EP1892728B1 - Process of producing the radioisotope TL-201 - Google Patents
Process of producing the radioisotope TL-201 Download PDFInfo
- Publication number
- EP1892728B1 EP1892728B1 EP06119491.6A EP06119491A EP1892728B1 EP 1892728 B1 EP1892728 B1 EP 1892728B1 EP 06119491 A EP06119491 A EP 06119491A EP 1892728 B1 EP1892728 B1 EP 1892728B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- liquid
- target material
- ion exchange
- processing
- radioisotope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
- G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
- G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0078—Thallium
Definitions
- the present invention relates to producing T1-201; more particularly, it relates to quickly filtering out a high-purity T1-201 liquid.
- T1-201 thallous chloride ( 201 T1Cl 2 ) can be absorbed by heart muscle to be gathered at the heart muscle. Therefore, T1-201 can be used in a myocardial image for diagnosing heart disease; and can be applied in other medical diagnoses, like a tumor image. Hence, T1-201 is the most commonly used radioisotope in division of nuclear medicine.
- T1-201 is directly washed out. But the T1-201 directly washed out quite often contains impurities so that its purity is not good. Hence, the prior art does not fulfill users' requests on actual use.
- US 3,993,538 discloses a process of producing T1-201 having a purity of at least 99%.
- the nuclear reaction is T1-203 (p,3n) Pb-201.
- the thallium target is fabricated from an ingot of 99.999% pure thallium metal. After irradiation, the thallium target is dissolved in concentrated nitric acid, then evaporated to dryness. This salt is then dissolved in complexing agent EDTA and passed through a Bio-Rad Dowex resin column. Most of the thallium target material adheres to the column and the eluate contains radioactive Pb-203 and Pb-201.
- the eluate is acidified by adding an equal volume of concentrated HNO 3 and the thallium then oxidized by the addition of Clorox.
- Pb(NO 3 ) 2 carrier is added to the eluate and the solution is passed through a Bio-Rad Dowex resin column. Thallium adheres to this column and the lead activities are eluted.
- the eluate containing Pb-203 and Pb-201 is allowed to stand overnight to permit the Pb-201 to decay into T1-201. It is then passed through another Bio-Rad Dowex column, to which the T1-201 +3 adheres and through which the lead activities are eluted.
- T1-201 activity is then eluted with hot hydrazine-sulfate solution, reducing T1-201 +3 to T1-201 +3 .
- This T1-201 +1 eluate is evaporated to dryness twice with concentrated HNO 3 and once with concentrated HCl.
- the product is then dissolved in NaOH and the pH adjusted to 7 by further addition of NaOH.
- the product is sterilized by filtration into a sterile multi-injection bottle through a 0.22 micron sterilized millipore filter.
- US 4,297,166 A1 discloses a method of producing a T1-203 target through electroplating.
- the object of the present invention is to provide an alternative method for producing high-purity T1-201 liquid.
- the present invention is a radioisotope T1-201 production process, where a T1-203 solid target material is obtained from a plated target material of T1-203 through electroplating; the T1-203 solid target material is irradiated with a proton beam by using a cyclotron; the T1-203 solid target material is dissolved with a strong acid liquid to obtain a Pb-201 solution and a T1-203 solution; ammonia and water are added for a precipitation to separate a T1-203 liquid and a Pb-201 liquid out; hydrochloric acid is added for a first ion exchange with a resin while impurities are filtered out; the Pb-201 liquid is taken out to be decayed into a T1-201 liquid; and a hydrochloric acid (HC1) having sulfur dioxide (SO 2 ) is added to the T1-201 liquid to obtain a T1-201 liquid having a high purity through a second ion exchange by using a resin.
- HC1 hydrochloric acid having sulfur dioxide (SO
- FIG.1 is a plot view showing a process flow of a preferred embodiment according to the present invention.
- the present invention is a radioisotope T1-201 production process, comprising electroplating 1, irradiating 2, processing a first chemical separation 3, decaying 4 and processing a second chemical separation 5, where the first chemical separation 3 comprises dissolving 31, processing a precipitation 32 and processing a first ion exchange 33; and the second chemical separation 5 is a second ion exchange.
- a novel radioisotope T1-201 production process is obtained for acquiring a T1-201 liquid having a high purity.
- FIG.2 is a detailed view showing a flow chart of the preferred embodiment. As shown in the figure, when producing a radioisotope T1-201 according to the present invention, the following steps are processed:
- the present invention is a radioisotope T1-201 production process, where a T1-203 solid target material is formed through an electroplating; the T1-203 solid target material is irradiated with a proton beam; the T1-203 solid target material is dissolved to be processed through a first chemical separation and a second chemical separation; and a T1-201 liquid is quickly filtered out, which has a high purity.
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Manufacture And Refinement Of Metals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Nuclear Medicine (AREA)
Description
- The present invention relates to producing T1-201; more particularly, it relates to quickly filtering out a high-purity T1-201 liquid.
- T1-201 thallous chloride (201T1Cl2) can be absorbed by heart muscle to be gathered at the heart muscle. Therefore, T1-201 can be used in a myocardial image for diagnosing heart disease; and can be applied in other medical diagnoses, like a tumor image. Hence, T1-201 is the most commonly used radioisotope in division of nuclear medicine.
- To produce a T1-201, as revealed in "Production of T1-201 and Pb203 via Proton Induced Nuclear Reaction on Natural Thallium," by Qaim S. M., Weinreich R. and Ollig H., International Journal of Applied Radiation and Isotopes, 30 (1979) pp.85-95, T1-201 is directly washed out. But the T1-201 directly washed out quite often contains impurities so that its purity is not good. Hence, the prior art does not fulfill users' requests on actual use.
- Further,
US 3,993,538 discloses a process of producing T1-201 having a purity of at least 99%. The nuclear reaction is T1-203 (p,3n) Pb-201. The thallium target is fabricated from an ingot of 99.999% pure thallium metal. After irradiation, the thallium target is dissolved in concentrated nitric acid, then evaporated to dryness. This salt is then dissolved in complexing agent EDTA and passed through a Bio-Rad Dowex resin column. Most of the thallium target material adheres to the column and the eluate contains radioactive Pb-203 and Pb-201. The eluate is acidified by adding an equal volume of concentrated HNO3 and the thallium then oxidized by the addition of Clorox. Pb(NO3)2 carrier is added to the eluate and the solution is passed through a Bio-Rad Dowex resin column. Thallium adheres to this column and the lead activities are eluted. The eluate containing Pb-203 and Pb-201 is allowed to stand overnight to permit the Pb-201 to decay into T1-201. It is then passed through another Bio-Rad Dowex column, to which the T1-201+3 adheres and through which the lead activities are eluted. The T1-201 activity is then eluted with hot hydrazine-sulfate solution, reducing T1-201+3 to T1-201+3. This T1-201+1 eluate is evaporated to dryness twice with concentrated HNO3 and once with concentrated HCl. The product is then dissolved in NaOH and the pH adjusted to 7 by further addition of NaOH. The product is sterilized by filtration into a sterile multi-injection bottle through a 0.22 micron sterilized millipore filter. -
US 4,297,166 A1 discloses a method of producing a T1-203 target through electroplating. - The object of the present invention is to provide an alternative method for producing high-purity T1-201 liquid.
- This object is achieved by a process according to
claim 1. - To achieve the above purpose, the present invention is a radioisotope T1-201 production process, where a T1-203 solid target material is obtained from a plated target material of T1-203 through electroplating; the T1-203 solid target material is irradiated with a proton beam by using a cyclotron; the T1-203 solid target material is dissolved with a strong acid liquid to obtain a Pb-201 solution and a T1-203 solution; ammonia and water are added for a precipitation to separate a T1-203 liquid and a Pb-201 liquid out; hydrochloric acid is added for a first ion exchange with a resin while impurities are filtered out; the Pb-201 liquid is taken out to be decayed into a T1-201 liquid; and a hydrochloric acid (HC1) having sulfur dioxide (SO2) is added to the T1-201 liquid to obtain a T1-201 liquid having a high purity through a second ion exchange by using a resin. Accordingly, a novel radioisotope T1-201 production process is obtained.
- The present invention will be better understood from the following detailed description of the preferred embodiment according to the present invention, taken in conjunction with the accompanying drawings, in which
- FIG.1
- is the plot view showing the process flow of the preferred embodiment according to the present invention; and
- FIG.2
- is the detailed view showing the flow chart of the preferred embodiment.
- The following description of the preferred embodiment is provided to understand the features and the structures of the present invention.
-
FIG.1 is a plot view showing a process flow of a preferred embodiment according to the present invention. As shown in the figure, the present invention is a radioisotope T1-201 production process, comprising electroplating 1, irradiating 2, processing a firstchemical separation 3, decaying 4 and processing a second chemical separation 5, where the firstchemical separation 3 comprises dissolving 31, processing aprecipitation 32 and processing afirst ion exchange 33; and the second chemical separation 5 is a second ion exchange. Thus, a novel radioisotope T1-201 production process is obtained for acquiring a T1-201 liquid having a high purity. -
FIG.2 is a detailed view showing a flow chart of the preferred embodiment. As shown in the figure, when producing a radioisotope T1-201 according to the present invention, the following steps are processed: - (a) Electroplating 1: A T1-203
solid target material 12 is obtained from aplated target material 11 of T1-203 through electroplating. - (b) Irradiating 2: The T1-203
solid target material 12 is irradiated with a proton beam by using acyclotron 21, where an irradiation energy of thecyclotron 21 is located between fifteen mega electron volts (MeV) and forty MeV. - (c) Processing a first chemical separation: The first
chemical separation 3 comprises the following steps:- (c1) Dissolving 31: After the irradiating, the T1-203
solid target material 12 is dissolved with astrong acid liquid 34 to obtain a Pb-201solution 35 and a Tl-203solution 36, where thestrong acid liquid 34 is a solution of nitric acid having ferric iron (HNO3/Fe3/H2O). - (c2) Processing a precipitation 32: Ammonia (NH3) and
water 321 are added to the Pb-201solution 35 and the Tl-203solution 36 for a precipitation to separate out a T1-203liquid 37 and a Pb-201liquid 38; and - (c3) Processing a first ion exchange 33: Hydrochloric acid (HCl) 331 is added to the T1-203
liquid 37 and the Pb-201liquid 38 for a first ion exchange by using aresin 332 with impurities filtered out;
- (c1) Dissolving 31: After the irradiating, the T1-203
- (d) Decaying 4: The Pb-201 liquid is taken out to be decayed into a T1-201
liquid 41. - (e) Processing a second chemical separation: And a second chemical separation 5 is processed, which is a
second ion exchange 51.- (e1) Processing a second ion exchange 51: An HCl acid having sulfur dioxide (SO2) 511 is added to the T1-201
liquid 41 to obtain a T1-201liquid 52 having a high purity through a second ion exchange by using aresin 512.
- (e1) Processing a second ion exchange 51: An HCl acid having sulfur dioxide (SO2) 511 is added to the T1-201
- Thus, a novel radioisotope T1-201 production process is obtained.
- To sum up, the present invention is a radioisotope T1-201 production process, where a T1-203 solid target material is formed through an electroplating; the T1-203 solid target material is irradiated with a proton beam; the T1-203 solid target material is dissolved to be processed through a first chemical separation and a second chemical separation; and a T1-201 liquid is quickly filtered out, which has a high purity.
Claims (1)
- Process of producing the radioisotope Tl-201, comprising steps of:(a) Electroplating (1): wherein a T1-203 solid target material is obtained from a plated target material of Tl-203 through electroplating;(b) Irradiation (2): wherein said T1-203 solid target material is irradiated with a proton beam by using a cyclotron, wherein the irradiation energy of said cyclotron is located between 15MeV and 40 MeV;(c) Processing a first chemical separation (3) comprising the following steps:(c1) Dissolving: wherein, after said irradiation, said T1-203 solid target material is dissolved with a strong acid liquid to obtain a Pb-201 and T1-203 solution, wherein said strong acid liquid is HNO3/Fe3/H2O;(c2) Processing a precipitation: wherein NH3 and water are applied to said Pb-201 and T1-203 solution for a precipitation to obtain a T1-203 liquid and a Pb-201 liquid;(c3) Processing a first ion exchange: wherein HCl is applied to said Tl-203 liquid and said Pb-201 liquid for an ion exchange by using a resin with impurities filtered out;(d) Decaying (4): wherein said Pb-201 liquid is obtained to be decayed into a Tl-201 liquid; and(e) Processing a second chemical separation (5) comprising the following step:(e1) Processes a second ion exchange: wherein an HCl having SO2 is applied to said T1-201 liquid to obtain a T1-201 liquid having a high purity through an second ion exchange by using a resin.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20060119491 EP1892728B9 (en) | 2006-08-24 | 2006-08-24 | Process of producing the radioisotope Tl-201 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20060119491 EP1892728B9 (en) | 2006-08-24 | 2006-08-24 | Process of producing the radioisotope Tl-201 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1892728A1 EP1892728A1 (en) | 2008-02-27 |
EP1892728B1 true EP1892728B1 (en) | 2013-12-04 |
EP1892728B9 EP1892728B9 (en) | 2014-04-09 |
Family
ID=37607072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20060119491 Not-in-force EP1892728B9 (en) | 2006-08-24 | 2006-08-24 | Process of producing the radioisotope Tl-201 |
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EP (1) | EP1892728B9 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1916669B1 (en) * | 2006-10-25 | 2014-12-24 | Atomic Energy Council - Institute of Nuclear Energy Research | Separation Device for Radioisotope Tl-201 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3993538A (en) | 1976-01-27 | 1976-11-23 | The United States Of America As Represented By The United States Energy Research And Development Administration | Production of high purity radiothallium |
JPS54111100A (en) | 1978-02-20 | 1979-08-31 | Nihon Mediphysics Co Ltd | Method of making thallium target for irradiation in cyclotron |
-
2006
- 2006-08-24 EP EP20060119491 patent/EP1892728B9/en not_active Not-in-force
Also Published As
Publication number | Publication date |
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EP1892728A1 (en) | 2008-02-27 |
EP1892728B9 (en) | 2014-04-09 |
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