EP1663176A1 - Cataplasme medical a teneur en huiles essentielles pour traiter des maladies dues a un refroidissement, et procede de preparation dudit cataplasme - Google Patents

Cataplasme medical a teneur en huiles essentielles pour traiter des maladies dues a un refroidissement, et procede de preparation dudit cataplasme

Info

Publication number
EP1663176A1
EP1663176A1 EP04764983A EP04764983A EP1663176A1 EP 1663176 A1 EP1663176 A1 EP 1663176A1 EP 04764983 A EP04764983 A EP 04764983A EP 04764983 A EP04764983 A EP 04764983A EP 1663176 A1 EP1663176 A1 EP 1663176A1
Authority
EP
European Patent Office
Prior art keywords
oil
weight
skin patch
polymer
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04764983A
Other languages
German (de)
English (en)
Inventor
Frank Theobald
Wolfgang Laux
René Eifler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Publication of EP1663176A1 publication Critical patent/EP1663176A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
    • A61F13/0253—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the adhesive material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00187—Wound bandages insulating; warmth or cold applying
    • A61F2013/00191—Wound bandages insulating; warmth or cold applying cooled by evaporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00655—Plasters adhesive
    • A61F2013/00659—Plasters adhesive polymeric base
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants

Definitions

  • the invention relates to medical skin plasters which enable the release of essential oils and are suitable for the treatment of colds.
  • the invention further relates to production methods by means of which such plasters can be obtained, and the use of these plasters for the treatment of colds.
  • ointment preparations are on the Available on the market, which contain essential oils and can be massaged into the chest area, whereupon the essential oils are released due to the evaporation caused by the body heat and can be inhaled through the mouth and nose.
  • the disadvantage here is that ointments are semi-solid, open preparations that are to be applied directly to the patient's skin. Through sweating, for example as a result of fever, these semi-solid ointment preparations are gradually washed off the skin or absorbed by the clothing and thereby lose their effectiveness.
  • Hydrophobic ointment preparations are more resistant to sweat and water, but they cause an occlusion effect, which can increase the already high body temperature at the application site. Likewise, applying an open, semi-solid preparation to the skin can subsequently contaminate the patient's clothing.
  • US Pat. No. 6,090,403 describes formulations in which essential oils are contained in a hydrophilic, pressure-sensitive adhesive preparation which is applied to a vapor-permeable solid carrier.
  • these preparations have a strong increase in viscosity within a short time after their preparation, so that further processing (for example coating) is no longer possible.
  • the maximum pot life ie the processing time after preparation of the preparation until the viscosity increases, is only about 1 to 2 hours.
  • the invention was therefore based on the object of providing medicinal preparations which enable the supply of essential oils for the treatment of colds and in which the disadvantages mentioned above do not occur or are in any case considerably reduced.
  • the skin plasters according to the invention have a gas and water vapor permeable backing layer and an associated hydrophilic polymer matrix with pressure-sensitive adhesive properties.
  • This polymer matrix contains:
  • At least one adsorbing substance and / or at least one emulsifying substance, at least one pressure-sensitive adhesive polymer are at least one adsorbing substance and / or at least one emulsifying substance, at least one pressure-sensitive adhesive polymer.
  • the water content of the matrix is less than 5% by weight, preferably less than 1% by weight.
  • the medical skin plasters of the present invention are hydrophilic, topical systems which are suitable for delivering essential oils and for treating treatment of colds are provided.
  • the essential oils are released from the polymer matrix of the patch as a result of body heat and escape as vapors through the gas and water vapor permeable back layer into the ambient air, and are then inhaled through the patient's mouth and nose.
  • the essential oils are incorporated in a hydrophilic, self-adhesive matrix, which serves as a reservoir for these volatile oils and which, when applied to the skin, is sealed off from the outside by the mentioned backing layer, so that clothing can be prevented from becoming dirty. Due to the hydrophilic character and the gas and water vapor permeable back layer, these plasters are well tolerated by the skin and an occlusion effect is avoided.
  • the essential oil (s) contained in the hydrophilic polymer matrix is / are preferably selected from the group consisting of eucalyptol (cineol), menthol, thymol, boronol, bisabolol, mint oil, peppermint oil, spearmint oil, Eucalyptus oil, camphor, turpentine oil, pine oil, anise oil, fennel oil, thyme oil, rosemary oil, chamomile oil and clove oil. Combinations of the substances or mixtures of substances mentioned are also possible; A combination of camphor, menthol and pine oil is particularly preferred.
  • the total proportion of the essential oil (s) is preferably 5 to 25% by weight, particularly preferably in the range of 10 to 20% by weight, based in each case on the polymer matrix.
  • the medical skin plasters according to the invention are distinguished by the fact that they contain at least one hydrophilic polymer which, due to the production process, is in the non-swollen state or is only swollen to a very small extent.
  • it is essential Significance that the water content of the hydrophilic matrix during production and also in the end product is less than 5% by weight, preferably less than 1% by weight.
  • the use of solvents which would lead to swelling of the hydrophilic polymers must be largely avoided during production.
  • the formulations according to the invention are able to absorb very large amounts of moisture or water during the application period without losing their structural integrity and falling off the application site.
  • the proportion of the hydrophilic polymer (s) is preferably in the range from 15 to 50% by weight, particularly preferably in the range from 20 to 40% by weight, based in each case on the matrix.
  • Suitable hydrophilic polymers are in principle those which have good swelling properties, are compatible with essential oils and are skin-friendly.
  • the hydrophilic polymer (s) is / are preferably selected from the group consisting of the cellulose derivatives, in particular carboxymethyl cellulose, carboxypropyl cellulose and polyvinyl alcohols, polyvinyl pyrrolidone, polyacrylic acid, polyacrylamide, polyethylene glycols, alginates, tragacanth, gums, includes in particular karaya gum, acacia gum, guar gum and xanthan, carrageenan, bentonite, starch and starch derivatives, it also being possible to use combinations of the abovementioned polymers.
  • the cellulose derivatives in particular carboxymethyl cellulose, carboxypropyl cellulose and polyvinyl alcohols, polyvinyl pyrrolidone, polyacrylic acid, polyacrylamide, polyethylene glycols, alginates, tragacanth, gums, includes in particular karaya gum, acacia gum, guar gum and xanthan, carrageenan, bentonite,
  • Another advantage of the topical systems for delivering essential oils according to the invention is that they have a cooling effect on the skin, since the evaporation of water and the essential oils above the water vapor-permeable backing layer (backing layer) results in a cooling effect due to the evaporation cold the skin comes.
  • Foil materials, fabrics (eg made of polyester) or textile materials which have these permeability properties can be used as the gas and water vapor permeable backing layer.
  • open-pore plastic foams eg polyurethane foam, polyethylene foam, plastic films made permeable by mechanical treatment, eg perforated polyethylene, polyethylene terephthalate, PVC films
  • the skin plasters according to the invention are further characterized in that they contain at least one adsorbing substance and / or at least one emulsifying substance.
  • Substances from the group which include cyclodextrin and cyclodextrin derivatives, silica and their derivatives (for example highly disperse silicon dioxide, diatomaceous earth) and medical charcoal are particularly suitable as adsorbing substances.
  • the following substances and groups of substances, individually or in combination, are particularly suitable as emulsifying substances: sodium palmitate, sodium stearate, triethanolamino stearate, sodium lauryl sulfate, gum arabic, alkonium bromide, benzalkonium bromide, cetylpryirdinium chloride, cetyl alcohol, branched fatty alcohol, fatty alcohol Partial fatty acids of polyhydric alcohols, partial fatty acid esters of sorbitan, partial fatty acid esters of polyoxyethylene sorbane, sorbitol ethers of polyoxyethylene, fatty acid esters of polyoxyethylene, fatty alcohol ether of polyoxyethylene, fatty acid ester of sucrose, fatty acid ester of polyglycerol, lecithin, complex emulsifiers such as.
  • other emulsifiers known to those skilled in the art can also be used.
  • the total proportion of the emulsifying substance (s) and / or the adsorbing substance (s) is preferably in the range from 0.1 to 40% by weight, particularly preferably in the range from 1 to 30 % By weight, and in particular in the range from 5 to 20% by weight, in each case based on the polymer matrix.
  • the hydrophilic matrix of the skin plasters according to the invention has adhesive properties; for this purpose the matrix contains at least one pressure-sensitive adhesive polymer or a combination of two or more such polymers.
  • Pressure-sensitive adhesive polymers are understood in principle to mean those polymers which are contained in pressure-sensitive adhesive formulations and which are suitable for use on the skin.
  • polymers and combinations of polymers from the following groups are suitable for this purpose: polyacrylates, polymethacrylates, polydimethylsiloxanes, polyvinyl acetate, polyisobutenes, polyisobutylenes, S-I-S block copolymers, polymerpenes, ethylene-vinyl acetate copolymers, rubber and synthetic rubbers.
  • the proportion of the pressure-sensitive adhesive polymer (s) is preferably 5 to 60% by weight, particularly preferably 5 to 40% by weight, in each case based on the polymer matrix.
  • the pressure-sensitive adhesive polymer (s) are in the crosslinked state; the crosslinking can be carried out in a manner known to the person skilled in the art, e.g. B. by chemical means (Al-acetylacetonate or Ti-Ace- tylacetonate, in the case of polyacrylates) or by means of radiation.
  • the crosslinking can be carried out in a manner known to the person skilled in the art, e.g. B. by chemical means (Al-acetylacetonate or Ti-Ace- tylacetonate, in the case of polyacrylates) or by means of radiation.
  • the hydrophilic matrix containing essential oils can additionally contain further formulation auxiliaries, preferably humectants (for example anhydrous glycol, propylene glycol or other polyhydric alcohols) or anti-foaming agents.
  • auxiliaries for example anhydrous glycol, propylene glycol or other polyhydric alcohols
  • the proportion of these auxiliaries can be 1 to 50% by weight, in particular 5 to 30% by weight.
  • the hydrophilic matrix on the skin contact side is covered with a removable protective film after production and during storage.
  • a removable protective film for example, polyester or other skin-compatible plastics, such as. B. polyvinyl chloride, ethylene vinyl acetate, vinyl acetate, polyethylene, polypropylene, cellulose derivatives, these films by suitable surface treatment such. B. Siliconization are removable.
  • the skin patches according to the invention are preferably sealed in gas and water vapor tight packaging.
  • the present invention further comprises methods for the production of medical skin plasters which have a hydrophilic, pressure-sensitive adhesive polymer matrix containing at least one essential oil and are suitable for the treatment of colds, in particular for the production of skin plasters of the type described above
  • Methods include the following steps: a) First, a coating composition is produced by mixing the following components, and optionally further optional components, with one another: at least one essential oil, at least one hydrophilic polymer, at least one pressure-sensitive adhesive polymer in a non-aqueous solvent,
  • the water content of the coating composition should be less than 5% by weight, preferably less than 1% by weight. It is thereby achieved that the hydrophilic polymer is not or at least only partially swelled during production.
  • the weight per unit area is preferably 20 to 400 g / m 2 (after drying).
  • part of the essential oil (s) is also evaporated; this must be taken into account by a corresponding surcharge in the recipe.
  • non-aqueous solvents examples include ethyl acetate, n-heptane, 2-propanol and ethanol. or mixtures thereof are used; these solvents are particularly suitable for polyacrylate pressure sensitive adhesives and silicone pressure sensitive adhesives.
  • suitable solvents depends primarily on the adhesive polymer (s); further suitable solvents are known to the person skilled in the art.
  • Step (a), or steps (a) and (b), are carried out with cooling, preferably at temperatures below 15 ° C., in particular at temperatures below 10 ° C. It has been shown that an undesirable increase in viscosity (due to swelling of the hydrophilic polymers) and a thickening of the coating compositions can also be caused due to the heat input during mixing and homogenization.
  • the processes according to the invention are distinguished in that the coating composition prepared in step (a) remains processable over a period of at least 3 h, preferably at least 5 h, particularly preferably over a period of at least 8 h after its production. In this way it is possible to produce larger batches and to process them into plasters before the viscosity increases and processing becomes impossible.
  • hydrophilic polymer matrix hydrophilic polymers, pressure-sensitive polymers, adsorbing substances, emulsifying substances, essential oils, additional auxiliaries
  • the coating composition contains the following components:
  • hydrophilic polymer preferably karaya gum
  • emulsifying substance preferably Tween ® 80, -. 0.5 to 10 wt -s antifoam agent. - 5 to 20% by weight of essential oil (s), preferably a combination of camphor, menthol and pine oil, the sum of the proportions of the individual components always giving 100% by weight.
  • essential oil preferably a combination of camphor, menthol and pine oil
  • the coating composition contains the following components:
  • adsorbing substance preferably a combination of silica and hydroxypropyl-beta-cyclodextrin,
  • -9s hydrophilic polymer preferably karaya gum
  • essential oil preferably a combination of camphor, menthol and pine oil, the sum of the proportions of the individual components always giving 100 wt. -9s.
  • Durotak ® 387-2054 polyacrylate pressure sensitive adhesive; National Starch and Chemical Co.
  • the information on the adhesive liver used relates to the pure solids content of the pressure sensitive adhesive present in solution.
  • the skin plasters according to the invention are advantageously suitable for use in methods for the treatment of colds.
  • a skin patch or a skin patch which has been produced by a method described above, is stuck onto the skin of the diseased person in the area of the chest, back, forehead, neck or neck.
  • This enables a continuous release of the essential oils through evaporation, as well as the subsequent absorption of the evaporated essential oils through the person's nose or mouth by inhalation.
  • these plasters have a cooling effect on the skin due to the evaporative cold.
  • the patch is left on the application site for a certain period of time, preferably 1 to 24 hours, after which it is removed and, if necessary, replaced by a new patch.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)

Abstract

Cataplasme médical pour traiter des maladies dues à un refroidissement par libération d'huiles essentielles par évaporation. Ledit cataplasme possède une couche arrière perméable aux gaz et à la vapeur d'eau et une matrice polymère hydrophile et adhésive reliée à la couche arrière. La matrice contient au moins une huile essentielle, au moins un polymère hydrophile, au moins un principe à action d'adsorption et / ou au moins une substance à action émulsifiante et au moins un polymère adhésif, la teneur en eau de la matrice étant inférieure à 5 % en poids, et de préférence inférieure à 1 % en poids.
EP04764983A 2003-09-11 2004-09-09 Cataplasme medical a teneur en huiles essentielles pour traiter des maladies dues a un refroidissement, et procede de preparation dudit cataplasme Withdrawn EP1663176A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10341933A DE10341933A1 (de) 2003-09-11 2003-09-11 Medizinische Hautpflaster mit einem Gehalt an ätherischen Ölen zur Behandlung von Erkältungskrankheiten, sowie Verfahren für deren Herstellung
PCT/EP2004/010046 WO2005025547A1 (fr) 2003-09-11 2004-09-09 Cataplasme medical a teneur en huiles essentielles pour traiter des maladies dues a un refroidissement, et procede de preparation dudit cataplasme

Publications (1)

Publication Number Publication Date
EP1663176A1 true EP1663176A1 (fr) 2006-06-07

Family

ID=34305678

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04764983A Withdrawn EP1663176A1 (fr) 2003-09-11 2004-09-09 Cataplasme medical a teneur en huiles essentielles pour traiter des maladies dues a un refroidissement, et procede de preparation dudit cataplasme

Country Status (4)

Country Link
US (1) US20070077281A1 (fr)
EP (1) EP1663176A1 (fr)
DE (1) DE10341933A1 (fr)
WO (1) WO2005025547A1 (fr)

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DE102015226645A1 (de) * 2015-12-23 2017-06-29 Karl Otto Braun Gmbh & Co. Kg Bandage
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CN109568021A (zh) * 2019-01-21 2019-04-05 合肥洁家卫生材料有限公司 一种具有抑菌功能的医用护理垫

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