ZA200702257B - Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof - Google Patents

Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof

Info

Publication number
ZA200702257B
ZA200702257B ZA200702257A ZA200702257A ZA200702257B ZA 200702257 B ZA200702257 B ZA 200702257B ZA 200702257 A ZA200702257 A ZA 200702257A ZA 200702257 A ZA200702257 A ZA 200702257A ZA 200702257 B ZA200702257 B ZA 200702257B
Authority
ZA
South Africa
Prior art keywords
small molecule
family members
molecule inhibitors
apoptotic bcl
bcl
Prior art date
Application number
ZA200702257A
Inventor
Wang Shaomeng
Wang Guoping
Tang Guozhi
Wang Renxiao
Nikolovska-Coleska Zaneta
Yang Dajun
Xu Liang
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Publication of ZA200702257B publication Critical patent/ZA200702257B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200702257A 2004-08-20 2005-08-22 Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof ZA200702257B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60341104P 2004-08-20 2004-08-20

Publications (1)

Publication Number Publication Date
ZA200702257B true ZA200702257B (en) 2009-06-24

Family

ID=37897167

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200702257A ZA200702257B (en) 2004-08-20 2005-08-22 Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof

Country Status (4)

Country Link
EP (1) EP1778206A4 (en)
CN (1) CN101039662A (en)
MX (1) MX2007002104A (en)
ZA (1) ZA200702257B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE029289T2 (en) * 2008-12-05 2017-02-28 Abbvie Inc Sulfonamide derivatives as bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
AU2010294292B2 (en) * 2009-09-10 2013-07-18 Novartis Ag Sulfonamides as inhibitors of Bcl-2 family proteins for the treatment of cancer
EP2668180B1 (en) * 2011-01-25 2018-08-01 The Regents of The University of Michigan Bcl-2/bcl-xl inhibitors for use in the treatment of cancer
JP2015503516A (en) * 2011-12-23 2015-02-02 ノバルティス アーゲー Compound for inhibiting interaction between BCL2 and binding partner
MX2014007732A (en) * 2011-12-23 2015-01-12 Novartis Ag Compounds for inhibiting the interaction of bcl2 with binding partners.
MX2014007730A (en) * 2011-12-23 2015-01-12 Novartis Ag Compounds for inhibiting the interaction of bcl2 with binding partners.
FR3008976A1 (en) * 2013-07-23 2015-01-30 Servier Lab "NOVEL INDOLIZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM"
FR3008977A1 (en) * 2013-07-23 2015-01-30 Servier Lab NOVEL ISOINDOLINE OR ISOQUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
EP3669869B1 (en) * 2017-04-10 2023-11-22 Shi, Jianyou Drug for treating tumor diseases, and having antibacterial, antivirus and anti-inflammatory effects
CN109776414B (en) * 2019-01-02 2022-04-22 山东大学 Bcl-2 protein inhibitor and preparation method and application thereof
CN111393366B (en) * 2020-06-05 2020-09-01 北京华氏开元医药科技有限公司 Tetrahydroisoquinoline derivatives, preparation method, pharmaceutical composition and application

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2686123A (en) * 1951-07-19 1954-08-10 Us Agriculture Stabilization of dehydrated vegetable material
US5385936A (en) * 1990-07-12 1995-01-31 The United States Of America As Represented By The Secretary Of The Department Of The Health And Human Services Gossypol acetic acid for the treatment of cancer

Also Published As

Publication number Publication date
MX2007002104A (en) 2007-10-10
CN101039662A (en) 2007-09-19
EP1778206A4 (en) 2009-08-05
EP1778206A2 (en) 2007-05-02

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