EP1819735A1 - Anticorps ctla-4 et inhibiteur de l'aromatase ou traitement combine du cancer du sein - Google Patents
Anticorps ctla-4 et inhibiteur de l'aromatase ou traitement combine du cancer du seinInfo
- Publication number
- EP1819735A1 EP1819735A1 EP05798369A EP05798369A EP1819735A1 EP 1819735 A1 EP1819735 A1 EP 1819735A1 EP 05798369 A EP05798369 A EP 05798369A EP 05798369 A EP05798369 A EP 05798369A EP 1819735 A1 EP1819735 A1 EP 1819735A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- antibody
- seq
- amino acid
- acid sequence
- ctla4
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C07—ORGANIC CHEMISTRY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- A—HUMAN NECESSITIES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne l'administration d'un anticorps d'un anti-CTLA4, en particulier des anticorps humains au CTLA4 humain, par exemple ceux présentant des séquences d'acides aminés des anticorps 3.1.1, 4.1.1, 4.8.1, 4.10.2, 4.13.1, 4.14.3, 6.1.1, 11.2.1, 11.6.1, 11.7.1, 12.3.1.1, 12.9.1.1, et 10DI (MDX-010), en combinaison avec un inhibiteur de l'aromatase, pour le traitement du cancer du sein. Plus précisément, l'invention concerne l'administration d'un anticorps anti-CTLA4 et de l'exemestane pour le traitement du cancer du sein.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62485604P | 2004-11-04 | 2004-11-04 | |
| PCT/IB2005/003307 WO2006048749A1 (fr) | 2004-11-04 | 2005-10-24 | Anticorps ctla-4 et inhibiteur de l'aromatase ou traitement combine du cancer du sein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1819735A1 true EP1819735A1 (fr) | 2007-08-22 |
Family
ID=35825412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP05798369A Ceased EP1819735A1 (fr) | 2004-11-04 | 2005-10-24 | Anticorps ctla-4 et inhibiteur de l'aromatase ou traitement combine du cancer du sein |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1819735A1 (fr) |
| JP (1) | JP2008518902A (fr) |
| KR (1) | KR20070067702A (fr) |
| CN (1) | CN101052655A (fr) |
| AR (1) | AR053651A1 (fr) |
| AU (1) | AU2005300315A1 (fr) |
| BR (1) | BRPI0515735A2 (fr) |
| CA (1) | CA2586844A1 (fr) |
| IL (1) | IL182244A0 (fr) |
| MX (1) | MX2007003804A (fr) |
| NO (1) | NO20072576L (fr) |
| RU (1) | RU2007114111A (fr) |
| TW (1) | TW200621804A (fr) |
| WO (1) | WO2006048749A1 (fr) |
| ZA (1) | ZA200702577B (fr) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2605796A1 (fr) * | 2005-04-25 | 2006-11-02 | Pfizer Products Inc. | Compositions pharmaceutiques et methodes comprenant une combinaison d'un modulateur selectif du recepteur de l'oestrogene et d'un inhibiteur de l'aromatase |
| US20090117132A1 (en) * | 2005-07-07 | 2009-05-07 | Pfizer, Inc. | Anti-Ctla-4 Antibody and Cpg-Motif-Containing Synthetic Oligodeoxynucleotide Combination Therapy for Cancer Treatment |
| US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
| CA2647282A1 (fr) * | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Polytherapie a base d'un anticorps anti-ctla4 |
| AU2009204194A1 (en) | 2008-01-08 | 2009-07-16 | Bristol-Myers Squibb Company | Combination of anti-CTLA4 antibody with tubulin modulating agents for the treatment of proliferative diseases |
| WO2010014784A2 (fr) | 2008-08-01 | 2010-02-04 | Bristol-Myers Squibb Company | Combinaison d'anticorps anti-ctla4 avec divers régimes thérapeutiques pour un traitement synergétique de maladies prolifératives |
| US8829173B2 (en) | 2008-09-26 | 2014-09-09 | Tocagen Inc. | Recombinant vectors |
| CN105624193B (zh) | 2008-09-26 | 2021-07-13 | 索元生物医药(美国)有限公司 | 重组载体 |
| NO2344540T3 (fr) | 2008-10-02 | 2018-04-28 | ||
| EP2456790A1 (fr) * | 2009-07-20 | 2012-05-30 | Bristol-Myers Squibb Company | Combinaison d un anticorps anti-ctla-4 avec divers régimes de traitement pour le traitement synergique de maladies prolifératives |
| CN103476943A (zh) | 2011-03-10 | 2013-12-25 | 普罗维克图斯药品公司 | 用于增强治疗癌症的局部和全身性免疫调节疗法的组合 |
| AU2012302051B2 (en) | 2011-08-30 | 2017-04-27 | Astex Pharmaceuticals, Inc. | Decitabine derivative formulations |
| DK2766040T3 (da) * | 2011-10-14 | 2019-07-22 | Hoffmann La Roche | Pertuzumab, trastuzumab, docetaxel og carboplatin til behandling af brystkræft i et tidligt stadie |
| DK2844282T3 (da) | 2012-05-04 | 2019-07-15 | Pfizer | Prostata-associerede antigener og vaccine-baserede immunterapiregimener |
| CN103768596B (zh) * | 2012-10-17 | 2016-06-22 | 苏州丁孚靶点生物技术有限公司 | 用于肿瘤治疗的组合产品、其用途及相关方法 |
| JP6419706B2 (ja) | 2012-10-25 | 2018-11-07 | トカジェン インコーポレーテッド | ミニプロモーターカセットを含むレトロウイルスベクター |
| SG10201707135RA (en) | 2013-03-01 | 2017-10-30 | Astex Pharmaceuticals Inc | Drug combinations |
| EA037890B1 (ru) * | 2013-10-18 | 2021-06-01 | Ридженерон Фармасьютикалз, Инк. | Способы и композиции, включающие комбинацию антагониста vegf и анти-ctla-4 антитела |
| EP3316685A4 (fr) | 2015-07-02 | 2019-03-13 | Otsuka Pharmaceutical Co., Ltd. | Compositions pharmaceutiques lyophilisées |
| AU2016317936A1 (en) | 2015-09-04 | 2018-03-08 | Tocagen Inc. | Recombinant vectors comprising 2A peptide |
| CN106883298B (zh) | 2015-12-16 | 2021-12-17 | 上海康岱生物医药技术股份有限公司 | 双特异性偶联抗体及其制法和用途 |
| EP3400292B1 (fr) | 2016-01-08 | 2020-08-26 | Replimune Limited | Utilisation d'un virus oncolytique pour traiter le cancer |
| US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| TWI784957B (zh) | 2016-06-20 | 2022-12-01 | 英商克馬伯有限公司 | 免疫細胞介素 |
| CN109906088A (zh) * | 2016-08-26 | 2019-06-18 | 奥野哲治 | 微血管血流减少剂及其应用 |
| WO2018098352A2 (fr) | 2016-11-22 | 2018-05-31 | Jun Oishi | Ciblage d'expression du point de contrôle immunitaire induit par kras |
| FI3589661T3 (fi) | 2017-03-02 | 2024-01-31 | Genentech Inc | Her2-positiivisen rintasyövän adjuvanttihoito |
| WO2018167780A1 (fr) * | 2017-03-12 | 2018-09-20 | Yeda Research And Development Co. Ltd. | Méthodes de diagnostic et de traitement du cancer |
| WO2019025863A2 (fr) | 2017-08-03 | 2019-02-07 | Otsuka Pharmaceutical Co., Ltd. | Composé médicamenteux et ses procédés de purification |
| WO2021173870A1 (fr) * | 2020-02-27 | 2021-09-02 | University Of Washington | Composition et procédé pour préparer une suspension injectable à action prolongée contenant de multiples médicaments anticancéreux |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL149701A0 (en) * | 2001-05-23 | 2002-11-10 | Pfizer Prod Inc | Use of anti-ctla-4 antibodies |
-
2005
- 2005-10-24 MX MX2007003804A patent/MX2007003804A/es unknown
- 2005-10-24 CN CNA2005800377929A patent/CN101052655A/zh active Pending
- 2005-10-24 BR BRPI0515735-8A patent/BRPI0515735A2/pt not_active IP Right Cessation
- 2005-10-24 CA CA002586844A patent/CA2586844A1/fr not_active Abandoned
- 2005-10-24 EP EP05798369A patent/EP1819735A1/fr not_active Ceased
- 2005-10-24 JP JP2007538539A patent/JP2008518902A/ja not_active Withdrawn
- 2005-10-24 KR KR1020077010096A patent/KR20070067702A/ko not_active Application Discontinuation
- 2005-10-24 AU AU2005300315A patent/AU2005300315A1/en not_active Abandoned
- 2005-10-24 WO PCT/IB2005/003307 patent/WO2006048749A1/fr active Application Filing
- 2005-10-24 RU RU2007114111/13A patent/RU2007114111A/ru unknown
- 2005-11-01 TW TW094138271A patent/TW200621804A/zh unknown
- 2005-11-02 AR ARP050104588A patent/AR053651A1/es not_active Application Discontinuation
-
2007
- 2007-03-27 IL IL182244A patent/IL182244A0/en unknown
- 2007-03-28 ZA ZA200702577A patent/ZA200702577B/en unknown
- 2007-05-21 NO NO20072576A patent/NO20072576L/no not_active Application Discontinuation
Non-Patent Citations (1)
| Title |
|---|
| See references of WO2006048749A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200702577B (en) | 2008-07-30 |
| AR053651A1 (es) | 2007-05-16 |
| AU2005300315A1 (en) | 2006-05-11 |
| WO2006048749A1 (fr) | 2006-05-11 |
| RU2007114111A (ru) | 2008-12-10 |
| NO20072576L (no) | 2007-08-03 |
| TW200621804A (en) | 2006-07-01 |
| CN101052655A (zh) | 2007-10-10 |
| JP2008518902A (ja) | 2008-06-05 |
| KR20070067702A (ko) | 2007-06-28 |
| MX2007003804A (es) | 2007-04-23 |
| BRPI0515735A2 (pt) | 2011-10-11 |
| CA2586844A1 (fr) | 2006-05-11 |
| IL182244A0 (en) | 2007-09-20 |
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