EP1773328A1 - Prebiotic intimate personal hygiene product - Google Patents

Abstract

The invention relates to active substances and active ingredient substances that are prebiotically active in the intimate region and/or gastrointestinal region.

Description

 Prebiotic Intimate Care

The present invention relates to active substances or combinations of active substances which are prebiotically active in the genital area and / or the gastrointestinal area.

The cosmetic treatment of the vaginal region is always associated with an influence on the vaginal flora. The use of surfactant products may weaken the bacterial flora of lactobacilli and bifidobacteria to such an extent that they can no longer perform their natural protective function. The result may be vaginal infections, especially with the yeast Candida albicans.

Probiotic products (eg vaginal suppositories with beneficial bacteria, the so-called "Döderlein-Flora") have to be purchased in the pharmacy, are cumbersome to use and are therefore not accepted by most consumers, and probiotic products are only aimed at multiplying the beneficial germs However, to have an effect, these bacteria must actively displace the pathogenic microorganisms, which may not always be guaranteed by the use of probiotic products.

The object of the present invention was therefore to provide a gentle, advantageously easier-to-handle alternative to the intimate care products described in the prior art.

This problem is solved by active ingredients or combinations of active ingredients that are prebiotically active in the vaginal region. The application of the prebiotic active ingredients can be carried out in the context of daily body cleansing.

Under the prebiotic effect according to the invention is to be understood that the growth and / or physiological activity of the desired, especially skin-friendly, skin germs or microflora - in this case, the Lactobacilli and / or Bifidobacteria - against the growth and / or the physiological activity of the undesirable, especially skin-hostile, skin germs or microflora - in this case so the pathogenic form of Candida - is promoted. This can be achieved either by using an active substance or a combination of active substances which promotes the growth of the lactobacilli and / or bifidobacteria without directly influencing the pathogenic hyphal form of Candida, and also by the fact that the active substance resp The combination of active ingredients reduces the presence of the unwanted form of Candida, without directly affecting the growth of lactobacilli and / or bifidobacteria. In a particularly preferred and particularly surprising embodiment of the invention, however, the active ingredient or combination of active substances promotes the growth of the desired skin germs and at the same time reduces the presence of the unwanted hyphae form of Candida.

The combination of active substances is a combination of (a) an active ingredient which causes a reduction in the adhesion of candida, and (b) an active ingredient which promotes the growth of lactobacilli and / or bifidobacteria.

The use of this drug combination causes firstly a promotion of Laktobazillen- and Bifidobakterienflora and thus a regeneration of the protective vaginal bacteria. Secondly, the reduction of Candida adhesion to vaginal epithelial cells additionally supports the establishment of lactobacilli and bifidobacteria. On the other hand, since an increased occurrence of protective bacteria represses the growth of Candida, the combination of the two active ingredients can produce a true synergistic effect.

According to the invention, it has surprisingly been possible to show that the use of active substances which cause a reduction of the Candida adhesion does not affect the growth of the Lactobacilli. The active ingredient combination according to the invention is also applicable in the intestinal area, except in the vaginal area. For here, too, lactobacilli and bifidobacteria occur naturally and, where appropriate, an unwanted and optionally pathogenic change in the microflora may occur due to a strong increase of Candida, which is treated by the combination of active substances according to the invention or which can be prevented by the combination of active substances according to the invention.

Substances that cause a reduction in Candida adhesion

The substances which cause a reduction of the Candida adhesion can be selected in particular from the group consisting of: a) substances which directly reduce the adhesion itself, ie are anti-adhesively effective, b) substances which reduce the hyphen formation of Candida and thereby indirectly reduce the Candida adhesion by keeping Candida in an apathogenic, non-adhesive form and preventing or at least reducing the transition to the pathogenic form, c) substances which have a toxic or antimycotic effect on Candida and thereby indirectly Reduce Candida adhesion by decreasing the amount and / or vitality of Candida.

According to a particular embodiment, the substances which reduce the hyphenation of Candida and / or are anti-adhesively active, selected from Dufstoffalkoholen, propolis extracts, plant extracts and / or terpenes and derivatives thereof.

For the purposes of the present invention, the term "perfume alcohols" is understood as meaning fragrances which have one or more, preferably one or two, hydroxyl groups which are esterifiable or esterified, regardless of how the molecule is developed further. Salicylic acid esters can also be used as perfume alcohols. Suitable are all combinations of geometric isomers. It is also possible esters These compounds, for example, anethole (1-methoxy-4- (1-propenylbenzene) or linalyl acetate.

Fragrance alcohols having one or two free hydroxyl groups are particularly preferably used. From the large group of perfume alcohols, which include the terpene alcohols (which are described in more detail below), can be mentioned preferred representatives having at least one free hydroxyl group, so that in the present invention are preferred: 10-undecen-1-ol , 2,6-dimethylheptan-2-ol, 2-methylbutanol, 2-methylpentanol, 2-phenylpropanol, 2-tert-butycyclohexanol, 3,5,5-

Trimethylcyclohexanol, 3-hexanol, 3-methyl-5-phenylpentanol, 3-octanol, 3-phenylpropanol, 4-heptenol, 4-isopropylcyclohexanol, 4-tert-butycyclohexanol, 6,8-dimethyl-2-nonanol, 6-nonenoyl 1-ol, 9-decene-1-ol, alpha-methylbenzyl alcohol, 1-hydroxy-4- (1-propenylbenzene), amyl salicylate, benzyl alcohol, benzyl salicylate, butyl salicylate, citronellols, cyclohexyl salicylate, decanol, dihydromyrcenol, dimethylbenzylcarbinol, dimethylheptanol, dimethyloctanol, Ethyl salicylate, ethylvanilin, eugenol, heptanol, hexyl salicylate, isoeugenol, isopulegol, menthol, myrtenol, n-hexanol, nerol, nonanol, octanol, para-menthane-7-ol, phenylethyl alcohol, phenyl salicylate, tetrahydrogeraniol, tetrahydrolinalool, thymol, trans-2- cis-6-nonadicnol, trans-2-nonen-1-ol, trans-2-octenol, undecanol, cinnamyl alcohol. Preferred are, for example, eugenol and its derivatives, 1-hydroxy-4- (1-propenylbenzene), isoeugenol, citronellols, menthol.

According to the invention, terpenes are to be understood as meaning all natural substances and derivatives made up of isoprene units. For example, Famesol, Patchoulialkohol, squalene, geraniol are preferred.

According to the invention, according to a particular embodiment, terpenes are to be understood as meaning in particular the mono-, sesqui- and / or diterpenes. It is possible to use acyclic, monocyclic and / or bicyclic as well as higher cyclic mono-, sesqui- and / or diterpenes. Examples of derivatives of monoterpenes, sesquiterpenes or diterpenes are alcohols, such as, for example, farnesol and their ethers, acids, such as, for example, famesolic acid, and their mono-, sesqui- and diterpenes bearing their esters and other functional groups. Suitable are all combinations of geometric isomers. Also included are α-famers (3,7,11-trimethyl-1,3,6,10-dodecatetraene) and β-famesen (7,11-dimethyl-3-methylene-1,6,10,10-dodecatriene) and nerolidol (3,7,11-trimethyl-1, 6,10-dodecatriene-3-ol) as well as patchouli alcohol, bisabolene, sesquiphellandrene, zingiberene, cadins, caryophyllene (especially α-caryophyllene (humulene) and β-caryophyllene), aryl-tumerone , Tumerone, xanthorrhizole, vulgaris and beta-selenin. Examples of monoterpenes are α- or β-ocimene, linalool, linalyl acetate, borneols, isoborneols, carenees, terpineols, p-menthadienes, limonene, nerol, nerolic acid, geraniol, geranic acid, α- or β-phellandrene and / or thujone. especially geraniol, linalool and / or thujone are preferred. Geranylgeraniol (3,7,11,15-tetramethyl-2,6,10,14-hexadecetetraene-1-ol) as well as its isomers and derivatives may be mentioned here as an example of the diterpenes.

Plant extracts which contain perfume alcohols and / or terpenes, in particular mono-, sesqui- and / or diterpenes, for example geranium oil, rose oil, patchouli oil, pine needle oil, orange oil, orange blossom oil, lavender oil, lime oil, jasmine oil, peppermint oil, basil oil, may likewise preferably be used. Citronella oil, cypress oil, cedar leaf oil, cedarwood oil, coriander oil, rosewood oil, thyme oil, allspice oil, ginger oil or clove oil, in particular patchouli oil, clove oil, cypress oil, cedarwood oil and / or aniseed oil.

According to a preferred embodiment, the mono-, sesqui- and / or diterpenes are selected from geraniol, citronell oil, farnesol and patchouli alcohol. These substances show a particularly good inhibiting effect on the asexual propagation of fungi, so that a particularly good action without fungistatic or fungicidal effects can be observed with low use of active ingredient.

According to another preferred embodiment, the terpenes are selected from terpene alcohols, ie such terpenes, preferably mono-, sesqui- and / or diterpenes bearing a free hydroxyl group. Citronellols, geraniol, farnesol and patchouli alcohol are particularly preferred.

According to another preferred embodiment, the perfume alcohols are selected from eugenol, cinnamyl alcohol and anethole, in particular eugenol.

According to a particularly preferred embodiment, the substances which reduce the hyphenation of Candida are selected from tea tree oil, algae extracts, propolis extracts, fucoidin, farnesol, farnesolic acid or other substances which influence the morphogenesis of fungi.

Fucoidin, also known as fucosidan or fucoidan, is a polysaccharide of brown algae (Fucus vesiculosus, bladderwrack) consisting mainly of sulfated L-fucose in 1,2-α-glycosidic linkage. Advantageously, it has been found that the hyphal formation of Candida albicans is significantly reduced while at the same time not affecting cell growth.

Propolis is a resinous mass with a melting point between about 50 and 70 ⁰ C, which is collected by bees and is used in the hive as a coating of the walls and for securing the honeycomb. It is also known as stuffing wax, bee glue or bee resin.

Furthermore, carrier-bound forms of the aforementioned Dufstoffalkohole and / or terpenes or derivatives thereof can be used according to the invention. Carrier-bound forms of the perfume alcohols and / or terpenes are to be understood according to the invention as those forms of the compounds which enable the gradual release of the perfume alcohols and / or terpenes. This can be done in particular via a self-adjusting equilibrium between bound and free form of the terpenes and / or perfume alcohols or via bond cleavage, in particular hydrolysis of covalent bonds. In a preferred embodiment, the carrier-bound form is a silicic acid ester of the fragrance alcohols and / or terpenes.

The preparation of the silicic acid esters succeeds in particular by simple transesterification of silicic acid esters (n = 1) or oligosilicic esters (n> 1) of lower alcohols with perfume and / or terpene alcohols, it being possible to use both individual perfume and / or terpene alcohols and mixtures thereof , Depending on the reaction time and conditions, the lower alcohols are split off and the fragrance or terpene alcohols are bound, the alcohols being exchanged more easily along the Si-O-Si chain than the terminal alcohols.

Silica esters according to one of the formulas (I) or (II) and / or mixtures thereof are particularly preferably used according to the invention.

O-R

R- [O-Si-] _n -OR (I)

O-R

and

wherein at least one R is selected from the group formed from terpene alcohol radicals and perfume alcohol radicals, and all other Rs are independently selected from the group consisting of H, the straight-chain or branched, saturated or unsaturated, substituted or unsubstituted C _1-6 hydrocarbon radicals Terpene alcohol residues containing perfume alcohol residues and polymers, and m has values from the range 1 to 20 and n assumes values from the range 1 to 100.

The carrier-bound form in another preferred embodiment according to the invention is esters of perfume alcohols and / or terpenes with polymers.

Such substances are particularly preferably carried out by reaction of the terpene alcohols and / or perfume alcohols with polymers which carry functional groups which are selected, in particular, from acid groups, acid chloride groups, ester groups, primary, secondary and tertiary amide groups.

According to the invention, polyacrylic acid, polyacrylic acid esters, polymethacrylic acid, polymethacrylic acid esters,

Polycarboxylic acids, (in particular carboxymethylcellulose) and copolymers of the underlying monomer (also with monomers other than those mentioned) and primary, secondary or tertiary polyacrylamides used. In particular, chain lengths of about 2000 to 300,000 g / mol are preferred.

In the carrier-bound form of the perfume alcohols and / or terpenes, another preferred embodiment according to the invention involves cage molecules which are loaded with Dufstoffalkoholen and / or terpenes.

In the context of the invention, cage molecules are in particular those organic macrocyclic molecules which have a cage-like, spatial structure and are capable of acting as so-called host molecules to include one or more so-called guest molecules. Preferably, only one guest molecule is included at a time.

Examples of organic cage molecules that can be used according to the invention include cucurbiturils, calixarenes, calixresorcarenes, cyclodextrins, cyclophanes, crown ethers, fullerenes, cryptophanes, carcerands, hemicarcerands, cyclotriveratrylenes, spherands and cryptands.

According to a particularly preferred embodiment, substances which reduce candida adhesion use substances which reduce the hyphae formation of candida, their concentration being chosen such that they do not act fungicidal (fungicidal) or fungistatic (fungus growth-inhibiting) at the point of application , A particular advantage of this embodiment is that the risk of resistance to the substances used is relatively low, since the fungi are neither killed nor their growth inhibited. For example, it is known that propolis extracts have Candida albicans minimum inhibitory concentrations (the lowest concentration of the substance preventing proliferation of the fungus) of 0.12% by weight and greater (Hegazi, Z. Naturforsch. 55c, 70-75 ( 2000)). These minimum inhibitory concentrations can be readily determined in a manner known to those skilled in the art.

The antimycotic active substances which can be used according to the invention are preferably those which are already customarily used for the treatment of fungal infestation, in particular in the case of candidoses. These may in particular be antifungals of the polyene type, in particular nystatin, amphotericin B or natamycin, and / or antifungals of the azole type, in particular miconazole, clotrimazole or ketoconazole. In a particularly preferred embodiment according to the invention, the antimycotic substance is climbazole, octopirox or mixtures thereof. The substances which cause a reduction in the Candida adhesion, are preferably in concentrations of 0.00001 - 1 wt .-%, preferably from 0.0001 - 0.1 wt .-%, in particular from 0.001 to 0.01 wt. -% used. Substances that are conducive to the proliferation of lactobacilli and / or bifidobacteria

In the substances which promote the proliferation of lactobacilli and / or bifidobacteria, in a preferred embodiment they are an oligosugar or a derivative thereof and / or plant extracts, in particular those which contain oligosugars or a derivative thereof.

In a preferred embodiment, the oligo sugar is one which comprises fructose and / or glucose units, the glucose fraction preferably being up to 10%, in particular up to 5%, especially between 2 and 3% , and wherein the oligosugar is preferably constructed substantially linear. The number of sugar units is preferably between 5 and 150, in particular between 10 and 100. The molecular weight of the oligo sugar is preferably between 1000 and 15000 g / mol, in particular between 2000 and 8000 g / mol, especially between 4000 and 6000 g / mol. The sugar units are preferably in furanosider form and are preferably linked together by ß (2-1) bond. The sugar units can also be derivatized or modified according to the invention, in particular by alkoxylation and / or alkylation, as described, for example, in WO 02/00188.

In a particularly preferred embodiment, the oligosugar is inulin or a derivative thereof and the plant extract containing the oligosugar is an inulin-containing plant extract, in particular selected from extracts of dahlia tubers, artichokes, Jerusalem artichoke tubers, chicory roots (Cichorium intybus), dandelion roots and from extracts of daisy family (Asteraceae), in particular Inula, or mixtures thereof. With regard to the usable derivatives of inulin, reference is explicitly made to the disclosure of WO 02/00188. Further plant extracts suitable according to the invention are tea extracts, in particular from the family of the Theaceae or from the family of the Malvaceae, as well as extracts from the family of the Vitaceae.

The extract of the family of Theaceae is preferably an extract of Camellia spec, especially an extract of white tea {Camellia sinensis). In a preferred embodiment, this is an extract from the leaves, as obtainable, for example, from Cosmetochem (Germany).

The extract from the Malvaceae family is preferably an extract of Hibiscus spec, in particular an extract of Sudanese tea (Karkade, Hibiscus, Hibiscus sabdariffa).

The extract of the Vitaceae family is preferably an extract of Vitis spec, in particular an extract of the grape (Vitis viticola). This is particularly preferably an extract of grape seeds.

The substances which promote the proliferation of lactobacilli and / or bifidobacteria are preferably used in concentrations of 0.01-10% by weight, more preferably in concentrations of 0.05-5.0% by weight, in particular in Concentrations of 0.2-2.5 wt .-% used.

Fungi whose adhesion is diminished

The use according to the invention particularly preferably reduces the adhesion of the medically relevant forms of Candida, for example C. albicans, C. boidinii, C. catenulata, C. ciferii, C. dubliniensis, C. glabrata, C. guilliermondii, C. haemulonii, C. kefyr, C. krusei, C. lipolytica, C. lusitaniae, C. norvegensis, C. parapsilosis, C. pulcherrima, C. rugosa, C. tropicalis, C. utilis, C. viswanathii. Particularly preferred according to the invention are C. albicans, C. stellatoidea, C. tropicalis, C. glabrata and C. parapsilosis. Pharmaceutical or cosmetic preparation and foodstuffs For the preparation of pharmaceutical or cosmetic preparations and for the production of a food, the active ingredients, optionally in combination with other active substances, together with one or more inert conventional carriers and / or diluents, for. As with gelatin, gum arabic, corn starch, lactose, cane sugar, sorbitol, microcrystalline cellulose, magnesium stearate, polyvinylpyrrolidone, citric acid, tartaric acid, water, benzyl alcohol, polyalkylene glycol, water / ethanol, water / glycerol, water / sorbitol, water / polyethylene glycol, propylene glycol , Titanium dioxide, a cellulose derivative such as carboxymethylcellulose or fatty substances such as hard fat, talc or vegetable oils or their suitable mixtures in conventional pharmaceutical preparations such as tablets, dragees, capsules, powders, suspensions, drops, ampoules, juices or suppositories. Optionally, preservatives, stabilizers, wetting agents, emulsifiers or salts for altering the osmotic pressure, lactic acid or buffers may also be present. Surfactants such as salts of bile acids or animal or plant phospholipids, but also mixtures thereof and liposomes or components thereof can also be used as carriers.

Skin treatment agents

In a particularly preferred embodiment according to the invention, the pharmaceutical or cosmetic preparations are those for topical application to the skin and its appendages and / or for application to the mucous membrane, in particular in the vaginal and / or intestinal region. In the following, these preparations are also called skin treatment agents. The pH of the preparation is preferably between pH 5 and 7, more preferably between pH 5 and 6.

The cosmetic or pharmaceutical composition according to the invention may be any dosage form, for example a solid or liquid soap, a lotion, a powder, a spray, an aerosol, a foam, a tincture, a stick preparation, a cream, a gel , one Emulsion, a cleaning fluid or cleansing milk, a deodorant, an antiperspirant, an ointment, a hair conditioner or a shampoo and it may also be contained in any of the described or other dosage forms, for example in a plaster, in particular in a gel reservoir or matrix patch ,

As applicators, for example, depending on the application form, for example, pen barrel, roll-on, pump, tube, crucible, dispenser, cloth, aerosol can or bottle can be used.

In particular, the skin or mucous membrane in the vaginal area and in the testinal area can be considered as the site of application. Basically, all physical areas that are naturally populated by lactobacilli and bifidobacteria and in which there is a risk of unwanted colonization by Candida come into question.

The cosmetic or pharmaceutical composition according to the invention may also contain further constituents than those mentioned above. In a preferred embodiment, it contains at least one of the substances listed below. It may also contain any combination of the ingredients listed below.

In one embodiment according to the invention, the composition contains, in addition to at least one plant extract to be used according to the invention in a prebiotic active ingredient combination, at least one further plant extract. This further plant extract can be prepared, for example, by extraction of the entire plant, but also exclusively by extraction from flowers and / or leaves and / or seeds and / or other parts of plants. According to the invention, especially the extracts from the meristem, so the divisible educated tissue of the plants, and the extracts of special plants such as green tea, witch hazel, chamomile, pansy, Paeonie, aloe vera, horse chestnut, sage, willow bark, cinnamon tree (cinnamon tree), Chrysanthemums, oak bark, stinging nettle, hops, burdock root, Horsetail, Hawthorn, Lime blossom, Almonds, Spruce needles, Sandalwood, Juniper, Coconut, Kiwi, Guava, Lime, Mango, Apricot, Wheat, Melon, Orange, Grapefruit, Avocado, Rosemary, Birch, Beech shoots, Meadowweed, Yarrow, Quender, Thyme, lemon balm, toadstool, marshmallow (Althaea), violet, blackcurrant leaves, coltsfoot, fünffingerkraut, ginseng, ginger root and sweet potato are preferred as another plant extract. Algae extracts can also be used to advantage. The algae extracts used according to the invention are derived from green algae, brown algae, red algae or blue-green algae (cyanobacteria). The algae used for extraction can be obtained both from natural sources as well as by biotechnological processes and, if desired, be modified from the natural form. The modification of the organisms can be carried out gen¬ technically, by breeding or by culturing in media enriched with selected Nähr¬. Preferred algae extracts are from seaweed, blue-green algae, from the green alga Codium tomentosum and from the brown algae Fucus vesiculosus. A particularly preferred algae extract is derived from blue-green algae of the species Spirulina, which were cultured in a magnesium-enriched medium.

Particularly preferred as a further plant extract are the extracts of spirulina, green tea, aloe vera, meristem, witch hazel, apricot, guava, sweet potato, lime, mango, kiwi, cucumber, mallow, marshmallow and violet. The compositions according to the invention may also contain, as an additional plant extract, mixtures of several, especially two, different plant extracts.

As extracting agent for the production of said further plant extracts, for example water, alcohols and mixtures thereof can be used, as well as for the preparation of the prebiotic plant extracts. Among the alcohols are lower alcohols such as ethanol and isopropanol, but especially polyhydric alcohols such as ethylene glycol, propylene glycol and butylene glycol both as sole extractant and in admixture with water, are preferred. Plant extracts based on water / propylene glycol in the ratio 1: 10 to 10: 1 have proven to be particularly proved suitable. The steam distillation according to the invention falls under the preferred extraction method. If appropriate, the extraction can also be carried out in the form of dry extraction.

The plant extracts can be used according to the invention both in pure and in diluted form. If they are used in diluted form, they usually contain about 2 to 80 wt .-% of active substance and as a solvent used in their extraction agent or extractant mixture. Depending on the choice of extractants, it may be preferable to stabilize the plant extract by adding a solubilizer. Suitable solubilizers are, for. B. Ethoxylation products of optionally hydrogenated vegetable and animal oils. Preferred solubilizing agents are ethoxylated mono-, di- and triglycerides of C _δ - ₂₂ -Fett- acids having 4 to 50 ethylene oxide units, for example. Hydrogenated ethoxylated castor oil, olive oil ethoxylate, almond oil ethoxylate, mink oil ethoxylate, polyoxyethylene glycol caprylic / capric acid glycerides, polyoxyethylene glycerol monolaurate, and polyoxyethylene glycol coconut fatty acid glycerides.

Furthermore, it may be preferable to use in the compositions according to the invention mixtures of several, in particular two, different plant extracts in addition to the plant extract or extracts used in the prebiotic active ingredient combination.

With regard to the plant extracts which can be used according to the invention, reference is furthermore made to the extracts listed in the table beginning on page 44 of the 3rd edition of the guideline for the ingredient declaration of cosmetic products, published by the Industrial Association for Personal Care and Detergent e.V. (IKW), Frankfurt.

The cosmetic or pharmaceutical compositions of the invention may further contain fatty substances. Fatty substances include fatty acids, fatty alcohols, natural and synthetic cosmetic oil components. and natural and synthetic waxes which may be in solid or liquid form in aqueous or oily dispersion.

As fatty acids can be used linear and / or branched, saturated and / or unsaturated C _8-3 o fatty acids. Preferred are C | _0-22 fatty acids. Examples are caproic acid, caprylic acid, 2-ethylhexanoic acid, capric acid, lauric acid, isotridecanoic acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, elaidic acid, petroselinic acid, linoleic acid, linolenic acid, elaeostearic acid, arachidonic acid, gadoleic acid, behenic acid and erucic acid, and technical mixtures thereof. Particularly preferred is the use of stearic acid. The fatty acids used can carry one or more hydroxyl groups. Preferred examples of these are the α-hydroxy-C ₈ -C ₈ -carboxylic acids and 12-hydroxystearic acid. The amount used is 0.1 to 15 wt .-%, preferably 0.5 to 10 wt .-%, particularly preferably 1 to 5 wt .-%, each based on the total composition.

As fatty alcohols it is possible to use saturated, mono- or polyunsaturated, branched or unbranched fatty alcohols having 6 to 30, preferably 10 to 22 and very particularly preferably 12 to 22 carbon atoms. Applicable according to the invention are e.g. Decanol, octanol, octenol, dodecenol, decenol, octadienol, dodecadienol, decadienol, oleyl alcohol, eruca alcohol, ricinoleic alcohol, stearyl alcohol, isostearyl alcohol, cetyl alcohol, lauryl alcohol, myristyl alcohol, arachidyl alcohol, capryl alcohol, capric alcohol, linoleyl alcohol, linolenyl alcohol and behenyl alcohol, and their guerbet alcohols.

For pen formulations waxes are often used. As natural or synthetic waxes can be used according to the invention are solid paraffins or isoparaffins, plant waxes such as candelilla wax, carnauba wax, Espartograswachs, Japan wax, cork wax, sugarcane wax, ouricury wax, montan wax, sunflower wax, fruit waxes and animal waxes such. B. beeswax and other insect waxes, spermaceti, shellac wax, wool wax and raffia fat, continue to mineral waxes such. Ceresin and Ozokerit or the petrochemical waxes such. B. petrolatum, paraffin waxes, Microwaxes of polyethylene or polypropylene and polyethylene glycol waxes. It may be advantageous to use hydrogenated or hardened waxes. Furthermore, chemically modified waxes, especially the hard waxes, z. B. Montan¬ ester waxes, Sasol waxes and hydrogenated jojoba waxes, can be used.

Also suitable are the mono-, di- and triglycerides of saturated and, where appropriate, hydroxylated C ₆ - ₃ o-fatty acids, such as. B. hydrogenated triglyceride fats (hydrogenated palm oil, hydrogenated coconut oil, hydrogenated castor oil), glyceryl monostearate (Cutina ^® MD), glyceryl hydroxystearate or glyceryl tri-12-, further ground synthetic Vollester of fatty acids and glycols (eg. B. Syncrowachs ^®) or poly- olen with 2 - 6 C-atoms, fatty acid monoalkanolamides with a C ₂ - ₂ 2-acyl group and a C _2-4 alkanol, esters of saturated and / or unsaturated and / or unbranched alkanecarboxylic acids branched with a chain length of 1 to 80 C- Atoms and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 1 to 80 carbon atoms, including z. Example, synthetic fatty acid fatty alcohol esters such as stearyl stearate or cetyl palmitate, esters of aromatic carboxylic acids, dicarboxylic acids or hydroxycarboxylic acids (eg., 12-hydroxystearic acid) and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of 1 to 80 C atoms, lactides of long-chain hydroxycarboxylic acids and full esters of fatty alcohols and di- and tricarboxylic acids, eg. As dicetylsuccinate or dicetyl / stearyl adipate, and mixtures of these substances, provided that the individual wax components or their mixture are solid at room temperature.

It is particularly preferred to choose the wax components from the group of esters of saturated, unbranched alkanecarboxylic acids having a chain length of 14 to 44 carbon atoms and saturated, unbranched alcohols of a chain length of 14 to 44 carbon atoms, provided the wax component or the entirety of the wax components are solid at room temperature. Particularly advantageously, the wax components may be selected from the group of C _6-36 alkyl stearates, the C _{0- 40} alkyl stearates, C _2-4 o-Alkylisostearate, the C ₂ o-4o-dialkyl esters of Dimersäu- reindeer, the Ci _{8- 38-} Alkylhydroxystearoylstearate, the C ₂ o- ₄ o-Alkylerucate wer¬ the, further C ₃₀ - ₅₀ -alkyl beeswax and Cetearylbehenat be used. Also Silicone waxes, for example stearyltrimethylsilane / stearyl alcohol, may be advantageous. Particularly preferred wax components are the esters of saturated, monohydric C ₂ oC ₆ o-alcohols and saturated C ₈ -C ₃₀ - monocarboxylic acids, in particular a C ₂ ° C ₄ o-alkyl stearate preferably, the Keunen under the name Kesterwachs ^® K82H by the company Koster Inc. is available. The wax or the wax components should solid at 25 ° C, but in the range of 35 - 95 ⁰ C melt, with a range from 45 to 85 ⁰ C is preferred.

Natural, chemically modified and synthetic waxes may be used alone or in combination.

The wax components are present in an amount of from 0.1 to 40% by weight, based on the total composition, preferably from 1 to 30% by weight and in particular from 5 to 15% by weight.

The compositions of the invention may further contain at least one nonpolar or polar liquid oil, which may be natural or synthetic. The polar oil component may be selected from vegetable oils, e.g. As sunflower oil, olive oil, soybean oil, rapeseed oil, almond oil, jojoba oil and the liquid portions of coconut oil and synthetic triglyceride oils, ester oils, that is, the esters of C ₆ -3o fatty acids with C ₂ - ₃ o-fatty alcohols, from dicarboxylic acid esters such as di n-butyl adipate, di- (2-ethylhexyl) adipate and di (2-ethylhexyl) succinate and diol esters such as ethylene glycol dioleate and propylene glycol di (2-ethylhexanoate), from symmetrical, unsymmetrical or cyclic esters of carbonic acid with fatty alcohols, for example described in DE-OS 197 56 454, glycerol carbonate or dicaprylyl carbonate (Cetiol ^® CC), of mono, - di- and Trifettsäureestem of saturated and / or unsaturated linear and / or branched fatty acids with glycerol, of branched alkanols, for example. B. Guerbet alcohols having a single branch on the carbon atom 2 such as 2-hexyldecanol, 2-octyldodecanol, isotridecanol and isohexadecanol, from alkanediols, eg. B. from Epoxyalkanen with 12 - 24 carbon atoms by ring opening with water available vicinal diols from Ether alcohols, eg. As the monoalkyl ethers of glycerol, ethylene glycol, 1, 2-propylene glycol or 1, 2-butanediol, from dialkyl ethers each having 12 - 24 carbon atoms, eg. Example, the alkyl methyl ether or di-n-alkyl ethers, each having a total of 12 to 24 carbon atoms, in particular di-n-octyl ether (Cetiol ^® OE ex Cognis), as well as adducts of ethylene oxide and / or propylene oxide to mono- or polyvalent C ₃ - ₂ o-alkanols such as butanol and glycerol, z. PPG-3-myristyl ether (Witconol APM ^®), PPG-14 butyl ether (Ucon Fluid ^® AP) PPG-15 stearyl ether (Arlamol ^® E), PPG-9-butyl ether (Breox B25 ^®) and PPG-10 butanediol (Macol ^® 57). The non-polar oil component may be selected from liquid paraffin oils, isoparaffin oils, e.g. Isohexadecane and isoeicosane, from hydrogenated polyalkenes, especially poly-1-decenes (commercially available as Nexbase 2004, 2006 or 2008 FG (Fortum, Belgium)), from synthetic hydrocarbons, e.g. B. 1, 3-di- (2-ethyl-hexyl) -cyclohexane (Cetiol ^® S), as well as volatile and nonvolatile silicone oils, the cyclic, such as. For example, decamethylcyclopentasiloxane and dodecamethylcyclohexasiloxane, or may be linear, e.g. As linear dimethylpolysiloxane, commercially available z. Example under the name Dow Corning ^® 190, 200, 244, 245, 344 or 345 and Baysilon ^® 350 M.

The compositions of the invention may further contain at least one water-soluble alcohol. Water solubility is understood according to the invention that at least 5 wt .-% of the alcohol at 20 ° C clear dissolve or - in the case of long-chain or polymeric alcohols - by heating the solution to 50 ° C to 60 ° C can be brought into solution. Suitable depending on the dosage form monohydric alcohols such. As ethanol, propanol or isopropanol. Also suitable are water-soluble polyols. These include water-soluble diols, triols and higher alcohols and polyethylene glycols. Among the diols are C ₂ -Ci ₂ -DJoIe, in particular 1, 2-propylene glycol, butylene glycols such. For example, 1, 2-butylene glycol, 1, 3-butylene glycol and 1, 4-butylene glycol, hexanediols such as. B. 1, 6-hexanediol. Also suitable are preferably glycerol and in particular diglycerol and triglycerol, 1, 2,6-hexanetriol and the dipropylene glycol and the polyethylene glycols (PEG) PEG-400, PEG-600, PEG-1000, PEG-1550, PEG-3000 and PEG-4000 , The amount of the alcohol or the alcohol mixture in the compositions according to the invention is 1-50 or 1-70% by weight and preferably 5-40 or 5-55% by weight, based on the total composition. According to the invention, both an alcohol and a mixture of several alcohols can be used.

The compositions of the invention may be substantially anhydrous, that is, contain at most 5 wt .-%, preferably at most 1 wt .-% water. In water-containing administration forms, the water content is 5 to 98% by weight, preferably 10 to 90 and particularly preferably 15 to 85% by weight, based on the total composition.

The compositions of the invention may further comprise at least one hydrophilic modified silicone. They allow the formulation of highly transparent compositions, reduce the stickiness and leave a fresh feeling on the skin. Hydrophilically modified silicones are understood according to the invention to mean polyorganosiloxanes having hydrophilic substituents which cause the water solubility of the silicones. According to the invention is understood to mean water-solubility that is at least 2 wt .-% resolve the modified with hydrophilic groups silicone in water at 20 ⁰ C. Corresponding hydrophilic substituents are, for example, hydroxy, polyethylene glycol or polyethylene glycol / polypropylene glycol side chains and ethoxylated ester side chains. According to the invention suitable are hydrophilic modified silicone copolyols, especially dimethicone copolyols, under, for example, from Wacker-Chemie under the name Belsil ^® DMC 6031, Belsil ^® DMC 6032, Belsil ^® DMC 6038 or Belsil ^® DMC 3071 VP or from Dow Corning the name DC 2501 are commercially available. Particularly suitable is the use of Belsil ^® DMC 6038, since it allows the formulation of hoch¬ transparent compositions, which reach a higher consumer acceptance. As a hydrophilic silicone derivative, it is also possible to use, for example, ABIL EM97 from Degussa / Goldschmidt. According to the invention, it is also possible to use any desired mixture of the silicones mentioned. The amount of the hydrophilic modified silicone or the alcohol mixture in the compositions according to the invention is 0.5-10% by weight, preferably 1-8% by weight and more preferably 2-6% by weight, based on the total weight of the Composition.

The compositions of the invention may further contain emulsifiers and / or surfactants. In a particularly preferred embodiment, this was addition products of 10 to 40 moles of ethylene oxide to linear or branched fatty alcohols having 16 to 22 carbon atoms, to fatty acids having 12

22 C atoms, fatty acid alkanolamides, fatty acid monoglycerides, sorbitan fatty acid monoesters, fatty acid alkanolamides, fatty acid glycerides, e.g. hydrogenated castor oil, methylglucoside mono-fatty acid esters and mixtures thereof. In principle, however, any other emulsifiers and / or surfactants can be used.

Emulsifiers which can be used according to the invention in this sense are, for example

Addition products of 4 to 30 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide onto linear or branched C ₈ -C ₂₂ -fatty alcohols, on C ₂ -C ₂₂ -fatty acids and on C ₈ -C ₅ -alkylphenols,

C ₂ -C ₂₂ -fatty acid mono- and diesters of addition products of from 1 to 30 mol of ethylene oxide onto C ₃ -C ₆ -polyols, in particular to glycerol,

Ethylene oxide and polyglycerol addition products to methyl glucoside fatty acid esters, fatty acid alkanolamides and fatty acid glucamides,

C ₈ -C ₂₂ -alkylmono- and -oligoglycosides and their ethoxylated analogues, preference being given to degrees of oligomerization of from 1.1 to 5, in particular from 1.2 to 2.0, and glucose as the sugar component,

- Mixtures of alkyl (oligo) glucosides and fatty alcohols, eg. As the commercially available product Montanov ^® 68,

Addition products of from 5 to 60 mol of ethylene oxide onto castor oil and hydrogenated castor oil, Partial esters of polyols having 3-6 carbon atoms with saturated C ₈ -C ₂₂ fatty acids,

- Sterols (sterols). Sterols are understood to mean a group of steroids which have a hydroxyl group on C-atom 3 of the steroid skeleton and are isolated both from animal tissue (zoosterols) and from vegetable fats (phytosterols). Examples of zoosterols are cholesterol and lanosterol. Examples of suitable phytosterols are beta-sitosterol, stigmasterol, campesterol and ergosterol. From mushrooms and yeasts sterols, the so-called mycosterols, isolated.

- Phospholipids, especially the glucose phospholipids, the z. B. as lecithins or phosphatidylcholines from z. Egg yolks or plant seeds (eg soybeans),

Fatty acid esters of sugars and sugar alcohols such as sorbitol,

- polyglycerols and polyglycerol, preferably Polyglyceryl-2 dipolyhydroxystearate (Dehymuls ^® PGPH commercial product) and polyglyceryl-3-diisostearate (Lameform ^® TGI commercial product)

- Linear and branched C ₈ -C ₃ o fatty acids and their Na, K, ammonium, Ca, Mg and Zn salts.

The agents according to the invention preferably contain the emulsifiers in amounts of 0.1 to 25% by weight, in particular 0.5 to 15% by weight, based on the total agent.

In another, likewise preferred embodiment, at least one ionic emulsifier, selected from anionic, zwitterionic, ampholytic and cationic emulsifiers, is contained. Preferred anionic emulsifiers are alkyl sulfates, alkyl polyglycol ether sulfates and ether carboxylic acids having 10 to 18 C atoms in the alkyl group and up to 12 glycol ether groups in the molecule, sulfosuccinic acid mono- and dialkyl esters having 8 to 18 C atoms in the alkyl group and sulfosuccinic acid monoalkylpolyoxyethyl ester with 8 to 18 carbon atoms in the alkyl group and 1 to 6 oxyethyl groups, monoglyceride sulfates, alkyl and alkenyl ether phosphates and protein fatty acid condensates. Zwitterionic emulsifiers carry at least one quaternary ammonium group and at least one -COO ^" or -SO ₃ ^' group in the molecule Particularly suitable zwitterionic emulsifiers are the so-called betaines such as the N-alkyl-N, N-dimethylammonium glycinates, N-acyl aminopropyl-N, N-dimethylammonium glycinates and 2-alkyl-3-carboxymethyl-3-hydroxyethyl-imidazolines having in each case 8 to 18 C atoms in the alkyl or acyl group, and the cocoacylaminoethylhydroxyethylcarboxymethylglycinate.

Ampholytic emulsifiers contain, in addition to a C ₈ -C ₂₄ -alkyl or -acyl group, at least one free amino group and at least one -COOH or -SO ₃ H group in the molecule and can form internal salts. Examples of suitable ampholytic emulsifiers are N-alkylglycines, N-alkylaminopropionic acids, N-alkylaminobutyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropylglycines, N-alkyltaurines, N-alkylsarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acids each having about 8 to 24 C atoms in the alkyl group.

The ionic emulsifiers are contained in an amount of 0.01 to 5 wt .-%, preferably from 0.05 to 3 wt .-% and particularly preferably from 0.1 to 1 wt .-%, based on the total agent ,

Nonionic surfactants which can be used according to the invention are, for example:

- alkoxylated fatty acid alkyl esters of the formula R ¹ CO- (OCH ₂ CHR ² ) _X OR ³ , in which R ¹ CO is a linear or branched, saturated and / or unsaturated acyl radical having 6 to 22 carbon atoms, R ^{2 is} hydrogen or methyl, R ^{3 represents} linear or branched alkyl radicals having 1 to 4 carbon atoms and x represents numbers from 1 to 20,

Adducts of ethylene oxide with fatty acid alkanolamides and fatty amines,

Fatty acid N-alkylglucamides,

- Cs - C ₂₂ ~ alkylamine N-oxides,

- Alkylpolygykoside according to the general formula RO- (Z) _x wherein R is a Cs-Ci ₆ alkyl group, Z is sugar and x is the number of sugar units. The alkyl polyglycosides which can be used according to the invention may only contain a particular alkyl radical R. Usually, however, these compounds are prepared starting from natural fats and oils or mineral oils. In this case, the alkyl radicals R are mixtures corresponding to the starting compounds or corresponding to the particular work-up of these compounds. And Cu-alkyl groups, mainly of Ce to C ₆ alkyl groups or substantially of C ₁₂ - - Particularly preferred alkyl polyglycosides are those in which R consists essentially of Ca and C-io alkyl groups essentially of ₁₂ are C- to C ₁₆ - alkyl groups.

As sugar building block Z it is possible to use any desired mono- or oligosaccharides. Usually, sugars having 5 or 6 carbon atoms and the corresponding oligosaccharides are used, for example glucose, fructose, galactose, arabinose, ribose, xylose, lyxose, allose, altrose, mannose, gulose, idose, talose and sucrose. Preferred sugar building blocks are glucose, fructose, galactose, arabinose and sucrose; Glucose is particularly preferred. The alkyl polyglycosides which can be used according to the invention contain on average from 1.1 to 5, preferably from 1.1 to 2.0, particularly preferably from 1.1 to 1.8, sugar units. The alkoxylated homologs of said alkyl polyglycosides can also be used according to the invention. These homologs may contain on average up to 10 ethylene oxide and / or propylene oxide units per alkyl glycoside unit.

Zwitterionic surfactants surface-active compounds are suitable which have at least one quaternary ammonium group and at least one -COO ^ in the molecule - wear or -SO ₃ ^W group. Particularly suitable zwitterionic surfactants are the so-called betaines such as N-alkyl-N, N-dimethylammonium glycinates, for example cocoalkyldimethylammonium glycinate, N-acylaminopropyl-N, N-dimethylammonium glycinates, for example cocoacylaminopropyldimethylammonium glycinate, and 2-alkyl-3 carboxymethyl-3-hydroxyethyl-imidazolines having in each case 8 to 18 carbon atoms in the alkyl or acyl group, and the cocoacylaminoethylhydroxyethylcarboxymethylglycinate. A preferred zwitterionic surfactant is the fatty acid amide derivative known by the INCI name Cocamidopropyl Betaine. Suitable anionic surfactants in compositions according to the invention are all anionic surface active substances suitable for use on the human body. These are characterized by a water-solubilizing, anionic group such as. As a carboxylate, sulfate, sulfonate or phosphate group and a lipophilic alkyl group having about 8 to 30 carbon atoms. In addition, glycol or polyglycol ether groups, ester, ether and amide groups and hydroxyl groups may be present in the molecule. Examples of suitable foaming anionic surfactants are, in each case in the form of the sodium, potassium and ammonium as well as the mono-, di- and trialkanolammonium salts having 2 to 4 carbon atoms in the alkanol group, acylglutamates of the formula (II),

XOOC-CH ₂ CH ₂ CH-COOX (II)

HN-COR ¹

in which R ¹ CO is a linear or branched acyl radical having 6 to 22 carbon atoms and 0, 1, 2 or 3 double bonds and X is hydrogen, an alkali and / or alkaline earth metal, ammonium, alkylammonium, alkanolammonium or glucammonium, for example acylglutamates, derived from fatty acids having from 6 to 22, preferably 12 to derive up to 18 carbon atoms, such as C 12 _/ 14- or C12 / 18 coconut fatty acid, lauric acid, myristic acid, palmitic acid and / or stearic acid, particularly sodium N-cocoyl and sodium N-stearoyl-L-glutamate,

Esters of a hydroxy-substituted di- or tricarboxylic acid of the general formula (III),

X

HO - C - COOR ¹ (III)

Y _ CH - COOR ² wherein X is H or a -CH ₂ COOR group, Y is H or -OH, under the condition that Y is H when X-CH ₂ COOR, R, R ¹ and R ^{2 are} independently Hydrogen atom, an alkali or alkaline earth metal cation, an ammonium group, the cation of an ammonium organic base or a radical Z derived from a polyhydroxylated organic compound selected from the group of etherified (C ₆ -C 18) alkyl polysaccharides having 1 to 6 monomeric saccharide units and / or the etherified aliphatic (C ₆ -C ₆ ) hydroxyalkylpolyols having 2 to 16 hydroxyl radicals are selected, provided that at least one of the groups R, R ¹ or R ^{2 is} a radical Z, esters of sulfosuccinic acid salt of the general formula (IV),

H ₂ C - COOR ¹ (IV)

O ₃ S - CH - COOR ²

in which R ¹ and R ² independently of one another denote a hydrogen atom, an alkali metal or alkaline earth metal cation, an ammonium group, the cation of an ammonium organic base or a radical Z derived from a polyhydroxylated organic compound selected from the group of the United ¬ etherten (C ₆ -C ₈₎ -Alkylpolysaccharide having 1 to 6 monomeric units Saccharidein¬ and / or etherified aliphatic (C ₆ -C ₁₆₎ -hydroxyalkylpolyols having 2 to 16 hydroxyl radicals is selected, with the proviso that at least one Groups R ¹ or R ^{2 is} a radical Z,

Sulfosuccinic acid mono- and dialkyl esters having 8 to 24 C atoms in the alkyl group and sulfosuccinic monoalkylpolyoxyethyl esters having 8 to 24 C atoms in the alkyl group and 1 to 6 ethoxy groups, esters of tartaric acid and citric acid with alcohols, the Anla¬ tion products of about 2-15 Molecules ethylene oxide and / or propylene oxide to fatty alcohols having 8 to 22 carbon atoms, linear and branched fatty acids having 8 to 30 carbon atoms (soaps), ether carboxylic acids of the formula RO- (CH ₂ -CH ₂ O) _x -CH ₂ - COOH in which R is a linear alkyl group having 8 to 30 carbon atoms and x = 0 or 1 to 16, Acylsarcosinates having a linear or branched acyl radical having 6 to 22 carbon atoms and 0, 1, 2 or 3 double bonds,

Acyl taurates having a linear or branched acyl radical having 6 to 22 carbon atoms and 0, 1, 2 or 3 double bonds,

Acyl isethionates having a linear or branched acyl radical having 6 to 22 carbon atoms and 0, 1, 2 or 3 double bonds,

- linear alkanesulfonates having 8 to 24 carbon atoms,

- linear alpha-olefin sulfonates having 8 to 24 carbon atoms,

Alpha-sulfofatty acid methyl esters of fatty acids having 8 to 30 C atoms,

- Alkylsulfate and Alkylpolyglykolethersulfate of the formula RO (CH ₂ -CH ₂ O) ₂ -SO ₃ X, in which R is a preferably linear alkyl group having 8 to 30 carbon atoms, more preferably having 8 - 18 carbon atoms, z = 0 or 1 to 12, more preferably 3, and X is a sodium, potassium, magnesium, zinc, ammonium or a monoalkanol, dialkanol or Trialkanolammoniumion having 2 to 4 carbon atoms in the alkanol group, with a particularly preferred example of zinc cocoyl ether sulfate with a degree of ethoxylation of z = 3,

Mixtures of surface-active hydroxysulfonates according to DE-A-37 25 030,

sulfated hydroxyalkylpolyethylene and / or hydroxyalkylene-propylene glycol ethers according to DE-A-37 23 354,

Sulfonates of unsaturated fatty acids having 8 to 24 C atoms and 1 to 6 double bonds according to DE-A-39 26 344,

Alkyl and / or alkenyl ether phosphates of the formula (V),

O

R- (OCH ₂ CH ₂ ) _n -O-P-OR ² (V)

OX

in which R ^{1 is} preferably an aliphatic hydrocarbon radical having 8 to 30 carbon atoms, R ^{2 is} hydrogen, a radical (CH ₂ CH ₂ O) _n R ¹ or X, n is from 1 to 10 and X is hydrogen, an alkali or alkaline earth metal or NR ³ R ⁴ R ⁵ R ⁶ , where R ³ to R ⁶ independently of one another represent a C ¹ to C ₄ hydrocarbon radical,

- Sulfated fatty acid alkylene glycol esters of the formula R ⁷ CO (AIkO) _n SO ₃ M, in the R ⁷ CO- for a linear or branched, aliphatic, saturated and / or unsaturated acyl radical having 6 to 22 carbon atoms, Alk is CH ₂ CH ₂ , CHCH ₃ CH ₂ and / or CH ₂ CHCH ₃ , n is from 0.5 to 5 and M is a cation as described in DE -OS 197 36 906.5 are described,

Monoglyceride sulphates and monoglyceride ether sulphates of the formula (VI),

CH ₂ θ (CH ₂ CH ₂ θ) _χ - COR 8 CHO (CH ₂ CH ₂ CO y H (VI)

CH ₂ O (CH ₂ CH ₂ O) ₂ - SO ₃ X

- In which R ⁸ CO is a linear or branched acyl radical having 6 to 22 carbon atoms, x, y and z in total for O or for numbers from 1 to 30, preferably 2 to 10, and X is an alkali or alkaline earth metal. Typical examples of monoglyceride (ether) sulfates suitable for the purposes of the invention are the reaction products of lauric acid monoglyceride, coconut fatty acid monoglyceride, palmitic acid monoglyceride, stearic acid monoglyceride, oleic acid monoglyceride and tallow fatty acid monoglyceride and their ethylene oxide adducts with sulfur trioxide or chlorosulfonic acid in the form of their sodium salts. Monoglyceride sulfates of the formula (VI) in which R ⁸ CO is a linear acyl radical having 8 to 18 carbon atoms are preferably used.

Furthermore, the compositions according to the invention may contain at least one protein hydrolyzate or its derivative. Both vegetable and animal protein hydrolysates can be used according to the invention. Animal protein hydrolysates are z. B. elastin, collagen, keratin, silk and milk protein protein hydrolysates, which may also be in the form of salts. Vegetable protein hydrolysates, eg. Soy, wheat, almonds, peas, potato and rice protein hydrolysates. Corresponding commercial products are z. B. DiaMin® ^® (Diamalt) Gluadin ^® (Cognis), Lexein ^® (Inolex) and Crotein ^® (Croda).

Instead of the protein hydrolysates, amino acid mixtures obtained on the one hand and, on the other hand, individual amino acids and their amino acids can also be used Physiologically acceptable salts are used. The inventively preferred amino acids include glycine, serine, threonine, cysteine, asparagine, glutamine, pyroglutamic acid, alanine, valine, leucine, isoleucine, proline, tryptophan, phenylalanine, methionine, aspartic acid, glutamic acid, lysine, arginine and histidine and the zinc salts and Acid addition salts of said amino acids.

Also possible is the use of derivatives of protein hydrolysates, z. In the form of their fatty acid condensation products. Corresponding commercial products are z. B. Lamepon ^® (Cognis), Gluadin ^® (Cognis), Lexein ^® (Inolex), Crolastin ^{® ®} or Crotein (Croda).

Cationized protein hydrolysates can also be used according to the invention, it being possible for the underlying protein hydrolyzate to originate from the animal, from the plant, from marine life forms or from biotechnologically obtained protein hydrolysates. Preference is given to cationic protein hydrolysates whose protein content on which they are based has a molecular weight of from 100 to 25,000 daltons, preferably from 250 to 5,000 daltons. Furthermore, cationic protein hydrolyzates are understood to mean quaternized amino acids and mixtures thereof. Furthermore, the cationic protein hydrolysates may also be further derivatized. As typical examples of cat¬ ionic protein hydrolysates and derivatives used according to the invention, some of the INCI names in the International Cosmetic Ingredient Dictionary and Handbook, (seventh edition 1997, The Cosmetic, Toiletry, and Fragrance Association 1101 17 ^th Street Cocodimonium Hydroxypropyl Hydrolyzed Collagen, Cocodimonium Hydroxypropyl Hydrolyzed Casein, Steardimonium Hydroxypropyl Hydrolyzed Collagen, Steardimonium Hydroxypropyl Hydrolyzed Hair Keratin, Lauryldimonium Hydroxypropyl Hydrolyzed Keratin, Cocodimonium Hydroxypropyl Hydrolyzed Rice Protein, Cocodimonium Hydroxypropyl Hydrolyzed SiCl, Cocodimonium Hydroxypropyl Hydrolyzed Soy Protein, Cocodimonium Hydroxypropyl Hydrolyzed Wheat Protein, Cocodimonium Hydroxypropyl SiCl Amino Acids, Hydroxypropyl Arginine Lauryl / myristyl ether HCl, hydroxypropyltrimonium gelatin. Very particular preference is given to the cationic protein hydrolysates and derivatives based on plants.

In the compositions according to the invention are the protein hydrolysates and their derivatives or the amino acids and their derivatives in amounts of up to 10 wt .-%, based on the total agent included. Amounts of from 0.1 to 5% by weight, in particular from 0.1 to 3% by weight, are particularly preferred.

Furthermore, the compositions according to the invention may contain at least one mono-, oligo- or polysaccharide or derivatives thereof.

According to the invention suitable monosaccharides are z. As glucose, fructose, galactose, arabinose, ribose, xylose, lyxose, allose, altrose, mannose, gulose, idose and talose, the deoxy sugars fucose and rhamnose and amino sugars such. As glucosamine or galactosamine. Preferred are glucose, fructose, galactose, arabinose and fucose; Glucose is particularly preferred.

According to the invention suitable oligosaccharides are composed of two to ten monosaccharide units, for. As sucrose, lactose or trehalose. A particularly preferred oligosaccharide is sucrose. Also particularly preferred is the use of honey, which contains predominantly glucose and sucrose.

Polysaccharides which are suitable according to the invention are composed of more than ten monosaccharide units. Preferred polysaccharides are the starches made from α-D-glucose units and starch degradation products such as amylose, amylopectin and dextrins. Particularly advantageous according to the invention are chemically and / or thermally modified starches, for. Hydroxypropyl starch phosphate, dihydroxypropyldistarch phosphate or the commercial products Dry ^Flo® . Further preferred are dextrans and their derivatives, eg. B. dextran sulfate. Also preferred are nonionic cellulose derivatives, such as methylcellulose, hydroxypropylcellulose or hydroxyethylcellulose, and also cationic cellulose derivatives, z. , The commercial products Celquat ^® and Polymer JR ^®, and preferably Celquat ^® H 100, Celquat L 200 and Polymer JR ^{® ®} 400 (Polyquaternium-10) as well as Polyquaternium-24th Further preferred examples are polysaccharides from fucose units, e.g. B. the commercial product Fucogel ^® . Particularly preferred are the polysaccharides composed of amino sugar units, in particular chitins and their deacetylated derivatives, the chitosans, and mucopolysaccharides. The inventively preferred mucopolysaccharides include hyaluronic acid and its derivatives, e.g. As sodium hyaluronate or Dimethylsilanolhyaluronat, and chondroitin and its derivatives, for. B. chondroitin sulfate.

In an advantageous embodiment, the inventive

Compositions at least one film-forming, emulsion-stabilizing, thickening or adhesive polymer selected from natural and synthetic polymers which may be cationic, anionic, amphoteric or nonionic.

According to the invention, preference is given to cationic, anionic and nonionic

Polymers.

Preferred among the cationic polymers are polysiloxanes having quaternary groups, e.g. , The commercial products Q2-7224 (Dow Corning), Dow Corning ^® 929 Emulsion (with amodimethicone), SM-2059 (General Electric), SLM-55067 (Wacker) and Abil ^® -Quat 3270 and 3272 (Th. Goldschmidt).

Preferred anionic polymers which can support the action of the active ingredient used according to the invention comprise carboxylate and / or sulfonate groups and as monomers, for example, acrylic acid, methacrylic acid, crotonic acid, maleic anhydride and 2-acrylamido-2-methylpropanesulfonic acid. The acidic groups may be wholly or partly present as sodium, potassium, ammonium, mono- or triethanolammonium salt. Preferred monomers are 2-acrylamido-2-methylpropanesulfonic acid and acrylic acid. Very particularly preferred anionic polymers contain 2-acrylamido-2-methylpropanesulfonic acid as the sole monomer or as comonomer, it being possible for the sulfonic acid group to be wholly or partly in salt form. Within this Embodiment, it is preferred to use copolymers of at least one anionic monomer and at least one nonionic monomer. With regard to the anionic monomers, reference is made to the substances listed above. Preferred nonionic monomers are acrylamide, methacrylamide, acrylic esters, methacrylic esters, vinylpyrrolidone, vinyl ethers and vinyl esters. Preferred anionic copolymers are acrylic acid-acrylamide copolymers and in particular polyacrylamide copolymers with sulfonic acid-containing monomers. A particularly preferred anionic copolymer consists of 70 to 55 mol% of acrylamide and 30 to 45 mol% of 2-acrylamido-2-methylpropanesulfonic acid, the sulfonic acid groups being wholly or partly in the form of sodium, potassium, ammonium, mono- or triethanolammo- nium salt present. This copolymer may also be crosslinked, with crosslinking agents preferably polyolefinically unsaturated compounds such as tetraallyloxyethane, Allylsucrose, AIIy Ipentaeryth rit and methylene-bisacrylamide are used. Such a polymer is contained in the commercial product Sepigel ^® 305 from SEPPIC. The use of this compound has proved to be particularly advantageous in the context of the teaching according to the invention. Also known as compound with isohexadecane and poly sold under the name Simulgel® ^® 600 sorbate-80 sodium acryloyldimethyltaurate copolymers have proven effective as inventively particularly.

Further preferred anionic homo- and copolymers are uncrosslinked and crosslinked polyacrylic acids. Allyl ethers of pentaerythritol, sucrose and propylene may be preferred crosslinking agents. Such compounds are for example the commercial products Carbopol ^®. A particularly preferred anionic copolymer contains as monomer 80-98% of an unsaturated, optionally substituted C _3-6 carboxylic acid or its anhydride and 2-20% of optionally substituted acrylic acid esters of saturated Cio ₃ o carboxylic acids, wherein the copolymer can be crosslinked with the aforementioned crosslinking agents. Corresponding commercial products are Pemulen ^® and Carbopol ^® grades 954, 980, 1342 and ETD 2020 (ex BF Goodrich). Suitable nonionic polymers include polyvinyl alcohols, which may be partially saponified, for. B. the commercial products Mowiol ^® and vinylpyrrolidone / vinyl ester copolymers and polyvinylpyrrolidones z. B. under the trademark Luviskol ^® (BASF) are sold.

The compositions according to the invention may further contain at least one α-hydroxycarboxylic acid or α-ketocarboxylic acid or their ester, lactone or salt form. Suitable α-hydroxycarboxylic acids or α-ketocarboxylic acids are selected from lactic acid, tartaric acid, citric acid, 2-hydroxybutanoic acid, 2,3-dihydroxypropanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxyheptanoic acid, 2-hydroxyoctanoic acid, 2-hydroxydecanoic acid, 2-hydroxydodecanoic acid , 2-hydroxytetradecanoic acid, 2-hydroxyhexadecanoic acid, 2-hydroxyoctadecanoic acid, mandelic acid, 4-hydroxymandelic acid, malic acid, erythraric acid, threaric acid, glucaric acid, galactaric acid, mannaric acid, gular acid, 2-hydroxy-2-methylsuccinic acid, gluconic acid, pyruvic acid, glucuronic acid and galacturonic acid. The esters of said acids are selected from the methyl, ethyl, propyl, isopropyl, butyl, amyl, pentyl, hexyl, 2-ethylhexyl, octyl, decyl, dodecyl and hexadecyl esters. The α-hydroxycarboxylic acids or α-ketocarboxylic acids or their derivatives are present in amounts of from 0.1 to 10% by weight, preferably 0.5 to 5% by weight, in each case based on the total composition.

The compositions of the invention may contain other active ingredients, auxiliaries and additives, for example:

- Vitamins, provitamins and vitamin precursors from groups A, C, E and F, in particular 3,4-didehydroretinol (vitamin A ₂ ), ß-carotene (provitamin of vitamin Ai), ascorbic acid (vitamin C), and the palmitic acid esters, glucosides or phosphates of ascorbic acid, tocopherols, in particular α-tocopherol and its esters, for. The acetate, the nicotinate, the phosphate and the succinate; vitamin F, which is understood as meaning essential fatty acids, especially linoleic acid, linolenic acid and arachidonic acid; - an ester of retinol (vitamin Ai) with a C ₂ i ₈ carboxylic acid, in particular retinyl acetate or retinyl palmitate.

Vitamins, provitamins or vitamin precursors of the vitamin B group or derivatives thereof and derivatives of 2-furanone, in particular vitamin Bi (thiamine), vitamin B ₂ (riboflavin), vitamin B ₃ (nicotinic acid and / or nicotinic acid amide), vitamin B ₅ ( Pantothenic acid and / or panthenol), vitamin B ₆ (pyridoxine, pyridoxamine and / or pyridoxal) and / or vitamin B ₇ (biotin),

- allantoin,

- bisabolol,

- lactic acid,

Antioxidants, for example imidazoles (for example urocanic acid) and derivatives thereof, peptides such as D, L-camosine, D-carnosine, L-carnosine and their derivatives (for example anserine), chlorogenic acid and its derivatives, lipoic acid and their derivatives (eg dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (eg thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl) , Amyl, butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof (esters, ethers, peptides, lipids, nucleotides , Nucleosides and salts) and sulfoximine compounds (eg buthionine sulfoximines, homocysteine sulfoximine, bithine sulfones, penta, hexa, heptathionine sulfoximine) in very low tolerated dosages (eg pmol to μmol / kg), furthermore (metal) chelators ( for example, α-hydroxy fatty acids, palmitic acid, phytic acid , Lactoferrin), humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g. Gamma-linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and ubiquinol and derivatives thereof, the benzylic resin coniferyl benzoate, rutinic acid and derivatives thereof, α-glycosylrutin, ferulic acid, furfurylidene glucitol, carnosine, butylhydroxytoluene, butylhydroxyanisole, nordihydroguaiacetic acid , Nordihydroguajaretsäure, Trihydroxybutyrophenon, uric acid and their derivatives, catalase, superoxide dismutase, zinc and its derivatives (eg ZnO, ZnSO ₄ ), selenium and its derivatives (eg selenium methionine), stilbenes and their derivatives (eg stilbene oxide, trans-stilbene oxide) and the antioxidant-suitable derivatives (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these active substances,

Ceramides and pseudoceramides,

Triterpenes, in particular triterpenic acids such as ursolic acid, rosmarinic acid, betulinic acid, boswellic acid and bryonolic acid,

- Monomeric catechins, especially catechin and epicatechin, leucoanthocyanidins, catechin polymers (catechin tannins) and gallotannins,

- Thickener, z. As gelatin, plant matter such as agar-agar, guar gum, alginates, xanthan gum, gum arabic, karaya gum or locust bean gum, natural and synthetic clays and Schicht¬ silicates, z. As bentonite, hectorite, montmorillonite or Laponite ^® , fully synthetic hydrocolloids such. Polyvinyl alcohol, and also Ca, Mg or Zn soaps of fatty acids,

- vegetable glycosides,

- structurants such as maleic acid and lactic acid,

- dimethyl isosorbide,

Alpha, beta and gamma cyclodextrins, in particular for the stabilization of retinol,

- Solvents, swelling and penetrating agents such as ethanol, isopropanol, ethylene glycol, propylene glycol, propylene glycol monoethyl ether, glycerol and diethylene glycol, carbonates, bicarbonates, guanidines, ureas and primary, secondary and tertiary phosphates

Perfume oils, pigments and dyes for staining the agent,

- substances for adjusting the pH, z. B. α- and ß-hydroxy-carboxylic acids, Complexing agents such as EDTA, NTA, β-alaninediacetic acid and phosphonic acids,

Opacifiers such as latex, styrene / PVP and styrene / acrylamide copolymers,

Pearlescing agents such as ethylene glycol mono- and distearate and PEG-3-distearate,

Propellants such as propane-butane mixtures, N ₂ O, dimethyl ether, CO ₂ and air,

MMP-1-inhibiting substances, in particular selected from photolyase and / or T4 endonuclease V, propyl gallate, precocenes, 6-hydroxy-7-methoxy-2,2-dimethyl-1 (2H) -benzopyran and 3,4-dihydroxy 6-hydroxy-7-methoxy-2,2-dimethyl-1 (2H) -benzopyran,

- Organic, mineral and / or modified mineral sunscreen filters, in particular UVA filters and / or UVB filters.

The compositions of the invention may further contain antiperspirant active ingredients. Suitable antiperspirant active compounds according to the invention are water-soluble astringent or protein-coagulating metallic salts, in particular inorganic and organic salts of aluminum, zirconium, zinc and titanium, as well as any mixtures of these salts. A solubility of at least 4 g of active substance per 100 g solution according to the invention is understood at 20 ⁰ C under water solubility. For example, alum (KAl (SO ₄ ) ₂ ^.12H ₂ O), aluminum sulfate, aluminum lactate, sodium aluminum chlorhydroxactate, aluminum chlorohydrate, aluminum chlorohydrate, aluminum sulfocarbolate, aluminum zirconium chlorohydrate, zinc chloride, zinc sulfocarbolate, zinc sulfate , Zirconium chlorohydrate, aluminum-zirconium-chlorohydrate-glycine complexes and complexes of basic aluminum chlorides with propylene glycol or polyethylene glycol. The liquid active substance preparations preferably comprise an astringent aluminum salt, in particular aluminum chlorohydrate, and / or an aluminum-zirconium compound. Alumini¬ umchlorohydrate example, powdery Micro Dry ^® Ultrafine or distributed as in activated form as Reach ^® 501 or Reach ^® 103 from Reheis and in the form of aqueous solutions as Locron ^® L of Clariant ^® or as Chlorhydrol from Reheis. Under the name Reach ^® 301, an aluminum sesquichlorohydrate offered by Reheis. Also, the use of aluminum-zirconium tri- or tetrachlorohydrex glycine complexes, which are, for example, from Reheis under the name Rezal 36G ^® commercially, according to the invention is particularly advantageous.

The antiperspirant active may be present in the compositions of the invention, for example, in an amount of from 0.01 to 40% by weight, preferably from 2 to 30% by weight and in particular from 5 to 25% by weight, based on the amount of active substance in total Composition, included.

The compositions of the invention may further contain deodorant agents and / or preservatives. Fragrance, antimicrobial, antibacterial or germ-inhibiting substances as well as enzyme-inhibiting substances, antioxidants and odor adsorbents are suitable according to the invention as deodorant active ingredients. The deodorant agents, preservatives or antibacterial agents are preferably used in concentrations that do not lead to an unselective killing of the microflora in the genital area.

Particularly suitable are organohalogen compounds and halides, quaternary ammonium compounds and zinc compounds. Chlorohexidine and chlorhexidine gluconate, benzalkonium halides and cetylpyridinium chloride are preferred. Furthermore, sodium bicarbonate, sodium phenolsulfonate and zinc phenolsulfonate, the constituents of lime blossom oil, para-hydroxybenzoic acid methyl, ethyl and propyl esters, sodium benzoate, phenoxyethanol, triclosan (Irgasan® DP300) or triethyl citrate can be used.

Inhibitors of lipases, arylsulfatases (see WO 01/99376), β-glucuronidases (see WO 03/039505), 5-α-reductases and aminoacylases are preferred as enzyme-inhibiting substances.

Other antibacterial deodorant active ingredients are lantibiotics, glyco-glycerolipids, sphingolipids (ceramides), sterols and other active ingredients that are the Inhibit bacterial adhesion to the skin, z. As glycosidases, lipases, proteases, carbohydrates, di- and Oligosaccharidfettsäureester and alkylated mono- and oligosaccharides.

Also suitable as a deodorant active ingredient are water-soluble polyols selected from water-soluble diols, triols and higher-grade alcohols and also polyethylene glycols. Among the diols are C ₂ -Ci ₂ diols, in particular 1, 2-propylene glycol, butylene glycols such as. For example, 1, 2-butylene glycol, 1, 3-butylene glycol and 1, 4-butylene glycol, pentanediols, z. B. 1, 2-pentanediol, and hexanediols, for. B. 1, 6-hexanediol. Also preferred are glycerol and technical Oligoglyceringemische with an intrinsic degree of condensation of 1, 5 to 10 such as technical Diglyceringemische having a Diglycerine content of 40 to 50 wt .-% or triglycerol, further 1, 2,6-hexanetriol and polyethylene glycols (PEG) with a average molecular weight of 100 to 1000 daltons, for example PEG-400, PEG-600 or PEG-1000. Other suitable higher alcohols are the C ₄ , C ₅ and C ₆ monosaccharides and the corresponding sugar alcohols, eg. Mannitol or sorbitol.

Deodorant or antiperspirant sticks may be in gelled, anhydrous wax base and based on W / O emulsions and O / W emulsions. Gel sticks can be prepared on the basis of fatty acid soaps, dibenzylidenesorbitol, N-acylamino acid amides, 12-hydroxystearic acid and other gelling agents. Aerosol sprays, pump sprays, roll on applications and creams can be used as water in oil emulsion, oil in water emulsion, silicone oil in water emulsion, water in oil microemulsion, oil in water. Microemulsion, silicone oil-in-water microemulsion, anhydrous suspension, alcoholic and hydroalcoholic solution, aqueous gel and as an oil. All said compositions may be thickened, for example based on fatty acid soaps, dibenzylidenesorbitol, N-acylamino acid amides, 12-hydroxy stearic acid, carbomer and Carbopol type polyacrylates, polyacrylamides and polysaccharides, which may be chemically and / or physically modified. The emulsions and microemulsions may be transparent, translucent or opaque. Liquid and gelatin dosage forms of the compositions of the invention may contain thickening agents, e.g. For example, cellulose ethers, such as hydroxypropyl cellulose, hydroxyethyl cellulose and methyl hydroxypropyl cellulose, thickening polymers based on polyacrylates, which if desired can be crosslinked, for. As the Carbopol types or Pemulen ^® products, or based on polyacrylamides or sulfonic acid-containing polyacrylates, eg. B Sepigel ^® 305 or Simulgel® ^® EG, also inorganic thickeners such. B. Bentonite and Hectorite (Laponite ^®).

The compositions of the invention may contain other cosmetically and dermatologically active substances, such as anti-inflammatory substances, solids selected from silicic acids, eg. As Aerosil ^® types, silica gels, silica, clays, z. B. bentonite or kaolin, magnesium aluminum silicates, z. B. talc, boron nitride, titanium dioxide, which may optionally be coated, optionally modified starches and starch derivatives, cellulose and polymer powders, further plant extracts, protein hydrolysates, vitamins, perfume oils, sebostatics, anti-acne agents and keratolytics.

The compositions according to the invention, insofar as they are liquid, can be applied to flexible and absorbent carriers and offered as deodorant or antiperspirant wipes or sponges. As a flexible and absorbent carrier in the context of the invention, z. As carriers of textile fibers, collagen or polymeric foams. As textile fibers, both natural fibers such as cellulose (cotton, linen), silk, wool, regenerated cellulose (viscose, rayon), cellulose derivatives and synthetic fibers such as polyester, polyacrylonitrile, polyamide or Polyolefinfasem or mixtures of such fibers can be woven or unwoven. These fibers may be made into absorbent cotton pads, nonwovens or woven or knitted fabrics. Also flexible and absorbent polymeric foams, eg. As polyurethane foams and polyamide foams are suitable substrates. The substrate may have one, two, three and more than three layers, wherein the individual layers of the same or different materials can exist. Each substrate layer may have a homogeneous or an inhomogeneous structure with, for example, different zones of different densities.

Absorbent for the purposes of the invention are those support substrates which, at 20 ° C., can bind at least 10% by weight, based on the dry weight, of water adsorptively or capillary. Preferably, however, are those carriers which can bind at least 100 wt .-% water adsorptive and capillary.

The equipment of the carrier substrates is carried out in such a way that the absorbent, flexible carrier substrates, preferably from textile fibers, collagen or polymeric foams treated with the compositions according to the invention and optionally dried. In this case, the treatment (equipment) of the carrier substrates by any method, for. B. by spraying, dipping and squeezing, soaking or simply by injecting the composition of the invention into the carrier substrates.

Also preferred according to the invention is the dosage form as an aerosol, the cosmetic composition containing a propellant selected from propane, butane, isobutane, pentane, isopentane, dimethyl ether, fluorohydrocarbons and chlorofluorocarbons. Likewise, a compressed propellant such as air, nitrogen or carbon dioxide can be used. Likewise, mixtures of the stated blowing agents can be used.

In a preferred embodiment, the compositions according to the invention are in the form of a liquid or solid oil-in-water emulsion, water-in-oil emulsion, multiple emulsion, microemulsion, PIT emulsion or Pickering emulsion, a hydrogel, a lipogel, a single- or multi-phase solution, a foam, a powder or a mixture with at least one polymer suitable as a medical adhesive. The agents may also be in anhydrous form, such as an oil or a Balm, to be presented. Here, the carrier may be a vegetable or animal oil, a mineral oil, a synthetic oil or a mixture of such oils.

In a particular embodiment of the agents according to the invention, the agents are present as microemulsions. In the context of the invention, microemulsions are understood as meaning not only the thermodynamically stable microemulsions but also the so-called "PIT" emulsions, these systems being systems with the three components water, oil and emulsifier which are oil-in-water at room temperature. When these systems are heated, microemulsions are formed in a certain temperature range (referred to as the phase inversion temperature or "PIT") which, on further heating, convert to water-in-oil (W / O) emulsions O / W emulsions are formed, but which are also present at room temperature as microemulsions or as very finely divided emulsions having a mean particle diameter of less than 400 nm and in particular of about 100 to 300 nm having an average particle diameter of about 200 nm. Details concerning this "P IT emulsion en "eg the publication Angew. Chem. 97, 655 - 669 (1985).

The following examples are intended to illustrate the present invention without limiting it thereto.

embodiments

Example 1 :

From a pre-culture of Lactobacillus acidophilus (DSM20242) 50ml MRS medium (composition (g / l): Peptone from casein 10.0; meat extract 8.0; yeast extract 4.0; D (+) - glucose 20.0; dipotassium hydrogen phosphate 2.0 Tween ^® 80 1.0, di-ammonium hydrogen citrate 2.0, sodium acetate 5.0, magnesium sulfate 0.2, manganese sulfate 0.04) are inoculated with 2 × 10 ⁷ cells / ml and further cultured at 37 ° C. in a 100 ml Erlenmeyer flask with shaking (100 rpm). Further cultivation was carried out in the presence of 1% test substance (w / v or v / v) and for control without active ingredients. After 0, 8 and 24 h, the bacterial count was determined by plating on MRS agar (composition like MRS liquid medium but additionally with agar-agar 14 g / l). The comparison of the growth in the presence of the tested active ingredients (inulin and extracts of white tea, karkade (hibiscus), mallow and grape seeds) with the control shows a clear growth support by inulin and extracts of white tea after 8h and for the extracts of karkade and Grape seeds after 24h.

Extracts used: inulin (hot water root extract from Cichorium intybus, fibruline instant, cosucra), tea, white (dry extract on maltodextrin carrier, Cosmetochem), carcass (extract in 80% propylene glycol / water, Cosmetochem), grape seed (extract in 80% Propylene glycol / water, Cosmetochem)

Example 2:

Inhibition of hyphal formation of Candida albicans by farnesol

Overnight cultures of Candida albicans (SC5314) were grown ⁰ C until OD6oo = 1 in YPD medium (1% yeast extract, 2% peptone, 2% glucose) at 3O and after one wash in water again for one hour with shaking at 30 ⁰ C incubated. The cells were then seeded 1:10 in YPS Hyphen induction medium (1% yeast extract, 2% peptone, 5% horse serum). To evaluate the effect of Famesol on hyphae formation, 25mg / L Famesol was added to a YPS approach. The control was a culture in YPD medium. The batches were incubated for 80 min at 37 ° C with shaking. The formation of hyphae was determined every 20 minutes by microscopy by counting the proportion of germ-tube-carrying cells.

Example 3:

Influencing the growth of Lactobacillus acidophilus

farnesol

50 ml of MRS medium (composition (g / l): Peptone from casein 10.0; ^® 80 1.0, di-ammonium hydrogen citrate 2.0, sodium acetate 5.0, magnesium sulfate 0.2, manganese sulfate 0.04) are inoculated with 2 × 10 ⁷ cells / ml and further cultured at 37 ° C. in a 100 ml Erlenmeyer flask with shaking (100 rpm). Further cultivation was carried out in the presence of 1% inulin with and without the addition of 100 ppm Famesol. After 0, 8 and 24 h, the microbial count was determined by measuring the optical density at 620 nm (OD620) in the photometer. The results surprisingly show no influence on the growth of Lactobacillus acidophilus by the addition of Famesol.

example recipes

The information is given in accordance with the INCI nomenclature. Cleansing milk (in% by weight)

Mild detergent (in% by weight)

Eumulgin ^® HRE 40 0.6 0.6

Eucaror AGE-ET 2.0 2.0

1, 2-propylene glycol 10.0 10.0

Farnesol 0.005 0.015

Inulin 0.5 2.0

Carcass extract 2,0 0,5

Oil-in-water emulsions (in% by weight)

1st example series:

2nd example series:

4th example series:

3. Cleaning preparations (in% by weight)

1st example series:

5. Intimate wash solutions (% by weight)

1st example series:

2nd example series:

3rd example series:

List of ingredients used

Claims

claims

Use of a composition comprising a) at least one substance which is conducive to the growth of lactobacilli and / or bifidobacteria and b) at least one substance which causes a reduction of Candida adhesion as a prebiotic for the skin and mucosa in the genital area or intestinal area.

Use according to claim 1, characterized in that said at least one substance causing a reduction in Candida adhesion is a substance which reduces the adhesion of Candida to human skin.

3. Use according to claim 1, characterized in that the at least one substance which causes a reduction in Candida adhesion, is a substance which reduces the Hyphenbildung of Candida.

4. Use according to claim 1, characterized in that it is an antifungal substance in the at least one substance which causes a reduction in Candida adhesion.

5. Use according to one of the preceding claims, characterized in that the substance which causes a reduction in the Candida adhesion is selected from climbazole, Octopirox, their derivatives or mixtures thereof.

6. Use according to one of the preceding claims, characterized in that the substance which causes a reduction in Candida adhesion is selected from Dufstoffalkoholen, propolis, plant extracts, algae extracts, terpenes and derivatives of the substances mentioned and mixtures of these substances.

7. Use according to one of the preceding claims, characterized in that the substance which causes a reduction of the Candida adhesion is selected from carrier-bound perfume alcohols and / or terpenes.

8. Use according to claim 7, characterized in that the carrier-bound perfume alcohol and / or terpene is a silicic acid ester of the perfume alcohol and / or terpene.

9. Use according to claim 7, characterized in that it is the carrier is a cage molecule.

10. Use according to one of claims 6 to 9, characterized in that it is the terpene Famesol or a derivative thereof.

11.Use according to one of the preceding claims, characterized in that it is the at least one substance which is conducive to the growth of lactobacilli and / or bifidobacteria, is an oligozucker or an oligozucker-containing plant extract.

12. Use according to claim 11, characterized in that the oligosugar is inulin.

13. Use according to claim 11 or 12, characterized in that it is the plant extract containing oligozucker an inulin-containing plant extract selected from the group consisting of extracts of dahlia tubers, artichokes, Jerusalem artichoke tubers, chicory roots, dandelion roots and extracts of daisy family ( Asteraceae) or mixtures thereof.

Use according to any one of the preceding claims, characterized in that the at least one substance which is conducive to the growth of lactobacilli and / or bifidobacteria is a tea extract or an extract of the Vitaceae family.

15. Use according to claim 14, characterized in that the plant extract is an extract of white tea, carcass or grapes.

16. A composition comprising a) at least one substance which is conducive to the growth of lactobacilli and / or bifidobacteria, b) at least one substance which causes a reduction of Candida adhesion.

17. The composition according to claim 16, characterized in that it is a cosmetic or pharmaceutical composition.

18. Composition according to claim 16 or 17, characterized in that it is a topical skin treatment agent.

19. The composition according to any one of claims 16 to 18, characterized in that it is an intimate care product.

20. A composition according to any one of claims 16 to 19, characterized in that it is in a soap, a lotion, a powder, a syndet, a foam, a stick, an emulsion, a spray, a cream, a gel, a shampoo or a deodorant is included.

2 I.Zusammensetzung according to claim 16, characterized in that it is a food.