EP1778206A4 - Petits inhibiteurs moleculaires de membres de la famille des anti-apoptose bcl-2, et utilisations correspondantes - Google Patents

Petits inhibiteurs moleculaires de membres de la famille des anti-apoptose bcl-2, et utilisations correspondantes

Info

Publication number
EP1778206A4
EP1778206A4 EP05806407A EP05806407A EP1778206A4 EP 1778206 A4 EP1778206 A4 EP 1778206A4 EP 05806407 A EP05806407 A EP 05806407A EP 05806407 A EP05806407 A EP 05806407A EP 1778206 A4 EP1778206 A4 EP 1778206A4
Authority
EP
European Patent Office
Prior art keywords
small molecule
family members
molecule inhibitors
apoptotic bcl
bcl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05806407A
Other languages
German (de)
English (en)
Other versions
EP1778206A2 (fr
Inventor
Shaomeng Wang
Guoping Wang
Guozhi Tang
Renxiao Wang
Zaneta Nikolovska-Coleska
Dajon Wang
Liang Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
University of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan filed Critical University of Michigan
Priority claimed from PCT/US2005/029634 external-priority patent/WO2006023778A2/fr
Publication of EP1778206A2 publication Critical patent/EP1778206A2/fr
Publication of EP1778206A4 publication Critical patent/EP1778206A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP05806407A 2004-08-20 2005-08-22 Petits inhibiteurs moleculaires de membres de la famille des anti-apoptose bcl-2, et utilisations correspondantes Withdrawn EP1778206A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60341104P 2004-08-20 2004-08-20
PCT/US2005/029634 WO2006023778A2 (fr) 2004-08-20 2005-08-22 Petits inhibiteurs moleculaires de membres de la famille des anti-apoptose bcl-2, et utilisations correspondantes

Publications (2)

Publication Number Publication Date
EP1778206A2 EP1778206A2 (fr) 2007-05-02
EP1778206A4 true EP1778206A4 (fr) 2009-08-05

Family

ID=37897167

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05806407A Withdrawn EP1778206A4 (fr) 2004-08-20 2005-08-22 Petits inhibiteurs moleculaires de membres de la famille des anti-apoptose bcl-2, et utilisations correspondantes

Country Status (4)

Country Link
EP (1) EP1778206A4 (fr)
CN (1) CN101039662A (fr)
MX (1) MX2007002104A (fr)
ZA (1) ZA200702257B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE029289T2 (en) * 2008-12-05 2017-02-28 Abbvie Inc Sulfonamide derivatives as Bcl-2 selective apoptosis inducers for the treatment of cancer and immune diseases
BR112012005343A2 (pt) * 2009-09-10 2016-03-22 Novartis Ag sulfonamidas como inibidores de proteínas da família bcl-2 para o tratamento de câncer
CN103562202B (zh) * 2011-01-25 2016-09-14 密执安大学评议会 Bcl-2/bcl-xl抑制剂和使用它们的治疗方法
BR112014015308A8 (pt) * 2011-12-23 2017-06-13 Novartis Ag compostos para inibição da interação de bcl2 com contrapartes de ligação
MX2014007725A (es) * 2011-12-23 2015-01-12 Novartis Ag Compuestos para inhibir la interaccion de bcl2 con los componentes de enlace.
BR112014015322A8 (pt) * 2011-12-23 2017-06-13 Novartis Ag compostos e composições para inibir a interação de bcl2 com parceiros de ligação
FR3008976A1 (fr) * 2013-07-23 2015-01-30 Servier Lab "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
FR3008977A1 (fr) * 2013-07-23 2015-01-30 Servier Lab Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2018187894A1 (fr) * 2017-04-10 2018-10-18 师健友 Médicament pour le traitement de maladies tumorales, et ayant des effets antibactériens, antiviraux et anti-inflammatoires
CN109776414B (zh) * 2019-01-02 2022-04-22 山东大学 一种Bcl-2蛋白抑制剂及其制备方法和应用
CN111393366B (zh) * 2020-06-05 2020-09-01 北京华氏开元医药科技有限公司 四氢异喹啉类衍生物、制备方法、药物组合物及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2686123A (en) * 1951-07-19 1954-08-10 Us Agriculture Stabilization of dehydrated vegetable material
US6114397A (en) * 1990-07-12 2000-09-05 The United States Of America As Represented By The Department Of Health And Human Services Gossypol for the treatment of cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2686123A (en) * 1951-07-19 1954-08-10 Us Agriculture Stabilization of dehydrated vegetable material
US6114397A (en) * 1990-07-12 2000-09-05 The United States Of America As Represented By The Department Of Health And Human Services Gossypol for the treatment of cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AMOLAK CHAND JAIN ET AL: "SYNTHESIS OF SOME NATURALLY OCCURRING ACETYLCHROMENES", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 52, no. 4, 1 January 1979 (1979-01-01), pages 1203/1204, XP001068520, ISSN: 0009-2673 *
G. SCHILL, E. LOGEMANN: "4,6-Di-n-alkylpyrogallol-trimethyläther. Modellreaktionen zu gezielten Catenan-Synthesen", CHEMISCHE BERICHTE, vol. 106, 1973, pages 2910 - 2917, XP002533464 *
M. C. SUTTER: "The pharmacology of isolated veins", BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, vol. 24, no. 3, 1965, pages 742 - 751, XP009118730 *

Also Published As

Publication number Publication date
MX2007002104A (es) 2007-10-10
EP1778206A2 (fr) 2007-05-02
CN101039662A (zh) 2007-09-19
ZA200702257B (en) 2009-06-24

Similar Documents

Publication Publication Date Title
ZA200702257B (en) Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof
EP1856083A4 (fr) Inhibiteurs de chromen-4-one des elements anti-apoptotiques de la famille bcl-2 et utilisations
IL257622B (en) Methods and preparations for the treatment of persistent infections
EP1853242A4 (fr) Petites molecules inhibitrices du stat3 et leurs utilisations
IL225206A (en) A derivative of multinuclear carbamoylpyridone, its pharmaceutical composition and its use
HK1120160A1 (en) Trenched-gate field effect transistors and methods of forming the same
PL1894567T3 (pl) Środki farmaceutyczne do podawania skojarzonego oraz ich zastosowanie
IL217315A0 (en) Tetracycline derivatives and compositions comprising the same
IL178297A0 (en) Hydrazide derivatives and pharmaceutical compositions containing the same
HK1085643A1 (en) Uses and compositions for administration of capsaicin
IL183102A0 (en) Betulin derivatives and pharmaceutical compositions containing the same
EP2063887A4 (fr) Nouvelles petites molécules inhibitrices de mdm2 et leurs utilisations
PT2343320T (pt) Anticorpos anti-gitr e as suas utilizações
IL186400A0 (en) Compositions and methods for the inhibition of dishevelled proteins
IL192631A (en) A drug containing an isolated antibody or a functional portion thereof, pharmaceutical preparations and a kit containing it
EP1861387A4 (fr) Nouveaux derives benzoimidazole et composition pharmaceutique les contenant
EP1890677A4 (fr) Compositions pharmaceutiques et leur utilisation
IL189782A (en) The history of sulfonylpyrol and its medicinal products and their use
ATE413105T1 (de) Eiskonfekt und haltemittel
EP1968649A4 (fr) Nanoparticules de proteines et leur utilisation
IL177744A0 (en) Aptamers and pharmaceutical compositions containing the same
ZA200704295B (en) Arthrospira-based compositions and uses thereof
EP1906990A4 (fr) Agent anticoagulant et son utilisation
GB0516069D0 (en) Pharmaceutical and use thereof
EP1858535A4 (fr) Compositions a base d'actinidia et modes d'utilisation

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20070301

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK YU

RIN1 Information on inventor provided before grant (corrected)

Inventor name: XU, LIANG

Inventor name: WANG, DAJON

Inventor name: NIKOLOVSKA-COLESKA, ZANETA

Inventor name: WANG, RENXIAO

Inventor name: TANG, GUOZHI

Inventor name: WANG, GUOPING

Inventor name: WANG, SHAOMENG

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1106438

Country of ref document: HK

A4 Supplementary search report drawn up and despatched

Effective date: 20090708

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20091007

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1106438

Country of ref document: HK