EP1830947A4 - PURIFICATION OF IMMUNOGLOBULINS - Google Patents

PURIFICATION OF IMMUNOGLOBULINS

Info

Publication number
EP1830947A4
EP1830947A4 EP05815565A EP05815565A EP1830947A4 EP 1830947 A4 EP1830947 A4 EP 1830947A4 EP 05815565 A EP05815565 A EP 05815565A EP 05815565 A EP05815565 A EP 05815565A EP 1830947 A4 EP1830947 A4 EP 1830947A4
Authority
EP
European Patent Office
Prior art keywords
immunoglobulins
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05815565A
Other languages
German (de)
French (fr)
Other versions
EP1830947A1 (en
Inventor
Hans Berg
Hans J Johansson
Gunnar Malmquist
Per-Mikael Aaberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Global Life Sciences Solutions USA LLC
Original Assignee
GE Healthcare Bio Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36588164&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1830947(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from SE0403057A external-priority patent/SE0403057D0/en
Application filed by GE Healthcare Bio Sciences Corp filed Critical GE Healthcare Bio Sciences Corp
Publication of EP1830947A1 publication Critical patent/EP1830947A1/en
Publication of EP1830947A4 publication Critical patent/EP1830947A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Fodder In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP05815565A 2004-12-14 2005-12-12 PURIFICATION OF IMMUNOGLOBULINS Withdrawn EP1830947A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0403057A SE0403057D0 (en) 2004-12-14 2004-12-14 Purification of immunoglobulins
US63831604P 2004-12-22 2004-12-22
PCT/SE2005/001900 WO2006065208A1 (en) 2004-12-14 2005-12-12 Purification of immunoglobulins

Publications (2)

Publication Number Publication Date
EP1830947A1 EP1830947A1 (en) 2007-09-12
EP1830947A4 true EP1830947A4 (en) 2012-04-18

Family

ID=36588164

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05815565A Withdrawn EP1830947A4 (en) 2004-12-14 2005-12-12 PURIFICATION OF IMMUNOGLOBULINS

Country Status (5)

Country Link
EP (1) EP1830947A4 (en)
JP (1) JP5787461B2 (en)
AU (1) AU2005317279C1 (en)
CA (1) CA2586803C (en)
WO (1) WO2006065208A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3050963B1 (en) 2005-03-31 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Process for production of polypeptide by regulation of assembly
CA2647846C (en) 2006-03-31 2016-06-21 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
CN105177091A (en) 2006-03-31 2015-12-23 中外制药株式会社 Antibody modification method for purifying bispecific antibody
EP2066419B1 (en) 2006-09-29 2015-11-11 GE Healthcare Bio-Sciences AB Chromatography ligand comprising domain c from staphyloccocus aureus protein a for antibody isolation
SG149759A1 (en) * 2007-07-10 2009-02-27 Millipore Corp Media for affinity chromatography
CN106519025B (en) 2007-09-26 2021-04-23 中外制药株式会社 Method for changing isoelectric point of antibody by using amino acid substitution of CDR
KR102339457B1 (en) 2007-09-26 2021-12-14 추가이 세이야쿠 가부시키가이샤 Modified antibody constant region
US8277649B2 (en) * 2009-12-14 2012-10-02 General Electric Company Membranes and associated methods for purification of antibodies
EP2543730B1 (en) 2010-03-04 2018-10-31 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
AU2011222991B2 (en) 2010-03-05 2015-07-16 Boehringer Ingelheim International Gmbh Selective enrichment of antibodies
CN102388061A (en) * 2010-03-17 2012-03-21 松下电器产业株式会社 A method for binding a protein consisting of protein a or consisting of at least one domain of the a to e domains of the protein a to the substrate
US8859294B2 (en) 2010-03-17 2014-10-14 Panasonic Corporation Method for binding a protein consisting of protein A or consisting of at least one domain of the A to E domains of the protein A to the substrate
KR20130018256A (en) 2010-03-31 2013-02-20 제이에스알 가부시끼가이샤 Filler for affinity chromatography
CN102834407B (en) 2010-03-31 2016-01-20 Jsr株式会社 Affinity chromatography weighting agent
RU2620071C2 (en) 2010-11-17 2017-05-22 Чугаи Сеияку Кабушики Каиша Multispecific antigen-binding molecule with alternate function to blood coagulation factor viii function
TWI807362B (en) 2010-11-30 2023-07-01 日商中外製藥股份有限公司 cell damage-inducing therapeutics
WO2015030094A1 (en) 2013-08-30 2015-03-05 株式会社カネカ Fab REGION-BINDING PEPTIDE
US9448243B2 (en) * 2013-09-04 2016-09-20 Sten Ohlson Weak affinity chromatography
JP6230853B2 (en) * 2013-09-06 2017-11-15 株式会社日立製作所 Protein purification method and purification apparatus
CN105764922B (en) 2013-09-27 2020-07-17 中外制药株式会社 Preparation method of polypeptide heteromultimer
US20170043320A1 (en) 2013-11-27 2017-02-16 Jsr Corporation Solid-phase carrier, production method for solid-phase carrier, carrier for affinity refining, production method for filler for affinity chromatography, filler for affinity chromatography, chromatography column, and refining method
JP6653654B2 (en) 2014-01-17 2020-02-26 レプリゲン・コーポレイションＲｅｐｌｉｇｅｎ Ｃｏｒｐｏｒａｔｉｏｎ Chromatography column sterilization
EP3160982B1 (en) 2014-06-24 2020-10-28 Cytiva BioProcess R&D AB Chromatography method
US20170145051A1 (en) 2014-06-27 2017-05-25 Jsr Corporation Carrier for affinity chromatography
US20170334947A1 (en) * 2014-08-28 2017-11-23 Kaneka Corporation Affinity separation matrix for fab region-containing peptide
EP3252158A4 (en) 2015-01-26 2018-07-18 Kaneka Corporation Mutant immunoglobulin kappa chain variable region-binding peptide
JPWO2016121701A1 (en) 2015-01-26 2017-11-09 株式会社カネカ Affinity separation matrix for protein purification containing immunoglobulin κ chain variable region
WO2016159213A1 (en) 2015-04-01 2016-10-06 中外製薬株式会社 Method for producing polypeptide hetero-oligomer
CA3004288C (en) * 2015-12-28 2025-05-27 Chugai Seiyaku Kabushiki Kaisha Method for promoting efficiency of purification of fc region-containing polypeptide
TWI820000B (en) 2016-04-28 2023-11-01 日商中外製藥股份有限公司 Antibody-containing preparations
WO2017195638A1 (en) 2016-05-09 2017-11-16 株式会社カネカ Method for refining antibody or antibody fragment containing κ-chain variable region
WO2017195641A1 (en) * 2016-05-11 2017-11-16 株式会社カネカ Method for producing affinity separation matrix, and affinity separation matrix
GB201703116D0 (en) * 2017-02-27 2017-04-12 Ge Healthcare Bioprocess R&D Ab A seperation matrix and a method of seperating antibodies
AR113816A1 (en) 2017-11-01 2020-06-17 Chugai Pharmaceutical Co Ltd VARIANTS AND ISOFORMS OF ANTIBODIES WITH REDUCED BIOLOGICAL ACTIVITY

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
US5089605A (en) * 1987-03-13 1992-02-18 Repligen Corporation Immobilized immunoglobulin-binding proteins
US5445732A (en) * 1992-06-19 1995-08-29 Sepracor Inc. Passivated porous polymer supports and methods for the preparation and use of same
EP0693085B1 (en) * 1993-03-29 2001-10-31 Minnesota Mining And Manufacturing Company Method of coupling ligands within porous supports (p.e. azlactone) and uses thereof
SE9503925D0 (en) * 1995-11-07 1995-11-07 Pharmacia Biotech Ab Separation medium for IgG
SE9601368D0 (en) * 1996-04-11 1996-04-11 Pharmacia Biotech Ab Process for the production of a porous cross-linked polysaccharide gel
DE69835275T2 (en) * 1997-01-07 2007-07-19 Kaneka Corp. ABSORBENT FOR CLEANING BODY FLUIDS
SE9700383D0 (en) * 1997-02-04 1997-02-04 Pharmacia Biotech Ab An adsorption / separation method and a medium for adsorption / separation
SE0004929D0 (en) * 2000-12-29 2000-12-29 Apbiotech Ab A method for producing liquid chromatography matrices
SE0200943D0 (en) * 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
SE0300482D0 (en) * 2003-02-21 2003-02-21 Amersham Biosciences Ab Inorganic beads with hierarchical pore structures
US7700743B2 (en) * 2003-07-22 2010-04-20 Millipore Corporation Immobilised affinity medium and its use in separation
US20080312425A1 (en) * 2004-08-30 2008-12-18 Lonza Biologics Plc. Ion Exchange Chromatography and Purification of Antibodies

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "MabSelect Xtra - Recombinant protein A-based, high-capacity affinity medium", 1 November 2004 (2004-11-01), Uppsala, pages 1 - 8, XP055015044, Retrieved from the Internet <URL:http://www.gelifesciences.co.jp/catalog/pdf/11001157.pdf> [retrieved on 20111216] *
ANONYMOUS: "Protein A Agarose Kit Catalogue No. 553-50-00", 1 September 2004 (2004-09-01), Gaithersburg, MD, pages 1 - 3, XP055014986, Retrieved from the Internet <URL:http://web.archive.org/web/20040901150500/http://www.kpl.com/docs/datasheet/5535000.PDF> [retrieved on 20111215] *
See also references of WO2006065208A1 *

Also Published As

Publication number Publication date
JP2008523140A (en) 2008-07-03
JP5787461B2 (en) 2015-09-30
WO2006065208A1 (en) 2006-06-22
CA2586803A1 (en) 2006-06-22
AU2005317279A1 (en) 2006-06-22
AU2005317279C1 (en) 2014-07-17
AU2005317279B2 (en) 2011-02-24
CA2586803C (en) 2012-12-11
EP1830947A1 (en) 2007-09-12

Similar Documents

Publication Publication Date Title
EP1830947A4 (en) PURIFICATION OF IMMUNOGLOBULINS
MA28541B1 (en) IMMUNOGLOBULIN
EP1771786A4 (en) MULTIFRAITEMENT OF SAMPLES
CY2016035I2 (en) THERAPEUTIC USE OF ANTI-CS1 ANTIBODIES
DK1711530T3 (en) Nogo-A neutralizing immunoglobulins for the treatment of neurological disorders
DK1944322T3 (en) Treatment of TNFalfa-related diseases
DK1476162T3 (en) Controlled synthesis of ziprasidone
EE200300509A (en) Antibodies to VLA-1
DK1587542T3 (en) Use of anti-CD100 antibodies
DK1592384T3 (en) Cop 1 for the treatment of inflammatory bowel diseases
EP1765336A4 (en) INHIBITORS OF ANGIOGENESIS
EP1894372A4 (en) ROUTING OF INTER-DOMAIN CALLS
EP1752150A4 (en) PREPARATION OF IRINOTECAN
EP1746141A4 (en) COMPOSITION FOR THICKENING
DK1578774T3 (en) PURIFICATION OF IMMUNOGLOBULINES
EP1727065A4 (en) SEQUENCER OF EVENTS
DK1377544T3 (en) Purification of 2-Nitro-4-Methylsulfonylbenzoic acid
DK1687297T3 (en) TRIAZINDIMATES FOR THE TREATMENT OF AUTO-IMMUNE DISEASES
MA28812B1 (en) COMBINATIONS OF EPOTHILONE
ITMI20041981A1 (en) &#34;DC / DC CONVERTER&#34;
DK1289945T3 (en) Aniline disulfide derivatives for the treatment of allergic diseases
FR2873746B1 (en) EXHAUST LINE ELEMENT
DK2301576T3 (en) Therapeutic use of anti-CS1 antibodies
EP1627051A4 (en) REGULATION OF ACHERON EXPRESSION
NO20035282L (en) Use of polyclonal immunoglobulins

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20070514

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20120320

RIC1 Information provided on ipc code assigned before grant

Ipc: B01D 15/38 20060101ALI20120314BHEP

Ipc: B01J 2/00 20060101AFI20120314BHEP

Ipc: C07K 1/22 20060101ALI20120314BHEP

17Q First examination report despatched

Effective date: 20130118

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20130730