EP1758922B8 - Peptide substance restoring function of respiratory organs - Google Patents

Peptide substance restoring function of respiratory organs Download PDF

Info

Publication number
EP1758922B8
EP1758922B8 EP04808997A EP04808997A EP1758922B8 EP 1758922 B8 EP1758922 B8 EP 1758922B8 EP 04808997 A EP04808997 A EP 04808997A EP 04808997 A EP04808997 A EP 04808997A EP 1758922 B8 EP1758922 B8 EP 1758922B8
Authority
EP
European Patent Office
Prior art keywords
respiratory organs
aspartyl
glutamyl
glu
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP04808997A
Other languages
German (de)
French (fr)
Other versions
EP1758922B1 (en
EP1758922A1 (en
Inventor
Vladimir Khatskelevich Khavinson
Galina Anatolievna Ryzhak
Evgeny Iosifovich Grigoriev
Irina Yurievna Ryadnova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Access Bioscience CJSC
Original Assignee
Access Bioscience CJSC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Access Bioscience CJSC filed Critical Access Bioscience CJSC
Publication of EP1758922A1 publication Critical patent/EP1758922A1/en
Application granted granted Critical
Publication of EP1758922B1 publication Critical patent/EP1758922B1/en
Publication of EP1758922B8 publication Critical patent/EP1758922B8/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention refers to the medicinal remedies for respiratory system diseases treatment and may be applied as a substance, capable of restoring respiratory organs functions and used for treatment of different forms of lung pathology. There is proposed a biologically active new tetrapeptide alanyl-glutamyl-aspartyl-leucine of the general formula Ala-Glu-Asp-Leu, capable of restoring respiratory organs function. There is proposed a pharmaceutical substance, containing as an active peptide agent an effective amount of tetrapeptide alanyl-glutamyl-aspartyl-leucine of the general formula Ala-Glu-Asp-Leu, which if used in the medical preparation contributes to the restoration of the respiratory organs function.
EP04808997A 2004-06-22 2004-12-07 Peptide substance restoring function of respiratory organs Not-in-force EP1758922B8 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2004118700/15A RU2255757C1 (en) 2004-06-22 2004-06-22 Peptide compound recovering function of respiratory organs
PCT/RU2004/000494 WO2006001729A1 (en) 2004-06-22 2004-12-07 Peptide substance restoring respiratory organs function

Publications (3)

Publication Number Publication Date
EP1758922A1 EP1758922A1 (en) 2007-03-07
EP1758922B1 EP1758922B1 (en) 2008-02-13
EP1758922B8 true EP1758922B8 (en) 2008-05-07

Family

ID=34960198

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04808997A Not-in-force EP1758922B8 (en) 2004-06-22 2004-12-07 Peptide substance restoring function of respiratory organs

Country Status (7)

Country Link
US (1) US7625870B2 (en)
EP (1) EP1758922B8 (en)
AT (1) ATE386046T1 (en)
DE (1) DE602004011842T2 (en)
ES (1) ES2302068T3 (en)
RU (1) RU2255757C1 (en)
WO (1) WO2006001729A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010124141A1 (en) * 2009-04-24 2010-10-28 Mpex Pharmaceuticals, Inc. Methods of treating a pulmonary bacterial infection using fluoro-quinolones
RU2667466C1 (en) * 2017-11-27 2018-09-19 Общество с ограниченной ответственностью "МЕДИНВЕСТ" Peptide compound, restoring function of respiratory bodies and inflammable immunomodulating action
RU2767532C1 (en) * 2021-05-27 2022-03-17 Общество с ограниченной ответственностью "ТЕРРАНОВА КАПИТАЛ" Peptide having bronchoprotective action, pharmaceutical composition based thereon and method for use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1681426A1 (en) 1989-07-20 1994-08-15 Г.М. Яковлев Method of preparing of substance recovering lung respiratory function
RU1681427C (en) 1989-09-11 1994-11-15 Яковлев Герман Михайлович Method of preparing of agent enhancing antibacterial resistivity of lung
RU2157233C1 (en) * 1999-05-11 2000-10-10 Санкт-Петербургская общественная организация "Институт биорегуляции и геронтологии" Tetrapeptide showing geroprotective activity, pharmacological agent based on thereof and method of its use

Also Published As

Publication number Publication date
RU2255757C1 (en) 2005-07-10
EP1758922B1 (en) 2008-02-13
ATE386046T1 (en) 2008-03-15
US7625870B2 (en) 2009-12-01
US20080274982A1 (en) 2008-11-06
DE602004011842D1 (en) 2008-03-27
ES2302068T3 (en) 2008-07-01
DE602004011842T2 (en) 2009-02-05
EP1758922A1 (en) 2007-03-07
WO2006001729A1 (en) 2006-01-05

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