EP1876893A4 - Procede pour traiter un cancer grace a l'inhibition combinee d'activites de proteasome et de telomerase - Google Patents

Procede pour traiter un cancer grace a l'inhibition combinee d'activites de proteasome et de telomerase

Info

Publication number
EP1876893A4
EP1876893A4 EP06750227A EP06750227A EP1876893A4 EP 1876893 A4 EP1876893 A4 EP 1876893A4 EP 06750227 A EP06750227 A EP 06750227A EP 06750227 A EP06750227 A EP 06750227A EP 1876893 A4 EP1876893 A4 EP 1876893A4
Authority
EP
European Patent Office
Prior art keywords
proteasome
cancer treatment
combined inhibition
telomerase
telomerase activities
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP06750227A
Other languages
German (de)
English (en)
Other versions
EP1876893A2 (fr
EP1876893B1 (fr
Inventor
Malcolm A S Moore
Allison C Chin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geron Corp
Memorial Sloan Kettering Cancer Center
Original Assignee
Sloan Kettering Institute for Cancer Research
Geron Corp
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Institute for Cancer Research, Geron Corp, Memorial Sloan Kettering Cancer Center filed Critical Sloan Kettering Institute for Cancer Research
Publication of EP1876893A2 publication Critical patent/EP1876893A2/fr
Publication of EP1876893A4 publication Critical patent/EP1876893A4/fr
Application granted granted Critical
Publication of EP1876893B1 publication Critical patent/EP1876893B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/314—Phosphoramidates
    • C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
EP06750227A 2005-04-15 2006-04-14 Procede pour traiter un cancer grace a l'inhibition combinee d'activites de proteasome et de telomerase Active EP1876893B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67163005P 2005-04-15 2005-04-15
PCT/US2006/014137 WO2006113470A2 (fr) 2005-04-15 2006-04-14 Procede pour traiter un cancer grace a l'inhibition combinee d'activites de proteasome et de telomerase

Publications (3)

Publication Number Publication Date
EP1876893A2 EP1876893A2 (fr) 2008-01-16
EP1876893A4 true EP1876893A4 (fr) 2010-09-01
EP1876893B1 EP1876893B1 (fr) 2012-04-11

Family

ID=37115747

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06750227A Active EP1876893B1 (fr) 2005-04-15 2006-04-14 Procede pour traiter un cancer grace a l'inhibition combinee d'activites de proteasome et de telomerase

Country Status (4)

Country Link
US (1) US7998938B2 (fr)
EP (1) EP1876893B1 (fr)
AT (1) ATE553198T1 (fr)
WO (1) WO2006113470A2 (fr)

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AU2004271215B2 (en) 2003-09-09 2009-07-16 Geron Corporation Modified oligonucleotides for telomerase inhibition
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CA2613889A1 (fr) 2005-06-08 2006-12-14 Centocor, Inc. Therapie cellulaire pour la degenerescence oculaire
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WO2007127163A2 (fr) * 2006-04-24 2007-11-08 Geron Corporation Méthode et composition pour le traitement d'une tumeur du snc
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
DK2041158T3 (da) 2006-06-19 2013-06-24 Onyx Therapeutics Inc Peptid-epoxidketoner til proteasom inhibering
ES2696828T3 (es) 2006-10-30 2019-01-18 Geron Corp Inhibidor de telomerasa y gemcitabina combinados para el tratamiento del cáncer
EP2134364B1 (fr) * 2007-03-09 2013-02-13 Geron Corporation Traitement de carcinomes avec une combinaison d'inhibiteurs de voie egf et de telomerase
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
KR101617243B1 (ko) 2007-07-31 2016-05-02 라이프스캔, 인코포레이티드 인간 배아 줄기 세포의 분화
KR20170125413A (ko) 2007-10-04 2017-11-14 오닉스 세라퓨틱스, 인크. 결정형 펩티드 에폭시 케톤 프로테아제 저해제 및 아미노산 케토-에폭시드의 합성
US8377992B2 (en) 2007-10-22 2013-02-19 The Wistar Institute TRBD-binding effectors and methods for using the same to modulate telomerase activity
KR101592182B1 (ko) 2007-11-27 2016-02-05 라이프스캔, 인코포레이티드 인간 배아 줄기 세포의 분화
KR101731474B1 (ko) 2008-02-21 2017-05-11 얀센 바이오테크 인코포레이티드 세포 부착, 배양 및 탈리를 위한 방법, 표면 개질 플레이트 및 조성물
PL2942392T3 (pl) 2008-06-30 2019-02-28 Janssen Biotech, Inc Różnicowanie pluripotencjalnych komórek macierzystych
WO2010048298A1 (fr) 2008-10-21 2010-04-29 Proteolix, Inc. Thérapie de combinaison avec des peptides époxycétones
US9234178B2 (en) 2008-10-31 2016-01-12 Janssen Biotech, Inc. Differentiation of human pluripotent stem cells
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JP5719305B2 (ja) 2008-11-20 2015-05-13 ヤンセン バイオテツク，インコーポレーテツド 平面支持体上での細胞付着及び培養のための方法及び組成物
US9689028B2 (en) 2008-12-22 2017-06-27 University Of Utah Foundation Monochrome multiplex quantitative PCR
AR075899A1 (es) 2009-03-20 2011-05-04 Onyx Therapeutics Inc Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
MX340952B (es) 2009-07-20 2016-07-29 Janssen Biotech Inc Diferenciacion de celulas madre embrionarias humanas.
RU2540016C2 (ru) 2009-07-20 2015-01-27 Янссен Байотек, Инк. Дифференцировка эмбриональных стволовых клеток человека
WO2011011300A2 (fr) 2009-07-20 2011-01-27 Centocor Ortho Biotech Inc. Différentiation de cellules souches embryonnaires humaines
EP2519231B1 (fr) 2009-10-01 2017-03-15 Janssen Pharmaceutica NV Traitement du cancer par des inhibiteurs du protéasome
US8853147B2 (en) 2009-11-13 2014-10-07 Onyx Therapeutics, Inc. Use of peptide epoxyketones for metastasis suppression
US9150833B2 (en) 2009-12-23 2015-10-06 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
SG181685A1 (en) 2009-12-23 2012-07-30 Centocor Ortho Biotech Inc Differentiation of human embryonic stem cells
RU2607380C2 (ru) 2010-03-01 2017-01-10 Янссен Байотек, Инк. Способы очистки клеток, производных от плюрипотентных стволовых клеток
US9359398B2 (en) 2010-03-01 2016-06-07 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
WO2011143299A2 (fr) 2010-05-12 2011-11-17 Centocor Ortho Biotech Inc. Différentiation de cellules souches embryonnaires humaines
US9506036B2 (en) 2010-08-31 2016-11-29 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
MX348537B (es) 2010-08-31 2017-06-07 Janssen Biotech Inc Diferencia de celulas madre pluripotentes.
EP3211070A1 (fr) 2010-08-31 2017-08-30 Janssen Biotech, Inc. Différenciation de cellules souches embryonnaires humaines
RU2705001C2 (ru) 2011-12-22 2019-11-01 Янссен Байотек, Инк. Дифференцировка эмбриональных стволовых клеток человека в одногормональные инсулинположительные клетки
CN104160018A (zh) 2012-03-07 2014-11-19 詹森生物科技公司 用于扩增和维持多能干细胞的成分确定的培养基
ES2690118T3 (es) 2012-06-08 2018-11-19 Janssen Biotech, Inc. Diferenciación de células madre embrionarias humanas en células endocrinas pancreáticas
WO2014011695A2 (fr) 2012-07-09 2014-01-16 Onyx Therapeutics, Inc. Promédicaments d'inhibiteurs d'époxy cétone protéase peptidique
US9200327B2 (en) 2012-11-30 2015-12-01 Geron Corporation Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors
CA2892445C (fr) * 2012-11-30 2022-06-28 Geron Corporation Marqueurs de diagnostic pour le traitement de troubles de la proliferation cellulaire par des inhibiteurs de telomerase
US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
DK3456333T3 (da) 2012-12-07 2020-05-18 Geron Corp Anvendelse af telomeraseinhibitor imetelstat til behandling af myelodysplastisk syndrom
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KR101942769B1 (ko) 2012-12-31 2019-01-28 얀센 바이오테크 인코포레이티드 Hb9 조절제를 사용하는 인간 배아 줄기세포의 췌장 내분비 세포로의 분화
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WO2017165675A1 (fr) * 2016-03-24 2017-09-28 The Board Of Regents Of The University Of Texas System Traitement de maladies prolifératives résistantes aux médicaments au moyen de composés modifiant les télomères induits par la télomérase
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Also Published As

Publication number Publication date
US20100010064A1 (en) 2010-01-14
WO2006113470A2 (fr) 2006-10-26
EP1876893A2 (fr) 2008-01-16
US7998938B2 (en) 2011-08-16
EP1876893B1 (fr) 2012-04-11
WO2006113470A3 (fr) 2006-12-14
ATE553198T1 (de) 2012-04-15

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