EP1852187B1 - Système de stockage d'échantillons pour le développement pharmaceutique - Google Patents

Système de stockage d'échantillons pour le développement pharmaceutique Download PDF

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Publication number
EP1852187B1
EP1852187B1 EP07003806A EP07003806A EP1852187B1 EP 1852187 B1 EP1852187 B1 EP 1852187B1 EP 07003806 A EP07003806 A EP 07003806A EP 07003806 A EP07003806 A EP 07003806A EP 1852187 B1 EP1852187 B1 EP 1852187B1
Authority
EP
European Patent Office
Prior art keywords
tubes
partition walls
walls
tube
grid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP07003806A
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German (de)
English (en)
Other versions
EP1852187A1 (fr
Inventor
Hiroyuki c/o Tsubakimoto Chain Co. Taike
Kazuhiro c/o Tsubakimoto Chain Co. Tsutsumi
Hisao c/o Tsubakimoto Chain Co. Nishii
Nobuaki c/o Tsubakimoto Chain Co. Matsumoto
Yukio c/p Tsubakimoto Chain Co. Ueyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tsubakimoto Chain Co
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Tsubakimoto Chain Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of EP1852187A1 publication Critical patent/EP1852187A1/fr
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Publication of EP1852187B1 publication Critical patent/EP1852187B1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50855—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using modular assemblies of strips or of individual wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/06—Test-tube stands; Test-tube holders

Definitions

  • the present invention relates to a samples storage system for pharmaceutical development used for identifying and storing a number of samples in a field of a pharmaceutical development research or the like, and more specifically it relates to a samples storage system for pharmaceutical development including tubes for sealing samples for pharmaceutical development and a storage rack for vertically accommodating 384 tubes in a grid pattern.
  • the storage and transportation of samples has been carried out by sealing or encapsulating a sample-dissolved solution into a tube case so called as a microtube and accommodating a plurality of microtubes in a vertically provided manner in a storage rack which is partitioned in a grid patten, for example partitioned into 96 receptacles in a matrix with 8 rows and 12 columns.
  • FIG. 8 shows a samples storage system 800 for pharmaceutical development for accommodating ultramicrotubes (or 384 tubes) described in European Patent Application Publication No. 0904841 .
  • this samples storage system 800 for pharmaceutical development in a storage rack 810 with the same size as the storage rack in accordance with an SBS standard, in which 96 tubes are accommodated, it is four times number of tubes, that is 384, tubular ultramicrotubes 820 with bottoms are accommodated.
  • the above-mentioned ultramicrotubes 820 take a shape in which a bottom surface size of a the ultramicrotubes (384 tubes) was reduced to substantially 1/4 of the surface size of the microtubes (96 tubes), the capacity of samples to be accommodated must be decreased.
  • engagement partition walls 816 for forming accommodation sections 813 partitioned in a matrix with 16 rows and 24 columns are formed at substantially the same height as a rack frame 814 of the storage rack 810, an accommodation region in the ultramicrotubes 820 is decreased by the thickness of these engagement partition walls 816 and the capacity of samples to be accommodated was even more restricted as compared with the mcirotubes (96 tubes).
  • FIG. 9 shows a partial cross-sectional view of a samples storage system 900 for pharmaceutical development accommodating ultramicrotubes described in European Patent Application Publication No.1477226 .
  • a storage rack 910 accommodates four times number of tubes, that is ultramicrotubes 920, is the same size storage rack 910 as a storage rack in accordance with the SBS standard, accommodating microtubes (96 tubes) like the conventional case shown in FIG. 8 . Since the ultramicrotubes 920 in this storage rack 910 have a rectangular hollow tubluar cross-section, the storage rack 910 has a greater accommodation volume than the tubular ultramicrotubes shown in FIG. 8 .
  • EP 1 745 850 A2 is showing another sample storage system for pharmaceutical development.
  • the object of the present invention is to provide a samples storage system for pharmaceutical development in which the accommodation volumes of ultramicrotubes are increased and smooth insertion and extraction of ultramicrotubes become possible irrespective of the accommodation positions of the ultramicrotubes relative to the side walls.
  • a samples storage system for pharmaceutical development including tubes in which samples for pharmaceutical development are sealed and a storage rack with receptacles for vertically accommodating a plurality of the tubes in a grid pattern, characterized in that the tube is of a rectangular hollow tubluar cross-section and is tapered toward the bottom portion of the tube and at the same time corner portions of the outer four side surfaces of the tubes are o chamfered, the storage rack has engagement partition walls forming grid pattern receptacles inside the rack frame. The height of the walls is smaller than the length of the tube.
  • the grid partition walls have tube-supporting pins vertically extending from their respective intersections of the grid.
  • the tubes accommodated adjacent the outermost sides are held vertical by the partition walls which are spaced from the frame and the tube-supporting pins projecting upwardly from the intersections of the grid in the same manner as the tubes in the middle of the rack.
  • the material of the tube and the rack used in the present invention is not limited particularly, but polypropylene (PP) or polycarbonate (PC) is preferably used as the material.
  • the tube is of a rectangular hollow tubluar cross-section and is tapered toward the bottom portion of the tube and at the same time corner portions of the outer four side surfaces of the tubes are chamfered.
  • the storage rack has engagement partition walls forming grid pattern receptacles inside the rack frame. The height of the walls is smaller than the length of the tube, and the grid partition walls have tube-supporting pins extending vertically from the respective intersections of the grid.
  • the tubes accommodated on the sides adjacent the frame are held by the partition walls and tube-supporting pins vertically provided on the intersections of the grid as in other tubes, the accommodation volume of tubes can be increased and smooth insertion and extraction of tubes become possible irrespective of the accommodation positions of the tubes. Thus the effects are very large.
  • FIG. 1 is a perspective view of a samples storage system for pharmaceutical development according to the present invention
  • FIG. 2 is top view of a storage rack shown in FIG. 1 ;
  • FIG. 3 is a cross-sectional view taken along the line III-III of the storage rack shown in FIG. 2 ;
  • FIG. 4 is an enlarged view of the portion encircled at IV in FIG. 3 ;
  • FIG. 5 is an enlarged perspective view of the portion encircled at V in FIG. 2 ; .
  • FIG. 6 is a top view of an ultramicrotube and a storage rack of the present invention shown in FIG. 5 ;
  • FIG. 7 is a cross-sectional view taken along the line VII-VII in FIG. 6 ;
  • FIG. 8 is a perspective view of conventional ultramicrotubes and a conventional storage rack.
  • FIG. 9 is a part of a cross-sectional view of other conventional ultramicrotubes and a storage rack.
  • the storage rack 110 which is one of components of a samples storage system for pharmaceutical development of the present invention, has a rack frame 114 and lower engagement partition walls 116 forming grid pattern of open-ended receptacles inside the rack frame. It is noted that the outermost walls 116, which are adjacent the rack frame, are spaced inwardly of the inside of the inner walls 118 of the rack 114, and the height of all of the partition walls 116 is less than the length of the associated ultramicrotubes.
  • Tube-supporting pins 112 extend vertically upwardly from the respective intersections of the grid.
  • the pins 112 taper upwardly from the intersections to guide the ultramicrotubes into the receptacles when loading the rack., and the ultramicrotubes do not come into contact with the rack wall 118, and as shown in FIGS. 4 and 5 , the outermost side ultramicrotube 120 is held, like other ultramicrotubes, by lower engagement partition walls 116 forming grid pattern sections inside than the length of the respective ultramicrotubes and four tube supporting pins 112 vertically upwardly provided from the respective intersections of the grid of the engagement partition walls 116. Therefore, the outermost side ultramicrotube 120 does not come into contact with a rack side wall 118.
  • the ultramicrotube 120 has a rectangular hollow tubluar cross-section and is tapered toward a bottom surface 121 and corner portions 122 on the outer four side surfaces of the ultramicrotube 120 are chamfered.
  • the ultramicrotube 120 has step portions 124 forming a shoulder at positions where the ultramicrotube 120 abuts on upper surfaces of the engagement partition walls 116, and this shoulder prevents the ultramicrotube 120 from slipping down past the upper surfaces of the engagement partition walls 116.
  • the outer bottom surface of the ultramicrotube 120 is flat, the inner bottom surface 123 of the ultramicrotube 120 has inclined surfaces toward the center of the inner bottom, like a square pyramid. This shape makes the residues of solution extremely small when the solution in the ultramicrotube 120 is extracted by a pipet or the like.
  • tube locking convex projections 125 are provided on the respective outer four side surfaces at a lower portion of the ultramicrotube 120.
  • the tube locking convex projection 125 comes into contact with the upper surfaces of the engagement partition walls 116.
  • One or both of the engagement partition walls 116 and the tube locking convex projections 125 are elastically deformed so that the tube locking convex projections 125 are slipped down below the engagement partition walls 116. It is noted that since the outermost partition wall 116 is spaced from the frame side wall 118, the wall 116 is free to deflect, which enables the projection 125 to pass through the receptacle.
  • the ultramicrotube 120 can be inserted into the storage rack 110 by smaller force as compared with the conventional storage rack 910 for tubes shown in FIG. 9 for example. Further, once the tube locking convex projections 125 are slipped down below the engagement walls 116, even if vibration is applied to the storage rack 110, the ultramicrotube 120 does not come out of the storage rack 110. When a specified ultramicrotube 120 accommodated in the storage rack 110 is pulled out through the top of the rack, it can be easily pulled out by sticking a probe against the bottom of the tube through the lower side of the storage rack 110. In the event it is desired to extract the microtube through the bottom of the rack, the step portions 124 on the microtube may be replaced by convex projections similar to the projections 125.
  • the tube locking convex projections are provided on four side surfaces of the lower portion of the ultramicrotubes 120 at the same distance from the bottom surface of the ultramicrotube 120.
  • various examples of numbers, sizes and distances from the bottom and the like of the tube locking convex projections are considered.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Claims (2)

  1. Système de stockage d'échantillons (100) pour le développement pharmaceutique comprenant des tubes (120) dans lesquels les échantillons pour le développement pharmaceutique sont hermétiquement enfermés et un râtelier de stockage (110) pour loger verticalement une pluralité desdits tubes (120) selon un modèle de grille, caractérisé en ce que :
    lesdits tubes (120) ont une section transversale tubulaire creuse rectangulaire qui est progressivement rétrécie vers la partie inférieure du tube (120) et quatre côtés avec des parties de coin chanfreinées (122) sur les surfaces externes, et
    ledit râtelier de stockage (110) a un châssis (114) et des parois de séparation de mise en prise (116) se coupant les unes par rapport aux autres et formant des sections de modèle de grille à l'intérieur dudit châssis de râtelier (114), lesdites parois (116) ayant une hauteur plus petite que la longueur desdits tubes (120),
    lesdites parois de séparation de grille (116) ont des broches de support de tube (112) s'étendant verticalement à partir des intersections respectives des parois de séparation de grille (116), dans lequel lesdites broches (112) sont progressivement rétrécies vers le haut afin de guider les tubes (120) dans lesdits réceptacles (113) pendant l'insertion des tubes (120) dans lesdits réceptacles (113), moyennant quoi :
    la totalité desdits tubes (120), comprenant les tubes (120) logés de manière adjacente audit châssis (114) est maintenue par lesdites parois de séparation de grille (116) et lesdites broches de support de tube (112),
    dans lequel lesdites parois de séparation (116) coopèrent pour former des réceptacles à extrémité ouverte (113) pour l'association avec lesdits tubes (120),
    chacun desdits tubes (120) ayant un épaulement (124) au niveau de sa périphérie dans lesdites surfaces latérales et une partie convexe (125) espacée selon une distance sélectionnée au-dessous dudit épaulement (124), ladite distance sélectionnée n'étant pas inférieure à la hauteur desdites parois de séparation (116), et dans lequel en outre :
    au moins l'une parmi ladite surface latérale et la paroi de séparation associée (116) est élastiquement déformable pour permettre audit épaulement (124) et à ladite partie convexe (125) de mettre en prise la partie supérieure et le fond de ladite paroi de séparation (116) pour effectuer une mise en prise de blocage amovible dudit tube (120) dans ledit réceptacle à extrémité ouverte (113).
  2. Système (100) selon la revendication 1, dans lequel ladite grille des parois de séparation (116) a des parois situées le plus à l'extérieur (116) adjacentes audit châssis (114), lesdites parois situées le plus à l'extérieur (116) étant espacées dudit châssis (114) et pouvant être déviées afin de faciliter l'insertion et le retrait desdits tubes (120) dans et des réceptacles à extrémité ouverte (113) formés par lesdites parois situées le plus à l'extérieur (115).
EP07003806A 2006-05-01 2007-02-23 Système de stockage d'échantillons pour le développement pharmaceutique Active EP1852187B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006127835A JP4749222B2 (ja) 2006-05-01 2006-05-01 創薬用試料保管システム

Publications (2)

Publication Number Publication Date
EP1852187A1 EP1852187A1 (fr) 2007-11-07
EP1852187B1 true EP1852187B1 (fr) 2010-10-13

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EP07003806A Active EP1852187B1 (fr) 2006-05-01 2007-02-23 Système de stockage d'échantillons pour le développement pharmaceutique

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US (1) US20070251892A1 (fr)
EP (1) EP1852187B1 (fr)
JP (1) JP4749222B2 (fr)
DE (1) DE602007009747D1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4473189B2 (ja) * 2005-07-22 2010-06-02 株式会社椿本チエイン 創薬用試料保管システム
US20140158645A1 (en) * 2012-08-03 2014-06-12 Thomas Concepts, LLC System and Method Related to a Storage and Retrieval Device for Clasping Mechanisms
JP5860908B2 (ja) * 2014-01-10 2016-02-16 株式会社椿本チエイン ワーク把持装置

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB758517A (en) * 1953-03-21 1956-10-03 Eric Clifford Turner Improved bottle container
JPS434518Y1 (fr) * 1964-09-09 1968-02-27
US4154795A (en) * 1976-07-23 1979-05-15 Dynatech Holdings Limited Microtest plates
US4948564A (en) * 1986-10-28 1990-08-14 Costar Corporation Multi-well filter strip and composite assemblies
JPH04121239U (ja) * 1991-02-16 1992-10-29 武内プレス工業株式会社 通 箱
US5514343A (en) * 1994-06-22 1996-05-07 Nunc, As Microtitration system
DE904841T1 (de) * 1997-09-29 2001-10-25 Hoffmann La Roche System zur Handhabung von Verbindungen, bestehend aus Gefässen und Trägern
EP1477226A1 (fr) * 2003-05-13 2004-11-17 The Automation Partnership (Cambridge) Limited Eprouvette
JP4356109B2 (ja) * 2004-01-23 2009-11-04 学校法人早稲田大学 マイクロリアクタの製造方法
JP4473189B2 (ja) * 2005-07-22 2010-06-02 株式会社椿本チエイン 創薬用試料保管システム

Also Published As

Publication number Publication date
DE602007009747D1 (de) 2010-11-25
JP2007297111A (ja) 2007-11-15
US20070251892A1 (en) 2007-11-01
EP1852187A1 (fr) 2007-11-07
JP4749222B2 (ja) 2011-08-17

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