EP1562425A1 - Mikrobizide mittel - Google Patents
Mikrobizide mittelInfo
- Publication number
- EP1562425A1 EP1562425A1 EP03758070A EP03758070A EP1562425A1 EP 1562425 A1 EP1562425 A1 EP 1562425A1 EP 03758070 A EP03758070 A EP 03758070A EP 03758070 A EP03758070 A EP 03758070A EP 1562425 A1 EP1562425 A1 EP 1562425A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- mixture according
- active
- bit
- tmad
- microorganisms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002855 microbicide agent Substances 0.000 title claims description 6
- 239000000126 substance Substances 0.000 title description 8
- 230000003641 microbiacidal effect Effects 0.000 title description 2
- 229940124561 microbicide Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 41
- UUGLSEIATNSHRI-UHFFFAOYSA-N 1,3,4,6-tetrakis(hydroxymethyl)-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-dione Chemical compound OCN1C(=O)N(CO)C2C1N(CO)C(=O)N2CO UUGLSEIATNSHRI-UHFFFAOYSA-N 0.000 claims abstract description 11
- DMSMPAJRVJJAGA-UHFFFAOYSA-N benzo[d]isothiazol-3-one Chemical compound C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 claims description 24
- 239000004480 active ingredient Substances 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 11
- 244000005700 microbiome Species 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 10
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 229910003002 lithium salt Inorganic materials 0.000 claims description 7
- 159000000002 lithium salts Chemical class 0.000 claims description 7
- 229910052700 potassium Inorganic materials 0.000 claims description 7
- 239000011591 potassium Substances 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000004606 Fillers/Extenders Substances 0.000 claims description 5
- 230000006378 damage Effects 0.000 claims description 5
- 239000012770 industrial material Substances 0.000 claims description 4
- 230000003115 biocidal effect Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 206010061217 Infestation Diseases 0.000 claims 2
- 239000011877 solvent mixture Substances 0.000 claims 2
- 230000002195 synergetic effect Effects 0.000 abstract description 10
- 230000000845 anti-microbial effect Effects 0.000 abstract description 4
- KANAPVJGZDNSCZ-UHFFFAOYSA-N 1,2-benzothiazole 1-oxide Chemical compound C1=CC=C2S(=O)N=CC2=C1 KANAPVJGZDNSCZ-UHFFFAOYSA-N 0.000 abstract 1
- -1 Chloromethylisothiazolinone p-chloro-m-cresol dimethylol urea Chemical compound 0.000 description 11
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 9
- 239000000047 product Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 239000000969 carrier Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 239000002480 mineral oil Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
- 241000589540 Pseudomonas fluorescens Species 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 239000003973 paint Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 239000011435 rock Substances 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 239000004567 concrete Substances 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 239000004088 foaming agent Substances 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 239000000976 ink Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 235000010446 mineral oil Nutrition 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000011118 polyvinyl acetate Substances 0.000 description 2
- 229920002689 polyvinyl acetate Polymers 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- YFLDZPUXCOSOGU-UHFFFAOYSA-N 1-iodoprop-2-ynyl n-butylcarbamate Chemical compound CCCCNC(=O)OC(I)C#C YFLDZPUXCOSOGU-UHFFFAOYSA-N 0.000 description 1
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000588986 Alcaligenes Species 0.000 description 1
- 241000588813 Alcaligenes faecalis Species 0.000 description 1
- 241000223600 Alternaria Species 0.000 description 1
- 241000223602 Alternaria alternata Species 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 241000228245 Aspergillus niger Species 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- LVDKZNITIUWNER-UHFFFAOYSA-N Bronopol Chemical compound OCC(Br)(CO)[N+]([O-])=O LVDKZNITIUWNER-UHFFFAOYSA-N 0.000 description 1
- 229910021532 Calcite Inorganic materials 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 241000221955 Chaetomium Species 0.000 description 1
- 241001515917 Chaetomium globosum Species 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- 241000427940 Fusarium solani Species 0.000 description 1
- 241000159512 Geotrichum Species 0.000 description 1
- 244000168141 Geotrichum candidum Species 0.000 description 1
- 235000017388 Geotrichum candidum Nutrition 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 241000222418 Lentinus Species 0.000 description 1
- 241000222451 Lentinus tigrinus Species 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- 241000228143 Penicillium Species 0.000 description 1
- 241001123663 Penicillium expansum Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241000223252 Rhodotorula Species 0.000 description 1
- 241000223254 Rhodotorula mucilaginosa Species 0.000 description 1
- 239000004113 Sepiolite Substances 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 239000002174 Styrene-butadiene Substances 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 229940005347 alcaligenes faecalis Drugs 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000010426 asphalt Substances 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 229960003168 bronopol Drugs 0.000 description 1
- MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000005068 cooling lubricant Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
- 239000002283 diesel fuel Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000010459 dolomite Substances 0.000 description 1
- 229910000514 dolomite Inorganic materials 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 239000001034 iron oxide pigment Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000004579 marble Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 229940042880 natural phospholipid Drugs 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- PETXWIMJICIQTQ-UHFFFAOYSA-N phenylmethoxymethanol Chemical compound OCOCC1=CC=CC=C1 PETXWIMJICIQTQ-UHFFFAOYSA-N 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920005553 polystyrene-acrylate Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- 239000008262 pumice Substances 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 229910052624 sepiolite Inorganic materials 0.000 description 1
- 235000019355 sepiolite Nutrition 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000011115 styrene butadiene Substances 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
Definitions
- the present application relates to new mixtures containing 1,2-benzisothiazolinone (BIT) and tetramethylolacetylene diurea (TMAD), processes for their preparation and their use for protecting technical materials and products from attack and destruction by microorganisms, and microbicidal agents based on these new mixtures ,
- BIT 1,2-benzisothiazolinone
- TMAD tetramethylolacetylene diurea
- 1, 2-Benzisothiazolinone (BIT) or its sodium, potassium or lithium salts have long been used in practice for the preparation of microbicidal formulations.
- 1,2-Benzisothiazolinone (BIT) is characterized by good chemical and thermal stability and basically has a broad antimicrobial effect (bacteria, fungi, yeasts). However, the effective level against certain types of bacteria is not always satisfactory and the observed level
- the speed of action is in some cases not sufficient to avoid microbiologically induced material damage.
- Tetramethylolacetylenediourea is a well-known biocide based on a formaldehyde releaser and has already been used for a wide variety of industrial preservation applications (adhesives, paints, concrete additives, etc.). Tetramethylolacetylene diurea (TMAD) has the favorable properties typical of a formaldehyde releaser, e.g. good bactericidal activity, rapid onset of action and gas phase activity. However, due to the limited spectrum of activity of formaldehyde releasers (focus on bacteria) in practice, in order to achieve satisfactory results, dosing quantities are necessary in some cases that appear to be in need of improvement in terms of safe and economical use.
- the present invention therefore relates to mixtures which are characterized in that they contain 1,2-benzisothiazolinone (BIT) and / or its sodium, potassium or lithium salts and tetramethylolacetylene diurea (TMAD) as active components.
- BIT 1,2-benzisothiazolinone
- TMAD tetramethylolacetylene diurea
- the mixtures according to the invention have a strong action against microorganisms and can be used to protect industrial materials against attack and destruction by microorganisms.
- the mixtures according to the invention are surprisingly characterized in that they have an unexpectedly high, synergistic increase in activity in specific mixing ratios. It follows from this that the concentrations required to protect technical products in the case of the mixtures according to the invention can be reduced compared to the concentrations required in the case of the individual active compounds. This is extremely advantageous from an economic, ecological and application point of view and makes a contribution to increasing the quality of the preservation.
- Chemical building products such as concrete additives, for example based on molasses, lignin sulfonates or polyacrylates, bitumen emulsions or joint sealants
- the mixtures according to the invention can additionally contain one or more further biocidal active ingredients.
- the compounds are the mixing partners
- Quaternary ammonium salts e.g. N-alkyl-N, N-dimethyl-benzyl-ammonium chloride
- BIT 1,2-benzisothiazolinone
- TMAD tetramethylolacetylene diurea
- the mixtures according to the invention can be used in material protection to protect industrial materials, in particular to protect aqueous functional liquids; they are effective against bacteria, mold, yeast and mucus organisms.
- the following microorganisms may be mentioned as examples, but without limitation: Alternaria like Alternaria tenuis, Aspergillus like Aspergillus niger, Chaetomium like Chaetomium globosum, Fusarium like Fusarium solani, Lentinus like Lentinus tigrinus, Penicillium like Penicillium glaucum;
- Alcaligenes such as Alcaligenes faecalis, Bacillus such as Bacillus subtilis, Escherichia such as Escherichia coli, Pseudomonas such as Pseudomonas aeruginosa or Pseudomonas fluorescens, Staphylococcus such as Staphylococcus aureus;
- Candida such as Candida albicans, Geotrichum such as Geotrichum candidum, Rhodotorula such as Rhodotorula rubra.
- the mixtures according to the invention can be prepared by the
- the mixtures according to the invention can either be applied separately in the form of a metering in of the individual active compounds, depending on the preservation problem present, an individual setting of the concentration ratio can be carried out, or the finished items can be metered in Mixing done. It is also possible to previously mix the mixture according to the invention in a customary formulation such as Solutions, emulsions, suspensions,
- Powders, foams, pastes, granules, aerosols and very fine encapsulations to be converted into polymeric substances.
- formulations are prepared in a manner known per se, for example by mixing the mixture according to the invention or individual active ingredients contained therein with extenders, that is to say liquid solvents, pressurized liquefied gases and / or solid carriers, if appropriate using surface-active agents, that is to say emulsifiers and / or dispersing agents and / or foaming agents. If water is used as an extender, organic solvents can, for example, also be used as auxiliary solvents.
- extenders that is to say liquid solvents, pressurized liquefied gases and / or solid carriers, if appropriate using surface-active agents, that is to say emulsifiers and / or dispersing agents and / or foaming agents.
- surface-active agents that is to say emulsifiers and / or dispersing agents and / or foaming agents.
- organic solvents can, for example, also be used as auxiliary solvents.
- liquid solvents such as butanol or glycols and their ethers and esters, ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethylformamide or dimethyl sulfoxide, and water;
- Liquefied gaseous extenders or carriers mean liquids which are gaseous at normal temperature and under normal pressure, for example
- Aerosol propellants such as halogenated hydrocarbons and butane, propane, nitrogen and carbon dioxide
- solid carriers are possible: e.g. natural rock powders such as kaolins, alumina, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth and synthetic rock powders such as highly disperse silica, aluminum oxide and silicates; solid carriers for granules are possible: e.g.
- emulsifying and / or foaming agents are possible: e.g. non-ionic and anionic emulsifiers, such as
- Polyoxyethylene fatty acid esters polyoxyethylene fatty alcohol ethers, e.g. Alkylaryl polyglycol ethers, alkyl sulfonates, alkyl sulfates, aryl sulfonates and protein hydrolysates; as dispersants are e.g. Lignin sulfite leaching in question.
- Adhesives and thickeners such as carboxymethyl cellulose, natural and synthetic, powdery, granular or latex-shaped polymers, such as gum arabic, polyvinyl alcohol, polyvinyl acetate, and natural phospholipids, such as cephalins and lecithins and synthetic phospholipids, can be used in the formulations.
- Other additives can be mineral and vegetable oils.
- the present invention furthermore relates to microbicidal agents based on the active compound mixtures according to the invention, comprising at least one solvent or diluent and, if appropriate, processing aids and, if appropriate, further antimicrobial substances.
- the microbicidal agents or formulated concentrates to be used to protect industrial materials contain the active ingredients 1,2-benzisothiazolinone (BIT) and / or its sodium, potassium or lithium salts and tetramethylolacetylenediourea (TMAD), calculated as the sum of both active ingredients a concentration of 5 to 80% by weight, preferably 10 to 60% by weight.
- BIT 1,2-benzisothiazolinone
- TMAD tetramethylolacetylenediourea
- the application concentrations of the active compound combinations to be used according to the invention depend on the type and the occurrence of the microorganisms to be controlled, the initial microbial load and the composition of the material to be protected. The optimum amount of use for a specific application can be determined in the laboratory before the practical use. In general, the application concentrations are in the range from 0.01 to 5% by weight, preferably from 0.05 to 1.0% by weight, of the mixture according to the invention, based on the material to be protected.
- the mixtures according to the invention are distinguished by synergistic effects, i.e. the effectiveness of the mixture is greater than the effectiveness of the individual components.
- the found synergism of the mixtures according to the invention can be determined using the following mathematical approach (cf. F.C. Kuli, P.C. Elisman, HD. Sylwestrowicz and P.K. Mayer, Appl. Microbiol. 9, 538 (1961):
- Q a amount of component A in the active compound mixture which achieves the desired effect, ie no microbial growth
- QA amount of component A used alone, the growth of
- Qb amount of component B in the active ingredient mixture, which suppresses the growth of the microorganisms.
- QB amount of component B, used alone, suppresses the growth of the microorganisms.
- a synergistic index of SI ⁇ 1 indicates a synergistic effect for the active ingredient mixture.
- Test germ Pseudomonas aeruginosa
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10251915A DE10251915A1 (de) | 2002-11-08 | 2002-11-08 | Mikrobizide Mittel |
| DE10251915 | 2002-11-08 | ||
| PCT/EP2003/011884 WO2004040980A1 (de) | 2002-11-08 | 2003-10-25 | Mikrobizide mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1562425A1 true EP1562425A1 (de) | 2005-08-17 |
Family
ID=32115358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP03758070A Withdrawn EP1562425A1 (de) | 2002-11-08 | 2003-10-25 | Mikrobizide mittel |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20060111410A1 (enExample) |
| EP (1) | EP1562425A1 (enExample) |
| JP (1) | JP2006505596A (enExample) |
| KR (1) | KR20060006761A (enExample) |
| CN (1) | CN1725953A (enExample) |
| AU (1) | AU2003274084A1 (enExample) |
| BR (1) | BR0316085A (enExample) |
| CA (1) | CA2505002A1 (enExample) |
| DE (1) | DE10251915A1 (enExample) |
| HR (1) | HRP20050510A2 (enExample) |
| MX (1) | MXPA05004986A (enExample) |
| NO (1) | NO20052701D0 (enExample) |
| PL (1) | PL376601A1 (enExample) |
| RU (1) | RU2005116970A (enExample) |
| WO (1) | WO2004040980A1 (enExample) |
| ZA (1) | ZA200503640B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005013956A1 (de) * | 2005-03-26 | 2006-09-28 | Lanxess Deutschland Gmbh | Wasserbasierte BIT/TMAD Formulierungen |
| US9723842B2 (en) * | 2006-05-26 | 2017-08-08 | Arch Chemicals, Inc. | Isothiazolinone biocides enhanced by zinc ions |
| JP2009149610A (ja) * | 2007-12-20 | 2009-07-09 | Rohm & Haas Co | 相乗的殺微生物性組成物 |
| US9345241B2 (en) | 2008-04-11 | 2016-05-24 | Omya International Ag | Composition having biocide activity for aqueous preparations |
| RS52842B (sr) * | 2008-04-11 | 2013-12-31 | Omya Development Ag | Kompozicije sa biocidnom aktivnošću za vodene preparate |
| EP2158813A1 (en) | 2008-08-28 | 2010-03-03 | Omya Development AG | Stabilisation of aqueous mineral preparations by reuterin |
| DE102009013501A1 (de) | 2009-03-17 | 2010-09-23 | Daimler Ag | Hydrophobes Antifouling-Beschichtungsgemisch |
| JP5210360B2 (ja) * | 2009-07-30 | 2013-06-12 | ローム アンド ハース カンパニー | 相乗的殺微生物組成物 |
| CN101669486B (zh) * | 2009-10-16 | 2012-06-06 | 深圳诺普信农化股份有限公司 | 一种含苯醚菌酯的杀菌组合物 |
| EP2509416B1 (en) | 2009-12-07 | 2015-08-19 | Omya International AG | Process for reducing and/or maintaining the total viable count of bacteria in aqueous ground natural calcium carbonate and/or precipitated calcium carbonate and/or dolomite and/or surface-reacted calcium carbonate-comprising mineral preparations |
| EP2374353B1 (en) | 2010-04-09 | 2012-10-31 | Omya Development AG | Process to preserve aqueous preparations of mineral materials, preserved aqueous preparations of mineral materials and use of preservative compounds in aqueous preparations of mineral materials |
| EP2596702B1 (en) | 2011-11-25 | 2015-05-27 | Omya International AG | Process for stabilizing bacterial content of aqueous ground natural calcium carbonate and/or precipitated calcium carbonate and/or dolomite and/or surface-reacted calcium carbonate-comprising mineral preparations |
| CN103290678B (zh) * | 2013-04-13 | 2015-07-22 | 徐茂航 | 一种用于纺织品抗菌整理剂 |
| EP2929781A1 (en) | 2014-04-10 | 2015-10-14 | Omya International AG | MIC reduction with lithium ions |
| EP2982247A1 (en) | 2014-08-07 | 2016-02-10 | Omya International AG | Antiseptic product, process for preparing same and its use |
| EP3183969A1 (en) | 2015-12-22 | 2017-06-28 | Omya International AG | Metal oxides and/or hydrates thereof for stabilising an aqueous preparation against microbial growth |
| EP3403505A1 (en) | 2017-05-16 | 2018-11-21 | Omya International AG | Biocide free preservation |
| EP3726993A1 (de) * | 2017-12-22 | 2020-10-28 | THOR GmbH | Lagerstabile tmad / bit formulierung |
| EP3753409A1 (en) | 2019-06-18 | 2020-12-23 | Omya International AG | Use of urea as an antimicrobial additive in an aqueous suspension |
| EP4540326A1 (en) | 2022-06-15 | 2025-04-23 | Omya International AG | Storage stabilization agent for stabilizing aqueous compositions, process for stabilizing and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432433B1 (en) * | 2000-06-05 | 2002-08-13 | Isp Investments Inc. | Liquid biocidal composition of a formaldehyde adduct and an isothiazolone and method of use |
| DE10112755A1 (de) * | 2001-03-16 | 2002-10-02 | Bode Chemie Gmbh & Co Kg | Synergistische biozide Wirkstoffkombinationen, Zusammensetzungen, solche Wirkstoffkombinationen enthaltend, und Verwendung solcher Zusammensetzungen als Konservierungsmittel |
-
2002
- 2002-11-08 DE DE10251915A patent/DE10251915A1/de not_active Withdrawn
-
2003
- 2003-10-25 CA CA002505002A patent/CA2505002A1/en not_active Abandoned
- 2003-10-25 KR KR1020057008033A patent/KR20060006761A/ko not_active Withdrawn
- 2003-10-25 EP EP03758070A patent/EP1562425A1/de not_active Withdrawn
- 2003-10-25 CN CNA2003801058940A patent/CN1725953A/zh active Pending
- 2003-10-25 RU RU2005116970/04A patent/RU2005116970A/ru not_active Application Discontinuation
- 2003-10-25 JP JP2004548788A patent/JP2006505596A/ja not_active Withdrawn
- 2003-10-25 AU AU2003274084A patent/AU2003274084A1/en not_active Abandoned
- 2003-10-25 HR HR20050510A patent/HRP20050510A2/xx not_active Application Discontinuation
- 2003-10-25 WO PCT/EP2003/011884 patent/WO2004040980A1/de not_active Ceased
- 2003-10-25 MX MXPA05004986A patent/MXPA05004986A/es unknown
- 2003-10-25 BR BR0316085-8A patent/BR0316085A/pt not_active IP Right Cessation
- 2003-10-25 PL PL376601A patent/PL376601A1/pl unknown
- 2003-10-25 US US10/533,977 patent/US20060111410A1/en not_active Abandoned
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- 2005-05-06 ZA ZA200503640A patent/ZA200503640B/xx unknown
- 2005-06-06 NO NO20052701A patent/NO20052701D0/no not_active Application Discontinuation
Non-Patent Citations (1)
| Title |
|---|
| See references of WO2004040980A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006505596A (ja) | 2006-02-16 |
| DE10251915A1 (de) | 2004-05-19 |
| RU2005116970A (ru) | 2005-11-20 |
| BR0316085A (pt) | 2005-09-27 |
| AU2003274084A1 (en) | 2004-06-07 |
| CN1725953A (zh) | 2006-01-25 |
| NO20052701L (no) | 2005-06-06 |
| MXPA05004986A (es) | 2005-11-23 |
| PL376601A1 (pl) | 2006-01-09 |
| ZA200503640B (en) | 2007-02-28 |
| WO2004040980A1 (de) | 2004-05-21 |
| NO20052701D0 (no) | 2005-06-06 |
| CA2505002A1 (en) | 2004-05-21 |
| HRP20050510A2 (en) | 2006-06-30 |
| US20060111410A1 (en) | 2006-05-25 |
| KR20060006761A (ko) | 2006-01-19 |
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