Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/005—Preparations for sensitive skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/007—Preparations for dry skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/08—Anti-ageing preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q5/00—Preparations for care of the hair
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
  • A61K2800/52—Stabilizers
  • A61K2800/522—Antioxidants; Radical scavengers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
  • A61Q1/02—Preparations containing skin colorants, e.g. pigments

Definitions

• the present invention relates to cosmetic and hygiene products intended to be used in cosmetology for maintaining and improving the health condition by balancing and ameliorating the cosmetological status, to a process for preparing and using the same and to a method of ameliorating the cosmetological cutaneous status.
• cosmetic and hygiene preparations used for preventing and treating the skin diseases, including maintenance and beauty products that comprise water with a deuterium content ranging from 111 to 135 ppm.
• the cosmetic products described in the mentioned patent exhibit, due to the low deuterium content, an action of preventing the cancerous skin diseases by lowering the deuterium concentration in the skin.
• the products obtained this way may be used for preventing and treating the tumoural diseases, for slowing down the aging processes and for treating other skin diseases, such as the psoriasis, warts, excessive skin pigmentation, skin tuberculosis and also for preventing the ocurrence of wrinkles.
• the products obtained this way may be used for preventing and treating the tumoural diseases, for slowing down the aging processes and for treating other skin diseases, such as the psoriasis, warts, excessive skin pigmentation, skin tuberculosis and also for preventing the ocurrence of wrinkles.
• the problem solved by the present invention is to make products for improving the cutaneous, energetic and constitutional cell metabolism, for improving the hydric balance at the cell level and for having an immunomodulating and cell proliferation control activity, with wrinkle preventing and cutaneous aging control effect.
• ASD deuterium-depleted water
• the cosmetic and hygiene products preferably comprise 40 ... 90%, and more preferably between 40 ... 80% of deuterium-depleted water with a deuterium content preferably in the range of 20 ... 30 ppm.
• the cosmetic and hygiene products claimed by the invention are preferably formulated as lotions, spays, creams, emulsions, gels, masks, mouth care water, dentifrice, make-ups, soaps, shampoos, balsams, hair sprays etc.
• the cosmetic and hygiene products claimed by the invention possibly contain, besides the deuterium-depleted water, another active component that can be selected from: vitamins, vegetable origin components, sexual hormones, phyto-hormones, bee products, extracts from see algae and sapropelic muds, animal origin components, inorganic components and medicaments, such as antibiotics and antimycotics.
• another active component that can be selected from: vitamins, vegetable origin components, sexual hormones, phyto-hormones, bee products, extracts from see algae and sapropelic muds, animal origin components, inorganic components and medicaments, such as antibiotics and antimycotics.
• the process for obtaining a cosmetic and hygiene product claimed by the invention consists in that in a first step there is obtained the basic composition by mixing the fatty components, in hot conditions preferably at 80°C, in the presence of an emulsifier, for minimum 10 minutes, up to completely melting, and homogenizing the resulting mixture, followed by gradually pouring therein, while vigorously stirring, a homogenous mixture obtained in a second step, in hot conditions preferably at 80°C, from deuterium - depleted water having a deuterium content in the range of 2 ...
• the process of using the cosmetic and hygiene products with a view to maintaining the cosmetological status consists in preparing the human body surface of interest by treating, for 5 ... 12 days, 2 ... 3 times a day, daily, preferably by the application as compresses or by spraying with ASD having a deuterium content of 40 ...60 ppm, followed by the application of any one of the products, and between two successive applications of the product, 10 ...
• the method of ameliorating the cutaneous cosmetological status consists in that the product defined in any one of the claims 1 ... 5 is applied on the area of interest, 2 - 3 times a day as: compresses kept for 10 ...
• the cosmetic and hygiene products claimed by the invention have the following advantages: - revitalize the energetic and constitutional skin cell metabolism by improving the use of glucose and fats; - rapidly improve the hydric balance by the more rapid absorption and in a bigger quantity of the water in the cell, the deuterium - depleted water being hypotonic, thereby exerting an excellent hydrating effect; - have an immunomodulating action and consequently they increase the topical defense power; - control the cell proliferation that has consequences on the epidermis where they influence the cell regeneration and the collagen and elastic fibres synthesis; - allow a very good skin and mucous membranes respiration; - the amelioration of the cosmetological status is produced in a relatively short time and the reached level is maintained for a relatively long time.
• Vitamins selected from the group of vitamins A, B, C, D, E, F, H, Biotin, D-Panthenol Vegetable origin components such as: - plant extracts preferably from wild camomile, watercress, arnica, garden sage, stinging nettle, aloe, blackwort, gingo, ginseng, rose, camomile, orange flowers, melissa, licorice, country mallow, chestnut, mint, edelweiss etc; - extracts from trees and/or parts of the trees, such as preferably chlorophyl; extract from chestnut tree, ivy, lime -tree, dwarf palm tree, silky willow, pine apple, henna, birch, hazel tree, coffee, white cedar etc; - extracts or fruit or vegetable juices such as preferably apricots, strawberries, grape-fruit, grapes
• Animal origin components such as: - oils and fats preferably cetaceum, mink oil, polar fox fat etc; - protein extracts from milk, lipids from milk - amino acids, preferably alanin, creatine, glycine, cysteic acid, aspartic acid, glycocol, carnitine, polymannuroic acid etc; - matriceal components such as collagen, glycoseaminoglycans, glycoproteins, mucopolysaccharides, saccharides, hyaluronic acid and derivatives thereof, gluten hydrolysates, elastin etc; - extracts from placenta, thymus etc; - phospholipids, preferably sericine, lecitin etc; Inorganic compounds such as: - ions of metals or non-metals, preferably ions of S, CI, K, Ca, Zn, Hg; - oxides, bases, acids, salts, preferably hydrogen peroxide, titanium oxide, zinc oxide, sodium perbor
• Medicaments such as antibiotics and antimycotics, such as ketoconazole, cyclopiroxolamine, zinc pyrition, chloromethyl/methylisothiazolone, trichlorocarbanilide etc, and others such as silanols, hyaluronic acid and the derivatives thereof, caviar extract, diamond powder, dimeticon copolyol, polycarbinol, trichlorocarbanilide etc.
• cosmetological excipients and additives such as propylene glycol, glycerin, cetol, cetyl stearic alcohols, glycerin monostearate, stearic acid, linoleic acid, caprilic/capric triglycerides, isopropylmyristate, sodium lauryl sulphate, sodium lauryl ether sulphate, cocos oil, white mineral oil, sodium polyacrylate, low density polyethylene, polycarbinol, trichlorocarbanilide, dimeticon copolyol; stabilizers such as preferably disodium cocoamfodiacetate etc; emulsifiers such as preferably 12 cetyl stearyl alcohol, 20 cetyl stearyl alcohol, sodium polyacrylate, vinylpyrolidone/styrene copolymer etc; thickening agents such as preferably carboxyvinyl polymer etc; pearling agents; surfactants such as co
• the cosmetic and hygiene products according to the invention Upon the industrial application of the cosmetic and hygiene products according to the invention, these products exhibited good spreading characteristics, in conditions in which the transcutaneous penetration is rapid and very good, in this respect allowing them to be included in the class of "vanishing" products, and at the same time they are very stable in time. It has been ascertained that the cosmetic and hygiene products claimed by the invention exhibit a surprising effect with regard to the tolerance and response to the application, these being suitable for a sensitive skin, in this situation not having been ascertained either the undesirable side effects to manifest immediately or after long-time administration. Within the clinical tests performed, it has been ascertained that the medical cosmetic products prepared according to the invention, preferably comprising 40 ... 90% and more preferably 40 ...
• 80% deuterium-depleted water with a deuterium content preferably in the range of 20 to 30 ppm have outstanding therapeutic effects, beneficial for a large range of dermatological affections, such as: - day cream for normal and dry face skin and as day cream for sensitive face skin, applied 2 - 3 times a day, in a thin film, while gently massaging the area of interest, after 5 -10 days of systemic use, by the effects of ameliorating the own ASD metabolic performances and by the special hydrating, emollient and calming effects, contributed to ameliorating the clinical status in over 85% of the users.
• dermatological affections such as: - day cream for normal and dry face skin and as day cream for sensitive face skin, applied 2 - 3 times a day, in a thin film, while gently massaging the area of interest, after 5 -10 days of systemic use, by the effects of ameliorating the own ASD metabolic performances and by the special hydrating, emollient and calming effects, contributed to ameliorating the clinical status in over 85% of the
• the amelioration expressed in percentage relative to untreated witness subjects is in the range of 45 to 60%, in the case of the following affections: face eczemas, allergic contact dermites, irritative dermatites as well as essential xerodermias and xerodermias secondary to PUVA phototherapy or to therapy with aromatic retinoids for acnea, psoriasis, ichthyosis ; - body creams, hand creams and foot creams, after the application 2 - 3 times a day, in a richer film, with medium intensity massaging, demonstrated important therapeutic effects in over 95% of the users.
• the amelioration expressed in percentage relative to the untreated witness subjects being in the range of 65 to 75% in the case of the following affections: atopic dermatitis, chronical eczemas, cutaneous dryness due to aging, xerodermias secondary to phototherapy for psoriasis, eczemas, cutaneous lymphomas, vitiligo; - gel-creams intended for the scaled skin, after the application at least twice a day, in a rich film, possibly on the lesions located at elbows, knees, forearms, shanks etc, with thick scales as the ones caused by psoriasis, once a day under an occlusive dressing kept for 30 - 60 minutes, exhibited important curative effects in the treatment of psoriasis, xerodemias caused by aging, ichthyosis, causing important amelioration in over 85 - 95% of the users.
• the amelioration expressed in percentage relative to the untreated witness subjects being in the interval from 55 to 70%, in case of the mentioned affections; - creams intended for the face care and the ones intended to the body, hand and foot care, applied in a thick film, at least twice a day, of which at least once a day under occlusive dressing kept for one hour, determined ameliorations of over 90% of the users.
• the amelioration expressed in percentage relative to the untreated witness subjects is in the range from 55 to 75% in the case of the following affections: horny and cellular cutaneous productions with benign character (viral warts, viral papilloma, seborrheic warts etc), precancerous character (actinic keratoses etc) or malign character (basocellular and spinocellular epitelioma).
• benign character viral warts, viral papilloma, seborrheic warts etc
• precancerous character actinic keratoses etc
• malign character basic and spinocellular epitelioma
• the fundamental principle of using ASD is to progressively and slowly decrease the deuterium concentration in the body up to an as low as possible minimum value and for periods of time sufficiently long for obtaining the anticipated biological effects, but sufficiently short to prevent the organism adaptation to a certain concentration, followed by the slow increase of the deuterium concentration in the body liquids (the principle of the "harmonics stress").
• ASD may be associated with radiotherapy and anti-neoplastic chemotherapy diminishing the side effects thereof, as well as with other therapies for the basic disease or intercurrent sufferings that may occur during the use of ASD, but without any connection to ASD.
• the cell proliferation control mechanisms are achieved by the intervention at the "signalling" level by blocking the production of the primordial biochemical signal necessary for triggering the cell division, said signal being represented by an optimal report between the intracellular concentrations of deuterium and hydrogen.
• ASD reduces or concomitantly blocks the oncogenous genes expression.
• the modification of the D/H ratio affects the enzymes regulating the cell divisions (kinase + phosphatase).
• Example 1 CREAM FOR SCALED SKIN
• a vessel provided with stirring and heating jacket, previously washed with water and detergent, rinsed with distilled water and sterilized before use, by exposition to UV radiation for 30 minutes, there are introduced the components in the order and amounts mentioned in the table below and they are stirred, at a temperature of 40 ° C, for about 15 minutes.
• the gel-cream obtained is applied twice a day, while gently massaging, on the areas of interest, and 3 - 7 days after the application the skin becomes smooth, flexible, with marked reduction up to the disappearance of scales.
• the effect was more rapid and persistent in time when concomitantly with the cream application there was taken daily 1500 ml of water obtained by diluting 1 part of ASD with a deuterium content of 20 ... 30 ppm with 2 parts of still water or carbonated mineral water, divided into 6 - 8 portions, each of 150 - 200 ml.
• Step I Isopropyl myristate 6.0 Medicinal paraffin 5.0 Emulgin-type natural emulsifier 4.0 Cetol 1.5 ASD with 25 ⁇ 5 ppm 23.0 p ll Propylene glycol 5.0 Glycerin 5.0 Preservative 1.0 p ill Triglycerides of capric/caprilic acid 4.0 Solar protection factors 2.9 Jojoba oil 2.0 Olive oil 2.0 Grape-seed oil 0.5 Vitamin E 0.5 p lV ASD with a deuterium content of 25 ⁇ 5 ppm 22.2 Aloe vera extract 1.0 Hydrating agents 3.0 Hydrolyzed collagen 0.5 Alantoin 0.5% 0.1 Emulsifier 0.7 Perfuming agent 0.1
• Step I In order to obtain the day cream for dry and normal face skin, the following process steps have to be performed: Step I. In a vessel provided with stirring and heating jacket, clean, previously washed with water and detergent, rinsed with distilled water and sterilized before use by exposing to UV radiation for 30 minutes, there are introduced the components, in the amounts mentioned in the table, in the following order: glycerol monostearate, isopropylmyristate, medicinal paraffin, Emulgin-type natural emulsifier, cetol, and the vessel is heated on a water bath, so that the temperature inside should be of 80°C and it is stirred for minimum 10 minutes, up to the complete melting and homogenizing.
• Step II In another vessel, similarto the above-mentioned one, clean, washed, dried and sterilized, there are introduced, while stirring, the following components: ASD in the amount mentioned in the table above, propylene glycol, glycerin, preservative, and the vessel is heated, while stirring, at a temperature of 80°C inside the vessel, and the stirring is continued up to homogenization. A 10% NaOH solution is added up to a pH of 5.5. The resulting mixture is poured in a thin jet over the mixture obtained in step I, at 80°C, while vigorously stirring, said stirring continuing for minimum 10 minutes up to the complete emulsifying. The emulsion obtained this way is let to cool, while stirring, up to the temperature of 40°C.
• Step III In a vessel provided with stirring and heating jacket, clean, dry and sterilized, there are introduced the oily components in the amounts indicated in the table and in the following order: triglycerides of capric/caprilic acid, solar protection factor, jojoba oil, olive oil, grape-seed oil, Vitamin E. While adding the components, the temperature in the vessel is raised and maintained at 40°C and the homogenization is performed at this temperature. The resulting mixture is maintained at 40°C.
• Step IV In another vessel provided with stirring and heating jacket, clean, dry and sterilized, there are added the following components in order: ASD, alantoin, dimethylsilanol hyaluronate, aloe vera extract, hydrating agent and hydrolyzed collagen.
• ASD alantoin
• dimethylsilanol hyaluronate dimethylsilanol hyaluronate
• aloe vera extract hydrating agent and hydrolyzed collagen.
• the mixture is heated at 40°C and stirred.
• 10% NaOH solution is added up to a mixture pH of 5.5.
• emulsifier is added, there being obtained an emulsion to which there is added, in a thin jet, the mixture obtained in Step III, while stirring.
• the emulsion obtained this way is added to the one resulting by mixing the steps I and II, followed by homogenizing, then dosing in the desired packaging.
• the day cream for normal and dry face skin has the following characteristics: a) organoleptic properties: 1. Aspect: creamy, unctuous, homogenous mass 2. Colour: white with slightly yellow hue 3. Smell: pleasant, depending on the perfuming agent employed b) physical-chemical properties: 1. Oil-in-water - type emulsion 2. Water and volatile substances %: 63.3% 3. Total fatty substances: 35.8% 4. Peroxide index meq/kg 0.38 5. Product pH 5.5 c) microbiological properties: 1 - NTG/ml ⁇ 100 2 - E.coli/ml absent 3. Staphylococcus coagulazo+/ml absent 4. Ps Aeruginosa/ml absent 5.
• the day cream thus obtained may be applied twice a day, in the morning and in the evening, or whenever necessary, on the areas of interest.
• the effect upon the face skin is spectacular, making the same velvet like and energizing and giving the same a healthy shine, concomitantly having excellent hydrating, emollient, and antioxidant properties, preventing the occurrence of wrinkles, giving a flexible and silky aspect to the face skin. It blocks the destructive action of the free radicals, by protecting the skin against the oxidative stress and premature aging, by increasing the face skin resistance to the aggression by the smog, ultraviolet radiation and pollutants.
• the cream exerts a beneficial effect on vergetures, protects the face skin against the aggressive action of ultraviolet radiations A and B and ensures the functional recovery of the healthy physiological conditions of the face skin.
• the cream exhibits very good spreading properties; it has a rapid and very good transcutaneous penetration, being included in the "vanishing" class products; it allows a better respiration of the skin and of the mucous membranes; it increases the topical defense power by the immunomodulating effect.

Applications Claiming Priority (2)

Publications (1)

Family

ID=34748267

Family Applications (1)

Country Status (3)

Cited By (1)

Families Citing this family (10)

Family Cites Families (3)

• 2003
  • 2003-05-23 RO ROA200300452A patent/RO120171B1/ro unknown
• 2004
  • 2004-04-02 WO PCT/RO2004/000007 patent/WO2005065631A2/en active Application Filing
  • 2004-04-02 EP EP04821021A patent/EP1670430A2/de not_active Withdrawn

Non-Patent Citations (1)

Also Published As

Similar Documents

Legal Events