EP1773349A4 - Methodes et compositions de traitement de la preeclampsie - Google Patents

Methodes et compositions de traitement de la preeclampsie

Info

Publication number
EP1773349A4
EP1773349A4 EP05779072A EP05779072A EP1773349A4 EP 1773349 A4 EP1773349 A4 EP 1773349A4 EP 05779072 A EP05779072 A EP 05779072A EP 05779072 A EP05779072 A EP 05779072A EP 1773349 A4 EP1773349 A4 EP 1773349A4
Authority
EP
European Patent Office
Prior art keywords
preeclampsia
compositions
treatment
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05779072A
Other languages
German (de)
English (en)
Other versions
EP1773349A2 (fr
Inventor
Judah Folkman
Raghu Kalluri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Medical Center Corp
Beth Israel Deaconess Medical Center Inc
Original Assignee
Childrens Medical Center Corp
Beth Israel Deaconess Medical Center Inc
Beth Israel Hospital Association
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center Corp, Beth Israel Deaconess Medical Center Inc, Beth Israel Hospital Association filed Critical Childrens Medical Center Corp
Publication of EP1773349A2 publication Critical patent/EP1773349A2/fr
Publication of EP1773349A4 publication Critical patent/EP1773349A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP05779072A 2004-05-04 2005-05-04 Methodes et compositions de traitement de la preeclampsie Withdrawn EP1773349A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56798104P 2004-05-04 2004-05-04
PCT/US2005/015511 WO2005110462A2 (fr) 2004-05-04 2005-05-04 Methodes et compositions de traitement de la preeclampsie

Publications (2)

Publication Number Publication Date
EP1773349A2 EP1773349A2 (fr) 2007-04-18
EP1773349A4 true EP1773349A4 (fr) 2009-07-29

Family

ID=35394672

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05779072A Withdrawn EP1773349A4 (fr) 2004-05-04 2005-05-04 Methodes et compositions de traitement de la preeclampsie

Country Status (6)

Country Link
US (1) US8273383B2 (fr)
EP (1) EP1773349A4 (fr)
JP (1) JP2007536251A (fr)
AU (1) AU2005244167A1 (fr)
CA (1) CA2563704A1 (fr)
WO (1) WO2005110462A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005244167A1 (en) 2004-05-04 2005-11-24 Beth Israel Deaconess Medical Center Methods and compositions for treatment of preeclampsia
WO2008103202A2 (fr) * 2006-11-21 2008-08-28 Beth Israel Deaconess Medical Center Protéines et gènes associés à l'hypoxie et permettant le diagnostic et le traitement des complications liées à la grossesse
US8348856B1 (en) 2008-12-16 2013-01-08 Zanetta Malanowska-Stega Simultaneous multiple method out-patient uterus biopsy device and method
KR101230740B1 (ko) 2010-09-08 2013-02-07 인제대학교 산학협력단 자간전증의 조기 진단 및 예후 평가 방법
JPWO2014104406A1 (ja) * 2012-12-27 2017-01-19 学校法人慶應義塾 骨粗鬆症治療剤及び治療剤のスクリーニング方法
CN103235142B (zh) * 2013-04-28 2015-04-15 成都中医药大学 一种孕妇初次妊娠筛查试剂盒
GB201504772D0 (en) 2015-03-20 2015-05-06 Univ Aston Preeclampsia
US11364020B2 (en) 2016-12-09 2022-06-21 Techmed Ventures, Llc Brush biopsy device, kit and method

Citations (2)

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Publication number Priority date Publication date Assignee Title
US5643900A (en) * 1993-07-02 1997-07-01 Fotsis; Theodore Method for treatment of pathological conditions associated with angiogenesis and preparation therefor
US20020147183A1 (en) * 2000-08-18 2002-10-10 Agoston Gregory E. Antiangiogenic agents

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DE2757157C3 (de) 1977-12-19 1980-10-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 16 a -alkylierten Steroiden
DK175069B1 (da) 1986-03-11 2004-05-24 Hoffmann La Roche Pyrocatecholderivater
US5198366A (en) 1986-03-23 1993-03-30 Technion Research & Development Foundation Ltd. Method for the detection of pregnancy disorders
YU213587A (en) 1986-11-28 1989-06-30 Orion Yhtymae Oy Process for obtaining new pharmacologic active cateholic derivatives
US5240848A (en) * 1988-11-21 1993-08-31 Monsanto Company Dna sequences encoding human vascular permeability factor having 189 amino acids
US5238819A (en) * 1988-12-14 1993-08-24 The Regents Of The University Of California Diagnostic assay for the detection of preeclampsia
US5332671A (en) * 1989-05-12 1994-07-26 Genetech, Inc. Production of vascular endothelial cell growth factor and DNA encoding same
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5219739A (en) * 1989-07-27 1993-06-15 Scios Nova Inc. DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121
CA2078804C (fr) * 1991-10-01 2003-02-25 Takehiko Suzuki Fabrication et utilisation de glycosides originaux de catechol oestrogene
JPH06157344A (ja) 1992-02-07 1994-06-03 Childrens Medical Center Corp:The 血管新生阻害のための医薬製剤及び血管新生阻害方法
US5712395A (en) * 1992-11-13 1998-01-27 Yissum Research Development Corp. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
US5763441A (en) * 1992-11-13 1998-06-09 Sugen, Inc. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
US5895783A (en) * 1993-07-16 1999-04-20 Schering Aktiengesellschaft Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor
US6410322B1 (en) * 1993-07-27 2002-06-25 Hybridon Inc Antisense oligonucleotide inhibition of vascular endothelial growth factor expression
US6908910B2 (en) 1993-08-06 2005-06-21 The Children's Medical Center Corporation Estrogenic compounds as anti-mitotic agents
US5504074A (en) * 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
US5861499A (en) * 1994-02-10 1999-01-19 Imclone Systems Incorporated Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain
US5543138A (en) * 1994-03-10 1996-08-06 Genetics Institute, Inc. Methods of diagnosing and treating preeclampsia
US6613757B1 (en) * 1994-09-22 2003-09-02 Board Of Regents, The University Of Texas System Combination of prostacyclin with an estrogen or progestin for the prevention and treatment of atherosclerotic vascular disease including preeclampsia and for the treatment of hypertension, and for hormone replacement therapy
GB9510481D0 (en) 1995-05-24 1995-07-19 Orion Yhtymae Oy New catechol derivatives
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US20030195180A1 (en) 1995-12-12 2003-10-16 D'amato Robert John Estrogenic compounds as anti-mitotic agents
US6100071A (en) * 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
US6399585B1 (en) * 1996-05-15 2002-06-04 Janet E. Larson In Utero treatment of CFTR-related deficiencies
WO1998028006A1 (fr) 1996-12-23 1998-07-02 Cambridge University Technical Services Limited Diagnostic et traitement de grossesses pathologiques
US20010056068A1 (en) * 1998-03-04 2001-12-27 Kristof Chwalisz Method of treatment and prevention of nitric oxide deficiency-related disorders with citrulline and citrulline derivatives
US6677300B1 (en) * 1998-09-09 2004-01-13 Scios, Inc. Treatment of microvascular angiopathies
EP1417971A3 (fr) 1998-09-09 2004-06-30 Scios Inc. Utilisation d' un facteur angiogénique pour le traitement d'angiopathies microvasculaires
US7030083B2 (en) * 1998-09-09 2006-04-18 University Of Washington Treatment of eclampsia and preeclampsia
US6245577B1 (en) * 1998-09-11 2001-06-12 Midland Bioproducts Corporation IgG antibody testing method
EP1016726A1 (fr) * 1998-12-30 2000-07-05 Introgene B.V. Thérapie génique pour la promotion de l' angiogenèse
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WO2002004678A2 (fr) 2000-07-07 2002-01-17 Genetics Institute, Llc. Diagnostic et traitement de la pré-éclampsie et des troubles trophoblastiques de la gestation et compositions à cet effet
US7135581B2 (en) * 2000-08-18 2006-11-14 Entremed, Inc. Antiangiogenic agents
GB0026823D0 (en) * 2000-11-02 2000-12-20 King S College London Diagnosis of pre-eclampsia
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WO2003015704A2 (fr) 2001-08-17 2003-02-27 University Of Pittsburgh Administration de metabolites de l'oestradiol pour le traitement ou la prevention de l'obesite, du syndrome metabolique, du diabete et de troubles vasculaires et renaux
US20030236439A1 (en) 2002-01-30 2003-12-25 Gregory Agoston Non-steroidal analogs of 2-methoxyestradiol
BRPI0312818B8 (pt) * 2002-07-19 2021-05-25 Beth Israel Deaconess Medical Ct Inc uso de uma medida do nível do polipeptídeo sflt-1 em uma amostra de uma paciente e uso de uma medida dos níveis de pelo menos dois dos peptídeos sflt1, vegf livre ou polipeptídio pigf livre em uma amostra de um paciente usando um métrico
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Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US5643900A (en) * 1993-07-02 1997-07-01 Fotsis; Theodore Method for treatment of pathological conditions associated with angiogenesis and preparation therefor
US20020147183A1 (en) * 2000-08-18 2002-10-10 Agoston Gregory E. Antiangiogenic agents

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
ACIEN P ET AL: "Perinatal morbidity and mortality in pregnancy hypertensive disorders: prognostic value of the clinical and laboratory findings", INTERNATIONAL JOURNAL OF GYNECOLOGY AND OBSTETRICS, NEW YORK, NY, US, vol. 32, no. 3, 1 July 1990 (1990-07-01), pages 229 - 235, XP023149313, ISSN: 0020-7292, [retrieved on 19900701] *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; August 1992 (1992-08-01), BHANSALI K G ET AL: "Quantitative determination of 17 beta-estradiol and progesterone in cellular fractions of term placentae of normal and hypertensive patients.", XP002531982, Database accession no. NLM1439187 *
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MIZUTANI S ET AL: "Positive effect of estradiol and progesterone in severe pre- eclampsia", EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY, LEIPZIG, DE, vol. 92, no. 2, 1 December 1988 (1988-12-01), pages 161 - 170, XP002094117, ISSN: 0232-7384 *
MOOBERRY SUSAN L: "Mechanism of action of 2-methoxyestradiol: new developments.", DRUG RESISTANCE UPDATES : REVIEWS AND COMMENTARIES IN ANTIMICROBIAL AND ANTICANCER CHEMOTHERAPY DEC 2003, vol. 6, no. 6, December 2003 (2003-12-01), pages 355 - 361, XP002531883, ISSN: 1368-7646 *
NADAR S ET AL: "Plasma markers of angiogenesis in pregnancy induced hypertension", AMERICAN JOURNAL OF HYPERTENSION, ELSEVIER, vol. 17, no. 5, 1 May 2004 (2004-05-01), pages S161 - S162, XP004575831, ISSN: 0895-7061 *
RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY AUG 1992, vol. 77, no. 2, August 1992 (1992-08-01), pages 161 - 169, ISSN: 0034-5164 *
See also references of WO2005110462A2 *
SVEDAS EIMANTAS ET AL: "Endothelial dysfunction in uterine circulation in preeclampsia: Can estrogens improve it?", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 187, no. 6, December 2002 (2002-12-01), pages 1608 - 1616, XP009117836, ISSN: 0002-9378 *
YAKUGAKU ZASSHI : JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN JUN 2003, vol. 123, no. 6, June 2003 (2003-06-01), pages 399 - 411, ISSN: 0031-6903 *
ZEISLER HARALD ET AL: "Concentrations of estrogens in patients with preeclampsia", WIENER KLINISCHE WOCHENSCHRIFT, vol. 114, no. 12, 28 June 2002 (2002-06-28), pages 458 - 461, XP009118132, ISSN: 0043-5325 *

Also Published As

Publication number Publication date
JP2007536251A (ja) 2007-12-13
WO2005110462A3 (fr) 2006-07-06
AU2005244167A1 (en) 2005-11-24
CA2563704A1 (fr) 2005-11-24
US20080160105A1 (en) 2008-07-03
WO2005110462A2 (fr) 2005-11-24
US8273383B2 (en) 2012-09-25
EP1773349A2 (fr) 2007-04-18

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