EP1810819A1 - Device and method for monitoring the production of tablets in a rotary tablet press - Google Patents

Device and method for monitoring the production of tablets in a rotary tablet press Download PDF

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Publication number
EP1810819A1
EP1810819A1 EP06026851A EP06026851A EP1810819A1 EP 1810819 A1 EP1810819 A1 EP 1810819A1 EP 06026851 A EP06026851 A EP 06026851A EP 06026851 A EP06026851 A EP 06026851A EP 1810819 A1 EP1810819 A1 EP 1810819A1
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EP
European Patent Office
Prior art keywords
temperature
tablets
machine computer
measuring
tablet
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EP06026851A
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German (de)
French (fr)
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EP1810819B1 (en
Inventor
Ingo Schmidt
Werner Seifert
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Fette GmbH
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Fette GmbH
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/005—Control arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/34—Heating or cooling presses or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets

Definitions

  • the invention relates to a device for monitoring the production of tablets in a rotary press according to the preamble of patent claim 1.
  • Rotary presses are well known and widely used in the pharmaceutical industry. They have a rotor, which is usually driven about a vertical axis of rotation and has upper and lower punches, dies, die plate and cam systems and at least one printing station. When the rotor rotates, the curve system ensures vertical positioning of the upper and lower punches on the pitch circle.
  • the filling of the matrices with powdered molding material takes place with the aid of suitable filling systems, for example a stirring blade device or a filling shoe, whereby the matrices are filled continuously while the rotor rotates.
  • suitable filling systems for example a stirring blade device or a filling shoe
  • the ejection of the tablets from the matrices takes place with the aid of the respective lower punch, which is actuated by an ejector curve.
  • a scraper wipes the tablets from the top of the die plate to a chute or the like, from which the tablets are fed to a filling station.
  • the computer converts the received pulses into further pulse trains whose pulses are at a distance from one another which corresponds to the distance of the press punches and the latter pulses are coordinated with the specified maximum pressing force values.
  • the computer can generate press force standard deviations for the purpose of evaluating the quality of production for each tablet.
  • thermolabile During production, a maximum temperature must not be exceeded. In order to achieve this, it is known to provide tablet presses with cooling devices or to cool the pressed material itself.
  • the invention has for its object to provide an apparatus and a method for monitoring the production of tablet presses in a rotary press or specify, with or a determination of the maximum temperature of the tablets during the pressing is possible.
  • a non-contact temperature measuring device which is in contact with a machine computer and has a measuring surface which is arranged between the pressing station and the tablet scraper is arranged in the baling chamber.
  • the measuring time of the temperature measuring device is so small that at least some tablets are measured with their temperature per revolution of the rotor or the die plate, e.g. every second or third tablet.
  • the measuring speed allows u.U. Also, to determine the temperature of each individual tablet, even if, as is usual, one hundred tablets per second are produced. Then the measuring time is e.g. 0.01 seconds or less.
  • the measuring surface of the device according to the invention is arranged so that it can detect the temperature radiation emitted by the tablet. This occurs at a time when the lower stamp begins to expel the tablet or has already ejected by a certain amount.
  • the measured temperature value is not the maximum value of the heating, because the maximum value occurs during the pressing and after the completion of the pressing process until the ejection of the tablet, a certain time passes, in which a cooling takes place. However, it is easily possible to deduce from the measured temperature value to the maximum temperature with the aid of the production speed and the cooling characteristic of the tablet material.
  • a tablet has been heated too much, then it can a suitable intervention in the tablet press on the machine computer to ensure that, for example, all tablets in which a predetermined temperature value has been exceeded, are discarded. Under certain circumstances, the production must be interrupted in order to change the production conditions so that no inadmissibly high heating occur more.
  • an infrared temperature measuring device is preferably provided. This can be connected via a line or wirelessly to the machine computer for logging, monitoring or intervention in the operation of the press.
  • the rotor or the die plate is associated with a position sensor, as used for example for the Preßkraftmaschine to optionally correct the Preßkrafthong to the individual tablets.
  • a position sensor as used for example for the Preßkraftmaschine to optionally correct the Preßkrafthong to the individual tablets.
  • the temperature detection position of the tablets can be determined or specified. This means that a measurement via the temperature measuring only takes place when the respective tablet is in the temperature detection position.
  • the temperature measuring device can continuously measure temperatures, and the machine computer only evaluates the measurement signal that has been generated in the temperature detection position.
  • the temperature of the tablets is, for example, of 0.01 seconds or less using a non-contact temperature sensor with a very fast measuring time measured after the upper punches have left the die.
  • position signals for the matrices are generated for determining a temperature detection position.
  • the temperature data of the thermal sensor is related to the temperature detection positions.
  • more than one measurement per tablet can be made.
  • the respective energy introduced into a tablet can also be determined.
  • a part of a rotor 12 of a rotary press is indicated, which is driven to rotate about a vertical axis (not shown) and is located within a baling chamber.
  • the rotor 12 has a die plate 14 with individual die bores 16, each associated with a pair of dies, namely an upper punch 18 and a lower punch 20.
  • the dies 18, 20 cooperate with stationary cam members 22 which control the position of the punches as they rotate in each case pretend with the rotor 12.
  • a pair of Vordruckrollen 24 and pair of main pressure rollers 26 is shown in a pressing or printing station.
  • the pairs of pressure rollers 24, 26 carry out the pressing of the powder material within the die bores 16 with the aid of the intermediate pressing rams 18, 20.
  • the powder material 30 is in a filling shoe 32. This fills the individual matrices in succession with a predetermined filling quantity of powder, the filling quantity being determined by the position of the lower punches 20 in the die bores 16.
  • the punches 18, 20 are guided in suitable punch guides 34, 36 of the rotor 12.
  • the parts described are known per se.
  • the finished pressed tablets are ejected by means of the lower punch 20, wherein the upper punch 18 are already returned (see in particular Fig. 2).
  • a scraper element 38 then ensures that the ejected tablets 40 are deported from the top of the die plates 14 in the direction of a tablet removal.
  • a temperature sensor 42 is arranged above the pitch circle of the die bore 16, a temperature sensor 42 is arranged.
  • the mounting location of the sensor 42 is such that the respective upper punch 18 has already moved sufficiently far out of the die bore 16, so that space for the sensor 36 is present.
  • the previously pressed tablet 40 is still slightly inside the die bore and can be localized.
  • the temperature sensor 42 has a measuring surface, which faces the tablet 40. It is, for example, an infrared temperature sensor capable of measuring the temperature within a very short time, that is, within less than 0.01 second. For example, the current high speed press production speed is one hundred presses per second.
  • the temperature sensor 42 is connected to a machine computer 44.
  • the machine computer as known for tablet pressing per se, controls and regulates the operation of the press. It cooperates with an operating computer 46.
  • the shaft, not shown, of the rotor 12 is assigned a pulse generator 48, the signals of which are given to the machine computer 44.
  • the pulse generator 48 is about a known angle encoder, which gives a corresponding signal to the machine computer 44 in the smallest angular steps to determine the position of the individual die holes 16. This allows also determine the temperature detection position of the tablets relative to the temperature sensor 42.
  • the signals of the temperature sensor 42 go to the machine computer 44 and are evaluated there and forwarded to the control computer 46.
  • the evaluation process is position-dependent, that is, the temperature measured by the temperature sensor 42 is in each case assigned to a tablet. In this case, with the help of the temperature sensor 42 and a multiple measurement can be made. It is also possible to perform the measurement at interval intervals, the interval intervals being determined by the time it takes for a template bore to divide the arrays prior to the temperature sensing position to get into the temperature sensing position.
  • the determined data from the machine computer can be stored and stored in the operating computer 46 or displayed in a display device 50.
  • the temperature of the tablets measured with the temperature sensor 42 is not that occurring during the compression process. Immediately after compression, the temperature is maximum and gradually decays as the tablet is advanced with the die disc and then expelled. If you want to determine the maximum temperature, the cooling behavior of the tablet material is decisive and the time that passes from the printing station to the temperature detection position, once you ignore the cooling effect of the matrix. Of course, he can also be included in the calculation. With the help of this data can then be deduced the maximum temperature. Is this too high Measures must be taken to prevent temperature-labile tablet material from overheating.
  • the amount of heat depends on the specific heat capacity of a substance, its mass and the measured temperature.
  • the energy can be determined in this way in the machine computer 44. It can be used to optimize the production process for the tablets.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

The device has a pre-pressing roller and a main pressing roller for pressing of powder in matrix bores (16). A stripper unit (38) strips tablets from an upper side of a matrix plate (14). A temperature sensor (42) e.g. infrared measuring device, operatively stays in connection with a machine computer and has a measuring surface that is provided between the rollers and the unit. The sensor is arranged in a pressing area of a rotary tablet press, where measuring time of the sensor is obtained in such a manner that the some of the tablets are determined with their temperatures per revolution of the matrix plate.. An independent claim is also included for a method for monitoring the production of tablets in a rotary tablet press.

Description

Die Erfindung bezieht auf eine Vorrichtung zur Überwachung der Produktion von Tabletten in einer Rundläuferpresse nach dem Oberbegriff des Patentanspruchs 1.The invention relates to a device for monitoring the production of tablets in a rotary press according to the preamble of patent claim 1.

Rundläuferpressen sind allgemein bekannt und werden vielfältig in der pharmazeutischen Industrie eingesetzt. Sie weisen einen Rotor auf, der zumeist um eine vertikale Drehachse angetrieben ist und Ober- und Unterstempel, Matrizen, Matrizenscheibe und Kurvensysteme sowie mindestens eine Druckstation aufweist. Bei drehendem Rotor sorgt das Kurvensystem für die vertikale Positionierung von Ober- und Unterstempel am Teilkreis. Die Befüllung der Matrizen mit pulverförmigem Preßmaterial erfolgt mit Hilfe geeigneter Füllsysteme, beispielsweise einer Rührflügeleinrichtung oder einem Füllschuh, wodurch die Matrizen kontinuierlich bei drehendem Rotor befüllt werden. Am Teilkreis des Rotors befinden sich außerdem Vor- und Hauptdruckrollen mit deren Hilfe das Preßmaterial zu einer Tablette verpreßt wird. Das Auswerfen der Tabletten aus den Matrizen erfolgt mit Hilfe des jeweiligen Unterstempels, der von einer Auswerferkurve betätigt wird. Ein Abstreifer streift die Tabletten von der Oberseite der Matrizenscheibe zu einer Rutsche oder dergleichen, von der die Tabletten zu einer Befüllstation geführt werden.Rotary presses are well known and widely used in the pharmaceutical industry. They have a rotor, which is usually driven about a vertical axis of rotation and has upper and lower punches, dies, die plate and cam systems and at least one printing station. When the rotor rotates, the curve system ensures vertical positioning of the upper and lower punches on the pitch circle. The filling of the matrices with powdered molding material takes place with the aid of suitable filling systems, for example a stirring blade device or a filling shoe, whereby the matrices are filled continuously while the rotor rotates. At the pitch circle of the rotor are also pre-and main pressure rollers with the help of the press material is pressed into a tablet. The ejection of the tablets from the matrices takes place with the aid of the respective lower punch, which is actuated by an ejector curve. A scraper wipes the tablets from the top of the die plate to a chute or the like, from which the tablets are fed to a filling station.

Aus US 2004/0012781 A1 ist bekannt geworden, ein einer Tablettiermaschine zugeordnetes Reservoir für Pulver oder Granulat, aus dem die Tabletten gepreßt werden, mit einem Spektroskop auszustatten. Mit dessen Hilfe werden Homogenität und/oder Feuchte des Materials gemessen. Aus DE 697 18 811 T2 ist bekannt geworden, durch Laserbestrahlung von Medikamentenproben eine spektroskopische Analyse vorzunehmen. Das von dem durch die Bestrahlung gebildeten Plasma emittierte Licht wird von einem optischen System auf ein optisches Spektrometer gegeben. Aus US 5 504 332 und US 5 760 399 ist bekannt geworden, die Homogenität einer Tablettenpulvermischung zu prüfen. Diese Verfahren beruhen auf der Spektroskopie des bestrahlten Materials.Out US 2004/0012781 A1 It has become known to equip a tableting machine associated with a reservoir for powder or granules from which the tablets are pressed to provide a spectroscope. With its help, the homogeneity and / or humidity of the material are measured. Out DE 697 18 811 T2 It has become known to perform a spectroscopic analysis by laser irradiation of drug samples. The light emitted by the plasma formed by the irradiation is given from an optical system to an optical spectrometer. Out US 5,504,332 and US 5,760,399 It has become known to test the homogeneity of a tablet powder mixture. These methods are based on the spectroscopy of the irradiated material.

Aus DE 10 2004 008321 B3 ist bekannt geworden, mit Hilfe eines NIR- oder LIF-Sensors im Preßraum chemische und/oder mechanische Daten zu gewinnen, wobei der Meßvorgang von einem Maschinenrechner in Abhängigkeit von von einem Positionsgeber ermittelten Matrizenpositionen relativ zum Sensor ausgelöst wird. Mit Hilfe dieses Verfahrens lassen sich die Tabletten online auf eine Vielzahl von Qualitätsparametern prüfen, insbesondere die anteilsmäßige Zusammensetzung des Tablettenmaterials sowie auch deren Härte usw..Out DE 10 2004 008321 B3 It has become known to obtain chemical and / or mechanical data in the baling chamber with the aid of an NIR or LIF sensor, the measuring process being triggered by a machine computer as a function of die positions determined by a position sensor relative to the sensor. Using this method, the tablets can be tested online for a variety of quality parameters, in particular the proportionate composition of the tablet material as well as their hardness, etc.

Aus EP 0 431 269 B2 ist bekannt geworden, mit Hilfe eines Winkelimpulsgebers Preßkraftmeßwerte den Stempeln einer Rundläufertablettenpresse zuzuordnen. Die Messung der Preßkraft ermöglicht die Einhaltung von Qualitätskriterien, da bekanntlich die Preßkraft ein Maß für die Bruchneigung, das Tablettengewicht und die Tablettenhärte ist. Bei dem bekannten Verfahren wird ein Winkelimpulsgeber verwendet, der beim Umlauf der Matrizenscheibe einen gesonderten Umlaufimpuls auslöst. Ein codierter Signalgeber ist derart eingestellt, daß der Umlaufimpuls dann ausgelöst wird, wenn die Preßkraft eines bestimmten Preßstempels den maximalen Wert erreicht hat. Der Winkelimpulsgeber erzeugt pro Umdrehung mindestens eine fortlaufende Impulsreihe, die in einen Maschinenrechner eingegeben wird. Der Rechner wandelt die empfangenen Impulse in weitere Impulsreihen um, deren Impulse einen Abstand zueinander haben, der dem Abstand der Preßstempel entspricht und die letzteren Impulse werden mit den angegebenen maximalen Preßkraftwerten koordiniert. So kann der Rechner zur Ausgabe von Auswertungen Preßkraft-Standardabweichungen zur Bestimmung der Güte der Produktion für jede Tablette ermitteln.Out EP 0 431 269 B2 It has become known to assign pressing force values to the punches of a rotary tablet press with the aid of an angle pulse generator. The measurement of the pressing force allows compliance with quality criteria, since it is known that the pressing force is a measure of the tendency to fracture, the tablet weight and the tablet hardness is. In the known method, an angle encoder is used, which triggers a separate circulation pulse during circulation of the die plate. An encoded signal generator is set so that the circulation pulse is triggered when the pressing force of a particular ram has reached the maximum value. The angle encoder generates per revolution at least one continuous pulse series, which is input to a machine computer. The computer converts the received pulses into further pulse trains whose pulses are at a distance from one another which corresponds to the distance of the press punches and the latter pulses are coordinated with the specified maximum pressing force values. For example, the computer can generate press force standard deviations for the purpose of evaluating the quality of production for each tablet.

Während des Preßvorgangs wird naturgemäß Energie in die Tablette eingebracht, wobei sich diese erwärmt. Etliche zu verpressende Materialien sind thermolabil. Während der Produktion darf eine Maximaltemperatur nicht überschritten werden. Um dies zu erreichen, ist bekannt, Tablettenpressen mit Kühleinrichtungen auszurüsten oder das Preßmaterial selbst herunterzukühlen.During the pressing process naturally energy is introduced into the tablet, which heats up. Several materials to be pressed are thermolabile. During production, a maximum temperature must not be exceeded. In order to achieve this, it is known to provide tablet presses with cooling devices or to cool the pressed material itself.

Der Erfindung liegt die Aufgabe zugrunde, eine Vorrichtung und ein Verfahren zur Überwachung der Produktion von Tablettenpressen in einer Rundläuferpresse zu schaffen bzw. anzugeben, mit der bzw. dem eine Bestimmung der Maximaltemperatur der Tabletten während der Pressung möglich ist.The invention has for its object to provide an apparatus and a method for monitoring the production of tablet presses in a rotary press or specify, with or a determination of the maximum temperature of the tablets during the pressing is possible.

Diese Aufgabe wird durch eine Vorrichtung nach Anspruch 1 bzw. ein Verfahren nach Anspruch 5 gelöst.This object is achieved by a device according to claim 1 and a method according to claim 5.

Bei der erfindungsgemäßen Vorrichtung ist im Preßraum eine mit einem Maschinenrechner in Verbindung stehende berührungslos arbeitende Temperaturmeßvorrichtung angeordnet, die eine Meßfläche aufweist, die zwischen der Preßstation und dem Tablettenabstreifer angeordnet ist. Die Meßzeit der Temperaturmeßvorrichtung ist so klein, dass pro Umdrehung des Rotors bzw. der Matrizenscheibe mindestens einige Tabletten mit ihrer Temperatur gemessen werden, z.B. jede zweite oder dritte Tablette. Die Meßgeschwindigkeit erlaubt u.U. auch die Temperatur jeder einzelnen Tablette zu bestimmen, auch wenn, was üblich ist, hundert Tabletten pro Sekunde hergestellt werden. Dann beträgt die Meßzeit z.B. 0,01 Sekunden oder weniger.In the apparatus according to the invention, a non-contact temperature measuring device which is in contact with a machine computer and has a measuring surface which is arranged between the pressing station and the tablet scraper is arranged in the baling chamber. The measuring time of the temperature measuring device is so small that at least some tablets are measured with their temperature per revolution of the rotor or the die plate, e.g. every second or third tablet. The measuring speed allows u.U. Also, to determine the temperature of each individual tablet, even if, as is usual, one hundred tablets per second are produced. Then the measuring time is e.g. 0.01 seconds or less.

Die Meßfläche der erfindungsgemäßen Vorrichtung ist so angeordnet, daß sie die von der Tablette ausgehende Temperaturstrahlung erfassen kann. Dies geschieht zu einem Zeitpunkt, bei dem der Unterstempel beginnt, die Tablette auszustoßen bzw. bereits um einen bestimmten Betrag ausgestoßen hat. Der gemessene Temperaturwert ist nicht der maximale Wert der Erwärmung, weil der maximale Wert während des Preßvorgangs auftritt und nach Beendigung des Preßvorgangs bis zum Ausstoßen der Tablette eine gewisse Zeit vergeht, in der eine Abkühlung erfolgt. Es ist jedoch leicht möglich, mit Hilfe der Produktionsgeschwindigkeit und der Abkühlcharakteristik des Tablettenmaterials vom gemessenen Temperaturwert auf die Maximaltemperatur rückzuschließen. Ist eine Tablette zu stark erwärmt worden, kann dann durch einen geeigneten Eingriff in die Tablettenpresse über den Maschinenrechner dafür gesorgt werden, daß zum Beispiel alle Tabletten, bei denen ein vorgegebener Temperaturwert überschritten wurde, ausgesondert werden. Unter Umständen muß auch die Produktion unterbrochen werden, um die Produktionsbedingungen so zu verändern, daß keine unzulässig hohen Erwärmungen mehr auftreten.The measuring surface of the device according to the invention is arranged so that it can detect the temperature radiation emitted by the tablet. This occurs at a time when the lower stamp begins to expel the tablet or has already ejected by a certain amount. The measured temperature value is not the maximum value of the heating, because the maximum value occurs during the pressing and after the completion of the pressing process until the ejection of the tablet, a certain time passes, in which a cooling takes place. However, it is easily possible to deduce from the measured temperature value to the maximum temperature with the aid of the production speed and the cooling characteristic of the tablet material. If a tablet has been heated too much, then it can a suitable intervention in the tablet press on the machine computer to ensure that, for example, all tablets in which a predetermined temperature value has been exceeded, are discarded. Under certain circumstances, the production must be interrupted in order to change the production conditions so that no inadmissibly high heating occur more.

Nach einer Ausgestaltung der Erfindung ist vorzugsweise eine Infrarot-Temperaturmeßvorrichtung vorgesehen. Diese kann über eine Leitung oder drahtlos mit dem Maschinenrechner verbunden sein zwecks Protokollierung, Überwachung oder Eingriffs in den Betrieb der Presse.According to one embodiment of the invention, an infrared temperature measuring device is preferably provided. This can be connected via a line or wirelessly to the machine computer for logging, monitoring or intervention in the operation of the press.

Vorzugsweise ist dem Rotor bzw. der Matrizenscheibe ein Positionsgeber zugeordnet, wie er beispielsweise für die Preßkraftmessung eingesetzt wird, um gegebenenfalls die Preßkraftwerte zu den einzelnen Tabletten zu korrigieren. Mit Hilfe des Positionsgebers kann die Temperaturerfassungsposition der Tabletten bestimmt bzw. vorgegeben werden. Dies bedeutet, daß eine Messung über die Temperaturmeßvorrichtung jeweils nur dann erfolgt, wenn die jeweilige Tablette sich in der Temperaturerfassungsposition befindet. Alternativ kann die Temperaturmeßvorrichtung kontinuierlich Temperaturen messen, und der Maschinenrechner wertet nur das Meßsignal aus, das in der Temperaturerfassungsposition erzeugt worden ist.Preferably, the rotor or the die plate is associated with a position sensor, as used for example for the Preßkraftmessung to optionally correct the Preßkraftwerte to the individual tablets. With the help of the position sensor, the temperature detection position of the tablets can be determined or specified. This means that a measurement via the temperature measuring only takes place when the respective tablet is in the temperature detection position. Alternatively, the temperature measuring device can continuously measure temperatures, and the machine computer only evaluates the measurement signal that has been generated in the temperature detection position.

Bei dem Verfahren nach der Erfindung nach Anspruch 5 wird mit Hilfe eines berührungslos arbeitenden Temperatursensors mit sehr schneller Meßzeit, z.B. von 0,01 Sekunden oder kleiner die Temperatur z.B. der Tabletten gemessen, nachdem die Oberstempel die Matrize verlassen haben. Mit Hilfe eines Positionsgebers werden Positionssignale für die Matrizen erzeugt zur Bestimmung einer Temperaturerfassungsposition. Die Temperaturdaten des Thermosensors werden mit den Temperaturerfassungspositionen in Beziehung gesetzt. Mittels der bekannten Abkühlcharakteristik, dem Zeitpunkt der Temperaturmessung und dem Zeitpunkt der Pressung wird die maximale Temperatur der Tabletten bestimmt. Diese kann, wie erwähnt, im Maschinenrechner protokolliert werden. Findet eine unzulässige Abweichung statt, zum Beispiel in Form einer zu hohen maximalen Temperatur, müssen Gegenmaßnahmen eingeleitet werden, etwa durch Veränderung der Preßparameter, des Preßmaterials oder dergleichen. Gegebenenfalls muß die Produktion unterbrochen werden.In the method according to the invention according to claim 5, the temperature of the tablets is, for example, of 0.01 seconds or less using a non-contact temperature sensor with a very fast measuring time measured after the upper punches have left the die. With the aid of a position sensor, position signals for the matrices are generated for determining a temperature detection position. The temperature data of the thermal sensor is related to the temperature detection positions. By means of the known Abkühlcharakteristik, the time of temperature measurement and the time of pressing the maximum temperature of the tablets is determined. This can, as mentioned, be logged in the machine computer. If an impermissible deviation takes place, for example in the form of a too high maximum temperature, countermeasures must be initiated, for example by changing the pressing parameters, the pressing material or the like. If necessary, the production must be interrupted.

Nach einer Ausgestaltung der Erfindung kann pro Tablette auch mehr als eine Messung vorgenommen werden.According to one embodiment of the invention, more than one measurement per tablet can be made.

Mit Hilfe des erfindungsgemäßen Verfahrens kann auch die jeweilige in eine Tablette eingebrachte Energie bestimmt werden. Die Energiemenge kann z.B. nach der Beziehung Qi=c x m x t ermittelt werden, wobei c die spezifische Wärmekapazität des Tablettenmaterials ist, m die Masse der Tablette und t die maximale gemessene Temperatur. Qi ist dann der Wärmeinhalt bezogen auf 0° C nach der Pressung. Mit Hilfe der gemessenen bzw. errechneten Energiemenge läßt sich der Produktionsprozeß optimieren.With the aid of the method according to the invention, the respective energy introduced into a tablet can also be determined. The amount of energy can be determined, for example, according to the relationship Q i = cxmxt, where c is the specific heat capacity of the tablet material, m the mass of the tablet and t the maximum measured temperature. Q i is then the heat content based on 0 ° C after pressing. With the help of the measured or calculated amount of energy, the production process can be optimized.

Die Erfindung soll nachfolgend anhand eines Ausführungsbeispiels näher erläutert werden.

Fig. 1
zeigt einen Teil einer Rundläufertablettenpresse mit einem Temperatursensor.
Fig. 2
zeigt vergrößert einen Teil der Vorrichtung nach Fig. 1 mit einem zusätzlichen Blockschaltbild.
The invention will be explained in more detail with reference to an embodiment.
Fig. 1
shows a part of a rotary tablet press with a temperature sensor.
Fig. 2
shows enlarged part of the device of FIG. 1 with an additional block diagram.

In Fig. 1 ist ein Teil eines Rotors 12 einer Rundläuferpresse angedeutet, der um eine vertikale Achse drehend angetrieben ist (nicht gezeigt) und sich innerhalb eines Preßraums befindet. Der Rotor 12 weist eine Matrizenscheibe 14 auf mit einzelnen Matrizenbohrungen 16, denen jeweils ein Paar Preßstempel zugeordnet ist, nämlich ein Oberstempel 18 und ein Unterstempel 20. Die Preßstempel 18, 20 wirken mit stationären Kurvenelementen 22 zusammen, welche die Position der Stempel bei ihrer Drehung mit dem Rotor 12 jeweils vorgeben. In Fig. 1 ist ein Paar Vordruckrollen 24 und Paar Hauptdruckrollen 26 in einer Preß- oder Druckstation dargestellt. Die Druckrollenpaare 24, 26 führen mit Hilfe der dazwischen laufenden Preßstempel 18, 20 die Verpressung des Pulvermaterials innerhalb der Matrizenbohrungen 16 durch. Für die Zuführung des Pulvermaterials dient ein Fülltrichter 28, der Pulvermaterial 30 in einen Füllschuh 32 gibt. Dieser füllt die einzelnen Matrizen nacheinander mit einer vorgegebenen Füllmenge an Pulver, wobei die Füllmenge durch die Position der Unterstempel 20 in den Matrizenbohrungen 16 bestimmt ist. Die Stempel 18, 20 werden in geeigneten Stempelführungen 34, 36 des Rotors 12 geführt. Die beschriebenen Teile sind an sich bekannt.In Fig. 1, a part of a rotor 12 of a rotary press is indicated, which is driven to rotate about a vertical axis (not shown) and is located within a baling chamber. The rotor 12 has a die plate 14 with individual die bores 16, each associated with a pair of dies, namely an upper punch 18 and a lower punch 20. The dies 18, 20 cooperate with stationary cam members 22 which control the position of the punches as they rotate in each case pretend with the rotor 12. In Fig. 1, a pair of Vordruckrollen 24 and pair of main pressure rollers 26 is shown in a pressing or printing station. The pairs of pressure rollers 24, 26 carry out the pressing of the powder material within the die bores 16 with the aid of the intermediate pressing rams 18, 20. For the supply of the powder material is a hopper 28, the powder material 30 is in a filling shoe 32. This fills the individual matrices in succession with a predetermined filling quantity of powder, the filling quantity being determined by the position of the lower punches 20 in the die bores 16. The punches 18, 20 are guided in suitable punch guides 34, 36 of the rotor 12. The parts described are known per se.

Wie aus den Fign. 1 und 2 ferner ersichtlich, werden die fertig gepreßten Tabletten mit Hilfe der Unterstempel 20 ausgestoßen, wobei die Oberstempel 18 bereits rückgeführt sind (siehe insbesondere Fig. 2). Ein Abstreiferelement 38 sorgt dann dafür, daß die ausgestoßenen Tabletten 40 von der Oberseite der Matrizenscheiben 14 abgeschoben werden in Richtung einer Tablettenabfuhr.As shown in Figs. 1 and 2 also seen, the finished pressed tablets are ejected by means of the lower punch 20, wherein the upper punch 18 are already returned (see in particular Fig. 2). A scraper element 38 then ensures that the ejected tablets 40 are deported from the top of the die plates 14 in the direction of a tablet removal.

Oberhalb des Teilkreises der Matrizenbohrung 16 ist ein Temperatursensor 42 angeordnet. Der Anbringungsort des Sensors 42 ist derart, daß der jeweilige Oberstempel 18 sich bereits ausreichend weit aus der Matrizenbohrung 16 herausbewegt hat, so daß Platz für den Sensor 36 vorhanden ist. Andererseits befindet sich die zuvor gepreßt Tablette 40 noch etwas innerhalb der Matrizenbohrung und ist lokalisierbar. Der Temperatursensor 42 weist eine Meßfläche auf, welche der Tablette 40 zugekehrt ist. Er ist zum Beispiel ein Infrarot-Temperatursensor, der in der Lage ist, eine Temperaturmessung innerhalb kürzester Zeit zu bewerkstelligen, das heißt, innerhalb von weniger als 0,01 Sekunden. Die derzeitige Produktionsgeschwindigkeit bei Hochleistungspressen beträgt zum Beispiel einhundert Pressungen pro Sekunde. Der Temperatursensor 42 ist mit einem Maschinenrechner 44 verbunden. Der Maschinenrechner, wie er für das Tablettenpressen an sich bekannt ist, steuert und regelt den Betrieb der Presse. Er kooperiert mit einem Bedienrechner 46. Der nicht gezeigten Welle des Rotors 12 ist ein Impulsgeber 48 zugeordnet, dessen Signale auf den Maschinenrechner 44 gegeben werden. Der Impulsgeber 48 ist etwa ein bekannter Winkelencoder, der in kleinsten Winkelschritten ein entsprechendes Signal auf den Maschinenrechner 44 gibt zur Bestimmung der Position der einzelnen Matrizenbohrungen 16. Dadurch läßt sich auch die Temperaturerfassungsposition der Tabletten relativ zum Temperatursensor 42 ermitteln. Die Signale des Temperatursensors 42 gehen auf den Maschinenrechner 44 und werden dort ausgewertet und an den Bedienrechner 46 weitergeleitet. Der Auswertevorgang ist positionsabhängig, das heißt die vom Temperatursensor 42 gemessene Temperatur wird jeweils einer Tablette zugeordnet. Dabei kann mit Hilfe des Temperatursensors 42 auch eine Mehrfachmessung vorgenommen werden. Es ist auch möglich, die Messung in Intervallabständen durchzuführen, wobei die Intervallabstände bestimmt sind durch die Zeit, die eine Matrizenbohrung um eine Teilung der Matrizen vor der Temperaturerfassungsposition benötigt, um in die Temperaturerfassungsposition zu gelangen.Above the pitch circle of the die bore 16, a temperature sensor 42 is arranged. The mounting location of the sensor 42 is such that the respective upper punch 18 has already moved sufficiently far out of the die bore 16, so that space for the sensor 36 is present. On the other hand, the previously pressed tablet 40 is still slightly inside the die bore and can be localized. The temperature sensor 42 has a measuring surface, which faces the tablet 40. It is, for example, an infrared temperature sensor capable of measuring the temperature within a very short time, that is, within less than 0.01 second. For example, the current high speed press production speed is one hundred presses per second. The temperature sensor 42 is connected to a machine computer 44. The machine computer, as known for tablet pressing per se, controls and regulates the operation of the press. It cooperates with an operating computer 46. The shaft, not shown, of the rotor 12 is assigned a pulse generator 48, the signals of which are given to the machine computer 44. The pulse generator 48 is about a known angle encoder, which gives a corresponding signal to the machine computer 44 in the smallest angular steps to determine the position of the individual die holes 16. This allows also determine the temperature detection position of the tablets relative to the temperature sensor 42. The signals of the temperature sensor 42 go to the machine computer 44 and are evaluated there and forwarded to the control computer 46. The evaluation process is position-dependent, that is, the temperature measured by the temperature sensor 42 is in each case assigned to a tablet. In this case, with the help of the temperature sensor 42 and a multiple measurement can be made. It is also possible to perform the measurement at interval intervals, the interval intervals being determined by the time it takes for a template bore to divide the arrays prior to the temperature sensing position to get into the temperature sensing position.

Die ermittelten Daten aus dem Maschinenrechner können im Bedienrechner 46 abgelegt und gespeichert oder auch in einer Anzeigevorrichtung 50 angezeigt werden.The determined data from the machine computer can be stored and stored in the operating computer 46 or displayed in a display device 50.

Die mit dem Temperatursensor 42 gemessene Temperatur der Tabletten ist nicht diejenige, die während des Verpressungsvorgangs auftritt. Unmittelbar nach der Verpressung ist die Temperatur maximal und klingt allmählich ab, wenn die Tablette mit der Matrizenscheibe weiterbewegt und anschließend ausgestoßen wird. Will man die maximale Temperatur ermitteln, ist das Abkühlverhalten des Tablettenmaterials maßgebend sowie die Zeit, die vergeht von der Druckstation bis zur Temperaturfeststellposition, wenn man einmal den Kühleffekt der Matrize außer acht läßt. Selbstverständlich kann er auch in die Berechnung einbezogen werden. Mit Hilfe dieser Daten kann dann auf die maximale Temperatur rückgeschlossen werden. Ist diese zu hoch, müssen Maßnahmen ergriffen werden, um temperaturlabiles Tablettenmaterial an einer Überhitzung zu hindern.The temperature of the tablets measured with the temperature sensor 42 is not that occurring during the compression process. Immediately after compression, the temperature is maximum and gradually decays as the tablet is advanced with the die disc and then expelled. If you want to determine the maximum temperature, the cooling behavior of the tablet material is decisive and the time that passes from the printing station to the temperature detection position, once you ignore the cooling effect of the matrix. Of course, he can also be included in the calculation. With the help of this data can then be deduced the maximum temperature. Is this too high Measures must be taken to prevent temperature-labile tablet material from overheating.

Mit Hilfe der gezeigten Vorrichtung ist auch möglich, die aufgenommene Wärmemenge zu messen und damit auf die aufgenommene Energie rückzuschließen. Die Wärmemenge ist abhängig von der spezifischen Wärmekapazität eines Stoffes, seiner Masse und der gemessenen Temperatur. Die Energie kann auf diese Weise im Maschinenrechner 44 ermittelt werden. Sie kann dazu verwendet werden, den Produktionsprozeß für die Tabletten zu optimieren.With the help of the device shown is also possible to measure the amount of heat absorbed and thus infer the absorbed energy. The amount of heat depends on the specific heat capacity of a substance, its mass and the measured temperature. The energy can be determined in this way in the machine computer 44. It can be used to optimize the production process for the tablets.

Claims (7)

Vorrichtung zur Überwachung der Produktion von Tabletten in einer Rundläuferpresse, mit Matrizenbohrungen in einer Matrizenscheibe zur Aufnahme eines zu verpressenden Pulvers, Ober- und Unterstempeln, einer Druckstation zum Pressen des Pulvers in den Matrizenbohrungen mittels Ober- und Unterstempeln, einem Tablettenabstreifer zum Abstreifen der von den Unterstempeln ausgestoßenen Tabletten von der Oberseite der Matrizenscheibe und einem Maschinenrechner, dadurch gekennzeichnet, daß im Pressenraum der Rundläuferpresse eine mit dem Maschinenrechner (44) in Verbindung stehende berührungslos arbeitende Temperaturmeßvorrichtung mit einer Meßfläche zwischen der Preßstation (24, 26) und dem Tablettenabstreifer (38) angeordnet ist und die Meßzeit der Temperaturmeßvorrichtung so beschaffen ist, dass zumindest einige der Tabletten pro Umdrehung der Matrizenscheibe in ihrer Temperatur bestimmt werden können.Apparatus for monitoring the production of tablets in a rotary press, with die holes in a die plate for receiving a powder to be pressed, top and bottom punches, a printing station for pressing the powder in the die holes by means of top and bottom punches, a tablet scraper for stripping of the Stamping ejected tablets from the upper side of the die plate and a machine computer, characterized in that in the press room of the rotary press a non-contact temperature measuring device connected to the machine computer (44) with a measuring surface between the pressing station (24, 26) and the tablet scraper (38) is arranged and the measuring time of the temperature measuring device is such that at least some of the tablets per revolution of the die plate can be determined in their temperature. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, daß eine berührungslose Temperaturmeßvorrichtung vorgesehen ist, z.B. eine Infrarotmeßvorrichtung.Apparatus according to claim 1, characterized in that a non-contact temperature measuring device is provided, for example an infrared measuring device. Vorrichtung nach Anspruch 1 oder 2, dadurch gekennzeichnet, daß die Temperaturmeßvorrichtung über eine Leitung oder drahtlos mit dem Maschinenrechner (44) verbunden ist zwecks Protokollierung, Überwachung, Sortierung usw..Apparatus according to claim 1 or 2, characterized in that the temperature measuring device is connected via a line or wirelessly to the machine computer (44) for logging, monitoring, sorting, etc. Vorrichtung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, daß dem Maschinenrechner (44) ein mit dem Maschinenrechner (44) verbundener Positionsgeber (48) zugeordnet ist, der über den Maschinenrechner (44) entweder in Abhängigkeit von einer vom Positionsgeber (48) ermittelten Temperaturmeßposition der Matrizen (16) relativ zur Meßfläche einen Meßvorgang oder eine Auswertung eines Meßsignals im Maschinenrechner (44) auslöst.Device according to one of Claims 1 to 3, characterized in that associated with the machine computer (44) is a position transmitter (48) connected to the machine computer (44) and either via the machine computer (44) as a function of one of the position sensors (48). determined temperature measuring position of the matrices (16) relative to the measuring surface triggers a measuring operation or an evaluation of a measuring signal in the machine computer (44). Verfahren zur Überwachung der Produktion von Tabletten in einer Rundläuferpresse, die in einem Preßraum einen Rotor mit Ober- und Unterstempeln, Matrizenscheibe, Kurvensystem für die Stempel, mindestens eine Druckstation und ein Füllsystem für das pulverförmige Preßmaterial aufweist, dadurch gekennzeichnet, daß mit Hilfe eines berührungslos arbeitenden Temperatursensors mit einer kurzen Temperaturerfassungszeit im Preßraum die Temperatur der Tabletten gemessen wird, nachdem die Oberstempel die Matrize verlassen haben, wobei mindestens für einige der Tabletten pro Umdrehung des Rotors die Temperatur gemessen werden, mit Hilfe eines Positionsgebers Positionssignale für die Matrize erzeugt werden zur Bestimmung einer Temperaturmeßposition, die Temperaturdaten zur Temperaturmeßposition in Beziehung gesetzt werden und mittels einer Abkühlcharakteristik der Tabletten, dem Zeitpunkt der Temperaturmessung und dem Zeitpunkt der Pressung die maximale Temperatur der Tabletten bestimmt wird.A process for monitoring the production of tablets in a rotary press, having in a baling chamber a rotor with upper and lower punches, die plate, curve system for the punches, at least one printing station and a filling system for the powdered molding material, characterized in that by means of a non-contact working temperature sensor with a short temperature detection time in the baling chamber, the temperature of the tablets is measured after the punches have left the die, wherein at least some of the tablets per revolution of the rotor, the temperature are measured, are generated with the aid of a position sensor position signals for the die for determination a temperature measuring position, the temperature data are related to the temperature measuring position and by means of a cooling characteristic of the tablets, the time of temperature measurement and the time of pressing the maximum temperature of the tablets best becomes immt. Verfahren nach Anspruch 5, dadurch gekennzeichnet, daß pro Tablette mindestens zwei Temperaturmessungen vorgenommen werden.A method according to claim 5, characterized in that at least two temperature measurements are made per tablet. Verfahren nach Anspruch 5 oder 6, dadurch gekennzeichnet, daß mit Hilfe der Masse der Preßlinge und eines Zeit-Temperatur-Diagramms für das Material der Tabletten die von den Tabletten aufgenommene Energiemenge bestimmt wird.A method according to claim 5 or 6, characterized in that the amount of energy taken up by the tablets is determined with the aid of the mass of the compacts and a time-temperature diagram for the material of the tablets.
EP06026851A 2006-01-18 2006-12-23 Rotary tablet press and method for monitoring the production of tablets in a rotary tablet press Not-in-force EP1810819B1 (en)

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CN112763064B (en) * 2020-12-23 2022-11-25 浙江溯源光科技有限公司 Integrated spectrometer based on MEMS
CN113910668A (en) * 2021-10-04 2022-01-11 丽申药业股份有限公司 Method for preparing compound enzyme tablets

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