EP1764418A1 - Verfahren und Vorrichtung zur Behandlung biologischer Proben mittels Dielektrophorese - Google Patents

Verfahren und Vorrichtung zur Behandlung biologischer Proben mittels Dielektrophorese Download PDF

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Publication number
EP1764418A1
EP1764418A1 EP05108445A EP05108445A EP1764418A1 EP 1764418 A1 EP1764418 A1 EP 1764418A1 EP 05108445 A EP05108445 A EP 05108445A EP 05108445 A EP05108445 A EP 05108445A EP 1764418 A1 EP1764418 A1 EP 1764418A1
Authority
EP
European Patent Office
Prior art keywords
particles
electrode
trapping
electrodes
trapped
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP05108445A
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English (en)
French (fr)
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EP1764418B1 (de
Inventor
Mario Scurati
Torsten Mueller
Thomas Schnelle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Revvity Cellular Technologies GmbH
STMicroelectronics SRL
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Evotec Technologies GmbH
STMicroelectronics SRL
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Application filed by Evotec Technologies GmbH, STMicroelectronics SRL filed Critical Evotec Technologies GmbH
Priority to EP05108445A priority Critical patent/EP1764418B1/de
Priority to US11/531,679 priority patent/US7988841B2/en
Publication of EP1764418A1 publication Critical patent/EP1764418A1/de
Application granted granted Critical
Publication of EP1764418B1 publication Critical patent/EP1764418B1/de
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/026—Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]

Definitions

  • the passivation layer 9 has a plurality of openings 15 stretching between and partly on top of two contiguous electrodes 5, so that the passivation 9 does not cover the two facing halves of pairs of electrodes 5.
  • the target cells 16 are attracted to the electrode edges that are not covered by the passivation (at the openings 15).

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  • Engineering & Computer Science (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP05108445A 2005-09-14 2005-09-14 Verfahren und Vorrichtung zur Behandlung biologischer Proben mittels Dielektrophorese Active EP1764418B1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05108445A EP1764418B1 (de) 2005-09-14 2005-09-14 Verfahren und Vorrichtung zur Behandlung biologischer Proben mittels Dielektrophorese
US11/531,679 US7988841B2 (en) 2005-09-14 2006-09-13 Treatment of biological samples using dielectrophoresis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05108445A EP1764418B1 (de) 2005-09-14 2005-09-14 Verfahren und Vorrichtung zur Behandlung biologischer Proben mittels Dielektrophorese

Publications (2)

Publication Number Publication Date
EP1764418A1 true EP1764418A1 (de) 2007-03-21
EP1764418B1 EP1764418B1 (de) 2012-08-22

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EP05108445A Active EP1764418B1 (de) 2005-09-14 2005-09-14 Verfahren und Vorrichtung zur Behandlung biologischer Proben mittels Dielektrophorese

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US (1) US7988841B2 (de)
EP (1) EP1764418B1 (de)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007116406A1 (en) * 2006-04-10 2007-10-18 Technion Research & Development Foundation Ltd. Method and device for electrokinetic manipulation
WO2009037804A1 (ja) * 2007-09-18 2009-03-26 Panasonic Corporation 微粒子測定装置および微粒子測定方法
WO2009151407A2 (en) 2008-06-14 2009-12-17 Veredus Laboratories Pte Ltd Influenza sequences
KR100947334B1 (ko) 2008-01-30 2010-03-16 인제대학교 산학협력단 유전영동 미세분리기
CN101059526B (zh) * 2007-05-24 2011-04-20 上海交通大学 微通道中利用电热流驱动流体运动的方法
EP2350630A1 (de) * 2008-10-31 2011-08-03 Agency for Science, Technology and Research Vorrichtung und verfahren für den nachweis eines analyts aus einer probe
CN102395424A (zh) * 2009-02-20 2012-03-28 独立行政法人科学技术振兴机构 通过恒定电场传输微米级物体以及获得机械功
WO2013028058A1 (en) * 2011-08-24 2013-02-28 Mimos Berhad Apparatus for sorting particles by dielectrophoresis
EP2781906A3 (de) * 2013-03-19 2018-01-24 IMEC vzw Verfahren und Vorrichtung zur Identifizierung Zellen
WO2019078922A1 (en) * 2017-10-19 2019-04-25 Analog Devices, Inc. MEASURING IMPEDANCE IN A DIAGNOSTIC TEST
EP3906118A4 (de) * 2018-12-31 2022-10-12 Technion Research & Development Foundation Limited Vorrichtung und verfahren zum sortieren von zellen in einer biologischen probe

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US20090038938A1 (en) * 2007-05-10 2009-02-12 The Regents Of The University Of California Microfluidic central processing unit and microfluidic systems architecture
JP2011516867A (ja) * 2008-04-03 2011-05-26 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア 細胞、小胞、ナノ粒子およびバイオマーカーを分離および単離するためのエキソビボの多次元システム
GB0809486D0 (en) * 2008-05-23 2008-07-02 Iti Scotland Ltd Triple function elctrodes
DE102009028496A1 (de) * 2009-08-13 2011-02-17 Robert Bosch Gmbh Mikrofluidische Zelle
DE102009028493B4 (de) * 2009-08-13 2023-08-24 Robert Bosch Gmbh Mikrofluidische Zelle
US8524064B2 (en) * 2010-04-22 2013-09-03 Lawrence Livermore National Security, Llc Three dimensional microelectrode system for dielectrophoresis
US20130340806A1 (en) * 2011-01-27 2013-12-26 Hitachi Chemical Company, Ltd. Electrically conductive adhesive composition, connector and solar cell module
US9932635B2 (en) * 2011-05-24 2018-04-03 The Regents Of The University Of California Method for exosomal biomarker detection by electric field-induced release and measurement
JP6047159B2 (ja) * 2011-08-02 2016-12-21 東京エレクトロン株式会社 電場印加装置を用いて組織を構築するシステム及び方法
US9120105B2 (en) * 2011-10-31 2015-09-01 Monika Weber Electronic device for pathogen detection
US11198126B2 (en) 2011-10-31 2021-12-14 Fluid-Screen, Inc. Apparatus for pathogen detection
KR101356460B1 (ko) * 2012-02-08 2014-02-04 서울대학교산학협력단 입자 분리 장치 및 이를 이용하여 솔루션으로부터 입자를 분리하는 방법
US8932815B2 (en) 2012-04-16 2015-01-13 Biological Dynamics, Inc. Nucleic acid sample preparation
CA2870160C (en) 2012-04-16 2021-08-24 Biological Dynamics, Inc. Nucleic acid sample preparation
US9981273B2 (en) 2012-09-28 2018-05-29 The Board Of Trustees Of The Leland Stanford Junior University Negative dielectrophoresis for selective elution of immuno-bound particles
TWI472756B (zh) * 2013-12-11 2015-02-11 Nat Applied Res Laboratories A biochip device and a method of separating and concentrating particles in a fluid
WO2015157217A1 (en) 2014-04-08 2015-10-15 Biological Dynamics, Inc. Improved devices for separation of biological materials
US10081015B2 (en) 2015-07-12 2018-09-25 International Business Machines Corporation Trapping at least one microparticle
US9962714B2 (en) * 2015-07-12 2018-05-08 International Business Machines Corporation Microchannel, microfluidic chip and method for processing microparticles in a fluid flow
AU2017237187B2 (en) 2016-03-24 2022-12-08 Biological Dynamics, Inc. Disposable fluidic cartridge and components
SG11201808959QA (en) 2016-04-15 2018-11-29 Fluid Screen Inc Analyte detection methods and apparatus using dielectrophoresis and electroosmosis
US20180093271A1 (en) * 2016-09-30 2018-04-05 The University Of Tokyo Microdevice for Capturing Particles, and Method for Capturing, Concentrating, or Separating Particles Using the Same
US10413913B2 (en) 2017-02-15 2019-09-17 Tokyo Electron Limited Methods and systems for dielectrophoresis (DEP) separation
IL270445B1 (en) 2017-05-08 2024-02-01 Biological dynamics inc Methods and systems for processing information on tested material
EP3727693A4 (de) 2017-12-19 2021-08-25 Biological Dynamics, Inc. Verfahren und vorrichtungen zum nachweis mehrerer analyten aus einer biologischen probe
WO2019195196A1 (en) 2018-04-02 2019-10-10 Biological Dynamics, Inc. Dielectric materials
KR20210054017A (ko) 2018-10-01 2021-05-12 도쿄엘렉트론가부시키가이샤 기판 표면으로부터 이물질을 정전기적으로 제거하기 위한 장치 및 방법
US11460020B2 (en) * 2019-02-19 2022-10-04 MicroMED Co., Ltd. Micro-delivery device
EP4058778A4 (de) 2019-11-13 2023-12-27 Fluid-Screen, Inc. Verfahren und vorrichtung zum nachweis von bakterien in einer probe mittels dielektrophorese
EP4058055A4 (de) 2019-11-13 2023-12-13 Fluid-Screen, Inc. Vorrichtung und verfahren zur schnellen detektion, trennung, reinigung und quantifizierung verschiedener viren aus zellen, kulturmedien und anderen flüssigkeiten
KR20240015951A (ko) * 2022-07-28 2024-02-06 삼성전자주식회사 미세 입자 필터 장치, 미세 입자 필터 방법 및 이를 포함하는 세탁기

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US6071394A (en) * 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
US20020036142A1 (en) * 2000-06-14 2002-03-28 Peter Gascoyne Systems and methods for cell subpopulation analysis
US20020088712A1 (en) * 2001-01-09 2002-07-11 The Regents Of The University Of California Movement of particles using sequentially activated dielectrophoretic particle trapping
US20040011650A1 (en) * 2002-07-22 2004-01-22 Frederic Zenhausern Method and apparatus for manipulating polarizable analytes via dielectrophoresis
EP1403383A1 (de) * 2002-09-17 2004-03-31 STMicroelectronics S.r.l. Mikropumpe insbesondere für integrierte Vorrichtung für biologische Analysen

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CA2134477C (en) 1992-05-01 1999-07-06 Peter Wilding Analysis based on flow restriction
US6235471B1 (en) * 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
DE19815882A1 (de) * 1998-04-08 1999-10-14 Fuhr Guenther Verfahren und Vorrichtung zur Manipulierung von Mikropartikeln in Fluidströmungen
EP1089824B1 (de) * 1998-06-26 2003-11-05 Evotec OAI AG Elektrodenanordnung zur dielektrophoretischen partikelablenkung
US6783647B2 (en) * 2001-10-19 2004-08-31 Ut-Battelle, Llc Microfluidic systems and methods of transport and lysis of cells and analysis of cell lysate

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
US6071394A (en) * 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
US20020036142A1 (en) * 2000-06-14 2002-03-28 Peter Gascoyne Systems and methods for cell subpopulation analysis
US20020088712A1 (en) * 2001-01-09 2002-07-11 The Regents Of The University Of California Movement of particles using sequentially activated dielectrophoretic particle trapping
US20040011650A1 (en) * 2002-07-22 2004-01-22 Frederic Zenhausern Method and apparatus for manipulating polarizable analytes via dielectrophoresis
EP1403383A1 (de) * 2002-09-17 2004-03-31 STMicroelectronics S.r.l. Mikropumpe insbesondere für integrierte Vorrichtung für biologische Analysen

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007116406A1 (en) * 2006-04-10 2007-10-18 Technion Research & Development Foundation Ltd. Method and device for electrokinetic manipulation
CN101059526B (zh) * 2007-05-24 2011-04-20 上海交通大学 微通道中利用电热流驱动流体运动的方法
WO2009037804A1 (ja) * 2007-09-18 2009-03-26 Panasonic Corporation 微粒子測定装置および微粒子測定方法
JPWO2009037804A1 (ja) * 2007-09-18 2011-01-06 パナソニック株式会社 微粒子測定装置および微粒子測定方法
KR100947334B1 (ko) 2008-01-30 2010-03-16 인제대학교 산학협력단 유전영동 미세분리기
WO2009151407A2 (en) 2008-06-14 2009-12-17 Veredus Laboratories Pte Ltd Influenza sequences
EP2350630A4 (de) * 2008-10-31 2012-03-28 Agency Science Tech & Res Vorrichtung und verfahren für den nachweis eines analyts aus einer probe
EP2350630A1 (de) * 2008-10-31 2011-08-03 Agency for Science, Technology and Research Vorrichtung und verfahren für den nachweis eines analyts aus einer probe
CN102395424A (zh) * 2009-02-20 2012-03-28 独立行政法人科学技术振兴机构 通过恒定电场传输微米级物体以及获得机械功
CN102395424B (zh) * 2009-02-20 2014-04-23 独立行政法人科学技术振兴机构 通过恒定电场传输微米级物体以及获得机械功
US9126198B2 (en) 2009-02-20 2015-09-08 Japan Science And Technology Agency Transportation of micrometer-sized object and extraction of mechanical work by constant electric field
WO2013028058A1 (en) * 2011-08-24 2013-02-28 Mimos Berhad Apparatus for sorting particles by dielectrophoresis
EP2781906A3 (de) * 2013-03-19 2018-01-24 IMEC vzw Verfahren und Vorrichtung zur Identifizierung Zellen
WO2019078922A1 (en) * 2017-10-19 2019-04-25 Analog Devices, Inc. MEASURING IMPEDANCE IN A DIAGNOSTIC TEST
US11543402B2 (en) 2017-10-19 2023-01-03 Analog Devices, Inc. Impedance measurement in diagnostic testing
EP3906118A4 (de) * 2018-12-31 2022-10-12 Technion Research & Development Foundation Limited Vorrichtung und verfahren zum sortieren von zellen in einer biologischen probe

Also Published As

Publication number Publication date
EP1764418B1 (de) 2012-08-22
US20070125650A1 (en) 2007-06-07
US7988841B2 (en) 2011-08-02

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