contained in a receptacle open on the top, comprising a filling step for causing said predetermined dose to penetrate into said straw, arranged in a lying position, with a filling device fitted into said straw, which method comprises, prior to the filling step: the step of cooperating a pipette tip, in a standing position, with said receptacle to collect at least a said dose of liquid substance; the step of obtaining an said accessory having a body adapted to cooperate with said pipette tip, in a standing position, and having a capillary channel nozzle adapted to be fitted into said straw, which nozzle is oriented transversely to said body so that when said body is in a standing position said beak is in a supine position; and the step of cooperating said pipette tip, in a standing position, containing at least said dose, with said body so that the contents of said pipette tip belong to this accessory. It suffices then to fit the beak in the straw and to implement the filling step in a conventional manner.
Le caractère capillaire du canal ménagé dans le bec permet au contenu de l'accessoire, provenant de la pointe de pipette, de demeurer dans l'accessoire tant que la source de vide n'a pas engendré dans la paillette la dépression produisant l'écoulement de la substance liquide.The capillary nature of the channel in the spout allows the content of the accessory, from the pipette tip, to remain in the the accessory as long as the source of vacuum has not generated in the straw the depression producing the flow of the liquid substance.
On voit que grâce à l'accessoire qu'utilise le procédé selon l'invention, il est possible de se servir d'un automate conventionnel à pointes de pipette pour effectuer le prélèvement de liquide dans le réceptacle ouvert sur le dessus.It can be seen that, thanks to the accessory used in the method according to the invention, it is possible to use a conventional pipette-tip automaton to carry out the sampling of liquid in the receptacle open on the top.
Le remplacement de l'opération manuelle de plongée du conduit de l'accessoire dans le réceptacle contenant initialement la substance liquide à conditionner, par une opération automatique mettant en œuvre une pointe de pipette, offre l'avantage d'une plus grande sécurité, notamment sur le plan sanitaire.The replacement of the manual dive operation of the conduit of the accessory in the receptacle initially containing the liquid substance to be conditioned, by an automatic operation using a pipette tip, offers the advantage of greater safety, in particular on the sanitary level.
Comme on le verra ci-après, il est avantageusement possible, notamment grâce aux caractéristiques préférées exposées ci-après, de se servir de l'automate à pointes de pipette pour manipuler non seulement les pointes de pipettes, mais aussi les accessoires de remplissage. Selon des caractéristiques préférées, pour des raisons de simplicité et de commodité tant à la fabrication qu'à l'utilisation :As will be seen below, it is advantageously possible, particularly thanks to the preferred features set out below, to use the pipette tip automaton to handle not only the pipette tips, but also the filling accessories. According to preferred features, for reasons of simplicity and convenience both in manufacture and use:
• le procédé comporte en outre, préalablement à l'étape de remplissage :The method further comprises, prior to the filling step:
- l'étape de mettre en place l'accessoire dans un porte- accessoire appartenant à un chariot mobile alors que celui-ci est dans une position rétractée ; etthe step of placing the accessory in an accessory holder belonging to a mobile carriage while the latter is in a retracted position; and
- l'étape de déplacer le chariot de ladite position rétractée à une position de travail pour emboîter de façon étanche ledit accessoire dans ladite paillette. • le procédé comporte préalablement à l'étape de faire coopérer ladite pointe de pipette avec ledit réceptacle :- The step of moving the carriage from said retracted position to a working position for sealingly fitting said accessory in said straw. The method comprises prior to the step of cooperating said pipette tip with said receptacle:
- l'étape d'emboîter ladite pointe de pipette dans une pipette ; tandis que l'étape de faire coopérer ladite pointe de pipette avec ledit réceptacle comporte : - l'étape de disposer ladite pipette munie de ladite pointe de pipette au dessus dudit réceptacle ;the step of fitting said pipette tip into a pipette; while the step of cooperating said pipette tip with said receptacle comprises: - the step of disposing said pipette provided with said pipette tip above said receptacle;
- l'étape de plonger l'extrémité de ladite pointe de pipette dans ladite substance liquide contenue dans ledit réceptacle ; et - l'étape de créer une dépression dans ladite pointe de pipette pour aspirer ladite substance liquide ;the step of immersing the end of said pipette tip in said liquid substance contained in said receptacle; and the step of creating a depression in said pipette tip for sucking said liquid substance;
• l'étape de faire coopérer ladite pointe de pipette contenant au moins ladite dose avec ledit accessoire comporte : - l'étape de disposer ladite pointe de pipette contenant au moins ladite dose au dessus dudit accessoire ; etThe step of cooperating said pipette tip containing at least said dose with said accessory comprises: the step of disposing said pipette tip containing at least said dose over said accessory; and
- l'étape de supprimer la dépression dans ladite pointe de pipette pour libérer le contenu de ladite pointe de pipette.the step of removing the depression in said pipette tip to release the contents of said pipette tip.
• dans le procédé : - l'étape de faire coopérer ladite pointe de pipette, en position debout, avec ledit réceptacle pour y prélever ladite dite dose de substance liquide ; etIn the method: - the step of cooperating said pipette tip, in a standing position, with said receptacle to take said said dose of liquid substance; and
- l'étape de faire coopérer ladite pointe de pipette, en position debout, contenant au moins ladite dose, avec ledit accessoire pour que le contenu de ladite pointe de pipette appartienne à cet accessoire sont réalisées automatiquement.- The step of cooperating said pipette tip, upright, containing at least said dose, with said accessory so that the content of said pipette tip belongs to this accessory are performed automatically.
• le procédé comporte, préalablement auxdites étapes réalisées automatiquement :The method comprises, prior to said steps automatically carried out:
- l'étape de mettre en place manuellement une boîte à accessoires comportant ledit accessoire ;the step of manually setting up an accessory box comprising said accessory;
- l'étape de mettre en place manuellement un porte-réceptacle comportant ledit réceptacle ; etthe step of manually setting up a receptacle holder comprising said receptacle; and
- l'étape de mettre en place manuellement un porte-pointe comportant ladite pointe de pipette. • on sélectionne comme boîte à accessoires un râtelier à accessoires ;the step of manually setting up a tip-holder comprising said pipette tip. A accessory rack is selected as an accessory box;
• on sélectionne comme porte-pointe un râtelier à pointes de pipette ;A tip rack is selected as a spike holder;
• on sélectionne comme porte-réceptacle un râtelier à réceptacles ; • on sélectionne comme porte-réceptacle un carrousel à réceptacles ; et/ouA receptacle rack is selected as a receptacle holder; A receptacle carousel is selected as a receptacle holder; and or
• le procédé comporte, préalablement à l'étape de remplissage : - l'étape de déplacer ledit accessoire de ladite boîte à accessoires jusqu'au dessus d'un porte-accessoire ;The process comprises, prior to the filling step: the step of moving said accessory from said accessory box to the top of an accessory holder;
- l'étape d'engager par le dessus ledit accessoire dans ledit porte-accessoire pour le déposer ; et - l'étape de faire glisser horizontalement ledit accessoire par rapport audit porte-accessoire d'une position de dépose sur ledit porte- accessoire jusqu'à une position de butée contre ledit porte-accessoire.- The step of engaging from above said accessory in said accessory holder for the deposit; and the step of horizontally sliding said accessory relative to said accessory-holder from a removal position on said accessory-holder to an abutment position against said accessory-holder.
On notera que ces caractéristiques sont susceptibles d'être mises en œuvre indépendamment des caractéristiques exposées précédemment. De préférence :Note that these characteristics are likely to be implemented independently of the features described above. Preferably:
• l'étape de déplacer ledit accessoire comporte :The step of moving said accessory comprises:
- l'étape de se procurer une pince ;the step of obtaining a clamp;
- l'étape de saisir par ladite pince ledit accessoire dans ladite boîte à accessoires ; et - l'étape de disposer ladite pince munie dudit accessoire au dessus dudit porte-accessoire ; et/ou- The step of gripping said gripper said accessory in said accessory box; and - the step of arranging said clamp provided with said accessory above said accessory holder; and or
• l'étape de faire glisser ledit accessoire comporte l'étape de déplacer un poussoir plaqué contre ledit accessoire.• The step of sliding said accessory comprises the step of moving a plunger pressed against said accessory.
L'invention vise également, sous un deuxième aspect, un dispositif convenant à la mise en œuvre du procédé exposé ci-dessus, ce dispositif comportant un accessoire adapté à être emboîtée dans une paillette en position couchée pour y introduire une dose prédéterminée de substance liquide initialement contenue dans un réceptacle ouvert sur le dessus, caractérisé en ce que ledit accessoire présente un corps adapté à coopérer avec une pointe de pipette en position debout pour que le contenu de ladite pointe de pipette appartienne à cet accessoire, et présente un bec à canal capillaire adapté à être emboîté dans ladite paillette, orienté transversalement audit corps de sorte que quand ledit corps est en position debout ledit bec est en position couchée.The invention also aims, in a second aspect, a device suitable for implementing the method set out above, this device comprising an accessory adapted to be fitted into a straw in the prone position to introduce a predetermined dose of liquid substance initially contained in a receptacle open on the top, characterized in that said accessory has a body adapted to cooperate with a standing pipette tip so that the contents of said pipette tip belong to this accessory, and has a channel nozzle capillary adapted to be fitted into said straw, oriented transversely to said body so that when said body is in a standing position said nozzle is in the supine position.
Selon des caractéristiques préférées, pour des raisons de simplicité et de commodité tant à la fabrication qu'à l'utilisation :According to preferred features, for reasons of simplicity and convenience both in manufacture and use:
• ledit corps comporte une paroi de fond ;Said body comprises a bottom wall;
• ladite paroi de fond est inclinée d'un angle compris entre 25° et 35° par rapport audit bec ; • ladite paroi de fond est inclinée d'un angle compris entre 2,5° et 6,5° par rapport audit bec ;Said bottom wall is inclined at an angle of between 25 ° and 35 ° with respect to said spout; Said bottom wall is inclined at an angle of between 2.5 ° and 6.5 ° with respect to said spout;
• ledit bec comporte ledit canal capillaire sur toute sa longueur ;Said nozzle comprises said capillary channel over its entire length;
• ledit corps comporte une paroi de fond et ledit canal capillaire s'étend d'un orifice de sortie jusqu'à un passage qui communique avec un espace délimité par ledit corps et ladite paroi de fond ;Said body comprises a bottom wall and said capillary channel extends from an outlet orifice to a passage which communicates with a space delimited by said body and said bottom wall;
• la partie basse dudit passage est à fleur de la partie la plus basse de ladite paroi de fond dudit corps ;• the lower part of said passage is flush with the lowest part of said bottom wall of said body;
• ledit bec comporte une portion cylindrique et une portion tronconique ;Said nozzle comprises a cylindrical portion and a frustoconical portion;
• ledit bec comporte une portion cylindrique et une pastille tronconique rapportée sur ladite portion cylindrique ;Said nozzle comprises a cylindrical portion and a frustoconical pellet attached to said cylindrical portion;
• ledit corps comporte une paroi de fond et une paroi tubulaire subdivisée en une première portion tubulaire et une seconde portion tubulaire par ladite paroi de fond ;Said body comprises a bottom wall and a tubular wall subdivided into a first tubular portion and a second tubular portion by said bottom wall;
• ladite première portion et ladite paroi de fond délimitent un réservoir pour contenir ladite substance liquide tandis que ladite seconde portion tubulaire forme un embasement sur lequel prend appui ledit accessoire ;Said first portion and said bottom wall define a reservoir for containing said liquid substance while said second tubular portion forms a base on which abuts said accessory;
• ledit corps comporte une paroi de fond et une paroi tronconique s'étendant d'une ouverture d'entrée jusqu'à ladite paroi de fond ;Said body comprises a bottom wall and a frustoconical wall extending from an inlet opening to said bottom wall;
• ledit accessoire présente une nervure à l'opposé dudit bec ;Said accessory has a rib opposite said nose;
• ledit accessoire présente deux languettes à l'opposé l'une de l'autre sur ledit corps ;Said accessory has two tabs opposite one another on said body;
• ledit accessoire comporte deux pattes de part et d'autre de chacune desdites languettes ;Said accessory comprises two tabs on either side of each of said tabs;
• ledit accessoire comporte deux encoches bordant une ouverture d'entrée au dessus desdites languettes ;Said accessory comprises two notches bordering an inlet opening above said tongues;
• ledit dispositif comporte, en outre de l'accessoire, une pince présentant un corps central et deux bras élastiquement déformables reliés audit corps central comportant dans leur partie distale un crochet apte à s'engager ou se désengager de ladite languette respective dudit accessoire par déformation élastique desdits bras ; • lesdits bras, comportent un tronçon disposé entre ledit corps central et ledit crochet ;Said device comprises, in addition to the accessory, a clamp having a central body and two elastically deformable arms connected to said central body having in their distal portion a hook adapted to engage or disengage said respective tongue of said accessory by deformation elastic of said arms; Said arms comprise a section disposed between said central body and said hook;
• ledit crochet présente une surface convexe contre laquelle vient en appui ladite languette pour contraindre élastiquement lesdits bras ; • ledit accessoire comporte deux encoches bordant une ouverture d'entrée et chaque bras présente, à la jonction entre ledit tronçon et ledit crochet, un épaulement apte à se loger dans ladite encoche respective dudit accessoire lorsque lesdits crochets sont engagés dans lesdites languettes ;Said hook has a convex surface against which said tongue presses to elastically constrain said arms; • said accessory comprises two notches bordering an inlet opening and each arm has, at the junction between said section and said hook, a shoulder adapted to be housed in said respective notch of said accessory when said hooks are engaged in said tabs;
• ledit dispositif comporte, en outre de l'accessoire, un porte- accessoire comportant un socle sur lequel prend appui ledit accessoire lorsqu'il repose sur ledit porte-accessoire et des pattes contre lesquelles ledit accessoire vient en butée lorsque ledit accessoire est dans une position de butée, ledit bec saillant au delà desdites pattes ;Said device comprises, in addition to the accessory, an accessory holder comprising a base on which said accessory rests when it rests on said accessory-holder and lugs against which said accessory abuts when said accessory is in a abutment position, said protruding beak beyond said tabs;
• lesdites pattes présentent un renfoncement en arc de cercle contre lequel vient en butée ledit accessoire dans ladite position de butée ;• said tabs have a recess arcuate against which abuts said accessory in said stop position;
• lesdites pattes sont séparées par une rainure à profil tronconique dans lequel se loge ledit accessoire ;Said tabs are separated by a frustoconical groove in which said accessory fits;
• ledit accessoire présente deux languettes à l'opposé l'une de l'autre sur ledit corps et deux pattes de part et d'autre de chacune desdites languettes et lesdites pattes dudit porte-accessoire présentent du coté opposé à ladite rainure tronconique un rebord saillant sous lequel se loge une dite patte dudit accessoire lorsque ledit accessoire est dans ladite position de butée ;Said accessory has two tabs opposite each other on said body and two tabs on either side of each of said tabs and said tabs of said accessory holder have on the opposite side to said frustoconical groove a rim; protruding under which is housed a said tab of said accessory when said accessory is in said abutment position;
• ledit dispositif comporte, en outre de l'accessoire, un poussoir comportant un presseur et un vérin comportant une tige et un corps, ledit presseur étant apte à venir en appui contre ledit accessoire pour que l'accessoire glisse d'une première position à une seconde position ;Said device comprises, in addition to the accessory, a pusher comprising a presser and a jack comprising a rod and a body, said presser being able to bear against said accessory so that the accessory slides from a first position to a second position;
• ledit presseur présente un renfoncement en arc de cercle pour venir au contact dudit accessoire ;Said presser has a recess in an arc to come into contact with said accessory;
• ledit accessoire présente une nervure à l'opposé dudit bec et ledit presseur et ladite nervure présentent un agencement apte à ce que ladite nervure se loge sous la surface inférieure dudit presseur lorsque ledit presseur vient au contact dudit accessoire ; et/ou • ledit accessoire présente un bec à canal capillaire formé d'un seul bloc rigide adapté à être emboîté dans ladite paillette.Said accessory has a rib opposite said spout and said presser and said rib have an arrangement adapted for said rib to be housed under the lower surface of said presser when said presser comes into contact with said accessory; and or Said accessory has a capillary channel nozzle formed of a single rigid block adapted to be fitted into said straw.
On observera que ces caractéristiques sont susceptibles d'être mises en œuvre indépendamment des caractéristiques exposées précédemment. De préférence :It will be observed that these characteristics are capable of being implemented independently of the characteristics described above. Preferably:
• ledit bec comporte une portion tronconique et une portion cylindrique ;Said nozzle comprises a frustoconical portion and a cylindrical portion;
• ledit bec comporte un canal capillaire ; et/ouSaid beak comprises a capillary channel; and or
• ledit bec est moulé d'une seule pièce en matière plastique rigide. Les caractéristiques et avantages de l'invention ressortiront de la description qui suit, donnée à titre d'exemple préféré, mais non limitatif, en référence aux dessins annexés, sur lesquels : les figures 1 et 2 sont deux vues en perspective prises sous deux angles différents présentant isolément un accessoire de remplissage conforme à l'invention ; les figures 3, 4 et 5 montrent cet accessoire respectivement suivant une vue en élévation prise du coté qu'on voit à gauche sur la figure 1 , une vue en plan de dessus et une vue en élévation-coupe comme montré en V- V sur la figure 3 ; - la figure 6 est une vue similaire à la figure 5 illustrant une variante de cet accessoire dans laquelle la paroi de fond est faiblement inclinée ; les figures 7 et 8 sont respectivement une vue en perspective et une vue en élévation d'une pince permettant de saisir l'accessoire ; la figure 9 est une vue en perspective de cette pince et d'un accessoire qu'elle saisit ; les figures 10, 11 et 12 montrent cet ensemble pince-accessoire respectivement suivant une vue en élévation prise du coté que l'on voit à droite sur la figure 9, une vue en élévation prise du coté qu'on y voit à gauche et une vue en plan prise de dessus ; - la figure 13 est une vue en perspective illustrant la pince, un porte-accessoire, un poussoir et l'accessoire dans une position de dépose sur le porte-accessoire ; la figure 14 est une vue en perspective montrant isolément le porte-accessoire ; la figure 15 est une vue en plan de dessus de l'accessoire, du porte-accessoire et du poussoir tels qu'on les voit sur la figure 13 mais où la pince, bien que présente, n'est pas illustrée pour la clarté du dessin ; la figure 16 est une vue similaire à la figure 15 mais où l'accessoire est plaqué par le poussoir contre le porte-accessoire dans sa position de butée ; la figure 17 est une vue en élévation prise du coté que l'on voit en bas sur la figure 16 ; les figures 18 et 19 sont respectivement une vue en perspective et une vue en élévation de la pince engagée dans un porte-pince ; les figures 20 et 21 sont respectivement une vue en perspective et une vue en élévation prise du coté qu'on voit à droite sur la figure 20 d'un dispositif de dégagement de l'accessoire hors de la pince ; la figure 22 est une vue schématique montrant comment coopèrent conformément à l'invention une paillette, un accessoire de remplissage, une buse d'aspiration, une pointe de pipette et un réceptacle disposé dans un porte-réceptacle dans une position où la pointe de pipette coopère avec le réceptacle contenant une substance liquide ; la figure 23 est une vue similaire à la figure 22 mais dans une position où la pointe de pipette est disposée au dessus de l'ouverture d'entrée de l'accessoire, après avoir prélevé dans le réceptacle une certaine quantité de substance liquide ; - la figure 24 est une vue similaire à la figure 22 mais dans une position où le contenu de la pointe de pipette a été transféré à l'accessoire ; la figure 25 est une vue similaire à la figure 22 mais dans une position où l'accessoire et la buse d'aspiration sont engagés à emboîtement étanche dans le tube de la paillette ; - la figure 26 est une vue similaire à la figure 22 mais dans une position où une dose prédéterminée de substance liquide est introduite dans le tube de la paillette ; et les figures 27 et 28 sont deux vues en élévation de deux autres modes de réalisation de l'accessoire dans lequel est reçu à emboîtement une pointe de pipette.• said spout is molded in one piece of rigid plastic material. The characteristics and advantages of the invention will emerge from the description which follows, given by way of a preferred but nonlimiting example, with reference to the appended drawings, in which: FIGS. 1 and 2 are two perspective views taken from two angles different in isolation presenting a filling accessory according to the invention; Figures 3, 4 and 5 show this accessory respectively in an elevational view taken from the side that is seen on the left in Figure 1, a top plan view and an elevational sectional view as shown in V-V on Figure 3; - Figure 6 is a view similar to Figure 5 illustrating a variant of this accessory in which the bottom wall is slightly inclined; Figures 7 and 8 are respectively a perspective view and an elevational view of a gripper for gripping the accessory; Figure 9 is a perspective view of this clamp and an accessory that it captures; FIGS. 10, 11 and 12 show this accessory-gripper assembly respectively according to an elevational view taken from the side which is seen on the right in FIG. 9, an elevational view taken from the side seen on the left and a plan view taken from above; - Figure 13 is a perspective view illustrating the clamp, an accessory holder, a pusher and the accessory in a removal position on the accessory holder; Figure 14 is a perspective view showing separately the accessory holder; FIG. 15 is a top plan view of the accessory, the accessory carrier and the pusher as seen in FIG. 13 but where the clip, although present, is not illustrated for the sake of clarity. drawing; Figure 16 is a view similar to Figure 15 but where the accessory is pressed by the pusher against the accessory holder in its abutment position; Figure 17 is an elevational view taken from the side shown below in Figure 16; Figures 18 and 19 are respectively a perspective view and an elevational view of the clamp engaged in a clip holder; Figures 20 and 21 are respectively a perspective view and an elevational view taken from the side shown to the right in Figure 20 of a device of release of the accessory out of the clamp; Fig. 22 is a schematic view showing how cooperates according to the invention a straw, a filling accessory, a suction nozzle, a pipette tip and a receptacle disposed in a receptacle holder in a position where the pipette tip cooperates with the receptacle containing a liquid substance; Figure 23 is a view similar to Figure 22 but in a position where the pipette tip is disposed above the inlet opening of the accessory, after taking from the receptacle a certain amount of liquid substance; - Figure 24 is a view similar to Figure 22 but in a position where the content of the pipette tip has been transferred to the accessory; Figure 25 is a view similar to Figure 22 but in a position where the accessory and the suction nozzle are engaged tightly in the tube of the flake; - Figure 26 is a view similar to Figure 22 but in a position where a predetermined dose of liquid substance is introduced into the tube of the straw; and Figures 27 and 28 are two elevational views of two further embodiments of the accessory in which a pipette tip is interlocked.
L'accessoire 1 illustré en figures 1 à 5 comporte un bec 2 et un corps 3. Le bec 2 est d'un seul bloc avec le corps 3 et fait saillie transversalement au corps.The accessory 1 illustrated in Figures 1 to 5 comprises a spout 2 and a body 3. The spout 2 is integral with the body 3 and protrudes transversely to the body.
Le bec 2 est formé d'une seule pièce moulée en matière plastique rigide et comporte un canal capillaire 4 s'étendant ici sur toute la longueur du bec 2 entre une première extrémité présentant un passage 5, par lequel le canal 4 communique avec l'espace délimité par le corps 3, et une seconde extrémité présentant un orifice de sortie 6.The spout 2 is formed of a single molded piece of rigid plastic material and comprises a capillary channel 4 extending here over the entire length of the spout 2 between a first end having a passage 5, through which the channel 4 communicates with the space defined by the body 3, and a second end having an outlet port 6.
Une première portion 7' du bec 2 présentant une surface extérieure tronconique 7" s'étend du corps 3 jusqu'à mi-longueur du bec 2 selon une section décroissante et se prolonge par une seconde portion 8' du bec présentant une surface extérieure cylindrique 8" s'étendant de la première portion T jusqu'à l'extrémité distale du bec 2.A first portion 7 'of the spout 2 having a frustoconical outer surface 7 "extends from the body 3 to mid-length of the spout 2 in a decreasing section and is extended by a second portion 8' of the spout having a cylindrical outer surface 8 "extending from the first portion T to the distal end of the spout 2.
La portion cylindrique 8' présente une dépouille d'environ 0,5°. Le corps 3 comporte une paroi tubulaire subdivisée en deux portions 9 et 10 par une paroi de fond 11. La portion 9 délimite avec la paroi 11 un réservoir pour contenir une substance liquide. Ce réservoir présente une ouverture d'entrée 12 à l'extrémité opposée à la paroi de fond 11. La portion 10 forme un embasement sur lequel prend appui l'accessoire.The cylindrical portion 8 'has a draft of approximately 0.5 °. The body 3 comprises a tubular wall subdivided into two portions 9 and 10 by a bottom wall 11. The portion 9 delimits with the wall 11 a reservoir for containing a liquid substance. This reservoir has an inlet opening 12 at the end opposite to the bottom wall 11. The portion 10 forms a base on which the support is supported.
La paroi de fond 11 est ici inclinée selon un angle de 30° par rapport au bec 2. Le canal capillaire 4 communique avec le corps 3 par le passage 5 dont la partie basse débouche à fleur de la partie la plus basse de la paroi de fond 11 du corps 3, soit au niveau le plus bas du réservoir.The bottom wall 11 is here inclined at an angle of 30 ° with respect to the spout 2. The capillary channel 4 communicates with the body 3 through the passage 5, the lower part of which opens out flush with the lower part of the wall. bottom 11 of the body 3, ie at the lowest level of the tank.
Le corps 3 est globalement orienté selon une direction transversale à l'orientation générale du bec 2, l'accessoire 1 présentant ainsi une forme générale coudée.The body 3 is generally oriented in a direction transverse to the general orientation of the spout 2, the accessory 1 thus having a generally bent shape.
A l'opposé du bec 2, le corps 3 comporte, sur sa face externe, une nervure rigide 13, d'un seul bloc avec le corps 3 et de forme générale parallélépipédique. Deux languettes 14 d'un seul bloc avec le corps 3 et diamétralement opposées l'une par rapport à l'autre, sont disposées sur la face externe du corps 3, à même niveau et à mi-distance entre la nervure 13 et le bec 2. Deux pattes 15 sont situées de part et d'autre de chaque languette 14. A l'aplomb de chaque languette 14, une encoche 16 est ménagée à l'extrémité du corps 3 bordant l'ouverture 12.Opposite the spout 2, the body 3 comprises, on its outer face, a rigid rib 13, a single block with the body 3 and generally parallelepipedal shape. Two tabs 14 of a single block with the body 3 and diametrically opposite one another, are arranged on the outer face of the body 3, at the same level and midway between the rib 13 and the beak 2. Two lugs 15 are located on either side of each tongue 14. In line with each tongue 14, a notch 16 is formed at the end of the body 3 bordering the opening 12.
On va maintenant décrire la variante 1 ' de l'accessoire illustré sur la figure 6. On a employé pour les éléments identiques les mêmes références que pour l'accessoire 1. L'accessoire l' est identique à l'accessoire 1 si ce n'est que la paroi de fond 11' du corps 3 présente une inclinaison plus faible, ici de 4,5° par rapport au bec 2.The variant 1 'of the accessory illustrated in FIG. 6 will now be described. The same references are used for the identical elements as for the accessory 1. The accessory is identical to the accessory 1 if it is that the bottom wall 11 'of the body 3 has a lower inclination, here of 4.5 ° with respect to the spout 2.
On va maintenant décrire à l'aide des figures 7 à 12 une pince permettant de manipuler l'accessoire avec un bras robotisé tel que le bras 95 (figures 18 à 21 ).7 to 12 will now be described a clamp for manipulating the accessory with a robotic arm such as the arm 95 (Figures 18 to 21).
La pince 30 permettant de saisir l'accessoire 1 comporte un corps central 31 et deux bras élastiquement déformables 34.The clamp 30 for grasping the accessory 1 comprises a central body 31 and two elastically deformable arms 34.
Le corps central 31 présente une forme générale parallélépipédique présentant deux faces carrées 32, et, s'étendant de l'un à l'autre de chaque coté des faces carrées, quatre faces rectangulaires semblables 33. Une des faces rectangulaires 33 présente en son centre un orifice de connexion 35 à un bras robotisé.The central body 31 has a generally parallelepipedal shape having two square faces 32, and extending from one to the other on each side of the square faces, four similar rectangular faces 33. One of the rectangular faces 33 has in its center a connection port 35 to a robotic arm.
Les deux bras 34 sont reliés transversalement à la face rectangulaire 33 opposée à celle présentant l'orifice 35. Chaque bras 34 présente un tronçon 36 de forme parallélépipédique et un crochet 37, dans le prolongement du tronçon 36 et en regard du crochet 37 de l'autre bras.The two arms 34 are connected transversely to the rectangular face 33 opposite that having the orifice 35. Each arm 34 has a section 36 of parallelepipedal shape and a hook 37, in the extension of the section 36 and opposite the hook 37 of the other arm.
Chaque crochet 37 présente une surface convexe 38 et une surface droite en renfoncement 39 par rapport au tronçon 36, une surface droite 40 reliant la surface convexe 38 à la surface en renfoncement 39 et une surface 41 reliant la surface en renfoncement 39 au tronçon 36. La jonction de la surface convexe 38 et de la surface droite 40 pointe vers l'autre crochet 37 tandis que la jonction entre la surface droite 40 et la surface en renfoncement 39 pointe vers le crochet 37 auquel elle appartient.Each hook 37 has a convex surface 38 and a recessed straight surface 39 with respect to the section 36, a straight surface 40 connecting the convex surface 38 to the recessed surface 39 and a surface 41 connecting the recessed surface 39 to the section 36. The junction of the convex surface 38 and the straight surface 40 points towards the other hook 37 while the junction between the straight surface 40 and the recessed surface 39 points towards the hook 37 to which it belongs.
La jonction de la surface en renfoncement 39 avec la surface 41 pointe vers le crochet 37 auquel elle appartient tandis que la jonction de cette surface 41 avec le tronçon 36 forme un épaulement 42.The junction of the recessed surface 39 with the surface 41 points towards the hook 37 to which it belongs while the junction of this surface 41 with the section 36 forms a shoulder 42.
On va maintenant décrire à l'aide des figures 13 à 17 le porte- accessoire 60 sur lequel vient prendre appui l'accessoire pendant l'étape de remplissage. Le porte-accessoire 60 comporte un socle 61 de forme générale parallélépipédique et deux pattes 62 saillant du socle 61.The accessory holder 60 on which the accessory comes to bear during the filling step will now be described with reference to FIGS. 13 to 17. The accessory holder 60 comprises a pedestal 61 of generally parallelepipedal shape and two tabs 62 projecting from the base 61.
Le socle 61 comporte deux faces principales rectangulaires 63, deux faces rectangulaires 64 s'étendant de l'un à l'autre des grands cotés des faces principales 63 et deux faces rectangulaires 65 s'étendant de l'un à l'autre des petits cotés des faces principales 63.The base 61 has two rectangular main faces 63, two rectangular faces 64 extending from one to the other of the long sides of the main faces 63 and two rectangular faces 65 extending from one to the other of the small sides of the main faces 63.
Une des faces 64 repose sur une plaque 70 appartenant à un chariot mobile qui n'est pas représenté davantage.One of the faces 64 rests on a plate 70 belonging to a movable carriage which is not represented further.
Les pattes 62 sont liées au socle 61 par l'autre face 64, en débord de celle-ci, dans le prolongement d'un angle entre une face 63 et une face 65. Les pattes 62 sont séparées l'une de l'autre pour une rainure 66 de profil tronconique dont la section est croissante de la face 65 la plus proche vers la face 65 la plus éloignée de la rainure 66.The tabs 62 are connected to the base 61 by the other face 64, beyond it, in the extension of an angle between a face 63 and a face 65. The tabs 62 are separated from each other for a groove 66 of frustoconical profile whose section is increasing from the face 65 closest to the face 65 farthest from the groove 66.
Chaque patte 62 a une section de forme générale triangulaire et présente sur sa face adjacente à la rainure 66 où la section est la plus large, un renfoncement en arc de cercle 67 dont le rayon de courbure est identique au rayon de courbure du corps 3 ainsi qu'un rebord 68 saillant dans le prolongement du renfoncement 67 du coté opposé à Ia rainure 66.Each tab 62 has a section of generally triangular shape and has on its face adjacent to the groove 66 where the section is the widest, a recess in a circular arc 67 whose radius of curvature is identical to the radius of curvature of the body 3 and a flange 68 protruding in the extension of the recess 67 on the opposite side to the groove 66.
On va maintenant décrire le poussoir 50 qui permet de faire glisser l'accessoire 1 de sa position de dépose par la pince 30 sur le porte-accessoire 60 jusqu'à sa position en butée contre le porte-accessoire 60 à l'aide de la figure 13 et des figures 15 à 17.We will now describe the pusher 50 which allows to slide the accessory 1 from its removal position by the clamp 30 on the accessory holder 60 to its position in abutment against the accessory holder 60 by means of the Figure 13 and Figures 15-17.
Le poussoir 50 comporte un presseur 53 et un vérin formé d'une tige 51 et d'un corps 52. La tige 51 est reliée à une extrémité au presseur 53 et à l'autre extrémité à un piston (non visible sur les dessins) mobile à l'intérieur du corps 52.The pusher 50 comprises a presser 53 and a jack formed of a rod 51 and a body 52. The rod 51 is connected at one end to the presser 53 and at the other end to a piston (not visible in the drawings) movable inside the body 52.
Le presseur 53 est ici de forme générale parallélépipédique. La face rectangulaire opposée à la face par laquelle il est lié à la tige 51 présente un renfoncement en arc de cercle 54 dont le rayon de courbure est identique au rayon de courbure du corps 3.Presser 53 is here of parallelepipedal general shape. The rectangular face opposite the face by which it is connected to the rod 51 has a recess in an arc of circle whose radius of curvature is identical to the radius of curvature of the body 3.
On va maintenant décrire les dispositifs annexes permettant de réaliser le cycle automatique de remplissage des paillettes, en particulier un porte-pince 80 servant à ranger la pince 30 lorsqu'elle n'est pas connectée au bras robotisé ainsi que des moyens de dégagement de l'accessoire 1 à la pinceWe will now describe the ancillary devices for carrying out the automatic filling cycle flakes, in particular a clamp holder 80 for storing the clamp 30 when not connected to the robotic arm and means for clearing the flange. 'accessory 1 to the clip
30.30.
Le porte-pince 80 illustré sur les figures 18 et 19 comporte un socle 88 de forme générale parallélépipédique présentant deux faces principales 81 et, s'étendant de l'un à l'autre des grands cotés des faces principales, deux faces rectangulaires semblables 82, et de l'un à l'autre des petits cotés des faces principales deux faces rectangulaires semblables 83. Le socle 88 comporte une cavité 87 débouchant sur une des faces 83 par une ouverture 84. Un ergot 85 commandé par un moteur 86 est logé dans la cavité 87. Le dispositif de dégagement de l'accessoire illustré sur les figures 20 et 21 comporte une tige 90 reliée transversalement à une paroi verticale fixe 91.The clamp holder 80 illustrated in FIGS. 18 and 19 comprises a base 88 of generally parallelepipedal shape having two main faces 81 and, extending from one to the other of the long sides of the main faces, two similar rectangular faces 82 , and from one to the other of the short sides of the main faces two similar rectangular faces 83. The base 88 has a cavity 87 opening on one of the faces 83 through an opening 84. A lug 85 controlled by a motor 86 is housed in the cavity 87. The release device of the accessory illustrated in FIGS. 20 and 21 comprises a rod 90 connected transversely to a fixed vertical wall 91.
Le bras robotisé 95, illustré sur les figures 18 à 21 , présente une tige de pipette 96 dont l'extrémité distale peut aussi bien, comme on le verra ci- après, être engagée dans l'orifice 35 de la pince 30 que dans une pointe de pipette 24. Le bras 95 comporte des moyens pneumatiques permettant de réaliser une dépression dans une pointe de pipette pour aspirer une substance liquide et permettant de supprimer la dépression dans la pointe de pipette pour libérer le liquide contenu dans la pointe de pipette.The robotic arm 95, illustrated in FIGS. 18 to 21, has a pipette rod 96, the distal end of which can, as will be seen below, be engaged in the orifice 35 of the clamp 30 as pipet tip 24. The arm 95 includes pneumatic means for performing a vacuum in a pipette tip to aspirate a liquid substance and to suppress the vacuum in the pipette tip to release the liquid contained in the pipette tip.
On va maintenant décrire les étapes manuelles à réaliser avant de procéder au remplissage automatique des paillettes.We will now describe the manual steps to perform before proceeding to automatic filling flakes.
Les réceptacles ouverts sur le dessus contenant les substances liquides à conditionner sont ici des tubes primaires 45 en verre (du genre tube à essai) préalablement disposés dans un porte-réceptacle 46 (figures 22 et 23) tel qu'un carrousel ou un râtelier à tubes primaires. Ce porte-réceptacle, distinct du porte-accessoire 60 préinstallé dans la machine, est chargé manuellement dans la machine avant le démarrage d'un cycle.The containers open on the top containing the liquid substances to be packaged here are primary tubes 45 of glass (of the test tube type) previously arranged in a receptacle holder 46 (FIGS. 22 and 23) such a carousel or rack with primary tubes. This receptacle holder, separate from the accessory holder 60 preinstalled in the machine, is manually loaded into the machine before starting a cycle.
Il en va de même pour le porte-pointe (ici un râtelier à pointes de pipette non représenté) et la boîte d'accessoires (ici un râtelier à accessoires non représenté) qui sont chargés également manuellement.It is the same for the tip holder (here a pipette tip rack not shown) and the accessory box (here an accessory rack not shown) which are also loaded manually.
Des paillettes vides 25 sont également disposées manuellement dans une trémie de distribution des paillettes non représentée sur les figures.Empty flakes 25 are also disposed manually in a glitter distribution hopper not shown in the figures.
Une buse d'aspiration 27, dont le remplacement n'est pas nécessaire par la suite car n'entrant pas en contact avec les liquides à conditionner, est fixée manuellement à un chariot mobile et est raccordée à une source de vide 29, de type pompe à vide, comme illustré en figures 22 à 26.A suction nozzle 27, the replacement of which is not necessary afterwards because it does not come into contact with the liquids to be conditioned, is manually fixed to a mobile carriage and is connected to a vacuum source 29, of a similar type. vacuum pump, as illustrated in Figures 22 to 26.
On va maintenant décrire les différentes étapes réalisées automatiquement permettant de conditionner des substances liquides dans des paillettes.We will now describe the various steps performed automatically to condition liquid substances in flakes.
Le bras robotisé 95, manipulable dans les trois dimensions de l'espace, est placé au dessus du porte-pince 80. Le bras robotisé 95 est descendu en direction du porte-pince 80, l'embout mâle de la tige de pipette 96 du bras 95 s'enclenche dans l'orifice 35 de la pince 30, comme montré sur les figures 18 et 19. Le moteur 86 est ensuite commandé pour rétracter l'ergot 85.The robotic arm 95, manipulable in the three dimensions of the space, is placed above the clamp holder 80. The robotic arm 95 is lowered towards the clamp holder 80, the male end of the pipette rod 96 of the arm 95 engages in the hole 35 of the clamp 30, as shown in FIGS. 18 and 19. The motor 86 is then controlled to retract the lug 85.
Le bras robotisé 95 muni de la pince 30 est ensuite déplacé au dessus du râtelier à accessoires (non représenté).The robotic arm 95 provided with the clamp 30 is then moved over the accessory rack (not shown).
Pour saisir un accessoire comme illustré sur les figures 9 à 12, le brasTo grab an accessory as shown in Figures 9 to 12, the arm
95 et la pince 30 sont placés au dessus de l'accessoire et sont abaissés. Les bras 34 de la pince 30 longent la face externe du corps 3 jusqu'à venir en appui contre les languettes 14 par la surface convexe 38. La surface convexe 38 à l'extrémité libre des crochets 37 tend à écarter les tronçons 36 jusqu'à ce que chaque languette 14 vienne s'engager dans un crochet 37. Par rappel élastique, les bras 34 de la pince 30 se referment autour des languettes 14 tandis que les épaulements 42 des bras 34 se logent dans les encoches 16 du corps 3 ménagées à cet effet.95 and the clamp 30 are placed above the accessory and are lowered. The arms 34 of the gripper 30 run along the external face of the body 3 until they bear against the tongues 14 by the convex surface 38. The convex surface 38 at the free end of the hooks 37 tends to move the sections 36 away from each other. each tongue 14 comes to engage a hook 37. By resilient return, the arms 34 of the clamp 30 close around the tongues 14 while the shoulders 42 of the arms 34 are housed in the notches 16 of the body 3 formed for this purpose.
Les pattes 15 placées de part et d'autre de chaque languette 14 ainsi que les encoches 16 empêchent tout mouvement de rotation du corps 3 autour de la pince 30, assurant le maintien en position de chaque languette 14 dans le crochet 37 respectif.The tabs 15 placed on either side of each tongue 14 as well as the notches 16 prevent any rotational movement of the body 3 around the clamp 30, ensuring the maintenance in position of each tab 14 in the respective hook 37.
L'accessoire saisi est déplacé du râtelier à accessoires (non représenté) jusqu'au dessus du porte-accessoire 60 puis il est engagé par le dessus dans le porte-accessoire 60 pour être déposé comme illustré en figure 13 sur la surface d'appui 64 du socle 61 du porte-accessoire 60. Le bec 2 est orienté par le bras robotisé 95 de façon à venir s'engager dans la rainure tronconique 66.The seized accessory is moved from the accessory rack (not shown) to the top of the accessory holder 60 and is engaged from above in the accessory holder 60 to be deposited as illustrated in FIG. 13 on the support surface. 64 of the base 61 of the accessory-holder 60. The spout 2 is oriented by the robotic arm 95 so as to engage in the frustoconical groove 66.
Le presseur 53 est alors déplacé pour venir au contact de l'accessoire afin que le renfoncement en arc de cercle 54 du presseur 53 vienne en appui contre la portion 9 de l'accessoire 1 du coté opposé au bec 2 grâce à quoi l'accessoire glisse horizontalement sur le porte-accessoire 60 de sa position de dépose, illustré en figures 13 et 15, à une position de butée contre les pattes 62 du porte-accessoire 60, illustrée en figures 16 et 17. Dans cette position de butée, la nervure 13 de l'accessoire 1 est située sous la surface inférieure 55 du presseur 53.The presser 53 is then moved to come into contact with the accessory so that the arcuate recess 54 of the presser 53 bears against the portion 9 of the accessory 1 on the side opposite the spout 2, whereby the accessory slides horizontally on the accessory-holder 60 of its removal position, illustrated in FIGS. 13 and 15, at an abutment position against the lugs 62 of the accessory-holder 60, illustrated in FIGS. 16 and 17. In this abutment position, the rib 13 of the accessory 1 is located under the lower surface 55 of the presser 53.
Au cours du déplacement de l'accessoire 1 , la portion tronconique T du bec 2 du porte-accessoire 60 est guidée par la rainure tronconique 66 grâce à quoi l'orifice de sortie 6 est disposé avec précision en regard et au centre de l'extrémité 21 du tube mince 20 d'une paillette 25 comme illustré en figure 22.During the displacement of the accessory 1, the frustoconical portion T of the spout 2 of the accessory holder 60 is guided by the frustoconical groove 66, whereby the outlet orifice 6 is precisely positioned opposite and in the center of the end 21 of the thin tube 20 of a straw 25 as illustrated in FIG.
La paillette 25 a quant à elle été amenée par un tapis transporteur non représenté dans Ia position illustrée, où elle doit être remplie.The straw 25 has been brought by a conveyor belt not shown in the illustrated position, where it must be filled.
L'embasement 10 permet d'orienter le canal capillaire 4 selon l'axe de la paillette 25 indépendamment de l'inclinaison de la paroi de fond 11 , grâce à quoi en position de butée sur le porte-accessoire 60, le canal capillaire 4 est parallèle et centré par rapport à la paillette 25. Le corps 3 est alors en position debout, tandis que le bec 2, orienté transversalement au corps 3 est comme la paillette 25 en position couchée.The embossment 10 makes it possible to orient the capillary channel 4 along the axis of the straw 25 independently of the inclination of the bottom wall 11, whereby in the abutment position on the accessory-holder 60, the capillary channel 4 is parallel and centered with respect to the flake 25. The body 3 is then in the upright position, while the spout 2, oriented transversely to the body 3 is like the straw 25 in the supine position.
Dans la position de butée (figures 16 et 17), le bec 2 est saillant au- delà des pattes 62 du porte-accessoire 60 tandis que chaque patte 15 de l'accessoire 1 la plus proche du bec 2 est logée sous le rebord 68 de la patte correspondante 62 du porte-accessoire 60. Lorsque l'accessoire est sollicité à arrachement vers le haut dans la position de butée chaque patte 15 du corps 3 la plus proche du bec 2 vient en butée contre le rebord saillant 68 respectif de la patte 62 du porte-accessoire 60 tandis que la nervure 13 du corps 3 vient en butée contre la surface inférieure 55 du presseur 53.In the stop position (Figures 16 and 17), the spout 2 protrudes beyond the legs 62 of the accessory holder 60 while each leg 15 of the accessory 1 closest to the spout 2 is housed under the flange 68 corresponding tab 62 of the accessory holder 60. When the accessory is biased upwards in the abutment position, each lug 15 of the body 3 closest to the nose 2 abuts against the respective protruding edge 68 of the lug 62 of the accessory holder 60 while the rib 13 of the body 3 abuts against the lower surface 55 of the presser 53.
Le bras robotisé 95 peut donc être remonté de façon à désengager élastiquement les languettes 14 de l'accessoire 1 des crochets 37 de la pinceThe robotic arm 95 can therefore be reassembled so as to elastically disengage the tongues 14 of the accessory 1 of the hooks 37 of the clamp
30, à l'inverse de l'opération d'engagement décrite précédemment, l'inclinaison de la surface droite 40 du crochet 37 par rapport à la languette 14 facilite le décrochage.30, unlike the engagement operation described above, the inclination of the straight surface 40 of the hook 37 relative to the tongue 14 facilitates the stall.
Le bras robotisé 95 repose ensuite la pince 30 dans le porte-pince 80. Le moteur 86 est ensuite commandé pour que l'ergot 85 appuie sur un des tronçons 36 de la pince 30 afin de la maintenir en position lorsque le bras est remonté pour être déconnecté de la pince 30. Le bras 95 est ensuite placé au dessus du râtelier (non représenté) à pointes de pipette afin d'enficher l'embout mâle de la tige de pipette 96 du bras robotisé 95 dans une pointe de pipette 24 (figures 22 et 23).The robotic arm 95 then rests the clamp 30 in the clamp holder 80. The motor 86 is then controlled so that the lug 85 presses on one of the sections 36 of the clamp 30 in order to hold it in position when the arm is reassembled to The arm 95 is then placed at the top of the pipette tip rack (not shown) in order to plug the male end of the pipette rod 96 of the robotic arm 95 into a pipette tip 24 (FIG. Figures 22 and 23).
Le bras robotisé 95 muni de la pointe de pipette 24 en position debout, est ensuite placé au dessus d'un des réceptacles 45 ouvert sur le dessus contenant la substance liquide à conditionner afin de faire coopérer la pointe de pipette 24 avec le réceptacle 45 par son ouverture 47 : l'extrémité distale de la pointe de pipette 24, en position debout, est plongée dans la substance liquide comme illustrée en figure 22.The robotic arm 95 provided with the pipette tip 24 in the upright position, is then placed above one of the open-top receptacles 45 containing the liquid substance to be conditioned in order to co-operate the pipette tip 24 with the receptacle 45. its opening 47: the distal end of the pipette tip 24, in the upright position, is immersed in the liquid substance as illustrated in FIG.
Une dépression est ensuite engendrée dans la pointe de pipette 24 afin qu'elle puisse aspirer une quantité 26 de substance liquide (figure 23), contenant au moins une dose prédéterminée 26' de substance liquide (figure 26).Depression is then generated in the pipette tip 24 so that it can aspirate an amount of liquid substance (Figure 23) containing at least a predetermined dose 26 'of liquid substance (Figure 26).
Le bras 95 muni de la pointe de pipette 24 remplie de la quantité de liquide 26 qu'elle contient est ensuite, ainsi que montré sur la figure 23, disposé au dessus du corps 3 de l'accessoire 1 , toujours en position de butée sur le porte-accessoire 60.The arm 95 provided with the pipette tip 24 filled with the quantity of liquid 26 that it contains is then, as shown in FIG. 23, disposed above the body 3 of the accessory 1, always in abutment position on the accessory holder 60.
La dépression est ensuite supprimée dans la pointe de pipette 24, toujours en position debout, pour que la quantité de liquide 26 soit libérée de la pointe de pipette 24 et soit recueillie dans le corps 3 de l'accessoire 1 comme montré sur la figure 24.The depression is then removed in the pipette tip 24, still in the upright position, so that the quantity of liquid 26 is released from the pipette tip 24 and is collected in the body 3 of the accessory 1 as shown in FIG. 24.
L'extrémité distale de la pointe de pipette 24 est ici placée au dessus de l'ouverture 12 mais il est également possible de la placer en-dessous, au sommet du réservoir de l'accessoire 1.The distal end of the pipette tip 24 is here placed above the opening 12 but it is also possible to place it below, at the top of the reservoir of the accessory 1.
Comme on le verra ultérieurement à l'appui des figures 27 et 28, d'autres modes de coopération entre une pointe de pipette 24 et un accessoire de remplissage sont possibles pour faire passer la substance liquide de la pointe de pipette 24 dans un accessoire de remplissage. Dans l'accessoire 1 , le canal capillaire 4 du bec 2 et le corps 3 sont dimensionnés de telle sorte que lorsque le corps 3 de l'accessoire est rempli, comme illustré en figures 24, et maintenu à pression atmosphérique, le canal 4 s'oppose par capillarité à la circulation de la substance liquide en l'absence de dépression, vu le viscosité de cette substance. Le liquide ne s'écoule donc pas au travers du conduit capillaire 4 tant que l'orifice de sortie 6 n'est pas soumis à une dépression.As will be seen later with the aid of FIGS. 27 and 28, other modes of cooperation between a pipette tip 24 and a filling accessory are possible for passing the liquid substance from the pipette tip 24 into a dispensing accessory. filling. In the accessory 1, the capillary channel 4 of the spout 2 and the body 3 are dimensioned so that when the body 3 of the accessory is filled, as illustrated in FIG. 24, and maintained at atmospheric pressure, the channel 4 is 'opposes by capillarity to the circulation of the liquid substance in the absence of depression, given the viscosity of this substance. The liquid does not flow through the capillary duct 4 as the outlet port 6 is not subjected to a depression.
La paillette 25 illustrée sur les figures 22 à 26 est disposée sur un tapis transporteur non illustré, et plus précisément dans un groupe d'encoches calibrées où elle a été engagée automatiquement à partir d'une trémie, le tapis présentant une succession régulière de groupes d'encoches, les paillettes mises en place sur le tapis étant perpendiculaires au sens d'avance de celui-ci.The straw 25 illustrated in FIGS. 22 to 26 is disposed on an unillustrated conveyor belt, and more precisely in a group of calibrated notches where it has been automatically engaged from a hopper, the carpet having a regular succession of groups. of notches, the straws placed on the carpet being perpendicular to the direction of advance thereof.
Pendant les opérations illustrées sur les figures 22 à 26, le tapis transporteur est à l'arrêt et l'extrémité 21 du tube mince 20 de la paillette 25 est en regard de la rainure 66 du porte-accessoire 60, présent mais non illustré sur les figures 22 à 26, tandis que l'extrémité 22 est disposée en regard de la buse d'aspiration 27 reliée à une source de vide 29 comme illustré en figure 22.During the operations illustrated in Figures 22 to 26, the conveyor belt is stopped and the end 21 of the thin tube 20 of the straw 25 is opposite the groove 66 of the accessory holder 60, present but not shown on Figures 22 to 26, while the end 22 is disposed facing the suction nozzle 27 connected to a vacuum source 29 as shown in Figure 22.
Les chariots (non illustrés) sur lesquels sont montés respectivement la buse d'aspiration 27 et l'accessoire 1 sont mobiles à translation transversalement au tapis transporteur, c'est-à-dire suivant la direction de la paillette 25. Ils réalisent des mouvements de va-et-vient entre une position rétractée et une position de travail. L'accessoire 1 est déposé dans le porte- accessoire 60 alors que le chariot qui le porte est en position rétractée. Lors du déplacement des chariots de leur position rétractée à leur position de travail, les chariots avancent vers la paillette 25 et le bec 2 ainsi que la buse 27 pénètrent chacun dans le tube 20. En position de travail, la surface 7" du bec 2 faisant saillie par rapport aux pattes 62 (figures 16 et 17) est engagée à emboîtement étanche dans l'extrémité 21 du tube 20 et la surface 28 de la buse d'aspiration 27 est engagée dans l'extrémité 22, comme illustré en figure 25.The trolleys (not shown) on which the suction nozzle 27 and the accessory 1 are mounted respectively are movable in translation transversely to the conveyor belt, that is to say in the direction of the straw 25. They perform movements back and forth between a retracted position and a work position. The accessory 1 is deposited in the accessory holder 60 while the carriage which carries it is in the retracted position. When moving the carriages from their retracted position to their working position, the carriages advance towards the straw 25 and the spout 2 and the nozzle 27 each enter the tube 20. In the working position, the surface 7 "of the spout 2 protruding from the tabs 62 (Figures 16 and 17) is engaged sealingly in the end 21 of the tube 20 and the surface 28 of the suction nozzle 27 is engaged in the end 22, as shown in Figure 25 .
La nature souple de la matière plastique formant le tube 20 permet d'assurer une bonne étanchéité avec le bec 2 même si celui-ci est réalisé en matière plastique rigide. Le plan de joint du moule de l'accessoire 1 est ici disposé à l'écart de la paroi 7" de façon à ne pas perturber la coopération étanche de la paillette 25 avec la surface tronconique 7".The flexible nature of the plastic forming the tube 20 ensures a good seal with the spout 2 even if it is made of rigid plastic material. The joint plane of the mold of the accessory 1 is here disposed away from the wall 7 "so as not to disturb the sealed cooperation of the flake 25 with the frustoconical surface 7".
La source de vide 29 engendre ensuite dans la paillette 25 une dépression dont il résulte l'écoulement d'une dose prédéterminée 26' de substance liquide du réservoir de l'accessoire 1 jusqu'au tube 20 via le canal capillaire 4.The vacuum source 29 then generates a depression in the straw 25 which results in the flow of a predetermined dose 26 'of liquid substance from the reservoir of the accessory 1 to the tube 20 via the capillary channel 4.
On observera que la substance liquide transitant par l'accessoire 1 y pénètre par l'ouverture d'entrée 12 et en sort par l'orifice de sortie 6.It will be observed that the liquid substance passing through the accessory 1 penetrates through the inlet opening 12 and exits through the outlet orifice 6.
La paroi de fond inclinée 11 facilite l'écoulement du fluide et évite ou en tout cas limite les phénomènes de turbulences engendrés par des changements de direction trop brutaux.The inclined bottom wall 11 facilitates the flow of the fluid and avoids or in any case limits the turbulence phenomena caused by sudden changes in direction.
Le bouchon composite 23 de la paillette 25 reste perméable à l'air tant que la poudre 23', incluse entre les deux tampons poreux 23", n'a pas gélifié par contact avec un liquide aqueux, en l'occurrence la substance liquide biologique à conditionner.The composite plug 23 of the straw 25 remains permeable to air as long as the powder 23 ', included between the two porous pads 23 ", has not gelled by contact with an aqueous liquid, in this case the liquid biological substance. to condition.
A la fin de l'étape de remplissage (figures 25 et 26), le bouchon composite 23 est donc imperméable.At the end of the filling step (FIGS. 25 and 26), the composite plug 23 is therefore impervious.
Les chariots sont ensuite entraînés vers la position rétractée et la paillette remplie est donc libérée du bec 2 et de la buse 27. La substance liquide résiduelle 26" contenue dans le réservoir après remplissage de la paillette ne s'écoule pas au travers du canal capillaire 4 pour les mêmes raisons qu'exposées précédemment. Le tapis est ensuite avancé pour placer une nouvelle paillette 25 à remplir en position de remplissage et pour placer la paillette remplie en position de soudure de ses extrémités.The carriages are then driven to the retracted position and the filled straw is thus released from the spout 2 and the nozzle 27. The residual liquid substance 26 "contained in the reservoir after filling the straw does not flow through the capillary channel. 4 for the same reasons as previously stated. The carpet is then advanced to place a new straw 25 to fill in the filling position and to place the filled straw in the welding position of its ends.
La même étape de remplissage est reproduite pour chaque paillette. En fonction de la quantité de liquide délivrée dans le corps 3 de l'accessoire 1 et de la quantité de liquide à conditionner dans la paillette 25, chaque accessoire 1 peut remplir une ou plusieurs paillettes 25. L'accessoire peut également être rempli une ou plusieurs fois par le bras robotisé 95.The same filling step is reproduced for each straw. Depending on the quantity of liquid delivered into the body 3 of the accessory 1 and the quantity of liquid to be packaged in the straw 25, each accessory 1 may fill one or more sequins 25. The accessory may also be filled one or several times by the robotic arm 95.
Lorsqu'on passe d'une substance liquide à une autre, pour éviter les risques de contamination, on remplace les éléments ayant été en contact avec la substance liquide précédente : en l'occurrence la pointe de pipette 24 et l'accessoire 1.When switching from one liquid substance to another, to avoid the risk of contamination, replace the elements that have been in contact with the previous liquid substance: in this case the pipette tip 24 and the accessory 1.
Le remplacement de la pointe de pipette 24 est bien connu et s'opère classiquement par éjection de la pointe 24 usagée hors de la tige de pipette 96 au dessus d'un récipient de stockage des consommables usagés et par emboîtement de l'élément de connexion mâle de la tige de pipette 96 du bras robotisé 95 dans une nouvelle pointe de pipette 24 disposée dans le porte- pointe.The replacement of the pipette tip 24 is well known and is conventionally effected by ejecting the used tip 24 out of the pipette rod 96 over a container for storing used consumables and by fitting the connection element. male of the pipette rod 96 of the robotic arm 95 into a new pipette tip 24 disposed in the tip holder.
Pour remplacer l'accessoire 1 usagé, l'accessoire 1 est saisi par le bras robotisé 95 muni de la pince 30 après que le presseur ait reculé pour revenir à la position qu'il occupait lorsque l'accessoire était dans la position de dépose.To replace the used accessory 1, the accessory 1 is grasped by the robotic arm 95 provided with the clamp 30 after the presser has moved back to the position it occupied when the accessory was in the removal position.
La pince 30 munie de l'accessoire 1 est dirigée vers le dispositif de dégagement afin de placer la tige 90 entre le corps central 31 de la pince 30 et l'accessoire 1 , de part et d'autre des tronçons 36 (figures 20 et 21 ).The clamp 30 provided with the accessory 1 is directed towards the release device in order to place the rod 90 between the central body 31 of the clamp 30 and the accessory 1, on either side of the sections 36 (FIGS. 21).
Au cours de la remontée du bras robotisé 95, la tige 90 vient appuyer contre le corps 3 de l'accessoire 1 qui est ainsi désolidarisé de la pince 30 et tombe dans le récipient de stockage des consommables usagés.During the ascent of the robotic arm 95, the rod 90 bears against the body 3 of the accessory 1 which is thus disengaged from the clamp 30 and falls into the used consumables storage container.
La pince 30 est alors disponible pour saisir un nouvel accessoire 1 dans le râtelier à accessoires.The clamp 30 is then available to enter a new accessory 1 in the accessory rack.
Un bras robotisé standard, par exemple de la marque TECAN, convient pour le bras 95. Dans un autre mode de réalisation illustré sur la figure 27, l'accessoire 101 comporte un corps 103 présentant une paroi tronconique et comporte un bec 102 faisant saillie transversalement au corps 103. La corps 103 s'étend entre une ouverture d'entrée 112 et une paroi de fond 111. Le bec 102 comporte une portion cylindrique 108', dont une extrémité se raccorde par emboîtement dans le corps 103, et une pastille 107' rapportée sur la portion cylindrique 108' et présentant une surface tronconique 107". Un canal capillaire 104 ménagé dans la portion cylindrique 108' s'étend d'un orifice de sortie 106 jusqu'à un passage 105 par lequel le canal capillaire 104 communique avec l'espace délimité par le corps 103.A standard robotic arm, for example of the TECAN brand, is suitable for the 95 arm. In another embodiment illustrated in FIG. 27, the accessory 101 comprises a body 103 having a frustoconical wall and comprises a spout 102 projecting transversely to the body 103. The body 103 extends between an inlet opening 112 and a bottom wall 111. The spout 102 has a cylindrical portion 108 ', one end of which is connected by interlocking in the body 103, and a pellet 107' attached to the cylindrical portion 108 'and having a frustoconical surface 107 ". capillary 104 formed in the cylindrical portion 108 'extends from an outlet port 106 to a passage 105 through which the capillary channel 104 communicates with the space delimited by the body 103.
Dans un autre mode de réalisation illustré sur la figure 28, l'accessoire 201 est similaire à l'accessoire 101 à la différence que le bec 202 de l'accessoire 201 est formé d'un seul bloc avec le corps 203 présentant également une paroi tronconique. Les accessoires 101 et 201 s'utilisent comme l'accessoire 1 à la différence qu'ils coopèrent en liaison mécanique avec la pointe de pipette 24 puisqu'elle est reçue à emboîtement dans la portion tronconique du corps 103 ou 203 au travers de l'ouverture d'entrée 112 ou 212.In another embodiment illustrated in FIG. 28, the accessory 201 is similar to the accessory 101 with the difference that the nozzle 202 of the accessory 201 is formed in one piece with the body 203 also having a wall truncated. The accessories 101 and 201 are used as the accessory 1 with the difference that they cooperate in mechanical connection with the pipette tip 24 since it is received interlocking in the frustoconical portion of the body 103 or 203 through the entrance opening 112 or 212.
Ces deux modes de réalisation permettent de manipuler l'accessoire sans utiliser une pince spécifique ou encore d'engager le bec 102 ou 202 dans le tube mince d'une paillette sans utiliser ni presseur ni porte-accessoire, puisque l'accessoire dans le cas présent peut être manipulé uniquement par le bras robotisé 95 par l'intermédiaire de la pointe de pipette 24 dans laquelle il est emboîté. Dans une variante non représentée, l'accessoire de remplissage 101 ou 201 est muni, comme l'accessoire 1 , des divers éléments permettant la coopération avec une pince telle que la pince 30, en l'occurrence une nervure telle que 13, des languettes et pattes telles que 14 et 15 et des encoches telles que 16. Dans une variante non représentée, l'accessoire de remplissage 101 ou 201 est muni, comme l'accessoire 1 , d'un bec tel que 2 comportant une portion cylindrique et une portion tronconique telles que 8' et T. Dans une autre variante non représentée, l'accessoire de remplissage 1 est muni, comme l'accessoire 101 d'un bec tel que 102 comportant une portion cylindrique telle que 108' sur laquelle est rapportée une pastille tronconique telle que 107'. Dans d'autres variantes, la paroi de fond 11 de l'accessoire 1 peut être incliné d'un angle compris entre 25° et 35° par rapport au bec 2.These two embodiments make it possible to manipulate the accessory without using a specific clamp or to engage the spout 102 or 202 in the thin tube of a straw without using either a presser or an accessory holder, since the accessory in the case present can be manipulated only by the robotic arm 95 through the pipette tip 24 in which it is fitted. In a variant not shown, the filling accessory 101 or 201 is provided, as the accessory 1, various elements for cooperation with a clamp such as the clamp 30, in this case a rib such as 13, tongues and tabs such as 14 and 15 and notches such as 16. In a variant not shown, the filling accessory 101 or 201 is provided, as the accessory 1, a nozzle such as 2 having a cylindrical portion and a frustoconical portion such as 8 'and T. In another variant not shown, the filling accessory 1 is provided, as the accessory 101 of a spout such as 102 having a cylindrical portion such as 108 'on which is reported a frustoconical pellet such as 107'. In other variants, the bottom wall 11 of the accessory 1 can be inclined at an angle of between 25 ° and 35 ° relative to the spout 2.
Dans d'autres variantes la paroi de fond 11 ' de l'accessoire 1 ' peut être inclinée d'un angle compris entre 2,5° et 6,5° par rapport au bec 2.In other variants, the bottom wall 11 'of the accessory 1' can be inclined at an angle of between 2.5 ° and 6.5 ° with respect to the spout 2.
Dans encore d'autres variantes non représentées, le canal que comporte le bec de l'accessoire n'est pas capillaire sur toute la longueur du bec mais seulement sur une portion située au voisinage de l'orifice de sortie pour empêcher l'écoulement spontané du liquide au travers du bec.In still other variants not shown, the channel that includes the nozzle of the accessory is not capillary over the entire length of the nozzle but only on a portion located in the vicinity of the outlet to prevent spontaneous flow liquid through the spout.
La présente invention n'est pas limitée aux modes de réalisation décrits et représentés mais englobe toute variante d'exécution. The present invention is not limited to the embodiments described and shown but encompasses any variant embodiment.

Claims

REVENDICATIONS
1. Procédé pour conditionner dans une paillette (25) une dose prédéterminée (26') de substance liquide initialement contenue dans un réceptacle (45) ouvert sur le dessus, comportant une étape de remplissage pour faire pénétrer ladite dose prédéterminée (26') dans ladite paillette (25), disposée en position couchée, avec un accessoire (1 ; 1 ' ; 101 ; 201 ) de remplissage emboîté dans ladite paillette, lequel procédé est caractérisé en ce qu'il comporte, préalablement à l'étape de remplissage : - l'étape de faire coopérer une pointe de pipette, en position debout, (24) avec ledit réceptacle (45) pour y prélever au moins une dite dose (26') de substance liquide ; l'étape de se procurer un dit accessoire présentant un corps (3 ; 103 ; 203) adapté à coopérer avec ladite pointe de pipette (24), en position debout, et présentant un bec (2 ; 102 ; 202) à canal capillaire (4 ; 104 ; 204) adapté à être emboîté dans ladite paillette (25), lequel bec est orienté transversalement audit corps (3 ; 103 ; 203) de sorte que quand ledit corps (3 ; 103 ; 203) est en position debout ledit bec (2 ; 102 ; 202) est en position couchée ; et - l'étape de faire coopérer ladite pointe de pipette, en position debout, (24) contenant au moins ladite dose (26'), avec ledit corps (3 ; 103 ; 203) pour que le contenu de ladite pointe de pipette (26) appartienne à cet accessoire (1 ; l' ; 101 ; 201 ).1. Method for packaging in a straw (25) a predetermined dose (26') of liquid substance initially contained in a receptacle (45) open on the top, comprising a filling step to penetrate said predetermined dose (26') into said straw (25), arranged in the lying position, with a filling accessory (1; 1 '; 101; 201) fitted into said straw, which method is characterized in that it comprises, prior to the filling step: - the step of making a pipette tip, in an upright position, (24) cooperate with said receptacle (45) to take at least one said dose (26') of liquid substance; the step of obtaining said accessory having a body (3; 103; 203) adapted to cooperate with said pipette tip (24), in an upright position, and having a nozzle (2; 102; 202) with a capillary channel ( 4; 104; 204) adapted to be fitted into said straw (25), which spout is oriented transversely to said body (3; 103; 203) so that when said body (3; 103; 203) is in a standing position said spout (2; 102; 202) is in a lying position; and - the step of making said pipette tip, in a standing position, (24) containing at least said dose (26'), cooperate with said body (3; 103; 203) so that the contents of said pipette tip ( 26) belongs to this accessory (1; l'; 101; 201).
2. Procédé selon la revendication 1 , caractérisé en ce qu'il comporte en outre, préalablement à l'étape de remplissage : l'étape de mettre en place l'accessoire (1 ; l') dans un porte- accessoire (60) appartenant à un chariot mobile (70) alors que celui-ci est dans une position rétractée ; et l'étape de déplacer le chariot (70) de ladite position rétractée à une position de travail pour emboîter de façon étanche ledit accessoire (1 ; l') dans ladite paillette (25). 2. Method according to claim 1, characterized in that it further comprises, prior to the filling step: the step of placing the accessory (1; l') in an accessory holder (60) belonging to a mobile carriage (70) while the latter is in a retracted position; and the step of moving the carriage (70) from said retracted position to a working position to sealingly fit said accessory (1; l') into said straw (25).
3. Procédé selon l'une quelconque des revendications 1 ou 2, caractérisé en ce qu'il comporte préalablement à l'étape de faire coopérer ladite pointe de pipette (24) avec ledit réceptacle (45) : l'étape d'emboîter ladite pointe de pipette (24) dans une pipette (95) ; tandis que l'étape de faire coopérer ladite pointe de pipette (24) avec ledit réceptacle (45) comporte : l'étape de disposer ladite pipette (95) munie de ladite pointe de pipette (24) au dessus dudit réceptacle (45) ; - l'étape de plonger l'extrémité de ladite pointe de pipette (24) dans ladite substance liquide contenue dans ledit réceptacle (45) ; et l'étape de créer une dépression dans ladite pointe de pipette (24) pour aspirer ladite substance liquide.3. Method according to any one of claims 1 or 2, characterized in that it comprises, prior to the step of making said pipette tip (24) cooperate with said receptacle (45): the step of fitting said pipette tip (24) in a pipette (95); while the step of making said pipette tip (24) cooperate with said receptacle (45) comprises: the step of placing said pipette (95) provided with said pipette tip (24) above said receptacle (45); - the step of immersing the end of said pipette tip (24) into said liquid substance contained in said receptacle (45); and the step of creating a vacuum in said pipette tip (24) to aspirate said liquid substance.
4. Procédé selon l'une quelconque des revendications 1 à 3, caractérisé en ce que l'étape de faire coopérer ladite pointe de pipette (24) contenant au moins ladite dose (26') avec ledit accessoire (1 ; l' ; 101 ; 201) comporte : l'étape de disposer ladite pointe de pipette (24) contenant au moins ladite dose (26') au dessus dudit accessoire (1 ; l' ; 101 ; 201 ) ; et - l'étape de supprimer la dépression dans ladite pointe de pipette4. Method according to any one of claims 1 to 3, characterized in that the step of making said pipette tip (24) containing at least said dose (26') cooperate with said accessory (1; l'; 101 ; 201) comprises: the step of placing said pipette tip (24) containing at least said dose (26') above said accessory (1; l'; 101; 201); and - the step of removing the depression in said pipette tip
(24) pour libérer le contenu de ladite pointe de pipette (24).(24) to release the contents of said pipette tip (24).
5. Procédé selon l'une quelconque des revendications 1 à 4, caractérisé en ce que : l'étape de faire coopérer ladite pointe de pipette, en position debout, (24) avec ledit réceptacle (45) pour y prélever ladite dite dose (26') de substance liquide ; et l'étape de faire coopérer ladite pointe de pipette, en position debout, (24) contenant au moins ladite dose (26'), avec ledit accessoire (1 ; l' ; 101 ; 201 ) pour que le contenu de ladite pointe de pipette (26) appartienne à cet accessoire (1 ; l' ; 101 ; 201) sont réalisées automatiquement.5. Method according to any one of claims 1 to 4, characterized in that: the step of making said pipette tip, in an upright position, (24) cooperate with said receptacle (45) to take said said dose ( 26') of liquid substance; and the step of making said pipette tip, in a standing position, (24) containing at least said dose (26'), cooperate with said accessory (1; l'; 101; 201) so that the contents of said tip of pipette (26) belonging to this accessory (1; l'; 101; 201) are carried out automatically.
6. Procédé selon la revendication 5, caractérisé en ce qu'il comporte, préalablement auxdites étapes réalisées automatiquement : l'étape de mettre en place manuellement une boîte à accessoires comportant ledit accessoire (1 ; V ; 101 ; 201) ; l'étape de mettre en place manuellement un porte-réceptacle (46) comportant ledit réceptacle (45) ; et - l'étape de mettre en place manuellement un porte-pointe comportant ladite pointe de pipette (24).6. Method according to claim 5, characterized in that it comprises, prior to said steps carried out automatically: the step of manually setting up an accessory box comprising said accessory (1; V; 101; 201); the step of manually setting up a receptacle holder (46) comprising said receptacle (45); and - the step of manually putting in place a tip holder comprising said pipette tip (24).
7. Procédé selon la revendication 6, caractérisé en ce que l'on sélectionne comme boîte à accessoires un râtelier à accessoires.7. Method according to claim 6, characterized in that an accessory rack is selected as the accessory box.
8. Procédé selon l'une quelconque des revendications 6 ou 7, caractérisé en ce que l'on sélectionne comme porte-pointe un râtelier à pointes de pipette.8. Method according to any one of claims 6 or 7, characterized in that a pipette tip rack is selected as the tip holder.
9. Procédé selon l'une quelconque des revendications 6 à 8, caractérisé en ce que l'on sélectionne comme porte-réceptacle (46) un râtelier à réceptacles. 9. Method according to any one of claims 6 to 8, characterized in that a receptacle rack is selected as receptacle holder (46).
10. Procédé selon l'une quelconque des revendications 6 à 8, caractérisé en ce que l'on sélectionne comme porte-réceptacle (46) un carrousel à réceptacles.10. Method according to any one of claims 6 to 8, characterized in that a receptacle carousel is selected as receptacle holder (46).
11. Procédé selon l'une quelconque des revendications 1 à 10, pour conditionner dans une paillette (25) une dose prédéterminée (26') de substance liquide initialement contenue dans un réceptacle (45) ouvert sur le dessus, comportant une étape de remplissage pour faire pénétrer ladite dose prédéterminée (26') dans ladite paillette (25), disposée en position couchée, avec un accessoire (1 ; l' ; 101 ; 201 ) de remplissage emboîté dans ladite paillette, lequel accessoire est initialement disposé dans une boîte à accessoires, lequel procédé est caractérisé en ce qu'il comporte, préalablement à l'étape de remplissage : l'étape de déplacer ledit accessoire (1 ; l') de ladite boîte à accessoires jusqu'au dessus d'un porte-accessoire (60) ; l'étape d'engager par le dessus ledit accessoire (1 ; 1 ') dans ledit porte-accessoire (60) pour le déposer ; et l'étape de faire glisser horizontalement ledit accessoire (1 ; l') par rapport audit porte-accessoire (60) d'une position de dépose sur ledit porte- accessoire (60) jusqu'à une position de butée contre ledit porte-accessoire (60). 11. Method according to any one of claims 1 to 10, for packaging in a straw (25) a predetermined dose (26') of liquid substance initially contained in a receptacle (45) open on the top, comprising a filling step to penetrate said predetermined dose (26') into said straw (25), arranged in the lying position, with a filling accessory (1; l';101; 201) fitted into said straw, which accessory is initially placed in a box accessories, which method is characterized in that it comprises, prior to the filling step: the step of moving said accessory (1; l') from said accessory box to the top of an accessory holder (60); the step of engaging said accessory (1; 1 ') from above into said accessory holder (60) to deposit it; and the step of sliding said accessory (1; l') horizontally relative to said accessory holder (60) from a position of placement on said accessory holder (60) to a position of abutment against said holder accessory (60).
12. Procédé selon la revendication 11 , caractérisé en ce que l'étape de déplacer ledit accessoire (1 ; l') comporte : l'étape de se procurer une pince (30) ; l'étape de saisir par ladite pince (30) ledit accessoire (1 ; 1 ') dans 5 ladite boîte à accessoires ; et l'étape de disposer ladite pince (30) munie dudit accessoire (1 ; l') au dessus dudit porte-accessoire (60).12. Method according to claim 11, characterized in that the step of moving said accessory (1; l') comprises: the step of obtaining a clamp (30); the step of grasping by said pliers (30) said accessory (1; 1 ') in said accessory box; and the step of placing said clamp (30) provided with said accessory (1; l') above said accessory holder (60).
13. Procédé selon l'une quelconque des revendications 11 ou 12, caractérisé en ce que l'étape de faire glisser ledit accessoire (1 ; l') comporte13. Method according to any one of claims 11 or 12, characterized in that the step of sliding said accessory (1; l') comprises
1.0 l'étape de déplacer un poussoir (50) plaqué contre ledit accessoire (1 ; 1 ').1.0 the step of moving a pusher (50) pressed against said accessory (1; 1 ').
14. Dispositif convenant à la mise en œuvre du procédé selon l'une quelconque des revendications 1 à 13, comportant un accessoire (1 ; l' ; 101 ; 201 ) adapté à être emboîtée dans une paillette (25) en position couchée pour y introduire une dose prédéterminée (26') de substance liquide initialement14. Device suitable for implementing the method according to any one of claims 1 to 13, comprising an accessory (1; l'; 101; 201) adapted to be fitted into a straw (25) in the lying position for introduce a predetermined dose (26') of liquid substance initially
15 contenue dans un réceptacle (45) ouvert sur le dessus, caractérisé en ce que ledit accessoire présente un corps (3 ; 103 ; 203) adapté à coopérer avec une pointe de pipette (24) en position debout pour que le contenu de ladite pointe de pipette (24) appartienne à cet accessoire (1 ; l' ; 101 ; 201 ), et présente un bec (2 ; 102 ; 202) à canal capillaire (4 ; 104 ; 204) adapté à être emboîté dans ladite15 contained in a receptacle (45) open on the top, characterized in that said accessory has a body (3; 103; 203) adapted to cooperate with a pipette tip (24) in the upright position so that the contents of said tip pipette (24) belongs to this accessory (1; l'; 101; 201), and has a nozzle (2; 102; 202) with capillary channel (4; 104; 204) adapted to be fitted into said
20 paillette, orienté transversalement audit corps de sorte que quand ledit corps est en position debout ledit bec (2 ; 102 ; 202) est en position couchée.20 straw, oriented transversely to said body so that when said body is in a standing position, said beak (2; 102; 202) is in a lying position.
15. Dispositif selon la revendication 14, caractérisé en ce que ledit corps (3 ; 103 ; 203) comporte une paroi de fond (11 ; 11 ' ; 111 ; 211 ).15. Device according to claim 14, characterized in that said body (3; 103; 203) comprises a bottom wall (11; 11 '; 111; 211).
16. Dispositif selon la revendication 15, caractérisé en ce que ladite 25 paroi de fond (11) est inclinée d'un angle compris entre 25° et 35° par rapport audit bec (2).16. Device according to claim 15, characterized in that said bottom wall (11) is inclined at an angle between 25° and 35° relative to said nozzle (2).
17. Dispositif selon la revendication 15, caractérisé en ce que ladite paroi de fond (11') est inclinée d'un angle compris entre 2,5° et 6,5° par rapport audit bec (2).17. Device according to claim 15, characterized in that said bottom wall (11') is inclined at an angle of between 2.5° and 6.5° relative to said nozzle (2).
30 18. Dispositif selon l'une quelconque des revendications 14 à 17, caractérisé en ce que ledit bec (3 ; 103 ; 203) comporte ledit canal capillaire (4 ; 104 ; 204) sur toute sa longueur. 18. Device according to any one of claims 14 to 17, characterized in that said nozzle (3; 103; 203) comprises said capillary channel (4; 104; 204) over its entire length.
19. Dispositif selon la revendication 18, caractérisé en ce que ledit corps (3 ; 103 ; 203) comporte une paroi de fond (11 ; 11 ' ; 111 ; 211 ) et en ce que ledit canal capillaire (2 ; 102 ; 202) s'étend d'un orifice de sortie (6 ; 106 ; 206) jusqu'à un passage (5 ; 105 ; 205) qui communique avec un espace délimité par ledit corps (3 ; 103 ; 203) et ladite paroi de fond (11 ; 11' ; 111 ; 211 ).19. Device according to claim 18, characterized in that said body (3; 103; 203) comprises a bottom wall (11; 11 '; 111; 211) and in that said capillary channel (2; 102; 202) extends from an outlet orifice (6; 106; 206) to a passage (5; 105; 205) which communicates with a space delimited by said body (3; 103; 203) and said bottom wall ( 11; 11'; 111; 211).
20. Dispositif selon la revendication 19, caractérisé en ce que la partie basse dudit passage (5 ; 105 ; 205) est à fleur de la partie la plus basse de ladite paroi de fond (11 ; 11 ' ; 111 ; 211 ) dudit corps (3 ; 103 ; 203). 20. Device according to claim 19, characterized in that the lower part of said passage (5; 105; 205) is flush with the lowest part of said bottom wall (11; 11'; 111; 211) of said body (3; 103; 203).
21. Dispositif selon l'une quelconque des revendications 14 à 20, caractérisé en ce que ledit bec (3) comporte une portion cylindrique (8') et une portion tronconique (7').21. Device according to any one of claims 14 to 20, characterized in that said nozzle (3) comprises a cylindrical portion (8') and a frustoconical portion (7').
22. Dispositif selon l'une quelconque des revendications 14 à 20, caractérisé en ce que ledit bec (103 ; 203) comporte une portion cylindrique (108' ; 208') et une pastille tronconique (107' ; 207') rapportée sur ladite portion cylindrique (108', 208').22. Device according to any one of claims 14 to 20, characterized in that said nozzle (103; 203) comprises a cylindrical portion (108'; 208') and a frustoconical pellet (107'; 207') attached to said cylindrical portion (108', 208').
23. Dispositif selon l'une quelconque des revendications 14 à 22, caractérisé en ce que ledit corps (3) comporte une paroi de fond (11 ; 11') et une paroi tubulaire subdivisée en une première portion tubulaire (9) et une seconde portion tubulaire (10) par ladite paroi de fond (11 ; 11 ').23. Device according to any one of claims 14 to 22, characterized in that said body (3) comprises a bottom wall (11; 11') and a tubular wall subdivided into a first tubular portion (9) and a second tubular portion (10) by said bottom wall (11; 11 ').
24. Dispositif selon la revendication 23, caractérisé en ce que ladite première portion tubulaire (9) et ladite paroi de fond (11 , 11 ') délimitent un réservoir pour contenir ladite substance liquide tandis que ladite seconde portion tubulaire (10) forme un embasement sur lequel prend appui ledit accessoire (1 ; 1 ').24. Device according to claim 23, characterized in that said first tubular portion (9) and said bottom wall (11, 11 ') define a reservoir for containing said liquid substance while said second tubular portion (10) forms a base on which said accessory (1; 1 ') is supported.
25. Dispositif selon l'une quelconque des revendications 14 à 22, caractérisé en ce que ledit corps (103 ; 203) comporte une paroi de fond (111 ; 211 ) et une paroi tronconique s'étendant d'une ouverture d'entrée (112 ; 212) jusqu'à ladite paroi de fond (111 ; 211 ). 25. Device according to any one of claims 14 to 22, characterized in that said body (103; 203) comprises a bottom wall (111; 211) and a frustoconical wall extending from an inlet opening ( 112; 212) to said bottom wall (111; 211).
26. Dispositif selon l'une quelconque des revendications 14 à 25, caractérisé en ce que ledit accessoire (1 ; 1 ') présente une nervure (13) à l'opposé dudit bec (2). 26. Device according to any one of claims 14 to 25, characterized in that said accessory (1; 1 ') has a rib (13) opposite said nozzle (2).
27. Dispositif selon l'une quelconque des revendications 14 à 26, caractérisé en ce que ledit accessoire (1 ; l') présente deux languettes (14) à l'opposé l'une de l'autre sur ledit corps (3).27. Device according to any one of claims 14 to 26, characterized in that said accessory (1; l') has two tabs (14) opposite each other on said body (3).
28. Dispositif selon la revendication 27, caractérisé en ce que ledit accessoire (1 ; l') comporte deux pattes (15) de part et d'autre de chacune desdites languettes (14).28. Device according to claim 27, characterized in that said accessory (1; l') comprises two tabs (15) on either side of each of said tongues (14).
29. Dispositif selon l'une quelconque des revendications 27 ou 28, caractérisé en ce que ledit accessoire (1 ; l') comporte deux encoches (16) bordant une ouverture d'entrée (12) au dessus desdites languettes (14). 29. Device according to any one of claims 27 or 28, characterized in that said accessory (1; l') comprises two notches (16) bordering an inlet opening (12) above said tongues (14).
30. Dispositif selon l'une quelconque des revendications 27 à 29, caractérisé en ce qu'il comporte, en outre de l'accessoire (1 ; l'), une pince (30) présentant un corps central (31) et deux bras élastiquement déformables (34) reliés audit corps central (31 ) comportant dans leur partie distale un crochet (37) apte à s'engager ou se désengager de ladite languette (14) respective dudit accessoire (1 ; 1 ') par déformation élastique desdits bras (34).30. Device according to any one of claims 27 to 29, characterized in that it comprises, in addition to the accessory (1; l'), a clamp (30) having a central body (31) and two arms elastically deformable (34) connected to said central body (31) comprising in their distal part a hook (37) capable of engaging or disengaging from said respective tongue (14) of said accessory (1; 1') by elastic deformation of said arms (34).
31. Dispositif selon la revendication 30, caractérisé en ce que lesdits bras (34) comportent un tronçon (36) disposé entre ledit corps central (31) et ledit crochet (37).31. Device according to claim 30, characterized in that said arms (34) comprise a section (36) disposed between said central body (31) and said hook (37).
32. Dispositif selon l'une quelconque des revendications 30 ou 31 , caractérisé en ce que ledit crochet (37) présente une surface convexe (38) contre laquelle vient en appui ladite languette (14) pour contraindre élastiquement lesdits bras (34).32. Device according to any one of claims 30 or 31, characterized in that said hook (37) has a convex surface (38) against which said tongue (14) bears to elastically constrain said arms (34).
33. Dispositif selon la revendication 31 , caractérisé en ce que ledit accessoire (1 ; l') comporte deux encoches (16) bordant une ouverture d'entrée (12) et en ce que chaque bras (34) présente, à la jonction entre ledit tronçon (36) et ledit crochet (37), un épaulement (42) apte à se loger dans ladite encoche respective (16) dudit accessoire (1 ; 1 ') lorsque lesdits crochets (37) sont engagés dans lesdites languettes (14).33. Device according to claim 31, characterized in that said accessory (1; l') comprises two notches (16) bordering an inlet opening (12) and in that each arm (34) has, at the junction between said section (36) and said hook (37), a shoulder (42) capable of being housed in said respective notch (16) of said accessory (1; 1') when said hooks (37) are engaged in said tongues (14) .
34. Dispositif selon l'une quelconque des revendications 14 à 33, caractérisé en ce qu'il comporte, en outre de l'accessoire (1 ; l'), un porte- accessoire (60) comportant un socle (61 ) sur lequel prend appui ledit accessoire (1 ; l') lorsqu'il repose sur ledit porte-accessoire (60) et des pattes (62) contre lesquelles ledit accessoire (1 ; 1 ') vient en butée lorsque ledit accessoire (1 ; l') est dans une position de butée, ledit bec (2 ; 102 ; 202) saillant au delà desdites pattes (62).34. Device according to any one of claims 14 to 33, characterized in that it comprises, in addition to the accessory (1; l'), an accessory holder (60) comprising a base (61) on which supports said accessory (1; l') when it rests on said accessory holder (60) and legs (62) against which said accessory (1; 1 ') abuts when said accessory (1; l') is in a stop position, said nozzle (2; 102; 202) projecting beyond said legs (62).
35. Dispositif selon la revendication 34, caractérisé en ce que lesdites pattes (62) présentent un renfoncement en arc de cercle (67) contre lequel vient en butée ledit accessoire dans ladite position de butée (1 ; 1 ').35. Device according to claim 34, characterized in that said tabs (62) have an arcuate recess (67) against which said accessory abuts in said abutment position (1; 1 ').
36. Dispositif selon l'une quelconque des revendications 34 ou 35, caractérisé en ce que lesdites pattes (62) sont séparées par une rainure à profil tronconique (66) dans lequel se loge ledit accessoire (1 ; l').36. Device according to any one of claims 34 or 35, characterized in that said legs (62) are separated by a groove with a frustoconical profile (66) in which said accessory (1; l') is housed.
37. Dispositif selon la revendication 36, caractérisé en ce que ledit accessoire (1 ; l') présente deux languettes (14). à l'opposé l'une de l'autre sur ledit corps (3) et deux pattes (15) de part et d'autre de chacune desdites languettes (14) et en ce que lesdites pattes (62) dudit porte-accessoire (60) présentent du coté opposé à ladite rainure tronconique (66) un rebord (68) saillant sous lequel se loge une dite patte (15) dudit accessoire (1 ; l') lorsque ledit accessoire (1 ; l') est dans ladite position de butée.37. Device according to claim 36, characterized in that said accessory (1; l') has two tabs (14). opposite each other on said body (3) and two tabs (15) on either side of each of said tabs (14) and in that said tabs (62) of said accessory holder ( 60) have on the side opposite said frustoconical groove (66) a projecting rim (68) under which a said tab (15) of said accessory (1; l') is housed when said accessory (1; l') is in said position of stop.
38. Dispositif selon l'une quelconque des revendications 14 à 37, caractérisé en ce qu'il comporte, en outre de l'accessoire, un poussoir (50) comportant un presseur (53) et un vérin comportant une tige (51) et un corps (52), ledit presseur (53) étant apte à venir en appui contre ledit accessoire (1 ; l') pour que l'accessoire glisse d'une première position à une seconde position.38. Device according to any one of claims 14 to 37, characterized in that it comprises, in addition to the accessory, a pusher (50) comprising a presser (53) and a cylinder comprising a rod (51) and a body (52), said presser (53) being able to come to bear against said accessory (1; l') so that the accessory slides from a first position to a second position.
39. Dispositif selon la revendication 38, caractérisé en ce que ledit presseur présente un renfoncement en arc de cercle (54) pour venir au contact dudit accessoire (1 ; 1 ').39. Device according to claim 38, characterized in that said presser has an arcuate recess (54) to come into contact with said accessory (1; 1 ').
40. Dispositif selon l'une quelconque des revendications 38 ou 39, caractérisé en ce ledit accessoire (1 ; l') présente une nervure (13) à l'opposé dudit bec (2) et en ce que ledit presseur (53) et ladite nervure (13) présentent un agencement apte à ce que ladite nervure (13) se loge sous la surface inférieure (55) dudit presseur (53) lorsque ledit presseur (53) vient au contact dudit accessoire (1 ; l'). 40. Device according to any one of claims 38 or 39, characterized in that said accessory (1; l') has a rib (13) opposite said nozzle (2) and in that said presser (53) and said rib (13) have an arrangement capable of said rib (13) being housed under the lower surface (55) of said presser (53) when said presser (53) comes into contact with said accessory (1; l').
41. Dispositif selon l'une quelconque des revendications 14 à 40 convenant à la mise en œuvre du procédé selon l'une quelconque des revendications 1 à 13, comportant un accessoire (1 ; l' ; 101 ; 201) adapté à être emboîté dans une paillette (25) en position couchée pour y introduire une dose prédéterminée (26') de substance liquide initialement contenue dans un réceptacle (45) ouvert sur le dessus, caractérisé en ce que ledit accessoire présente un bec (2 ; 102 ; 202) à canal capillaire (4 ; 104 ; 204) formé d'un seul bloc rigide adapté à être emboîté dans ladite paillette (25). 41. Device according to any one of claims 14 to 40 suitable for implementing the method according to any one of claims 1 to 13, comprising an accessory (1; l';101; 201) adapted to be fitted into a straw (25) in the lying position to introduce a dose predetermined amount (26') of liquid substance initially contained in a receptacle (45) open on the top, characterized in that said accessory has a spout (2; 102; 202) with capillary channel (4; 104; 204) formed of a single rigid block adapted to be fitted into said straw (25).
42. Dispositif selon la revendication 41 , caractérisé en ce que ledit bec (2) comporte une portion tronconique (7') et une portion cylindrique (8').42. Device according to claim 41, characterized in that said nozzle (2) comprises a frustoconical portion (7') and a cylindrical portion (8').
43. Dispositif selon l'une quelconque des revendications 41 ou 42, caractérisé en ce que ledit bec (2) comporte un canal capillaire (4).43. Device according to any one of claims 41 or 42, characterized in that said nozzle (2) comprises a capillary channel (4).
44. Dispositif selon l'une quelconque des revendications 41 à 43, caractérisé en ce que ledit bec (2) est moulé d'une seule pièce en matière plastique rigide. 44. Device according to any one of claims 41 to 43, characterized in that said nozzle (2) is molded in one piece from rigid plastic material.
EP06764781.8A 2005-06-14 2006-06-13 Method for packing a predetermined liquid substance dose in a straw and device for carrying out said method Not-in-force EP1893123B1 (en)

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FR0506014A FR2886931B1 (en) 2005-06-14 2005-06-14 PROCESS FOR CONDITIONING A PREDETERMINED DOSE OF LIQUID SUBSTANCE IN A STRAIN AND DEVICE FOR IMPLEMENTING THE SAME
PCT/FR2006/001332 WO2006134265A1 (en) 2005-06-14 2006-06-13 Method for packing a predetermined liquid substance dose in a straw and device for carrying out said method

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Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2414383T5 (en) * 2010-01-15 2016-12-12 Graphic Packaging International, Inc. Continuous chain claw for octagonal cardboard boxes
US10531657B2 (en) 2015-12-07 2020-01-14 Coopersurgical, Inc. Low temperature specimen carriers and related methods
US20170297013A1 (en) * 2016-04-14 2017-10-19 Jesse Cohen Universal Transfer Pipette
RU175564U1 (en) * 2016-12-29 2017-12-11 Общество с ограниченной ответственностью "Фармпласт" Catheter fluid filling device for artificial insemination of birds and pets
RU177752U1 (en) * 2016-12-29 2018-03-12 Общество с ограниченной ответственностью "Фармпласт" Artificial insemination catheter for birds and pets
CN114348321B (en) * 2022-01-26 2023-08-04 江苏集萃药康生物科技股份有限公司 Automatic tubing equipment for animal genetic material

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2994349A (en) * 1957-10-29 1961-08-01 Peter T Demos Pipette control device
US3233785A (en) * 1962-09-13 1966-02-08 Dade Reagents Inc Rinsing pipette
US3834463A (en) * 1973-02-28 1974-09-10 Itt Sensitive sprinkler
FR2520631A1 (en) 1982-02-01 1983-08-05 Gozal David PROCESS FOR FLOCULATING SUSPENDED MICROSCOPIC PARTICLES IN A LIQUID AND APPLICATION TO THE COLLECTION OF PHYTOPLANCTONIC MICROALOGUES AND ZOOPLANKTON IN SUSPENSION IN WATER
US4618002A (en) * 1984-03-13 1986-10-21 Grinnel Corporation Fire protection sprinkler head
DE3868782D1 (en) * 1987-07-22 1992-04-09 Robert Cassou TUBES FOR STORING SMALL QUANTITIES, ESPECIALLY OF BIOLOGICAL SUBSTANCES, AND THE USE THEREOF IN A FERTILIZATION METHOD.
US4779768A (en) * 1987-07-24 1988-10-25 St. Amand Manufacturing Co., Inc. Volumetric dispensing pipette
IE62637B1 (en) * 1988-09-22 1995-02-22 Eolas Irish Science & Tech Apparatus for filling tubes
US4939884A (en) * 1989-04-14 1990-07-10 Glenn Peters Honey stick machine
FR2651793B1 (en) 1989-09-14 1991-12-06 Cassou Robert TUBES OR SEQUINS FOR THE CRYOGENIC PRESERVATION OF BIOLOGICAL SAMPLES SUCH AS VIRUSES, AND FILLING METHOD.
GB9208386D0 (en) * 1992-04-16 1992-06-03 Amersham Int Plc Storage and dispensing device for liquids
US5402915A (en) * 1993-11-30 1995-04-04 Kaneka Texas Corporation Bottom draining bin-type, bulk fluid container with insert
US5673823A (en) * 1995-08-21 1997-10-07 Blue Cow, Inc. Compact bottom feed container
FR2753367B1 (en) * 1996-09-19 1998-12-04 Lecointe Pascal STORAGE STRAW OF A LIQUID BIOLOGICAL SUBSTANCE AND FILLING METHOD THEREOF
FR2758973B1 (en) 1997-01-31 1999-06-11 Instr Medecine Veterinaire FILLING TIP FOR BIOLOGICAL LIQUID PACKAGING ELEMENTS, IN PARTICULAR FOR ARTIFICIAL INSEMINATION
US6126632A (en) * 1999-03-24 2000-10-03 Verbovszky; Esther Gravity cup with adjustable, interchangeable and disposable tube straw valve
FR2810535B1 (en) * 2000-06-27 2002-10-11 Eurl Cryo Vet METHOD FOR FILLING A STORAGE FLAP WITH SEED
US7479391B2 (en) * 2004-12-10 2009-01-20 Tecan Trading Ag Pipetting apparatus with integrated liquid level and/or gas bubble detection

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2006134265A1 *

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KR20080023321A (en) 2008-03-13
FR2886931A1 (en) 2006-12-15
CN101198292B (en) 2010-09-01
KR101014212B1 (en) 2011-02-14
RU2369357C1 (en) 2009-10-10
RU2008101412A (en) 2009-07-20
EP1893123B1 (en) 2017-08-09
WO2006134265A1 (en) 2006-12-21
FR2886931B1 (en) 2007-08-17
US20080202628A1 (en) 2008-08-28
US9211171B2 (en) 2015-12-15
CN101198292A (en) 2008-06-11

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