EP1552783A1 - Vorrichtung und Methode zur Messung des Blutflusses mittels Biophotonenemission - Google Patents

Vorrichtung und Methode zur Messung des Blutflusses mittels Biophotonenemission Download PDF

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Publication number
EP1552783A1
EP1552783A1 EP05250091A EP05250091A EP1552783A1 EP 1552783 A1 EP1552783 A1 EP 1552783A1 EP 05250091 A EP05250091 A EP 05250091A EP 05250091 A EP05250091 A EP 05250091A EP 1552783 A1 EP1552783 A1 EP 1552783A1
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EP
European Patent Office
Prior art keywords
bio
photon emission
detector
living body
measuring
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Granted
Application number
EP05250091A
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English (en)
French (fr)
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EP1552783B1 (de
Inventor
Sang-hoon 112-302 Top Maeul Sunkyoung Apt. Shin
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Samsung Electronics Co Ltd
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Samsung Electronics Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47F—SPECIAL FURNITURE, FITTINGS, OR ACCESSORIES FOR SHOPS, STOREHOUSES, BARS, RESTAURANTS OR THE LIKE; PAYING COUNTERS
    • A47F8/00—Dummies, busts or the like, e.g. for displaying garments
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47F—SPECIAL FURNITURE, FITTINGS, OR ACCESSORIES FOR SHOPS, STOREHOUSES, BARS, RESTAURANTS OR THE LIKE; PAYING COUNTERS
    • A47F7/00—Show stands, hangers, or shelves, adapted for particular articles or materials
    • A47F7/10—Show stands, hangers, or shelves, adapted for particular articles or materials for hosiery
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B5/00—Joining sheets or plates, e.g. panels, to one another or to strips or bars parallel to them
    • F16B5/02—Joining sheets or plates, e.g. panels, to one another or to strips or bars parallel to them by means of fastening members using screw-thread

Definitions

  • the present invention relates to a device for and method of measuring blood flow. More particularly, the present invention relates to a device for and method of measuring blood flow using bio-photon emission.
  • CVDs Cardiovascular diseases
  • a cerebral apoplexy i.e., a stroke
  • Thrombus may be produced in portions of a body, such as the heart and its adjacent organs, where the arteries are hardening.
  • mental stress reduces the amount of blood that flows into the heart, thus resulting in a high probability of death from heart disease.
  • death from heart disease most likely occurs in patients whose coronary arteries, which send blood to the heart, narrow by 50% in at least one portion of the coronary arteries or who have already had one or more heart attacks.
  • An ischemic stroke can be categorized into two types, a complete ischemic stroke or a partial ischemic stroke depending on how blood circulation disorder is affected.
  • a complete ischemic stroke blood circulation in a portion of the brain is completely cut off, and a cerebral infarction occurs. Since a cerebral infarction makes the portion of the brain in which it occurs functionally irrecoverable, disorders due to the cerebral infarction are permanent.
  • a transient ischemic attack is transient and includes local neurological symptoms due to a transient reduction of the blood supply to the brain.
  • a TIA causes symptoms similar to a stroke, but differs from the stroke in that the TIA is only a temporary disease. In particular, a TIA may last for several minutes and then disappear.
  • a TIA is a warning signal that a patient might have a stroke later due to dysfunctional blood circulation in the brain.
  • a conventional method of measuring an amount or rate of blood flow can be categorized into a method using the Doppler effect and a method using electromagnetic induction. Further, the method using the Doppler effect is classified into a method using a laser and a method using ultrasonic waves.
  • a laser Doppler blood flowmeter When a laser Doppler blood flowmeter is used, the rate of blood that flows through blood vessels is measured by inserting a glass fiber into a blood vessel and irradiating a laser beam in the blood vessel. Then, the rate of blood is measured using a variation of wavelength of a reflected light.
  • an ultrasonic blood flowmeter is used, blood flow is measured using a variation of an ultrasonic wave that is externally applied to blood.
  • a fundamental principle of the ultrasonic blood flowmeter is the same as that of the laser Doppler blood flowmeter.
  • An electromagnetic blood flowmeter measures the amount or rate of blood flow by detecting an electromotive force (EMF) of blood generated after a magnetic field is applied to blood vessels.
  • EMF electromotive force
  • measurement results of blood flow using the aforementioned conventional blood flowmeters are not precise because signals are affected by a stimulus to a human body or tissues inside or outside the skin.
  • these blood flowmeters are bulky, they are quite difficult to use, install, or transport.
  • a device for measuring a blood flow of a living body having blood vessels that emit bio-photons and through which blood flows including a detector positioned adjacent to a predetermined portion of the living body for measuring a bio-photon emission from the living body and a processor for analyzing and displaying the blood flow of the living body based on a value of the bio-photon emission.
  • the device may further include a shutter for controlling an amount of light incident on the detector.
  • the detector may operate in a darkroom.
  • the detector may be a photomultiplier or an optical receiver.
  • the device may further include a power supply for supplying power to the detector, a conveyor operable to move the detector three-dimensionally, and a preamplifier for converting the bio-photon emission detected by the detector into an electric signal and amplifying the electric signal.
  • the conveyor may include a stand, a support fixed on the stand, and a convey arm attached to the support operable to three-dimensionally control the movement of the detector.
  • the processor may include a display unit.
  • the device may further include a communication device for transmitting results of the analysis of the bio-photon emission.
  • a method of measuring a blood flow of a living body having blood vessels that emit bio-photons and through which blood flows including measuring a bio-photon emission using a detector, converting the bio-photon emission into an electric signal and amplifying the electric signal, calculating an amount of bio-photon emission measure per unit of time I D based on the amplified electric signal, comparing the amount of bio-photon emission per unit time I D with a preset value, and displaying a result of the comparison.
  • Comparing the amount of bio-photon emission per unit time I D with the preset value may be performed using the following inequality: wherein I ref is an average of amounts of bio-photon emissions measured on the living body for several previous days and I th is the preset value.
  • the method may further include issuing a warning signal to the user if is greater than or equal to the preset value I th .
  • Measuring the bio-photon emission may include positioning the detector adjacent to a predetermined portion of the living body, opening a shutter on the detector, and receiving the bio-photon emission by the detector.
  • Measuring the bio-photon emission may be performed in a darkroom.
  • the method may further include transmitting the result of the comparison using a communication device.
  • the present invention thus provides a device for and method of measuring blood flow using bio-photon emission that are economical and relatively simple, that may provide real time measurements to a patient being examined, and that may be connected to various communication devices to enable remote treatment and accumulation of information.
  • FIG. 1 illustrates a device for measuring blood flow using bio-photon emission according to an embodiment of the present invention.
  • a blood flow measurement device 100 includes a power supply 102, a detector 120, which may be a photomultiplier (PMT) or an optical receiver, a preamplifier 106, a processor 108, such as a computer/counting board, which may include a display, and a conveyor including a convey arm 122, a support 124, and a stand 126.
  • the power supply 102 supplies power to the blood flow measurement device 100.
  • the PMT 120 measures a bio-photon emission generated from an object 110.
  • the preamplifier 106 converts the measured bio-photon emission into an electric signal and amplifies the electric signal.
  • the processor 108 calculates the bio-photon emission using the amplified electric signal from the preamplifier 106.
  • the convey arm 122 moves the detector 120, and the support 124 supports the convey arm 122.
  • a shutter 121 is attached to the detector 120 to control an amount of light that is incident on the detector 120.
  • the detector 120 is three-dimensionally movable.
  • the detector 120 may be positioned adjacent to the object 110, i.e., a living body such as a human body.
  • adjacent may mean in contact with or in close proximity.
  • the shutter 121 attached to the detector 120 which has been previously turned on, is opened.
  • the shutter 121 remains closed until measurement begins because the detector 120 is susceptible to damage caused by exposure to light.
  • the detector 120 is able to measure the bio-photon emission, which is much dimmer than starlight. It is impossible to measure the bio-photon emission using a typical method of measuring light. The bio-photon emission may be measured in a darkroom.
  • the present invention is based on an assumption that the bio-photon emission varies with a state of the human body.
  • a photomultiplier PMT
  • the PMT since the PMT, which typically measures a bio-photon emission of a solid, amplifies one photon by a factor of a million to allow the bio-photon emission to be measured, the PMT should be manufactured to measure ultrafaint light.
  • the PMT is able to measure an amount of light radiated by a single bio-photon and thus, it can be referred to as a single photon counting.
  • the bio-photon emission measured by the detector 120 is displayed by the processor 108 through the preamplifier 106 so that a user is informed of a measurement result in real time.
  • the preamplifier 106 converts the bio-photon emission measured by the detector 120 into an electric signal, or a voltage, amplifies the electric signal, and outputs the amplified electric signal to the processor 108.
  • measurement of the bio-photon emission may be performed for about thirty (30) seconds after a dark level is measured.
  • the device may further include a communication device 112.
  • the communication device 112 is capable of transmitting results of the analysis of the bio-photon emission, thereby enabling remote treatment and accumulation of information on the health states of individuals.
  • the bio-photon emission decreases. Accordingly, when the blood flow measurement device 100 is used, it is possible to measure the bio-photon emission generated from a living body and predict a state of blood flow based on the measured bio-photon emission, thereby facilitating diagnosis of a health state of the living body.
  • FIG. 2 is a flowchart illustrating a method of measuring blood flow using bio-photon emission, the method being performed in the device of FIG. 1.
  • a user positions the detector 120 adjacent to an object 110, i.e., a living body, by controlling the convey arm 122 and opens the shutter 121, thereby allowing the detector 120 to receive bio-photon emission.
  • the bio-photon emission received by the detector 120 is converted into en electric signal, which is amplified by the preamplifier 106, and then output to the processor 108.
  • an amount I D of bio-photon emission measured per unit of time is calculated by the processor 108 based on the amplified electric signal.
  • a presence of a disorder of the living body may be determined using the following inequality: wherein I ref is an average of the amounts of bio-photon emissions that have been measured from the living body for several days before the present measurement, and I th is a preset critical value. If I th is preset to 20, when the measured I D is greater than + 20% or less than - 20%, the calculated value, exceeds the critical value I th .
  • a display unit for example, a liquid crystal display (LCD).
  • a warning signal such as a beep
  • the evaluation may include a notice of a blood flow abnormality along with an analysis of the associated disorder.
  • the method may additionally include, in operation S70, transmitting results of the analysis of the bio-photon emission via the communication device 112.
  • the present invention provides information on blood flow by using bio-photon emission, which varies with a state of a human body, as a bio signal without having to apply any physical, chemical, or physiological stimulus to the human body.
  • the method and device of an embodiment of the present invention are economical and relatively simple.
  • the present invention enables real time measurement so that a patient being examined may be instantaneously informed of the results and promptly take necessary measures based on the measurement results.
  • the device of the present invention can be directly connected to various communication devices, thereby enabling remote treatment and accumulation of information on the health states of individuals.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Mechanical Engineering (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Photometry And Measurement Of Optical Pulse Characteristics (AREA)
EP05250091A 2004-01-12 2005-01-11 Vorrichtung und Methode zur Messung des Blutflusses mittels Biophotonenemission Active EP1552783B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020040002031A KR100634499B1 (ko) 2004-01-12 2004-01-12 생체광자 측정을 통한 혈류 측정 장치 및 방법
KR2004002031 2004-01-12

Publications (2)

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EP1552783A1 true EP1552783A1 (de) 2005-07-13
EP1552783B1 EP1552783B1 (de) 2012-03-14

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US (2) US7270637B2 (de)
EP (1) EP1552783B1 (de)
JP (1) JP4224030B2 (de)
KR (1) KR100634499B1 (de)
CN (1) CN1316939C (de)

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JP5071767B2 (ja) * 2006-12-08 2012-11-14 学校法人日本大学 生体組織血流量測定装置
KR100869782B1 (ko) 2007-03-16 2008-11-21 전남대학교산학협력단 생체광학 영상장치
KR100982000B1 (ko) * 2008-03-28 2010-09-13 주식회사 씨알테크놀러지 광자계수형 디지털 검출기를 이용한 골밀도 측정 장치 및그 방법
US9271658B2 (en) 2011-01-10 2016-03-01 East Carolina University Methods, systems and computer program products for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling
US9226673B2 (en) 2011-01-10 2016-01-05 East Carolina University Methods, systems and computer program products for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling
CN107257655B (zh) 2014-10-14 2020-06-16 东卡罗莱娜大学 用于利用从多谱段血液流动和灌注成像获取的信号确定血液动力学状态参数的方法、系统和计算机程序产品
WO2016061052A1 (en) 2014-10-14 2016-04-21 East Carolina University Methods, systems and computer program products for visualizing anatomical structures and blood flow and perfusion physiology using imaging techniques
US11553844B2 (en) 2014-10-14 2023-01-17 East Carolina University Methods, systems and computer program products for calculating MetaKG signals for regions having multiple sets of optical characteristics
US10058256B2 (en) 2015-03-20 2018-08-28 East Carolina University Multi-spectral laser imaging (MSLI) methods and systems for blood flow and perfusion imaging and quantification
US10390718B2 (en) 2015-03-20 2019-08-27 East Carolina University Multi-spectral physiologic visualization (MSPV) using laser imaging methods and systems for blood flow and perfusion imaging and quantification in an endoscopic design
KR102644384B1 (ko) * 2023-09-19 2024-03-06 주식회사 휴원스 전기자극을 이용한 혈관 관리장치

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EP0984268A2 (de) 1998-09-03 2000-03-08 Beiersdorf Aktiengesellschaft Verfahren zur Erfassung ultraschwacher Photonenemission und dessen Verwendung
EP1126271A1 (de) * 2000-02-14 2001-08-22 Fritz-Albert Dr.rer.nat.habil. Visiting Professor Popp (mult.) Verfahren und Vorrichtung zur Bestimmung der Malignität von Tumorgewebe und zur Auswahl von Substanzen, die das Gewebe günstig beeinflussen

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Also Published As

Publication number Publication date
US7981044B2 (en) 2011-07-19
US20050154316A1 (en) 2005-07-14
CN1644159A (zh) 2005-07-27
KR20050073912A (ko) 2005-07-18
JP4224030B2 (ja) 2009-02-12
US20070299348A1 (en) 2007-12-27
JP2005199069A (ja) 2005-07-28
CN1316939C (zh) 2007-05-23
KR100634499B1 (ko) 2006-10-13
EP1552783B1 (de) 2012-03-14
US7270637B2 (en) 2007-09-18

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