EP1638557A4 - Inhibiteurs de la glycogene synthase kinase-3 - Google Patents
Inhibiteurs de la glycogene synthase kinase-3Info
- Publication number
- EP1638557A4 EP1638557A4 EP04744910A EP04744910A EP1638557A4 EP 1638557 A4 EP1638557 A4 EP 1638557A4 EP 04744910 A EP04744910 A EP 04744910A EP 04744910 A EP04744910 A EP 04744910A EP 1638557 A4 EP1638557 A4 EP 1638557A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- inhibitors
- glycogen synthase
- synthase kinase
- kinase
- glycogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Wood Science & Technology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Child & Adolescent Psychology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48271903P | 2003-06-27 | 2003-06-27 | |
US52849503P | 2003-12-11 | 2003-12-11 | |
PCT/IL2004/000570 WO2005000192A2 (fr) | 2003-06-27 | 2004-06-27 | Inhibiteurs de la glycogene synthase kinase-3 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1638557A2 EP1638557A2 (fr) | 2006-03-29 |
EP1638557A4 true EP1638557A4 (fr) | 2007-11-07 |
Family
ID=33555590
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04744910A Ceased EP1638557A4 (fr) | 2003-06-27 | 2004-06-27 | Inhibiteurs de la glycogene synthase kinase-3 |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1638557A4 (fr) |
JP (1) | JP2007527859A (fr) |
KR (1) | KR20060018902A (fr) |
CN (1) | CN1838954B (fr) |
CA (1) | CA2530111A1 (fr) |
WO (1) | WO2005000192A2 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001049709A1 (fr) | 2000-01-03 | 2001-07-12 | Ramot University Authority For Applied Research & Industrial Development Ltd. | Inhibiteurs de glycogene synthase kinase-3 |
US7378432B2 (en) | 2001-09-14 | 2008-05-27 | Tel Aviv University Future Technology Development L.P. | Glycogen synthase kinase-3 inhibitors |
EP1569956B1 (fr) | 2002-12-12 | 2014-02-26 | Tel Aviv University Future Technology Development L.P. | Inhibiteurs de la glycogene synthase kinase-3 |
AU2005234687A1 (en) * | 2003-06-27 | 2005-12-08 | Tel Aviv Universtiy Future Technology Development L.P. | Glycogen Synthase Kinase-3 Inhibitors |
MX2011004258A (es) | 2008-10-22 | 2011-06-01 | Merck Sharp & Dohme | Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos. |
CA2741672A1 (fr) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Nouveaux agents antidiabetiques utiles avec des derives de benzimidazole cycliques |
CA2786314A1 (fr) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Nouveaux derives benzimidazole cycliques utiles comme agents antidiabetiques |
EP2668199B1 (fr) | 2011-01-27 | 2017-09-06 | Ramot at Tel Aviv University, Ltd. | Inhibiteurs de glycogène synthase kinase-3 |
WO2012101601A1 (fr) | 2011-01-27 | 2012-08-02 | Ramot At Tel-Aviv University Ltd. | Inhibiteurs de glycogène synthase kinase 3 |
KR101668514B1 (ko) | 2011-02-25 | 2016-10-21 | 머크 샤프 앤드 돔 코포레이션 | 항당뇨병제로서 유용한 신규 시클릭 아자벤즈이미다졸 유도체 |
JP2015525782A (ja) | 2012-08-02 | 2015-09-07 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 抗糖尿病性三環式化合物 |
RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
US9650375B2 (en) | 2013-03-14 | 2017-05-16 | Merck Sharp & Dohme Corp. | Indole derivatives useful as anti-diabetic agents |
EP3013850B1 (fr) | 2013-06-24 | 2018-07-25 | Ramot at Tel-Aviv University Ltd. | Inhibiteurs de glycogène synthase kinase-3 |
WO2015051496A1 (fr) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Composés tricycliques antidiabétiques |
WO2018106518A1 (fr) | 2016-12-06 | 2018-06-14 | Merck Sharp & Dohme Corp. | Composés hétérocycliques antidiabétiques |
US10968232B2 (en) | 2016-12-20 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB781806A (en) * | 1955-04-29 | 1957-08-28 | Roche Products Ltd | Organic phosphate, salts thereof, and process for the manufacture thereof |
WO1998005961A1 (fr) * | 1996-08-01 | 1998-02-12 | Isis Pharmaceuticals, Inc. | Composes contenant une pluralite de substituants azotes |
WO2002016318A1 (fr) * | 2000-08-21 | 2002-02-28 | Pacific Corporation | Nouveaux derives de thiourea et compositions pharmaceutiques renfermant ceux-ci |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB785457A (en) * | 1954-09-10 | 1957-10-30 | Ici Ltd | Phosphated metallisable azo dyestuffs |
JPS49125510A (fr) * | 1973-04-11 | 1974-12-02 | ||
JPS57212704A (en) * | 1981-06-24 | 1982-12-27 | Fujikura Ltd | Electric cable |
JPS5871937A (ja) * | 1981-10-23 | 1983-04-28 | Adeka Argus Chem Co Ltd | ハロゲン含有樹脂組成物 |
JPS63250063A (ja) * | 1987-04-03 | 1988-10-17 | Matsushita Electric Ind Co Ltd | 亜鉛アルカリ電池 |
US6441140B1 (en) * | 1998-09-04 | 2002-08-27 | Cell Signaling Technology, Inc. | Production of motif-specific and context-independent antibodies using peptide libraries as antigens |
WO2001049709A1 (fr) * | 2000-01-03 | 2001-07-12 | Ramot University Authority For Applied Research & Industrial Development Ltd. | Inhibiteurs de glycogene synthase kinase-3 |
CA2451994C (fr) * | 2001-07-16 | 2011-03-22 | Teijin Limited | Catalyseur destine a la production de polyester et procede de production de polyester faisant intervenir ce catalyseur |
-
2004
- 2004-06-27 WO PCT/IL2004/000570 patent/WO2005000192A2/fr active Application Filing
- 2004-06-27 JP JP2006516816A patent/JP2007527859A/ja active Pending
- 2004-06-27 KR KR1020057025051A patent/KR20060018902A/ko not_active Application Discontinuation
- 2004-06-27 EP EP04744910A patent/EP1638557A4/fr not_active Ceased
- 2004-06-27 CA CA002530111A patent/CA2530111A1/fr not_active Abandoned
- 2004-06-27 CN CN2004800240175A patent/CN1838954B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB781806A (en) * | 1955-04-29 | 1957-08-28 | Roche Products Ltd | Organic phosphate, salts thereof, and process for the manufacture thereof |
WO1998005961A1 (fr) * | 1996-08-01 | 1998-02-12 | Isis Pharmaceuticals, Inc. | Composes contenant une pluralite de substituants azotes |
WO2002016318A1 (fr) * | 2000-08-21 | 2002-02-28 | Pacific Corporation | Nouveaux derives de thiourea et compositions pharmaceutiques renfermant ceux-ci |
Also Published As
Publication number | Publication date |
---|---|
WO2005000192A2 (fr) | 2005-01-06 |
KR20060018902A (ko) | 2006-03-02 |
WO2005000192A3 (fr) | 2005-06-02 |
EP1638557A2 (fr) | 2006-03-29 |
JP2007527859A (ja) | 2007-10-04 |
CN1838954B (zh) | 2013-01-16 |
CN1838954A (zh) | 2006-09-27 |
CA2530111A1 (fr) | 2005-01-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL173381A0 (en) | 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors | |
GB2424882B (en) | Selective kinase inhibitors | |
IL175568A0 (en) | Azole-based kinase inhibitors | |
AP2048A (en) | Diazepinoindole derivatives as kinase inhibitors | |
AP2006003620A0 (en) | Imidazopyrazine tyroshine kinase inhibitors | |
IL172132A0 (en) | Thienopyridone derivatives as kinase inhibitors | |
IL173139A0 (en) | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors | |
PL373649A1 (en) | Kinase inhibitors | |
AU2003271566A8 (en) | Pyrrolopyrazines as kinase inhibitors | |
HK1091838A1 (en) | Gfat inhibitors | |
SI1569907T1 (sl) | Na nikotinamidu osnovani kinazni inhibitorji | |
AU2625201A (en) | Glycogen synthase kinase-3 inhibitors | |
EP1558609A4 (fr) | Inhibiteurs de kinase | |
GB2403757B (en) | Hydrate Inhibiting well fluids | |
EP1682547A4 (fr) | Inhibiteurs polymerase rsv | |
EP1638557A4 (fr) | Inhibiteurs de la glycogene synthase kinase-3 | |
EP1569907A4 (fr) | Inhibiteurs de kinase a base de nicotinamide | |
GB0324598D0 (en) | Cyclin groove inhibitors | |
GB0312619D0 (en) | Complement inhibitors | |
GB0300607D0 (en) | Inhibitors | |
GB0329869D0 (en) | Inhibitors | |
AU157608S (en) | Insert | |
GB0327386D0 (en) | Complement inhibitors | |
GB0303924D0 (en) | Modified nucleotides | |
GB0327146D0 (en) | Modified nucleotides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20051220 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20071008 |
|
R17P | Request for examination filed (corrected) |
Effective date: 20051220 |
|
R17P | Request for examination filed (corrected) |
Effective date: 20051220 |
|
17Q | First examination report despatched |
Effective date: 20100311 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R003 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
|
18R | Application refused |
Effective date: 20131205 |