EP1643954A1 - Titration/compliance pack - Google Patents

Titration/compliance pack

Info

Publication number
EP1643954A1
EP1643954A1 EP04756814A EP04756814A EP1643954A1 EP 1643954 A1 EP1643954 A1 EP 1643954A1 EP 04756814 A EP04756814 A EP 04756814A EP 04756814 A EP04756814 A EP 04756814A EP 1643954 A1 EP1643954 A1 EP 1643954A1
Authority
EP
European Patent Office
Prior art keywords
tablets
sets
different
rows
columns
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04756814A
Other languages
German (de)
French (fr)
Inventor
Zanden John Jacob Vander
Rodney Terwilliger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of EP1643954A1 publication Critical patent/EP1643954A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Definitions

  • the present invention is generally directed to a titration package for enabling compliance with a regimen of changing dosage of medication over a period of time and is more particularly directed to a dosage pack for dosing of oral Memantine for the indication of preventing further nerve cell loss in glaucoma patients.
  • Glaucoma is characterized by damaged to the optic nerve which is typically accompanied by a decrease in normal vision field.
  • An early sign of possible glaucomatous visual field loss is elevated interocular pressure.
  • glaucoma has typically been treated by medically and/or surgically lowering elevated interocular pressure.
  • Memantine and other compounds suitable for chronic administration should be administered to avoid adverse events associated with the drug, for example, patients prescribed Memantine therapy need to be titrated upwards from 5mg of Memantine per day to a maintenance dose of either lOmg or 20mg per day.
  • Memantine approved for other indications also requires similar titration schedules to avoid drug-related adverse events.
  • the present invention is directed to a titration package for enabling compliance with a regimen of changing dosage of medication over a period of time and further- provides for a method of treating a human patient to reduce damage to retinal ganglion cells associated with glaucoma utilizing the titration package in accordance with the present invention.
  • a titration package for enabling compliance with a regimen of changing dosage of medication over a period of time in accordance with the present invention generally includes a backing having an array of receivers with the array including a plurality of columns and a plurality of rows .
  • a plurality of sets of tablets are provided in the receivers.
  • Each tablet in a set has a common dose of medication and a different dose than a tablet of a different set.
  • Each set of tablets is disposed in receivers of one of an adjacent row and an adjacent column.
  • Indicia is provided and disposed adjacent the columns and rows for displaying common days and successive weeks.
  • the package provides for a titration schedule which prevents adverse events as a result of mis-dosing.
  • the package in accordance with the present invention provides for a safer and accordingly more beneficial method for enabling compliance with the regimen.
  • different sets of tablets are disposed in different rows with each row being indicated by a successive week and each column being indicated as a different day of the week.
  • the sets of tablets having increased doses are disposed in receivers in rows indicated as successive weeks. More specifically, the sets of tablets have 5mg, lOmg, 15mg and 20mg doses of Memantine.
  • different sets of tablets are disposed in different columns, with each column being indicated as a successive week and each row being indicated as a different day of the week.
  • the titration package for enabling compliance with a regimen of changing doses of medication over a period of time includes a backing having an array or receivers with the array including a plurality of columns and a plurality of rows.
  • a plurality of sets of tablets are provided with each set being disposed in receivers of a plurality of adjacent rows or a plurality of adjacent columns. This plurality may be two and each tablet in a set has a common dose of medication and a different dose than a tablet in a different set.
  • pairs of adjacent rows have differing sets of tablets. This enables the change of dosage over an eight-week period of time from 5mg to 20mg doses of Memantine.
  • the present invention provides for a method for enabling compliance with a regimen of changing dosage of medication with the method comprising the steps of providing a backing having an array of receivers, with the array including a plurality of columns and a plurality of rows.
  • the method further includes disposing a plurality of sets of tablets and the receivers with each tablet in the set having a common dose of medication and a different dose than a tablet of a different set.
  • Each set is disposed in receivers of one of an adjacent row and an adjacent column.
  • the method finally includes a step of providing indicia adjacent the columns and rows indicating common days and successive weeks.
  • a concomitant method in accordance with the present invention provides for a method of treating a human patient to reduce damage to retinal ganglion cells associated with glaucoma with the method comprising providing a titration package for enabling compliance with a regimen of changing dosage of medication over a period of time.
  • the package includes the elements hereinabove recited and further the medication comprises Memantine.
  • Figure 1 is a representation of a titration package in accordance with the present invention for enabling compliance with a regimen of changing dosage of medication over a four-week period of time;
  • Figure 2 is a representation of a titration package similar to that shown in Figure 1 enabling compliance with a regimen of changing dosage of medication over a period of eight weeks; and
  • Figure 3 is a representation similar to the titration package shown in Figure 2 showing an alternative arrangement of days and successive weeks, as will be hereinafter described.
  • the titration package and method in accordance to the present invention is particularly useful for the dosage of oral medication for infirmed and elderly patients and accordingly the manipulation of tablets enabled by the present invention and tracking of compliance with a titration schedule is a great advantage.
  • a titration package 10 for enabling compliance with a regimen of changing dosage of medication over a period of time, for example four weeks with the package 10 including a backing 12 which includes an array 18 of receivers holding a plurality of sets 24, 26, 28, 30 of tablets 34, 36, 38, 40.
  • the receivers 20 may be conventional, rupturable blisters as, for example, as set forth in U.S. RE29,705 which is to be incorporated herewith in its entirety for the purpose of describing the type of rupturable receivers suitable for use with the present invention.
  • the backing 12 may be any suitable plastic or paperboard backing and may be incorporated into protective coverings, not shown, such as, for example, shown in U.S. Patent No. 6,047,829. This patent is to also be incorporated herewith in its entirety by this specific reference thereto for showing a backing and dispensing package construction suitable for use in the present invention.
  • the array 18 of receivers 20 includes a plurality of columns indicated by the arrows 44 and a plurality of rows indicated by the arrows 46.
  • Indicia 50, 52 is provided and disposed adjacent the columns 44 and rows 46, preferably on the backing 12 displays common days and successive weeks. As shown in Figure 1, different sets are disposed in different rows 46 as indicated by week 1, week 2, week 3, and week 4. The number following the indicia "week" indicating successive weeks and the columns 44 indicated as Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, and Saturday indicating different days of the week.
  • the set 24 includes 5mg of Memantine
  • the set 26 includes tablets of lOmg of Memantine
  • the set 28 includes tablets of 15mg of Memantine
  • the set 30 includes tablets of 30mg of Memantine arranged in the rows 46 indicated as week 1, week 2, week 3, and week 4.
  • a patient utilizing the package and method of the present invention is titrated from a 5mg dose to a 20mg dose of the Memantine.
  • a patient beginning the regimen may start on any given day of the week, for example, Tuesday and progressively take the tablets by rupturing the receivers 20 along a row until all of the tablets 34 have been dispensed.
  • the patient begins week 2 of the regimen by taking the tablets 36 disposed in the row 46 indicated by the indicia, week 2.
  • the arrangement and dosages of the tablets therein enables compliance with the regimen of changing the dosage of the medication over the period of time, four weeks as indicated in Figure 1.
  • a backing 62 is provided with an array 66 of receivers 68 with the array being arranged in rows indicated by the indicia, "week 1 - 8" and columns indicated as “Sun-Sat” .
  • the titration packages 60, 100 enable compliance with a regimen of changing dosage of medication over a period of time as hereinabove described in connection with the package 10 shown in Figure 1.
  • the present invention may suitably comprise, consist of, or consist essentially of the recited elements.

Abstract

A titration package and method for enabling compliance with a regime of changing dosage of medication over a period of time includes a backing having an array of receivers with the array including a plurality of columns and a plurality of rows. A plurality of sets of tablets are provided with each tablet in set having a common dose of medication and a different dose than a tablet of a different set. Each set of tablets is disposed in receivers of one having an adjacent row and an adjacent column. Indicia is provided and disposed adjacent to the columns and rows for displaying common days and successive weeks.

Description

TITRATION/COMPLIANCE PACK
The present invention is generally directed to a titration package for enabling compliance with a regimen of changing dosage of medication over a period of time and is more particularly directed to a dosage pack for dosing of oral Memantine for the indication of preventing further nerve cell loss in glaucoma patients.
Glaucoma is characterized by damaged to the optic nerve which is typically accompanied by a decrease in normal vision field. An early sign of possible glaucomatous visual field loss is elevated interocular pressure.
In that regard, glaucoma has typically been treated by medically and/or surgically lowering elevated interocular pressure. Memantine and other compounds suitable for chronic administration should be administered to avoid adverse events associated with the drug, for example, patients prescribed Memantine therapy need to be titrated upwards from 5mg of Memantine per day to a maintenance dose of either lOmg or 20mg per day. Memantine approved for other indications also requires similar titration schedules to avoid drug-related adverse events.
The present invention is directed to a titration package for enabling compliance with a regimen of changing dosage of medication over a period of time and further- provides for a method of treating a human patient to reduce damage to retinal ganglion cells associated with glaucoma utilizing the titration package in accordance with the present invention.
SUMMARY OF THE INVENTION
A titration package for enabling compliance with a regimen of changing dosage of medication over a period of time in accordance with the present invention generally includes a backing having an array of receivers with the array including a plurality of columns and a plurality of rows .
A plurality of sets of tablets are provided in the receivers. Each tablet in a set has a common dose of medication and a different dose than a tablet of a different set. Each set of tablets is disposed in receivers of one of an adjacent row and an adjacent column.
Indicia is provided and disposed adjacent the columns and rows for displaying common days and successive weeks. Thus, the package provides for a titration schedule which prevents adverse events as a result of mis-dosing. As a result, the package in accordance with the present invention provides for a safer and accordingly more beneficial method for enabling compliance with the regimen.
More particularly, in one embodiment of the present invention different sets of tablets are disposed in different rows with each row being indicated by a successive week and each column being indicated as a different day of the week. In this embodiment, the sets of tablets having increased doses are disposed in receivers in rows indicated as successive weeks. More specifically, the sets of tablets have 5mg, lOmg, 15mg and 20mg doses of Memantine.
In an alternative embodiment, different sets of tablets are disposed in different columns, with each column being indicated as a successive week and each row being indicated as a different day of the week.
In yet another embodiment of the present invention, the titration package for enabling compliance with a regimen of changing doses of medication over a period of time includes a backing having an array or receivers with the array including a plurality of columns and a plurality of rows. In this embodiment, a plurality of sets of tablets are provided with each set being disposed in receivers of a plurality of adjacent rows or a plurality of adjacent columns. This plurality may be two and each tablet in a set has a common dose of medication and a different dose than a tablet in a different set.
Preferably, in this embodiment pairs of adjacent rows have differing sets of tablets. This enables the change of dosage over an eight-week period of time from 5mg to 20mg doses of Memantine.
Thus, the present invention provides for a method for enabling compliance with a regimen of changing dosage of medication with the method comprising the steps of providing a backing having an array of receivers, with the array including a plurality of columns and a plurality of rows. The method further includes disposing a plurality of sets of tablets and the receivers with each tablet in the set having a common dose of medication and a different dose than a tablet of a different set. Each set is disposed in receivers of one of an adjacent row and an adjacent column. The method finally includes a step of providing indicia adjacent the columns and rows indicating common days and successive weeks.
A concomitant method in accordance with the present invention provides for a method of treating a human patient to reduce damage to retinal ganglion cells associated with glaucoma with the method comprising providing a titration package for enabling compliance with a regimen of changing dosage of medication over a period of time. The package includes the elements hereinabove recited and further the medication comprises Memantine.
BRIEF DESCRIPTION OF THE DRAWINGS
The present invention may be more clearly understood with reference to the following detailed description in conjunction with the appended drawings of which:
Figure 1 is a representation of a titration package in accordance with the present invention for enabling compliance with a regimen of changing dosage of medication over a four-week period of time;
Figure 2 is a representation of a titration package similar to that shown in Figure 1 enabling compliance with a regimen of changing dosage of medication over a period of eight weeks; and Figure 3 is a representation similar to the titration package shown in Figure 2 showing an alternative arrangement of days and successive weeks, as will be hereinafter described.
DETAILED DESCRIPTION
The titration package and method in accordance to the present invention is particularly useful for the dosage of oral medication for infirmed and elderly patients and accordingly the manipulation of tablets enabled by the present invention and tracking of compliance with a titration schedule is a great advantage. In the case of treatment of glaucoma, and the use of a medicament, such as, for example Memantine, the progression of blindness also demands a need for the present invention. ith reference to Figure 1, there is represented a titration package 10 for enabling compliance with a regimen of changing dosage of medication over a period of time, for example four weeks with the package 10 including a backing 12 which includes an array 18 of receivers holding a plurality of sets 24, 26, 28, 30 of tablets 34, 36, 38, 40. The receivers 20 may be conventional, rupturable blisters as, for example, as set forth in U.S. RE29,705 which is to be incorporated herewith in its entirety for the purpose of describing the type of rupturable receivers suitable for use with the present invention.
The backing 12 may be any suitable plastic or paperboard backing and may be incorporated into protective coverings, not shown, such as, for example, shown in U.S. Patent No. 6,047,829. This patent is to also be incorporated herewith in its entirety by this specific reference thereto for showing a backing and dispensing package construction suitable for use in the present invention.
With continued reference to Figure 1, the array 18 of receivers 20 includes a plurality of columns indicated by the arrows 44 and a plurality of rows indicated by the arrows 46. Indicia 50, 52 is provided and disposed adjacent the columns 44 and rows 46, preferably on the backing 12 displays common days and successive weeks. As shown in Figure 1, different sets are disposed in different rows 46 as indicated by week 1, week 2, week 3, and week 4. The number following the indicia "week" indicating successive weeks and the columns 44 indicated as Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, and Saturday indicating different days of the week.
With regard to the treatment of glaucoma, the set 24 includes 5mg of Memantine, the set 26 includes tablets of lOmg of Memantine, the set 28 includes tablets of 15mg of Memantine, and the set 30 includes tablets of 30mg of Memantine arranged in the rows 46 indicated as week 1, week 2, week 3, and week 4. In accordance with the present invention, a patient utilizing the package and method of the present invention is titrated from a 5mg dose to a 20mg dose of the Memantine. In use, a patient beginning the regimen may start on any given day of the week, for example, Tuesday and progressively take the tablets by rupturing the receivers 20 along a row until all of the tablets 34 have been dispensed. At that time, the patient begins week 2 of the regimen by taking the tablets 36 disposed in the row 46 indicated by the indicia, week 2.
Thus, the arrangement and dosages of the tablets therein enables compliance with the regimen of changing the dosage of the medication over the period of time, four weeks as indicated in Figure 1.
With reference to Figure 2, there is shown an alternative embodiment, or package, 60 in accordance with the present invention for enabling compliance with a regimen of changing dosage of medication over a period of 8 weeks. In this embodiment, a backing 62 is provided with an array 66 of receivers 68 with the array being arranged in rows indicated by the indicia, "week 1 - 8" and columns indicated as "Sun-Sat" .
In this embodiment, different sets 72, 74, 76, 78 of tablets 82 are disposed in adjacent rows as shown in Figure 2 or an adjacent columns as shown in the embodiment 100 of Figure 3. Character references have been omitted from Figure 3 to reduce redundancy in description. It should be clear that the embodiment of 60 and 100 are identical except for the arrangement of columns and rows .
In a method of treating a human patient in accordance with the present invention to reduce damage to retinal ganglion cells associated with glaucoma, the titration packages 60, 100 enable compliance with a regimen of changing dosage of medication over a period of time as hereinabove described in connection with the package 10 shown in Figure 1.
The patient beginning on any of the week completes the removal and use of tablets in a corresponding week in adjacent rows or column before proceeding to the next pair of adjacent rows or columns in a manner as described hereinabove in connection with the embodiment 10 shown in Figure 1.
Although there has been hereinabove described a specific titration/compliance pack in accordance with the present invention for the purpose of illustrating the manner in which the invention may be used to advantage, it should be appreciated that the invention is not limited thereto.
That is, the present invention may suitably comprise, consist of, or consist essentially of the recited elements.
Further, the invention illustratively disclosed herein suitably may be practiced in the absence of any element which is not specifically disclose herein. Accordingly, any and all modifications, variations or equivalent arrangements which may occur to those skilled in the art, should be considered to be within the scope of the present invention as defined in the appended claims.

Claims

WHAT IS CLAIMED IS:
1. A titration package for enabling compliance with a regimen of changing dosage of medication over a period of time, the package comprising: a backing having an array of receivers, said array including a plurality of columns and a plurality of rows; a plurality of sets of tablets, each tablet in a set having a common dose of the medication and a different dose than a tablet of a different set, each set being disposed in receivers of one of an adjacent row and an adjacent column; and indicia disposed adjacent the columns and rows for displaying common days and successive weeks.
2. The package according to claim 1 wherein different sets of tablets are disposed in different rows, each row being indicated as a successive week, each column being indicated as a different day of the week.
3. The package according to claim 2 wherein sets of tablets having increased doses are disposed in recesses of rows indicated as successive weeks.
4. The package according to claim 3 wherein the sets of tablets have 5mg, lOmg, 15mg, and 20mg doses of Memantine.
5. The package according to claim 1 wherein different sets of tablets are disposed in different columns, each column being indicated as a successive week, each row being indicated as a different day of the week.
6. The package according to claim 5 wherein sets of tablets have increased doses are disposed in receivers of columns indicated as successive weeks.
7. The package according to claim 6 wherein the sets of tablets have 5mg, lOmg, 15mg and 20mg doses of Memantine.
8. A titration package for enabling compliance with a regimen of changing dosage of medication over a period of time, the package comprising: a backing having an array of receivers, said array including a plurality of columns and a plurality of rows; a plurality of sets of tablets, each tablet in a set having a common dose of the medication and a different dose than a tablet of a different set, each set being disposed in receivers of a plurality of adjacent rows or a plurality of adjacent columns; and indicia disposed adjacent the columns and rows for displaying common days and successive weeks.
9. The package according to claim 8 wherein pairs of adjacent rows have differing sets of tablets.
10. The package according to claim 9 wherein each rows is indicated as a successive week and each column is indicated as a different day of the week.
11. The package according to claim 10 wherein sets of tablets having increased doses are disposed in receivers of adjacent pairs of rows.
12. The package according to claim 11 wherein the sets of tablets have 5mg, lOmg, 15mg and 20mg doses of Memantine.
13. The package according to claim 8 wherein pairs of adjacent columns have differing sets of tablets.
14. The package according to claim 13 wherein each column is indicated as a successive week and each row is indicated as a different day of the week.
15. The package according to claim 14 wherein sets of tablets having increased doses are disposed in receivers of adjacent pairs of columns.
16. The package according to claim 15 wherein the sets of tablets have 5mg, lOmg, 15mg and 20 doses of Memantine.
17. A method for enabling compliance with a regimen of changing dosage of medication, the method comprises the steps of: providing a backing having an array of receivers, said array including a plurality of columns and a plurality of rows; disposing a plurality of sets of tables in the receivers, each tablet in a set having a common dose of medication and a different dose than a tablet of a different set, each set being disposed in receivers of one of an adjacent row and an adjacent column; and providing indicia adjacent the columns and rows indicating common days and successive weeks.
18. A method of treating a human patient to reduce damage to retinal ganglion cells associated with glaucoma, said method comprising providing a titration package for enabling compliance with a regimen of changing dosage of medication over a period of time, the package comprising: a backing having an array of receivers, said array including a plurality of columns and a plurality of rows; a plurality of sets of tablets, each tablet in a set having a common dose of the medication and a different dose than a tablet of a different set, each set being disposed in receivers of one of an adjacent row and an adjacent column; and indicia disposed adjacent the columns and rows for displaying common days and successive weeks.
19. The method according to claim 18 wherein the medication comprises Memantine.
20. The method according to claim 18 wherein different sets of tablets are disposed in different rows, each row being indicated as a successive week, each column being indicated as a different day of the week.
21. The method according to claim 18 wherein sets of tablets having increased doses are disposed in recesses of rows indicated as successive weeks.
22. The method according to claim 18 wherein the sets of tablets have 5mg, lOmg, 15mg, and 20mg doses of Memantine.
23. The method according to claim 18 wherein different sets of tablets are disposed in different columns, each column being indicated as a successive week, each row being indicated as a different day of the week.
24. The method according to claim 23 wherein sets of tablets have increased doses are disposed in receivers of columns indicated as successive weeks.
25. The method according to claim 18 wherein the sets of tablets have 5mg, lOmg, 15mg and 20mg doses of Memantine.
EP04756814A 2003-07-16 2004-07-09 Titration/compliance pack Withdrawn EP1643954A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/622,170 US7086532B2 (en) 2003-07-16 2003-07-16 Titration/compliance pack with increasing doses
PCT/US2004/021991 WO2005009326A1 (en) 2003-07-16 2004-07-09 Titration/compliance pack

Publications (1)

Publication Number Publication Date
EP1643954A1 true EP1643954A1 (en) 2006-04-12

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EP04756814A Withdrawn EP1643954A1 (en) 2003-07-16 2004-07-09 Titration/compliance pack

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US (3) US7086532B2 (en)
EP (1) EP1643954A1 (en)
JP (1) JP2007531541A (en)
KR (1) KR20060038998A (en)
CN (1) CN1822808A (en)
AU (1) AU2004258884A1 (en)
BR (1) BRPI0412583A (en)
CA (1) CA2532438A1 (en)
IL (1) IL173075A0 (en)
MX (1) MXPA06000466A (en)
NO (1) NO20060083L (en)
PL (1) PL379123A1 (en)
RU (1) RU2006105657A (en)
WO (1) WO2005009326A1 (en)
ZA (1) ZA200510420B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7086532B2 (en) * 2003-07-16 2006-08-08 Allergan, Inc. Titration/compliance pack with increasing doses
HUE034290T2 (en) 2003-04-29 2018-02-28 Orexigen Therapeutics Inc Compositions for affecting weight loss comprising an opioid antagonist and bupropion
WO2005109119A2 (en) 2004-04-24 2005-11-17 Inrange Systems, Inc. Integrated, non-sequential, remote medication management and compliance system
US7828147B2 (en) 2004-04-24 2010-11-09 Inrange Systems, Inc. Multi-layer medication carrier
US20070095850A1 (en) * 2005-10-27 2007-05-03 Meyer Daniel D Multiple medication dispensing system
CA2630624C (en) 2005-11-22 2013-08-06 Orexigen Therapeutics, Inc. Compositions and methods for increasing insulin sensitivity
US7909165B2 (en) * 2006-04-10 2011-03-22 Poppack, Llc System for delivering sequential components
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
AU2007319472B2 (en) * 2006-11-09 2013-01-17 Nalpropion Pharmaceuticals Llc Methods Of Administering Weight Loss Medications
EP2089005B1 (en) 2006-11-09 2010-03-17 Orexigen Therapeutics, Inc. Layered pharmaceutical formulations comprising an intermediate rapidly dissolving layer
AU2008298017B2 (en) * 2007-09-12 2012-03-01 Merz Pharma Gmbh & Co. Kgaa Titration package for neramexane and its use in the treatment of an inner ear disorder
EP2082717A1 (en) * 2008-01-28 2009-07-29 Merz Pharma GmbH & Co. KGaA Titration package
US20090230013A1 (en) * 2008-03-17 2009-09-17 The Procter & Gamble Company User-Customizable Dosing System
EP2303025A4 (en) 2008-05-30 2012-07-04 Orexigen Therapeutics Inc Methods for treating visceral fat conditions
US20100043255A1 (en) * 2008-08-21 2010-02-25 Trevino Steven M External sole liner and method of manufacturing and using the same
EP2177275A1 (en) 2008-10-16 2010-04-21 Merz Pharma GmbH & Co. KGaA Pump dispenser for the titration of pharmaceuticals
WO2010054202A2 (en) * 2008-11-06 2010-05-14 Leon Rosenberg Package of pills useful for titration and method of titrating a patient
US9248123B2 (en) 2010-01-11 2016-02-02 Orexigen Therapeutics, Inc. Methods of providing weight loss therapy in patients with major depression
US20120145585A1 (en) 2010-12-08 2012-06-14 Id-Con, Llc Packaging systems and methods
US8752704B2 (en) * 2010-12-17 2014-06-17 The Procter & Gamble Company Blister cards promoting intuitive dosing
US9445970B2 (en) 2010-12-17 2016-09-20 The Procter & Gamble Company Blister cards promoting intuitive dosing
US8905237B2 (en) 2010-12-17 2014-12-09 The Procter & Gamble Company Blister cards promoting intuitive dosing
US9351907B2 (en) 2011-07-19 2016-05-31 Id-Con, Llc Packaging systems and methods
JP5942405B2 (en) * 2011-12-07 2016-06-29 住友ベークライト株式会社 Tablet packaging
PL3730132T3 (en) 2012-06-06 2022-10-10 Nalpropion Pharmaceuticals Llc Composition for use in a method of treating overweight and obesity in patients with high cardiovascular risk
CN103112658A (en) * 2013-03-08 2013-05-22 苏州市职业大学 Bubble cap medicine packaging enabling user to set medicine-taking reminder autonomously
US10499706B2 (en) 2013-03-22 2019-12-10 Reebok International Limited Molded footwear upper and method of making same
US8969371B1 (en) 2013-12-06 2015-03-03 Orexigen Therapeutics, Inc. Compositions and methods for weight loss in at risk patient populations
MX2017005299A (en) 2014-10-23 2017-07-28 Arena Pharm Inc Method of treating conditions related to the pgi2 receptor.
US10527037B2 (en) 2016-04-18 2020-01-07 Baker Hughes, A Ge Company, Llc Mud motor stators and pumps and method of making
CA3054835A1 (en) 2017-03-01 2018-09-07 Arena Pharmaceuticals, Inc. Compositions comprising pgi2-receptor agonists and processes for the preparation thereof
US11406563B2 (en) 2018-07-27 2022-08-09 Société des Produits Nestlé S.A. Oral immunotherapy unit dose dispensing systems and methods
US11593679B2 (en) * 2019-11-29 2023-02-28 Kpn Innovations, Llc. Method of and system for generating a longevity element and an instruction set for a longevity element plan
WO2022194941A1 (en) * 2021-03-17 2022-09-22 Actelion Pharmaceuticals Ltd Pharmaceutical dosage system

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE30331C (en) * W. H. thompson in London, England Mills whose storage areas are protected from contamination by the grinding products by flushing with air or water
DE83668C (en) *
US383668A (en) * 1888-05-29 Electrical indicator for alternating electric currents
US2415859A (en) 1943-05-15 1947-02-18 Ancker Enock Tablet container and dispenser
US3099352A (en) 1961-09-28 1963-07-30 Aven Walter Calendar reminder and dispensing device
US3225913A (en) 1963-09-30 1965-12-28 Laurel M Lee Capsule and tablet pocket carrier
US3568828A (en) * 1967-03-01 1971-03-09 Squibb & Sons Inc Modified sequential oral contraceptive
US3494322A (en) * 1968-04-23 1970-02-10 Bristol Myers Co Pill dispensing means
US3738480A (en) 1971-11-17 1973-06-12 Central Res Labor Inc Medication container
US3809221A (en) 1972-10-10 1974-05-07 N Compere Rupturable blister pill package with safety backing
US3826222A (en) 1973-02-12 1974-07-30 J Romick Unit-dose medication handling system
US3921806A (en) 1974-06-10 1975-11-25 Joyce L Wawracz Pill dispenser
US4148273A (en) 1976-09-07 1979-04-10 Hollingsworth Delbert L Medicine management device
US4473884A (en) 1982-01-08 1984-09-25 Sybron Corporation Electronic medication dispensing system
US4706815A (en) * 1982-08-23 1987-11-17 American Home Products Corporation Dispensing container for triphasic
US4473156A (en) 1982-11-05 1984-09-25 St. Paul-Ramsey Hospital Medical Method and apparatus for accurately selecting storing and dispensing pills
US4617557A (en) 1984-11-08 1986-10-14 National Patent Development Corporation Medication compliance aid for unit dose packaging
CA1266179A (en) * 1986-01-23 1990-02-27 Clovis Poirier Baiting apparatus
US4958736A (en) * 1986-03-18 1990-09-25 Gynex, Inc. Package for oral contraceptive tablet
US4889236A (en) * 1988-02-26 1989-12-26 Warner-Lambert Company Credit card-style medication package
US4883180A (en) 1988-06-09 1989-11-28 Essie Mae Humphrey Color coded medicine caps and labels for daily dosage
US4889238A (en) * 1989-04-03 1989-12-26 The Procter & Gamble Company Medicament package for increasing compliance with complex therapeutic regimens
US5752235A (en) * 1990-01-17 1998-05-12 Informedix, Inc. Electronic medication monitoring and dispensing method
USD330331S (en) 1990-01-26 1992-10-20 Baker Cummins Pharamaceuticals, Inc. Unit dose drug control package
US5455279A (en) * 1991-04-19 1995-10-03 The Children's Medical Center Corporation Regimen method of mediating neuronal damage using nitroglycerine
US5922773A (en) * 1992-12-04 1999-07-13 The Children's Medical Center Corp. Glaucoma treatment
US5288107A (en) * 1993-01-27 1994-02-22 Engineered Data Products, Inc. Multiple information field label
USD383668S (en) 1994-11-01 1997-09-16 Medical Technology Systems, Inc. Portable electronic medication dispenser
JP2662206B2 (en) 1995-07-20 1997-10-08 日本イーライリリー株式会社 Tablet container
US6564945B1 (en) * 1997-07-14 2003-05-20 Robert E. Weinstein Medication assemblage for use in sinusitis treatment regimens
CA2218470A1 (en) 1997-12-12 1999-06-12 Derek T. Intini Discreet patient friendly compliance package
US6047829A (en) * 1998-09-18 2000-04-11 Westvaco Corporation Unit dose packaging system (UDPS) having a child resistant locking feature
US6169707B1 (en) * 1998-11-30 2001-01-02 Douglas A. Newland Medication storage and reminder device
US6375956B1 (en) * 1999-07-22 2002-04-23 Drugtech Corporation Strip pack
US6471645B1 (en) * 1999-12-30 2002-10-29 Medtronic, Inc. Communications system for an implantable device and a drug dispenser
US6411567B1 (en) * 2000-07-07 2002-06-25 Mark A. Niemiec Drug delivery management system
US6651816B2 (en) * 2001-05-04 2003-11-25 Robert E. Weinstein Antihistamine/decongestant regimens for treating rhinitis
US6491211B1 (en) * 2001-08-03 2002-12-10 Scott & Daniells, Inc. Child resistant carton and method for using the same
GB2380937A (en) 2001-10-18 2003-04-23 David Ian Slovick Method of dispensing a plurality of medical substances into capsules
US7086532B2 (en) * 2003-07-16 2006-08-08 Allergan, Inc. Titration/compliance pack with increasing doses
JP2004231588A (en) * 2003-01-31 2004-08-19 Takeda Chem Ind Ltd Method for treating neurodegenerative disease or the like
US20040176381A1 (en) * 2003-03-06 2004-09-09 Walsh Michael J. Methotrexate compliance packaging
RS20050851A (en) * 2003-05-27 2008-04-04 Forest Laboratories Inc., Combination of an nmda receptor antagonist and a selective serotonin reuptake inhibitor for the t reatment of depression and other mood disorders
EP1631273A1 (en) * 2003-06-16 2006-03-08 Allergan, Inc. Memantine oral dosage forms

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2005009326A1 *

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US7810643B2 (en) 2010-10-12
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