EP1553946A4 - Amelioration du sommeil a l'aide d'antagonistes des canaux calciques de type t - Google Patents

Amelioration du sommeil a l'aide d'antagonistes des canaux calciques de type t

Info

Publication number
EP1553946A4
EP1553946A4 EP03809092A EP03809092A EP1553946A4 EP 1553946 A4 EP1553946 A4 EP 1553946A4 EP 03809092 A EP03809092 A EP 03809092A EP 03809092 A EP03809092 A EP 03809092A EP 1553946 A4 EP1553946 A4 EP 1553946A4
Authority
EP
European Patent Office
Prior art keywords
sleep
enhancement
calcium channel
type calcium
channel antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03809092A
Other languages
German (de)
English (en)
Other versions
EP1553946A2 (fr
Inventor
John Joseph Renger
Kenneth S Koblan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1553946A2 publication Critical patent/EP1553946A2/fr
Publication of EP1553946A4 publication Critical patent/EP1553946A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP03809092A 2002-10-17 2003-10-15 Amelioration du sommeil a l'aide d'antagonistes des canaux calciques de type t Withdrawn EP1553946A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41920302P 2002-10-17 2002-10-17
US419203P 2002-10-17
PCT/US2003/032892 WO2004035000A2 (fr) 2002-10-17 2003-10-15 Amelioration du sommeil a l'aide d'antagonistes des canaux calciques de type t

Publications (2)

Publication Number Publication Date
EP1553946A2 EP1553946A2 (fr) 2005-07-20
EP1553946A4 true EP1553946A4 (fr) 2008-07-16

Family

ID=32108042

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03809092A Withdrawn EP1553946A4 (fr) 2002-10-17 2003-10-15 Amelioration du sommeil a l'aide d'antagonistes des canaux calciques de type t

Country Status (4)

Country Link
US (1) US20060003985A1 (fr)
EP (1) EP1553946A4 (fr)
AU (1) AU2003277418A1 (fr)
WO (1) WO2004035000A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1858520B1 (fr) * 2005-03-09 2011-10-05 Merck Sharp & Dohme Corp. Antagonistes de canaux calciques de type t a base de quinazolinone
FR2888748B1 (fr) * 2005-07-19 2007-10-12 Biocodex Composes neuroprotecteurs et compositions pharmaceutiques les comprenant
CN101557855B (zh) * 2006-09-28 2013-08-28 威斯康星校友研究基地 用于促进恢复性睡眠的方法及设备
WO2008112715A2 (fr) * 2007-03-12 2008-09-18 Vm Discovery Inc. Nouveaux agents modulateurs des canaux d'ions calcium
CA2685753A1 (fr) * 2007-05-09 2008-11-20 Neuromed Pharmaceuticals Ltd. Derives bicycliques de pyrimidine en tant que bloqueurs des canaux calciques
US20090012010A1 (en) * 2007-05-18 2009-01-08 Neuromed Phramaceuticals Ltd. Amino acid derivatives as calcium channel blockers
WO2009132452A1 (fr) * 2008-04-28 2009-11-05 Neuromed Pharmaceuticals Ltd. Dérivés diaryl-cyclyalkyle utilisés comme inhibiteurs des canaux calciques
US20090270413A1 (en) * 2008-04-28 2009-10-29 Galemmo Jr Robert Di-t-butylphenyl piperazines as calcium channel blockers
WO2009132453A1 (fr) * 2008-04-28 2009-11-05 Neuromed Pharmaceuticals Ltd. Dérivés de cyclylamine utilisés comme agents bloquant le canal calcique
US20090298834A1 (en) * 2008-06-02 2009-12-03 Hassan Pajouhesh 4-(aminomethyl)cyclohexanamine derivatives as calcium channel blockers
US8377968B2 (en) 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
TW201242965A (en) 2011-02-01 2012-11-01 Kyowa Hakko Kirin Co Ltd Ring-fused heterocyclic derivative
WO2012116440A1 (fr) 2011-03-03 2012-09-07 Zalicus Pharmaceuticals Ltd. Inhibiteurs de type benzimidazole du canal sodique
CN104619707A (zh) 2012-07-31 2015-05-13 协和发酵麒麟株式会社 稠环杂环化合物
US10208023B2 (en) 2013-03-01 2019-02-19 Mark G. DeGiacomo Heterocyclic inhibitors of the sodium channel
MX2018004947A (es) 2015-10-22 2018-11-09 Cavion Inc Metodos para el tratamiento de sindrome de angelman y de los trastornos relacionados.
EP3585376A4 (fr) 2017-02-15 2020-11-25 Cavion, Inc. Inhibiteurs de canaux calciques
KR102654466B1 (ko) 2017-04-26 2024-04-08 카비온, 인코포레이티드 기억 및 인지 개선 방법 및 기억 및 인지 장애 치료 방법
BR112021006398A2 (pt) 2018-10-03 2021-07-06 Cavion Inc tratamento de tremor essencial usando (r)-2-(4-isopropilfenil)-n-(1-(5-(2,2,2-trifluoretoxi)piridin-2-il)etil) acetamida
WO2021007487A1 (fr) 2019-07-11 2021-01-14 Praxis Precision Medicines, Inc. Formulations de modulateurs de canal calcique de type t et leurs procédés d'utilisation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000002455A1 (fr) * 1998-07-09 2000-01-20 Cv Technologies Inc. Hypericine et extrait d'hypericum: agents bloquant les canaux de calcium de type c et leur utilisation comme agents therapeutiques diriges contre le canal de calcium de type t
WO2000037616A1 (fr) * 1998-12-23 2000-06-29 Cytoscan Sciences L.L.C. Compositions, techniques de depistage et methodes de traitement de troubles des systemes nerveux central et peripherique
WO2001062740A1 (fr) * 2000-02-25 2001-08-30 South Alabama Medical Science Foundation Analogues de mibefradil et leur utilisation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE462286B (sv) * 1988-10-13 1990-05-28 Avesta Ab Saett vid framstaellning av rostfria band och plaatar med god ytjaemnhet och glans
US5484886A (en) * 1991-04-25 1996-01-16 Merck & Co., Inc. Human neurokinin-1 receptor
EP1780278A3 (fr) * 1999-07-02 2007-06-27 Neuromed Technologies, Inc. Nuveaux canaux calciques mammiferes et sondes, lignees cellulaires et procedes correspondants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000002455A1 (fr) * 1998-07-09 2000-01-20 Cv Technologies Inc. Hypericine et extrait d'hypericum: agents bloquant les canaux de calcium de type c et leur utilisation comme agents therapeutiques diriges contre le canal de calcium de type t
WO2000037616A1 (fr) * 1998-12-23 2000-06-29 Cytoscan Sciences L.L.C. Compositions, techniques de depistage et methodes de traitement de troubles des systemes nerveux central et peripherique
WO2001062740A1 (fr) * 2000-02-25 2001-08-30 South Alabama Medical Science Foundation Analogues de mibefradil et leur utilisation

Also Published As

Publication number Publication date
EP1553946A2 (fr) 2005-07-20
WO2004035000A3 (fr) 2005-04-28
AU2003277418A1 (en) 2004-05-04
WO2004035000A2 (fr) 2004-04-29
AU2003277418A8 (en) 2004-05-04
US20060003985A1 (en) 2006-01-05

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